EAF
MCID: EF001
MIFTS: 26

Eaf (EAF) malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Eaf

Aliases & Descriptions for Eaf:

Name: Eaf 50
Eosinophilic Angiocentric Fibrosis 50 56
Igg4-Related Eosinophilic Angiocentric Fibrosis 56
Sinonasal Eosinophilic Angiocentric Fibrosis 50

Characteristics:

Orphanet epidemiological data:

56
eosinophilic angiocentric fibrosis
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA449566
ICD10 via Orphanet 34 J39.8

Summaries for Eaf

MalaCards based summary : Eaf, also known as eosinophilic angiocentric fibrosis, is related to leopard syndrome and deafness onychodystrophy osteodystrophy and mental retardation syndrome. An important gene associated with Eaf is EAF1 (ELL Associated Factor 1), and among its related pathways/superpathways is Formation of HIV elongation complex in the absence of HIV Tat. The drugs Apremilast and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spleen.

Related Diseases for Eaf

Diseases related to Eaf via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 leopard syndrome 10.8
2 deafness onychodystrophy osteodystrophy and mental retardation syndrome 10.8
3 ectodermal dysplasia alopecia preaxial polydactyly 9.8 EAF1 EAF2
4 sinusitis 9.8
5 orbital granuloma 9.8
6 lacrimal duct obstruction 9.8
7 compartment syndrome 9.8
8 neuropathy 9.8
9 asthma 9.8
10 mastitis 9.8

Graphical network of the top 20 diseases related to Eaf:



Diseases related to Eaf

Symptoms & Phenotypes for Eaf

Drugs & Therapeutics for Eaf

Drugs for Eaf (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 1 608141-41-9 11561674
2 Analgesics Phase 1
3 Analgesics, Non-Narcotic Phase 1
4 Peripheral Nervous System Agents Phase 1
5 Angiogenesis Inhibitors Phase 1
6 Angiogenesis Modulating Agents Phase 1
7 Anti-Bacterial Agents Phase 1
8 Anti-Infective Agents Phase 1
9 Immunosuppressive Agents Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Anti-Inflammatory Agents, Non-Steroidal Phase 1
12 Antirheumatic Agents Phase 1
13
Bevacizumab Approved, Investigational 216974-75-3
14 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study to Evaluate Pharmacokinetics of Apremilast in Heatlhy Male Subjects Completed NCT02236988 Phase 1
2 Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia Completed NCT02565849
3 DSC-MRI in Measuring Relative Cerebral Blood Volume for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma Recruiting NCT03115333
4 BowelScope: Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Recruiting NCT03072472

Search NIH Clinical Center for Eaf

Genetic Tests for Eaf

Anatomical Context for Eaf

MalaCards organs/tissues related to Eaf:

39
Bone, Testes, Spleen

Publications for Eaf

Articles related to Eaf:

(show all 39)
id Title Authors Year
1
Health status of male steel workers at an electric arc furnace (EAF) in Trentino, Italy. ( 26900394 )
2016
2
Hydrometallurgical extraction of zinc from CaO treated EAF dust in ammonium chloride solution. ( 26448494 )
2015
3
A Study on Suitability of EAF Oxidizing Slag in Concrete: An Eco-Friendly and Sustainable Replacement for Natural Coarse Aggregate. ( 26421315 )
2015
4
Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains. ( 26438110 )
2015
5
Studies on Antifungal Potential, Primary Characterization and Mode of Action of a De Novo Cytoplasmic Protein (EAF) from Human Commensal Escherichia coli Against Aspergillus spp. ( 26235093 )
2015
6
CO2 sequestration using accelerated gas-solid carbonation of pre-treated EAF steel-making bag house dust. ( 25846002 )
2015
7
Accelerated ageing of an EAF black slag by carbonation and percolation for long-term behaviour assessment. ( 24726964 )
2014
8
Reduction behavior of zinc ferrite in EAF-dust recycling with CO gas as a reducing agent. ( 24921184 )
2014
9
The efficiency of quartz addition on electric arc furnace (EAF) carbon steel slag stability. ( 25113518 )
2014
10
Crystallization Control for Remediation of an FetO-rich CaO-SiO2-Al2O3-MgO EAF Waste Slag. ( 24410350 )
2014
11
Characterisation of the sintering behaviour of Waelz slag from electric arc furnace (EAF) dust recycling for use in the clay ceramics industry. ( 24321287 )
2014
12
Study on simultaneous recycling of EAF dust and plastic waste containing TBBPA. ( 24945793 )
2014
13
Recycling of Malaysia's electric arc furnace (EAF) slag waste into heavy-duty green ceramic tile. ( 25242607 )
2014
14
Heavy metal adsorption changes of EAF steel slag after phosphorus adsorption. ( 22508118 )
2012
15
Virulence features of atypical enteropathogenic Escherichia coli identified by the eae(+) EAF-negative stx(-) genetic profile. ( 19442475 )
2009
16
Reproducing ten years of road ageing--accelerated carbonation and leaching of EAF steel slag. ( 19539979 )
2009
17
Pathology quiz case 2. Eosinophilic angiocentric fibrosis (EAF). ( 19620599 )
2009
18
The use of EAF dust in cement composites: assessment of environmental impact. ( 19097693 )
2009
19
New evidence for rejuvenation of phosphorus retention capacity in EAF steel slag. ( 18767686 )
2008
20
Role of extension arm in PEG-Hb conjugates on the stability of the tetramer: non-conservative EAF maleimide thio-PEG mediated PEGylation. ( 19085194 )
2008
21
A novel method to enhance polychlorinated dibenzo-p-dioxins and dibenzofurans removal by adding bio-solution in EAF dust treatment plant. ( 17532560 )
2008
22
Hydrometallurgical processing of carbon steel EAF dust. ( 16442223 )
2006
23
Use of EAF dust as heterogeneous catalyst in Fenton oxidation of PCP contaminated wastewaters. ( 16621261 )
2006
24
Study of the presence of fluorine in the recycled fractions during carbothermal treatment of EAF dust. ( 12909089 )
2003
25
Combined glassification of EAF dust and incinerator fly ash. ( 12656228 )
2003
26
O-serogroups, eae gene and EAF plasmid in Escherichia coli isolates from cases of bovine mastitis in Brazil. ( 11844619 )
2002
27
Interactions of Escherichia coli strains of non-EPEC serogroups that carry eae and lack the EAF and stx gene sequences with undifferentiated and differentiated intestinal human Caco-2 cells. ( 11410359 )
2001
28
Linkage assignment of the last unmapped cattle erythrocyte antigen system, EAF. ( 10582299 )
1999
29
Assessment of industrial effluent toxicity using flow-through fish egg/alevins/fry (EAF) Toxicity Test. ( 10094727 )
1999
30
High tibial osteotomy: osteotomy in minus or hemicallotasis with EAF? ( 8968118 )
1996
31
Survey of cytotoxin production among Escherichia coli strains characterized as enteropathogenic (EPEC) by serotyping and presence of EPEC adherence factor (EAF) sequences. ( 7520828 )
1994
32
DNA probe analysis of diarrhoeagenic Escherichia coli: detection of EAF-positive isolates of traditional enteropathogenic E. coli serotypes among Bangladeshi paediatric diarrhoea patients. ( 1513347 )
1992
33
Effects of methanol extract of ginkgo biloba (EGb), its ethylacetate fraction (EAF) and butanol fraction (BF) on the isolated aorta. ( 1507615 )
1992
34
The eae gene of enteropathogenic Escherichia coli encodes a 94-kilodalton membrane protein, the expression of which is influenced by the EAF plasmid. ( 1682258 )
1991
35
Production of eosinophil-activating factor (EAF) by peripheral blood mononuclear cells from asthma patients. ( 2613341 )
1989
36
Eosinophil-activating factor (EAF) production by a human cell line (ESH 98) stimulated with tumour necrosis factor. ( 2450839 )
1988
37
Fimbria-like adhesive factor (EAF 44) from verocytotoxigenic Escherichia coli of bovine origin. ( 2905510 )
1988
38
A comparison of eosinophil-activating factor (EAF) with other monokines and lymphokines. ( 3489622 )
1986
39
Fc-receptor-bearing cells in spleen of mice injected with cell-free Ehrlich ascites fluid (EAF). ( 6448644 )
1980

Variations for Eaf

Expression for Eaf

Search GEO for disease gene expression data for Eaf.

Pathways for Eaf

GO Terms for Eaf

Cellular components related to Eaf according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear speck GO:0016607 9.16 EAF1 EAF2
2 transcription elongation factor complex GO:0008023 8.96 EAF1 EAF2
3 ELL-EAF complex GO:0032783 8.62 EAF1 EAF2

Biological processes related to Eaf according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 8.96 EAF1 EAF2
2 transcription elongation from RNA polymerase II promoter GO:0006368 8.62 EAF1 EAF2

Sources for Eaf

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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