MCID: DYS014
MIFTS: 55

Dyspepsia malady

Gastrointestinal diseases category

Summaries for Dyspepsia

About this section
Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Dyspepsia, also known as indigestion, is related to duodenitis and irritable bowel syndrome. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Monoamine GPCRs and Gastric acid secretion. The compounds acetaminophen and lorglumide have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:63 Dyspepsia (from the Greek δυσ- dys- and πέψις pepsis \"digestion\"), also known as indigestion,... more...

Aliases & Classifications for Dyspepsia

About this section
Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 60UMLS, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dyspepsia 8 10
indigestion 8 33
dyspepsia, indigestion nos 8
indigestion nos 8


External Ids:

Disease Ontology8 DOID:2321
MeSH34 D004415
NCIt39 C26756
ICD1025 K30

Related Diseases for Dyspepsia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dyspepsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis30.9S100A8, GAST, ATP4A
2irritable bowel syndrome30.9HTR4, MLN, ATP4A, TRPV1, HTR3A, CCK
3duodenal ulcer30.7HRH2, GAST, S100A8
4gastroesophageal reflux disease30.6CCKAR, CCK, S100A8, GAST, MLN, ATP4A
5peptic ulcer30.6CCK, S100A8, GAST, ATP4A, OCM, OCM2
6gastroparesis30.6CCK, HTR3A, HTR4, GAST, MLNR, MLN
7gastritis30.5GHRL, GAST, S100A8
8gastric ulcer30.4S100A8, GAST, GHRL, TRPV1, HRH2
9gastroduodenitis30.1GAST
10duodenogastric reflux30.1MLN, GAST, CCK
11gallbladder disease30.1MLN, MLNR, CCK, CCKAR
12eating disorder30.0GHRL
13bile reflux30.0CCK, ATP4A
14pancreatitis30.0CCK, CCKAR
15diarrhea30.0HTR3A, GAST, MLN, ATP4A
16esophagitis30.0S100A8, GAST, ATP4A, TRPV1, HRH2
17stomach cancer29.9CCK, S100A8, GAST, HRH2
18diabetic autonomic neuropathy29.8MLNR
19autonomic neuropathy29.8MLN, GAST, CCK
20constipation29.8CCK, HTR3A, HTR4, MLN
21diabetes mellitus29.8GHRL, MLN, GNB3, CCK, CCKAR
22obesity29.8CCKAR, CCK, GNB3, MLN, GHRL, TRPV1
23neuropathy29.8TRPV1
24eosinophilia10.2
25sleep disorder10.2
26migraine10.1
27bacterial gastritis10.1
28syndromic diarrhea10.0
29functional diarrhea10.0
30osteoarthritis10.0
31alexithymia10.0
32neuronitis10.0
33duodenal disease10.0
34gastroenteritis10.0
35periodontitis10.0
36hyperparathyroidism10.0GAST
37acromegaly10.0CCK, GHRL
38postcholecystectomy syndrome10.0GAST
39cholecystitis10.0CCK
40gastric outlet obstruction10.0GAST, MLN, ATP4A
41ileus10.0MLNR, MLN, GHRL
42functional colonic disease10.0HTR4, MLNR
43zollinger-ellison syndrome10.0HRH2, GAST
44cholelithiasis10.0CCK
45pituitary adenoma10.0SSTR3, GHRL
46neuroma10.0TRPV1
47hypoglycemia10.0GAST, MLN, GHRL
48obsessive-compulsive disorder10.0HTR3A
49atrophic gastritis10.0S100A8, GAST, GHRL
50bulimia nervosa10.0GHRL, CCK

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to dyspepsia

Clinical Features for Dyspepsia

About this section

Drugs & Therapeutics for Dyspepsia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Dyspepsia

Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Search CenterWatch for Dyspepsia

Genetic Tests for Dyspepsia

About this section

Anatomical Context for Dyspepsia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Dyspepsia:

32
Testes, Kidney, Brain, Spleen, Tongue, Heart, Colon, Small intestine, Lung, Breast, T cells, Liver

Animal Models for Dyspepsia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Dyspepsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0GAST, ATP4A, GHRL, IL17F, HRH2, NOX1
2MP:00053769.4ADRA2C, CCKAR, CCK, HTR3A, HTR4, GAST

Publications for Dyspepsia

About this section
Sources:
50PubMed
See all sources

Articles related to Dyspepsia:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Functional dyspepsia: the economic impact to patients. (23725230)
2013
2
The role of psychosocial factors and psychiatric disorders in functional dyspepsia. (23358396)
2013
3
Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria. (23399526)
2013
4
A Study on the Efficacy of Proton Pump Inhibitors in Helicobacter pylori-Negative Primary Care Patients with Dyspepsia in Japan. (23423422)
2013
5
Initial management of dyspepsia in primary care: an evidence-based approach. (23998837)
2013
6
Comparison of gastric relaxation and sensory functions between functional dyspepsia and healthy subjects using novel drinking-ultrasonography test. (23343967)
2013
7
Helicobacter pylori infection in functional dyspepsia. (23358394)
2013
8
Clinical classification of subgroups according to the Rome III criteria cannot be used to distinguish the associated respective pathophysiology in Japanese patients with functional dyspepsia. (23774536)
2013
9
Functional dyspepsia: Glimmers of hope for functional dyspepsia. (23463176)
2013
10
The Effects of Banha-sasim-tang on Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial. (23861702)
2013
11
Efficacy of Helicobacter pylori Eradication Therapy on Functional Dyspepsia: A Meta-Analysis of Randomized Controlled Studies With 12-Month Follow-up. (24002127)
2013
12
Clinically significant endoscopic findings in a multi-ethnic population with uninvestigated dyspepsia. (22688184)
2012
13
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
14
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
15
Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega-Study (JMMS). (22004457)
2012
16
Association between mental distress, gastrointestinal symptoms, and health-care utilization in functional dyspepsia: a prospective 7-year follow-up study. (22229887)
2012
17
An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. (21747893)
2012
18
Darwinian dyspepsia: an extraordinary scientist, an ordinary illness, great dignity. (22306938)
2012
19
Dyspepsia and disease burden among patients with atrial fibrillation. (22337216)
2012
20
Etiopathogenesis of functional dyspepsia. (23155800)
2012
21
Assessment of gastric motor function in childhood functional dyspepsia and obesity. (22103293)
2012
22
Randomised clinical trial: sustained response to PPI treatment of symptoms resembling functional dyspepsia and irritable bowel syndrome in patients suffering from an overlap with erosive gastro-oesophageal reflux disease. (22486552)
2012
23
Asian consensus report on functional dyspepsia. (22523724)
2012
24
Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. (21684280)
2011
25
Application of sphygmography to detection of dyspepsia and the rhinitis. (21476205)
2011
26
Should we still subcategorize helicobacter pylori-associated dyspepsia as functional disease? (22148105)
2011
27
A placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsia. (21883698)
2011
28
Overlap syndrome of functional dyspepsia and irritable bowel syndrome - are both diseases mutually exclusive? (22148104)
2011
29
Current understanding of pathogenesis of functional dyspepsia. (21443711)
2011
30
Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach. (21630282)
2011
31
Long-term tegaserod treatment for dysmotility-like functional dyspepsia: results of two identical 1-year cohort studies. (19957035)
2010
32
Dyspepsia and irritable bowel syndrome: mutually exclusive conditions? (20636622)
2010
33
Development of a novel combination tablet containing trimebutine maleate and mosapride citrate for the treatment of functional dyspepsia. (20826201)
2010
34
The effect of a meal and water loading on heart rate variability in children with functional dyspepsia. (19882248)
2010
35
An unusual cause of dyspepsia: oesophageal cavernous haemangioma. (20360030)
2010
36
Is there any association between disturbed gastrointestinal visceromotor and sensory function and impaired quality of life in functional dyspepsia? (19814775)
2010
37
Duodenal implications in the pathophysiology of functional dyspepsia. (20680163)
2010
38
Prevalence of functional dyspepsia in an outpatient clinic with primary care physicians in Japan. (19997854)
2010
39
Functional dyspepsia: Validation and results of a novel survey instrument to evaluate patient knowledge and perceptions. (19398925)
2009
40
Intestinal immune activation in presumed post-infectious functional dyspepsia. (19460107)
2009
41
Uninvestigated dyspepsia and its related factors in an Iranian community. (19668901)
2009
42
Managing dyspepsia. (19615304)
2009
43
A Genetic Variant of the CD14 C-159T in Patients with Functional Dyspepsia (FD) in Japanese Subjects. (18385826)
2008
44
Ultrasound examination shows disturbed proximal gastric function in symptomatic gallstone patients with dyspepsia and improvement after cholecystectomy--gallstones and gastric emptying. (16894510)
2006
45
Erythromycin in the short- and long-term control of dyspepsia symptoms in patients with gastroparesis. (15128069)
2004
46
Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey. (12679943)
2003
47
Altered hypothalamic cholinergic responses in patients with nonulcer dyspepsia: a study of pyridostigmine-stimulated growth hormone release. (12190157)
2002
48
A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia--are central serotoninergic responses enhanced? (11564001)
2001
49
Serological response to Helicobacter pylori recombinant antigens in Chilean infected patients with duodenal ulcer, non-ulcer dyspepsia and gastric cancer. (10660136)
1999
50
Antritis and duodenitis in duodenal ulcer and non-ulcer dyspepsia. (4716539)
1973

Genetic Variations for Dyspepsia

About this section

Expression for genes affiliated with Dyspepsia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 29KEGG
See all sources

Compounds for genes affiliated with Dyspepsia

About this section
Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Dyspepsia according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1acetaminophen44 2 49 11 2414.8HRH2, GHRL
2lorglumide44 2811.7CCKAR, GAST, CCK
3l3652604410.7CCKAR, CCK, GAST
4ym0224410.7CCKAR, GAST, CCK
5dexloxiglumide44 2811.7MLN, HTR3A, CCKAR, CCK
6benzodiazepines4410.7HRH2, HTR3A, CCK, CCKAR
7ranitidine44 28 11 2413.7HRH2, MLN, CCK
8devazepide44 28 5912.7CCKAR, CCK, GAST
9caerulein4410.6MLN, CCK, CCKAR
10prucalopride44 2811.6HTR3A, HTR4, MLN
11pirenzepine44 28 1112.6HRH2, GHRL, GAST, CCK
12tegaserod44 28 1112.6MLN, HTR3A, CCK, HTR4
13bismuth44 2411.6GAST, HRH2, CCKAR
14loxiglumide4410.6CCKAR, CCK, GAST
15lafutidine4410.6GAST, HRH2, MLN
16oxyntomodulin44 5911.6CCK, GAST, MLN, GHRL
17pepsinogen4410.6CCK, HRH2, GAST
18granisetron44 1111.6CCK, HTR3A, HTR4
19metoclopramide44 1111.6MLN, HTR3A, CCK, HRH2, HTR4
20amide4410.6CCK, GAST, TRPV1, GHRL, CCKAR
21erythromycin44 49 2 1113.6GHRL, MLNR, GAST, CCKAR, MLN
22yohimbine44 28 2 1113.5ADRA2C, GAST, HTR4, HTR3A
23tetrodotoxin44 59 2812.5TRPV1, HTR3A, MLN, CCK, HRH2, CCKAR
24bethanechol44 28 1112.5GAST, CCK, MLN
25ondansetron44 49 11 2413.5HTR4, CCKAR, CCK, HTR3A, GAST, MLN
26cisapride44 28 1112.5HRH2, MLN, MLNR, CCK, HTR4, HTR3A
27octreotide44 59 28 1113.5CCKAR, CCK, SSTR3, GAST, MLN, GHRL
28olanzapine49 44 28 11 2414.5HTR3A, GNB3, ADRA2C, GHRL
29famotidine44 2 11 2413.5MLN, GHRL, HRH2, GAST
30gaba4410.5GHRL, TRPV1, GAST, HTR3A, CCK, CCKAR
31amoxicillin44 49 1112.5HRH2, GAST, S100A8
32atropine44 28 1112.4HTR4, HRH2, GHRL, GAST, MLN, CCK
33omeprazole44 28 49 11 2414.4CCK, GAST, MLN, ATP4A, HRH2, S100A8
34pantoprazole44 49 11 2413.4ATP4A, GAST, HRH2
355-hydroxytryptamine4410.4CCK, HRH2, GAST, HTR4, HTR3A, MLN
36histamine44 28 2412.4HTR3A, CCK, S100A8, GAST, MLN, HRH2
37acetylcholine44 49 28 11 2414.4HRH2, HTR3A, GHRL, MLN, GAST, HTR4
38norepinephrine44 11 2412.4CCK, GNB3, GAST, HTR3A, GHRL, ADRA2C
39domperidone44 28 1112.4HRH2, MLN, GAST
40adenylate4410.3MLN, CCK, HTR3A, GAST, TRPV1, HRH2
41acth4410.3CCK, GHRL, MLN, GAST, HTR4
42lansoprazole49 44 11 2413.3GAST, HRH2, ATP4A
43dopamine44 28 11 2413.3MLN, CCKAR, ADRA2C, TRPV1, GHRL, MLNR
44intralipid4410.3CCKAR, GHRL, CCK
45cholesterol44 28 11 2413.3CCK, GHRL, CCKAR, MLN, HRH2, GNB3
46hydrogen44 2411.2HRH2, TRPV1, NOX1, GHRL, MLN, GAST
47clozapine44 28 49 1113.1ADRA2C, HTR3A, GHRL, GNB3
48tyrosine4410.0GHRL, OCM2, TRPV1, CCK, S100A8, GAST
49glutamate4410.0GAST, CCK, S100A8, TRPV1, OCM2, GHRL
50nitric oxide44 11 2411.7HRH2, S100A8, GNB3, MLN, GHRL, TRPV1

GO Terms for genes affiliated with Dyspepsia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8S100A8, GNB3, HTR3A, HTR4, MLNR, ATP4A
2integral to plasma membraneGO:0058879.5ADRA2C, CCKAR, HTR3A, HTR4, MLNR, ATP4A

Biological processes related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of sensory perception of painGO:05193010.4ADRA2C, CCK
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.2HTR4, SSTR3, HRH2
3digestionGO:00758610.2MLNR, HTR3A, CCKAR
4serotonin receptor signaling pathwayGO:00721010.0HTR4, HTR3A
5G-protein coupled receptor signaling pathwayGO:00718610.0ADRA2C, GHRL, MLN, MLNR, GAST, HTR4

Molecular functions related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3MLN, GAST, CCK

Products for genes affiliated with Dyspepsia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dyspepsia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet