MCID: DYS073
MIFTS: 51

Dysphagia malady

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Summaries for Dysphagia

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Having trouble swallowing (dysphagia) is a symptom that accompanies a number of neurological disorders. The problem can occur at any stage of the normal swallowing process as food and liquid move from the mouth, down the back of the throat, through the esophagus and into the stomach. Difficulties can range from a total inability to swallow, to coughing or choking because the food or liquid is entering the windpipe, which is referred to as aspiration. When aspiration is frequent a person can be at risk of developing pneumonia. Food may get "stuck" in the throat or individuals may drool because they cannot swallow their saliva. Neurological conditions that can cause swallowing difficulties are: stroke (the most common cause of dysphagia); traumatic brain injury; cerebral palsy; Parkinson disease and other degenerative neurological disorders such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), multiple sclerosis, progressive supranuclear palsy, Huntington disease, and myasthenia gravis. Muscular dystrophy and myotonic dystrophy are accompanied by dysphagia, which is also the cardinal symptom of oculopharyngeal muscular dystrophy, a rare, progressive genetic disorder.

MalaCards: Dysphagia, also known as deglutition disorders, is related to muscular dystrophy and oculopharyngeal muscular dystrophy. An important gene associated with Dysphagia is MEGF10 (multiple EGF-like-domains 10), and among its related pathways is Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds ferrous ammonium sulfate and ferrozine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and thyroid, and related mouse phenotypes are muscle and nervous system.

Wikipedia:65 Dysphagia is the medical term for the symptom of difficulty in swallowing. Although classified under... more...

Aliases & Classifications for Dysphagia

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44NINDS, 45Novoseek, 62UMLS, 25ICD10
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Related Diseases for Dysphagia

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17GeneCards, 18GeneDecks
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Diseases related to Dysphagia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 427)
idRelated DiseaseScoreTop Affiliating Genes
1muscular dystrophy30.8PIK3C2A, PABPN1, GAA
2oculopharyngeal muscular dystrophy30.7PABPN1
3pericardial effusion30.2PIK3C2A
4myopathy30.1PIK3C2A, PABPN1, RPS27A, SIL1, GAA
5neuropathy30.1ALB, PABPN1, PIK3C2A
6dementia30.1PIK3C2A, TIMM8A, CP, RPS27A
7multiple system atrophy30.0ATXN1, ATXN3, RPS27A
8polymyositis30.0PIK3C2A, RPS27A, GAA
9spinocerebellar ataxia type 329.9ATXN3
10eosinophilic gastroenteritis29.9IL5
11huntington's disease29.8ATXN1, ATXN3
12spinocerebellar ataxia29.8RPS27A, ATXN3, ATXN1
13eosinophilia29.8IL5, PRTN3, PIK3C2A
14hypereosinophilic syndrome29.7IL5, KIT
15protein-energy malnutrition29.7TF, ALB
16galactosemia29.6TF, F3, ALB
17dysphagia lusoria10.8
18esophagitis10.7
19cervicitis10.7
20hyperostosis10.6
21diffuse idiopathic skeletal hyperostosis10.5
22pneumonia10.4
23inclusion body myositis10.4
24aspiration pneumonia10.4
25myositis10.4
26aneurysm10.4
27parkinson's disease10.3
28pharyngitis10.3
29plummer vinson syndrome10.3
30esophageal cancer10.3
31esophageal tuberculosis10.3
32eosinophilic esophagitis10.3
33thoracic aortic aneurysm10.3
34aortic aneurysm10.3
35mediastinitis10.3
36odontoma dysphagia syndrome10.3
37tuberculosis10.2
38swallowing disorders10.2
39bronchogenic cyst10.2
40spondylosis10.2
41amyotrophic lateral sclerosis10.2
42lateral sclerosis10.1
43cerebritis10.1
44multiple sclerosis10.1
45right aortic arch10.1
46baller-gerold syndrome10.1SALL1
47scleritis10.1PRTN3
48legionnaires' disease10.1PIK3C2A
49capillary leak syndrome10.1C1S
50status asthmaticus10.1PIK3C2A

Graphical network of the top 20 diseases related to Dysphagia:



Diseases related to dysphagia

Symptoms for Dysphagia

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Drugs & Therapeutics for Dysphagia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Dysphagia

Genetic Tests for Dysphagia

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Anatomical Context for Dysphagia

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33MalaCards
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MalaCards organs/tissues related to Dysphagia:

33
Brain, Testes, Thyroid, Tongue, Colon, Heart, Cortex, Lung, Eye, Skeletal muscle, Bone, Spinal cord, B cells, Prostate, Thymus

Animal Models for Dysphagia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dysphagia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8ATXN1, F3, MID1, ALB, KIT, GAA
2MP:00036317.6SALL1, CP, ATXN3, ATXN1, F3, MEGF10
3MP:00053867.3GAA, ATXN1, ATXN3, CP, SALL1, F3
4MP:00053786.6SALL1, ATXN1, PIK3C2A, TF, F3, MID1
5MP:00107686.5PIK3C2A, ATXN1, SALL1, F3, MID1, ALB
6MP:00053766.3CP, ATXN1, PIK3C2A, TF, F3, AAAS

Publications for Dysphagia

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52PubMed
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Articles related to Dysphagia:

(show top 50)    (show all 817)
idTitleAuthorsYear
1
Managing eating and drinking difficulties (dysphagia) with children who have learning disabilities: What is effective? (24414040)
2014
2
Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). (23747002)
2013
3
Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients. (23157278)
2013
4
Causes of dysphagia among different age groups: a systematic review of the literature. (24262954)
2013
5
Neuromuscular electrical stimulation efficacy in acute stroke feeding tube-dependent dysphagia during inpatient rehabilitation. (23478451)
2013
6
Slow esophageal propagation velocity: association with dysphagia for solids. (23181386)
2013
7
Severe Dysphagia after inferior alveolar nerve block preceded by cervical botolinum toxin injection: a case report. (24396583)
2013
8
Dysphagia lusoria in an infant. (23415621)
2013
9
Calcific retropharyngeal tendinitis of the longus colli muscle. Answer to the e-quid "Acute cervical pain and dysphagia in a 43A year-old man". (23357277)
2013
10
Functional Magnetic Stimulation Using a Parabolic Coil for Dysphagia After Stroke. (24320695)
2013
11
Dysphagia in a patient with recurrent small-cell lung cancer. (23159301)
2013
12
Dysphagia lusoria: Report of a series of six cases. (23623447)
2013
13
Delayed dysphagia from a foreign body granuloma mimicking a subepithelial neoplasm. (23103909)
2013
14
Author reply to "Oropharyngeal dysphagia in Parkinson's disease: comments on paper by Kalf et al." by Boot & Chaudhuri. (22902809)
2013
15
Incidence and risk factors for dysphagia after anterior cervical fusion. (23873236)
2013
16
Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia. (22722616)
2013
17
Dysphagia Following Posterior Fossa Surgery in Adults. (23318935)
2013
18
Impaired postoperative EGJ relaxation as a determinant of post laparoscopic fundoplication dysphagia: a study with high-resolution manometry before and after surgery. (22717797)
2012
19
Multiple cervical levels: increased risk of dysphagia and dysphonia during anterior cervical discectomy. (22828154)
2012
20
Effects of transcranial direct current stimulation (tDCS) on post-stroke dysphagia. (22572022)
2012
21
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
22
Dysphagia caused by garlic induced esophagitis. (23062683)
2012
23
Intraductal papillary mucinous neoplasm of the oesophagus: an unusual case of dysphagia. (22391370)
2012
24
Dysphagia due to adenoid cystic carcinoma of the base of the tongue. (22737963)
2012
25
Screening and clinical assessment of oropharyngeal dysphagia. (23052000)
2012
26
An uncommon cause of Dysphagia. (22237721)
2012
27
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
28
Treatment of language, motor speech impairments, and Dysphagia. (22810863)
2011
29
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
30
Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction. (19828479)
2010
31
Dysphagia due to tardive dyskinesia. (22174539)
2010
32
A modified approach to laparoscopic antireflux surgery may decrease postoperative dysphagia and gas bloat syndrome. (20551800)
2010
33
Kommerell diverticulum, right-sided aorta, and left aberrant subclavian artery in a patient with dysphagia. (19660293)
2010
34
Dysphagia lusoria. (19667034)
2009
35
Mature cystic teratoma: Unusual presentation as dysphagia. (20108063)
2009
36
Detecting dysphagia in inclusion body myositis. (19603245)
2009
37
Eosinophilic esophagitis : a cause of dysphagia]. (18214405)
2008
38
Dysphagia due to triple A syndrome: successful treatment of achalasia by balloon dilatation. (17853339)
2007
39
Cerebrospinal fluid leak after anterior cervical disc fusion: an unusual cause of dysphagia and neck mass. (17721401)
2007
40
Severe and prolonged dysphagia complicating botulinum toxin A injections for dystonia in Machado-Joseph disease. (8618703)
1996
41
Chronic posttraumatic thoracic aortic aneurysm presenting with dysphagia. (7674415)
1995
42
A note on the historical aspects of dysphagia lusoria. (1642389)
1992
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Dysphagia due to simultaneous laryngocele and Zenker's diverticulum. (3917519)
1985
45
Mitral valve disease and dysphagia. (6241564)
1984
46
Dysphagia lusoria: case report in a Nigerian girl. (7117182)
1982
47
Dysphagia lusoria: anomalous origin of the right subclavian artery. Demonstration by computed tomography. (7341258)
1981
48
Oropharyngeal dysphagia in patients with oculopharyngeal muscular dystrophy. (679079)
1978
49
Dysphagia lusoria. (13481400)
1957
50
Dysphagia lusoria: an unusual case. (14952469)
1952

Variations for Dysphagia

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Expression for genes affiliated with Dysphagia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysphagia

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Pathways for genes affiliated with Dysphagia

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50PathCards, 55Reactome
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Compounds for genes affiliated with Dysphagia

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45Novoseek, 11DrugBank, 24HMDB, 3BitterDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Dysphagia according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate4510.0CP, TF
2ferrozine4510.0CP, TF
3protamine459.8RPS27A, F3, CP
4apotransferrin459.8CP, TF
5dextran 70459.8ALB, F3
63,4-dichloroisocoumarin45 1110.7C1S, PRTN3, F3
7hepaplastin459.7ALB, F3
8kp-1019459.7TF, ALB
9ovomucoid459.7IL5, TF
10dextran sulfate459.5F3, IL5, ALB
11kininogen459.5ALB, F3, C1S
12suprofen45 1110.5TF, CP, ALB
13bismuth45 2410.4ALB, TF
14dtpa459.4TF, CP, ALB
15chloroquine45 3 51 29 1113.4GAA, KIT, RPS27A, TF
16vitamin b12459.3TF, CP, ALB
17carbohydrates459.1GAA, RPS27A, F3, CP, TF
18indomethacin45 29 61 1112.1CP, IL5, RPS27A, ALB
19ivig459.0ALB, IL5, PIK3C2A
20gelfoam459.0ALB, TF
21polysaccharide459.0GAA, RPS27A, F3, TF
22warfarin45 51 24 1111.9PIK3C2A, F3, ALB
23sodium nitroprusside458.9TF, PIK3C2A, CP, IL5
24cycloheximide458.9PRTN3, F3, IL5, RPS27A, KIT
25prostacyclin458.8TF, PIK3C2A, C1S, F3
26gold458.8GAA, KIT, PRTN3, PIK3C2A
27homocysteine45 249.8PIK3C2A, CP, F3, ALB
28tacrolimus45 51 1110.7TF, F3, IL5, RPS27A, ALB
29imatinib45 51 1110.7PRTN3, IL5, RPS27A, ALB, KIT
30uric acid45 249.6PIK3C2A, CP, ALB
31prednisolone45 29 1110.6TF, PIK3C2A, IL5, ALB
32bicarbonate458.6TF, PIK3C2A, ALB
33retinoic acid45 249.6CP, PRTN3, F3, IL5, RPS27A, KIT
34epinephrine45 24 1110.6TF, PIK3C2A, CP, F3, RPS27A
35glutamine458.5KIT, TF, ATXN1, ATXN3, CP, PABPN1
36ascorbic acid45 249.4TF, PIK3C2A, CP, ALB
37thyroxine45 249.4TF, PIK3C2A, CP, IL5, ALB
38cysteine458.3ATXN3, CP, F3, IL5, RPS27A, ALB
39citrate458.3TF, PIK3C2A, CP, F3, ALB
40serine458.2C1S, CP, PRTN3, F3, IL5, RPS27A
41arginine458.2PIK3C2A, C1S, CP, PABPN1, SALL1, IL5
42heparin45 29 24 1111.2PIK3C2A, C1S, CP, F3, IL5, ALB
43fibrinogen458.0TF, PIK3C2A, C1S, CP, F3, ALB
44methotrexate51 45 1110.0TF, PIK3C2A, IL5, ALB, KIT, GAA
45vegf457.9TF, PIK3C2A, CP, F3, IL5, RPS27A
46testosterone45 61 24 1110.8PIK3C2A, ATXN1, ATXN3, CP, IL5, RPS27A
47lactate457.7TF, PIK3C2A, CP, RPS27A, ALB, KIT
48aspartate457.6TF, PIK3C2A, CP, F3, RPS27A, ALB
49creatinine457.5TF, PIK3C2A, CP, PABPN1, F3, RPS27A
50alanine457.2TF, PIK3C2A, CP, PABPN1, PRTN3, F3

GO Terms for genes affiliated with Dysphagia

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16Gene Ontology
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Cellular components related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.7ALB, CP, C1S, TF
2extracellular spaceGO:0056158.0KIT, ALB, IL5, F3, CP, TF
3extracellular vesicular exosomeGO:0700626.8TF, PIK3C2A, CP, PRTN3, RPS27A, ALB

Biological processes related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of JAK-STAT cascadeGO:0464279.8KIT, IL5
2cytokine-mediated signaling pathwayGO:0192219.2KIT, RPS27A, IL5, AAAS
3negative regulation of programmed cell deathGO:0430699.1KIT, ALB
4transmembrane transportGO:0550858.4TF, CP, AAAS, RPS27A, ALB

Molecular functions related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3MID1, ATXN3, TF

Products for genes affiliated with Dysphagia

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Sources for Dysphagia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet