MCID: DYS014
MIFTS: 54

Dyspepsia malady

Gastrointestinal diseases category
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Summaries for Dyspepsia

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MedlinePlus:33 Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Dyspepsia, also known as indigestion, is related to irritable bowel syndrome and gastroparesis. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Monoamine GPCRs. The compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Wikipedia:65 Dyspepsia (from the Greek ???- dys-, \"bad\" or \"difficult\", and ????? pepsis \"digestion\"), also... more...

Aliases & Classifications for Dyspepsia

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Dyspepsia, Aliases & Descriptions:

Name: Dyspepsia 8 10
Indigestion 8 33
 
Dyspepsia, Indigestion Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:2321
NCIt39 C26756
MeSH34 D004415
ICD1025 K30

Related Diseases for Dyspepsia

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Diseases related to Dyspepsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.1CCK, HTR3A, TRPV1
2gastroparesis30.9CCK, HTR3A, GHRL
3eating disorder30.8GHRL
4duodenal ulcer30.8CCK, HRH2
5gallbladder disease30.7CCKAR, CCK
6peptic ulcer disease30.5CCK, HRH2
7celiac disease30.4GHRL, CCK
8migraine30.4TRPV1, HTR3A
9gastroesophageal reflux disease30.3CCK, CCKAR, HRH2, TRPV1
10constipation30.3CCK, HTR3A
11pancreatitis30.3CCKAR, CCK
12anxiety disorder30.2HTR3A, CCK
13gastritis30.2TRPV1, HRH2, GHRL, CCK
14esophagitis30.2TRPV1, HRH2
15diabetes mellitus30.0GHRL, CCKAR, CCK
16obesity29.8CCK, CCKAR, GHRL, TRPV1
17gastric ulcer29.8GHRL, HRH2, TRPV1
18stomach cancer29.7HRH2, GHRL, CCKAR
19asthma29.5GHRL, HRH2, TRPV1
20duodenitis10.7
21blindness10.5
22h. pylori infection10.4
23double outlet right ventricle10.3CCK, GHRL
24pancreas disease10.3CCK, CCKAR
25morbid obesity10.3GHRL, CCK
26glucagonoma10.3CCK, GHRL
27eosinophilia10.3
28sleep disorder10.3
29prader-willi syndrome10.2GHRL, CCK
30acromegaly10.2CCK, GHRL
31neuroendocrine tumor10.2GHRL, CCK
32psychotic disorder10.2HTR3A, CCK
33gastroduodenitis10.2
34cholestasis10.2HTR3A, CCK
35bacterial gastritis10.2
36thyroid medullary carcinoma10.2CCK, CCKAR, GHRL
37panic disorder10.1CCK, CCKAR, HTR3A
38type 2 diabetes mellitus10.1CCK, CCKAR, GHRL
39bulimia nervosa10.1GHRL, HTR3A, CCK
40anorexia nervosa10.1GHRL, HTR3A, CCK
41carcinoid syndrome10.1GHRL, HTR3A, CCK
42epilepsy syndrome10.1GHRL, HTR3A, CCK
43gastric cancer10.1
44osteoarthritis10.1
45bile reflux10.1
46alexithymia10.1
47neuronitis10.1
48duodenogastric reflux10.1
49diarrhea10.1
50gastroenteritis10.1

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to dyspepsia

Symptoms for Dyspepsia

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Drugs & Therapeutics for Dyspepsia

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Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Genetic Tests for Dyspepsia

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Anatomical Context for Dyspepsia

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MalaCards organs/tissues related to Dyspepsia:

32
Testes, Kidney, Brain, Spleen, Tongue, Heart, Small intestine, Colon, Liver, Lung, Breast, T cells, Neutrophil

Animal Models for Dyspepsia or affiliated genes

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MGI Mouse Phenotypes related to Dyspepsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9GHRL, HTR3A, CCKAR, CCK
2MP:00053867.3ADRA2C, CCKAR, HTR3A, GHRL, HRH2, TRPV1
3MP:00036317.1ADRA2C, CCK, CCKAR, HTR3A, HRH2, TRPV1
4MP:00053767.0TRPV1, ADRA2C, CCK, CCKAR, HTR3A, GHRL

Publications for Dyspepsia

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Articles related to Dyspepsia:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Treatment of functional dyspepsia and gastroparesis. (25169218)
2014
2
Impact of Microscopic Duodenitis on Symptomatic Response to Helicobacter pylori Eradication in Functional Dyspepsia. (25102980)
2014
3
Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats. (23142231)
2013
4
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
5
Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis. (24330675)
2013
6
Functional dyspepsia: the economic impact to patients. (23725230)
2013
7
The role of psychosocial factors and psychiatric disorders in functional dyspepsia. (23358396)
2013
8
Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study. (24179567)
2013
9
Decreased Basal and postprandial plasma serotonin levels in patients with functional dyspepsia. (23591288)
2013
10
Duodenal eosinophilia and Early Satiety in Functional Dyspepsia: Confirmation of a Positive Association in an Australian Cohort. (24304041)
2013
11
Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach. (23865590)
2013
12
Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria. (23399526)
2013
13
Clinically significant endoscopic findings in a multi-ethnic population with uninvestigated dyspepsia. (22688184)
2012
14
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
15
The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test. (22160229)
2012
16
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
17
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
18
Asian consensus report on functional dyspepsia: necessary and ready? (22436057)
2012
19
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
20
Prevalence of cagA, vacA, babA2 and iceA genes in H. pylori strains isolated from Colombian patients with functional dyspepsia. (22708344)
2012
21
Dyspepsia: Acotiamide can relieve symptoms of functional dyspepsia. (22249733)
2012
22
Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole--results from the STARS II study. (21848799)
2011
23
Randomised clinical trial: identification of responders to short-term treatment with esomeprazole for dyspepsia in primary care - a randomised, placebo-controlled study. (21083590)
2011
24
The role of Acid in functional dyspepsia. (21637272)
2011
25
Clinical and epidemiological perspectives of dyspepsia in a multiracial Malaysian population. (21443706)
2011
26
WITHDRAWN: Pharmacological interventions for non-ulcer dyspepsia. (21328253)
2011
27
Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia. (20535327)
2010
28
Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial. (20670451)
2010
29
Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria. (20823838)
2010
30
Identification of lactic acid bacteria isolated from the fecal samples of healthy humans and patients with dyspepsia, and determination of their ph, bile, and antibiotic tolerance properties. (20668388)
2010
31
Functional dyspepsia: a pragmatic approach. (21180236)
2010
32
Differences in gastrointestinal symptoms according to gender in Rome II positive IBS and dyspepsia in a Latin American population. (20179693)
2010
33
Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics. (19432972)
2009
34
Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. (19460766)
2009
35
The Role of RANTES Promoter Polymorphism in Functional Dyspepsia. (19794934)
2009
36
Functional dyspepsia: Validation and results of a novel survey instrument to evaluate patient knowledge and perceptions. (19398925)
2009
37
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
38
Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia. (18807132)
2008
39
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
40
Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. (15866221)
2005
41
Initial management strategies for dyspepsia. (16235292)
2005
42
Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia. (15043521)
2004
43
Comparison of endoscopic gastric mucosa features after administration of piroxicam to meloxicam and their correlation with dyspepsia symptoms in elderly patient with knee osteoarthritis. (15673949)
2004
44
Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia. (12269975)
2002
45
Analysis of vacA, cagA, and IS605 genotypes and those determined by PCR amplification of DNA between repetitive sequences of Helicobacter pylori strains isolated from patients with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. (10364612)
1999
46
Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in nonulcer dyspepsia. (8185214)
1994
47
Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia? A preliminary report of buspirone/prolactin responses. (2359983)
1990
48
The role of milk and lactose intolerance in Ethiopian patients with non-ulcer dyspepsia: a case control study. (2787744)
1989
49
Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gallbladder disease and postcholecystectomy. (3557185)
1987
50
Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease. (3545953)
1986

Variations for Dyspepsia

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Expression for genes affiliated with Dyspepsia

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Expression patterns in normal tissues for genes affiliated with Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

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Compounds for genes affiliated with Dyspepsia

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Compounds related to Dyspepsia according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4410.1CCK, CCKAR
2asperlicin4410.1CCK, CCKAR
3lorglumide44 2811.1CCKAR, CCK
4l3652604410.1CCKAR, CCK
5ym0224410.1CCK, CCKAR
6devazepide44 61 2812.1CCKAR, CCK
7caerulein4410.0CCKAR, CCK
8loxiglumide4410.0CCK, CCKAR
9decanoic acid44 28 1111.9CCK, GHRL
10octadecaneuropeptide449.9GHRL, CCK
11alosetron44 1110.9HTR3A, CCK
12aspartame44 24 1111.8CCK, TRPV1
13intralipid449.8CCKAR, GHRL, CCK
14granisetron50 44 1111.7CCK, HTR3A
15octreotide44 61 28 1112.7CCK, CCKAR, GHRL
16dexloxiglumide44 2810.7HTR3A, CCK, CCKAR
17benzodiazepine449.7HTR3A, CCKAR, CCK
18ondansetron50 44 24 1112.7CCK, CCKAR, HTR3A
19tegaserod44 28 1111.6HTR3A, CCK
20rimonabant44 28 1111.6CCK, GHRL
21bismuth44 2410.5CCKAR, HRH2
22quetiapine44 50 28 24 1113.5GHRL, HTR3A, ADRA2C
23thioperamide44 61 2811.5HRH2, HTR3A
24risperidone44 50 28 61 24 1114.5GHRL, HTR3A, ADRA2C
25cocaine44 1110.5GHRL, CCKAR, CCK
26olanzapine44 50 28 24 1113.5ADRA2C, HTR3A, GHRL
27morphine44 50 28 1112.5TRPV1, CCK, CCKAR
28clozapine44 28 50 1112.4ADRA2C, GHRL, HTR3A
29pepsinogen449.4CCK, HRH2
30carbohydrates449.4CCKAR, GHRL, CCK
31pramlintide44 1110.4GHRL, CCK
32omeprazole44 50 28 24 1113.3CCKAR, HRH2, CCK
33pirenzepine44 28 1111.3CCK, GHRL, HRH2
34amide449.3CCKAR, CCK, TRPV1, GHRL
35cisapride44 28 1111.2HTR3A, CCK, HRH2
36opiate449.2HRH2, GHRL, CCK
37metoclopramide44 50 1111.2CCK, HRH2, HTR3A
38acetaminophen44 2 50 24 1113.2HRH2, GHRL, CCK
39norepinephrine44 24 1111.1HTR3A, ADRA2C, GHRL, CCK
40atropine44 28 1111.0HRH2, GHRL, CCKAR, CCK
41benzodiazepines448.9HRH2, HTR3A, CCKAR, CCK
425-hydroxytryptamine448.8HTR3A, GHRL, CCK, HRH2
43gaba448.8CCKAR, TRPV1, GHRL, HTR3A, CCK
44histamine44 28 2410.8GHRL, HTR3A, HRH2, CCK
45acetylcholine44 50 28 24 1112.8HTR3A, CCK, HRH2, GHRL
46cholesterol44 28 24 1111.5HRH2, CCKAR, CCK, GHRL
47tetrodotoxin44 61 2810.4TRPV1, HRH2, HTR3A, CCKAR, CCK
48adenylate448.3HTR3A, GHRL, CCK, TRPV1, HRH2
49dopamine44 28 24 1111.3ADRA2C, CCK, HTR3A, GHRL, CCKAR, TRPV1
50forskolin44 50 1110.3HRH2, TRPV1, CCK, ADRA2C, GHRL

GO Terms for genes affiliated with Dyspepsia

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Cellular components related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.9CCK, HTR3A, GHRL
2plasma membraneGO:0058867.8TRPV1, HRH2, HTR3A, CCKAR, ADRA2C
3integral component of plasma membraneGO:0058877.7TRPV1, HRH2, HTR3A, CCKAR, ADRA2C

Biological processes related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:0072049.8GHRL, CCKAR
2digestionGO:0075869.7HTR3A, CCKAR
3regulation of sensory perception of painGO:0519309.7CCK, ADRA2C
4axonogenesisGO:0074099.6CCK, CCKAR
5neuron migrationGO:0017649.4CCKAR, CCK
6positive regulation of vasoconstrictionGO:0459079.2HRH2, ADRA2C

Products for genes affiliated with Dyspepsia

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