MCID: EF001
MIFTS: 23

Eaf malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Eaf

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Sources:
46NIH Rare Diseases, 52Orphanet, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Eaf:

Name: Eaf 46
Eosinophilic Angiocentric Fibrosis 46 52
 
Igg4-Related Eosinophilic Angiocentric Fibrosis 52
Sinonasal Eosinophilic Angiocentric Fibrosis 46

Characteristics:

Orphanet epidemiological data:

52
eosinophilic angiocentric fibrosis:
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult

Classifications:



External Ids:

Orphanet52 ORPHA449566
ICD10 via Orphanet29 J39.8

Summaries for Eaf

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MalaCards based summary: Eaf, also known as eosinophilic angiocentric fibrosis, is related to leopard syndrome and deafness onychodystrophy osteodystrophy and mental retardation syndrome. An important gene associated with Eaf is EAF1 (ELL Associated Factor 1). Affiliated tissues include bone, testes and spleen.

Related Diseases for Eaf

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Diseases related to Eaf via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1leopard syndrome10.0
2deafness onychodystrophy osteodystrophy and mental retardation syndrome10.0
3sinusitis9.9
4orbital granuloma9.9
5lacrimal duct obstruction9.9
6compartment syndrome9.9
7neuropathy9.9
8asthma9.9
9mastitis9.9
10eales disease9.5EAF1, EAF2

Graphical network of diseases related to Eaf:



Diseases related to eaf

Symptoms for Eaf

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Drugs & Therapeutics for Eaf

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Drugs for Eaf (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ThalidomidePhase 1106050-35-15426
Synonyms:
( inverted question mark)-Thalidomide
(+)-Thalidomide
(+-)-N-(2,6-dioxo-3-Piperidyl)phthalimide
(+-)-Thalidomide
(+/-)-THALIDOMIDE
(?)-Thalidomide
(±)-N-(2,6-dioxo-3-piperidyl)phthalimide
(±)-thalidomide
.alpha.-(N-Phthalimido)glutarimide
.alpha.-N-Phthalylglutaramide
.alpha.-Phthalimidoglutarimide
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
14088-68-7
2,6-Dioxo-3-phthalimidopiperidine
2,6-dioxo-3-phthalimidopiperidine
3-Phthalimidoglutarimide
50-35-1
731-40-8
AB00052362
AC-917
AC1L1KBZ
AC1Q6FJA
AI3-50606
Algosediv
Asidon 3
Asmadion
Asmaval
BPBio1_000159
BRD-A93255169-001-06-9
BRN 0030233
BSPBio_000143
BSPBio_001156
BSPBio_003330
Bio1_000387
Bio1_000876
Bio1_001365
Bio2_000418
Bio2_000898
Bonbrain
Bonbrrin
C07910
C13H10N2O4
CCRIS 8148
CHEBI:105028
CHEMBL468
CID5426
CPD000058524
Calmore
Calmorex
Celgene Brand of Thalidomide
Contergan
Corronarobetin
D00754
D013792
DB01041
Distaval
Distaxal
Distoval
DivK1c_000051
E-217
EINECS 200-031-1
ENMD 0995
EU-0101224
Ectiluran
Enterosediv
Gastrinide
Glupan
Glutanon
Grippex
HMS1362J17
HMS1568H05
HMS1792J17
HMS1922E12
HMS1990J17
HMS2090O05
HMS2093G15
HMS500C13
HSDB 3586
Hippuzon
I06-0197
IDI1_000051
IDI1_002173
IN1061
Imida-Lab
Imida-lab
Imidan
Imidan (peyta)
Imidene
Isomin
K 17
K-17
KBio1_000051
KBio2_000496
KBio2_002322
KBio2_003064
KBio2_004890
KBio2_005632
KBio2_007458
KBio3_000911
KBio3_000912
KBio3_002550
KBio3_002802
KBioGR_000496
KBioGR_001474
KBioGR_002322
KBioSS_000496
KBioSS_002324
Kedavon
Kevadon
LS-109463
LS-140
Lopac0_001224
Lulamin
MLS000069353
MolPort-003-665-582
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-(2,6-dioxo-3-piperidyl)phthalimide
N-Phthalimidoglutamic acid imide
N-Phthaloylglutamimide
N-Phthalyl-glutaminsaeure-imid
N-Phthalyl-glutaminsaeure-imid [German]
N-Phthalylglutamic acid imide
NCGC00015989-03
NCGC00015989-13
NCGC00024708-02
 
NCGC00024708-03
NCGC00024708-04
NCGC00024708-05
NCGC00024708-06
NCGC00024708-07
NCGC00024708-08
NCGC00024708-09
NCI60_023904
NCIOpen2_003188
NINDS_000051
NSC 527179
NSC-66847
NSC527179
NSC66847
NSC91729
NSC91730
Neaufatin
Neo
Neosedyn
Neosydyn
Nerosedyn
Neufatin
Neurodyn
Neurosedin
Neurosedym
Neurosedyn
Nevrodyn
Nibrol
Noctosediv
Noxodyn
Pangul
Pantosediv
Poly-Giron
Polygripan
Predni-Sediv
Prestwick0_000192
Prestwick1_000192
Prestwick2_000192
Prestwick3_000192
Prestwick_463
Pro-Bam M
Pro-ban M
Profarmil
Psycholiquid
Psychotablets
Quetimid
Quietoplex
S1193_Selleck
SAM002564245
SMR000058524
SPBio_000893
SPBio_002064
SPECTRUM1503607
ST51039042
Sandormin
Sedalis
Sedalis sedi-lab
Sedimide
Sedin
Sedisperil
Sedoval
Shin-naito S
Shinnibrol
Sleepan
Slipro
Softenil
Softenon
Spectrum2_000707
Spectrum3_001715
Spectrum4_001087
Spectrum5_001791
Synovir
T144_SIGMA
T150_SIGMA
T151_SIGMA
THALIDOMIDE (AIDS INITIATIVE)
Talargan
Talidomida
Talidomida [INN-Spanish]
Talidomide
Talidomide [DCIT]
Talimol
Talismol
Talizer
Telagan
Telargan
Telargean
Tensival
Thaled
Thaled (TN)
Thalidomide
Thalidomide (+ and -)
Thalidomide (JAN/USP/INN)
Thalidomide (soluble form)
Thalidomide Celgene
Thalidomide Pharmion
Thalidomide [USAN:INN:BAN]
Thalidomidum
Thalidomidum [INN-Latin]
Thalidomine USP26
Thalin
Thalinette
Thalomid
Thalomid (TM)
Thalomid (TN)
Thalomid, Thalidomide
Thalomide
Theophilcholine
UNII-4Z8R6ORS6L
UPCMLD-DP139
UPCMLD-DP139:001
Valgis
Valgraine
WLN: T56 BVNVJ C- DT6VMVTJ
WLN: T56 BVNVJ C- DT6VMVTJ -D
WLN: T56 BVNVJ C- DT6VMVTJ -L
Yodomin
alpha-(N-Phthalimido)glutarimide
alpha-N-Phthalylglutaramide
alpha-Phthalimidoglutarimide
alpha-phthalimidoglutarimide
cMAP_000022
thalidomide
α-(N-phthalimido)glutarimide
α-N-phthalylglutaramide
α-phthalimidoglutarimide
2
ApremilastPhase 160608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
Apremilastum
Aprémilast
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study to Evaluate Pharmacokinetics of Apremilast in Heatlhy Male SubjectsCompletedNCT02236988Phase 1
2Study of Ventilatory Mechanics in Patients With Sickle Cell AnemiaCompletedNCT02565849

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Genetic Tests for Eaf

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Anatomical Context for Eaf

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MalaCards organs/tissues related to Eaf:

34
Bone, Testes, Spleen

Animal Models for Eaf or affiliated genes

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Publications for Eaf

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Articles related to Eaf:

(show all 39)
idTitleAuthorsYear
1
Health status of male steel workers at an electric arc furnace (EAF) in Trentino, Italy. (26900394)
2016
2
A Study on Suitability of EAF Oxidizing Slag in Concrete: An Eco-Friendly and Sustainable Replacement for Natural Coarse Aggregate. (26421315)
2015
3
Hydrometallurgical extraction of zinc from CaO treated EAF dust in ammonium chloride solution. (26448494)
2015
4
CO2 sequestration using accelerated gas-solid carbonation of pre-treated EAF steel-making bag house dust. (25846002)
2015
5
Studies on Antifungal Potential, Primary Characterization and Mode of Action of a De Novo Cytoplasmic Protein (EAF) from Human Commensal Escherichia coli Against Aspergillus spp. (26235093)
2015
6
Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains. (26438110)
2015
7
Crystallization Control for Remediation of an FetO-rich CaO-SiO2-Al2O3-MgO EAF Waste Slag. (24410350)
2014
8
Recycling of Malaysia's electric arc furnace (EAF) slag waste into heavy-duty green ceramic tile. (25242607)
2014
9
The efficiency of quartz addition on electric arc furnace (EAF) carbon steel slag stability. (25113518)
2014
10
Characterisation of the sintering behaviour of Waelz slag from electric arc furnace (EAF) dust recycling for use in the clay ceramics industry. (24321287)
2014
11
Accelerated ageing of an EAF black slag by carbonation and percolation for long-term behaviour assessment. (24726964)
2014
12
Study on simultaneous recycling of EAF dust and plastic waste containing TBBPA. (24945793)
2014
13
Reduction behavior of zinc ferrite in EAF-dust recycling with CO gas as a reducing agent. (24921184)
2014
14
Heavy metal adsorption changes of EAF steel slag after phosphorus adsorption. (22508118)
2012
15
The use of EAF dust in cement composites: assessment of environmental impact. (19097693)
2009
16
Pathology quiz case 2. Eosinophilic angiocentric fibrosis (EAF). (19620599)
2009
17
Virulence features of atypical enteropathogenic Escherichia coli identified by the eae(+) EAF-negative stx(-) genetic profile. (19442475)
2009
18
Reproducing ten years of road ageing--accelerated carbonation and leaching of EAF steel slag. (19539979)
2009
19
A novel method to enhance polychlorinated dibenzo-p-dioxins and dibenzofurans removal by adding bio-solution in EAF dust treatment plant. (17532560)
2008
20
Role of extension arm in PEG-Hb conjugates on the stability of the tetramer: non-conservative EAF maleimide thio-PEG mediated PEGylation. (19085194)
2008
21
New evidence for rejuvenation of phosphorus retention capacity in EAF steel slag. (18767686)
2008
22
Use of EAF dust as heterogeneous catalyst in Fenton oxidation of PCP contaminated wastewaters. (16621261)
2006
23
Hydrometallurgical processing of carbon steel EAF dust. (16442223)
2006
24
Combined glassification of EAF dust and incinerator fly ash. (12656228)
2003
25
Study of the presence of fluorine in the recycled fractions during carbothermal treatment of EAF dust. (12909089)
2003
26
O-serogroups, eae gene and EAF plasmid in Escherichia coli isolates from cases of bovine mastitis in Brazil. (11844619)
2002
27
Interactions of Escherichia coli strains of non-EPEC serogroups that carry eae and lack the EAF and stx gene sequences with undifferentiated and differentiated intestinal human Caco-2 cells. (11410359)
2001
28
Linkage assignment of the last unmapped cattle erythrocyte antigen system, EAF. (10582299)
1999
29
Assessment of industrial effluent toxicity using flow-through fish egg/alevins/fry (EAF) Toxicity Test. (10094727)
1999
30
High tibial osteotomy: osteotomy in minus or hemicallotasis with EAF? (8968118)
1996
31
Survey of cytotoxin production among Escherichia coli strains characterized as enteropathogenic (EPEC) by serotyping and presence of EPEC adherence factor (EAF) sequences. (7520828)
1994
32
DNA probe analysis of diarrhoeagenic Escherichia coli: detection of EAF-positive isolates of traditional enteropathogenic E. coli serotypes among Bangladeshi paediatric diarrhoea patients. (1513347)
1992
33
Effects of methanol extract of ginkgo biloba (EGb), its ethylacetate fraction (EAF) and butanol fraction (BF) on the isolated aorta. (1507615)
1992
34
The eae gene of enteropathogenic Escherichia coli encodes a 94-kilodalton membrane protein, the expression of which is influenced by the EAF plasmid. (1682258)
1991
35
Production of eosinophil-activating factor (EAF) by peripheral blood mononuclear cells from asthma patients. (2613341)
1989
36
Eosinophil-activating factor (EAF) production by a human cell line (ESH 98) stimulated with tumour necrosis factor. (2450839)
1988
37
Fimbria-like adhesive factor (EAF 44) from verocytotoxigenic Escherichia coli of bovine origin. (2905510)
1988
38
A comparison of eosinophil-activating factor (EAF) with other monokines and lymphokines. (3489622)
1986
39
Fc-receptor-bearing cells in spleen of mice injected with cell-free Ehrlich ascites fluid (EAF). (6448644)
1980

Variations for Eaf

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Expression for genes affiliated with Eaf

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Search GEO for disease gene expression data for Eaf.

Pathways for genes affiliated with Eaf

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GO Terms for genes affiliated with Eaf

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Cellular components related to Eaf according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ELL-EAF complexGO:00327839.7EAF1, EAF2
2transcription elongation factor complexGO:00080239.4EAF1, EAF2
3nuclear speckGO:00166079.1EAF1, EAF2

Sources for Eaf

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet