MCID: DYS014
MIFTS: 54

Dyspepsia malady

Gastrointestinal diseases category
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Summaries for Dyspepsia

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Dyspepsia, also known as indigestion, is related to irritable bowel syndrome and duodenal ulcer. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Monoamine GPCRs. The compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Wikipedia:65 Dyspepsia (from the Greek ???- dys-, \"bad\" or \"difficult\", and ????? pepsis \"digestion\"), also... more...

Aliases & Classifications for Dyspepsia

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Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 58SNOMED-CT, 35MeSH, 62UMLS, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dyspepsia 8 10
indigestion 8 34
dyspepsia, indigestion nos 8
indigestion nos 8


External Ids:

Disease Ontology8 DOID:2321
MeSH35 D004415
NCIt40 C26756
ICD1025 K30

Related Diseases for Dyspepsia

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17GeneCards, 18GeneDecks
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Diseases related to Dyspepsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.0CCK, HTR3A, TRPV1
2duodenal ulcer30.7CCK, HRH2
3gastroparesis30.7CCK, GHRL, HTR3A
4gastroesophageal reflux disease30.6CCK, CCKAR, HRH2, TRPV1
5gastritis30.5CCK, GHRL, TRPV1, HRH2
6peptic ulcer disease30.4HRH2, CCK
7gallbladder disease30.3CCK, CCKAR
8eating disorder30.3GHRL
9migraine30.3HTR3A, TRPV1
10pancreatitis30.1CCKAR, CCK
11esophagitis30.1TRPV1, HRH2
12constipation30.0HTR3A, CCK
13anxiety disorder30.0HTR3A, CCK
14celiac disease29.9GHRL, CCK
15stomach cancer29.9CCKAR, GHRL, HRH2
16diabetes mellitus29.9GHRL, CCK, CCKAR
17obesity29.8CCK, CCKAR, GHRL, TRPV1
18gastric ulcer29.8HRH2, TRPV1, GHRL
19duodenitis10.7
20blindness10.5
21h. pylori infection10.3
22eosinophilia10.3
23sleep disorder10.2
24paine syndrome10.2
25gastroduodenitis10.2
26bacterial gastritis10.1
27alexithymia10.1
28neuronitis10.1
29duodenogastric reflux10.1
30osteoarthritis10.1
31bile reflux10.1
32diarrhea10.1
33gastroenteritis10.1
34periodontitis10.1
35bulimia nervosa10.1GHRL, CCK
36morbid obesity10.1CCK, GHRL
37pancreas disease10.1CCK, CCKAR
38glucagonoma10.1GHRL, CCK
39prader-willi syndrome10.1GHRL, CCK
40acromegaly10.1CCK, GHRL
41neuroendocrine tumor10.0CCK, GHRL
42psychotic disorder10.0CCK, HTR3A
43cholestasis10.0CCK, HTR3A
44thyroid medullary carcinoma10.0CCK, CCKAR, GHRL
45panic disorder10.0HTR3A, CCKAR, CCK
46type 2 diabetes mellitus10.0GHRL, CCKAR, CCK
47anorexia nervosa10.0GHRL, CCK, HTR3A
48carcinoid syndrome10.0CCK, GHRL, HTR3A
49epilepsy syndrome10.0HTR3A, GHRL, CCK
50pancreatic cancer10.0CCKAR, CCK

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to dyspepsia

Symptoms for Dyspepsia

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Drugs & Therapeutics for Dyspepsia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Genetic Tests for Dyspepsia

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Anatomical Context for Dyspepsia

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33MalaCards
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MalaCards organs/tissues related to Dyspepsia:

33
Testes, Kidney, Brain, Spleen, Tongue, Heart, T cells, Breast, Colon, Liver, Lung, Small intestine

Animal Models for Dyspepsia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dyspepsia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9CCK, CCKAR, HTR3A, GHRL
2MP:00053867.3GHRL, HTR3A, HRH2, CCKAR, TRPV1, ADRA2C
3MP:00036317.1HRH2, HTR3A, CCKAR, CCK, TRPV1, ADRA2C
4MP:00053767.0CCKAR, CCK, HTR3A, GHRL, HRH2, TRPV1

Publications for Dyspepsia

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Sources:
52PubMed
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Articles related to Dyspepsia:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats. (23142231)
2013
2
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
3
Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis. (24330675)
2013
4
Functional dyspepsia: the economic impact to patients. (23725230)
2013
5
The role of psychosocial factors and psychiatric disorders in functional dyspepsia. (23358396)
2013
6
Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study. (24179567)
2013
7
Decreased Basal and postprandial plasma serotonin levels in patients with functional dyspepsia. (23591288)
2013
8
Duodenal eosinophilia and Early Satiety in Functional Dyspepsia: Confirmation of a Positive Association in an Australian Cohort. (24304041)
2013
9
Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach. (23865590)
2013
10
Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria. (23399526)
2013
11
Clinically significant endoscopic findings in a multi-ethnic population with uninvestigated dyspepsia. (22688184)
2012
12
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
13
The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test. (22160229)
2012
14
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
15
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
16
Asian consensus report on functional dyspepsia: necessary and ready? (22436057)
2012
17
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
18
Prevalence of cagA, vacA, babA2 and iceA genes in H. pylori strains isolated from Colombian patients with functional dyspepsia. (22708344)
2012
19
Dyspepsia: Acotiamide can relieve symptoms of functional dyspepsia. (22249733)
2012
20
Randomised clinical trial: identification of responders to short-term treatment with esomeprazole for dyspepsia in primary care - a randomised, placebo-controlled study. (21083590)
2011
21
The role of Acid in functional dyspepsia. (21637272)
2011
22
Clinical and epidemiological perspectives of dyspepsia in a multiracial Malaysian population. (21443706)
2011
23
WITHDRAWN: Pharmacological interventions for non-ulcer dyspepsia. (21328253)
2011
24
WITHDRAWN: Psychological interventions for non-ulcer dyspepsia. (21328255)
2011
25
Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia. (20535327)
2010
26
Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial. (20670451)
2010
27
Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria. (20823838)
2010
28
Identification of lactic acid bacteria isolated from the fecal samples of healthy humans and patients with dyspepsia, and determination of their ph, bile, and antibiotic tolerance properties. (20668388)
2010
29
Functional dyspepsia: a pragmatic approach. (21180236)
2010
30
Differences in gastrointestinal symptoms according to gender in Rome II positive IBS and dyspepsia in a Latin American population. (20179693)
2010
31
Editorial: Reflux, dyspepsia, and Rome III (or Rome IV?). (21131930)
2010
32
Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics. (19432972)
2009
33
Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. (19460766)
2009
34
The Role of RANTES Promoter Polymorphism in Functional Dyspepsia. (19794934)
2009
35
Functional dyspepsia: Validation and results of a novel survey instrument to evaluate patient knowledge and perceptions. (19398925)
2009
36
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
37
Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia. (18807132)
2008
38
Clinical trial: effects of tegaserod on gastric motor and sensory function in patients with functional dyspepsia. (17892526)
2007
39
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
40
Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. (15866221)
2005
41
Initial management strategies for dyspepsia. (16235292)
2005
42
Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia. (15043521)
2004
43
Comparison of endoscopic gastric mucosa features after administration of piroxicam to meloxicam and their correlation with dyspepsia symptoms in elderly patient with knee osteoarthritis. (15673949)
2004
44
Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia. (12269975)
2002
45
Analysis of vacA, cagA, and IS605 genotypes and those determined by PCR amplification of DNA between repetitive sequences of Helicobacter pylori strains isolated from patients with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. (10364612)
1999
46
Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in nonulcer dyspepsia. (8185214)
1994
47
Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia? A preliminary report of buspirone/prolactin responses. (2359983)
1990
48
The role of milk and lactose intolerance in Ethiopian patients with non-ulcer dyspepsia: a case control study. (2787744)
1989
49
Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gallbladder disease and postcholecystectomy. (3557185)
1987
50
Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease. (3545953)
1986

Variations for Dyspepsia

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Expression for genes affiliated with Dyspepsia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Dyspepsia

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Dyspepsia according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4510.1CCK, CCKAR
2asperlicin4510.1CCK, CCKAR
3lorglumide45 2911.1CCKAR, CCK
4l3652604510.1CCKAR, CCK
5ym0224510.1CCK, CCKAR
6devazepide45 61 2912.1CCKAR, CCK
7caerulein4510.0CCKAR, CCK
8loxiglumide4510.0CCK, CCKAR
9decanoic acid45 29 1111.9CCK, GHRL
10octadecaneuropeptide459.9GHRL, CCK
11alosetron45 1110.9HTR3A, CCK
12aspartame45 24 1111.8CCK, TRPV1
13intralipid459.8CCKAR, GHRL, CCK
14granisetron51 45 1111.7CCK, HTR3A
15octreotide45 61 29 1112.7CCK, CCKAR, GHRL
16dexloxiglumide45 2910.7HTR3A, CCK, CCKAR
17benzodiazepine459.7HTR3A, CCKAR, CCK
18ondansetron51 45 24 1112.7CCK, CCKAR, HTR3A
19tegaserod45 29 1111.6HTR3A, CCK
20rimonabant45 29 1111.6CCK, GHRL
21bismuth45 2410.5CCKAR, HRH2
22quetiapine45 51 29 24 1113.5GHRL, HTR3A, ADRA2C
23thioperamide45 61 2911.5HRH2, HTR3A
24risperidone45 51 29 61 24 1114.5GHRL, HTR3A, ADRA2C
25cocaine45 1110.5GHRL, CCKAR, CCK
26olanzapine45 51 29 24 1113.5ADRA2C, HTR3A, GHRL
27morphine45 51 29 1112.5TRPV1, CCK, CCKAR
28clozapine45 29 51 1112.4ADRA2C, GHRL, HTR3A
29pepsinogen459.4CCK, HRH2
30carbohydrates459.4CCKAR, GHRL, CCK
31pramlintide45 1110.4GHRL, CCK
32omeprazole45 51 29 24 1113.3CCKAR, HRH2, CCK
33pirenzepine45 29 1111.3CCK, GHRL, HRH2
34amide459.3CCKAR, CCK, TRPV1, GHRL
35cisapride45 29 1111.2HTR3A, CCK, HRH2
36opiate459.2HRH2, GHRL, CCK
37metoclopramide45 51 1111.2CCK, HRH2, HTR3A
38acetaminophen45 3 51 24 1113.2HRH2, GHRL, CCK
39norepinephrine45 24 1111.1HTR3A, ADRA2C, GHRL, CCK
40atropine45 29 1111.0HRH2, GHRL, CCKAR, CCK
41benzodiazepines458.9HRH2, HTR3A, CCKAR, CCK
425-hydroxytryptamine458.8HTR3A, GHRL, CCK, HRH2
43gaba458.8CCKAR, TRPV1, GHRL, HTR3A, CCK
44histamine45 29 2410.8GHRL, HTR3A, HRH2, CCK
45acetylcholine45 51 29 24 1112.8HTR3A, CCK, HRH2, GHRL
46cholesterol45 29 24 1111.5HRH2, CCKAR, CCK, GHRL
47tetrodotoxin45 61 2910.4TRPV1, HRH2, HTR3A, CCKAR, CCK
48adenylate458.3HTR3A, GHRL, CCK, TRPV1, HRH2
49dopamine45 29 24 1111.3ADRA2C, CCK, HTR3A, GHRL, CCKAR, TRPV1
50forskolin45 51 1110.3HRH2, TRPV1, CCK, ADRA2C, GHRL

GO Terms for genes affiliated with Dyspepsia

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16Gene Ontology
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Cellular components related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.9HTR3A, GHRL, CCK
2plasma membraneGO:0058867.8ADRA2C, CCKAR, HTR3A, HRH2, TRPV1
3integral component of plasma membraneGO:0058877.7HRH2, ADRA2C, CCKAR, TRPV1, HTR3A

Biological processes related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:0072049.8GHRL, CCKAR
2digestionGO:0075869.7HTR3A, CCKAR
3regulation of sensory perception of painGO:0519309.7CCK, ADRA2C
4axonogenesisGO:0074099.6CCK, CCKAR
5neuron migrationGO:0017649.4CCKAR, CCK
6positive regulation of vasoconstrictionGO:0459079.2HRH2, ADRA2C

Products for genes affiliated with Dyspepsia

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Sources for Dyspepsia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet