MCID: ELS001
MIFTS: 48

Eales Disease malady

Rare diseases, Eye diseases, Cardiovascular diseases categories
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Summaries for Eales Disease

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. this condition is most common among young males and normally affects both eyes. in most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. visual prognosis is good if treatment begins early in the course of the disease.  last updated: 6/13/2011

MalaCards: Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinal vasculitis and proliferative diabetic retinopathy. An important gene associated with Eales Disease is SAG (S-antigen; retina and pineal gland (arrestin)), and among its related pathways are Mechanisms of CFTR activation by S nitrosoglutathione normal and CF and Selected targets of ESR1. The compounds randox and dmpo-oh have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and thyroid, and related mouse phenotypes are vision/eye and liver/biliary system.

Wikipedia:65 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Aliases & Classifications for Eales Disease

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Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Cardiovascular diseases
Orphanet: 49 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

49
eales disease:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

eales disease 43 45 49 62
idiopathic recurrent vitreal hemorrhage 43
idiopathic obliterative vasculopathy 43


External Ids:

MESH via Orphanet36 C538011
ICD10 via Orphanet26 H35.0
SNOMED-CT via Orphanet59 54122009
UMLS via Orphanet63 C0271073

Related Diseases for Eales Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Eales Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis30.8SAG
2proliferative diabetic retinopathy30.3VEGFA, SERPINF1
3diabetic retinopathy30.2VEGFA, SERPINF1, SOD1, SAG
4retinal detachment30.1VEGFA, SERPINF1
5melanoma30.0VEGFA, SERPINF1, CP, SAG
6retinitis10.6
7vasculitis10.4
8choroiditis10.2
9tuberculosis10.2
10aceruloplasminemia10.1CP
11retinopathy of prematurity10.1VEGFA
12retinal vascular occlusion10.1F5
13endophthalmitis10.1VEGFA, SAG
14senile cataract10.1SOD1, SERPINF1
15eye disease10.1SERPINF1, SAG
16pneumoconiosis10.1SOD1, CP
17blindness10.1SERPINF1, VEGFA
18macular retinal edema10.1VEGFA, SERPINF1
19menkes disease10.1SOD1, CP
20retinal vascular disease10.0VEGFA, SERPINF1
21corneal neovascularization10.0VEGFA, SERPINF1
22diabetic macular edema10.0VEGFA, SERPINF1
23uveitis10.0SERPINF1, SAG
24retinal vein occlusion10.0F5, VEGFA
25central retinal vein occlusion10.0F5, VEGFA
26ovarian hyperstimulation syndrome10.0F5, VEGFA
27hyperhomocysteinemia10.0F5, SOD1
28internuclear ophthalmoplegia10.0
29retinal ischemia10.0
30chorioretinitis10.0
31encephalitis10.0
32hypothyroidism10.0
33ischemia10.0
34malignant choroid melanoma10.0
35neuropathy10.0
36ophthalmoplegia10.0
37peripheral neuropathy10.0
38thyroiditis10.0
39serpiginous choroiditis10.0
40spastic paraparesis10.0
41spasticity10.0
42endotheliitis10.0
43alcoholic liver cirrhosis10.0TF, SOD1
44hypochromic microcytic anemia10.0TF, CP
45huntington's disease10.0SOD1, CP
46retinal degeneration10.0SERPINF1, CP, SAG
47hemosiderosis10.0CP, TF
48cataract10.0SERPINF1, SOD1
49siderosis10.0CP, TF
50uremia10.0SOD1, TF

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to eales disease

Symptoms for Eales Disease

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Drugs & Therapeutics for Eales Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Eales Disease

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

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Anatomical Context for Eales Disease

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Sources:
33MalaCards
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MalaCards organs/tissues related to Eales Disease:

33
Retina, Eye, Thyroid, Monocytes, Endothelial

Animal Models for Eales Disease or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Eales Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3SAG, SOD1, CP, SERPINF1, VEGFA
2MP:00053708.1VEGFA, CP, SOD1, F5
3MP:00053857.8VEGFA, SERPINF1, CP, SOD1, F5
4MP:00053767.6F5, SOD1, CP, VEGFA, TF
5MP:00036317.6VEGFA, SERPINF1, CP, SOD1, SAG, F5

Publications for Eales Disease

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Sources:
52PubMed
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Articles related to Eales Disease:

(show all 44)
idTitleAuthorsYear
1
Profiling of human leukocyte antigens in Eales disease and tuberculosis. (23386050)
2013
2
Eales disease associated with serpiginous choroiditis. (23143459)
2012
3
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. (22169980)
2012
4
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. (23198627)
2012
5
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. (21849807)
2011
6
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. (20720222)
2011
7
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. (22025890)
2011
8
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. (21394064)
2011
9
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. (21301382)
2011
10
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. (20533927)
2010
11
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. (20072643)
2009
12
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. (19585364)
2009
13
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). (18936719)
2009
14
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. (18536597)
2008
15
Intravitreal injection of bevacizumab in Eales disease. (18379947)
2008
16
Eales' disease: oxidant stress and weak antioxidant defence. (17322597)
2007
17
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (17536031)
2007
18
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. (17392871)
2007
19
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. (17852192)
2007
20
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. (16980931)
2007
21
Intravitreal triamcinolone acetonide in Eales disease. (16467685)
2006
22
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. (16133465)
2006
23
HLA typing in patients of Eales disease. (15907240)
2005
24
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. (15283219)
2004
25
Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy. (15512947)
2004
26
Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy. (14632162)
2003
27
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. (12849870)
2003
28
Usefulness of laser photocoagulation in managing asymptomatic eyes of Eales disease. (12688097)
2002
29
Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). (12386081)
2002
30
Osseous metaplasia in an epiretinal membrane in eales disease. (12441733)
2002
31
Eales disease--an update. (12052408)
2002
32
Mycobacterium tuberculosis infection complicated by Eales disease with peripheral neuropathy. (12355398)
2002
33
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. (9873227)
1999
34
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. (10487964)
1999
35
Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation. (9683168)
1998
36
Long term visual results of vitrectomy for Eales disease complications. (10090452)
1998
37
Vitrectomy for complicated Eales disease. (11189322)
1997
38
Chronic encephalitis and Eales disease. (8326335)
1993
39
Visualization of retinal vasculitis in Eales' disease. (22827191)
1993
40
Eales' disease with progressive spastic paraparesis. (8226608)
1993
41
Eales disease with internuclear ophthalmoplegia. (1514745)
1992
42
Serum alpha-1 acid glycoprotein levels in patients with idiopathic peripheral retinal vasculitis (Eales' disease). (1414297)
1992
43
Unusual association of Eales disease with multifocal neurological deficit. (6530368)
1984
44
Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy, and malignant choroidal melanoma. (700971)
1978

Variations for Eales Disease

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Expression for genes affiliated with Eales Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for genes affiliated with Eales Disease

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Sources:
50PathCards, 60Thomson Reuters, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 55Reactome
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Compounds for genes affiliated with Eales Disease

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR
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Compounds related to Eales Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1randox459.9SOD1, CP
2dmpo-oh459.9SOD1, CP
3verteporfin459.9SERPINF1, VEGFA
4dmpo459.8SOD1, CP
5thiobarbituric acid459.7SOD1, CP
6carnosine45 2410.7SOD1, CP
7gliclazide45 51 1111.5SOD1, VEGFA
8ferrozine459.5TF, CP
9ferrous ammonium sulfate459.5TF, CP
10diphenyleneiodonium459.5SOD1, SERPINF1, VEGFA
11sodium azide459.4CP, SOD1
12desogestrel45 1110.4F5, CP
13apotransferrin459.4CP, TF
14ferric ammonium citrate459.4CP, TF
15gestodene45 1110.3CP, F5
16malondialdehyde459.3CP, SOD1, F5
17uric acid45 2410.3F5, SOD1, CP
18vitamin-e459.3CP, SOD1, F5
19azide459.2SOD1, CP
20suprofen45 1110.2TF, CP, SOD1
21fenton459.2SOD1, CP, TF
22dehydroascorbic acid45 1110.2TF, CP, SOD1
23dtpa459.2SOD1, CP, TF
24tocopherol459.1SOD1, CP, TF
25deferoxamine45 1110.1SOD1, CP, TF
26selenium45 2410.1TF, CP, SOD1
27triamcinolone acetonide45 2910.1SERPINF1, VEGFA, TF
28betacarotene459.1SOD1, CP, TF
29alpha tocopherol459.0TF, CP, SOD1
30sodium nitroprusside459.0SOD1, CP, TF
31vitamin b12458.9F5, CP, TF
32levodopa45 119.8SAG, SOD1, CP, TF
33vitamin a45 24 1110.8TF, CP, SOD1, SAG
34citrate458.8TF, CP, F5
35adenine45 24 1110.8F5, CP, TF
36cyclophosphamide45 51 1110.7TF, VEGFA, F5
37n acetylcysteine458.7TF, VEGFA, SERPINF1, SOD1
38folate458.6TF, CP, F5
39copper45 249.5TF, CP, SOD1, F5
40prostacyclin458.5TF, VEGFA, SOD1, F5
41ascorbic acid45 249.5F5, SOD1, CP, TF
42fluorescein45 119.5F5, SERPINF1, VEGFA, TF
43glutamine458.5TF, CP, SAG, F5
44aspartate458.4TF, CP, SAG, F5
45lactate458.4TF, CP, SOD1, F5
46creatinine458.4F5, SOD1, CP, TF
47heparin45 29 24 1111.4VEGFA, SERPINF1, CP, SAG, F5
48alanine458.1TF, CP, SOD1, SAG, F5
49vegf457.9TF, VEGFA, SERPINF1, CP, F5
50glutamate457.7TF, SERPINF1, CP, SOD1, SAG, F5

GO Terms for genes affiliated with Eales Disease

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16Gene Ontology
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Cellular components related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0F5, VEGFA
2extracellular vesicular exosomeGO:0700628.3SOD1, CP, SERPINF1, TF
3extracellular spaceGO:0056157.1F5, SOD1, CP, SERPINF1, VEGFA, TF
4extracellular regionGO:0055767.0TF, VEGFA, SERPINF1, CP, SOD1, F5

Biological processes related to Eales Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.5SERPINF1, VEGFA
2ovarian follicle developmentGO:0015419.2SOD1, VEGFA
3retina homeostasisGO:0018959.1TF, SOD1
4cellular iron ion homeostasisGO:0068798.8TF, CP, SOD1
5platelet degranulationGO:0025768.2F5, SOD1, VEGFA, TF
6platelet activationGO:0301688.2F5, SOD1, VEGFA, TF
7blood coagulationGO:0075968.1F5, SOD1, VEGFA, TF

Molecular functions related to Eales Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone bindingGO:0510879.5SOD1, CP
2copper ion bindingGO:0055078.6F5, SOD1, CP

Products for genes affiliated with Eales Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eales Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet