MCID: ELS001
MIFTS: 47

Eales Disease malady

Eye, Cardiovascular categories

Summaries for Eales Disease

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinal vasculitis and vasculitis. An important gene associated with Eales Disease is SAG (S-antigen; retina and pineal gland (arrestin)), and among its related pathways are PEDF Induced Signaling and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cycloheximide and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include retina, thyroid and monocytes, and related mouse phenotypes are muscle and reproductive system.

Wikipedia:64 Eales disease, also known as angiopathia retinae juvenilis, periphlebitis retinae, primary... more...

Aliases & Classifications for Eales Disease

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Cardiovascular


Characteristics (Orphanet epidemiological data):

49
eales disease:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

eales disease 43 45 49 61
idiopathic recurrent vitreal hemorrhage 43
idiopathic obliterative vasculopathy 43


External Ids:

MESH via Orphanet36 C538011
ICD10 via Orphanet26 H35.0
SNOMED-CT via Orphanet58 54122009
UMLS via Orphanet62 C0271073

Related Diseases for Eales Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Clinical Features for Eales Disease

Drugs & Therapeutics for Eales Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eales Disease

Drug clinical trials:

Search ClinicalTrials for Eales Disease

Search NIH Clinical Center for Eales Disease

Search CenterWatch for Eales Disease

Genetic Tests for Eales Disease

Anatomical Context for Eales Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Eales Disease:

33
Retina, Thyroid, Monocytes, Endothelial

Animal Models for Eales Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Eales Disease:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.3SOD1
2MP:00053899.9VEGFA, SERPINF1
3MP:00107719.6IL6, VEGFA
4MP:00053889.5IL6, VEGFA
5MP:00053919.5SAG, SOD1, SERPINF1, RBP3, CP
6MP:00053909.2IL4, IL6, VEGFA
7MP:00036318.7SERPINF1, SAG, NOS2, F5, RBP3, SOD1
8MP:00053768.6F5, IFNG, SOD1, TF, IL4, CP
9MP:00053858.6SERPINF1, NOS2, IL10, SOD1, CP, IFNG
10MP:00053798.2IL6, TNF, IL4, SERPINF1, IFNG
11MP:00020067.7IL10, IL6, TNF, IFNG, NOS2
12MP:00053827.4IL4, IL10, VEGFA, IFNG, NOS2, TNF
13MP:00053816.8SERPINF1, IL6, IL4, IL10, VEGFA, TNF
14MP:00053866.4VEGFA, F5, CP, NOS2, IL6, TNF
15MP:00053876.4SOD1, VEGFA, TNF, IFNG, IL6, NOS2
16MP:00053976.2IL4, IL10, VEGFA, NOS2, TF, SOD1
17MP:00053706.2SOD1, F5, IL6, CP, NOS2, IL4
18MP:00053846.2CP, TNF, IFNG, VEGFA, IL10, IL4
19MP:00107685.9NOS2, IL6, IL10, VEGFA, TF, IL4
20MP:00053785.8IL6, F5, TF, TNF, IFNG, IL4

Publications for Eales Disease

Sources:
51PubMed
See all sources

Articles related to Eales Disease:

(show all 45)
idTitleAuthorsYear
1
Profiling of human leukocyte antigens in Eales disease and tuberculosis. (23386050)
2013
2
Eales disease associated with serpiginous choroiditis. (23143459)
2012
3
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. (22169980)
2012
4
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. (23198627)
2012
5
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. (21849807)
2011
6
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. (20720222)
2011
7
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. (22025890)
2011
8
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. (21394064)
2011
9
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. (21301382)
2011
10
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. (20533927)
2010
11
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. (20072643)
2009
12
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. (19585364)
2009
13
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). (18936719)
2009
14
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. (18536597)
2008
15
Intravitreal injection of bevacizumab in Eales disease. (18379947)
2008
16
Eales' disease: oxidant stress and weak antioxidant defence. (17322597)
2007
17
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (17536031)
2007
18
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. (17392871)
2007
19
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. (17852192)
2007
20
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. (16980931)
2007
21
Intravitreal triamcinolone acetonide in Eales disease. (16467685)
2006
22
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. (16133465)
2006
23
HLA typing in patients of Eales disease. (15907240)
2005
24
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. (15283219)
2004
25
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. (15512947)
2004
26
Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy. (14632162)
2003
27
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. (12849870)
2003
28
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. (12688097)
2002
29
Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (12386081)
2002
30
Osseous metaplasia in an epiretinal membrane in eales disease. (12441733)
2002
31
Eales disease--an update. (12052408)
2002
32
Mycobacterium tuberculosis infection complicated by Eales disease with peripheral neuropathy. (12355398)
2002
33
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. (9873227)
1999
34
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. (10487964)
1999
35
Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation. (9683168)
1998
36
Long term visual results of vitrectomy for Eales disease complications. (10090452)
1998
37
Vitrectomy for complicated Eales disease. (11189322)
1997
38
Chronic encephalitis and Eales disease. (8326335)
1993
39
Visualization of retinal vasculitis in Eales' disease. (22827191)
1993
40
Eales' disease with progressive spastic paraparesis. (8226608)
1993
41
Eales disease with internuclear ophthalmoplegia. (1514745)
1992
42
Serum alpha-1 acid glycoprotein levels in patients with idiopathic peripheral retinal vasculitis (Eales' disease). (1414297)
1992
43
Unusual association of Eales disease with multifocal neurological deficit. (6530368)
1984
44
Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy, and malignant choroidal melanoma. (700971)
1978
45
ACQUIRED ACANTHOCYTOSIS AND MYELOPHTHISIS IN A CASE OF EALES'S DISEASE. (14188350)
1963

Genetic Variations for Eales Disease

Expression for genes affiliated with Eales Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

Sources:
52QIAGEN, 53R&D Systems, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Eales Disease according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SERPINF1
210.1IL4
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.0IFNG
4
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9.9IL6
5
Hide members
9.6IFNG, IL4
6
CFTR folding and maturation (norm and CF)
9.6CP, NOS2, SOD1
79.1IL10, IFNG, IL4
89.1IL4, IFNG, IL10
99.1IFNG, NOS2, IL6
109.0IFNG, IL4, IL6
119.0TF, VEGFA, NOS2, CP
129.0IL10, IL6, NOS2
13
Hide members
9.0VEGFA, SOD1, F5, TF
14
Hide members
9.0TF, F5, VEGFA, SOD1
15
Hide members
8.8IFNG, TNF, IL4
16
Hide members
8.7IFNG, TNF, IL10
178.7TNF, IL4, IL6
188.5IL10, TNF, IL6
198.3TNF, SOD1, IFNG, IL6
208.3TNF, IL4, IL6, NOS2
21
Hide members
8.3IL4, VEGFA, TNF, IFNG
228.2TNF, NOS2, IFNG, IL6
23
Immune response Bacterial infections in normal airways
8.2TNF, IFNG, IL6, NOS2
248.2NOS2, IFNG, TF, VEGFA, IL6
25
Hide members
8.2IL6, IL4, TNF, IFNG
26
Hide members
8.1TNF, IL6, IL10, IFNG
278.1IFNG, IL6, TNF, IL10
28
Hide members
7.9TNF, IFNG, NOS2, CP, IL6
29
Hide members
7.7NOS2, IL6, IL10, IFNG, TNF
307.7IFNG, NOS2, TNF, IL10, IL6
317.7TNF, IFNG, IL10, NOS2, IL6
32
Development PDGF signaling via STATs and NF-kB
Hide members
7.7IFNG, TNF, NOS2, IL6, IL10
33
Hide members
7.7IFNG, TNF, IL10, IL4, IL6
347.7TNF, IL10, IL4, IL6, IFNG
357.7VEGFA, IL10, TF, TNF, IL6

Compounds for genes affiliated with Eales Disease

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Eales Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6RBP3
2pentoxifylline45 1111.5IL4
3gabexate mesilate4510.4F5
4endotoxin4510.4F5
5diphenyleneiodonium4510.3SERPINF1, SOD1
6ivig4510.2IFNG, SAG
7triamcinolone acetonide45 2911.2TF, SERPINF1
8pge24510.2SAG, VEGFA
9tacrolimus45 50 1112.0IL4, IFNG
10cyclosporin a45 29 6011.8IFNG, SAG, TF
112,5-oligoadenylate459.7TNF
12dexamethasone45 50 29 1112.5IL6, SERPINF1, VEGFA
13pdtc459.4NOS2, SOD1, IL6, CP
14betaseron459.3IL4, IL10, IFNG
15s-nitroso-n-acetylpenicillamine459.3NOS2, CP, SOD1, IFNG
16citrulline45 2410.2IFNG, SOD1, IL10, NOS2
17gm-csf45 2910.1IL10, IFNG, TNF
18fluorescein45 1110.1F5, TF, VEGFA, SERPINF1
19apocynin45 609.8VEGFA, SOD1, TNF, NOS2
20cdp571458.7IL10, IL6, TNF
21interferon gamma458.7IL10, IL4, IFNG, TNF
22vesnarinone458.6TNF, NOS2, IFNG, IL6
23mip 1alpha458.5TNF, IL6, IL4, IL10
24parthenolide45 29.5IFNG, TNF, IL6, NOS2
25adalimumab45 50 1110.4IL6, TNF, IFNG, IL10
26imiquimod45 29 60 1111.3IL10, TNF, IFNG, IL6
278-isoprostane458.3SOD1, IL6, TF, IL10, TNF
28taurine chloramine458.3IL6, IFNG, F5, NOS2, TNF
29herbimycin a45 609.2IL4, TNF, NOS2, IFNG
30triptolide458.1TNF, IFNG, VEGFA, IL6, NOS2
31il-12458.1IFNG, IL6, TNF, IL10, IL4
32polymyxin b458.1IL6, IL10, TNF, IFNG, IL4
33okt3458.1IFNG, TNF, IL10, IL6, IL4
34il 10458.1IL6, IFNG, TNF, IL10, IL4
35neopterin458.0IL6, IL4, TNF, IFNG, IL10
36etanercept45 50 1110.0IFNG, TNF, IL10, IL6
37thalidomide45 50 60 1110.8IL6, IFNG, IL10, VEGFA, TNF
38atorvastatin45 50 29 11 2411.8TNF, F5, VEGFA, IL6, IL10
39polyinosinic-polycytidylic acid457.8IL10, IL6, TNF, NOS2, IL4, IFNG
40prostacyclin457.7NOS2, SOD1, IL10, VEGFA, F5, TF
41infliximab45 50 119.6IL4, IL10, VEGFA, TNF, IFNG, IL6
42histamine45 29 249.5TNF, IL6, IL4, IL10, TF, IFNG
43n acetylcysteine457.4SOD1, TNF, TF, IL4, IL6, NOS2
44actinomycin d457.3TNF, VEGFA, IL4, IL6, NOS2, IFNG
45ly294002457.3TNF, NOS2, IL6, IL4, IL10, VEGFA
4615-deoxy-delta-12,14-prostaglandin j2457.3IFNG, VEGFA, IL10, IL4, IL6, NOS2
47sb 20358045 608.2IFNG, TNF, VEGFA, IL6, NOS2, IL4
48simvastatin45 50 60 29 11 2412.2F5, VEGFA, IL10, IL4, IL6, TNF
49nitric oxide45 11 248.9RBP3, SOD1, IFNG, NOS2, TNF, IL10
50vegf455.9CP, IFNG, TNF, TF, F5, VEGFA

GO Terms for genes affiliated with Eales Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2IL6, IL4, TNF, IFNG
2extracellular regionGO:0055765.9CP, IFNG, SERPINF1, IL6, VEGFA, F5
3extracellular spaceGO:0056155.5IL6, CP, IL4, IL10, VEGFA, F5

Biological processes related to Eales Disease according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.4IFNG
2innate immune response in mucosaGO:00222710.1IL4, NOS2
3positive regulation of killing of cells of other organismGO:05171210.1IFNG, NOS2
4regulation of isotype switchingGO:04519110.0IL10, IL4
5positive regulation of isotype switching to IgG isotypesGO:0483049.9IFNG, IL4
6type 2 immune responseGO:0420929.9IL10, IL4
7cellular iron ion homeostasisGO:0068799.9CP, TF, SOD1
8negative regulation of nitric oxide biosynthetic processGO:0450199.8IL4, IL10
9response to nutrient levelsGO:0316679.7IL6, SOD1
10muscle cell cellular homeostasisGO:0467169.6IL6, SOD1
11positive regulation of vitamin D biosynthetic processGO:0605579.6IFNG, TNF
12positive regulation of calcidiol 1-monooxygenase activityGO:0605599.6IFNG, TNF
13superoxide metabolic processGO:0068019.6NOS2, SOD1
14positive regulation of MHC class II biosynthetic processGO:0453489.5IFNG, IL10, IL4
15receptor biosynthetic processGO:0328009.5TNF, IL10
16negative regulation of cytokine secretion involved in immune responseGO:0027409.5TNF, IL10
17cellular response to lipopolysaccharideGO:0712229.4NOS2, IL10, IFNG
18defense response to protozoanGO:0428329.4IL6, IL4, IFNG
19positive regulation of T cell proliferationGO:0421029.4IFNG, IL4, IL6
20platelet degranulationGO:0025769.4SOD1, TF, F5, VEGFA
21positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IFNG, TNF
22defense response to bacteriumGO:0427429.3NOS2, IL10, IFNG
23epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.3TNF, IL6
24negative regulation of lipid storageGO:0108889.3TNF, IL6
25positive regulation of protein complex assemblyGO:0313349.2TNF, VEGFA
26positive regulation of chemokine biosynthetic processGO:0450809.2IL4, TNF, IFNG
27positive regulation of osteoclast differentiationGO:0456729.2IFNG, TNF
28regulation of insulin secretionGO:0507969.1NOS2, TNF, IFNG
29negative regulation of growth of symbiont in hostGO:0441309.1IL10, TNF, IFNG
30positive regulation of nitric oxide biosynthetic processGO:0454299.0IFNG, TNF, IL6
31blood coagulationGO:0075969.0NOS2, VEGFA, F5, TF, SOD1
32humoral immune responseGO:0069599.0IL6, TNF, IFNG
33positive regulation of chemokine productionGO:0327228.9TNF, IL6
34positive regulation of peptidyl-serine phosphorylationGO:0331388.8IL6, VEGFA, TNF
35response to glucocorticoid stimulusGO:0513848.8IL6, IL10, TNF
36platelet activationGO:0301688.8SOD1, TF, F5, VEGFA, IL6
37positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.5TNF, IL10, IL4, IL6
38inflammatory responseGO:0069548.4TNF, IL10, IL6, NOS2
39response to drugGO:0424937.9IL6, IL4, IL10, TNF, SOD1, IFNG
40positive regulation of transcription from RNA polymerase II promoterGO:0459447.6IL6, IL4, IL10, VEGFA, TNF, IFNG

Molecular functions related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5CP, F5, SOD1
2growth factor activityGO:0080838.1VEGFA, IL10, IL4, IL6
3cytokine activityGO:0051257.1IL6, IL4, IL10, VEGFA, TNF, IFNG

Products for genes affiliated with Eales Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eales Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet