MCID: ELS001
MIFTS: 46

Eales Disease malady

Categories: Rare diseases, Eye diseases, Cardiovascular diseases

Aliases & Classifications for Eales Disease

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Sources:
31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Eales Disease:

Name: Eales Disease 48 54 50 68
Idiopathic Recurrent Vitreal Hemorrhage 48
Idiopathic Obliterative Vasculopathy 48
 
Idiopathic Retinal Perivasculitis 54
Idiopathic Retinal Vasculitis 54

Characteristics:

Orphanet epidemiological data:

54
eales disease:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Orphanet54 ORPHA40923
MESH via Orphanet40 C538011
UMLS via Orphanet69 C0271073
ICD10 via Orphanet31 H35.0

Summaries for Eales Disease

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NIH Rare Diseases:48 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. This condition is most common among young males and normally affects both eyes. In most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. Treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. Visual prognosis is good if treatment begins early in the course of the disease.  Last updated: 6/13/2011

MalaCards based summary: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to chorioretinitis and hypothyroidism. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1, Soluble), and among its related pathways are IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are craniofacial and muscle.

Wikipedia:71 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

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Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 318)
idRelated DiseaseScoreTop Affiliating Genes
1chorioretinitis29.5IL6, TNF, VEGFA
2hypothyroidism29.1IL1B, IL6, TNF
3irvan syndrome11.5
4piepkorn karp hickok syndrome10.7IL10, TNF
5autoimmune pancreatitis10.6IFNG, TNF
6multiple system atrophy with orthostatic hypotension10.6CP, SOD1
7fallopian tube endometriosis10.6IL10, TNF
8primary systemic mycosis10.5IFNG, TNF
9graft-versus-host disease, protection against10.5IFNG, IL10, TNF
10addison's disease10.5IFNG, IL10, TNF
11hernia of ovary and fallopian tube10.5IFNG, IL10, TNF
12sensorineural hearing loss10.5IFNG, IL10, TNF
13granulomatous hypophysitis10.5CP, TNF
14psychologic dyspareunia10.5IFNG, IL10, TNF
15hypospadias10.5IFNG, IL10, TNF
16myoclonus epilepsy10.5IFNG, IL4
17subendocardial infarction acute myocardial infarction10.5IFNG, IL10, TNF
18bartter disease10.4IFNG, IL10, TNF
19potter's syndrome10.4IFNG, RBP3, TNF
20autoimmune thyroid disease 410.4IFNG, IL10, TNF
21motor peripheral neuropathy10.4IFNG, IL4
22uveoparotid fever10.4SERPINF1, TNF
23listeriosis10.4NOS2, SAG, SOD1
24nut allergy10.4IFNG, IL4
25vitamin metabolic disorder10.4CP, SOD1
26common wart10.4IL10, TF, TNF
27hepatitis b10.4IFNG, IL10, TNF
28epididymo-orchitis10.3IL10, IL4
29hyperthyroxinemia10.3TF, TNF
30distal monosomy 9p10.3IFNG, IL10, VEGFA
31stampe sorensen syndrome10.3IFNG, TNF, VEGFA
32predominantly cortical thymoma10.3IL10, IL6
33eye accommodation disease10.3IFNG, IL10, IL4
34aortic arch interruption10.3IL6, TNF
356q terminal deletion syndrome10.3IL10, IL4, TNF
36thelaziasis10.3IFNG, IL10, IL4
37emphysematous cholecystitis10.3NOS2, VEGFA
38buruli ulcer10.3IFNG, IL10, IL4
39basidiobolomycosis10.3IL10, IL4, TNF
40paralytic lagophthalmos10.3IL10, IL4, TNF
41neurotic excoriation10.3IL10, IL4, TNF
42peripheral t-cell lymphoma10.3IL10, IL4, TNF
43gonococcal synovitis10.3IFNG, IL4, TNF
44alkhurma hemorrhagic fever10.3IL10, IL4, TNF
45peanut allergy10.3IL10, IL4, TNF
46tetanus neonatorum10.3IFNG, IL10, IL4
47maligant granulosa cell tumor of ovary10.3IL6, TNF
48progressive relapsing multiple sclerosis10.3IFNG, IL10, IL4
49atrichia with papular lesions10.3IFNG, IL4, TNF
50hemometra10.3IL6, TNF

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Symptoms & Phenotypes for Eales Disease

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MGI Mouse Phenotypes related to Eales Disease according to GeneCards Suite gene sharing:

41 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5IFNG, IL10, IL4, NOS2, TNF, VEGFA
2MP:00053698.3IFNG, IL10, IL6, NOS2, SOD1, TNF
3MP:00053888.0IFNG, IL10, IL4, IL6, NOS2, TNF
4MP:00020067.4IFNG, IL10, IL1B, IL6, NOS2, SOD1
5MP:00053707.3CP, IFNG, IL10, IL4, IL6, NOS2
6MP:00053847.3CP, IFNG, IL10, IL4, IL6, NOS2
7MP:00053797.2IFNG, IL10, IL4, IL6, NOS2, SERPINF1
8MP:00053897.2IFNG, IL10, IL4, IL6, NOS2, SERPINF1
9MP:00053817.1IFNG, IL10, IL4, IL6, NOS2, SERPINF1
10MP:00107716.8IFNG, IL10, IL1B, IL4, IL6, NOS2
11MP:00053906.3IFNG, IL10, IL1B, IL4, IL6, NOS2
12MP:00107686.3IFNG, IL10, IL1B, IL4, IL6, NOS2
13MP:00053916.1CP, IFNG, IL10, IL4, IL6, NOS2
14MP:00053855.9CP, IFNG, IL10, IL1B, IL6, NOS2
15MP:00053875.8CP, IFNG, IL10, IL1B, IL4, IL6
16MP:00053765.5CP, IFNG, IL10, IL1B, IL4, IL6
17MP:00053975.4CP, IFNG, IL10, IL1B, IL4, IL6
18MP:00036315.1CP, IFNG, IL10, IL1B, IL4, IL6

Drugs & Therapeutics for Eales Disease

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Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RanibizumabapprovedPhase 2, Phase 3474347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
2Angiogenesis Modulating AgentsPhase 2, Phase 34072
3Angiogenesis InhibitorsPhase 2, Phase 34143

Interventional clinical trials:

idNameStatusNCT IDPhase
1Lucentis (Ranibizumab) for Eales' DiseaseCompletedNCT00384449Phase 2, Phase 3

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

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Anatomical Context for Eales Disease

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MalaCards organs/tissues related to Eales Disease:

36
Retina, Eye, Endothelial, Thyroid, Monocytes

Publications for Eales Disease

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Articles related to Eales Disease:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? (26842710)
2016
2
Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease. (26807780)
2016
3
Ultra-wide field angiography in the management of Eales disease. (27609162)
2016
4
Detection of Mycobacterium tuberculosis with nested polymerase chain reaction analysis in enucleated eye ball in Eales' disease. (26499903)
2016
5
Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience. (25657155)
2015
6
Eales disease: no typical clinical presentation. (25374641)
2014
7
Angiogenic potential of vitreous from proliferative diabetic retinopathy and eales' disease patients. (25310689)
2014
8
Surgical outcomes of minimally invasive vitrectomy surgery in Eales' disease. (24172552)
2013
9
Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales' disease. (23761385)
2013
10
Eales' disease with neurological complications. (24005742)
2013
11
Combination of intravitreal bevacizumab and peripheral photocoagulation: an alternative treatment in eales disease. (24600639)
2013
12
Eales' disease - current concepts in diagnosis and management. (23514227)
2013
13
Profiling of human leukocyte antigens in Eales disease and tuberculosis. (23386050)
2013
14
The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease. (25390730)
2012
15
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. (22169980)
2012
16
Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease. (22486260)
2012
17
Vitreopapillary and vitreomacular traction in proliferative Eales' disease. (23109416)
2012
18
Eales disease associated with serpiginous choroiditis. (23143459)
2012
19
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. (23198627)
2012
20
Intravitreal bevacizumab as an adjunct to vitrectomy in advanced Eales' disease. (22089976)
2012
21
Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease. (24376904)
2012
22
Case report: ampiginous chorioretinopathy associated with eales disease in a patient with presumed tuberculosis. (25390176)
2011
23
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. (21849807)
2011
24
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. (20720222)
2011
25
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. (21394064)
2011
26
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. (21301382)
2011
27
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. (22025890)
2011
28
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. (20533927)
2010
29
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). (18936719)
2009
30
Spontaneous relief of vitreomacular traction and regression of neovascularization in eales disease after intravitreal injection of bevacizumab. (25391054)
2009
31
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. (20072643)
2009
32
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. (19585364)
2009
33
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. (18536597)
2008
34
Intravitreal injection of bevacizumab in Eales disease. (18379947)
2008
35
Eales' disease: oxidant stress and weak antioxidant defence. (17322597)
2007
36
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. (17392871)
2007
37
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. (17852192)
2007
38
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (17536031)
2007
39
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. (16980931)
2007
40
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. (16133465)
2006
41
Intravitreal triamcinolone acetonide in Eales disease. (16467685)
2006
42
HLA typing in patients of Eales disease. (15907240)
2005
43
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. (15283219)
2004
44
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. (15512947)
2004
45
Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy. (14632162)
2003
46
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. (12849870)
2003
47
Osseous metaplasia in an epiretinal membrane in eales disease. (12441733)
2002
48
Eales disease--an update. (12052408)
2002
49
Mycobacterium tuberculosis infection complicated by Eales disease with peripheral neuropathy. (12355398)
2002
50
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. (12688097)
2002

Variations for Eales Disease

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Expression for genes affiliated with Eales Disease

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Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

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Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6IFNG, IL10, TNF
2
Show member pathways
9.5CP, NOS2, SOD1
39.4IFNG, IL10, IL4
49.4IFNG, IL10, IL4
5
Show member pathways
9.4IFNG, IL4, TNF
69.4IL1B, TNF
79.3IFNG, IL10, IL6
89.2IFNG, IL6, NOS2
99.0IFNG, IL4, IL6
109.0IFNG, IL1B, NOS2
118.9CP, NOS2, TF, VEGFA
128.9IFNG, IL6, NOS2, TNF
138.8IL1B, IL6, SOD1
148.7IFNG, IL1B, IL6
158.7IL1B, IL6, TNF
168.7IL1B, IL6, TNF
178.7IFNG, IL1B, NOS2, TNF
188.5IL1B, IL4, IL6
198.5IFNG, IL10, IL4, IL6, TNF
208.5IL10, IL1B, IL6, TNF
218.4IFNG, IL1B, IL6, TNF
22
Show member pathways
8.4IFNG, IL1B, IL4, NOS2
238.4IFNG, IL6, NOS2, TNF, VEGFA
248.4IFNG, IL6, NOS2, TF, VEGFA
258.4IL10, IL4, IL6, NOS2, TNF
26
Show member pathways
8.3IFNG, IL1B, IL6, NOS2
278.3IFNG, IL10, IL1B, IL4, TNF
288.3IFNG, IL10, IL1B, IL4, TNF
298.3IL1B, IL6, TNF, VEGFA
30
Show member pathways
8.2IFNG, IL1B, IL4, IL6
318.2IL1B, IL4, IL6, TNF
32
Show member pathways
8.2IFNG, IL10, IL1B, IL6, TNF
338.2IFNG, IL10, IL1B, IL6, TNF
348.2IFNG, IL10, IL1B, IL6, TNF
358.2IFNG, IL10, IL1B, IL6, TNF
368.1IL10, IL1B, IL6, NOS2, TNF
37
Show member pathways
8.0IFNG, IL1B, IL6, NOS2, TNF
388.0IFNG, IL1B, IL6, TNF, VEGFA
39
Show member pathways
8.0IFNG, IL10, IL1B, IL4, IL6
40
Show member pathways
7.9CP, IL1B, IL6, NOS2, TNF
417.9IL10, IL1B, IL4, IL6, TNF
42
Show member pathways
7.9IFNG, IL1B, IL4, IL6, TNF
43
Show member pathways
7.9IFNG, IL10, IL1B, IL4, NOS2, TNF
447.8IFNG, IL10, IL1B, IL6, NOS2, TNF
457.8IFNG, IL10, IL1B, IL6, NOS2, TNF
46
Show member pathways
7.8IFNG, IL10, IL1B, IL6, NOS2, TNF
47
Show member pathways
7.8IFNG, IL10, IL1B, IL6, NOS2, TNF
487.7IL10, IL1B, IL6, TF, TNF, VEGFA
49
Show member pathways
7.7IFNG, IL10, IL1B, IL4, IL6, TNF
50
Show member pathways
7.7IFNG, IL10, IL1B, IL4, IL6, TNF

GO Terms for genes affiliated with Eales Disease

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Cellular components related to Eales Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.5IFNG, IL4, IL6, TNF
2secretory granuleGO:00301419.0IL1B, SOD1, VEGFA
3extracellular regionGO:00055766.9CP, IFNG, IL1B, IL6, RBP3, SERPINF1
4extracellular spaceGO:00056155.9CP, IFNG, IL10, IL1B, IL4, IL6

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:000274010.7IL10, TNF
2response to carbon monoxideGO:003446510.6IL10, SOD1
3receptor biosynthetic processGO:003280010.6IL10, TNF
4positive regulation of vitamin D biosynthetic processGO:006055710.6IFNG, TNF
5positive regulation of killing of cells of other organismGO:005171210.5IFNG, NOS2
6negative regulation of nitric oxide biosynthetic processGO:004501910.5IL10, IL4
7positive regulation of isotype switching to IgG isotypesGO:004830410.4IFNG, IL4
8positive regulation of mononuclear cell migrationGO:007167710.4IL4, TNF
9negative regulation of growth of symbiont in hostGO:004413010.4IFNG, IL10, TNF
10myeloid cell homeostasisGO:000226210.4IL6, SOD1
11cellular response to hepatocyte growth factor stimulusGO:003572910.4IL10, IL6
12regulation of isotype switchingGO:004519110.4IL10, IL4
13neutrophil apoptotic processGO:000178110.3IFNG, IL6
14epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
15negative regulation of lipid storageGO:001088810.3IL6, TNF
16cellular iron ion homeostasisGO:000687910.3CP, SOD1, TF
17platelet degranulationGO:000257610.2SOD1, TF, VEGFA
18positive regulation of cell adhesionGO:004578510.2IFNG, TNF, VEGFA
19positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL10, IL4
20chronic inflammatory response to antigenic stimulusGO:000243910.1IL1B, TNF
21positive regulation of interleukin-6 biosynthetic processGO:004541010.1IFNG, IL1B
22negative regulation of lipid catabolic processGO:005099510.1IL1B, TNF
23positive regulation of fever generationGO:003162210.1IL1B, TNF
24positive regulation of heterotypic cell-cell adhesionGO:003411610.1IL1B, TNF
25humoral immune responseGO:000695910.1IFNG, IL6, TNF
26regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
27regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
28defense response to bacteriumGO:004274210.0IFNG, IL10, NOS2, TNF
29response to glucocorticoidGO:00513849.9IL10, IL6, TNF
30activation of MAPK activityGO:00001879.9IL1B, SOD1, TNF
31response to organic substanceGO:00100339.9IL10, SOD1, TNF
32positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.9IL1B, VEGFA
33positive regulation of peptidyl-serine phosphorylationGO:00331389.9IL6, TNF, VEGFA
34positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8IFNG, IL1B, TNF
35positive regulation of membrane protein ectodomain proteolysisGO:00510449.8IFNG, IL1B, TNF
36negative regulation of gene expressionGO:00106299.7IFNG, NOS2, SERPINF1, TNF
37type 2 immune responseGO:00420929.7IL10, IL4
38positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6IL4, IL6, VEGFA
39defense response to protozoanGO:00428329.6IFNG, IL10, IL4, IL6
40positive regulation of interleukin-6 productionGO:00327559.5IL1B, IL6, TNF
41sequestering of triglycerideGO:00307309.5IL1B, TNF
42response to heatGO:00094089.4IL1B, IL6, SOD1
43cellular response to lipopolysaccharideGO:00712229.4IFNG, IL10, IL6, NOS2, TNF
44regulation of insulin secretionGO:00507969.3IFNG, IL1B, NOS2, TNF
45positive regulation of chemokine biosynthetic processGO:00450809.3IFNG, IL1B, IL4, TNF
46positive regulation of nitric oxide biosynthetic processGO:00454299.2IFNG, IL1B, IL6, TNF
47response to drugGO:00424939.2IFNG, IL10, IL4, IL6, SOD1
48negative regulation of apoptotic processGO:00430669.1IL10, IL4, IL6, SOD1, VEGFA
49positive regulation of protein phosphorylationGO:00019349.1IL1B, IL4, TNF, VEGFA
50positive regulation of T cell proliferationGO:00421029.0IFNG, IL1B, IL4, IL6

Molecular functions related to Eales Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.6IL10, IL4, IL6, VEGFA
2cytokine activityGO:00051257.8IFNG, IL10, IL1B, IL4, IL6, TNF

Sources for Eales Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet