MCID: DYS014
MIFTS: 55

Dyspepsia malady

Gastrointestinal diseases category

Summaries for Dyspepsia

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Dyspepsia, also known as indigestion, is related to duodenitis and irritable bowel syndrome. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Monoamine GPCRs and Gastric acid secretion. The compounds acetaminophen and lorglumide have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:63 Dyspepsia (from the Greek δυσ- dys- and πέψις pepsis \"digestion\"), also known as indigestion,... more...

Aliases & Classifications for Dyspepsia

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 60UMLS, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dyspepsia 8 10
indigestion 8 33
dyspepsia, indigestion nos 8
indigestion nos 8


External Ids:

Disease Ontology8 DOID:2321
MeSH34 D004415
NCIt39 C26756
ICD1025 K30

Related Diseases for Dyspepsia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dyspepsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis30.9S100A8, GAST, ATP4A
2irritable bowel syndrome30.9HTR4, MLN, ATP4A, TRPV1, HTR3A, CCK
3duodenal ulcer30.7HRH2, GAST, S100A8
4gastroesophageal reflux disease30.6CCKAR, CCK, S100A8, GAST, MLN, ATP4A
5peptic ulcer30.6CCK, S100A8, GAST, ATP4A, OCM, OCM2
6gastroparesis30.6CCK, HTR3A, HTR4, GAST, MLNR, MLN
7gastritis30.5GHRL, GAST, S100A8
8gastric ulcer30.4S100A8, GAST, GHRL, TRPV1, HRH2
9gastroduodenitis30.1GAST
10duodenogastric reflux30.1MLN, GAST, CCK
11gallbladder disease30.1MLN, MLNR, CCK, CCKAR
12eating disorder30.0GHRL
13bile reflux30.0CCK, ATP4A
14pancreatitis30.0CCK, CCKAR
15diarrhea30.0HTR3A, GAST, MLN, ATP4A
16esophagitis30.0S100A8, GAST, ATP4A, TRPV1, HRH2
17stomach cancer29.9CCK, S100A8, GAST, HRH2
18diabetic autonomic neuropathy29.8MLNR
19autonomic neuropathy29.8MLN, GAST, CCK
20constipation29.8CCK, HTR3A, HTR4, MLN
21diabetes mellitus29.8GHRL, MLN, GNB3, CCK, CCKAR
22obesity29.8CCKAR, CCK, GNB3, MLN, GHRL, TRPV1
23neuropathy29.8TRPV1
24eosinophilia10.2
25sleep disorder10.2
26migraine10.1
27bacterial gastritis10.1
28syndromic diarrhea10.0
29functional diarrhea10.0
30osteoarthritis10.0
31alexithymia10.0
32neuronitis10.0
33duodenal disease10.0
34gastroenteritis10.0
35periodontitis10.0
36hyperparathyroidism10.0GAST
37acromegaly10.0CCK, GHRL
38postcholecystectomy syndrome10.0GAST
39cholecystitis10.0CCK
40gastric outlet obstruction10.0GAST, MLN, ATP4A
41ileus10.0MLNR, MLN, GHRL
42functional colonic disease10.0HTR4, MLNR
43zollinger-ellison syndrome10.0HRH2, GAST
44cholelithiasis10.0CCK
45pituitary adenoma10.0SSTR3, GHRL
46neuroma10.0TRPV1
47hypoglycemia10.0GAST, MLN, GHRL
48obsessive-compulsive disorder10.0HTR3A
49atrophic gastritis10.0S100A8, GAST, GHRL
50bulimia nervosa10.0GHRL, CCK

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to dyspepsia

Clinical Features for Dyspepsia

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Drugs & Therapeutics for Dyspepsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dyspepsia

Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Search CenterWatch for Dyspepsia

Genetic Tests for Dyspepsia

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Anatomical Context for Dyspepsia

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32MalaCards
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MalaCards organs/tissues related to Dyspepsia:

32
Testes, Kidney, Brain, Spleen, Tongue, Heart, Lung, Liver, Breast, T cells, Small intestine, Colon

Animal Models for Dyspepsia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Dyspepsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0GAST, ATP4A, GHRL, IL17F, HRH2, NOX1
2MP:00053769.4ADRA2C, CCKAR, CCK, HTR3A, HTR4, GAST

Publications for Dyspepsia

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Sources:
50PubMed
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Articles related to Dyspepsia:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
2
Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study. (24179567)
2013
3
Dyspepsia. (23990632)
2013
4
Helicobacter pylori infection in nigerians with dyspepsia. (23966744)
2013
5
Acute gastroenteritis and the risk of functional dyspepsia: a systematic review and meta-analysis. (23711623)
2013
6
Sleep disorders in functional dyspepsia and future therapy. (23657063)
2013
7
Duodenal epithelial transport in functional dyspepsia: Role of serotonin. (23755368)
2013
8
Dysfunctional endogenous pain modulation in patients with functional dyspepsia. (24351013)
2013
9
Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study. (23884830)
2013
10
Impact of coexisting irritable bowel syndrome and non-erosive reflux disease on postprandial abdominal fullness and sleep disorders in functional dyspepsia. (24189354)
2013
11
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
12
Relationship between symptoms and gastric emptying of solids in functional dyspepsia. (23206454)
2012
13
Dyspepsia in Iran: SEPAHAN Systematic Review No. 3. (22826763)
2012
14
Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia. (22243034)
2012
15
Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography. (22385472)
2012
16
Eradicating Helicobacter pylori in functional dyspepsia. (22537648)
2012
17
Relationship between vitamin B12, folate and homocysteine levels and H. pylori infection in patients with functional dyspepsia: a cross-section study. (22546014)
2012
18
Presence of Helicobacter pylori in subgingival plaque of periodontitis patients with and without dyspepsia, detected by polymerase chain reaction and culture. (23162336)
2012
19
Irritable bowel syndrome, gastro-oesophageal reflux disease and dyspepsia: overlap analysis using loglinear models. (22560820)
2012
20
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. (22343090)
2012
21
Asian consensus report on functional dyspepsia. (22142407)
2012
22
Proton pump inhibitor versus prokinetic therapy in patients with functional dyspepsia: is therapeutic response predicted by Rome III subgroups? (20957498)
2011
23
Stool antigen test in diagnosis of Helicobacter pylori in older adults with dyspepsia. (22136548)
2011
24
Lithobezoar--an unusual cause of dyspepsia. (22693288)
2011
25
Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. (21245834)
2011
26
Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia. (21417958)
2011
27
The Prevalence of Occult Celiac Disease among Patients with Functional Dyspepsia: A Study from the Western Region of Iran. (21151702)
2010
28
Functional dyspepsia: time to change clinical trial design? (21131922)
2010
29
Effect of domperidone therapy on nocturnal dyspeptic symptoms of functional dyspepsia patients. (20128031)
2010
30
Implications of eosinophilia in the normal duodenal biopsy - an association with allergy and functional dyspepsia. (20222916)
2010
31
Dyspepsia, peptic ulcer, and H. pylori: a remembrance of things past. (20203639)
2010
32
Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. (20003077)
2010
33
Postinfectious functional dyspepsia and postinfectious irritable bowel syndrome: different symptoms but similar risk factors. (20346343)
2010
34
Genetic Polymorphisms of Molecules Associated with Innate Immune Responses, TRL2 and MBL2 Genes in Japanese Subjects with Functional Dyspepsia. (21103030)
2010
35
Counselling by primary care physicians may help patients with heartburn-predominant uninvestigated dyspepsia. (20352148)
2010
36
The study on the role of inflammatory cells and mediators in post-infectious functional dyspepsia. (20163288)
2010
37
The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. (20102604)
2010
38
Characterization of gastric volume responses and liquid emptying in functional dyspepsia and health by MRI or barostat and simultaneous C-acetate breath test. (19368659)
2009
39
Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia. (19494492)
2009
40
Functional dyspepsia and irritable bowel syndrome in patients with achalasia and its association with non-cardiac chest pain and a decreased health-related quality of life. (19263270)
2009
41
Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study. (19342860)
2009
42
Early history of dyspepsia and peptic ulcer in the United States. (19956114)
2009
43
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
44
Genetic polymorphisms of cyclooxygenase-1 (COX-1) are associated with functional dyspepsia in Japanese women. (18582172)
2008
45
Role of cholecystokinin and central serotonergic receptors in functional dyspepsia. (16552797)
2006
46
Distribution of vacA alleles and cagA status of Helicobacter pylori in peptic ulcer disease and non-ulcer dyspepsia. (15606640)
2004
47
Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia. (12269975)
2002
48
Cost-effectiveness of noninvasive testing and treatment strategies for H. pylori infection in children with dyspepsia. (9576448)
1998
49
Physiological effect of cholecystokinin on gastric emptying of liquid in functional dyspepsia. (7485011)
1995
50
Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gallbladder disease and postcholecystectomy. (3557185)
1987

Genetic Variations for Dyspepsia

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Expression for genes affiliated with Dyspepsia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 29KEGG
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Compounds for genes affiliated with Dyspepsia

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Dyspepsia according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1acetaminophen44 2 49 11 2414.8HRH2, GHRL
2lorglumide44 2811.7CCKAR, GAST, CCK
3l3652604410.7CCKAR, CCK, GAST
4ym0224410.7CCKAR, GAST, CCK
5dexloxiglumide44 2811.7MLN, HTR3A, CCKAR, CCK
6benzodiazepines4410.7HRH2, HTR3A, CCK, CCKAR
7ranitidine44 28 11 2413.7HRH2, MLN, CCK
8devazepide44 28 5912.7CCKAR, CCK, GAST
9caerulein4410.6MLN, CCK, CCKAR
10prucalopride44 2811.6HTR3A, HTR4, MLN
11pirenzepine44 28 1112.6HRH2, GHRL, GAST, CCK
12tegaserod44 28 1112.6MLN, HTR3A, CCK, HTR4
13bismuth44 2411.6GAST, HRH2, CCKAR
14loxiglumide4410.6CCKAR, CCK, GAST
15lafutidine4410.6GAST, HRH2, MLN
16oxyntomodulin44 5911.6CCK, GAST, MLN, GHRL
17pepsinogen4410.6CCK, HRH2, GAST
18granisetron44 1111.6CCK, HTR3A, HTR4
19metoclopramide44 1111.6MLN, HTR3A, CCK, HRH2, HTR4
20amide4410.6CCK, GAST, TRPV1, GHRL, CCKAR
21erythromycin44 49 2 1113.6GHRL, MLNR, GAST, CCKAR, MLN
22yohimbine44 28 2 1113.5ADRA2C, GAST, HTR4, HTR3A
23tetrodotoxin44 59 2812.5TRPV1, HTR3A, MLN, CCK, HRH2, CCKAR
24bethanechol44 28 1112.5GAST, CCK, MLN
25ondansetron44 49 11 2413.5HTR4, CCKAR, CCK, HTR3A, GAST, MLN
26cisapride44 28 1112.5HRH2, MLN, MLNR, CCK, HTR4, HTR3A
27octreotide44 59 28 1113.5CCKAR, CCK, SSTR3, GAST, MLN, GHRL
28olanzapine49 44 28 11 2414.5HTR3A, GNB3, ADRA2C, GHRL
29famotidine44 2 11 2413.5MLN, GHRL, HRH2, GAST
30gaba4410.5GHRL, TRPV1, GAST, HTR3A, CCK, CCKAR
31amoxicillin44 49 1112.5HRH2, GAST, S100A8
32atropine44 28 1112.4HTR4, HRH2, GHRL, GAST, MLN, CCK
33omeprazole44 28 49 11 2414.4CCK, GAST, MLN, ATP4A, HRH2, S100A8
34pantoprazole44 49 11 2413.4ATP4A, GAST, HRH2
355-hydroxytryptamine4410.4CCK, HRH2, GAST, HTR4, HTR3A, MLN
36histamine44 28 2412.4HTR3A, CCK, S100A8, GAST, MLN, HRH2
37acetylcholine44 49 28 11 2414.4HRH2, HTR3A, GHRL, MLN, GAST, HTR4
38norepinephrine44 11 2412.4CCK, GNB3, GAST, HTR3A, GHRL, ADRA2C
39domperidone44 28 1112.4HRH2, MLN, GAST
40adenylate4410.3MLN, CCK, HTR3A, GAST, TRPV1, HRH2
41acth4410.3CCK, GHRL, MLN, GAST, HTR4
42lansoprazole49 44 11 2413.3GAST, HRH2, ATP4A
43dopamine44 28 11 2413.3MLN, CCKAR, ADRA2C, TRPV1, GHRL, MLNR
44intralipid4410.3CCKAR, GHRL, CCK
45cholesterol44 28 11 2413.3CCK, GHRL, CCKAR, MLN, HRH2, GNB3
46hydrogen44 2411.2HRH2, TRPV1, NOX1, GHRL, MLN, GAST
47clozapine44 28 49 1113.1ADRA2C, HTR3A, GHRL, GNB3
48tyrosine4410.0GHRL, OCM2, TRPV1, CCK, S100A8, GAST
49glutamate4410.0GAST, CCK, S100A8, TRPV1, OCM2, GHRL
50nitric oxide44 11 2411.7HRH2, S100A8, GNB3, MLN, GHRL, TRPV1

GO Terms for genes affiliated with Dyspepsia

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Sources:
16Gene Ontology
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Cellular components related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8S100A8, GNB3, HTR3A, HTR4, MLNR, ATP4A
2integral to plasma membraneGO:0058879.5ADRA2C, CCKAR, HTR3A, HTR4, MLNR, ATP4A

Biological processes related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of sensory perception of painGO:05193010.4ADRA2C, CCK
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.2HTR4, SSTR3, HRH2
3digestionGO:00758610.2MLNR, HTR3A, CCKAR
4serotonin receptor signaling pathwayGO:00721010.0HTR4, HTR3A
5G-protein coupled receptor signaling pathwayGO:00718610.0ADRA2C, GHRL, MLN, MLNR, GAST, HTR4

Molecular functions related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3MLN, GAST, CCK

Products for genes affiliated with Dyspepsia

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Sources for Dyspepsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet