MCID: ELS001
MIFTS: 45

Eales Disease malady

Categories: Rare diseases, Eye diseases, Cardiovascular diseases

Aliases & Classifications for Eales Disease

About this section
Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Eales Disease:

Name: Eales Disease 45 47 51 65
Idiopathic Recurrent Vitreal Hemorrhage 45
Idiopathic Obliterative Vasculopathy 45
 
Idiopathic Retinal Perivasculitis 51
Idiopathic Retinal Vasculitis 51

Characteristics:

Orphanet epidemiological data:

51
eales disease:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Orphanet51 40923
ICD10 via Orphanet28 H35.0
MESH via Orphanet37 C538011
UMLS via Orphanet66 C0271073
UMLS65 C0271073

Summaries for Eales Disease

About this section
NIH Rare Diseases:45 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards based summary: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to bronchopulmonary dysplasia and rheumatoid arthritis. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1, Soluble), and among its related pathways are MSP-RON Signaling and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include retina, eye and breast, and related mouse phenotypes are tumorigenesis and muscle.

Wikipedia:68 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

About this section

Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1bronchopulmonary dysplasia29.7IFNG, IL10, IL6, TNF
2rheumatoid arthritis29.4IFNG, IL10, IL4, IL6, TNF
3irvan syndrome12.0
4autoimmune oophoritis10.5IFNG, TNF
5non-distal monosomy 10q10.5IFNG, TNF
6ethmoid sinus squamous cell carcinoma10.5IFNG, TNF
7parasitic ichthyosporea infectious disease10.4IFNG, TNF
8hair defect with photosensitivity and mental retardation10.4TF, TNF
9warty dyskeratoma10.4TF, TNF
10cerebral sarcoidosis10.4SERPINF1, TNF
11plantar nerve lesion10.4IL6, TNF
12intermediate dend syndrome10.4IL6, TNF
13crohn's disease10.4IL6, TNF
14malignant sertoli-leydig cell tumor of ovary10.4IL6, TNF
15atrichia with papular lesions10.4IFNG, TNF
16mammary paget's disease10.3IL6, TNF
17lujo hemorrhagic fever10.3IL6, TNF
18breast cancer10.3
19thyroiditis10.3
20posterior valve urethra10.3IL6, TNF
21cryptosporidiosis10.3IFNG, TF, TNF
22t cell immunodeficiency primary10.3IL6, TNF
23residual stage angle-closure glaucoma10.3IL6, TNF
24legionellosis10.3IFNG, NOS2, SOD1
25limbic encephalitis with ncmags antibodies10.3IFNG, IL4
26paranoid schizophrenia10.3IL6, TNF
27granulomas, congenital cerebral10.3CP, TNF
28progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome10.3CP, IFNG
29arthritis10.2
30hypophosphatemia10.2
31melanoma10.2
32ischemic optic neuropathy10.2IL6, TNF
33fatal infantile encephalocardiomyopathy10.2CP, SOD1
34parovarian cyst10.2IL6, TF, TNF
35pityriasis rosea10.2RBP3, SAG
36conventional malignant hemangiopericytoma10.2IFNG, IL6, TNF
37motion sickness10.2IFNG, IL6, TNF
38gonococcal bursitis10.2IFNG, IL4, TNF
39chronic lymphocytic leukemia10.2IL6, SOD1, TF
40epidermolysis bullosa dystrophica10.2IL6, TF, TNF
41soft palate cancer10.2IFNG, IL4, TNF
42hepatoid adenocarcinoma10.2IFNG, IL4, TNF
43spinal muscular atrophy10.2IL6, NOS2, TNF
44listeria meningitis10.2NOS2, SAG, SOD1
45reflex sympathetic dystrophy10.2IFNG, IL4, TNF
46punctate palmoplantar keratoderma type 210.2IL10, TNF
47leukoplakia of penis10.2IFNG, IL4, TNF
48cri-du-chat syndrome10.1RBP3, SAG, TNF
49congenital dyserythropoietic anemia10.1IFNG, IL6
50autosomal recessive type iv ehlers-danlos syndrome10.1IFNG, SERPINF1

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Symptoms for Eales Disease

About this section

Drugs & Therapeutics for Eales Disease

About this section

Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RanibizumabapprovedPhase 2, Phase 3460347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
2Immunologic FactorsPhase 2, Phase 318483
3Angiogenesis Modulating AgentsPhase 2, Phase 33611
4Angiogenesis InhibitorsPhase 2, Phase 33688

Interventional clinical trials:

idNameStatusNCT IDPhase
1Lucentis (Ranibizumab) for Eales' DiseaseCompletedNCT00384449Phase 2, Phase 3

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

About this section

Anatomical Context for Eales Disease

About this section

MalaCards organs/tissues related to Eales Disease:

33
Retina, Eye, Breast, Bone, T cells, Kidney, Placenta

Animal Models for Eales Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Eales Disease:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IFNG, IL10, IL6, NOS2, SOD1, TNF
2MP:00053698.1IFNG, IL10, IL6, NOS2, SOD1, TNF
3MP:00053888.1IFNG, IL10, IL4, IL6, NOS2, TNF
4MP:00107717.9IFNG, IL10, IL4, IL6, NOS2, SOD1
5MP:00053817.6IFNG, IL10, IL4, IL6, NOS2, SERPINF1
6MP:00053797.5IFNG, IL10, IL4, IL6, NOS2, SERPINF1
7MP:00053897.4IFNG, IL10, IL4, IL6, NOS2, SERPINF1
8MP:00053707.3CP, IFNG, IL10, IL4, IL6, NOS2
9MP:00053847.1CP, IFNG, IL10, IL4, IL6, NOS2
10MP:00053907.1IFNG, IL10, IL4, IL6, NOS2, SERPINF1
11MP:00053857.0CP, IFNG, IL10, IL6, NOS2, SERPINF1
12MP:00053876.8CP, IFNG, IL10, IL4, IL6, NOS2
13MP:00053976.2CP, IFNG, IL10, IL4, IL6, NOS2
14MP:00053766.2CP, IFNG, IL10, IL4, IL6, NOS2
15MP:00053915.9CP, IFNG, IL10, IL4, IL6, NOS2
16MP:00036315.8CP, IFNG, IL10, IL4, IL6, NOS2

Publications for Eales Disease

About this section

Articles related to Eales Disease:

(show all 50)
idTitleAuthorsYear
1
Adjunctive retigabine in refractory focal epilepsy: Postmarketing experience at four tertiary epilepsy care centers in Germany. (26828693)
2016
2
Emergence of community-acquired adenovirus type 55 as a cause of community-onset pneumonia. (24077315)
2014
3
Clinical Characteristics of Scleritis and Episcleritis: Results from the Pacific Ocular Inflammation Study. (24295070)
2013
4
Female with rash, acute kidney failure and rheumatoid arthritis. (23023360)
2012
5
The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells. (21372145)
2011
6
Upward squatting in individuals with and without patellofemoral pain syndrome: a biomechanical study. (21273914)
2011
7
Spasticity: revisiting the role and the individual value of several pharmacological treatments. (20871149)
2010
8
Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. (20637175)
2010
9
Oscillating migration and the epidemics of silicosis, tuberculosis, and HIV infection in South African gold miners. (19565628)
2010
10
Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice. (19900484)
2010
11
A closer look at age: deconstructing aggregate gonorrhea and chlamydia rates, California, 1998-2007. (20182408)
2010
12
Ovarian mucinous cystadenoma of borderline malignancy in a premenarchal girl. (19896401)
2010
13
The effect of Bcl-2, YAMA, and XIAP over-expression on apoptosis and adenovirus production in HEK293 cell line. (19623569)
2009
14
Effect of BMP-2 and BMP-7 homodimers and a mixture of BMP-2/BMP-7 homodimers on osteoblast adhesion and growth following culture on a collagen scaffold. (18458495)
2008
15
Long-term efficacy of a low-pressure adjustable gastric band in the treatment of morbid obesity. (18438114)
2008
16
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (18411503)
2008
17
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication. (17200910)
2007
18
Human recombinant erythropoietin does not promote cancer growth in presence of functional receptors expressed in cancer cells. (17938574)
2007
19
Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. (17143517)
2007
20
Laparoscopically guided uterine entry for fetoscopy in twin-to-twin transfusion syndrome with completely anterior placenta: a novel technique. (17652926)
2007
21
Genetic determinants of bone mass do not relate with breast cancer risk in US white and African-American women. (16791482)
2006
22
Selective recruitment of CXCR3+ and CCR5+ CCR4+ T cells into synovial tissue in patients with rheumatoid arthritis. (16838043)
2006
23
Structural and antitumor properties of the YSNSG cyclopeptide derived from tumstatin. (17185226)
2006
24
Multidisciplinary surgical approach to a surviving infant with sirenomelia. (16801393)
2006
25
Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? (15762869)
2005
26
Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. (15946692)
2005
27
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. (15164420)
2004
28
Dendritic cell infiltration and prognosis of early stage breast cancer. (15569976)
2004
29
Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. (11994416)
2002
30
Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors. (12483719)
2002
31
PTEN expression in tamoxifen-associated endometrial cancers. (12530022)
2002
32
MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome. (11331619)
2001
33
Cerebrospinal fluid from patients with neurodegenerative and neuroinflammatory diseases: no evidence for rat glial activation in vitro. (11704295)
2001
34
Identification of novel first exons in Ad4BP/SF-1 (NR5A1) gene and their tissue- and species-specific usage. (11071856)
2000
35
Genetic instability did not lead to p53 mutations in an extremely early-onset breast cancer in a cancer-prone family. (10470657)
1999
36
JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia. (9129147)
1997
37
Relapsing polychondritis: a syndrome rather than a distinct clinical entity? (9177934)
1997
38
Activated protein C and pulmonary embolism. (8667962)
1996
39
Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform underlies catalytic superactivity of human phosphoribosylpyrophosphate synthetase. (8702702)
1996
40
c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter. (7721862)
1995
41
Expression of intermediate filaments in normal and neoplastic exocrine pancreas. (7524653)
1994
42
Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis. (8515117)
1993
43
Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase). (1734857)
1992
44
Effect of tumor size on the enhancement by gamma interferon of the localization of radiolabeled F(ab')2 fragments of anti-intercellular adhesion molecule-1 monoclonal antibodies in human colon carcinoma cells grafted in nude mice. (1346588)
1992
45
Two cases of steroid sulfatase deficiency with complex phenotype due to contiguous gene deletions. (1951426)
1991
46
The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. (1742021)
1991
47
Dose-dependent pharmacokinetics of the aldose reductase inhibitor imirestat in man. (1901647)
1991
48
Glucose-induced insulin secretion in uremia: effects of aminophylline infusion and glucose loads. (1963648)
1990
49
Selectivity of protein kinase inhibitors in human intact platelets. (2252838)
1990
50
Letter: Propranolol for causalgia. (4406294)
1974

Variations for Eales Disease

About this section

Expression for genes affiliated with Eales Disease

About this section
Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

About this section

Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show all 46)
idSuper pathwaysScoreTop Affiliating Genes
19.5IFNG, NOS2, TNF
29.5IL4, IL6
39.4IFNG, IL6, TNF
49.4IFNG, IL6, TNF
59.4IFNG, IL6, NOS2
6
Show member pathways
9.4IFNG, IL6, NOS2
7
Show member pathways
9.4IFNG, IL4, TNF
8
Show member pathways
9.3IFNG, IL4, NOS2
9
Show member pathways
9.2CP, NOS2, SOD1
109.2IL4, IL6, TNF
119.2IFNG, IL4, IL6
12
Show member pathways
9.2IFNG, IL4, IL6
139.2CP, NOS2, TF
14
Show member pathways
9.2IFNG, IL6, SOD1, TNF
159.1IFNG, IL6, NOS2, TNF
169.1IFNG, IL6, NOS2, TNF
17
Show member pathways
9.1IFNG, IL6, NOS2, TNF
18
Show member pathways
9.1IFNG, IL10, TNF
199.1IFNG, IL6, NOS2, TF
208.9IL10, IL6, TNF
218.9IFNG, IL10, IL6
228.8IFNG, IL10, IL4
238.8IFNG, IL10, IL4
24
Show member pathways
8.6IFNG, IL10, IL6, TNF
258.6IFNG, IL10, IL6, TNF
268.6IFNG, IL10, IL6, TNF
278.6IFNG, IL10, IL6, TNF
288.6IL10, IL6, TF, TNF
298.6IL10, IL6, NOS2, TNF
30
Show member pathways
8.6IFNG, IL4, IL6, NOS2, TNF
318.6IFNG, IL4, IL6, NOS2, TNF
328.5IFNG, IL10, IL4, TNF
33
Show member pathways
8.4IFNG, IL10, IL4, IL6
348.3IFNG, IL10, IL6, NOS2, TNF
35
Show member pathways
8.3IFNG, IL10, IL6, NOS2, TNF
368.3IFNG, IL10, IL6, NOS2, TNF
37
Show member pathways
8.3IFNG, IL10, IL6, NOS2, TNF
38
Show member pathways
8.2IFNG, IL10, IL4, NOS2, TNF
398.1IFNG, IL10, IL4, IL6, TNF
40
Show member pathways
8.1IFNG, IL10, IL4, IL6, TNF
41
Show member pathways
8.1IFNG, IL10, IL4, IL6, TNF
428.1IFNG, IL10, IL4, IL6, TNF
43
Show member pathways
8.1IFNG, IL10, IL4, IL6, TNF
448.0IL10, IL4, IL6, NOS2, TNF
45
Show member pathways
7.7IFNG, IL10, IL6, NOS2, SOD1, TF
46
Show member pathways
7.3IFNG, IL10, IL4, IL6, NOS2, SERPINF1

GO Terms for genes affiliated with Eales Disease

About this section

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IFNG, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.6IFNG, TNF
3retina homeostasisGO:000189510.5SOD1, TF
4neutrophil apoptotic processGO:000178110.4IFNG, IL6
5epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
6positive regulation of cytokine productionGO:000181910.4SOD1, TNF
7protein import into nucleus, translocationGO:000006010.4IFNG, TNF
8response to antibioticGO:004667710.4IL6, SOD1
9myeloid cell homeostasisGO:000226210.4IL6, SOD1
10positive regulation of mononuclear cell migrationGO:007167710.4IL4, TNF
11negative regulation of lipid storageGO:001088810.3IL6, TNF
12positive regulation of osteoclast differentiationGO:004567210.3IFNG, TNF
13positive regulation of T cell proliferationGO:004210210.2IFNG, IL4
14positive regulation of isotype switching to IgG isotypesGO:004830410.2IFNG, IL4
15superoxide metabolic processGO:000680110.1NOS2, SOD1
16receptor biosynthetic processGO:003280010.1IL10, TNF
17positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, IL4, TNF
18negative regulation of cytokine secretion involved in immune responseGO:000274010.0IL10, TNF
19response to bacteriumGO:000961710.0IL6, NOS2
20negative regulation of interleukin-6 productionGO:00327159.9IL10, TNF
21innate immune response in mucosaGO:00022279.9IL4, NOS2
22cellular response to dexamethasone stimulusGO:00715499.8IL6, SERPINF1
23type 2 immune responseGO:00420929.8IL10, IL4
24negative regulation of gene expressionGO:00106299.7IFNG, SERPINF1, TNF
25negative regulation of growth of symbiont in hostGO:00441309.7IFNG, IL10, TNF
26negative regulation of endothelial cell apoptotic processGO:20003529.7IL10, IL4
27negative regulation of nitric oxide biosynthetic processGO:00450199.6IL10, IL4
28cellular response to hepatocyte growth factor stimulusGO:00357299.6IL10, IL6
29response to glucocorticoidGO:00513849.4IL10, IL6, TNF
30positive regulation of MHC class II biosynthetic processGO:00453489.3IFNG, IL10, IL4
31cellular response to lipopolysaccharideGO:00712229.1IFNG, IL6, NOS2, TNF
32defense response to protozoanGO:00428329.0IFNG, IL10, IL4, IL6
33positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL10, IL4, IL6, TNF
34inflammatory responseGO:00069548.8IL10, IL6, NOS2, TNF
35defense response to bacteriumGO:00427428.6IFNG, IL10, NOS2, TNF
36agingGO:00075688.6CP, IL10, IL6, SOD1
37positive regulation of transcription, DNA-templatedGO:00458938.5IFNG, IL10, IL4, IL6, TNF
38response to drugGO:00424938.3IFNG, IL10, IL4, IL6, SOD1
39immune responseGO:00069558.2IFNG, IL10, IL4, IL6, TNF
40positive regulation of transcription from RNA polymerase II promoterGO:00459448.1IFNG, IL10, IL4, IL6, TNF

Sources for Eales Disease

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet