MCID: DYS014
MIFTS: 45

Dyspepsia malady

Gastrointestinal diseases category

Summaries for Dyspepsia

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MedlinePlus:32 Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Dyspepsia, also known as indigestion, is related to irritable bowel syndrome and gastroparesis. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Monoamine GPCRs. The compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Wikipedia:63 Dyspepsia (from the Greek ???- dys-, \"bad\" or \"difficult\", and ????? pepsis \"digestion\"), also... more...

Aliases & Classifications for Dyspepsia

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Dyspepsia, Aliases & Descriptions:

Name: Dyspepsia 9 11
Indigestion 9 32
 
Dyspepsia, Indigestion Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:2321
NCIt38 C26756
MeSH33 D004415
ICD1025 K30

Related Diseases for Dyspepsia

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Diseases related to Dyspepsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.1CCK, HTR3A, TRPV1
2gastroparesis30.9CCK, GHRL, HTR3A
3duodenal ulcer30.8CCK, HRH2
4eating disorder30.8GHRL
5gallbladder disease30.7CCK, CCKAR
6peptic ulcer disease30.7HRH2, CCK
7anxiety disorder30.4HTR3A, CCK
8celiac disease30.4GHRL, CCK
9gastroesophageal reflux30.4CCK, CCKAR, HRH2, TRPV1
10constipation30.3HTR3A, CCK
11pancreatitis30.3CCKAR, CCK
12gastritis30.2CCK, GHRL, TRPV1, HRH2
13migraine30.2HTR3A, TRPV1
14esophagitis30.2TRPV1, HRH2
15obesity29.8CCK, CCKAR, GHRL, TRPV1
16gastric ulcer29.7HRH2, TRPV1, GHRL
17asthma29.5HRH2, GHRL, TRPV1
18duodenitis10.7
19blindness10.5
20h. pylori infection10.3
21bulimia nervosa10.3GHRL, CCK
22morbid obesity10.3CCK, GHRL
23pancreas disease10.3CCK, CCKAR
24glucagonoma10.3GHRL, CCK
25eosinophilia10.3
26sleep disorder10.3
27prader-willi syndrome10.2GHRL, CCK
28acromegaly10.2CCK, GHRL
29nutritional deficiency disease10.2GHRL, CCK
30psychotic disorder10.2CCK, HTR3A
31neuroendocrine tumor10.2CCK, GHRL
32gastroduodenitis10.2
33atrial fibrillation10.2
34cholestasis10.2CCK, HTR3A
35bacterial gastritis10.2
36medullary thyroid carcinoma, familial10.2CCK, CCKAR, GHRL
37panic disorder10.1HTR3A, CCKAR, CCK
38diabetes mellitus, noninsulin-dependent10.1GHRL, CCKAR, CCK
39anorexia nervosa10.1GHRL, CCK, HTR3A
40carcinoid syndrome10.1CCK, GHRL, HTR3A
41epilepsy syndrome10.1HTR3A, GHRL, CCK
42diabetes mellitus, insulin-dependent10.1GHRL, CCK, CCKAR
43osteoarthritis10.1
44alexithymia10.1
45neuronitis10.1
46duodenogastric reflux10.1
47cerebritis10.1
48bile reflux10.1
49diarrhea10.1
50gastroenteritis10.1

Graphical network of the top 20 diseases related to Dyspepsia:



Diseases related to dyspepsia

Symptoms for Dyspepsia

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Drugs & Therapeutics for Dyspepsia

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Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Genetic Tests for Dyspepsia

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Anatomical Context for Dyspepsia

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MalaCards organs/tissues related to Dyspepsia:

31
Testes, Kidney, Brain, Spleen, Heart, Tongue, Small intestine, Colon, Liver, Lung, Breast, T cells, Neutrophil

Animal Models for Dyspepsia or affiliated genes

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MGI Mouse Phenotypes related to Dyspepsia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9GHRL, HTR3A, CCKAR, CCK
2MP:00053867.3ADRA2C, CCKAR, HTR3A, GHRL, HRH2, TRPV1
3MP:00036317.1ADRA2C, CCK, CCKAR, HTR3A, HRH2, TRPV1
4MP:00053767.0TRPV1, ADRA2C, CCK, CCKAR, HTR3A, GHRL

Publications for Dyspepsia

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Articles related to Dyspepsia:

(show top 50)    (show all 647)
idTitleAuthorsYear
1
Primary abdominal tuberculosis presenting as chronic dyspepsia. (25758687)
2015
2
Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease. (25657274)
2015
3
Treatment of functional dyspepsia and gastroparesis. (25169218)
2014
4
Impact of Microscopic Duodenitis on Symptomatic Response to Helicobacter pylori Eradication in Functional Dyspepsia. (25102980)
2014
5
CagA and VacA genotypes in peptic ulcer disease and non-ulcer dyspepsia: a case-control study. (25664305)
2014
6
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
7
Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis. (24330675)
2013
8
Functional dyspepsia: the economic impact to patients. (23725230)
2013
9
The role of psychosocial factors and psychiatric disorders in functional dyspepsia. (23358396)
2013
10
Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study. (24179567)
2013
11
Decreased Basal and postprandial plasma serotonin levels in patients with functional dyspepsia. (23591288)
2013
12
Duodenal eosinophilia and Early Satiety in Functional Dyspepsia: Confirmation of a Positive Association in an Australian Cohort. (24304041)
2013
13
Clinically significant endoscopic findings in a multi-ethnic population with uninvestigated dyspepsia. (22688184)
2012
14
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
15
The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test. (22160229)
2012
16
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
17
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
18
Asian consensus report on functional dyspepsia: necessary and ready? (22436057)
2012
19
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
20
Prevalence of cagA, vacA, babA2 and iceA genes in H. pylori strains isolated from Colombian patients with functional dyspepsia. (22708344)
2012
21
Dyspepsia: Acotiamide can relieve symptoms of functional dyspepsia. (22249733)
2012
22
Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole--results from the STARS II study. (21848799)
2011
23
Randomised clinical trial: identification of responders to short-term treatment with esomeprazole for dyspepsia in primary care - a randomised, placebo-controlled study. (21083590)
2011
24
The role of Acid in functional dyspepsia. (21637272)
2011
25
Clinical and epidemiological perspectives of dyspepsia in a multiracial Malaysian population. (21443706)
2011
26
WITHDRAWN: Pharmacological interventions for non-ulcer dyspepsia. (21328253)
2011
27
Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia. (20535327)
2010
28
Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial. (20670451)
2010
29
Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria. (20823838)
2010
30
Identification of lactic acid bacteria isolated from the fecal samples of healthy humans and patients with dyspepsia, and determination of their ph, bile, and antibiotic tolerance properties. (20668388)
2010
31
Functional dyspepsia: a pragmatic approach. (21180236)
2010
32
Differences in gastrointestinal symptoms according to gender in Rome II positive IBS and dyspepsia in a Latin American population. (20179693)
2010
33
Editorial: Reflux, dyspepsia, and Rome III (or Rome IV?). (21131930)
2010
34
Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics. (19432972)
2009
35
Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. (19460766)
2009
36
The Role of RANTES Promoter Polymorphism in Functional Dyspepsia. (19794934)
2009
37
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
38
Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia. (18807132)
2008
39
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
40
Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. (15866221)
2005
41
Initial management strategies for dyspepsia. (16235292)
2005
42
Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia. (15043521)
2004
43
Comparison of endoscopic gastric mucosa features after administration of piroxicam to meloxicam and their correlation with dyspepsia symptoms in elderly patient with knee osteoarthritis. (15673949)
2004
44
Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia. (12269975)
2002
45
Analysis of vacA, cagA, and IS605 genotypes and those determined by PCR amplification of DNA between repetitive sequences of Helicobacter pylori strains isolated from patients with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. (10364612)
1999
46
Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in nonulcer dyspepsia. (8185214)
1994
47
Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia? A preliminary report of buspirone/prolactin responses. (2359983)
1990
48
The role of milk and lactose intolerance in Ethiopian patients with non-ulcer dyspepsia: a case control study. (2787744)
1989
49
Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gallbladder disease and postcholecystectomy. (3557185)
1987
50
Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease. (3545953)
1986

Variations for Dyspepsia

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Expression for genes affiliated with Dyspepsia

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Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

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Compounds for genes affiliated with Dyspepsia

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Compounds related to Dyspepsia according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4310.1CCK, CCKAR
2asperlicin4310.1CCK, CCKAR
3lorglumide43 2811.1CCKAR, CCK
4l3652604310.1CCKAR, CCK
5ym0224310.1CCK, CCKAR
6devazepide43 59 2812.1CCKAR, CCK
7caerulein4310.0CCKAR, CCK
8loxiglumide4310.0CCK, CCKAR
9decanoic acid43 28 1211.9CCK, GHRL
10octadecaneuropeptide439.9GHRL, CCK
11alosetron43 1210.9HTR3A, CCK
12aspartame43 24 1211.8CCK, TRPV1
13intralipid439.8CCKAR, GHRL, CCK
14granisetron49 43 1211.7CCK, HTR3A
15octreotide43 59 28 1212.7CCK, CCKAR, GHRL
16dexloxiglumide43 2810.7HTR3A, CCK, CCKAR
17benzodiazepine439.7HTR3A, CCKAR, CCK
18ondansetron49 43 24 1212.7CCK, CCKAR, HTR3A
19tegaserod43 28 1211.6HTR3A, CCK
20rimonabant43 28 1211.6CCK, GHRL
21bismuth43 2410.5CCKAR, HRH2
22quetiapine43 49 28 24 1213.5GHRL, HTR3A, ADRA2C
23thioperamide43 59 2811.5HRH2, HTR3A
24risperidone43 49 28 59 24 1214.5GHRL, HTR3A, ADRA2C
25cocaine43 1210.5GHRL, CCKAR, CCK
26olanzapine43 49 28 24 1213.5ADRA2C, HTR3A, GHRL
27morphine43 49 28 1212.5TRPV1, CCK, CCKAR
28clozapine43 28 49 1212.4ADRA2C, GHRL, HTR3A
29pepsinogen439.4CCK, HRH2
30carbohydrates439.4CCKAR, GHRL, CCK
31pramlintide43 1210.4GHRL, CCK
32omeprazole43 49 28 24 1213.3CCKAR, HRH2, CCK
33pirenzepine43 28 1211.3CCK, GHRL, HRH2
34amide439.3CCKAR, CCK, TRPV1, GHRL
35cisapride43 28 1211.2HTR3A, CCK, HRH2
36opiate439.2HRH2, GHRL, CCK
37metoclopramide43 49 1211.2CCK, HRH2, HTR3A
38acetaminophen43 2 49 24 1213.2HRH2, GHRL, CCK
39norepinephrine43 24 1211.1HTR3A, ADRA2C, GHRL, CCK
40atropine43 28 1211.0HRH2, GHRL, CCKAR, CCK
41benzodiazepines438.9HRH2, HTR3A, CCKAR, CCK
425-hydroxytryptamine438.8HTR3A, GHRL, CCK, HRH2
43gaba438.8CCKAR, TRPV1, GHRL, HTR3A, CCK
44histamine43 28 2410.8GHRL, HTR3A, HRH2, CCK
45acetylcholine43 49 28 24 1212.8HTR3A, CCK, HRH2, GHRL
46cholesterol43 28 24 1211.5HRH2, CCKAR, CCK, GHRL
47tetrodotoxin43 59 2810.4TRPV1, HRH2, HTR3A, CCKAR, CCK
48adenylate438.3HTR3A, GHRL, CCK, TRPV1, HRH2
49dopamine43 28 24 1211.3ADRA2C, CCK, HTR3A, GHRL, CCKAR, TRPV1
50forskolin43 49 1210.3HRH2, TRPV1, CCK, ADRA2C, GHRL

GO Terms for genes affiliated with Dyspepsia

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Cellular components related to Dyspepsia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304248.9HTR3A, GHRL, CCK
2plasma membraneGO:00058867.8ADRA2C, CCKAR, HTR3A, HRH2, TRPV1
3integral component of plasma membraneGO:00058877.7HRH2, ADRA2C, CCKAR, TRPV1, HTR3A

Biological processes related to Dyspepsia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:00072049.8GHRL, CCKAR
2digestionGO:00075869.7HTR3A, CCKAR
3regulation of sensory perception of painGO:00519309.7CCK, ADRA2C
4axonogenesisGO:00074099.6CCK, CCKAR
5neuron migrationGO:00017649.4CCKAR, CCK
6positive regulation of vasoconstrictionGO:00459079.2HRH2, ADRA2C

Products for genes affiliated with Dyspepsia

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Sources for Dyspepsia

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