MCID: DYS014
MIFTS: 52

Dyspepsia malady

Gastrointestinal category

Summaries for Dyspepsia

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Dyspepsia, also known as indigestion, is related to irritable bowel syndrome and duodenal ulcer. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Monoamine GPCRs and Gastric acid secretion. The compounds acetaminophen and lorglumide have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and brain, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:64 Dyspepsia (from the Greek δυσ- dys- and πέψις pepsis \"digestion\"), also known as indigestion,... more...

Aliases & Classifications for Dyspepsia

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 57SNOMED-CT, 35MeSH, 61UMLS, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

dyspepsia 8 10
indigestion 8 34
dyspepsia, indigestion nos 8
indigestion nos 8


External Ids:

Disease Ontology8 DOID:2321
MeSH35 D004415
NCIt40 C26756
ICD1025 K30

Related Diseases for Dyspepsia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dyspepsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.0HTR4, MLN, ATP4A, TRPV1, HTR3A, CCK
2duodenal ulcer30.7HRH2, GAST, S100A8
3gastroesophageal reflux disease30.7CCKAR, CCK, S100A8, GAST, MLN, ATP4A
4gastroparesis30.6CCK, HTR3A, HTR4, GAST, MLNR, MLN
5duodenitis30.4S100A8, GAST, ATP4A
6gastric ulcer30.4S100A8, GAST, GHRL, TRPV1, HRH2
7duodenogastric reflux30.2MLN, GAST, CCK
8bile reflux30.1CCK, ATP4A
9stomach cancer29.9CCK, S100A8, GAST, HRH2
10gastroduodenitis29.9GAST
11diabetic autonomic neuropathy29.9MLNR
12autonomic neuropathy29.9MLN, GAST, CCK
13h. pylori infection10.5
14sleep disorder10.2
15serotonin syndrome10.2
16bacterial gastritis10.1
17functional diarrhea10.1
18osteoarthritis10.1
19alexithymia10.1
20hyperparathyroidism10.0GAST
21eating disorder10.0GHRL
22acromegaly10.0CCK, GHRL
23pancreatitis10.0CCK, CCKAR
24postcholecystectomy syndrome10.0GAST
25cholecystitis10.0CCK
26gastric outlet obstruction10.0GAST, MLN, ATP4A
27ileus10.0MLNR, MLN, GHRL
28functional colonic disease10.0HTR4, MLNR
29zollinger-ellison syndrome10.0HRH2, GAST
30cholelithiasis10.0CCK
31pituitary adenoma10.0SSTR3, GHRL
32neuroma10.0TRPV1
33hypoglycemia10.0GAST, MLN, GHRL
34gallbladder disease10.0MLN, MLNR, CCK, CCKAR
35obsessive-compulsive disorder10.0HTR3A
36atrophic gastritis10.0S100A8, GAST, GHRL
37gastritis10.0GHRL, GAST, S100A8
38bulimia nervosa10.0GHRL, CCK
39diarrhea10.0HTR3A, GAST, MLN, ATP4A
40glucagonoma10.0CCK, GAST, GHRL
41constipation10.0CCK, HTR3A, HTR4, MLN
42anorexia nervosa10.0GHRL, HTR3A, CCK
43panic disorder10.0CCKAR, CCK, HTR3A
44hyperglycemia10.0CCK, MLN, GHRL
45thyroid medullary carcinoma10.0CCKAR, CCK, GAST, GHRL
46pain agnosia10.0CCKAR, CCK, HTR3A, TRPV1
47ischemia10.0MLN, GHRL, TRPV1, HRH2
48psychotic disorder10.0CCK, GNB3, HTR3A
49glucose intolerance10.0CCK, GAST, MLN, GHRL, HRH2
50pancreas disease10.0CCKAR, CCK, GAST

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to dyspepsia

Clinical Features for Dyspepsia

Drugs & Therapeutics for Dyspepsia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Dyspepsia

Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Search CenterWatch for Dyspepsia

Genetic Tests for Dyspepsia

Anatomical Context for Dyspepsia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Dyspepsia:

33
Liver, Tongue, Brain, Kidney, Lung, Spleen, Heart, Small intestine, Colon, Breast, T cells, B cells

Animal Models for Dyspepsia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Dyspepsia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0GAST, ATP4A, GHRL, IL17F, HRH2, NOX1
2MP:00053769.4ADRA2C, CCKAR, CCK, HTR3A, HTR4, GAST

Publications for Dyspepsia

Sources:
51PubMed
See all sources

Articles related to Dyspepsia:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. (23474421)
2014
2
Efficacy of permanent gastric electrical stimulation for the treatment of gastroparesis and functional dyspepsia in children and adolescents. (23331812)
2013
3
Impact of shiftwork on irritable bowel syndrome and functional dyspepsia. (23487413)
2013
4
Determination of relative frequency of eosinophils and mast cells in gastric and duodenal mucosal biopsies in adults with non-ulcer dyspepsia. (23673170)
2013
5
Letter: dyspepsia, anxiety and depression - authors' reply. (23205488)
2013
6
Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects. (22618805)
2013
7
Functional (non-ulcer) dyspepsia and gastroesophageal reflux disease: one not two diseases? (23644963)
2013
8
That dyspepsia in the young could be cancer. (23798802)
2013
9
Outcome of intestinal metaplasia in gastric biopsy of patients with dyspepsia in Guilan Province, North Iran. (23886143)
2013
10
Clinical characteristics and effectiveness of lansoprazole in Japanese patients with gastroesophageal reflux disease and dyspepsia. (23653056)
2013
11
Mechanisms of postprandial abdominal bloating and distension in functional dyspepsia. (23645627)
2013
12
Helicobacter Pylori "Test-and-Treat" Strategy for Management of Dyspepsia: A Comprehensive Review. (23535826)
2013
13
Prevalence of cagA, vacA, babA2 and iceA genes in H. pylori strains isolated from Colombian patients with functional dyspepsia. (22708344)
2012
14
The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia and influence on H. pylori eradication therapy. (23864462)
2012
15
Generation of dyspeptic symptoms by direct acid and water infusion into the stomachs of functional dyspepsia patients and healthy subjects. (22085402)
2012
16
Acupuncture effects on the pulse spectrum of radial pressure pulse in dyspepsia. (22745062)
2012
17
Comparison of PPIs and H2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia. (22509084)
2012
18
Darwinian dyspepsia, a more definitive diagnosis. (23034615)
2012
19
Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. (22813445)
2012
20
Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia. (22226326)
2012
21
Dyspepsia is strongly associated with major depression and generalised anxiety disorder - a community study. (22957985)
2012
22
WITHDRAWN: Psychological interventions for non-ulcer dyspepsia. (21328255)
2011
23
Validation study of the Leeds Dyspepsia Questionnaire in a multi-ethnic Asian population. (21649731)
2011
24
Proton-pump inhibitors for the treatment of functional dyspepsia. (21765866)
2011
25
Dyspepsia (indigestion). (21391522)
2011
26
Gradual cessation of proton pump inhibitor (PPI) treatment may prevent rebound acid secretion, measured by the alkaline tide method, in dyspepsia and reflux patients. (21723045)
2011
27
Laboratory parameters and nutritional status in patients with functional dyspepsia. (21570652)
2011
28
Effect of ginger on gastric motility and symptoms of functional dyspepsia. (21218090)
2011
29
Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia. (20535327)
2010
30
Identification of lactic acid bacteria isolated from the fecal samples of healthy humans and patients with dyspepsia, and determination of their ph, bile, and antibiotic tolerance properties. (20668388)
2010
31
Antidepressants in functional dyspepsia. (20136584)
2010
32
Clinical practice: diagnosis and evaluation of dyspepsia. (20009950)
2010
33
GERD: are functional heartburn and functional dyspepsia one disorder? (20134484)
2010
34
Clinical trial: prolonged beneficial effect of Helicobacter pylori eradication on dyspepsia consultations - the Bristol Helicobacter Project. (20491744)
2010
35
New epidemiologic evidence on functional dyspepsia subgroups and their relationship to psychosocial dysfunction. (19482100)
2009
36
Managing dyspepsia in primary care. (19938559)
2009
37
Central opioid peptide-containing neurons mediates therapeutic effect of short-pulse gastric electrical stimulation on dyspepsia-like symptoms in dogs. (20037810)
2009
38
Analysis of the gastrointestinal symptoms of uninvestigated dyspepsia and irritable bowel syndrome. (20431745)
2009
39
Acupuncture for dyspepsia in pregnancy: a prospective, randomised, controlled study. (19502459)
2009
40
Atypical dyspepsia. Gastrointestinal stromal tumour. (19671556)
2009
41
The influence of alexithymia on persistent symptoms of dyspepsia after laparoscopic cholecystectomy. (17953235)
2007
42
Cholecystokinin hyperresponsiveness in functional dyspepsia. (16718754)
2006
43
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
44
Gastrointestinal hormone abnormalities and G and D cells in functional dyspepsia patients with gastric dysmotility. (15637765)
2005
45
Dyspepsia and gastroparesis in chronic renal failure: the role of Helicobacter pylori. (11924751)
2002
46
Analysis of vacA, cagA, and IS605 genotypes and those determined by PCR amplification of DNA between repetitive sequences of Helicobacter pylori strains isolated from patients with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. (10364612)
1999
47
Cisapride versus metoclopramide in the treatment of functional dyspepsia. A double-blind comparative trial. (8128175)
1994
48
Gastroduodenal reflux and non-ulcerous dyspepsia. Is it an accidental association?]. (1929203)
1991
49
Is gastroduodenitis a cause of chronic dyspepsia? (1896828)
1991
50
Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease. (3545953)
1986

Genetic Variations for Dyspepsia

Expression for genes affiliated with Dyspepsia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 30KEGG
See all sources

Compounds for genes affiliated with Dyspepsia

Sources:
45Novoseek, 2BitterDB, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Dyspepsia according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1acetaminophen45 2 50 11 2414.8HRH2, GHRL
2lorglumide45 2911.7CCKAR, GAST, CCK
3l3652604510.7CCKAR, CCK, GAST
4ym0224510.7CCKAR, GAST, CCK
5dexloxiglumide45 2911.7MLN, HTR3A, CCKAR, CCK
6benzodiazepines4510.7HRH2, HTR3A, CCK, CCKAR
7ranitidine45 29 11 2413.7HRH2, MLN, CCK
8devazepide45 29 6012.7CCKAR, CCK, GAST
9caerulein4510.6MLN, CCK, CCKAR
10prucalopride45 2911.6HTR3A, HTR4, MLN
11pirenzepine45 29 1112.6HRH2, GHRL, GAST, CCK
12tegaserod45 29 1112.6MLN, HTR3A, CCK, HTR4
13bismuth45 2411.6GAST, HRH2, CCKAR
14loxiglumide4510.6CCKAR, CCK, GAST
15lafutidine4510.6GAST, HRH2, MLN
16oxyntomodulin45 6011.6CCK, GAST, MLN, GHRL
17pepsinogen4510.6CCK, HRH2, GAST
18granisetron45 1111.6CCK, HTR3A, HTR4
19metoclopramide45 1111.6MLN, HTR3A, CCK, HRH2, HTR4
20amide4510.6CCK, GAST, TRPV1, GHRL, CCKAR
21erythromycin45 50 2 1113.6GHRL, MLNR, GAST, CCKAR, MLN
22yohimbine45 29 2 1113.5ADRA2C, GAST, HTR4, HTR3A
23tetrodotoxin45 60 2912.5TRPV1, HTR3A, MLN, CCK, HRH2, CCKAR
24bethanechol45 29 1112.5GAST, CCK, MLN
25ondansetron45 50 11 2413.5HTR4, CCKAR, CCK, HTR3A, GAST, MLN
26cisapride45 29 1112.5HRH2, MLN, MLNR, CCK, HTR4, HTR3A
27octreotide45 60 29 1113.5CCKAR, CCK, SSTR3, GAST, MLN, GHRL
28olanzapine50 45 29 11 2414.5HTR3A, GNB3, ADRA2C, GHRL
29famotidine45 2 11 2413.5MLN, GHRL, HRH2, GAST
30gaba4510.5GHRL, TRPV1, GAST, HTR3A, CCK, CCKAR
31amoxicillin45 50 1112.5HRH2, GAST, S100A8
32atropine45 29 1112.4HTR4, HRH2, GHRL, GAST, MLN, CCK
33omeprazole45 29 50 11 2414.4CCK, GAST, MLN, ATP4A, HRH2, S100A8
34pantoprazole45 50 11 2413.4ATP4A, GAST, HRH2
355-hydroxytryptamine4510.4CCK, HRH2, GAST, HTR4, HTR3A, MLN
36histamine45 29 2412.4HTR3A, CCK, S100A8, GAST, MLN, HRH2
37acetylcholine45 50 29 11 2414.4HRH2, HTR3A, GHRL, MLN, GAST, HTR4
38norepinephrine45 11 2412.4CCK, GNB3, GAST, HTR3A, GHRL, ADRA2C
39domperidone45 29 1112.4HRH2, MLN, GAST
40adenylate4510.3MLN, CCK, HTR3A, GAST, TRPV1, HRH2
41acth4510.3CCK, GHRL, MLN, GAST, HTR4
42lansoprazole50 45 11 2413.3GAST, HRH2, ATP4A
43dopamine45 29 11 2413.3MLN, CCKAR, ADRA2C, TRPV1, GHRL, MLNR
44intralipid4510.3CCKAR, GHRL, CCK
45cholesterol45 29 11 2413.3CCK, GHRL, CCKAR, MLN, HRH2, GNB3
46hydrogen45 2411.2HRH2, TRPV1, NOX1, GHRL, MLN, GAST
47clozapine45 29 50 1113.1ADRA2C, HTR3A, GHRL, GNB3
48tyrosine4510.0GHRL, OCM2, TRPV1, CCK, S100A8, GAST
49glutamate4510.0GAST, CCK, S100A8, TRPV1, OCM2, GHRL
50nitric oxide45 11 2411.7HRH2, S100A8, GNB3, MLN, GHRL, TRPV1

GO Terms for genes affiliated with Dyspepsia

Sources:
16Gene Ontology
See all sources

Cellular components related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8CCKAR, S100A8, GNB3, HTR3A, HTR4, MLNR
2integral to plasma membraneGO:0058879.5CCKAR, HTR3A, HTR4, MLNR, ATP4A, SSTR3

Biological processes related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of sensory perception of painGO:05193010.4ADRA2C, CCK
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.2HTR4, SSTR3, HRH2
3digestionGO:00758610.2MLNR, HTR3A, CCKAR
4serotonin receptor signaling pathwayGO:00721010.0HTR4, HTR3A
5G-protein coupled receptor signaling pathwayGO:00718610.0ADRA2C, GHRL, MLN, MLNR, GAST, HTR4

Molecular functions related to Dyspepsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3MLN, GAST, CCK

Products for genes affiliated with Dyspepsia

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Dyspepsia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet