MCID: ERL012
MIFTS: 26

Early-Onset Glaucoma malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Early-Onset Glaucoma

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Aliases & Descriptions for Early-Onset Glaucoma:

Name: Early-Onset Glaucoma 23 65
 
Hereditary Glaucoma 23

Classifications:



External Ids:

UMLS65 C3711383

Summaries for Early-Onset Glaucoma

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Genetics Home Reference:23 Glaucoma is a group of eye disorders in which the optic nerves connecting the eyes and the brain are progressively damaged. This damage can lead to reduction in side (peripheral) vision and eventual blindness. Other signs and symptoms may include bulging eyes, excessive tearing, and abnormal sensitivity to light (photophobia). The term "early-onset glaucoma" may be used when the disorder appears before the age of 40.

MalaCards based summary: Early-Onset Glaucoma, also known as hereditary glaucoma, is related to glaucoma 1a, primary open angle and hydrophthalmos. An important gene associated with Early-Onset Glaucoma is MYOC (Myocilin). Affiliated tissues include eye, brain and breast, and related mouse phenotype reproductive system.

Related Diseases for Early-Onset Glaucoma

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Diseases in the Juvenile Glaucoma family:

Glaucoma 3, Primary Infantile, B Glaucoma 3, Primary Congenital, D
Glaucoma 3, Primary Congenital, C Primary Congenital Glaucoma
Glaucoma Type 1c Glaucoma, Hereditary
Glaucoma, Hereditary Adult Type 1a Glaucoma, Hereditary Juvenile Type 1b
Glaucoma, Primary Infantile Type 3a Cyp1b1-Related Primary Congenital Glaucoma
Ltbp2-Related Primary Congenital Glaucoma early-onset glaucoma

Diseases related to Early-Onset Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma 1a, primary open angle10.4CYP1B1, MYOC
2hydrophthalmos10.3CYP1B1, MYOC
3primary familial brain calcification10.3CYP1B1, MYOC
4glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.3CYP1B1, MYOC
5bullous keratopathy10.3CYP1B1, MYOC
6paraurethral gland cancer10.2CYP1B1, MYOC
7larsen-like syndrome10.1CYP1B1, PITX2
8ring dermoid of cornea10.1MYOC, PITX2
9amyotrophic lateral sclerosis 1210.1CYP1B1, MYOC
10juvenile glaucoma10.1CYP1B1, MYOC
11singleton-merten syndrome 110.0
12iridogoniodysgenesis, type 210.0
13dejerine-sottas disease10.0MTMR2, SBF2
14peters anomaly10.0CYP1B1, PITX2
15cataract10.0
16weber syndrome10.0
17separation anxiety disorder9.9CYP1B1, MYOC, PITX2
18hypogonadotropic hypogonadism 24 without anosmia9.8CYP1B1, PITX2
19charcot-marie-tooth disease9.8
20tooth disease9.8
21progesterone resistance9.6MTM1, MTMR2, SBF2
22charcot-marie-tooth neuropathy type 4j9.4MTMR2, SBF1, SBF2
23benign essential hypertension9.4MTMR2, SBF1, SBF2
24charcot-marie-tooth neuropathy dominant intermediate e9.3SBF1, SBF2
25lethal congenital contracture syndrome 58.8MTM1, MTMR2, SBF1, SBF2
26childhood type dermatomyositis8.8MTM1, MTMR2, SBF1, SBF2
27essential pentosuria7.6CYP1B1, MTM1, MTMR2, MYOC, PITX2, SBF1

Graphical network of the top 20 diseases related to Early-Onset Glaucoma:



Diseases related to early-onset glaucoma

Symptoms for Early-Onset Glaucoma

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Drugs & Therapeutics for Early-Onset Glaucoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Early-Onset Glaucoma

Genetic Tests for Early-Onset Glaucoma

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Anatomical Context for Early-Onset Glaucoma

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MalaCards organs/tissues related to Early-Onset Glaucoma:

33
Eye, Brain, Breast, Lung, Prostate

Animal Models for Early-Onset Glaucoma or affiliated genes

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MGI Mouse Phenotypes related to Early-Onset Glaucoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.5MTM1, MTMR2, PITX2, SBF1, SBF2

Publications for Early-Onset Glaucoma

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Articles related to Early-Onset Glaucoma:

(show all 11)
idTitleAuthorsYear
1
Early-onset glaucoma in Axenfeld-Rieger anomaly: long-term surgical results and visual outcome. (27055677)
2016
2
Thin central corneal thickness and early-onset glaucoma in lacrimo-auriculo-dento-digital syndrome. (24921174)
2014
3
Determinants of severity at presentation among young patients with early onset glaucoma. (24212304)
2013
4
Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of Sh3pxd2b. (21282566)
2011
5
Incidence of early-onset glaucoma after infant cataract extraction with and without intraocular lens implantation. (19429583)
2009
6
Comparison of delayed-onset glaucoma and early-onset glaucoma after infantile cataract surgery. (16768189)
2006
7
Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma. (12687498)
2003
8
Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene. (11774072)
2002
9
Trabeculotomy-trabeculectomy for early-onset glaucoma. (10768320)
2000
10
Primary combined trabeculotomy-trabeculectomy for early-onset glaucoma in Sturge-Weber syndrome. (10442913)
1999
11
The efficacy of goniotomy/trabeculotomy in early-onset glaucoma associated with the Sturge-Weber syndrome. (10532726)
1998

Variations for Early-Onset Glaucoma

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Expression for genes affiliated with Early-Onset Glaucoma

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Search GEO for disease gene expression data for Early-Onset Glaucoma.

Pathways for genes affiliated with Early-Onset Glaucoma

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GO Terms for genes affiliated with Early-Onset Glaucoma

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Biological processes related to Early-Onset Glaucoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol biosynthetic processGO:00066619.6MTM1, MTMR2
2phospholipid metabolic processGO:00066449.5MTM1, MTMR2
3protein dephosphorylationGO:00064709.3MTM1, MTMR2
4peptidyl-tyrosine dephosphorylationGO:00353359.0MTM1, MTMR2

Sources for Early-Onset Glaucoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet