MCID: DYS073
MIFTS: 28

Dysphagia malady

Summaries for Dysphagia

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Having trouble swallowing (dysphagia) is a symptom that accompanies a number of neurological disorders. The problem can occur at any stage of the normal swallowing process as food and liquid move from the mouth, down the back of the throat, through the esophagus and into the stomach. Difficulties can range from a total inability to swallow, to coughing or choking because the food or liquid is entering the windpipe, which is referred to as aspiration. When aspiration is frequent a person can be at risk of developing pneumonia. Food may get "stuck" in the throat or individuals may drool because they cannot swallow their saliva. Neurological conditions that can cause swallowing difficulties are: stroke (the most common cause of dysphagia); traumatic brain injury; cerebral palsy; Parkinson disease and other degenerative neurological disorders such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), multiple sclerosis, progressive supranuclear palsy, Huntington disease, and myasthenia gravis. Muscular dystrophy and myotonic dystrophy are accompanied by dysphagia, which is also the cardinal symptom of oculopharyngeal muscular dystrophy, a rare, progressive genetic disorder.

MalaCards: Dysphagia, also known as deglutition disorders, is related to muscular dystrophy and oculopharyngeal muscular dystrophy. An important gene associated with Dysphagia is MEGF10 (multiple EGF-like-domains 10). The compounds gold and glutamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype behavior/neurological.

Wikipedia:63 Dysphagia is the medical term for the symptom of difficulty in swallowing. Although classified under... more...

Aliases & Classifications for Dysphagia

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Sources:
43NINDS, 44Novoseek, 60UMLS, 25ICD10
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Related Diseases for Dysphagia

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17GeneCards, 18GeneDecks
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Diseases related to Dysphagia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 339)
idRelated DiseaseScoreTop Affiliating Genes
1muscular dystrophy30.5GAA, PIK3C2A, PABPN1
2oculopharyngeal muscular dystrophy30.4PABPN1, GAA
3myopathy30.1GAA, PIK3C2A, SIL1, PABPN1
4ophthalmoplegia30.0MYH3
5myotonic dystrophy30.0GAA, PIK3C2A
6dementia30.0CP, TIMM8A, PIK3C2A
7neuropathy29.9PIK3C2A, PABPN1
8spinocerebellar ataxia type 329.6ATXN3
9huntington's disease29.6ATXN3, ATXN1, CP
10esophagitis10.7
11cervicitis10.6
12hyperostosis10.5
13diffuse idiopathic skeletal hyperostosis10.5
14pneumonia10.4
15inclusion body myositis10.3
16aspiration pneumonia10.3
17myositis10.3
18parkinson's disease10.3
19pharyngitis10.3
20esophageal cancer10.3
21eosinophilic esophagitis10.2
22aortic aneurysm10.2
23esophageal tuberculosis10.2
24thoracic aortic aneurysm10.2
25mediastinitis10.2
26tuberculosis10.2
27odontoma dysphagia syndrome10.2
28cerebritis10.1
29spondylosis10.1
30amyotrophic lateral sclerosis10.1
31plummer vinson syndrome10.1
32stroke, ischemic10.1
33lateral sclerosis10.1
34cerebral palsy10.1
35esophageal disease10.1
36multiple sclerosis10.1
37swallowing disorders10.1
38dysphagia lusoria10.1
39achalasia10.0
40duchenne muscular dystrophy10.0
41neuromuscular disease10.0
42thyroiditis10.0
43myopathy, early-onset, areflexia, respiratory distress, and dysphagia10.0
44myotonia congenita, atypical, acetazolamide-responsive10.0
45burns10.0
46subclavian artery aneurysm10.0
47foodborne botulism10.0
48lateral medullary syndrome10.0
49mutism10.0
50gastroparesis10.0

Graphical network of the top 20 diseases related to Dysphagia:



Diseases related to dysphagia

Clinical Features for Dysphagia

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Drugs & Therapeutics for Dysphagia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dysphagia

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Anatomical Context for Dysphagia

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32MalaCards
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MalaCards organs/tissues related to Dysphagia:

32
Brain

Animal Models for Dysphagia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dysphagia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4CP, SALL1, GAA, ATXN3, ATXN1, IL5

Publications for Dysphagia

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Genetic Variations for Dysphagia

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Expression for genes affiliated with Dysphagia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysphagia

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Pathways for genes affiliated with Dysphagia

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Compounds for genes affiliated with Dysphagia

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Dysphagia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gold449.6PRTN3, PIK3C2A, GAA
2glutamine449.6CP, ATXN3, ATXN1, IL5, PABPN1
3sodium nitroprusside449.4PIK3C2A, IL5, CP
4testosterone44 59 11 2412.3CP, PIK3C2A, ATXN3, ATXN1, IL5
5arginine449.2CP, IL5, PABPN1, PIK3C2A, GAA, SALL1

GO Terms for genes affiliated with Dysphagia

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16Gene Ontology
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Cellular components related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear inclusion bodyGO:04240510.2ATXN1, ATXN3

Biological processes related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to heatGO:03460510.2SLC52A3, ATXN3
2small molecule metabolic processGO:0442818.7AAAS, SLC52A3, SLC19A3, NUP62, PIK3C2A, NDUFA12

Products for genes affiliated with Dysphagia

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  • Antibodies
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  • Lysates
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Sources for Dysphagia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet