MCID: ELS001
MIFTS: 46

Eales Disease malady

Categories: Rare diseases, Eye diseases, Cardiovascular diseases

Aliases & Classifications for Eales Disease

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Sources:
30ICD10 via Orphanet, 39MESH via Orphanet, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Eales Disease:

Name: Eales Disease 47 53 49 67
Idiopathic Recurrent Vitreal Hemorrhage 47
Idiopathic Obliterative Vasculopathy 47
 
Idiopathic Retinal Perivasculitis 53
Idiopathic Retinal Vasculitis 53

Characteristics:

Orphanet epidemiological data:

53
eales disease:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy

Classifications:

Orphanet: 53 
Rare eye diseases


External Ids:

Orphanet53 ORPHA40923
MESH via Orphanet39 C538011
UMLS via Orphanet68 C0271073
ICD10 via Orphanet30 H35.0

Summaries for Eales Disease

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Wikipedia:70 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

MalaCards based summary: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to chorioretinitis and hypothyroidism. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1, Soluble), and among its related pathways are IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are craniofacial and muscle.

Related Diseases for Eales Disease

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Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 318)
idRelated DiseaseScoreTop Affiliating Genes
1chorioretinitis29.5IL6, TNF, VEGFA
2hypothyroidism29.1IL1B, IL6, TNF
3irvan syndrome11.5
4piepkorn karp hickok syndrome10.7IL10, TNF
5autoimmune pancreatitis10.6IFNG, TNF
6multiple system atrophy with orthostatic hypotension10.6CP, SOD1
7fallopian tube endometriosis10.6IL10, TNF
8primary systemic mycosis10.5IFNG, TNF
9graft-versus-host disease, protection against10.5IFNG, IL10, TNF
10addison's disease10.5IFNG, IL10, TNF
11hernia of ovary and fallopian tube10.5IFNG, IL10, TNF
12sensorineural hearing loss10.5IFNG, IL10, TNF
13granulomatous hypophysitis10.5CP, TNF
14psychologic dyspareunia10.5IFNG, IL10, TNF
15hypospadias10.5IFNG, IL10, TNF
16myoclonus epilepsy10.5IFNG, IL4
17subendocardial infarction acute myocardial infarction10.5IFNG, IL10, TNF
18bartter disease10.4IFNG, IL10, TNF
19potter's syndrome10.4IFNG, RBP3, TNF
20autoimmune thyroid disease 410.4IFNG, IL10, TNF
21motor peripheral neuropathy10.4IFNG, IL4
22uveoparotid fever10.4SERPINF1, TNF
23listeriosis10.4NOS2, SAG, SOD1
24nut allergy10.4IFNG, IL4
25vitamin metabolic disorder10.4CP, SOD1
26common wart10.4IL10, TF, TNF
27hepatitis b10.4IFNG, IL10, TNF
28epididymo-orchitis10.3IL10, IL4
29hyperthyroxinemia10.3TF, TNF
30distal monosomy 9p10.3IFNG, IL10, VEGFA
31stampe sorensen syndrome10.3IFNG, TNF, VEGFA
32predominantly cortical thymoma10.3IL10, IL6
33eye accommodation disease10.3IFNG, IL10, IL4
34aortic arch interruption10.3IL6, TNF
356q terminal deletion syndrome10.3IL10, IL4, TNF
36thelaziasis10.3IFNG, IL10, IL4
37emphysematous cholecystitis10.3NOS2, VEGFA
38buruli ulcer10.3IFNG, IL10, IL4
39basidiobolomycosis10.3IL10, IL4, TNF
40paralytic lagophthalmos10.3IL10, IL4, TNF
41neurotic excoriation10.3IL10, IL4, TNF
42peripheral t-cell lymphoma10.3IL10, IL4, TNF
43gonococcal synovitis10.3IFNG, IL4, TNF
44alkhurma hemorrhagic fever10.3IL10, IL4, TNF
45peanut allergy10.3IL10, IL4, TNF
46tetanus neonatorum10.3IFNG, IL10, IL4
47maligant granulosa cell tumor of ovary10.3IL6, TNF
48progressive relapsing multiple sclerosis10.3IFNG, IL10, IL4
49atrichia with papular lesions10.3IFNG, IL4, TNF
50hemometra10.3IL6, TNF

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Symptoms for Eales Disease

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Drugs & Therapeutics for Eales Disease

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Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RanibizumabapprovedPhase 2, Phase 3474347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
2Angiogenesis Modulating AgentsPhase 2, Phase 34072
3Angiogenesis InhibitorsPhase 2, Phase 34143

Interventional clinical trials:

idNameStatusNCT IDPhase
1Lucentis (Ranibizumab) for Eales' DiseaseCompletedNCT00384449Phase 2, Phase 3

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

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Anatomical Context for Eales Disease

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MalaCards organs/tissues related to Eales Disease:

35
Retina, Eye, Endothelial, Thyroid, Monocytes

Animal Models for Eales Disease or affiliated genes

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MGI Mouse Phenotypes related to Eales Disease:

40 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5IFNG, IL10, IL4, NOS2, TNF, VEGFA
2MP:00053698.3IFNG, IL10, IL6, NOS2, SOD1, TNF
3MP:00053888.0IFNG, IL10, IL4, IL6, NOS2, TNF
4MP:00020067.4IFNG, IL10, IL1B, IL6, NOS2, SOD1
5MP:00053707.3CP, IFNG, IL10, IL4, IL6, NOS2
6MP:00053847.3CP, IFNG, IL10, IL4, IL6, NOS2
7MP:00053797.2IFNG, IL10, IL4, IL6, NOS2, SERPINF1
8MP:00053897.2IFNG, IL10, IL4, IL6, NOS2, SERPINF1
9MP:00053817.1IFNG, IL10, IL4, IL6, NOS2, SERPINF1
10MP:00107716.8IFNG, IL10, IL1B, IL4, IL6, NOS2
11MP:00053906.3IFNG, IL10, IL1B, IL4, IL6, NOS2
12MP:00107686.3IFNG, IL10, IL1B, IL4, IL6, NOS2
13MP:00053916.1CP, IFNG, IL10, IL4, IL6, NOS2
14MP:00053855.9CP, IFNG, IL10, IL1B, IL6, NOS2
15MP:00053875.8CP, IFNG, IL10, IL1B, IL4, IL6
16MP:00053765.5CP, IFNG, IL10, IL1B, IL4, IL6
17MP:00053975.4CP, IFNG, IL10, IL1B, IL4, IL6
18MP:00036315.1CP, IFNG, IL10, IL1B, IL4, IL6

Publications for Eales Disease

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Articles related to Eales Disease:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? (26842710)
2016
2
Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease. (26807780)
2016
3
Ultra-wide field angiography in the management of Eales disease. (27609162)
2016
4
Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience. (25657155)
2015
5
Eales disease: no typical clinical presentation. (25374641)
2014
6
Surgical outcomes of minimally invasive vitrectomy surgery in Eales' disease. (24172552)
2013
7
Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales' disease. (23761385)
2013
8
Eales' disease with neurological complications. (24005742)
2013
9
Combination of intravitreal bevacizumab and peripheral photocoagulation: an alternative treatment in eales disease. (24600639)
2013
10
Eales' disease - current concepts in diagnosis and management. (23514227)
2013
11
The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease. (25390730)
2012
12
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. (22169980)
2012
13
Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease. (22486260)
2012
14
Vitreopapillary and vitreomacular traction in proliferative Eales' disease. (23109416)
2012
15
Eales disease associated with serpiginous choroiditis. (23143459)
2012
16
Case report: ampiginous chorioretinopathy associated with eales disease in a patient with presumed tuberculosis. (25390176)
2011
17
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. (21849807)
2011
18
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. (20720222)
2011
19
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. (21394064)
2011
20
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. (21301382)
2011
21
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. (20533927)
2010
22
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). (18936719)
2009
23
Spontaneous relief of vitreomacular traction and regression of neovascularization in eales disease after intravitreal injection of bevacizumab. (25391054)
2009
24
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. (18536597)
2008
25
Intravitreal injection of bevacizumab in Eales disease. (18379947)
2008
26
Eales' disease: oxidant stress and weak antioxidant defence. (17322597)
2007
27
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. (17392871)
2007
28
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. (17852192)
2007
29
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (17536031)
2007
30
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. (16980931)
2007
31
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. (16133465)
2006
32
Intravitreal triamcinolone acetonide in Eales disease. (16467685)
2006
33
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. (15283219)
2004
34
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. (15512947)
2004
35
Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy. (14632162)
2003
36
Osseous metaplasia in an epiretinal membrane in eales disease. (12441733)
2002
37
Eales disease--an update. (12052408)
2002
38
Mycobacterium tuberculosis infection complicated by Eales disease with peripheral neuropathy. (12355398)
2002
39
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. (12688097)
2002
40
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. (9873227)
1999
41
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. (10487964)
1999
42
Long term visual results of vitrectomy for Eales disease complications. (10090452)
1998
43
Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation. (9683168)
1998
44
Vitrectomy for complicated Eales disease. (11189322)
1997
45
Chronic encephalitis and Eales disease. (8326335)
1993
46
Visualization of retinal vasculitis in Eales' disease. (22827191)
1993
47
Eales disease with internuclear ophthalmoplegia. (1514745)
1992
48
Serum alpha-1 acid glycoprotein levels in patients with idiopathic peripheral retinal vasculitis (Eales' disease). (1414297)
1992
49
Unusual association of Eales disease with multifocal neurological deficit. (6530368)
1984
50
Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy, and malignant choroidal melanoma. (700971)
1978

Variations for Eales Disease

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Expression for genes affiliated with Eales Disease

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Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

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Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6IFNG, IL10, TNF
2
Show member pathways
9.5CP, NOS2, SOD1
39.4IFNG, IL10, IL4
49.4IFNG, IL10, IL4
59.2IFNG, IL6, NOS2
69.0IFNG, IL1B, NOS2
78.9CP, NOS2, TF, VEGFA
88.9IFNG, IL6, NOS2, TNF
98.8IL1B, IL6, SOD1
108.7IL1B, IL6, TNF
118.7IFNG, IL1B, NOS2, TNF
128.5IL1B, IL4, IL6
138.5IFNG, IL10, IL4, IL6, TNF
148.5IL10, IL1B, IL6, TNF
158.4IFNG, IL1B, IL6, TNF
16
Show member pathways
8.4IFNG, IL1B, IL4, NOS2
178.4IFNG, IL6, NOS2, TNF, VEGFA
188.4IFNG, IL6, NOS2, TF, VEGFA
198.4IL10, IL4, IL6, NOS2, TNF
20
Show member pathways
8.3IFNG, IL1B, IL6, NOS2
218.3IFNG, IL10, IL1B, IL4, TNF
228.3IFNG, IL10, IL1B, IL4, TNF
238.3IL1B, IL6, TNF, VEGFA
24
Show member pathways
8.2IFNG, IL1B, IL4, IL6
258.2IL1B, IL4, IL6, TNF
26
Show member pathways
8.2IFNG, IL10, IL1B, IL6, TNF
278.2IFNG, IL10, IL1B, IL6, TNF
288.2IFNG, IL10, IL1B, IL6, TNF
298.2IFNG, IL10, IL1B, IL6, TNF
308.1IL10, IL1B, IL6, NOS2, TNF
31
Show member pathways
8.0IFNG, IL1B, IL6, NOS2, TNF
328.0IFNG, IL1B, IL6, TNF, VEGFA
33
Show member pathways
8.0IFNG, IL10, IL1B, IL4, IL6
347.9IL10, IL1B, IL4, IL6, TNF
35
Show member pathways
7.9IFNG, IL1B, IL4, IL6, TNF
36
Show member pathways
7.9IFNG, IL10, IL1B, IL4, NOS2, TNF
37
Show member pathways
7.8IFNG, IL10, IL1B, IL6, NOS2, TNF
387.8IFNG, IL10, IL1B, IL6, NOS2, TNF
397.8IFNG, IL10, IL1B, IL6, NOS2, TNF
40
Show member pathways
7.8IFNG, IL10, IL1B, IL6, NOS2, TNF
417.7IL10, IL1B, IL6, TF, TNF, VEGFA
42
Show member pathways
7.7IFNG, IL10, IL1B, IL4, IL6, TNF
43
Show member pathways
7.7IFNG, IL10, IL1B, IL4, IL6, TNF
44
Show member pathways
7.7IFNG, IL10, IL1B, IL4, IL6, TNF
457.7IFNG, IL10, IL1B, IL4, IL6, TNF
46
Show member pathways
7.5IFNG, IL1B, IL4, IL6, NOS2, TNF
477.5IFNG, IL1B, IL4, IL6, NOS2, TNF
48
Show member pathways
6.3IFNG, IL10, IL1B, IL4, IL6, NOS2

GO Terms for genes affiliated with Eales Disease

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Cellular components related to Eales Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.5IL1B, SOD1, VEGFA
2external side of plasma membraneGO:00098978.9IFNG, IL4, IL6, TNF
3extracellular regionGO:00055765.9CP, IFNG, IL1B, IL6, RBP3, SERPINF1
4extracellular spaceGO:00056155.4CP, IFNG, IL10, IL1B, IL4, IL6

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1response to carbon monoxideGO:003446510.7IL10, SOD1
2receptor biosynthetic processGO:003280010.6IL10, TNF
3negative regulation of cytokine secretion involved in immune responseGO:000274010.6IL10, TNF
4positive regulation of vitamin D biosynthetic processGO:006055710.6IFNG, TNF
5positive regulation of killing of cells of other organismGO:005171210.5IFNG, NOS2
6regulation of isotype switchingGO:004519110.4IL10, IL4
7type 2 immune responseGO:004209210.4IL10, IL4
8positive regulation of mononuclear cell migrationGO:007167710.4IL4, TNF
9negative regulation of nitric oxide biosynthetic processGO:004501910.3IL10, IL4
10neutrophil apoptotic processGO:000178110.3IFNG, IL6
11positive regulation of isotype switching to IgG isotypesGO:004830410.3IFNG, IL4
12myeloid cell homeostasisGO:000226210.3IL6, SOD1
13epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
14negative regulation of growth of symbiont in hostGO:004413010.2IFNG, IL10, TNF
15negative regulation of lipid storageGO:001088810.1IL6, TNF
16cellular iron ion homeostasisGO:000687910.1CP, SOD1, TF
17positive regulation of interleukin-6 biosynthetic processGO:004541010.1IFNG, IL1B
18sequestering of triglycerideGO:003073010.1IL1B, TNF
19chronic inflammatory response to antigenic stimulusGO:000243910.1IL1B, TNF
20regulation of establishment of endothelial barrierGO:190314010.1IL1B, TNF
21positive regulation of MHC class II biosynthetic processGO:004534810.0IFNG, IL10, IL4
22positive regulation of cell adhesionGO:004578510.0IFNG, TNF, VEGFA
23positive regulation of heterotypic cell-cell adhesionGO:003411610.0IL1B, TNF
24positive regulation of fever generationGO:003162210.0IL1B, TNF
25humoral immune responseGO:00069599.9IFNG, IL6, TNF
26response to glucocorticoidGO:00513849.9IL10, IL6, TNF
27positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8IFNG, IL1B, TNF
28positive regulation of membrane protein ectodomain proteolysisGO:00510449.8IFNG, IL1B, TNF
29defense response to bacteriumGO:00427429.7IFNG, IL10, NOS2, TNF
30positive regulation of peptidyl-serine phosphorylationGO:00331389.4IL6, TNF, VEGFA
31defense response to protozoanGO:00428329.4IFNG, IL10, IL4, IL6
32positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4IL4, IL6, VEGFA
33negative regulation of gene expressionGO:00106299.3IFNG, NOS2, SERPINF1, TNF
34regulation of insulin secretionGO:00507969.3IFNG, IL1B, NOS2, TNF
35positive regulation of chemokine biosynthetic processGO:00450809.2IFNG, IL1B, IL4, TNF
36positive regulation of interleukin-6 productionGO:00327559.2IL1B, IL6, TNF
37cellular response to lipopolysaccharideGO:00712229.2IFNG, IL10, IL6, NOS2, TNF
38response to heatGO:00094089.0IL1B, IL6, SOD1
39positive regulation of protein phosphorylationGO:00019348.9IL1B, IL4, TNF, VEGFA
40positive regulation of nitric oxide biosynthetic processGO:00454298.8IFNG, IL1B, IL6, TNF
41response to lipopolysaccharideGO:00324968.8IL10, IL1B, IL6, NOS2
42positive regulation of T cell proliferationGO:00421028.7IFNG, IL1B, IL4, IL6
43negative regulation of apoptotic processGO:00430668.6IL10, IL4, IL6, SOD1, VEGFA
44positive regulation of apoptotic processGO:00430658.5IFNG, IL1B, IL6, SOD1, TNF
45positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.4IL10, IL1B, IL4, IL6, TNF
46response to drugGO:00424938.2IFNG, IL10, IL4, IL6, SOD1
47positive regulation of gene expressionGO:00106288.1IFNG, IL1B, IL6, TNF, VEGFA
48positive regulation of transcription, DNA-templatedGO:00458938.0IFNG, IL10, IL1B, IL4, IL6, TNF
49agingGO:00075687.8CP, IL10, IL1B, IL6, SERPINF1, SOD1
50positive regulation of transcription from RNA polymerase II promoterGO:00459447.2IFNG, IL10, IL1B, IL4, IL6, TNF

Molecular functions related to Eales Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.6IL10, IL4, IL6, VEGFA
2cytokine activityGO:00051256.9IFNG, IL10, IL1B, IL4, IL6, TNF

Sources for Eales Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet