Aliases & Classifications for Dysphagia

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Sources:
42NINDS, 43Novoseek, 60UMLS, 25ICD10
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Dysphagia, Aliases & Descriptions:

Name: Dysphagia 42 43
 
Deglutition Disorders 60


Classifications:



External Ids:

ICD1025 R13

Summaries for Dysphagia

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NINDS:42 Having trouble swallowing (dysphagia) is a symptom that accompanies a number of neurological disorders. The problem can occur at any stage of the normal swallowing process as food and liquid move from the mouth, down the back of the throat, through the esophagus and into the stomach. Difficulties can range from a total inability to swallow, to coughing or choking because the food or liquid is entering the windpipe, which is referred to as aspiration. When aspiration is frequent a person can be at risk of developing pneumonia. Food may get "stuck" in the throat or individuals may drool because they cannot swallow their saliva. Neurological conditions that can cause swallowing difficulties are: stroke (the most common cause of dysphagia); traumatic brain injury; cerebral palsy; Parkinson disease and other degenerative neurological disorders such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), multiple sclerosis, progressive supranuclear palsy, Huntington disease, and myasthenia gravis. Muscular dystrophy and myotonic dystrophy are accompanied by dysphagia, which is also the cardinal symptom of oculopharyngeal muscular dystrophy, a rare, progressive genetic disorder.

MalaCards based summary: Dysphagia, also known as deglutition disorders, is related to oculopharyngeal muscular dystrophy and muscular dystrophy. An important gene associated with Dysphagia is MEGF10 (multiple EGF-like-domains 10), and among its related pathways is Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds ferrous ammonium sulfate and ferrozine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tongue, and related mouse phenotypes are muscle and nervous system.

Wikipedia:63 Dysphagia is the medical term for the symptom of difficulty in swallowing. Although classified under... more...

Related Diseases for Dysphagia

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Diseases related to Dysphagia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 504)
idRelated DiseaseScoreTop Affiliating Genes
1oculopharyngeal muscular dystrophy31.4PABPN1
2muscular dystrophy31.2PIK3C2A, PABPN1, GAA
3machado-joseph disease30.9ATXN3
4pericardial effusion30.8PIK3C2A
5eosinophilic gastroenteritis30.4IL5
6dementia30.4PIK3C2A, TIMM8A, CP, RPS27A
7multiple system atrophy30.4ATXN1, ATXN3, RPS27A
8neuropathy30.4ALB, PABPN1, PIK3C2A
9spinocerebellar ataxia 130.4ATXN1, ATXN3
10spinocerebellar ataxia 1730.3ATXN1, ATXN3
11polymyositis30.3PIK3C2A, RPS27A, GAA
12myopathy30.2PIK3C2A, PABPN1, RPS27A, SIL1, GAA
13spinocerebellar ataxia30.2RPS27A, ATXN3, ATXN1
14eosinophilia30.1IL5, PRTN3, PIK3C2A
15hypereosinophilic syndrome29.9IL5, KIT
16galactosemia29.8CP, F3, ALB
17protein-energy malnutrition29.7TF, ALB
18wilson disease29.7CP, TF
19dysphagia lusoria10.8
20esophagitis10.7
21cervicitis10.7
22hyperostosis10.6
23diffuse idiopathic skeletal hyperostosis10.6
24baller-gerold syndrome10.5SALL1
25scleritis10.5PRTN3
26legionaire disease10.5PIK3C2A
27capillary leak syndrome10.5C1S
28status asthmaticus10.5PIK3C2A
29neuronal intranuclear inclusion disease10.5RPS27A
30imperforate anus10.5SALL1
31kimura disease10.5IL5
32aceruloplasminemia10.5CP
33dentatorubro-pallidoluysian atrophy10.5ATXN1, ATXN3
34strongyloidiasis10.5IL5
35huntington disease10.5ATXN1, ATXN3
36hereditary ataxia10.5ATXN1, ATXN3
37spinocerebellar ataxia 1210.5ATXN1, ATXN3
38respiratory failure10.4GAA, PIK3C2A
39pneumonia10.4
40distal muscular dystrophy10.4PIK3C2A, GAA
41abdominal aortic aneurysm10.4AAAS
42peripheral vascular disease10.4ALB
43churg-strauss syndrome10.4PRTN3, IL5
44inclusion body myositis10.4
45pharyngitis10.4
46aspiration pneumonia10.4
47aneurysm10.4
48myopathy, areflexia, respiratory distress, and dysphagia, early-onset10.4
49myositis10.4
50spinocerebellar degeneration10.3RPS27A, ATXN3, ATXN1

Graphical network of the top 20 diseases related to Dysphagia:



Diseases related to dysphagia

Symptoms for Dysphagia

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Drugs & Therapeutics for Dysphagia

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Drug clinical trials:

Search ClinicalTrials for Dysphagia

Search NIH Clinical Center for Dysphagia

Genetic Tests for Dysphagia

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Anatomical Context for Dysphagia

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MalaCards organs/tissues related to Dysphagia:

31
Brain, Testes, Tongue, Thyroid, Cortex, Heart, Colon, Lung, Eye, Bone, Thymus, Spinal cord, Skeletal muscle, Prostate, B cells

Animal Models for Dysphagia or affiliated genes

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MGI Mouse Phenotypes related to Dysphagia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8ATXN1, F3, MID1, ALB, KIT, GAA
2MP:00036317.6SALL1, CP, ATXN3, ATXN1, F3, MEGF10
3MP:00053867.3GAA, ATXN1, ATXN3, CP, SALL1, F3
4MP:00053786.6SALL1, ATXN1, PIK3C2A, TF, F3, MID1
5MP:00107686.5PIK3C2A, ATXN1, SALL1, F3, MID1, ALB
6MP:00053766.3CP, ATXN1, PIK3C2A, TF, F3, AAAS

Publications for Dysphagia

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Articles related to Dysphagia:

(show top 50)    (show all 891)
idTitleAuthorsYear
1
Klebsiella pneumoniae in a patient with hoarseness and dysphagia rather than pharyngitis. (25623636)
2015
2
Management of Dysphagia Pre- and Postoperatively in a Case of Eagle's Syndrome. (25852957)
2015
3
Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients. (24993075)
2014
4
Managing eating and drinking difficulties (dysphagia) with children who have learning disabilities: What is effective? (24414040)
2014
5
Right Aortic Arch With Kommerell Diverticulum: A Rare Cause of Dysphagia. (24744100)
2014
6
One-step supraclavicular approach to the treatment of Dysphagia lusoria. (24438543)
2014
7
Dysphagia in a 58-year-old man. (25403039)
2014
8
Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). (23747002)
2013
9
Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients. (23157278)
2013
10
Neuromuscular electrical stimulation efficacy in acute stroke feeding tube-dependent dysphagia during inpatient rehabilitation. (23478451)
2013
11
Slow esophageal propagation velocity: association with dysphagia for solids. (23181386)
2013
12
Severe Dysphagia after inferior alveolar nerve block preceded by cervical botolinum toxin injection: a case report. (24396583)
2013
13
Dysphagia lusoria in an infant. (23415621)
2013
14
Calcific retropharyngeal tendinitis of the longus colli muscle. Answer to the e-quid "Acute cervical pain and dysphagia in a 43A year-old man". (23357277)
2013
15
Functional Magnetic Stimulation Using a Parabolic Coil for Dysphagia After Stroke. (24320695)
2013
16
Dysphagia in a patient with recurrent small-cell lung cancer. (23159301)
2013
17
Dysphagia lusoria: Report of a series of six cases. (23623447)
2013
18
Delayed dysphagia from a foreign body granuloma mimicking a subepithelial neoplasm. (23103909)
2013
19
Characteristics of dysphagia in children with cerebral palsy, related to gross motor function. (23739271)
2013
20
Author reply to "Oropharyngeal dysphagia in Parkinson's disease: comments on paper by Kalf et al." by Boot & Chaudhuri. (22902809)
2013
21
Incidence and risk factors for dysphagia after anterior cervical fusion. (23873236)
2013
22
Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia. (22722616)
2013
23
Impaired postoperative EGJ relaxation as a determinant of post laparoscopic fundoplication dysphagia: a study with high-resolution manometry before and after surgery. (22717797)
2012
24
Multiple cervical levels: increased risk of dysphagia and dysphonia during anterior cervical discectomy. (22828154)
2012
25
Effects of transcranial direct current stimulation (tDCS) on post-stroke dysphagia. (22572022)
2012
26
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
27
Dysphagia caused by garlic induced esophagitis. (23062683)
2012
28
Intraductal papillary mucinous neoplasm of the oesophagus: an unusual case of dysphagia. (22391370)
2012
29
Dysphagia due to adenoid cystic carcinoma of the base of the tongue. (22737963)
2012
30
Screening and clinical assessment of oropharyngeal dysphagia. (23052000)
2012
31
Dysphagia caused by diffuse idiopathic skeletal hyperostosis. (21907632)
2011
32
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
33
Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction. (19828479)
2010
34
Dysphagia due to tardive dyskinesia. (22174539)
2010
35
A modified approach to laparoscopic antireflux surgery may decrease postoperative dysphagia and gas bloat syndrome. (20551800)
2010
36
Kommerell diverticulum, right-sided aorta, and left aberrant subclavian artery in a patient with dysphagia. (19660293)
2010
37
Mature cystic teratoma: Unusual presentation as dysphagia. (20108063)
2009
38
Eosinophilic esophagitis : a cause of dysphagia]. (18214405)
2008
39
Dysphagia due to triple A syndrome: successful treatment of achalasia by balloon dilatation. (17853339)
2007
40
Cerebrospinal fluid leak after anterior cervical disc fusion: an unusual cause of dysphagia and neck mass. (17721401)
2007
41
Severe and prolonged dysphagia complicating botulinum toxin A injections for dystonia in Machado-Joseph disease. (8618703)
1996
42
A note on the historical aspects of dysphagia lusoria. (1642389)
1992
43
Cervical involvement of diffuse idiopathic skeletal hyperostosis with dysphagia and rhinolalia. (3266838)
1988
44
Dysphagia due to simultaneous laryngocele and Zenker's diverticulum. (3917519)
1985
45
Mitral valve disease and dysphagia. (6241564)
1984
46
Dysphagia lusoria: case report in a Nigerian girl. (7117182)
1982
47
Dysphagia lusoria: anomalous origin of the right subclavian artery. Demonstration by computed tomography. (7341258)
1981
48
Oropharyngeal dysphagia in patients with oculopharyngeal muscular dystrophy. (679079)
1978
49
Dysphagia lusoria. (13481400)
1957
50
Dysphagia lusoria: an unusual case. (14952469)
1952

Variations for Dysphagia

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Expression for genes affiliated with Dysphagia

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Search GEO for disease gene expression data for Dysphagia.

Pathways for genes affiliated with Dysphagia

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Compounds for genes affiliated with Dysphagia

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Compounds related to Dysphagia according to GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate4310.0CP, TF
2ferrozine4310.0CP, TF
3protamine439.8RPS27A, F3, CP
4apotransferrin439.8CP, TF
5dextran 70439.8ALB, F3
63,4-dichloroisocoumarin43 1210.7C1S, PRTN3, F3
7hepaplastin439.7ALB, F3
8kp-1019439.7TF, ALB
9ovomucoid439.7IL5, TF
10dextran sulfate439.5F3, IL5, ALB
11kininogen439.5ALB, F3, C1S
12suprofen43 1210.5TF, CP, ALB
13bismuth43 2410.4ALB, TF
14dtpa439.4TF, CP, ALB
15chloroquine43 2 49 28 1213.4GAA, KIT, RPS27A, TF
16vitamin b12439.3TF, CP, ALB
17carbohydrates439.1GAA, RPS27A, F3, CP, TF
18indomethacin43 28 59 1212.1CP, IL5, RPS27A, ALB
19ivig439.0ALB, IL5, PIK3C2A
20polysaccharide439.0GAA, RPS27A, F3, TF
21p-007438.9KIT, PIK3C2A
22warfarin43 49 24 1211.9PIK3C2A, F3, ALB
23sodium nitroprusside438.9TF, PIK3C2A, CP, IL5
24cycloheximide438.9PRTN3, F3, IL5, RPS27A, KIT
25prostacyclin438.8TF, PIK3C2A, C1S, F3
26gold438.8GAA, KIT, PRTN3, PIK3C2A
27homocysteine43 249.8PIK3C2A, CP, F3, ALB
28tacrolimus43 49 1210.7TF, F3, IL5, RPS27A, ALB
29imatinib43 49 1210.7PRTN3, IL5, RPS27A, ALB, KIT
30uric acid43 249.6PIK3C2A, CP, ALB
31prednisolone43 28 1210.6TF, PIK3C2A, IL5, ALB
32bicarbonate438.6TF, PIK3C2A, ALB
33retinoic acid43 249.6CP, PRTN3, F3, IL5, RPS27A, KIT
34epinephrine43 24 1210.6TF, PIK3C2A, CP, F3, RPS27A
35glutamine438.5KIT, TF, ATXN1, ATXN3, CP, PABPN1
36ascorbic acid43 249.4TF, PIK3C2A, CP, ALB
37thyroxine43 249.4TF, PIK3C2A, CP, IL5, ALB
38cysteine438.3ATXN3, CP, F3, IL5, RPS27A, ALB
39citrate438.3TF, PIK3C2A, CP, F3, ALB
40serine438.2C1S, CP, PRTN3, F3, IL5, RPS27A
41arginine438.2PIK3C2A, C1S, CP, PABPN1, SALL1, IL5
42heparin43 28 24 1211.2PIK3C2A, C1S, CP, F3, IL5, ALB
43fibrinogen438.0TF, PIK3C2A, C1S, CP, F3, ALB
44methotrexate49 43 1210.0TF, PIK3C2A, IL5, ALB, KIT, GAA
45vegf437.9TF, PIK3C2A, CP, F3, IL5, RPS27A
46testosterone43 59 24 1210.8PIK3C2A, ATXN1, ATXN3, CP, IL5, RPS27A
47lactate437.7TF, PIK3C2A, CP, RPS27A, ALB, KIT
48aspartate437.6TF, PIK3C2A, CP, F3, RPS27A, ALB
49creatinine437.5TF, PIK3C2A, CP, PABPN1, F3, RPS27A
50alanine437.2TF, PIK3C2A, CP, PABPN1, PRTN3, F3

GO Terms for genes affiliated with Dysphagia

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Cellular components related to Dysphagia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725628.7ALB, CP, C1S, TF
2extracellular spaceGO:00056158.0KIT, ALB, IL5, F3, CP, TF
3extracellular vesicular exosomeGO:00700626.8TF, PIK3C2A, CP, PRTN3, RPS27A, ALB

Biological processes related to Dysphagia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of JAK-STAT cascadeGO:00464279.8KIT, IL5
2cytokine-mediated signaling pathwayGO:00192219.2KIT, RPS27A, IL5, AAAS
3negative regulation of programmed cell deathGO:00430699.1KIT, ALB
4transmembrane transportGO:00550858.4TF, CP, AAAS, RPS27A, ALB

Molecular functions related to Dysphagia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.3MID1, ATXN3, TF

Products for genes affiliated with Dysphagia

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Sources for Dysphagia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet