MCID: DYS073
MIFTS: 52

Dysphagia malady

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Summaries for Dysphagia

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NINDS:43 Having trouble swallowing (dysphagia) is a symptom that accompanies a number of neurological disorders. The problem can occur at any stage of the normal swallowing process as food and liquid move from the mouth, down the back of the throat, through the esophagus and into the stomach. Difficulties can range from a total inability to swallow, to coughing or choking because the food or liquid is entering the windpipe, which is referred to as aspiration. When aspiration is frequent a person can be at risk of developing pneumonia. Food may get "stuck" in the throat or individuals may drool because they cannot swallow their saliva. Neurological conditions that can cause swallowing difficulties are: stroke (the most common cause of dysphagia); traumatic brain injury; cerebral palsy; Parkinson disease and other degenerative neurological disorders such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), multiple sclerosis, progressive supranuclear palsy, Huntington disease, and myasthenia gravis. Muscular dystrophy and myotonic dystrophy are accompanied by dysphagia, which is also the cardinal symptom of oculopharyngeal muscular dystrophy, a rare, progressive genetic disorder.

MalaCards based summary: Dysphagia, also known as deglutition disorders, is related to oculopharyngeal muscular dystrophy and muscular dystrophy. An important gene associated with Dysphagia is MEGF10 (multiple EGF-like-domains 10), and among its related pathways is Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds ferrozine and ferrous ammonium sulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tongue, and related mouse phenotypes are muscle and nervous system.

Wikipedia:65 Dysphagia is the medical term for the symptom of difficulty in swallowing. Although classified under... more...

Aliases & Classifications for Dysphagia

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Sources:
43NINDS, 44Novoseek, 62UMLS, 25ICD10
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Dysphagia, Aliases & Descriptions:

Name: Dysphagia 43 44
 
Deglutition Disorders 62


Classifications:



External Ids:

ICD1025 R13

Related Diseases for Dysphagia

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Diseases related to Dysphagia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 434)
idRelated DiseaseScoreTop Affiliating Genes
1oculopharyngeal muscular dystrophy31.3PABPN1
2muscular dystrophy31.2PIK3C2A, PABPN1, GAA
3pericardial effusion30.8PIK3C2A
4machado-joseph disease30.8ATXN3
5eosinophilic gastroenteritis30.5IL5
6huntington's disease30.4ATXN1, ATXN3
7dementia30.4PIK3C2A, TIMM8A, CP, RPS27A
8multiple system atrophy30.4ATXN1, ATXN3, RPS27A
9neuropathy30.4ALB, PABPN1, PIK3C2A
10polymyositis30.3PIK3C2A, RPS27A, GAA
11myopathy30.3PIK3C2A, PABPN1, RPS27A, SIL1, GAA
12spinocerebellar ataxia30.2RPS27A, ATXN3, ATXN1
13eosinophilia30.1IL5, PRTN3, PIK3C2A
14hypereosinophilic syndrome30.0IL5, KIT
15protein-energy malnutrition29.8TF, ALB
16galactosemia29.5TF, F3, ALB
17dysphagia lusoria10.8
18esophagitis10.7
19cervicitis10.7
20hyperostosis10.6
21diffuse idiopathic skeletal hyperostosis10.6
22baller-gerold syndrome10.5SALL1
23scleritis10.5PRTN3
24legionnaires' disease10.5PIK3C2A
25capillary leak syndrome10.5C1S
26status asthmaticus10.5PIK3C2A
27neuronal intranuclear inclusion disease10.5RPS27A
28imperforate anus10.5SALL1
29kimura disease10.5IL5
30aceruloplasminemia10.5CP
31dentatorubral-pallidoluysian atrophy10.5ATXN1, ATXN3
32strongyloidiasis10.5IL5
33hereditary ataxia10.5ATXN1, ATXN3
34olivopontocerebellar atrophy10.5ATXN1, ATXN3
35spinocerebellar ataxia type 1210.5ATXN1, ATXN3
36spinocerebellar ataxia type 1710.5ATXN1, ATXN3
37respiratory failure10.5GAA, PIK3C2A
38pneumonia10.4
39distal muscular dystrophy10.4PIK3C2A, GAA
40abdominal aortic aneurysm10.4AAAS
41peripheral vascular disease10.4ALB
42churg-strauss syndrome10.4PRTN3, IL5
43inclusion body myositis10.4
44aspiration pneumonia10.4
45parkinson's disease10.4
46myositis10.4
47pharyngitis10.4
48aneurysm10.4
49spinocerebellar degeneration10.3RPS27A, ATXN3, ATXN1
50food allergy10.3C1S, IL5

Graphical network of the top 20 diseases related to Dysphagia:



Diseases related to dysphagia

Symptoms for Dysphagia

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Drugs & Therapeutics for Dysphagia

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Drug clinical trials:

Search ClinicalTrials for Dysphagia

Search NIH Clinical Center for Dysphagia

Genetic Tests for Dysphagia

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Anatomical Context for Dysphagia

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MalaCards organs/tissues related to Dysphagia:

32
Brain, Testes, Tongue, Thyroid, Cortex, Heart, Colon, Lung, Eye, Bone, Thymus, Spinal cord, Skeletal muscle, Prostate, B cells

Animal Models for Dysphagia or affiliated genes

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MGI Mouse Phenotypes related to Dysphagia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8ATXN1, F3, MID1, ALB, KIT, GAA
2MP:00036317.6SALL1, CP, ATXN3, ATXN1, F3, MEGF10
3MP:00053867.3GAA, ATXN1, ATXN3, CP, SALL1, F3
4MP:00053786.6SALL1, ATXN1, PIK3C2A, TF, F3, MID1
5MP:00107686.5PIK3C2A, ATXN1, SALL1, F3, MID1, ALB
6MP:00053766.3CP, ATXN1, PIK3C2A, TF, F3, AAAS

Publications for Dysphagia

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Articles related to Dysphagia:

(show top 50)    (show all 861)
idTitleAuthorsYear
1
Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients. (24993075)
2014
2
Managing eating and drinking difficulties (dysphagia) with children who have learning disabilities: What is effective? (24414040)
2014
3
Right Aortic Arch With Kommerell Diverticulum: A Rare Cause of Dysphagia. (24744100)
2014
4
One-step supraclavicular approach to the treatment of Dysphagia lusoria. (24438543)
2014
5
Dysphagia in a 58-year-old man. (25403039)
2014
6
Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). (23747002)
2013
7
Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients. (23157278)
2013
8
Causes of dysphagia among different age groups: a systematic review of the literature. (24262954)
2013
9
Neuromuscular electrical stimulation efficacy in acute stroke feeding tube-dependent dysphagia during inpatient rehabilitation. (23478451)
2013
10
Slow esophageal propagation velocity: association with dysphagia for solids. (23181386)
2013
11
Severe Dysphagia after inferior alveolar nerve block preceded by cervical botolinum toxin injection: a case report. (24396583)
2013
12
Dysphagia lusoria in an infant. (23415621)
2013
13
Calcific retropharyngeal tendinitis of the longus colli muscle. Answer to the e-quid "Acute cervical pain and dysphagia in a 43A year-old man". (23357277)
2013
14
Functional Magnetic Stimulation Using a Parabolic Coil for Dysphagia After Stroke. (24320695)
2013
15
Dysphagia in a patient with recurrent small-cell lung cancer. (23159301)
2013
16
Dysphagia lusoria: Report of a series of six cases. (23623447)
2013
17
Delayed dysphagia from a foreign body granuloma mimicking a subepithelial neoplasm. (23103909)
2013
18
Characteristics of dysphagia in children with cerebral palsy, related to gross motor function. (23739271)
2013
19
Author reply to "Oropharyngeal dysphagia in Parkinson's disease: comments on paper by Kalf et al." by Boot & Chaudhuri. (22902809)
2013
20
Incidence and risk factors for dysphagia after anterior cervical fusion. (23873236)
2013
21
Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia. (22722616)
2013
22
Impaired postoperative EGJ relaxation as a determinant of post laparoscopic fundoplication dysphagia: a study with high-resolution manometry before and after surgery. (22717797)
2012
23
Multiple cervical levels: increased risk of dysphagia and dysphonia during anterior cervical discectomy. (22828154)
2012
24
Effects of transcranial direct current stimulation (tDCS) on post-stroke dysphagia. (22572022)
2012
25
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
26
Dysphagia caused by garlic induced esophagitis. (23062683)
2012
27
Intraductal papillary mucinous neoplasm of the oesophagus: an unusual case of dysphagia. (22391370)
2012
28
Dysphagia due to adenoid cystic carcinoma of the base of the tongue. (22737963)
2012
29
Screening and clinical assessment of oropharyngeal dysphagia. (23052000)
2012
30
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
31
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
32
Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction. (19828479)
2010
33
Dysphagia due to tardive dyskinesia. (22174539)
2010
34
A modified approach to laparoscopic antireflux surgery may decrease postoperative dysphagia and gas bloat syndrome. (20551800)
2010
35
Kommerell diverticulum, right-sided aorta, and left aberrant subclavian artery in a patient with dysphagia. (19660293)
2010
36
Dysphagia lusoria. (19667034)
2009
37
Mature cystic teratoma: Unusual presentation as dysphagia. (20108063)
2009
38
Eosinophilic esophagitis : a cause of dysphagia]. (18214405)
2008
39
Dysphagia due to triple A syndrome: successful treatment of achalasia by balloon dilatation. (17853339)
2007
40
Cerebrospinal fluid leak after anterior cervical disc fusion: an unusual cause of dysphagia and neck mass. (17721401)
2007
41
Severe and prolonged dysphagia complicating botulinum toxin A injections for dystonia in Machado-Joseph disease. (8618703)
1996
42
A note on the historical aspects of dysphagia lusoria. (1642389)
1992
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Dysphagia due to simultaneous laryngocele and Zenker's diverticulum. (3917519)
1985
45
Mitral valve disease and dysphagia. (6241564)
1984
46
Dysphagia lusoria: case report in a Nigerian girl. (7117182)
1982
47
Dysphagia lusoria: anomalous origin of the right subclavian artery. Demonstration by computed tomography. (7341258)
1981
48
Oropharyngeal dysphagia in patients with oculopharyngeal muscular dystrophy. (679079)
1978
49
Dysphagia lusoria. (13481400)
1957
50
Dysphagia lusoria: an unusual case. (14952469)
1952

Variations for Dysphagia

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Expression for genes affiliated with Dysphagia

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Expression patterns in normal tissues for genes affiliated with Dysphagia

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Pathways for genes affiliated with Dysphagia

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Compounds for genes affiliated with Dysphagia

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Compounds related to Dysphagia according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1ferrozine4410.0CP, TF
2ferrous ammonium sulfate4410.0TF, CP
3protamine449.8CP, F3, RPS27A
4apotransferrin449.8TF, CP
5dextran 70449.8F3, ALB
63,4-dichloroisocoumarin44 1110.7PRTN3, F3, C1S
7hepaplastin449.7F3, ALB
8kp-1019449.7ALB, TF
9dextran sulfate449.5IL5, F3, ALB
10kininogen449.5F3, ALB, C1S
11suprofen44 1110.5CP, ALB, TF
12bismuth44 2410.4TF, ALB
13dtpa449.4TF, CP, ALB
14ovomucoid449.4IL5, TF
15chloroquine44 2 50 28 1113.4TF, GAA, KIT, RPS27A
16gelfoam449.3ALB, TF
17vitamin b12449.3CP, ALB, TF
18carbohydrates449.1GAA, TF, CP, RPS27A, F3
19indomethacin44 28 61 1112.1RPS27A, CP, ALB, IL5
20ivig449.0PIK3C2A, ALB, IL5
21polysaccharide449.0TF, F3, RPS27A, GAA
22warfarin44 50 24 1111.9ALB, F3, PIK3C2A
23sodium nitroprusside448.9CP, PIK3C2A, TF, IL5
24cycloheximide448.9RPS27A, PRTN3, F3, IL5, KIT
25prostacyclin448.8TF, C1S, F3, PIK3C2A
26gold448.8PRTN3, GAA, PIK3C2A, KIT
27homocysteine44 249.8F3, CP, ALB, PIK3C2A
28tacrolimus44 50 1110.7F3, TF, IL5, ALB, RPS27A
29imatinib44 50 1110.7KIT, ALB, PRTN3, IL5, RPS27A
30uric acid44 249.6ALB, CP, PIK3C2A
31prednisolone44 28 1110.6TF, PIK3C2A, IL5, ALB
32bicarbonate448.6PIK3C2A, ALB, TF
33retinoic acid44 249.6RPS27A, KIT, PRTN3, F3, IL5, CP
34epinephrine44 24 1110.6CP, F3, PIK3C2A, TF, RPS27A
35glutamine448.5IL5, KIT, RPS27A, PABPN1, CP, ATXN3
36ascorbic acid44 249.4ALB, TF, CP, PIK3C2A
37thyroxine44 249.4CP, TF, IL5, ALB, PIK3C2A
38cysteine448.3CP, KIT, ALB, RPS27A, IL5, ATXN3
39citrate448.3PIK3C2A, ALB, F3, TF, CP
40serine448.2C1S, PRTN3, F3, IL5, KIT, RPS27A
41arginine448.2SALL1, IL5, GAA, RPS27A, PIK3C2A, C1S
42heparin44 28 24 1111.2PIK3C2A, IL5, F3, ALB, C1S, CP
43fibrinogen448.0CP, PIK3C2A, F3, TF, ALB, C1S
44methotrexate50 44 1110.0ALB, PIK3C2A, IL5, KIT, TF, GAA
45vegf447.9KIT, RPS27A, IL5, F3, TF, PIK3C2A
46testosterone44 61 24 1110.8ATXN1, ATXN3, CP, IL5, RPS27A, ALB
47lactate447.7PIK3C2A, CP, RPS27A, ALB, KIT, GAA
48aspartate447.6TF, RPS27A, CP, F3, KIT, ALB
49creatinine447.5F3, GAA, ALB, RPS27A, PABPN1, PIK3C2A
50alanine447.2CP, ALB, RPS27A, F3, PRTN3, PABPN1

GO Terms for genes affiliated with Dysphagia

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Cellular components related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.7TF, C1S, CP, ALB
2extracellular spaceGO:0056158.0TF, CP, F3, IL5, ALB, KIT
3extracellular vesicular exosomeGO:0700626.8TF, PIK3C2A, CP, PRTN3, RPS27A, ALB

Biological processes related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of JAK-STAT cascadeGO:0464279.8IL5, KIT
2cytokine-mediated signaling pathwayGO:0192219.2KIT, RPS27A, IL5, AAAS
3negative regulation of programmed cell deathGO:0430699.1ALB, KIT
4transmembrane transportGO:0550858.4CP, AAAS, RPS27A, ALB, TF

Molecular functions related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3MID1, ATXN3, TF

Products for genes affiliated with Dysphagia

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Sources for Dysphagia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet