Dyspepsia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Dyspepsia

Sources:
³³MedlinePlus, ⁶⁴Wikipedia, ³²MalaCards
See all sources

MedlinePlus:³³ Nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Dyspepsia, also known as indigestion, is related to irritable bowel syndrome and gastroparesis. An important gene associated with Dyspepsia is CCKAR (cholecystokinin A receptor), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Monoamine GPCRs. The compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Wikipedia:⁶⁴ Dyspepsia (from the Greek ???- dys-, \"bad\" or \"difficult\", and ????? pepsis \"digestion\"), also... more...

Aliases & Classifications for Dyspepsia

Sources:
⁹Disease Ontology, ¹¹DISEASES, ³³MedlinePlus, ³⁹NCIt, ⁵⁶SNOMED-CT, ³⁴MeSH, ⁶¹UMLS, ²⁶ICD10
See all sources

Dyspepsia, Aliases & Descriptions:

Name: Dyspepsia ⁹ ¹¹

Indigestion ⁹ ³³

Dyspepsia, Indigestion Nos ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases

ICD10: ²⁶

Diseases of the digestive system

Diseases of oesophagus, stomach and duodenum

Dyspepsia

External Ids:

Disease Ontology⁹ DOID:2321

NCIt³⁹ C26756

SNOMED-CT⁵⁶ 162031009, 196752002, 139299007 249510006, 87548005, 266505001, 155722007, more

MeSH³⁴ D004415

ICD10²⁶ K30

UMLS⁶¹ C0013395

Related Diseases for Dyspepsia

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Dyspepsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 95)

id	Related Disease	Score	Top Affiliating Genes
1	irritable bowel syndrome	31.1	CCK, HTR3A, TRPV1
2	gastroparesis	30.9	CCK, HTR3A, GHRL
3	eating disorder	30.8	GHRL
4	duodenal ulcer	30.8	CCK, HRH2
5	gallbladder disease	30.7	CCKAR, CCK
6	peptic ulcer disease	30.5	CCK, HRH2
7	celiac disease	30.4	GHRL, CCK
8	migraine	30.4	TRPV1, HTR3A
9	gastroesophageal reflux disease	30.3	CCK, CCKAR, HRH2, TRPV1
10	constipation	30.3	CCK, HTR3A
11	pancreatitis	30.3	CCKAR, CCK
12	anxiety disorder	30.2	HTR3A, CCK
13	gastritis	30.2	TRPV1, HRH2, GHRL, CCK
14	esophagitis	30.2	TRPV1, HRH2
15	diabetes mellitus	30.0	GHRL, CCKAR, CCK
16	obesity	29.8	CCK, CCKAR, GHRL, TRPV1
17	gastric ulcer	29.8	GHRL, HRH2, TRPV1
18	stomach cancer	29.7	HRH2, GHRL, CCKAR
19	asthma	29.5	GHRL, HRH2, TRPV1
20	duodenitis	10.7
21	blindness	10.5
22	h. pylori infection	10.4
23	double outlet right ventricle	10.3	CCK, GHRL
24	pancreas disease	10.3	CCK, CCKAR
25	morbid obesity	10.3	GHRL, CCK
26	glucagonoma	10.3	CCK, GHRL
27	eosinophilia	10.3
28	sleep disorder	10.3
29	prader-willi syndrome	10.2	GHRL, CCK
30	acromegaly	10.2	CCK, GHRL
31	neuroendocrine tumor	10.2	GHRL, CCK
32	psychotic disorder	10.2	HTR3A, CCK
33	gastroduodenitis	10.2
34	cholestasis	10.2	HTR3A, CCK
35	bacterial gastritis	10.2
36	thyroid medullary carcinoma	10.2	CCK, CCKAR, GHRL
37	panic disorder	10.1	CCK, CCKAR, HTR3A
38	type 2 diabetes mellitus	10.1	CCK, CCKAR, GHRL
39	bulimia nervosa	10.1	GHRL, HTR3A, CCK
40	anorexia nervosa	10.1	GHRL, HTR3A, CCK
41	carcinoid syndrome	10.1	GHRL, HTR3A, CCK
42	epilepsy syndrome	10.1	GHRL, HTR3A, CCK
43	gastric cancer	10.1
44	osteoarthritis	10.1
45	bile reflux	10.1
46	alexithymia	10.1
47	neuronitis	10.1
48	duodenogastric reflux	10.1
49	diarrhea	10.1
50	gastroenteritis	10.1

Graphical network of the top 20 diseases related to Dyspepsia:

Symptoms for Dyspepsia

Drugs & Therapeutics for Dyspepsia

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Dyspepsia

Search NIH Clinical Center for Dyspepsia

Genetic Tests for Dyspepsia

Anatomical Context for Dyspepsia

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Dyspepsia:

³²

Testes, Kidney, Brain, Spleen, Tongue, Heart, Small intestine, Colon, Liver, Lung, Breast, T cells, Neutrophil

Animal Models for Dyspepsia or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Dyspepsia:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.9	GHRL, HTR3A, CCKAR, CCK
2	behavior/neurological phenotype	MP:0005386	7.3	ADRA2C, CCKAR, HTR3A, GHRL, HRH2, TRPV1
3	nervous system phenotype	MP:0003631	7.1	ADRA2C, CCK, CCKAR, HTR3A, HRH2, TRPV1
4	homeostasis/metabolism phenotype	MP:0005376	7.0	TRPV1, ADRA2C, CCK, CCKAR, HTR3A, GHRL

Publications for Dyspepsia

Sources:
⁵¹PubMed
See all sources

Articles related to Dyspepsia:

(show top 50) (show all 628)

id	Title	Authors	Year
1	Treatment of functional dyspepsia and gastroparesis. (25169218)	Stein B.... Lacy B.E.	2014
2	Impact of Microscopic Duodenitis on Symptomatic Response to Helicobacter pylori Eradication in Functional Dyspepsia. (25102980)	Mirbagheri S.S.... Safa H.	2014
3	Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats. (23142231)	Winston J.H.... Sarna S.K.	2013
4	Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)	Yeom J.S.... Rhee K.H.	2013
5	Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis. (24330675)	Salles Junior L.D.... de Souza M.H.	2013
6	Functional dyspepsia: the economic impact to patients. (23725230)	Lacy B.E.... Talley N.J.	2013
7	The role of psychosocial factors and psychiatric disorders in functional dyspepsia. (23358396)	Van Oudenhove L.... Aziz Q.	2013
8	Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study. (24179567)	Xu S.... Hou X.	2013
9	Decreased Basal and postprandial plasma serotonin levels in patients with functional dyspepsia. (23591288)	Cheung C.K.... Wu J.C.	2013
10	Duodenal eosinophilia and Early Satiety in Functional Dyspepsia: Confirmation of a Positive Association in an Australian Cohort. (24304041)	Walker M.... Talley N.	2013
11	Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach. (23865590)	Valle P.C.... Paulssen E.J.	2013
12	Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria. (23399526)	Tack J.... Talley N.J.	2013
13	Clinically significant endoscopic findings in a multi-ethnic population with uninvestigated dyspepsia. (22688184)	Mahadeva S.... Goh K.L.	2012
14	Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)	Park M.I.	2012
15	The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test. (22160229)	Braak B.... Boeckxstaens G.E.	2012
16	Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)	Lee K.J.	2012
17	Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)	Nwokediuko S.C.... Obienu O.	2012
18	Asian consensus report on functional dyspepsia: necessary and ready? (22436057)	Wu J.C.	2012
19	Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)	Borg J.... Ohlsson B.	2012
20	Prevalence of cagA, vacA, babA2 and iceA genes in H. pylori strains isolated from Colombian patients with functional dyspepsia. (22708344)	ArAcvalo-Galvis A.... Poutou-PiA+ales R.A.	2012
21	Dyspepsia: Acotiamide can relieve symptoms of functional dyspepsia. (22249733)	McLarnon A.	2012
22	Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole--results from the STARS II study. (21848799)	van Zanten S.V.... Bolling-Sternevald E.	2011
23	Randomised clinical trial: identification of responders to short-term treatment with esomeprazole for dyspepsia in primary care - a randomised, placebo-controlled study. (21083590)	Meineche-Schmidt V.... Bytzer P.	2011
24	The role of Acid in functional dyspepsia. (21637272)	Savarino E.... Savarino V.	2011
25	Clinical and epidemiological perspectives of dyspepsia in a multiracial Malaysian population. (21443706)	Goh K.L.	2011
26	WITHDRAWN: Pharmacological interventions for non-ulcer dyspepsia. (21328253)	Moayyedi P.... Forman D.	2011
27	Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia. (20535327)	Tse A.W.... Wu J.C.	2010
28	Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial. (20670451)	Park J.W.... Kim J.	2010
29	Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria. (20823838)	Xiao Y.L.... Chen M.H.	2010
30	Identification of lactic acid bacteria isolated from the fecal samples of healthy humans and patients with dyspepsia, and determination of their ph, bile, and antibiotic tolerance properties. (20668388)	KiliAs G.B.... Karahan A.G.	2010
31	Functional dyspepsia: a pragmatic approach. (21180236)	Giurcan R.... Voiosu T.A.	2010
32	Differences in gastrointestinal symptoms according to gender in Rome II positive IBS and dyspepsia in a Latin American population. (20179693)	Schmulson M.... Chang L.	2010
33	Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics. (19432972)	Friesen C.A.... Abdel-Rahman S.M.	2009
34	Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. (19460766)	Savarino E.... Savarino V.	2009
35	The Role of RANTES Promoter Polymorphism in Functional Dyspepsia. (19794934)	Tahara T.... Arisawa T.	2009
36	Functional dyspepsia: Validation and results of a novel survey instrument to evaluate patient knowledge and perceptions. (19398925)	Kennedy A.T.... Lacy B.E.	2009
37	Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)	Tuteja A.K.... Hale D.C.	2008
38	Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia. (18807132)	Erzin Y.... Kocazeybek B.	2008
39	Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)	Sinha S.K.... Joshi K.	2005
40	Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. (15866221)	Andersen L.P.... WadstrAPm T.	2005
41	Initial management strategies for dyspepsia. (16235292)	Delaney B.... Qume M.	2005
42	Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia. (15043521)	Kamerling I.M.... Burggraaf J.	2004
43	Comparison of endoscopic gastric mucosa features after administration of piroxicam to meloxicam and their correlation with dyspepsia symptoms in elderly patient with knee osteoarthritis. (15673949)	Girawan D.... Pramudiyo R.	2004
44	Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia. (12269975)	Yoshikawa I.... Otsuki M.	2002
45	Analysis of vacA, cagA, and IS605 genotypes and those determined by PCR amplification of DNA between repetitive sequences of Helicobacter pylori strains isolated from patients with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. (10364612)	van Doorn N.E.... Vandenbroucke-Grauls C.M.	1999
46	Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in nonulcer dyspepsia. (8185214)	Chua A.S.... Keeling P.W.	1994
47	Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia? A preliminary report of buspirone/prolactin responses. (2359983)	Dinan T.G.... Keeling P.W.	1990
48	The role of milk and lactose intolerance in Ethiopian patients with non-ulcer dyspepsia: a case control study. (2787744)	Tsega E.... Tedla B.	1989
49	Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gallbladder disease and postcholecystectomy. (3557185)	Watson R.G.... Love A.H.	1987
50	Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease. (3545953)	Watson R.G.... Love A.H.	1986

Genes related to Dyspepsia

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Dyspepsia:

- Elite gene

id	Symbol	Description	Score	Implication
1	CCKAR	cholecystokinin A receptor	21.21	GeneCards inferred via : Publications, Disorders (show sections)
2	GHRL	ghrelin/obestatin prepropeptide	18.71	GeneCards inferred via : Publications, Disorders (show sections)
3	CCK	cholecystokinin	16.21	GeneCards inferred via : Publications, Disorders (show sections)
4	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	13.71	GeneCards inferred via : Publications, Disorders (show sections)
5	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.21	GeneCards inferred via : Publications, Disorders (show sections)
6	MIR325	microRNA 325	8.66	GeneCards inferred via : Publications (show sections)
7	HRH2	histamine receptor H2	6.15	GeneCards inferred via : Publications, Disorders (show sections)
8	ADRA2C	adrenoceptor alpha 2C	3.65	GeneCards inferred via : Publications (show sections)

Products for genes related to Dyspepsia disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	7	7
2	Novus Biologicals	5	7	7	-

Variations for Dyspepsia

Expression for genes affiliated with Dyspepsia

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Pathways for genes affiliated with Dyspepsia

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ³⁰KEGG
See all sources

Pathways related to Dyspepsia according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Gastrin-CREB signalling pathway via PKC and MAPK⁵⁴ Show member pathways G alpha (q) signalling events⁵⁴	9.3	CCK, CCKAR, GHRL
2	Monoamine GPCRs³⁷ Show member pathways Serotonin receptors⁵⁴ Adrenoceptors⁵⁴ Histamine receptors⁵⁴ Adrenaline signalling through Alpha-2 adrenergic receptor⁵⁴ Dopamine receptors⁵⁴ Muscarinic acetylcholine receptors⁵⁴ Amine ligand-binding receptors⁵⁴	9.1	HRH2, ADRA2C
3	Signaling by GPCR⁵⁴ Show member pathways GPCR downstream signaling⁵⁴ Signal Transduction⁵⁴	8.0	HRH2, GHRL, CCKAR, CCK, ADRA2C
4	Peptide ligand-binding receptors⁵⁴ Show member pathways Vasopressin-like receptors⁵⁴ Relaxin receptors⁵⁴ Formyl peptide receptors bind formyl peptides and many other ligands⁵⁴ GPCRs, Class A Rhodopsin-like³⁷ Class A/1 (Rhodopsin-like receptors)⁵⁴ GPCR ligand binding⁵⁴ Neuroactive ligand-receptor interaction³⁰ G alpha (i) signalling events⁵⁴ Orexin and neuropeptides FF and QRFP bind to their respective receptors⁵⁴ Tachykinin receptors bind tachykinins⁵⁴	7.5	TRPV1, HRH2, GHRL, CCKAR, CCK, ADRA2C

Compounds for genes affiliated with Dyspepsia

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ⁶⁰Tocris Bioscience, ¹²DrugBank, ²⁵HMDB, ⁵⁰PharmGKB, ³BitterDB
See all sources

Compounds related to Dyspepsia according to GeneCards/GeneDecks:

(show top 50) (show all 87)

id	Compound	Score	Top Affiliating Genes
1	1,4-benzodiazepine⁴⁴	10.1	CCK, CCKAR
2	asperlicin⁴⁴	10.1	CCK, CCKAR
3	lorglumide⁴⁴ ²⁹	11.1	CCK, CCKAR
4	l365260⁴⁴	10.1	CCK, CCKAR
5	ym022⁴⁴	10.1	CCK, CCKAR
6	devazepide⁴⁴ ⁶⁰ ²⁹	12.1	CCK, CCKAR
7	caerulein⁴⁴	10.0	CCKAR, CCK
8	loxiglumide⁴⁴	10.0	CCK, CCKAR
9	decanoic acid⁴⁴ ²⁹ ¹²	11.9	CCK, GHRL
10	octadecaneuropeptide⁴⁴	9.9	CCK, GHRL
11	alosetron⁴⁴ ¹²	10.9	CCK, HTR3A
12	aspartame⁴⁴ ²⁵ ¹²	11.8	TRPV1, CCK
13	intralipid⁴⁴	9.8	GHRL, CCKAR, CCK
14	granisetron⁵⁰ ⁴⁴ ¹²	11.7	HTR3A, CCK
15	octreotide⁴⁴ ⁶⁰ ²⁹ ¹²	12.7	GHRL, CCKAR, CCK
16	dexloxiglumide⁴⁴ ²⁹	10.7	HTR3A, CCKAR, CCK
17	benzodiazepine⁴⁴	9.7	HTR3A, CCKAR, CCK
18	ondansetron⁵⁰ ⁴⁴ ²⁵ ¹²	12.7	HTR3A, CCKAR, CCK
19	tegaserod⁴⁴ ²⁹ ¹²	11.6	CCK, HTR3A
20	rimonabant⁴⁴ ²⁹ ¹²	11.6	CCK, GHRL
21	bismuth⁴⁴ ²⁵	10.5	CCKAR, HRH2
22	quetiapine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.5	ADRA2C, HTR3A, GHRL
23	thioperamide⁴⁴ ⁶⁰ ²⁹	11.5	HTR3A, HRH2
24	risperidone⁴⁴ ⁵⁰ ²⁹ ⁶⁰ ²⁵ ¹²	14.5	GHRL, HTR3A, ADRA2C
25	cocaine⁴⁴ ¹²	10.5	CCK, CCKAR, GHRL
26	olanzapine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.5	ADRA2C, HTR3A, GHRL
27	morphine⁴⁴ ⁵⁰ ²⁹ ¹²	12.5	CCK, CCKAR, TRPV1
28	clozapine⁴⁴ ²⁹ ⁵⁰ ¹²	12.4	ADRA2C, HTR3A, GHRL
29	pepsinogen⁴⁴	9.4	HRH2, CCK
30	carbohydrates⁴⁴	9.4	GHRL, CCKAR, CCK
31	pramlintide⁴⁴ ¹²	10.4	GHRL, CCK
32	omeprazole⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.3	HRH2, CCKAR, CCK
33	pirenzepine⁴⁴ ²⁹ ¹²	11.3	HRH2, GHRL, CCK
34	amide⁴⁴	9.3	CCK, CCKAR, GHRL, TRPV1
35	cisapride⁴⁴ ²⁹ ¹²	11.2	CCK, HTR3A, HRH2
36	opiate⁴⁴	9.2	HRH2, GHRL, CCK
37	metoclopramide⁴⁴ ⁵⁰ ¹²	11.2	CCK, HTR3A, HRH2
38	acetaminophen⁴⁴ ³ ⁵⁰ ²⁵ ¹²	13.2	HRH2, GHRL, CCK
39	norepinephrine⁴⁴ ²⁵ ¹²	11.1	GHRL, HTR3A, CCK, ADRA2C
40	atropine⁴⁴ ²⁹ ¹²	11.0	HRH2, GHRL, CCKAR, CCK
41	benzodiazepines⁴⁴	8.9	HRH2, HTR3A, CCKAR, CCK
42	5-hydroxytryptamine⁴⁴	8.8	CCK, HTR3A, GHRL, HRH2
43	gaba⁴⁴	8.8	CCK, CCKAR, HTR3A, GHRL, TRPV1
44	histamine⁴⁴ ²⁹ ²⁵	10.8	CCK, HTR3A, GHRL, HRH2
45	acetylcholine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	12.8	CCK, HTR3A, GHRL, HRH2
46	cholesterol⁴⁴ ²⁹ ²⁵ ¹²	11.5	HRH2, GHRL, CCKAR, CCK
47	tetrodotoxin⁴⁴ ⁶⁰ ²⁹	10.4	CCK, CCKAR, HTR3A, HRH2, TRPV1
48	adenylate⁴⁴	8.3	CCK, HTR3A, GHRL, HRH2, TRPV1
49	dopamine⁴⁴ ²⁹ ²⁵ ¹²	11.3	ADRA2C, CCK, CCKAR, HTR3A, GHRL, TRPV1
50	forskolin⁴⁴ ⁵⁰ ¹²	10.3	TRPV1, HRH2, GHRL, CCK, ADRA2C

GO Terms for genes affiliated with Dyspepsia

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Dyspepsia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	8.9	CCK, HTR3A, GHRL
2	plasma membrane	GO:005886	7.8	TRPV1, HRH2, HTR3A, CCKAR, ADRA2C
3	integral component of plasma membrane	GO:005887	7.7	TRPV1, HRH2, HTR3A, CCKAR, ADRA2C

Biological processes related to Dyspepsia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cytosolic calcium ion concentration	GO:007204	9.8	GHRL, CCKAR
2	digestion	GO:007586	9.7	HTR3A, CCKAR
3	regulation of sensory perception of pain	GO:051930	9.7	CCK, ADRA2C
4	axonogenesis	GO:007409	9.6	CCK, CCKAR
5	neuron migration	GO:001764	9.4	CCKAR, CCK
6	positive regulation of vasoconstriction	GO:045907	9.2	HRH2, ADRA2C

Products for genes affiliated with Dyspepsia

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Dyspepsia

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: DYS014 MIFTS: 53	Dyspepsia malady Gastrointestinal diseases category
8 genes, 13 tissues, 95 related diseases, clinical trials Download this MalaCard Expand all tables

Dyspepsia malady