EAF
MCID: EF001
MIFTS: 25

Eaf (EAF) malady

Summaries for Eaf

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33MalaCards
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MalaCards: Eaf, also known as sinonasal eosinophilic angiocentric fibrosis, is related to lacrimal duct obstruction and kimura disease. An important gene associated with Eaf is CD22 (CD22 molecule). Affiliated tissues include lung, prostate and b cells.

Aliases & Classifications for Eaf

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43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

eaf 43
sinonasal eosinophilic angiocentric fibrosis 43
disorder characterized by eosinophilia 61
eosinophilic angiocentric fibrosis 43


Related Diseases for Eaf

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Eaf via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1lacrimal duct obstruction10.3
2kimura disease10.1
3loeffler endocarditis10.1
4hepatocellular fibrolamellar carcinoma10.1
5eosinophilic cryptitis10.1
6familial eosinophilia10.1
7leopard syndrome10.0
8asthma10.0
9deafness onychodystrophy osteodystrophy and mental retardation syndrome10.0

Graphical network of diseases related to Eaf:



Diseases related to eaf

Clinical Features for Eaf

Drugs & Therapeutics for Eaf

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Eaf

Search CenterWatch for Eaf

Genetic Tests for Eaf

Anatomical Context for Eaf

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33MalaCards
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MalaCards organs/tissues related to Eaf:

33
Lung, Prostate, B cells

Animal Models for Eaf or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Eaf

Sources:
51PubMed
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Articles related to Eaf:

(show all 12)
idTitleAuthorsYear
1
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells. (21483694)
2011
2
Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53. (19826414)
2010
3
Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19. (20161747)
2010
4
Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36. (18984594)
2008
5
Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. (18212047)
2008
6
U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. (17873910)
2008
7
FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity. (17395368)
2007
8
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. (16114057)
2006
9
Expression of murine ELL-associated factor 2 (Eaf2) is developmentally regulated. (14517999)
2003
10
ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. (12446457)
2003
11
ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. (12686606)
2003
12
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. (11418481)
2001

Genetic Variations for Eaf

Expression for genes affiliated with Eaf

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eaf

Search GEO for disease gene expression data for Eaf.

Pathways for genes affiliated with Eaf

Compounds for genes affiliated with Eaf

GO Terms for genes affiliated with Eaf

Sources:
16Gene Ontology
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Cellular components related to Eaf according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ELL-EAF complexGO:03278310.1EAF2, EAF1
2NuA4 histone acetyltransferase complexGO:0352679.8MEAF6, ING3
3nucleusGO:0056348.8VPS72, TFPT, PHF12, MEAF6, AIRE, H2AFZ

Biological processes related to Eaf according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone H4-K16 acetylationGO:04398410.1MSL3, MEAF6
2regulation of DNA-dependent transcription, elongationGO:03278410.0TCEA1, TCEA2
3histone H2A acetylationGO:0439689.8ING3, MEAF6
4transcription, DNA-dependentGO:0063519.3EAF1, VPS72, TFPT, MEAF6, AIRE, ING3

Molecular functions related to Eaf according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA bindingGO:0036779.4VPS72, TFPT, H2AFZ, TCEA2, TCEA1, MSL3
2protein bindingGO:0055158.4VPS72, TFPT, PHF12, MEAF6, AIRE, CD22

Products for genes affiliated with Eaf

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eaf

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet