MCID: ELS001
MIFTS: 50

Eales Disease malady

Categories: Rare diseases, Eye diseases, Cardiovascular diseases

Aliases & Classifications for Eales Disease

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Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Eales Disease:

Name: Eales Disease 45 47 51 65
Idiopathic Recurrent Vitreal Hemorrhage 45
Idiopathic Obliterative Vasculopathy 45
 
Idiopathic Retinal Perivasculitis 51
Idiopathic Retinal Vasculitis 51

Characteristics:

Orphanet epidemiological data:

51
eales disease:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Orphanet51 40923
ICD10 via Orphanet28 H35.0
MESH via Orphanet37 C538011
UMLS via Orphanet66 C0271073
UMLS65 C0271073

Summaries for Eales Disease

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NIH Rare Diseases:45 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards based summary: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to irvan syndrome and autoimmune oophoritis. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1, Soluble), and among its related pathways are MSP-RON Signaling and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include retina, eye and liver, and related mouse phenotypes are tumorigenesis and muscle.

Wikipedia:68 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

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Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1irvan syndrome11.8
2autoimmune oophoritis10.7IFNG, TNF
3non-distal monosomy 10q10.7IFNG, TNF
4ethmoid sinus squamous cell carcinoma10.7IFNG, TNF
5parasitic ichthyosporea infectious disease10.7IFNG, TNF
6hair defect with photosensitivity and mental retardation10.6TF, TNF
7warty dyskeratoma10.6TF, TNF
8cerebral sarcoidosis10.6SERPINF1, TNF
9plantar nerve lesion10.6IL6, TNF
10intermediate dend syndrome10.6IL6, TNF
11crohn's disease10.6IL6, TNF
12malignant sertoli-leydig cell tumor of ovary10.6IL6, TNF
13atrichia with papular lesions10.5IFNG, TNF
14mammary paget's disease10.5IL6, TNF
15lujo hemorrhagic fever10.5IL6, TNF
16posterior valve urethra10.5IL6, TNF
17cryptosporidiosis10.5IFNG, TF, TNF
18t cell immunodeficiency primary10.5IL6, TNF
19residual stage angle-closure glaucoma10.4IL6, TNF
20legionellosis10.4IFNG, NOS2, SOD1
21limbic encephalitis with ncmags antibodies10.4IFNG, IL4
22paranoid schizophrenia10.4IL6, TNF
23granulomas, congenital cerebral10.4CP, TNF
24progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome10.4CP, IFNG
25ischemic optic neuropathy10.4IL6, TNF
26fatal infantile encephalocardiomyopathy10.3CP, SOD1
27parovarian cyst10.3IL6, TF, TNF
28pityriasis rosea10.3RBP3, SAG
29conventional malignant hemangiopericytoma10.3IFNG, IL6, TNF
30motion sickness10.3IFNG, IL6, TNF
31retinitis10.3
32gonococcal bursitis10.3IFNG, IL4, TNF
33chronic lymphocytic leukemia10.3IL6, SOD1, TF
34epidermolysis bullosa dystrophica10.3IL6, TF, TNF
35soft palate cancer10.3IFNG, IL4, TNF
36hepatoid adenocarcinoma10.3IFNG, IL4, TNF
37spinal muscular atrophy10.3IL6, NOS2, TNF
38listeria meningitis10.3NOS2, SAG, SOD1
39reflex sympathetic dystrophy10.3IFNG, IL4, TNF
40punctate palmoplantar keratoderma type 210.3IL10, TNF
41leukoplakia of penis10.3IFNG, IL4, TNF
42cri-du-chat syndrome10.2RBP3, SAG, TNF
43congenital dyserythropoietic anemia10.2IFNG, IL6
44autosomal recessive type iv ehlers-danlos syndrome10.2IFNG, SERPINF1
45multifocal lymphangioendotheliomatosis with thrombocytopenia10.2IL10, TNF
46retinal vasculitis10.2
47vasculitis10.2
48cognitive impairment with or without cerebellar ataxia10.2CP, TF
49alternating exotropia10.2IL10, TNF
50tuberculosis10.2

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Symptoms for Eales Disease

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Drugs & Therapeutics for Eales Disease

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Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RanibizumabapprovedPhase 2, Phase 3460347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
2Immunologic FactorsPhase 2, Phase 318483
3Angiogenesis Modulating AgentsPhase 2, Phase 33611
4Angiogenesis InhibitorsPhase 2, Phase 33688

Interventional clinical trials:

idNameStatusNCT IDPhase
1Lucentis (Ranibizumab) for Eales' DiseaseCompletedNCT00384449Phase 2, Phase 3

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

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Anatomical Context for Eales Disease

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MalaCards organs/tissues related to Eales Disease:

33
Retina, Eye, Liver, Thyroid, Bone, T cells, Breast

Animal Models for Eales Disease or affiliated genes

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MGI Mouse Phenotypes related to Eales Disease:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IFNG, IL10, IL6, NOS2, SOD1, TNF
2MP:00053698.1IFNG, IL10, IL6, NOS2, SOD1, TNF
3MP:00053888.1IFNG, IL10, IL4, IL6, NOS2, TNF
4MP:00107717.9IFNG, IL10, IL4, IL6, NOS2, SOD1
5MP:00053817.6IFNG, IL10, IL4, IL6, NOS2, SERPINF1
6MP:00053797.5IFNG, IL10, IL4, IL6, NOS2, SERPINF1
7MP:00053897.4IFNG, IL10, IL4, IL6, NOS2, SERPINF1
8MP:00053707.3CP, IFNG, IL10, IL4, IL6, NOS2
9MP:00053847.1CP, IFNG, IL10, IL4, IL6, NOS2
10MP:00053907.1IFNG, IL10, IL4, IL6, NOS2, SERPINF1
11MP:00053857.0CP, IFNG, IL10, IL6, NOS2, SERPINF1
12MP:00053876.8CP, IFNG, IL10, IL4, IL6, NOS2
13MP:00053976.2CP, IFNG, IL10, IL4, IL6, NOS2
14MP:00053766.2CP, IFNG, IL10, IL4, IL6, NOS2
15MP:00053915.9CP, IFNG, IL10, IL4, IL6, NOS2
16MP:00036315.8CP, IFNG, IL10, IL4, IL6, NOS2

Publications for Eales Disease

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Articles related to Eales Disease:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease. (26807780)
2016
2
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? (26842710)
2016
3
Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience. (25657155)
2015
4
Angiogenic potential of vitreous from proliferative diabetic retinopathy and eales' disease patients. (25310689)
2014
5
Eales' disease - current concepts in diagnosis and management. (23514227)
2013
6
Surgical outcomes of minimally invasive vitrectomy surgery in Eales' disease. (24172552)
2013
7
Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales' disease. (23761385)
2013
8
Profiling of human leukocyte antigens in Eales disease and tuberculosis. (23386050)
2013
9
Eales' disease with neurological complications. (24005742)
2013
10
Eales disease associated with serpiginous choroiditis. (23143459)
2012
11
The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease. (25390730)
2012
12
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. (22169980)
2012
13
Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease. (22486260)
2012
14
Vitreopapillary and vitreomacular traction in proliferative Eales' disease. (23109416)
2012
15
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. (23198627)
2012
16
Intravitreal bevacizumab as an adjunct to vitrectomy in advanced Eales' disease. (22089976)
2012
17
Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease. (24376904)
2012
18
Case report: ampiginous chorioretinopathy associated with eales disease in a patient with presumed tuberculosis. (25390176)
2011
19
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. (21849807)
2011
20
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. (20720222)
2011
21
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. (22025890)
2011
22
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. (21394064)
2011
23
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. (20533927)
2010
24
Spontaneous relief of vitreomacular traction and regression of neovascularization in eales disease after intravitreal injection of bevacizumab. (25391054)
2009
25
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. (20072643)
2009
26
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. (19585364)
2009
27
Eales' disease: oxidant stress and weak antioxidant defence. (17322597)
2007
28
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (17536031)
2007
29
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. (17392871)
2007
30
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. (17852192)
2007
31
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. (16980931)
2007
32
Intravitreal triamcinolone acetonide in Eales disease. (16467685)
2006
33
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. (16133465)
2006
34
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. (15283219)
2004
35
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. (15512947)
2004
36
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. (12688097)
2002
37
Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (12386081)
2002
38
Osseous metaplasia in an epiretinal membrane in eales disease. (12441733)
2002
39
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. (9873227)
1999
40
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. (10487964)
1999
41
Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation. (9683168)
1998
42
Long term visual results of vitrectomy for Eales disease complications. (10090452)
1998
43
Vitrectomy for complicated Eales disease. (11189322)
1997
44
Chronic encephalitis and Eales disease. (8326335)
1993
45
Visualization of retinal vasculitis in Eales' disease. (22827191)
1993
46
Eales' disease with progressive spastic paraparesis. (8226608)
1993
47
Eales disease with internuclear ophthalmoplegia. (1514745)
1992
48
Serum alpha-1 acid glycoprotein levels in patients with idiopathic peripheral retinal vasculitis (Eales' disease). (1414297)
1992
49
Unusual association of Eales disease with multifocal neurological deficit. (6530368)
1984
50
Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy, and malignant choroidal melanoma. (700971)
1978

Variations for Eales Disease

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Expression for genes affiliated with Eales Disease

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Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

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Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathwaysScoreTop Affiliating Genes
19.5IFNG, NOS2, TNF
29.5IL4, IL6
39.4IFNG, IL6, TNF
49.4IFNG, IL6, TNF
59.4IFNG, IL6, NOS2
6
Show member pathways
9.4IFNG, IL6, NOS2
7
Show member pathways
9.4IFNG, IL4, TNF
8
Show member pathways
9.3IFNG, IL4, NOS2
9
Show member pathways
9.2CP, NOS2, SOD1
109.2IL4, IL6, TNF
119.2IFNG, IL4, IL6
12
Show member pathways
9.2IFNG, IL4, IL6
139.2CP, NOS2, TF
14
Show member pathways
9.2IFNG, IL6, SOD1, TNF
159.1IFNG, IL6, NOS2, TNF
169.1IFNG, IL6, NOS2, TNF
17
Show member pathways
9.1IFNG, IL6, NOS2, TNF
18
Show member pathways
9.1IFNG, IL10, TNF
199.1IFNG, IL6, NOS2, TF
208.9IL10, IL6, TNF
218.9IFNG, IL10, IL6
228.8IFNG, IL10, IL4
238.8IFNG, IL10, IL4
24
Show member pathways
8.6IFNG, IL10, IL6, TNF
258.6IFNG, IL10, IL6, TNF
268.6IFNG, IL10, IL6, TNF
278.6IFNG, IL10, IL6, TNF
288.6IL10, IL6, TF, TNF
298.6IL10, IL6, NOS2, TNF
30
Show member pathways
8.6IFNG, IL4, IL6, NOS2, TNF
318.6IFNG, IL4, IL6, NOS2, TNF
328.5IFNG, IL10, IL4, TNF
33
Show member pathways
8.4IFNG, IL10, IL4, IL6
348.3IFNG, IL10, IL6, NOS2, TNF
35
Show member pathways
8.3IFNG, IL10, IL6, NOS2, TNF
368.3IFNG, IL10, IL6, NOS2, TNF
37
Show member pathways
8.3IFNG, IL10, IL6, NOS2, TNF
38
Show member pathways
8.2IFNG, IL10, IL4, NOS2, TNF
398.1IFNG, IL10, IL4, IL6, TNF
40
Show member pathways
8.1IFNG, IL10, IL4, IL6, TNF
41
Show member pathways
8.1IFNG, IL10, IL4, IL6, TNF
428.1IFNG, IL10, IL4, IL6, TNF
43
Show member pathways
8.1IFNG, IL10, IL4, IL6, TNF
448.0IL10, IL4, IL6, NOS2, TNF
45
Show member pathways
7.3IFNG, IL10, IL4, IL6, NOS2, SERPINF1

GO Terms for genes affiliated with Eales Disease

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Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IFNG, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.6IFNG, TNF
3retina homeostasisGO:000189510.5SOD1, TF
4neutrophil apoptotic processGO:000178110.4IFNG, IL6
5epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
6positive regulation of cytokine productionGO:000181910.4SOD1, TNF
7protein import into nucleus, translocationGO:000006010.4IFNG, TNF
8response to antibioticGO:004667710.4IL6, SOD1
9myeloid cell homeostasisGO:000226210.4IL6, SOD1
10positive regulation of mononuclear cell migrationGO:007167710.4IL4, TNF
11negative regulation of lipid storageGO:001088810.3IL6, TNF
12positive regulation of osteoclast differentiationGO:004567210.3IFNG, TNF
13positive regulation of T cell proliferationGO:004210210.2IFNG, IL4
14positive regulation of isotype switching to IgG isotypesGO:004830410.2IFNG, IL4
15superoxide metabolic processGO:000680110.1NOS2, SOD1
16receptor biosynthetic processGO:003280010.1IL10, TNF
17positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, IL4, TNF
18negative regulation of cytokine secretion involved in immune responseGO:000274010.0IL10, TNF
19response to bacteriumGO:000961710.0IL6, NOS2
20negative regulation of interleukin-6 productionGO:00327159.9IL10, TNF
21innate immune response in mucosaGO:00022279.9IL4, NOS2
22cellular response to dexamethasone stimulusGO:00715499.8IL6, SERPINF1
23type 2 immune responseGO:00420929.8IL10, IL4
24negative regulation of gene expressionGO:00106299.7IFNG, SERPINF1, TNF
25negative regulation of growth of symbiont in hostGO:00441309.7IFNG, IL10, TNF
26negative regulation of endothelial cell apoptotic processGO:20003529.7IL10, IL4
27negative regulation of nitric oxide biosynthetic processGO:00450199.6IL10, IL4
28cellular response to hepatocyte growth factor stimulusGO:00357299.6IL10, IL6
29response to glucocorticoidGO:00513849.4IL10, IL6, TNF
30positive regulation of MHC class II biosynthetic processGO:00453489.3IFNG, IL10, IL4
31cellular response to lipopolysaccharideGO:00712229.1IFNG, IL6, NOS2, TNF
32defense response to protozoanGO:00428329.0IFNG, IL10, IL4, IL6
33positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL10, IL4, IL6, TNF
34inflammatory responseGO:00069548.8IL10, IL6, NOS2, TNF
35defense response to bacteriumGO:00427428.6IFNG, IL10, NOS2, TNF
36agingGO:00075688.6CP, IL10, IL6, SOD1
37positive regulation of transcription, DNA-templatedGO:00458938.5IFNG, IL10, IL4, IL6, TNF
38response to drugGO:00424938.3IFNG, IL10, IL4, IL6, SOD1
39immune responseGO:00069558.2IFNG, IL10, IL4, IL6, TNF
40positive regulation of transcription from RNA polymerase II promoterGO:00459448.1IFNG, IL10, IL4, IL6, TNF

Sources for Eales Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet