MCID: ELS001
MIFTS: 46

Eales Disease

Categories: Rare diseases, Eye diseases, Cardiovascular diseases

Aliases & Classifications for Eales Disease

MalaCards integrated aliases for Eales Disease:

Name: Eales Disease 50 56 52 69
Idiopathic Recurrent Vitreal Hemorrhage 50
Idiopathic Obliterative Vasculopathy 50
Idiopathic Retinal Perivasculitis 56
Idiopathic Retinal Vasculitis 56

Characteristics:

Orphanet epidemiological data:

56
eales disease
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA40923
MESH via Orphanet 43 C538011
UMLS via Orphanet 70 C0271073
ICD10 via Orphanet 34 H35.0

Summaries for Eales Disease

NIH Rare Diseases : 50 eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards based summary : Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to choroiditis and irvan syndrome. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 72 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 307)
id Related Disease Score Top Affiliating Genes
1 choroiditis 28.9 IL10 IL1B IL6 TNF
2 irvan syndrome 11.9
3 pure autonomic failure 10.8 IL10 TNF
4 multiple familial trichoepithelioma 10.8 IL10 TNF
5 autoimmune polyglandular syndrome type 3 10.7 IFNG TNF
6 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
7 graft-versus-host disease, protection against 10.7 IFNG IL10
8 mosaic trisomy 1 10.7 IFNG TNF
9 dumping syndrome 10.6 IFNG IL10
10 endosalpingiosis 10.6 IL10 TNF
11 cardiac sarcoidosis 10.6 SERPINF1 TNF
12 primary systemic mycosis 10.6 IFNG TNF
13 plantar wart 10.6 IFNG IL10 TNF
14 psychologic dyspareunia 10.6 IFNG IL10 TNF
15 myoclonic astatic epilepsy 10.6 IFNG IL4
16 hypospadias 10.6 IFNG IL10 TNF
17 myoclonic encephalopathy of infants 10.6 CP SOD1
18 left bundle branch hemiblock 10.6 IFNG IL10 TNF
19 geniculate ganglionitis 10.5 IFNG IL10 TNF
20 low compliance bladder 10.5 NOS2 TNF
21 diabetic angiopathy 10.5 IL10 IL4
22 granulomatous rosacea 10.5 CP TNF
23 idiopathic dilatation of the pulmonary artery 10.5 IL10 NOS2 TNF
24 streptococcal meningitis 10.5 NOS2 SAG SOD1
25 smarca4-deficient sarcoma of thorax 10.4 IL6 TNF
26 distal monosomy 7q36 10.4 IFNG IL10 VEGFA
27 hepatitis b 10.4 IFNG IL10 TNF
28 retinitis pigmentosa 10.4 SOD1 TNF VEGFA
29 sparse hair ptosis mental retardation 10.4 IFNG TNF VEGFA
30 eye accommodation disease 10.4 IFNG IL10 IL4
31 aortic arch interruption 10.4 IL6 TNF
32 peroneal nerve paralysis 10.4 IL10 IL6
33 acute ackee fruit intoxication 10.4 IL10 IL4 TNF
34 thelaziasis 10.4 IFNG IL10 IL4
35 centronuclear myopathy 5 10.4 IFNG IL10 IL4
36 basidiobolomycosis 10.4 IL10 IL4 TNF
37 lagophthalmos 10.4 IL10 IL4 TNF
38 drug rash with eosinophilia and systemic symptoms 10.4 IL10 IL6
39 liver leiomyoma 10.4 IL10 IL4 TNF
40 segmental odontomaxillary dysplasia 10.4 TF TNF VEGFA
41 alkhurma hemorrhagic fever 10.4 IL10 IL4 TNF
42 loiasis 10.3 IFNG IL10 IL4
43 spirillary rat-bite fever 10.3 IL6 TNF
44 acute vascular insufficiency of intestine 10.3 IFNG IL4 TNF
45 deafness, autosomal recessive 22 10.3 IL10 IL4
46 pericardium disease 10.3 IL10 IL4 TNF
47 dehydration polycythemia 10.3 IL10 IL4 TNF
48 sublingual gland cancer 10.3 IL10 IL4 TNF
49 balkan nephropathy 10.3 IFNG IL10 IL4
50 pelvic varices 10.3 IL10 IL4 TNF

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to Eales Disease

Symptoms & Phenotypes for Eales Disease

MGI Mouse Phenotypes related to Eales Disease:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.29 IL1B IL4 IL6 NOS2 SERPINF1 SOD1
2 cardiovascular system MP:0005385 10.27 CP IFNG IL10 IL1B IL6 NOS2
3 homeostasis/metabolism MP:0005376 10.27 CP IFNG IL10 IL1B IL4 IL6
4 immune system MP:0005387 10.22 CP IFNG IL10 IL1B IL4 IL6
5 cellular MP:0005384 10.21 NOS2 SOD1 TNF VEGFA CP IFNG
6 endocrine/exocrine gland MP:0005379 10.18 SOD1 TNF VEGFA IFNG IL10 IL4
7 digestive/alimentary MP:0005381 10.14 TNF VEGFA IFNG IL10 IL4 IL6
8 nervous system MP:0003631 10.13 CP IFNG IL10 IL1B IL4 IL6
9 integument MP:0010771 10.11 IFNG IL10 IL1B IL4 IL6 NOS2
10 liver/biliary system MP:0005370 10.09 CP IFNG IL10 IL4 IL6 NOS2
11 craniofacial MP:0005382 10.02 IFNG IL10 IL4 NOS2 TNF VEGFA
12 neoplasm MP:0002006 9.97 IFNG IL10 IL1B IL6 NOS2 SOD1
13 muscle MP:0005369 9.95 IFNG IL10 IL6 NOS2 SOD1 TNF
14 reproductive system MP:0005389 9.91 IFNG IL10 IL4 IL6 NOS2 SERPINF1
15 respiratory system MP:0005388 9.7 IFNG IL10 IL4 IL6 NOS2 TNF
16 skeleton MP:0005390 9.65 IFNG IL10 IL1B IL4 IL6 NOS2
17 vision/eye MP:0005391 9.4 CP IFNG IL10 IL4 IL6 NOS2

Drugs & Therapeutics for Eales Disease

Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 2, Phase 3
3 Angiogenesis Modulating Agents Phase 2, Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

Anatomical Context for Eales Disease

MalaCards organs/tissues related to Eales Disease:

39
Retina, Eye, Endothelial, Thyroid, Monocytes

Publications for Eales Disease

Articles related to Eales Disease:

(show top 50) (show all 66)
id Title Authors Year
1
Long-Term Outcomes of a Large Cohort of Patients with Eales' Disease. ( 28448727 )
2017
2
Role of high-resolution computerized tomography chest in identifying tubercular etiology in patients diagnosed as Eales' disease. ( 28101723 )
2017
3
Detection of Mycobacterium tuberculosis with nested polymerase chain reaction analysis in enucleated eye ball in Eales' disease. ( 26499903 )
2016
4
Ultra-wide field angiography in the management of Eales disease. ( 27609162 )
2016
5
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? ( 26842710 )
2016
6
Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease. ( 26807780 )
2016
7
Eales Disease. ( 28586583 )
2016
8
Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience. ( 25657155 )
2015
9
Eales disease: no typical clinical presentation. ( 25374641 )
2014
10
Angiogenic potential of vitreous from proliferative diabetic retinopathy and eales' disease patients. ( 25310689 )
2014
11
Combination of intravitreal bevacizumab and peripheral photocoagulation: an alternative treatment in eales disease. ( 24600639 )
2013
12
Surgical outcomes of minimally invasive vitrectomy surgery in Eales' disease. ( 24172552 )
2013
13
Eales' disease with neurological complications. ( 24005742 )
2013
14
Profiling of human leukocyte antigens in Eales disease and tuberculosis. ( 23386050 )
2013
15
Eales' disease - current concepts in diagnosis and management. ( 23514227 )
2013
16
Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales' disease. ( 23761385 )
2013
17
Intravitreal bevacizumab as an adjunct to vitrectomy in advanced Eales' disease. ( 22089976 )
2012
18
The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease. ( 25390730 )
2012
19
Vitreopapillary and vitreomacular traction in proliferative Eales' disease. ( 23109416 )
2012
20
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. ( 23198627 )
2012
21
Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease. ( 24376904 )
2012
22
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. ( 22169980 )
2012
23
Eales disease associated with serpiginous choroiditis. ( 23143459 )
2012
24
Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease. ( 22486260 )
2012
25
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. ( 22025890 )
2011
26
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. ( 21301382 )
2011
27
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. ( 21849807 )
2011
28
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. ( 20720222 )
2011
29
Case report: ampiginous chorioretinopathy associated with eales disease in a patient with presumed tuberculosis. ( 25390176 )
2011
30
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. ( 21394064 )
2011
31
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. ( 20533927 )
2010
32
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). ( 18936719 )
2009
33
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. ( 20072643 )
2009
34
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. ( 19585364 )
2009
35
Spontaneous relief of vitreomacular traction and regression of neovascularization in eales disease after intravitreal injection of bevacizumab. ( 25391054 )
2009
36
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. ( 18536597 )
2008
37
Intravitreal injection of bevacizumab in Eales disease. ( 18379947 )
2008
38
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. ( 17852192 )
2007
39
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. ( 17392871 )
2007
40
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). ( 17536031 )
2007
41
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. ( 16980931 )
2007
42
Eales' disease: oxidant stress and weak antioxidant defence. ( 17322597 )
2007
43
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. ( 16133465 )
2006
44
Intravitreal triamcinolone acetonide in Eales disease. ( 16467685 )
2006
45
HLA typing in patients of Eales disease. ( 15907240 )
2005
46
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. ( 15512947 )
2004
47
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. ( 15283219 )
2004
48
Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy. ( 14632162 )
2003
49
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. ( 12849870 )
2003
50
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. ( 12688097 )
2002

Variations for Eales Disease

Expression for Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for Eales Disease

Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 IFNG IL10 IL1B IL4 IL6 NOS2
2
Show member pathways
13.52 IFNG IL10 IL1B IL4 IL6 TNF
3
Show member pathways
13.39 IFNG IL10 IL1B IL4 IL6 NOS2
4
Show member pathways
12.97 CP IL1B IL6 NOS2 TNF
5
Show member pathways
12.93 IFNG IL10 IL1B IL6 NOS2 TNF
6
Show member pathways
12.91 IFNG IL10 IL1B IL4 IL6 TNF
7
Show member pathways
12.82 IFNG IL1B IL4 IL6 TNF
8
Show member pathways
12.66 IFNG IL10 IL1B IL4 IL6 TNF
9
Show member pathways
12.65 IFNG IL10 IL1B IL6 NOS2 TNF
10 12.59 IFNG IL10 IL1B IL4 TNF
11
Show member pathways
12.5 IFNG IL10 IL1B IL4 IL6 TNF
12
Show member pathways
12.4 IFNG IL1B IL4 IL6 TNF
13
Show member pathways
12.34 IFNG IL1B IL6 NOS2 TNF
14
Show member pathways
12.32 IFNG IL10 IL1B IL4 NOS2 TNF
15 12.27 IFNG IL10 IL1B IL6 NOS2 TNF
16 12.26 IFNG IL6 NOS2 TNF VEGFA
17
Show member pathways
12.25 IFNG IL10 IL4 IL6
18
Show member pathways
12.22 IFNG IL1B IL4 IL6 NOS2 TNF
19 12.18 IL10 IL1B IL6 TF TNF VEGFA
20
Show member pathways
12.16 IFNG IL10 IL1B IL4 IL6 TNF
21 12.15 IFNG IL1B TNF VEGFA
22 12.08 IFNG IL10 IL4 IL6 TNF
23
Show member pathways
12.05 IFNG IL1B IL4 NOS2
24
Show member pathways
12.03 IFNG IL10 IL1B IL6 TNF
25
Show member pathways
11.99 IFNG IL1B IL4 IL6
26 11.98 IL1B IL6 TNF VEGFA
27 11.98 IFNG IL6 NOS2 TF VEGFA
28 11.97 IL1B IL4 IL6 TNF
29 11.96 IFNG IL1B IL4 IL6 NOS2 TNF
30 11.95 IL1B IL6 TNF
31 11.94 IFNG IL1B IL6
32 11.94 IFNG IL1B IL6 TNF VEGFA
33 11.91 IFNG IL1B IL6 NOS2
34 11.88 IFNG IL10 IL1B IL4 TNF
35 11.84 IL10 IL1B IL6 NOS2 TNF
36 11.83 IFNG IL10 IL1B IL6 TNF
37 11.82 IFNG IL4 IL6
38
Show member pathways
11.79 IFNG IL4 TNF
39 11.78 CP NOS2 TF VEGFA
40 11.78 IFNG IL10 IL1B IL6 NOS2 TNF
41 11.76 IL1B IL4 IL6 TNF
42 11.75 IL10 IL4 IL6 NOS2 TNF
43
Show member pathways
11.67 CP NOS2 SOD1
44 11.64 IFNG IL6 NOS2
45 11.64 IL1B IL6 TNF
46 11.62 IFNG IL1B NOS2 TNF
47 11.61 IL6 NOS2 VEGFA
48 11.6 IFNG IL6 TNF
49 11.58 IFNG IL1B TNF
50 11.58 IFNG IL1B IL6 TNF

GO Terms for Eales Disease

Cellular components related to Eales Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CP IFNG IL10 IL1B IL4 IL6
2 external side of plasma membrane GO:0009897 9.46 IFNG IL4 IL6 TNF
3 secretory granule GO:0030141 9.43 IL1B SOD1 VEGFA
4 extracellular space GO:0005615 9.4 CP IFNG IL10 IL1B IL4 IL6

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 IFNG IL4 IL6 VEGFA
2 defense response to bacterium GO:0042742 9.98 IFNG IL10 NOS2 TNF
3 response to drug GO:0042493 9.98 IFNG IL10 IL4 IL6 SOD1
4 negative regulation of gene expression GO:0010629 9.97 IFNG NOS2 SERPINF1 TNF
5 response to lipopolysaccharide GO:0032496 9.96 IL10 IL1B IL6 NOS2
6 aging GO:0007568 9.95 IL10 IL6 SERPINF1 SOD1
7 platelet degranulation GO:0002576 9.91 SOD1 TF VEGFA
8 activation of MAPK activity GO:0000187 9.9 IL1B SOD1 TNF
9 response to organic substance GO:0010033 9.89 IL10 SOD1 TNF
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 IL4 IL6 VEGFA
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 TNF VEGFA
12 response to glucocorticoid GO:0051384 9.87 IL10 IL6 TNF
13 cellular iron ion homeostasis GO:0006879 9.85 CP SOD1 TF
14 humoral immune response GO:0006959 9.84 IFNG IL6 TNF
15 positive regulation of cell adhesion GO:0045785 9.83 IFNG TNF VEGFA
16 positive regulation of protein phosphorylation GO:0001934 9.83 IFNG IL1B IL4 TNF VEGFA
17 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B IL6 TNF
18 regulation of insulin secretion GO:0050796 9.81 IFNG IL1B NOS2 TNF
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 IFNG IL4 IL6 VEGFA
20 positive regulation of T cell proliferation GO:0042102 9.78 IFNG IL1B IL4 IL6
21 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
22 negative regulation of nitric oxide biosynthetic process GO:0045019 9.73 IL10 IL4
23 positive regulation of chemokine production GO:0032722 9.73 IL6 TNF
24 positive regulation of protein complex assembly GO:0031334 9.73 IFNG TNF VEGFA
25 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.72 IL1B VEGFA
26 cellular response to hepatocyte growth factor stimulus GO:0035729 9.72 IL10 IL6
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
28 positive regulation of protein import into nucleus, translocation GO:0033160 9.72 IFNG IL6
29 cellular response to lipopolysaccharide GO:0071222 9.72 IFNG IL10 IL6 NOS2 TNF
30 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IFNG IL4
31 myeloid cell homeostasis GO:0002262 9.71 IL6 SOD1
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG IL1B TNF
33 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
34 regulation of defense response to virus by host GO:0050691 9.7 IFNG IL1B
35 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.7 IFNG IL1B
36 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
37 negative regulation of growth of symbiont in host GO:0044130 9.7 IFNG IL10 TNF
38 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
39 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
40 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
41 type 2 immune response GO:0042092 9.67 IL10 IL4
42 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IFNG IL1B IL6 TNF
43 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
44 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.65 IL10 IL1B IL4 IL6 TNF
45 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
46 positive regulation of killing of cells of other organism GO:0051712 9.63 IFNG NOS2
47 regulation of isotype switching GO:0045191 9.63 IL10 IL4
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
49 positive regulation of mononuclear cell migration GO:0071677 9.62 IL4 TNF
50 receptor biosynthetic process GO:0032800 9.61 IL10 TNF

Molecular functions related to Eales Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL10 IL4 IL6 VEGFA
2 cytokine activity GO:0005125 9.17 IFNG IL10 IL1B IL4 IL6 TNF

Sources for Eales Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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