Dyspepsia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DYS014 MIFTS: 50	Dyspepsia malady Categories: Gastrointestinal diseases
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Aliases & Classifications for Dyspepsia

Aliases & Descriptions for Dyspepsia:

Name: Dyspepsia ¹² ⁴² ¹⁴

Indigestion ¹² ⁴¹ ¹⁴

Dyspepsia, Indigestion Nos ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of oesophagus, stomach and duodenum

Dyspepsia

External Ids:

Disease Ontology ¹² DOID:2321

ICD10 ³³ K30 R10.13

MeSH ⁴² D004415

NCIt ⁴⁷ C26756

SNOMED-CT ⁶⁴ 139299007 155722007 162031009 more

UMLS ⁶⁹ C0013395

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Summaries for Dyspepsia

MedlinePlus : ⁴¹ nearly everyone has had indigestion at one time. it's a feeling of discomfort or a burning feeling in your upper abdomen. you may have heartburn or belch and feel bloated. you may also feel nauseated, or even throw up. you might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. sometimes the cause is a problem with the digestive tract, like an ulcer or gerd. avoiding foods and situations that seem to cause it may help. because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. you may need medicines to treat the symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Dyspepsia, also known as indigestion, is related to schizophrenia and opisthorchiasis. An important gene associated with Dyspepsia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Dopamine and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and brain, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : ⁷¹ Indigestion, also known as dyspepsia, is a condition of impaired digestion. Symptoms may include upper... more...

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Related Diseases for Dyspepsia

Diseases related to Dyspepsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)

id	Related Disease	Score	Top Affiliating Genes
1	schizophrenia	28.5	CCK CCKAR GNB3 HRH2 HTR1A HTR3A
2	opisthorchiasis	10.8
3	duodenitis	10.3
4	irritable bowel syndrome	10.3
5	ornithosis	10.2	CCK HTR3A SLC6A4
6	ischemic neuropathy	10.2	CCK GHRL HTR3A
7	cholesteatoma	10.2	CCK GHRL SLC6A4
8	nutritional optic neuropathy	10.2	GHRL SST
9	hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy	10.2	CCK GHRL SLC6A4
10	abnormal pupillary function	10.1	HTR1A HTR3A
11	gastroesophageal reflux	10.1
12	chagas disease	10.1	CCK GHRL HTR3A SLC6A4
13	simultanagnosia	10.1	CCK PTGS2 TRPV1
14	anodontia	10.1	HTR1A HTR3A SLC6A4
15	renpenning syndrome	10.1	HTR1A HTR3A SLC6A4
16	gemistocytic astrocytoma	10.1	CCK HRH2 SST
17	cervical carcinosarcoma	10.1	CCK PTGS2 TRPV1
18	gastroparesis	10.1
19	postencephalitic parkinson disease	10.1	HTR1A HTR3A SLC6A4
20	borderline leprosy	10.1	CCK CCKAR SST
21	deafness, autosomal recessive 20	10.1	CCK HTR3A SLC6A4 TRPV1
22	autism spectrum disorder	10.1	CCK GHRL SLC6A4 TRPV1
23	cushing's syndrome	10.1	CCK PTGS2
24	small intestinal l-cell glucagon-like peptide producing tumor	10.1	HRH2 PTGS1 PTGS2
25	primary non-gestational choriocarcinoma of ovary	10.1	CXCL8 PTGS2
26	dry eye syndrome	10.1	HTR1A SLC6A4
27	duodenal ulcer	10.1
28	cervicitis	10.0	CCK PTGS1 PTGS2
29	peroneal neuropathy	10.0	GHRL SST TRPV1
30	tinea pedis	10.0	CYP2C19 HTR1A SLC6A4
31	pagon stephan syndrome	10.0	PTGS1 PTGS2
32	sweat gland cancer	10.0	CCK HTR3A SLC6A4 SST
33	gastritis	10.0
34	body dysmorphic disorder	10.0	GHRL SST TRPV1
35	peptic ulcer disease	10.0
36	angioedema	10.0	HRH2 PTGS1 PTGS2
37	hepatitis d	10.0	CCK HTR1A HTR3A SLC6A4
38	lacrimal apparatus disease	10.0	CXCL8 CYP2C19 HRH2
39	retinoblastoma	10.0	HTR1A HTR3A SLC6A4
40	uterine ligament clear cell adenocarcinoma	10.0	CXCL8 GHRL TRPV1
41	ovarian mucinous neoplasm	10.0	CYP2C19 HRH2 PTGS2 TRPV1
42	mucositis	10.0
43	personality disorder	10.0	CCK HTR1A SLC6A4 TRPV1
44	neovascular glaucoma	10.0	CXCL8 PTGS2 TRPV1
45	myocardial stunning	10.0	CCK SST
46	chronic conjunctivitis	10.0	HTR1A HTR3A SLC6A4
47	hepatitis b reinfection following liver transplantation	9.9	HTR1A HTR3A SLC6A4 SST
48	lichen disease	9.9	CXCL8 HTR1A SLC6A4
49	h. pylori infection	9.9
50	preeclampsia/eclampsia 5	9.9	CCK GHRL HTR1A HTR3A SLC6A4

Graphical network of the top 20 diseases related to Dyspepsia:

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Symptoms & Phenotypes for Dyspepsia

GenomeRNAi Phenotypes related to Dyspepsia according to GeneCards Suite gene sharing:

²⁶

id	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00381-A-1	9.23	HRH2 HTR1A HTR3A SLC6A4
2	Decreased viability	GR00381-A-3	9.23	HRH2 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Dyspepsia:

⁴⁴

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.06	SST TRPV1 CCK CCKAR GHRL HRH2
2	endocrine/exocrine gland	MP:0005379	9.76	HTR3A PTGS1 PTGS2 SLC6A4 CCK CCKAR
3	digestive/alimentary	MP:0005381	9.73	CCKAR GHRL HRH2 PTGS1 PTGS2 SST
4	homeostasis/metabolism	MP:0005376	9.7	CCK CCKAR GHRL HRH2 HTR1A HTR3A
5	nervous system	MP:0003631	9.36	CCK CCKAR GNB3 HRH2 HTR1A HTR3A

Sources

Drugs & Therapeutics for Dyspepsia

Drugs for Dyspepsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 326)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dopamine

Approved

Phase 4,Phase 3,Phase 1

51-61-6, 62-31-7

681

Aspirin

Approved, Vet_approved

Phase 4,Phase 3

50-78-2

2244

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Pantoprazole

Approved

Phase 4,Phase 2,Phase 3

102625-70-7

4679

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

73590-58-6

4594

Celecoxib

Approved, Investigational

Phase 4,Phase 3

169590-42-5

2662

Tetracycline

Approved, Vet_approved

Phase 4

60-54-8

5353990

Histamine

Approved, Investigational

Phase 4,Phase 2,Phase 3

75614-87-8, 51-45-6

774

Ranitidine

Approved

Phase 4,Phase 2,Phase 3

66357-59-3, 66357-35-5

3001055

Famotidine

Approved

Phase 4,Phase 3

76824-35-6

3325

Mianserin

Approved

Phase 4

24219-97-4

4184

Naproxen

Approved, Vet_approved

Phase 4,Phase 3,Phase 1

22204-53-1

1302 156391

Amitriptyline

Approved

Phase 4,Phase 2,Phase 3

50-48-6

2160

Clarithromycin

Approved

Phase 4,Phase 3,Phase 2

81103-11-9

84029

Amoxicillin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

26787-78-0

33613 2171

Metronidazole

Approved

Phase 4,Phase 3

443-48-1

4173

Lubiprostone

Approved, Investigational

Phase 4

136790-76-6

656719

Mirtazapine

Approved

Phase 4

85650-52-8, 61337-67-5

4205

Lansoprazole

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

103577-45-3

3883

Esomeprazole

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

161796-78-7, 119141-88-7

4594 9579578

Cyclobenzaprine

Approved

Phase 4

303-53-7

2895

Aluminum hydroxide

Approved

Phase 4,Phase 3

21645-51-2

Mannitol

Approved, Investigational

Phase 4

69-65-8

453 6251

Erythromycin

Approved, Vet_approved

Phase 4

114-07-8

12560

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Ibuprofen

Approved

Phase 4,Phase 3

15687-27-1

3672

Azithromycin

Approved

Phase 4

83905-01-5

55185 53477736 447043

Ofloxacin

Approved

Phase 4,Phase 3

82419-36-1

4583

Rabeprazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

117976-89-3

5029

Tinidazole

Approved, Investigational

Phase 4,Phase 2,Phase 3

19387-91-8

5479

Levofloxacin

Approved, Investigational

Phase 4,Phase 3

100986-85-4

149096

Furazolidone

Approved, Vet_approved

Phase 4

67-45-8

3435 5323714

Guaifenesin

Approved, Vet_approved

Phase 4,Phase 3

93-14-1

3516

Magnesium Hydroxide

Approved

Phase 4

1309-42-8

Potassium Citrate

Approved, Vet_approved

Phase 4

Loperamide

Approved

Phase 4,Phase 2,Phase 3

53179-11-6

3955

Trimebutine

Approved

Phase 4

39133-31-8

Ursodeoxycholic acid

Approved, Investigational

Phase 4

128-13-2

31401

Ketorolac

Approved

Phase 4

74103-06-3, 66635-83-4

3826

Parecoxib

Approved

Phase 4

198470-84-7

leucovorin

Approved, Nutraceutical

Phase 4,Phase 3

58-05-9

54575, 6560146 143

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Ginseng

Approved, Nutraceutical

Phase 4

50647-08-0

decanoic acid

Experimental

Phase 4

334-48-5

2969

Maleic acid

Experimental

Phase 4

110-16-7

444266

Bismuth

Phase 4,Phase 2,Phase 3

7440-69-9

16682734 105143

Ranitidine bismuth citrate

Phase 4,Phase 2,Phase 3

Dexlansoprazole

Phase 4,Phase 3,Phase 1,Phase 2

138530-94-6, 103577-45-3

9578005

Histamine Phosphate

Phase 4,Phase 2,Phase 3

51-74-1

65513

Proton pump inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 308)

id	Name	Status	NCT ID	Phase
1	Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia	Unknown status	NCT00978159	Phase 4
2	Mirtazapine Versus Placebo in Functional Dyspepsia	Unknown status	NCT01240096	Phase 4
3	The Efficacy of Pantoprazole Treatment in Patients With Functional Dyspepsia	Unknown status	NCT01608750	Phase 4
4	The Efficacy and Safety Study of Rikkunshito in Patients With Functional Dyspepsia	Unknown status	NCT02037776	Phase 4
5	Clinical Study to Evaluate the Efficacy and the Safety of Eradication Therapy for Helicobacter Pylori in Functional Dyspepsia	Unknown status	NCT00990405	Phase 4
6	Gastric Functions & Proton Pump Inhibitor( PPI) Study	Unknown status	NCT00951431	Phase 4
7	Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice	Unknown status	NCT00363701	Phase 4
8	Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis	Unknown status	NCT02355236	Phase 4
9	Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy	Unknown status	NCT02105090	Phase 4
10	Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit	Unknown status	NCT00844831	Phase 4
11	Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice	Unknown status	NCT01273441	Phase 4
12	14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication	Unknown status	NCT01464060	Phase 4
13	Cyclobenzaprine Extended Release (ER) for Fibromyalgia	Unknown status	NCT01041495	Phase 4
14	Efficacy of Banhasasim-tang on Functional Dyspepsia	Completed	NCT00987805	Phase 4
15	Comparison of Pantoprazole and Ranitidine in Dyspepsia	Completed	NCT01737840	Phase 4
16	Compliance With Antidepressant Medication in Treatment of Functional Dyspepsia	Completed	NCT01851863	Phase 4
17	Lansoprazole Versus Mosapride for Functional Dyspepsia	Completed	NCT00663897	Phase 4
18	A Study to Demonstrate the Efficacy and Safety of Motilitone®	Completed	NCT01817465	Phase 4
19	The Efficacy and Safety of Qizhiweitong Granule on Patients With Functional Dyspepsia in a Multi-center Clinical Study	Completed	NCT02460601	Phase 4
20	A Comparison of Efficacy of Intravenous Esomeprazole and Ranitidine Treatment of Dyspeptic Pain	Completed	NCT02197143	Phase 4
21	High Dose PPI Triple Therapy Versus Sequential Therapy for Helicobacter Pylori Eradication	Completed	NCT01888237	Phase 4
22	Proton Pump Inhibitor Treatment Stop	Completed	NCT00120315	Phase 4
23	Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders	Completed	NCT02566876	Phase 4
24	Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication	Completed	NCT02175901	Phase 4
25	Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole	Completed	NCT01281501	Phase 4
26	Empirical Rescue Therapies of Helicobacter Pylori Infection	Completed	NCT01668927	Phase 4
27	Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment	Completed	NCT01667718	Phase 4
28	Amtolmetin Gaucil in Knee Osteoarthritis	Completed	NCT02865161	Phase 4
29	Aizthromycin or Clarithromycin in H-pylori Eradication Regimen	Completed	NCT01667692	Phase 4
30	Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori	Completed	NCT01667575	Phase 4
31	Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy	Completed	NCT02633930	Phase 4
32	Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy	Completed	NCT02296021	Phase 4
33	Ulcer Prevention Study in Post Gastric Bypass Patients	Completed	NCT00557349	Phase 4
34	Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection	Completed	NCT02835560	Phase 4
35	Glucomannan for the Treatment of Abdominal Pain-related Functional Gastrointestinal Disorders in Childhood	Completed	NCT01495806	Phase 4
36	Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion	Completed	NCT00843063	Phase 4
37	Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients	Completed	NCT00650455	Phase 4
38	Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole	Completed	NCT00640809	Phase 4
39	Randomized, Double Blind, Multicenter Study of the Safety and Efficacy of Valdecoxib 40 mg Once Daily Compared With Diclofenac 75 mg Twice Daily in Acute Low Back Pain	Completed	NCT00649610	Phase 4
40	Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia	Recruiting	NCT02134405	Phase 4
41	BRAVO Study for Functional Dyspepsia	Recruiting	NCT01349413	Phase 4
42	Effect of Short-term Motilitone Therapy on Health-related Quality of Life in PD Patients With Gastrointestinal Symptoms	Recruiting	NCT02775591	Phase 4
43	Mast Cells in Acid-induced Intestinal Permeability	Recruiting	NCT02664051	Phase 4
44	Prucalopride Versus Placebo in Gastroparesis	Recruiting	NCT02510976	Phase 4
45	Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment	Recruiting	NCT02988089	Phase 4
46	Heweizhixie capsuleTherapy on Patients With Diarrhea	Recruiting	NCT02607176	Phase 4
47	Helicobacter Eradication Aspirin Trial	Recruiting	NCT01506986	Phase 4
48	Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole	Recruiting	NCT02986685	Phase 4
49	Clinical Trial of Efficacy and Safety of Kolofort in Functional Dyspepsia Patients	Not yet recruiting	NCT03119766	Phase 4
50	Therapeutic Effect of Ursodeoxycholic Acid in Functional Dyspepsia	Not yet recruiting	NCT03004118	Phase 4

Search NIH Clinical Center for Dyspepsia

Cochrane evidence based reviews: dyspepsia

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Genetic Tests for Dyspepsia

Sources

Anatomical Context for Dyspepsia

MalaCards organs/tissues related to Dyspepsia:

³⁹

Testes, Kidney, Brain, Spleen, Heart, Tongue, Small Intestine

Sources

Publications for Dyspepsia

Articles related to Dyspepsia:

(show top 50) (show all 749)

id	Title	Authors	Year
1	Editorial: Moving Away From Focussing on Gastric Pathophysiology in Functional Dyspepsia: New Insights and Therapeutic Implications. ( 28050031 )	Talley N.J.	2017
2	The Role of Duodenal Inflammation in Functional Dyspepsia. ( 27811629 )	Walker M.M....Talley N.J.	2017
3	Pathophysiological Abnormalities in Functional Dyspepsia Subgroups According to the Rome III Criteria. ( 27958284 )	Vanheel H....Tack J.	2017
4	Celiac disease prevalence is not increased in patients with functional dyspepsia. ( 28079237 )	Lasa J....Zagalsky D.	2017
5	Minimal differences in prevalence and spectrum of organic disease at upper gastrointestinal endoscopy between selected secondary care patients with symptoms of gastro-oesophageal reflux or dyspepsia. ( 27973922 )	Irvine A.J....Ford A.C.	2017
6	Self-rated health and functional capacity in individuals reporting overlapping symptoms of gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome - a population based study. ( 28521729 )	JarbA...Haastrup P.F.	2017
7	Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia. ( 28052285 )	Mori H....Kanai T.	2017
8	Dyspepsia and constipation in patients with schizophrenia spectrum disorders. ( 27564411 )	Virtanen T....Suvisaari J.	2016
9	Helicobacter pylori and Its Virulence Factors' Effect on Serum Oxidative DNA Damages in Adults With Dyspepsia. ( 28033692 )	Shahi H....Reiisi S.	2016
10	Effect of acupuncture and its influence on cerebral activity in functional dyspepsia patients: study protocol for a randomized controlled trial. ( 27039086 )	Ko S.J....Lee J.H.	2016
11	Appetite-regulating gut peptides and functional dyspepsia. ( 27725457 )	Yakabi K....Hosomi E.	2016
12	The Intragastric Pressure Measurement: A Novel Method to Assess Gastric Accommodation in Functional Dyspepsia Children. ( 27557427 )	Carbone F....Hoffman I.	2016
13	Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia. ( 27013784 )	Tominaga K....Arakawa T.	2016
14	Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. ( 27444264 )	Koloski N.A....Talley N.J.	2016
15	A study of clinico-endoscopic profile of patient presenting with dyspepsia. ( 27727685 )	Desai S....Borgohain M.	2016
16	Influence of CYP2C19 on Helicobacter pylori eradication in Brazilian patients with functional dyspepsia. ( 27706745 )	Nabinger D.D....Simon D.	2016
17	Implementation and evaluation of early gastroscopy for patients with dyspepsia and warning signs in Primary Care. ( 28010892 )	GarcA-a-Alonso F.J....Bermejo F.	2016
18	Dyspepsia and the microbiome: time to focus on the small intestine. ( 27489239 )	Zhong L....Holtmann G.	2016
19	Individualized Acupuncture for Symptom Relief in Functional Dyspepsia: A Randomized Controlled Trial. ( 27732083 )	Ko S.J....Park J.W.	2016
20	Upregulation of Vanilloid Receptor-1 in Functional Dyspepsia With or Without Helicobacter pylori Infection. ( 27175641 )	Choi Y.J....Jung H.C.	2016
21	Functional dyspepsia: new insights into pathogenesis and therapy. ( 27048251 )	Talley N.J.	2016
22	The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients. ( 27840636 )	Meng W.P....LA1 M.H.	2016
23	Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia: Results of a Multicenter Survey Study. ( 27069497 )	Bae K.H....Lee S.	2016
24	Histopathological study of upper gastrointestinal endoscopic biopsy in patients with dysphagia and dyspepsia in south western coast of India. ( 27772904 )	Gopal S.M....Vaidya R.	2016
25	Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis. ( 27022230 )	Du L.J....Dai N.	2016
26	Nutritional habits in functional dyspepsia and its subgroups: a comparative study. ( 27124324 )	GAPktaA9 Z....Arslan S.	2016
27	Dietary fat intake and functional dyspepsia. ( 27195249 )	Khodarahmi M....Azadbakht L.	2016
28	Gastric Activity and Gut Peptides in Patients With Functional Dyspepsia: Postprandial Distress Syndrome Versus Epigastric Pain Syndrome. ( 27092429 )	Russo F....Martulli M.	2016
29	Gastric siderosis as a cause of dyspepsia. ( 27511759 )	Antunes A.G....Guerreiro H.	2016
30	The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia. ( 27644564 )	Shinozaki S....Yamamoto H.	2016
31	Development of a Symptom-Based Patient-Reported Outcome Instrument for Functional Dyspepsia: A Preliminary Conceptual Model and an Evaluation of the Adequacy of Existing Instruments. ( 27020447 )	Taylor F....Silberg D.G.	2016
32	Association of Psychological Characteristics and Functional Dyspepsia Treatment Outcome: A Case-Control Study. ( 27547220 )	Chen Y....Yu R.	2016
33	Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups. ( 27160990 )	Takeshita E....Fujimoto K.	2016
34	Sleep disturbance due to heartburn and regurgitation is common in patients with functional dyspepsia. ( 27087946 )	Vakil N....Dent J.	2016
35	Evaluating community pharmacists` dyspepsia knowledge: A cross-sectional study in Tehran, Iran. ( 27594437 )	Abbasinazari M....Arezoo A.	2016
36	The C825T Polymorphism of the G-Protein I^3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis. ( 27057160 )	Song Y.Z....Huang Q.K.	2016
37	Pattern of psychotropic medications use in a cohort of patients with uninvestigated dyspepsia undergoing upper endoscopy: A retrospective study. ( 27858904 )	Dore M.P....Pes G.M.	2016
38	Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection. ( 27448107 )	Maity A....Pradhan M.	2016
39	Gastric microbiota in the functional dyspepsia patients treated with probiotic yogurt. ( 27752337 )	Nakae H....Koga Y.	2016
40	Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study. ( 27503912 )	Heidari Z....Adibi P.	2016
41	Helicobacter pylori eradication effect on patients with functional dyspepsia symptoms. ( 27091036 )	Jodaki A....Hemati K.	2016
42	Factors associated with the occurrence ofA functional dyspepsia and insomnia inA shift-working nurses. ( 27061691 )	Jung H.S....Lee B.	2016
43	Functional Dyspepsia: An Enigma in a Conundrum. ( 27437927 )	Romano C....Benninga M.A.	2016
44	Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis. ( 27028618 )	Zhou W....Zhang H.	2016
45	Effect of Shuwei Decoction () on rats with functional dyspepsia. ( 27392478 )	Wang X.J....Zhang L.M.	2016
46	Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. ( 27478434 )	Takagi A....Koga Y.	2016
47	Self-medication of irritable bowel syndrome and dyspepsia: How appropriate is it? ( 27162806 )	Niknam R....Mahmoudi P.	2016
48	Validation of the Leuven Postprandial Distress Scale, a questionnaire for symptom assessment in the functional dyspepsia/postprandial distress syndrome. ( 27518319 )	Carbone F....Tack J.	2016
49	Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia. ( 27457769 )	Friesen C.A....Schurman J.V.	2016
50	Functional dyspepsia. ( 27540688 )	Talley N.J....Holtmann G.	2016

Sources

Genes for Dyspepsia

Genes related to Dyspepsia (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	38.19	DISEASES inferred ¹⁴ ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	GHRL	Ghrelin And Obestatin Prepropeptide	34.22	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
3	CCK	Cholecystokinin	33.9	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
4	HTR3A	5-Hydroxytryptamine Receptor 3A	33.58	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
5	HRH2	Histamine Receptor H2	33.57	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
6	GNB3	G Protein Subunit Beta 3	33.12	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
7	PTGS2	Prostaglandin-Endoperoxide Synthase 2	33.1	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
8	CCKAR	Cholecystokinin A Receptor	32.94	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
9	SLC6A4	Solute Carrier Family 6 Member 4	32.88	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
10	SST	Somatostatin	32.36	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
11	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	31.99	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
12	PTGS1	Prostaglandin-Endoperoxide Synthase 1	31.54	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
13	CXCL8	C-X-C Motif Chemokine Ligand 8	31.47	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
14	HTR1A	5-Hydroxytryptamine Receptor 1A	22.01	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	PGC	Progastricsin	21.54	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)

Sources

Variations for Dyspepsia

Sources

Expression for Dyspepsia

Search GEO for disease gene expression data for Dyspepsia.

Sources

Pathways for Dyspepsia

Pathways related to Dyspepsia according to GeneCards Suite gene sharing:

(show all 13)

id	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶² Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶² Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶² Formyl peptide receptors bind formyl peptides and many other ligands ⁶² G alpha (i) signalling events ⁶² GPCR ligand binding ⁶² GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁷ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶² Peptide GPCRs ¹ Relaxin receptors ⁶² Tachykinin receptors bind tachykinins ⁶² Vasopressin-like receptors ⁶²	13.18	CCK CCKAR CXCL8 GHRL GNB3 HRH2
2	Neuroscience ⁴	12.24	GNB3 HTR1A PTGS1 PTGS2
3	Taste transduction ³⁷ Show member pathways Class C/3 (Metabotropic glutamate/pheromone receptors) ⁶²	11.74	GNB3 HTR1A HTR3A
4	Linoleic acid metabolism ³⁷ Show member pathways alpha-Linolenic acid metabolism ³⁷ Arachidonic acid metabolism ³⁷	11.7	CYP2C19 PTGS1 PTGS2
5	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.65	CXCL8 GNB3 HTR1A HTR3A SLC6A4 SST
6	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁵⁸	11.25	CYP2C19 GNB3 PTGS1
7	Serotonergic synapse ³⁷	11.22	CYP2C19 GNB3 HTR1A HTR3A PTGS1 PTGS2
8	HETE and HPETE biosynthesis and metabolism ²¹ Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶²	10.96	PTGS1 PTGS2
9	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁵⁸	10.94	HTR1A HTR3A SLC6A4
10	Eicosanoid Synthesis ¹	10.89	PTGS1 PTGS2
11	Prostaglandin 2 biosynthesis and metabolism FM ²¹	10.86	PTGS1 PTGS2
12	Overview of nanoparticle effects ¹	10.61	CXCL8 PTGS1 PTGS2
13	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁵⁸	10.58	PTGS1 PTGS2

Sources

GO Terms for Dyspepsia

Cellular components related to Dyspepsia according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:0043025	9.46	CCK HTR3A SST TRPV1
2	neuron projection	GO:0043005	9.26	GNB3 PTGS2 SLC6A4 TRPV1
3	organelle membrane	GO:0031090	8.8	CYP2C19 PTGS1 PTGS2

Biological processes related to Dyspepsia according to GeneCards Suite gene sharing:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.86	CXCL8 PTGS1 PTGS2 TRPV1
2	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.74	CCKAR GHRL TRPV1
3	response to nutrient	GO:0007584	9.65	CCKAR SLC6A4 SST
4	excitatory postsynaptic potential	GO:0060079	9.63	GHRL HTR3A TRPV1
5	decidualization	GO:0046697	9.58	GHRL PTGS2
6	regulation of blood pressure	GO:0008217	9.58	GNB3 PTGS1 PTGS2
7	prostaglandin metabolic process	GO:0006693	9.55	PTGS1 PTGS2
8	vasoconstriction	GO:0042310	9.54	HTR1A SLC6A4
9	digestion	GO:0007586	9.54	CCKAR PGC SST
10	prostaglandin biosynthetic process	GO:0001516	9.52	PTGS1 PTGS2
11	cellular response to ATP	GO:0071318	9.51	PTGS2 TRPV1
12	memory	GO:0007613	9.5	HRH2 PTGS2 SLC6A4
13	G-protein coupled receptor signaling pathway	GO:0007186	9.5	CCKAR CXCL8 GHRL GNB3 HRH2 HTR1A
14	cyclooxygenase pathway	GO:0019371	9.49	PTGS1 PTGS2
15	serotonin receptor signaling pathway	GO:0007210	9.43	HTR1A HTR3A
16	response to organonitrogen compound	GO:0010243	9.33	PTGS2 SST TRPV1
17	regulation of hormone secretion	GO:0046883	9.26	CCKAR HTR1A
18	negative regulation of synaptic transmission, dopaminergic	GO:0032227	8.62	PTGS2 SLC6A4

Molecular functions related to Dyspepsia according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transducer activity	GO:0004871	9.62	CCKAR GNB3 HRH2 HTR1A
2	heme binding	GO:0020037	9.43	CYP2C19 PTGS1 PTGS2
3	hormone activity	GO:0005179	9.33	CCK GHRL SST
4	serotonin binding	GO:0051378	8.96	HTR1A HTR3A
5	prostaglandin-endoperoxide synthase activity	GO:0004666	8.62	PTGS1 PTGS2

Sources

Sources for Dyspepsia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ ExPASy

¹⁷ FDA Approved Drugs

¹⁸ FMA

¹⁹ GeneAnalytics

²⁰ GeneCards

²¹ GeneGo (Thomson Reuters)

²² GeneHancer via GeneCards

²³ GeneReviews

²⁴ GeneTests

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MeSH

⁴³ MESH via Orphanet

⁴⁴ MGI

⁴⁵ NCBI Bookshelf

⁴⁶ NCI

⁴⁷ NCIt

⁴⁸ NDF-RT

⁴⁹ NIH Clinical Center

⁵⁰ NIH Rare Diseases

⁵¹ NINDS

⁵² Novoseek

⁵³ Novus Biologicals

⁵⁴ OMIM

⁵⁵ OMIM via Orphanet

⁵⁶ Orphanet

⁵⁷ PathCards

⁵⁸ PharmGKB

⁵⁹ PubMed

⁶⁰ QIAGEN

⁶¹ R&D Systems

⁶² Reactome

⁶³ Sino Biological

⁶⁴ SNOMED-CT

⁶⁵ SNOMED-CT via Orphanet

⁶⁶ UniProtKB/Swiss-Prot

⁶⁷ TGDB

⁶⁸ Tocris

⁶⁹ UMLS

⁷⁰ UMLS via Orphanet

⁷¹ Wikipedia

Dyspepsia malady

Aliases & Classifications for Dyspepsia

Aliases & Descriptions for Dyspepsia:

Classifications:

External Ids:

Summaries for Dyspepsia

Related Diseases for Dyspepsia

Diseases related to Dyspepsia via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Dyspepsia:

Symptoms & Phenotypes for Dyspepsia

GenomeRNAi Phenotypes related to Dyspepsia according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Dyspepsia:

Drugs & Therapeutics for Dyspepsia

Drugs for Dyspepsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: dyspepsia

Genetic Tests for Dyspepsia

Anatomical Context for Dyspepsia

MalaCards organs/tissues related to Dyspepsia:

Publications for Dyspepsia

Articles related to Dyspepsia:

Genes for Dyspepsia

Genes related to Dyspepsia (0 elite genes):

Variations for Dyspepsia

Expression for Dyspepsia

Pathways for Dyspepsia

Pathways related to Dyspepsia according to GeneCards Suite gene sharing:

GO Terms for Dyspepsia

Cellular components related to Dyspepsia according to GeneCards Suite gene sharing:

Biological processes related to Dyspepsia according to GeneCards Suite gene sharing:

Molecular functions related to Dyspepsia according to GeneCards Suite gene sharing:

Sources for Dyspepsia