MCID: ERL012
MIFTS: 23

Early-Onset Glaucoma malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Early-Onset Glaucoma

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Aliases & Descriptions for Early-Onset Glaucoma:

Name: Early-Onset Glaucoma 23 65
 
Hereditary Glaucoma 23

Classifications:



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UMLS65 C3711383

Summaries for Early-Onset Glaucoma

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Genetics Home Reference:23 Glaucoma is a group of eye disorders in which the optic nerves connecting the eyes and the brain are progressively damaged. This damage can lead to reduction in side (peripheral) vision and eventual blindness. Other signs and symptoms may include bulging eyes, excessive tearing, and abnormal sensitivity to light (photophobia). The term "early-onset glaucoma" may be used when the disorder appears before the age of 40.

MalaCards based summary: Early-Onset Glaucoma, also known as hereditary glaucoma, is related to singleton-merten syndrome 1 and iridogoniodysgenesis, type 2. An important gene associated with Early-Onset Glaucoma is MYOC (Myocilin). Affiliated tissues include eye, brain and breast, and related mouse phenotype reproductive system.

Related Diseases for Early-Onset Glaucoma

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Diseases in the Juvenile Glaucoma family:

Glaucoma 3, Primary Infantile, B Glaucoma 3, Primary Congenital, D
Glaucoma 3, Primary Congenital, C Primary Congenital Glaucoma
Glaucoma Type 1c Glaucoma, Hereditary
Glaucoma, Hereditary Adult Type 1a Glaucoma, Hereditary Juvenile Type 1b
Glaucoma, Primary Infantile Type 3a Cyp1b1-Related Primary Congenital Glaucoma
Ltbp2-Related Primary Congenital Glaucoma early-onset glaucoma

Diseases related to Early-Onset Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
idRelated DiseaseScoreTop Affiliating Genes
1singleton-merten syndrome 110.4
2iridogoniodysgenesis, type 210.4
3glaucoma 1a, primary open angle10.2CYP1B1, MYOC
4hydrophthalmos10.2CYP1B1, MYOC
5primary familial brain calcification10.2CYP1B1, MYOC
6glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.2CYP1B1, MYOC
7bullous keratopathy10.2CYP1B1, MYOC
8paraurethral gland cancer10.2CYP1B1, MYOC
9larsen-like syndrome10.1CYP1B1, PITX2
10ring dermoid of cornea10.1MYOC, PITX2
11lung cancer10.1
12good syndrome10.1
13filariasis10.1
14trigeminal neuralgia10.1
15glossopharyngeal neuralgia10.1
16prostatitis10.1
17coccidiosis10.1
18splenic abscess10.1
19polymyositis10.1
20amyotrophic lateral sclerosis 1210.1CYP1B1, MYOC
21juvenile glaucoma10.1CYP1B1, MYOC
22dejerine-sottas disease10.0MTMR2, SBF2
23peters anomaly10.0CYP1B1, PITX2
24separation anxiety disorder9.9CYP1B1, MYOC, PITX2
25hypogonadotropic hypogonadism 24 without anosmia9.9CYP1B1, PITX2
26progesterone resistance9.7MTM1, MTMR2, SBF2
27charcot-marie-tooth neuropathy type 4j9.6MTMR2, SBF1, SBF2
28benign essential hypertension9.6MTMR2, SBF1, SBF2
29charcot-marie-tooth neuropathy dominant intermediate e9.6SBF1, SBF2
30lethal congenital contracture syndrome 59.2MTM1, MTMR2, SBF1, SBF2
31childhood type dermatomyositis9.2MTM1, MTMR2, SBF1, SBF2
32essential pentosuria8.4CYP1B1, MTM1, MTMR2, MYOC, PITX2, SBF1

Graphical network of the top 20 diseases related to Early-Onset Glaucoma:



Diseases related to early-onset glaucoma

Symptoms for Early-Onset Glaucoma

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Drugs & Therapeutics for Early-Onset Glaucoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Early-Onset Glaucoma

Genetic Tests for Early-Onset Glaucoma

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Anatomical Context for Early-Onset Glaucoma

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MalaCards organs/tissues related to Early-Onset Glaucoma:

33
Eye, Brain, Breast

Animal Models for Early-Onset Glaucoma or affiliated genes

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MGI Mouse Phenotypes related to Early-Onset Glaucoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.5MTM1, MTMR2, PITX2, SBF1, SBF2

Publications for Early-Onset Glaucoma

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Articles related to Early-Onset Glaucoma:

idTitleAuthorsYear
1
Prediction of poor prognosis in breast cancer patients based on microRNA-21 expression: a meta-analysis. (25706383)
2015
2
The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. (24196834)
2014
3
Cancer therapy-induced autonomic dysfunction in early breast cancer: Implications for aerobic exercise training. (24365613)
2014
4
Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. (23232072)
2012
5
Analysis of EMG signals of patients with essential tremor focusing on the change of tremor frequency. (23366370)
2012
6
Quantitative analysis of heparanase gene expression in normal cervical, cervical intraepithelial neoplastic, and cervical carcinoma tissues. (19955948)
2009
7
Prenatal and postnatal management of hyperprostaglandin E syndrome after genetic diagnosis from amniocytes. (10049979)
1999
8
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)
1999
9
Proinsulin, proinsulin intermediate and insulin in cystic fibrosis. (8348704)
1993
10
Atrophic gastritis after Billroth I gastrectomy. (446425)
1979

Variations for Early-Onset Glaucoma

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Expression for genes affiliated with Early-Onset Glaucoma

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Search GEO for disease gene expression data for Early-Onset Glaucoma.

Pathways for genes affiliated with Early-Onset Glaucoma

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GO Terms for genes affiliated with Early-Onset Glaucoma

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Biological processes related to Early-Onset Glaucoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol biosynthetic processGO:00066619.6MTM1, MTMR2
2phospholipid metabolic processGO:00066449.5MTM1, MTMR2
3protein dephosphorylationGO:00064709.3MTM1, MTMR2
4peptidyl-tyrosine dephosphorylationGO:00353359.0MTM1, MTMR2

Sources for Early-Onset Glaucoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet