MCID: DYS073
MIFTS: 42

Dysphagia malady

Summaries for Dysphagia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Having trouble swallowing (dysphagia) is a symptom that accompanies a number of neurological disorders. The problem can occur at any stage of the normal swallowing process as food and liquid move from the mouth, down the back of the throat, through the esophagus and into the stomach. Difficulties can range from a total inability to swallow, to coughing or choking because the food or liquid is entering the windpipe, which is referred to as aspiration. When aspiration is frequent a person can be at risk of developing pneumonia. Food may get "stuck" in the throat or individuals may drool because they cannot swallow their saliva. Neurological conditions that can cause swallowing difficulties are: stroke (the most common cause of dysphagia); traumatic brain injury; cerebral palsy; Parkinson disease and other degenerative neurological disorders such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), multiple sclerosis, progressive supranuclear palsy, Huntington disease, and myasthenia gravis. Muscular dystrophy and myotonic dystrophy are accompanied by dysphagia, which is also the cardinal symptom of oculopharyngeal muscular dystrophy, a rare, progressive genetic disorder.

MalaCards: Dysphagia, also known as deglutition disorders, is related to oculopharyngeal muscular dystrophy and dysphagia lusoria. An important gene associated with Dysphagia is MEGF10 (multiple EGF-like-domains 10). The compounds gold and glutamine have been mentioned in the context of this disorder. Affiliated tissues include tongue, spinal cord and brain, and related mouse phenotype behavior/neurological.

Wikipedia:64 Dysphagia is the medical term for the symptom of difficulty in swallowing. Although classified under... more...

Aliases & Classifications for Dysphagia

Sources:
44NINDS, 45Novoseek, 61UMLS, 25ICD10
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Related Diseases for Dysphagia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dysphagia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 314)
idRelated DiseaseScoreTop Affiliating Genes
1oculopharyngeal muscular dystrophy30.5PABPN1, GAA
2dysphagia lusoria10.8
3diffuse idiopathic skeletal hyperostosis10.5
4aberrant subclavian artery10.5
5inclusion body myositis10.4
6aspiration pneumonia10.3
7eosinophilic esophagitis10.3
8aortic aneurysm10.3
9esophageal tuberculosis10.2
10thoracic aortic aneurysm10.2
11odontoma dysphagia syndrome10.2
12plummer vinson syndrome10.2
13kommerell diverticulum10.2
14parkinson's disease10.2
15tuberculosis10.2
16swallowing disorders10.2
17bronchogenic cyst10.2
18spondylosis10.2
19amyotrophic lateral sclerosis10.2
20stroke, ischemic10.1
21lateral sclerosis10.1
22subclavian artery aneurysm10.1
23achalasia10.1
24duchenne muscular dystrophy10.1
25n syndrome10.1
26myopathy, early-onset, areflexia, respiratory distress, and dysphagia10.1
27brain injury10.1
28myotonia congenita, atypical, acetazolamide-responsive10.1
29ramsay-hunt syndrome10.1
30foodborne botulism10.0
31lateral medullary syndrome10.0
32mutism10.0
33gastroparesis10.0
34eagle syndrome10.0
35oral cancer10.0
36ataxia10.0
37sleep apnea10.0
38ophthalmoplegia10.0MYH3
39spinocerebellar ataxia type 310.0ATXN3
40neuropathy10.0PABPN1, PIK3C2A
41sensorineural hearing loss10.0SALL1, TIMM8A
42olivopontocerebellar atrophy10.0ATXN3, ATXN1
43hereditary ataxia10.0ATXN3, ATXN1
44spinocerebellar degeneration10.0ATXN3, ATXN1
45mental retardation10.0GAA, TIMM8A
46respiratory failure10.0PIK3C2A, GAA
47myotonic dystrophy10.0GAA, PIK3C2A
48spinocerebellar ataxia type 1210.0ATXN1, ATXN3
49scleritis10.0PRTN3
50spinocerebellar ataxia type 1710.0ATXN3, ATXN1

Graphical network of the top 20 diseases related to Dysphagia:



Diseases related to dysphagia

Clinical Features for Dysphagia

Drugs & Therapeutics for Dysphagia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dysphagia

Search CenterWatch for Dysphagia

Genetic Tests for Dysphagia

Anatomical Context for Dysphagia

Sources:
33MalaCards
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MalaCards organs/tissues related to Dysphagia:

33
Tongue, Spinal cord, Brain, Lung, Thymus, Cortex, Heart, Skeletal muscle, Colon, Thyroid, Prostate, B cells, Cingulate cortex

Animal Models for Dysphagia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Dysphagia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4CP, SALL1, GAA, ATXN3, ATXN1, IL5

Publications for Dysphagia

Sources:
51PubMed
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Articles related to Dysphagia:

(show top 50)    (show all 826)
idTitleAuthorsYear
1
Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients. (23157278)
2013
2
Incidence and risk factors for dysphagia after anterior cervical fusion. (23873236)
2013
3
Identification of preoperative risk factors for persistent postoperative dysphagia after laparoscopic antireflux surgery. (24190371)
2013
4
Dysphagia caused by a left atrial myxoma. (24021954)
2013
5
Severe Dysphagia, Candidiasis, and an Oesophageal Mass, but Over 50 Biopsies Negative for Malignancy. (23907748)
2013
6
Dysphagia and trismus in an elderly woman. (23322422)
2013
7
A novel method for the treatment of dysphagia lusoria due to aberrant right subclavian artery. (23243037)
2013
8
Dysphagia after anterior cervical discectomy and fusion: a prospective study comparing two anterior surgical approaches. (23277296)
2013
9
Transnasal endoscopic evaluation of swallowing: a bedside technique to evaluate ability to swallow pureed diets in elderly patients with dysphagia. (23936875)
2013
10
Free Jejunal Graft Repair after PharyngoLaryngo-Esophagectomy-Risk Factor Analysis for Postoperative Dysphagia. (23411842)
2013
11
Glottal insufficiency with aspiration risk in dysphagia. (24262963)
2013
12
Head and neck cancer and dysphagia; caring for carers. (23208850)
2013
13
Delayed Dysphagia after removal of foreign bodies near upper esophageal sphincter. (24199017)
2013
14
Oropharyngeal dysphagia and gross motor skills in children with cerebral palsy. (23589816)
2013
15
Validity and reliability of the korean version of the MD anderson Dysphagia inventory for head and neck cancer patients. (24020028)
2013
16
Title: Postoperative Prevertebral Soft Tissue Swelling Does Not Affect the Development of Chronic Dysphagia Following Anterior Cervical Spine Surgery. (23380821)
2013
17
Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge/22q11 Deletion Syndrome. (24357327)
2013
18
Detecting signs of dysphagia in patients with Alzheimer's disease with oral feeding in daily life. (23992204)
2013
19
Understanding dysphagia: a rapidly emerging problem. (24262966)
2013
20
Subjective dysphagia in older care home residents: A cross-sectional, multi-centre point prevalence measurement. (24238894)
2013
21
Intraductal papillary mucinous neoplasm of the oesophagus: an unusual case of dysphagia. (22391370)
2012
22
Clinical efficacy and randomized clinical trials in dysphagia. (22943582)
2012
23
Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy. (22525080)
2012
24
Stroke, dysphagia and oral care: what is best practice? (22662463)
2012
25
Dysphagia lusoria. (22386188)
2012
26
High-resolution Manometry for Oropharyngeal Dysphagia in a Patient With Large Cervical Osteophytes. (22837884)
2012
27
Dysphagia in Duchenne muscular dystrophy versus myotonic dystrophy type 1. (22987688)
2012
28
Cricopharyngeal dilatation for the long-term treatment of dysphagia in oculopharyngeal muscular dystrophy. (21805106)
2012
29
Risk factors for postoperative dysphagia in oral cancer. (22790335)
2012
30
Current evaluation of upper oesophageal sphincter opening in dysphagia practice: an international SLT survey. (22369056)
2012
31
Laparoscopic revision of Roux-en-Y gastric bypass for dysphagia and bile reflux. (20870186)
2010
32
Dysphagia and submandibular swelling. Eagle syndrome. (20807908)
2010
33
Inspiratory stridor and dysphagia in two newborn infants caused by ectopic thymus tissue. (19104836)
2009
34
Reversible oropharyngeal dysphagia secondary to cricopharyngeal sphincter achalasia in a patient with myasthenia gravis: a case report. (20184678)
2009
35
Adult-onset dysphagia lusoria from an uncommon vascular ring: a case report and review of the literature. (18829585)
2009
36
Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. (18379741)
2008
37
A carotid artery dissection presenting with dysphagia due to a dilation of upper oesophagus. (18072337)
2007
38
Dysphagia lusoria. (17931276)
2007
39
An unusual case of dysphagia and chest pain in a non-HIV patient: esophageal tuberculosis. (17398209)
2007
40
Mediastinal tuberculous lymphadenitis presenting as an esophageal intramural tumor: a very rare but important cause for dysphagia. (18023110)
2007
41
Predictors of aspiration pneumonia: how important is dysphagia? (9513300)
1998
42
Dysphagia in individuals with no history of bulbar polio. (7611657)
1995
43
Neurogenic dysphagia resulting from Chiari malformations. (1584383)
1992
44
Dysphagia in Chiari malformations. (2215969)
1990
45
Dysphagia due to cervical spondylosis. (4056603)
1985
46
Adult dysphagia lusoria. Treatment by arterial division and reestablishment of vascular continuity. (3886318)
1985
47
Aneurysm of anomalous subclavian artery: an unusal cause of dysphagia lusoria in childhood. (629616)
1978
48
A new operation for symptomatic aberrant right subclavian artery in the adult (dysphagia lusoria). (5764134)
1969
49
Sideropenic dysphagia (Plummer-Vinson syndrome); case report and discussion. (14925626)
1952
50
GLOSSITIS, oral fissures, and dysphagia as signs of iron deficiency. (20275438)
1946

Genetic Variations for Dysphagia

Expression for genes affiliated with Dysphagia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysphagia

Search GEO for disease gene expression data for Dysphagia.

Pathways for genes affiliated with Dysphagia

Compounds for genes affiliated with Dysphagia

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Dysphagia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gold459.6PRTN3, PIK3C2A, GAA
2glutamine459.6CP, PABPN1, IL5, ATXN1, ATXN3
3sodium nitroprusside459.4CP, IL5, PIK3C2A
4testosterone45 60 11 2412.3PIK3C2A, ATXN3, ATXN1, IL5, CP
5arginine459.2SALL1, GAA, PIK3C2A, IL5, PABPN1, CP

GO Terms for genes affiliated with Dysphagia

Sources:
16Gene Ontology
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Cellular components related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear inclusion bodyGO:04240510.2ATXN1, ATXN3

Biological processes related to Dysphagia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to heatGO:03460510.2SLC52A3, ATXN3
2small molecule metabolic processGO:0442818.7AAAS, SLC52A3, SLC19A3, NUP62, PIK3C2A, NDUFA12

Products for genes affiliated with Dysphagia

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Sources for Dysphagia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet