MCID: ELS001
MIFTS: 48

Eales Disease malady

Rare diseases, Eye diseases, Cardiovascular diseases categories
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Summaries for Eales Disease

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NIH Rare Diseases:42 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards based summary: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinal vasculitis and proliferative diabetic retinopathy. An important gene associated with Eales Disease is SAG (S-antigen; retina and pineal gland (arrestin)), and among its related pathways are Mechanisms of CFTR activation by S nitrosoglutathione normal and CF and Selected targets of ESR1. The compounds dmpo-oh and randox have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are vision/eye and liver/biliary system.

Wikipedia:65 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Aliases & Classifications for Eales Disease

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Eales Disease, Aliases & Descriptions:

Name: Eales Disease 42 44 48 62
Idiopathic Recurrent Vitreal Hemorrhage 42 62
 
Idiopathic Obliterative Vasculopathy 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Cardiovascular diseases
Orphanet: 48 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

48
eales disease:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood; Age of death: Normal


External Ids:

MESH via Orphanet35 C538011
ICD10 via Orphanet26 H35.0
UMLS via Orphanet63 C0271073

Related Diseases for Eales Disease

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Diseases related to Eales Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis31.4SAG
2proliferative diabetic retinopathy30.7VEGFA, SERPINF1
3retinal detachment30.4VEGFA, SERPINF1
4diabetic retinopathy30.3VEGFA, SERPINF1, SOD1, SAG
5melanoma29.8VEGFA, SERPINF1, CP, SAG
6retinitis10.6
7vasculitis10.5
8aceruloplasminemia10.4CP
9retinopathy of prematurity10.4VEGFA
10retinal vascular occlusion10.4F5
11tuberculosis10.3
12endophthalmitis10.3VEGFA, SAG
13senile cataract10.3SOD1, SERPINF1
14spiradenoma10.2SERPINF1, SAG
15pneumoconiosis10.2SOD1, CP
16blindness10.2SERPINF1, VEGFA
17macular retinal edema10.2VEGFA, SERPINF1
18menkes disease10.2SOD1, CP
19retinal vascular disease10.2VEGFA, SERPINF1
20corneal neovascularization10.2VEGFA, SERPINF1
21diabetic macular edema10.2VEGFA, SERPINF1
22uveitis10.2SERPINF1, SAG
23choroiditis10.2
24endotheliitis10.2
25retinal vein occlusion10.2F5, VEGFA
26central retinal vein occlusion10.2F5, VEGFA
27ovarian hyperstimulation syndrome10.1F5, VEGFA
28hyperhomocysteinemia10.1F5, SOD1
29alcoholic liver cirrhosis10.1TF, SOD1
30hypochromic microcytic anemia10.1TF, CP
31huntington's disease10.1SOD1, CP
32retinal degeneration10.1SERPINF1, CP, SAG
33hemosiderosis10.1CP, TF
34cataract10.0SERPINF1, SOD1
35siderosis10.0CP, TF
36retinal ischemia10.0
37internuclear ophthalmoplegia10.0
38chorioretinitis10.0
39encephalitis10.0
40hypothyroidism10.0
41ischemia10.0
42malignant choroid melanoma10.0
43neuropathy10.0
44ophthalmoplegia10.0
45peripheral neuropathy10.0
46thyroiditis10.0
47serpiginous choroiditis10.0
48spastic paraparesis10.0
49spasticity10.0
50uremia10.0SOD1, TF

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Symptoms for Eales Disease

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Drugs & Therapeutics for Eales Disease

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Drug clinical trials:

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Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

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Anatomical Context for Eales Disease

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MalaCards organs/tissues related to Eales Disease:

32
Retina, Eye, Endothelial, Thyroid, Monocytes

Animal Models for Eales Disease or affiliated genes

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MGI Mouse Phenotypes related to Eales Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3SAG, SOD1, CP, SERPINF1, VEGFA
2MP:00053708.1VEGFA, CP, SOD1, F5
3MP:00053857.8VEGFA, SERPINF1, CP, SOD1, F5
4MP:00053767.6F5, SOD1, CP, VEGFA, TF
5MP:00036317.6VEGFA, SERPINF1, CP, SOD1, SAG, F5

Publications for Eales Disease

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Articles related to Eales Disease:

(show all 50)
idTitleAuthorsYear
1
Angiogenic potential of vitreous from proliferative diabetic retinopathy and eales' disease patients. (25310689)
2014
2
Eales disease: no typical clinical presentation. (25374641)
2014
3
Profiling of human leukocyte antigens in Eales disease and tuberculosis. (23386050)
2013
4
Combination of intravitreal bevacizumab and peripheral photocoagulation: an alternative treatment in eales disease. (24600639)
2013
5
Eales disease associated with serpiginous choroiditis. (23143459)
2012
6
The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease. (25390730)
2012
7
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. (22169980)
2012
8
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. (23198627)
2012
9
Case report: ampiginous chorioretinopathy associated with eales disease in a patient with presumed tuberculosis. (25390176)
2011
10
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. (21849807)
2011
11
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. (20720222)
2011
12
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. (22025890)
2011
13
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. (21394064)
2011
14
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. (21301382)
2011
15
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. (20533927)
2010
16
Spontaneous relief of vitreomacular traction and regression of neovascularization in eales disease after intravitreal injection of bevacizumab. (25391054)
2009
17
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. (20072643)
2009
18
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. (19585364)
2009
19
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). (18936719)
2009
20
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. (18536597)
2008
21
Intravitreal injection of bevacizumab in Eales disease. (18379947)
2008
22
Eales' disease: oxidant stress and weak antioxidant defence. (17322597)
2007
23
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (17536031)
2007
24
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. (17392871)
2007
25
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. (17852192)
2007
26
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. (16980931)
2007
27
Intravitreal triamcinolone acetonide in Eales disease. (16467685)
2006
28
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. (16133465)
2006
29
HLA typing in patients of Eales disease. (15907240)
2005
30
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. (15283219)
2004
31
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. (15512947)
2004
32
Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy. (14632162)
2003
33
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. (12849870)
2003
34
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. (12688097)
2002
35
Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (12386081)
2002
36
Osseous metaplasia in an epiretinal membrane in eales disease. (12441733)
2002
37
Eales disease--an update. (12052408)
2002
38
Mycobacterium tuberculosis infection complicated by Eales disease with peripheral neuropathy. (12355398)
2002
39
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. (9873227)
1999
40
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. (10487964)
1999
41
Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation. (9683168)
1998
42
Long term visual results of vitrectomy for Eales disease complications. (10090452)
1998
43
Vitrectomy for complicated Eales disease. (11189322)
1997
44
Chronic encephalitis and Eales disease. (8326335)
1993
45
Visualization of retinal vasculitis in Eales' disease. (22827191)
1993
46
Eales' disease with progressive spastic paraparesis. (8226608)
1993
47
Eales disease with internuclear ophthalmoplegia. (1514745)
1992
48
Serum alpha-1 acid glycoprotein levels in patients with idiopathic peripheral retinal vasculitis (Eales' disease). (1414297)
1992
49
Unusual association of Eales disease with multifocal neurological deficit. (6530368)
1984
50
Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy, and malignant choroidal melanoma. (700971)
1978

Variations for Eales Disease

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Expression for genes affiliated with Eales Disease

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Expression patterns in normal tissues for genes affiliated with Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

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Compounds for genes affiliated with Eales Disease

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB
See all sources

Compounds related to Eales Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1dmpo-oh449.9CP, SOD1
2randox449.9CP, SOD1
3verteporfin449.9VEGFA, SERPINF1
4dmpo449.8CP, SOD1
5thiobarbituric acid449.7CP, SOD1
6carnosine44 2410.7CP, SOD1
7sodium azide449.5CP, SOD1
8ferrozine449.5CP, TF
9ferrous ammonium sulfate449.5TF, CP
10diphenyleneiodonium449.5VEGFA, SERPINF1, SOD1
11desogestrel44 1110.5CP, F5
12apotransferrin449.4CP, TF
13ferric ammonium citrate449.4TF, CP
14malondialdehyde449.3CP, F5, SOD1
15uric acid44 2410.3SOD1, CP, F5
16vitamin-e449.3SOD1, F5, CP
17azide449.2SOD1, CP
18gestodene44 1110.2CP, F5
19suprofen44 1110.2TF, CP, SOD1
20fenton449.2TF, CP, SOD1
21dehydroascorbic acid44 1110.2SOD1, CP, TF
22dtpa449.2TF, SOD1, CP
23tocopherol449.1SOD1, CP, TF
24deferoxamine44 1110.1SOD1, CP, TF
25selenium44 2410.1SOD1, CP, TF
26triamcinolone acetonide44 2810.1VEGFA, SERPINF1, TF
27betacarotene449.1CP, SOD1, TF
28penicillin449.0F5, TF
29alpha tocopherol449.0SOD1, CP, TF
30sodium nitroprusside449.0SOD1, CP, TF
31vitamin b12448.9TF, F5, CP
32levodopa44 119.8TF, SAG, SOD1, CP
33vitamin a44 24 1110.8CP, SOD1, SAG, TF
34citrate448.8F5, TF, CP
35adenine44 24 1110.8F5, TF, CP
36cyclophosphamide44 50 1110.7TF, VEGFA, F5
37n acetylcysteine448.7TF, SOD1, SERPINF1, VEGFA
38folate448.6F5, TF, CP
39copper44 249.5SOD1, CP, TF, F5
40prostacyclin448.5VEGFA, TF, SOD1, F5
41ascorbic acid44 249.5F5, SOD1, CP, TF
42fluorescein44 119.5VEGFA, TF, SERPINF1, F5
43glutamine448.5F5, SAG, CP, TF
44aspartate448.4F5, TF, CP, SAG
45lactate448.4F5, TF, CP, SOD1
46creatinine448.4CP, TF, SOD1, F5
47heparin44 28 24 1111.4SAG, CP, SERPINF1, VEGFA, F5
48alanine448.1SOD1, SAG, F5, CP, TF
49vegf447.9SERPINF1, TF, F5, VEGFA, CP
50glutamate447.7F5, TF, SERPINF1, CP, SOD1, SAG

GO Terms for genes affiliated with Eales Disease

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Cellular components related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0F5, VEGFA
2extracellular vesicular exosomeGO:0700628.3SOD1, CP, SERPINF1, TF
3extracellular spaceGO:0056157.1F5, SOD1, CP, SERPINF1, VEGFA, TF
4extracellular regionGO:0055767.0TF, VEGFA, SERPINF1, CP, SOD1, F5

Biological processes related to Eales Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.5SERPINF1, VEGFA
2ovarian follicle developmentGO:0015419.2SOD1, VEGFA
3retina homeostasisGO:0018959.1TF, SOD1
4cellular iron ion homeostasisGO:0068798.8TF, CP, SOD1
5platelet degranulationGO:0025768.2F5, SOD1, VEGFA, TF
6platelet activationGO:0301688.2F5, SOD1, VEGFA, TF
7blood coagulationGO:0075968.1F5, SOD1, VEGFA, TF

Molecular functions related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone bindingGO:0510879.5SOD1, CP
2copper ion bindingGO:0055078.6F5, SOD1, CP

Products for genes affiliated with Eales Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Eales Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet