MCID: DYS014
MIFTS: 50

Dyspepsia malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Dyspepsia

Aliases & Descriptions for Dyspepsia:

Name: Dyspepsia 12 42 14
Indigestion 12 41 14
Dyspepsia, Indigestion Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2321
ICD10 33 K30 R10.13
MeSH 42 D004415
NCIt 47 C26756
UMLS 69 C0013395

Summaries for Dyspepsia

MedlinePlus : 41 nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Dyspepsia, also known as indigestion, is related to schizophrenia and opisthorchiasis. An important gene associated with Dyspepsia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Dopamine and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 71 Indigestion, also known as dyspepsia, is a condition of impaired digestion. Symptoms may include upper... more...

Related Diseases for Dyspepsia

Diseases related to Dyspepsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 schizophrenia 28.5 CCK CCKAR GNB3 HRH2 HTR1A HTR3A
2 opisthorchiasis 10.8
3 duodenitis 10.3
4 irritable bowel syndrome 10.3
5 ornithosis 10.2 CCK HTR3A SLC6A4
6 ischemic neuropathy 10.2 CCK GHRL HTR3A
7 cholesteatoma 10.2 CCK GHRL SLC6A4
8 nutritional optic neuropathy 10.2 GHRL SST
9 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.2 CCK GHRL SLC6A4
10 abnormal pupillary function 10.1 HTR1A HTR3A
11 gastroesophageal reflux 10.1
12 chagas disease 10.1 CCK GHRL HTR3A SLC6A4
13 simultanagnosia 10.1 CCK PTGS2 TRPV1
14 anodontia 10.1 HTR1A HTR3A SLC6A4
15 renpenning syndrome 10.1 HTR1A HTR3A SLC6A4
16 gemistocytic astrocytoma 10.1 CCK HRH2 SST
17 cervical carcinosarcoma 10.1 CCK PTGS2 TRPV1
18 gastroparesis 10.1
19 postencephalitic parkinson disease 10.1 HTR1A HTR3A SLC6A4
20 borderline leprosy 10.1 CCK CCKAR SST
21 deafness, autosomal recessive 20 10.1 CCK HTR3A SLC6A4 TRPV1
22 autism spectrum disorder 10.1 CCK GHRL SLC6A4 TRPV1
23 cushing's syndrome 10.1 CCK PTGS2
24 small intestinal l-cell glucagon-like peptide producing tumor 10.1 HRH2 PTGS1 PTGS2
25 primary non-gestational choriocarcinoma of ovary 10.1 CXCL8 PTGS2
26 dry eye syndrome 10.1 HTR1A SLC6A4
27 duodenal ulcer 10.1
28 cervicitis 10.0 CCK PTGS1 PTGS2
29 peroneal neuropathy 10.0 GHRL SST TRPV1
30 tinea pedis 10.0 CYP2C19 HTR1A SLC6A4
31 pagon stephan syndrome 10.0 PTGS1 PTGS2
32 sweat gland cancer 10.0 CCK HTR3A SLC6A4 SST
33 gastritis 10.0
34 body dysmorphic disorder 10.0 GHRL SST TRPV1
35 peptic ulcer disease 10.0
36 angioedema 10.0 HRH2 PTGS1 PTGS2
37 hepatitis d 10.0 CCK HTR1A HTR3A SLC6A4
38 lacrimal apparatus disease 10.0 CXCL8 CYP2C19 HRH2
39 retinoblastoma 10.0 HTR1A HTR3A SLC6A4
40 uterine ligament clear cell adenocarcinoma 10.0 CXCL8 GHRL TRPV1
41 ovarian mucinous neoplasm 10.0 CYP2C19 HRH2 PTGS2 TRPV1
42 mucositis 10.0
43 personality disorder 10.0 CCK HTR1A SLC6A4 TRPV1
44 neovascular glaucoma 10.0 CXCL8 PTGS2 TRPV1
45 myocardial stunning 10.0 CCK SST
46 chronic conjunctivitis 10.0 HTR1A HTR3A SLC6A4
47 hepatitis b reinfection following liver transplantation 9.9 HTR1A HTR3A SLC6A4 SST
48 lichen disease 9.9 CXCL8 HTR1A SLC6A4
49 h. pylori infection 9.9
50 preeclampsia/eclampsia 5 9.9 CCK GHRL HTR1A HTR3A SLC6A4

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to Dyspepsia

Symptoms & Phenotypes for Dyspepsia

GenomeRNAi Phenotypes related to Dyspepsia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.23 HRH2 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.23 HRH2 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Dyspepsia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 SST TRPV1 CCK CCKAR GHRL HRH2
2 endocrine/exocrine gland MP:0005379 9.76 HTR3A PTGS1 PTGS2 SLC6A4 CCK CCKAR
3 digestive/alimentary MP:0005381 9.73 CCKAR GHRL HRH2 PTGS1 PTGS2 SST
4 homeostasis/metabolism MP:0005376 9.7 CCK CCKAR GHRL HRH2 HTR1A HTR3A
5 nervous system MP:0003631 9.36 CCK CCKAR GNB3 HRH2 HTR1A HTR3A

Drugs & Therapeutics for Dyspepsia

Drugs for Dyspepsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 326)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Pantoprazole Approved Phase 4,Phase 2,Phase 3 102625-70-7 4679
5
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
6
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
7
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
8
Histamine Approved, Investigational Phase 4,Phase 2,Phase 3 75614-87-8, 51-45-6 774
9
Ranitidine Approved Phase 4,Phase 2,Phase 3 66357-59-3, 66357-35-5 3001055
10
Famotidine Approved Phase 4,Phase 3 76824-35-6 3325
11
Mianserin Approved Phase 4 24219-97-4 4184
12
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 1 22204-53-1 1302 156391
13
Amitriptyline Approved Phase 4,Phase 2,Phase 3 50-48-6 2160
14
Clarithromycin Approved Phase 4,Phase 3,Phase 2 81103-11-9 84029
15
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
16
Metronidazole Approved Phase 4,Phase 3 443-48-1 4173
17
Lubiprostone Approved, Investigational Phase 4 136790-76-6 656719
18
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
19
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 103577-45-3 3883
20
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 161796-78-7, 119141-88-7 4594 9579578
21
Cyclobenzaprine Approved Phase 4 303-53-7 2895
22
Aluminum hydroxide Approved Phase 4,Phase 3 21645-51-2
23
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
24
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
25
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
26
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
27
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
28
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
29
Rabeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 117976-89-3 5029
30
Tinidazole Approved, Investigational Phase 4,Phase 2,Phase 3 19387-91-8 5479
31
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
32
Furazolidone Approved, Vet_approved Phase 4 67-45-8 3435 5323714
33
Guaifenesin Approved, Vet_approved Phase 4,Phase 3 93-14-1 3516
34
Magnesium Hydroxide Approved Phase 4 1309-42-8
35
Potassium Citrate Approved, Vet_approved Phase 4
36
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
37 Trimebutine Approved Phase 4 39133-31-8
38
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
39
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
40 Parecoxib Approved Phase 4 198470-84-7
41
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 54575, 6560146 143
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
43
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
44
decanoic acid Experimental Phase 4 334-48-5 2969
45
Maleic acid Experimental Phase 4 110-16-7 444266
46
Bismuth Phase 4,Phase 2,Phase 3 7440-69-9 16682734 105143
47 Ranitidine bismuth citrate Phase 4,Phase 2,Phase 3
48
Dexlansoprazole Phase 4,Phase 3,Phase 1,Phase 2 138530-94-6, 103577-45-3 9578005
49
Histamine Phosphate Phase 4,Phase 2,Phase 3 51-74-1 65513
50
Proton pump inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 308)
id Name Status NCT ID Phase
1 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4
2 Mirtazapine Versus Placebo in Functional Dyspepsia Unknown status NCT01240096 Phase 4
3 The Efficacy of Pantoprazole Treatment in Patients With Functional Dyspepsia Unknown status NCT01608750 Phase 4
4 The Efficacy and Safety Study of Rikkunshito in Patients With Functional Dyspepsia Unknown status NCT02037776 Phase 4
5 Clinical Study to Evaluate the Efficacy and the Safety of Eradication Therapy for Helicobacter Pylori in Functional Dyspepsia Unknown status NCT00990405 Phase 4
6 Gastric Functions & Proton Pump Inhibitor( PPI) Study Unknown status NCT00951431 Phase 4
7 Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice Unknown status NCT00363701 Phase 4
8 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4
9 Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy Unknown status NCT02105090 Phase 4
10 Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit Unknown status NCT00844831 Phase 4
11 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4
12 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4
13 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4
14 Efficacy of Banhasasim-tang on Functional Dyspepsia Completed NCT00987805 Phase 4
15 Comparison of Pantoprazole and Ranitidine in Dyspepsia Completed NCT01737840 Phase 4
16 Compliance With Antidepressant Medication in Treatment of Functional Dyspepsia Completed NCT01851863 Phase 4
17 Lansoprazole Versus Mosapride for Functional Dyspepsia Completed NCT00663897 Phase 4
18 A Study to Demonstrate the Efficacy and Safety of Motilitone® Completed NCT01817465 Phase 4
19 The Efficacy and Safety of Qizhiweitong Granule on Patients With Functional Dyspepsia in a Multi-center Clinical Study Completed NCT02460601 Phase 4
20 A Comparison of Efficacy of Intravenous Esomeprazole and Ranitidine Treatment of Dyspeptic Pain Completed NCT02197143 Phase 4
21 High Dose PPI Triple Therapy Versus Sequential Therapy for Helicobacter Pylori Eradication Completed NCT01888237 Phase 4
22 Proton Pump Inhibitor Treatment Stop Completed NCT00120315 Phase 4
23 Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders Completed NCT02566876 Phase 4
24 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4
25 Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole Completed NCT01281501 Phase 4
26 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4
27 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4
28 Amtolmetin Gaucil in Knee Osteoarthritis Completed NCT02865161 Phase 4
29 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4
30 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4
31 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4
32 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4
33 Ulcer Prevention Study in Post Gastric Bypass Patients Completed NCT00557349 Phase 4
34 Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection Completed NCT02835560 Phase 4
35 Glucomannan for the Treatment of Abdominal Pain-related Functional Gastrointestinal Disorders in Childhood Completed NCT01495806 Phase 4
36 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4
37 Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients Completed NCT00650455 Phase 4
38 Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole Completed NCT00640809 Phase 4
39 Randomized, Double Blind, Multicenter Study of the Safety and Efficacy of Valdecoxib 40 mg Once Daily Compared With Diclofenac 75 mg Twice Daily in Acute Low Back Pain Completed NCT00649610 Phase 4
40 Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia Recruiting NCT02134405 Phase 4
41 BRAVO Study for Functional Dyspepsia Recruiting NCT01349413 Phase 4
42 Effect of Short-term Motilitone Therapy on Health-related Quality of Life in PD Patients With Gastrointestinal Symptoms Recruiting NCT02775591 Phase 4
43 Mast Cells in Acid-induced Intestinal Permeability Recruiting NCT02664051 Phase 4
44 Prucalopride Versus Placebo in Gastroparesis Recruiting NCT02510976 Phase 4
45 Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment Recruiting NCT02988089 Phase 4
46 Heweizhixie capsuleTherapy on Patients With Diarrhea Recruiting NCT02607176 Phase 4
47 Helicobacter Eradication Aspirin Trial Recruiting NCT01506986 Phase 4
48 Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Recruiting NCT02986685 Phase 4
49 Clinical Trial of Efficacy and Safety of Kolofort in Functional Dyspepsia Patients Not yet recruiting NCT03119766 Phase 4
50 Therapeutic Effect of Ursodeoxycholic Acid in Functional Dyspepsia Not yet recruiting NCT03004118 Phase 4

Search NIH Clinical Center for Dyspepsia

Cochrane evidence based reviews: dyspepsia

Genetic Tests for Dyspepsia

Anatomical Context for Dyspepsia

MalaCards organs/tissues related to Dyspepsia:

39
Testes, Kidney, Brain, Spleen, Heart, Tongue, Small Intestine

Publications for Dyspepsia

Articles related to Dyspepsia:

(show top 50) (show all 749)
id Title Authors Year
1
Editorial: Moving Away From Focussing on Gastric Pathophysiology in Functional Dyspepsia: New Insights and Therapeutic Implications. ( 28050031 )
2017
2
The Role of Duodenal Inflammation in Functional Dyspepsia. ( 27811629 )
2017
3
Pathophysiological Abnormalities in Functional Dyspepsia Subgroups According to the Rome III Criteria. ( 27958284 )
2017
4
Celiac disease prevalence is not increased in patients with functional dyspepsia. ( 28079237 )
2017
5
Minimal differences in prevalence and spectrum of organic disease at upper gastrointestinal endoscopy between selected secondary care patients with symptoms of gastro-oesophageal reflux or dyspepsia. ( 27973922 )
2017
6
Self-rated health and functional capacity in individuals reporting overlapping symptoms of gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome - a population based study. ( 28521729 )
2017
7
Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia. ( 28052285 )
2017
8
Dyspepsia and constipation in patients with schizophrenia spectrum disorders. ( 27564411 )
2016
9
Helicobacter pylori and Its Virulence Factors' Effect on Serum Oxidative DNA Damages in Adults With Dyspepsia. ( 28033692 )
2016
10
Effect of acupuncture and its influence on cerebral activity in functional dyspepsia patients: study protocol for a randomized controlled trial. ( 27039086 )
2016
11
Appetite-regulating gut peptides and functional dyspepsia. ( 27725457 )
2016
12
The Intragastric Pressure Measurement: A Novel Method to Assess Gastric Accommodation in Functional Dyspepsia Children. ( 27557427 )
2016
13
Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia. ( 27013784 )
2016
14
Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. ( 27444264 )
2016
15
A study of clinico-endoscopic profile of patient presenting with dyspepsia. ( 27727685 )
2016
16
Influence of CYP2C19 on Helicobacter pylori eradication in Brazilian patients with functional dyspepsia. ( 27706745 )
2016
17
Implementation and evaluation of early gastroscopy for patients with dyspepsia and warning signs in Primary Care. ( 28010892 )
2016
18
Dyspepsia and the microbiome: time to focus on the small intestine. ( 27489239 )
2016
19
Individualized Acupuncture for Symptom Relief in Functional Dyspepsia: A Randomized Controlled Trial. ( 27732083 )
2016
20
Upregulation of Vanilloid Receptor-1 in Functional Dyspepsia With or Without Helicobacter pylori Infection. ( 27175641 )
2016
21
Functional dyspepsia: new insights into pathogenesis and therapy. ( 27048251 )
2016
22
The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients. ( 27840636 )
2016
23
Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia: Results of a Multicenter Survey Study. ( 27069497 )
2016
24
Histopathological study of upper gastrointestinal endoscopic biopsy in patients with dysphagia and dyspepsia in south western coast of India. ( 27772904 )
2016
25
Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis. ( 27022230 )
2016
26
Nutritional habits in functional dyspepsia and its subgroups: a comparative study. ( 27124324 )
2016
27
Dietary fat intake and functional dyspepsia. ( 27195249 )
2016
28
Gastric Activity and Gut Peptides in Patients With Functional Dyspepsia: Postprandial Distress Syndrome Versus Epigastric Pain Syndrome. ( 27092429 )
2016
29
Gastric siderosis as a cause of dyspepsia. ( 27511759 )
2016
30
The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia. ( 27644564 )
2016
31
Development of a Symptom-Based Patient-Reported Outcome Instrument for Functional Dyspepsia: A Preliminary Conceptual Model and an Evaluation of the Adequacy of Existing Instruments. ( 27020447 )
2016
32
Association of Psychological Characteristics and Functional Dyspepsia Treatment Outcome: A Case-Control Study. ( 27547220 )
2016
33
Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups. ( 27160990 )
2016
34
Sleep disturbance due to heartburn and regurgitation is common in patients with functional dyspepsia. ( 27087946 )
2016
35
Evaluating community pharmacists` dyspepsia knowledge: A cross-sectional study in Tehran, Iran. ( 27594437 )
2016
36
The C825T Polymorphism of the G-Protein I^3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis. ( 27057160 )
2016
37
Pattern of psychotropic medications use in a cohort of patients with uninvestigated dyspepsia undergoing upper endoscopy: A retrospective study. ( 27858904 )
2016
38
Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection. ( 27448107 )
2016
39
Gastric microbiota in the functional dyspepsia patients treated with probiotic yogurt. ( 27752337 )
2016
40
Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study. ( 27503912 )
2016
41
Helicobacter pylori eradication effect on patients with functional dyspepsia symptoms. ( 27091036 )
2016
42
Factors associated with the occurrence ofA functional dyspepsia and insomnia inA shift-working nurses. ( 27061691 )
2016
43
Functional Dyspepsia: An Enigma in a Conundrum. ( 27437927 )
2016
44
Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis. ( 27028618 )
2016
45
Effect of Shuwei Decoction () on rats with functional dyspepsia. ( 27392478 )
2016
46
Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. ( 27478434 )
2016
47
Self-medication of irritable bowel syndrome and dyspepsia: How appropriate is it? ( 27162806 )
2016
48
Validation of the Leuven Postprandial Distress Scale, a questionnaire for symptom assessment in the functional dyspepsia/postprandial distress syndrome. ( 27518319 )
2016
49
Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia. ( 27457769 )
2016
50
Functional dyspepsia. ( 27540688 )
2016

Variations for Dyspepsia

Expression for Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for Dyspepsia

Pathways related to Dyspepsia according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CCK CCKAR CXCL8 GHRL GNB3 HRH2
2 12.24 GNB3 HTR1A PTGS1 PTGS2
3
Show member pathways
11.74 GNB3 HTR1A HTR3A
4
Show member pathways
11.7 CYP2C19 PTGS1 PTGS2
5 11.65 CXCL8 GNB3 HTR1A HTR3A SLC6A4 SST
6 11.25 CYP2C19 GNB3 PTGS1
7 11.22 CYP2C19 GNB3 HTR1A HTR3A PTGS1 PTGS2
8
Show member pathways
10.96 PTGS1 PTGS2
9 10.94 HTR1A HTR3A SLC6A4
10 10.89 PTGS1 PTGS2
11 10.86 PTGS1 PTGS2
12 10.61 CXCL8 PTGS1 PTGS2
13 10.58 PTGS1 PTGS2

GO Terms for Dyspepsia

Cellular components related to Dyspepsia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 CCK HTR3A SST TRPV1
2 neuron projection GO:0043005 9.26 GNB3 PTGS2 SLC6A4 TRPV1
3 organelle membrane GO:0031090 8.8 CYP2C19 PTGS1 PTGS2

Biological processes related to Dyspepsia according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.86 CXCL8 PTGS1 PTGS2 TRPV1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.74 CCKAR GHRL TRPV1
3 response to nutrient GO:0007584 9.65 CCKAR SLC6A4 SST
4 excitatory postsynaptic potential GO:0060079 9.63 GHRL HTR3A TRPV1
5 decidualization GO:0046697 9.58 GHRL PTGS2
6 regulation of blood pressure GO:0008217 9.58 GNB3 PTGS1 PTGS2
7 prostaglandin metabolic process GO:0006693 9.55 PTGS1 PTGS2
8 vasoconstriction GO:0042310 9.54 HTR1A SLC6A4
9 digestion GO:0007586 9.54 CCKAR PGC SST
10 prostaglandin biosynthetic process GO:0001516 9.52 PTGS1 PTGS2
11 cellular response to ATP GO:0071318 9.51 PTGS2 TRPV1
12 memory GO:0007613 9.5 HRH2 PTGS2 SLC6A4
13 G-protein coupled receptor signaling pathway GO:0007186 9.5 CCKAR CXCL8 GHRL GNB3 HRH2 HTR1A
14 cyclooxygenase pathway GO:0019371 9.49 PTGS1 PTGS2
15 serotonin receptor signaling pathway GO:0007210 9.43 HTR1A HTR3A
16 response to organonitrogen compound GO:0010243 9.33 PTGS2 SST TRPV1
17 regulation of hormone secretion GO:0046883 9.26 CCKAR HTR1A
18 negative regulation of synaptic transmission, dopaminergic GO:0032227 8.62 PTGS2 SLC6A4

Molecular functions related to Dyspepsia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.62 CCKAR GNB3 HRH2 HTR1A
2 heme binding GO:0020037 9.43 CYP2C19 PTGS1 PTGS2
3 hormone activity GO:0005179 9.33 CCK GHRL SST
4 serotonin binding GO:0051378 8.96 HTR1A HTR3A
5 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Dyspepsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....