MCID: ELS001
MIFTS: 47

Eales Disease malady

Eye diseases, Cardiovascular diseases categories

Summaries for Eales Disease

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinitis and retinal disease. An important gene associated with Eales Disease is SAG (S-antigen; retina and pineal gland (arrestin)), and among its related pathways are PEDF Induced Signaling and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cycloheximide and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related mouse phenotypes are muscle and reproductive system.

Wikipedia:63 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Aliases & Classifications for Eales Disease

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
eales disease:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

eales disease 42 44 48 60
idiopathic recurrent vitreal hemorrhage 42
idiopathic obliterative vasculopathy 42


External Ids:

MESH via Orphanet35 C538011
ICD10 via Orphanet26 H35.0
SNOMED-CT via Orphanet57 54122009
UMLS via Orphanet61 C0271073

Related Diseases for Eales Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Eales Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis30.8SAG
2retinal disease30.8SAG, VEGFA, RBP3, SERPINF1
3retinal vasculitis30.6SAG
4vasculitis30.6SAG, TNF, RBP3
5proliferative diabetic retinopathy30.2SERPINF1, VEGFA
6diabetic retinopathy30.2SERPINF1, SOD1, SAG, VEGFA, NOS2
7tuberculosis30.2TNF, CP, IL4, IL10, SAG, IFNG
8encephalitis30.0NOS2
9retinal ischemia30.0VEGFA
10eye disease30.0IL6
11chorioretinitis30.0RBP3, SAG
12retinal detachment30.0VEGFA, SERPINF1
13ischemia30.0SOD1, NOS2, VEGFA
14vascular disease30.0VEGFA, NOS2, F5, SOD1
15melanoma29.9VEGFA, TNF, IL10, IL4, CP, SERPINF1
16vitreous disease10.5
17choroiditis10.2
18choroid disease10.2
19hemorrhagic disease10.2
20hypersensitivity vasculitis10.2
21internuclear ophthalmoplegia10.0
22vitreous detachment10.0
23hypothyroidism10.0
24leukocyte disease10.0
25malignant choroid melanoma10.0
26neuropathy10.0
27ophthalmoplegia10.0
28peripheral neuropathy10.0
29pigmentation disease10.0
30thyroiditis10.0
31neurologic diseases10.0
32bronchopulmonary dysplasia10.0SOD1
33vitiligo10.0SOD1
34down syndrome10.0SOD1
35pulmonary fibrosis10.0SOD1
36essential hypertension10.0SOD1
37tonsillitis10.0SOD1
38dementia10.0CP
39glaucoma10.0SERPINF1
40arteriosclerosis10.0SOD1
41onchocerciasis10.0RBP3
42cystic fibrosis10.0CP
43amyotrophic lateral sclerosis10.0SOD1
44laryngeal benign neoplasm10.0CP
45nephrotic syndrome10.0TF
46sickle cell disease10.0TF
47alpha thalassemia10.0TF
48glomerulonephritis10.0NOS2
49hepatitis10.0CP
50schizophrenia10.0CP

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Clinical Features for Eales Disease

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Drugs & Therapeutics for Eales Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Eales Disease

Genetic Tests for Eales Disease

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Anatomical Context for Eales Disease

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32MalaCards
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MalaCards organs/tissues related to Eales Disease:

32
Retina, Eye

Animal Models for Eales Disease or affiliated genes

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Sources:
36MGI
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Publications for Eales Disease

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Genetic Variations for Eales Disease

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Expression for genes affiliated with Eales Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

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Sources:
51QIAGEN, 52R&D Systems, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Eales Disease according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SERPINF1
210.1IL4
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.0IFNG
4
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9.9IL6
5
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9.6IFNG, IL4
6
CFTR folding and maturation (norm and CF)
9.6CP, NOS2, SOD1
79.1IFNG, IL10, IL4
89.1IL4, IL10, IFNG
99.1NOS2, IL6, IFNG
109.0IL6, IL4, IFNG
119.0CP, NOS2, VEGFA, TF
129.0IL10, IL6, NOS2
13
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9.0VEGFA, F5, TF, SOD1
14
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9.0SOD1, TF, F5, VEGFA
15
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8.8IL4, TNF, IFNG
16
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8.7IFNG, TNF, IL10
178.7TNF, IL4, IL6
188.5IL6, IL10, TNF
198.3IL6, TNF, SOD1, IFNG
208.3NOS2, IL6, IL4, TNF
21
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8.3IL4, VEGFA, TNF, IFNG
228.2IFNG, TNF, IL6, NOS2
23
Immune response Bacterial infections in normal airways
8.2IFNG, TNF, IL6, NOS2
248.2NOS2, IL6, VEGFA, TF, IFNG
25
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8.2IFNG, TNF, IL4, IL6
26
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8.1IFNG, TNF, IL10, IL6
278.1IFNG, TNF, IL10, IL6
28
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7.9IFNG, TNF, IL6, NOS2, CP
29
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7.7NOS2, IL6, IL10, TNF, IFNG
30
Development PDGF signaling via STATs and NF-kB
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7.7NOS2, IL6, IL10, TNF, IFNG
317.7NOS2, IL6, IL10, TNF, IFNG
327.7IFNG, TNF, IL10, IL6, NOS2
33
Hide members
7.7IL6, IL4, IL10, TNF, IFNG
347.7IL6, IL4, IL10, TNF, IFNG
357.7TNF, TF, VEGFA, IL10, IL6

Compounds for genes affiliated with Eales Disease

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Eales Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6RBP3
2pentoxifylline44 1111.5IL4
3gabexate mesilate4410.4F5
4endotoxin4410.4F5
5diphenyleneiodonium4410.3SERPINF1, SOD1
6ivig4410.2IFNG, SAG
7triamcinolone acetonide44 2811.2TF, SERPINF1
8pge24410.2SAG, VEGFA
9tacrolimus44 49 1112.0IL4, IFNG
10cyclosporin a44 28 5911.8IFNG, SAG, TF
112,5-oligoadenylate449.7TNF
12dexamethasone44 49 28 1112.5IL6, SERPINF1, VEGFA
13pdtc449.4NOS2, SOD1, IL6, CP
14betaseron449.3IL4, IL10, IFNG
15s-nitroso-n-acetylpenicillamine449.3NOS2, CP, SOD1, IFNG
16citrulline44 2410.2IFNG, SOD1, IL10, NOS2
17gm-csf44 2810.1IL10, IFNG, TNF
18fluorescein44 1110.1F5, TF, VEGFA, SERPINF1
19apocynin44 599.8VEGFA, SOD1, TNF, NOS2
20cdp571448.7IL10, IL6, TNF
21interferon gamma448.7IL10, IL4, IFNG, TNF
22vesnarinone448.6TNF, NOS2, IFNG, IL6
23mip 1alpha448.5TNF, IL6, IL4, IL10
24parthenolide44 29.5IFNG, TNF, IL6, NOS2
25adalimumab44 49 1110.4IL6, TNF, IFNG, IL10
26imiquimod44 28 59 1111.3IL10, TNF, IFNG, IL6
278-isoprostane448.3SOD1, IL6, TF, IL10, TNF
28taurine chloramine448.3IL6, IFNG, F5, NOS2, TNF
29herbimycin a44 599.2IL4, TNF, NOS2, IFNG
30triptolide448.1TNF, IFNG, VEGFA, IL6, NOS2
31il-12448.1IFNG, IL6, TNF, IL10, IL4
32polymyxin b448.1IL6, IL10, TNF, IFNG, IL4
33okt3448.1IFNG, TNF, IL10, IL6, IL4
34il 10448.1IL6, IFNG, TNF, IL10, IL4
35neopterin448.0IL6, IL4, TNF, IFNG, IL10
36etanercept44 49 1110.0IFNG, TNF, IL10, IL6
37thalidomide44 49 59 1110.8IL6, IFNG, IL10, VEGFA, TNF
38atorvastatin44 49 28 11 2411.8TNF, F5, VEGFA, IL6, IL10
39polyinosinic-polycytidylic acid447.8IL10, IL6, TNF, NOS2, IL4, IFNG
40prostacyclin447.7NOS2, SOD1, IL10, VEGFA, F5, TF
41infliximab44 49 119.6IL4, IL10, VEGFA, TNF, IFNG, IL6
42histamine44 28 249.5TNF, IL6, IL4, IL10, TF, IFNG
43n acetylcysteine447.4SOD1, TNF, TF, IL4, IL6, NOS2
44actinomycin d447.3TNF, VEGFA, IL4, IL6, NOS2, IFNG
45ly294002447.3TNF, NOS2, IL6, IL4, IL10, VEGFA
4615-deoxy-delta-12,14-prostaglandin j2447.3IFNG, VEGFA, IL10, IL4, IL6, NOS2
47sb 20358044 598.2IFNG, TNF, VEGFA, IL6, NOS2, IL4
48simvastatin44 49 59 28 11 2412.2F5, VEGFA, IL10, IL4, IL6, TNF
49nitric oxide44 11 248.9RBP3, SOD1, IFNG, NOS2, TNF, IL10
50vegf445.9CP, IFNG, TNF, TF, F5, VEGFA

GO Terms for genes affiliated with Eales Disease

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Sources:
16Gene Ontology
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Cellular components related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2IL6, IL4, TNF, IFNG
2extracellular regionGO:0055765.9TF, TNF, SOD1, IFNG, RBP3, F5
3extracellular spaceGO:0056155.5CP, IFNG, SOD1, TNF, RBP3, F5

Biological processes related to Eales Disease according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.4IFNG
2innate immune response in mucosaGO:00222710.1IL4, NOS2
3positive regulation of killing of cells of other organismGO:05171210.1IFNG, NOS2
4regulation of isotype switchingGO:04519110.0IL10, IL4
5positive regulation of isotype switching to IgG isotypesGO:0483049.9IFNG, IL4
6type 2 immune responseGO:0420929.9IL10, IL4
7cellular iron ion homeostasisGO:0068799.9CP, TF, SOD1
8negative regulation of nitric oxide biosynthetic processGO:0450199.8IL4, IL10
9response to nutrient levelsGO:0316679.7IL6, SOD1
10muscle cell cellular homeostasisGO:0467169.6IL6, SOD1
11positive regulation of vitamin D biosynthetic processGO:0605579.6IFNG, TNF
12positive regulation of calcidiol 1-monooxygenase activityGO:0605599.6IFNG, TNF
13superoxide metabolic processGO:0068019.6NOS2, SOD1
14positive regulation of MHC class II biosynthetic processGO:0453489.5IFNG, IL10, IL4
15receptor biosynthetic processGO:0328009.5TNF, IL10
16negative regulation of cytokine secretion involved in immune responseGO:0027409.5TNF, IL10
17cellular response to lipopolysaccharideGO:0712229.4NOS2, IL10, IFNG
18defense response to protozoanGO:0428329.4IL6, IL4, IFNG
19positive regulation of T cell proliferationGO:0421029.4IFNG, IL4, IL6
20platelet degranulationGO:0025769.4SOD1, TF, F5, VEGFA
21positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IFNG, TNF
22defense response to bacteriumGO:0427429.3NOS2, IL10, IFNG
23epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.3TNF, IL6
24negative regulation of lipid storageGO:0108889.3TNF, IL6
25positive regulation of protein complex assemblyGO:0313349.2TNF, VEGFA
26positive regulation of chemokine biosynthetic processGO:0450809.2IL4, TNF, IFNG
27positive regulation of osteoclast differentiationGO:0456729.2IFNG, TNF
28regulation of insulin secretionGO:0507969.1NOS2, TNF, IFNG
29negative regulation of growth of symbiont in hostGO:0441309.1IL10, TNF, IFNG
30positive regulation of nitric oxide biosynthetic processGO:0454299.0IFNG, TNF, IL6
31blood coagulationGO:0075969.0NOS2, VEGFA, F5, TF, SOD1
32humoral immune responseGO:0069599.0IL6, TNF, IFNG
33positive regulation of chemokine productionGO:0327228.9TNF, IL6
34positive regulation of peptidyl-serine phosphorylationGO:0331388.8IL6, VEGFA, TNF
35response to glucocorticoid stimulusGO:0513848.8IL6, IL10, TNF
36platelet activationGO:0301688.8SOD1, TF, F5, VEGFA, IL6
37positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.5TNF, IL10, IL4, IL6
38inflammatory responseGO:0069548.4TNF, IL10, IL6, NOS2
39response to drugGO:0424937.9IL6, IL4, IL10, TNF, SOD1, IFNG
40positive regulation of transcription from RNA polymerase II promoterGO:0459447.6IL6, IL4, IL10, VEGFA, TNF, IFNG

Molecular functions related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5CP, F5, SOD1
2growth factor activityGO:0080838.1VEGFA, IL10, IL4, IL6
3cytokine activityGO:0051257.1IL6, IL4, IL10, VEGFA, TNF, IFNG

Products for genes affiliated with Eales Disease

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  • Antibodies
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Sources for Eales Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet