MCID: ERL020
MIFTS: 51

Early-Onset Schizophrenia malady

Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases categories
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Summaries for Early-Onset Schizophrenia

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33MalaCards
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MalaCards: Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and bipolar disorder. An important gene associated with Early-Onset Schizophrenia is DRD1 (dopamine receptor D1), and among its related pathways are dopamine degradation and Dopamine metabolism. The compounds eticlopride and (+)-butaclamol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are no phenotypic analysis and adipose tissue.

Aliases & Classifications for Early-Onset Schizophrenia

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49Orphanet, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases


Aliases & Descriptions:

early-onset schizophrenia 49
early onset schizophrenia 62


Related Diseases for Early-Onset Schizophrenia

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17GeneCards, 18GeneDecks
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Diseases in the Schizophrenia family:

Schizophrenia 4 Schizophrenia 12
Schizophrenia 17 Schizophrenia 14
Schizophrenia 16 Schizophrenia 13
Schizophrenia 10 Schizophrenia 15
early-onset schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9DRD3, COMT, HTR2A
2bipolar disorder30.7BDNF, SLC6A4
3mental retardation30.3DNMT3B, COMT, MAOA, DRD2, BDNF
4neuroleptic malignant syndrome30.3DRD2
5schizoaffective disorder30.0SLC6A4, BDNF, DRD2, HTR2A, COMT, DRD4
6obsessive-compulsive disorder29.9HTR2A, COMT, MAOA, DRD4, DRD3, DRD2
7attention deficit hyperactivity disorder29.9SLC6A4, BDNF, DBH, HTR2A, COMT, MAOA
8psychotic disorder29.8DRD3, DRD2, DRD1, BDNF, SLC6A4, DRD4
9alzheimer's disease29.7INS, DBH, HTR2A, COMT, MAOA, DRD4
10blindness10.4
11neuronitis10.4
12cerebritis10.4
13autism spectrum disorder10.3
14childhood-onset schizophrenia10.3
15oppositional defiant disorder10.1DRD4
16parametritis10.1
17periventricular leukomalacia10.1
18leukomalacia10.1
19striatonigral degeneration10.1DRD2
20melancholia10.1MAOA
21endogenous depression10.1MAOA
22paranoid schizophrenia10.1COMT
23obsessive-compulsive personality disorder10.1SLC6A4
24delusional disorder10.1DRD2, DRD4
25alcoholic psychosis10.1SLC6A4
26riley-day syndrome10.1DBH, BDNF
27opiate dependence10.1DRD3, DRD2
28heroin dependence10.1DRD2, DRD4
29anorexia nervosa10.1HTR2A, BDNF
30serotonin syndrome10.1MAOA, HTR2A
31pure autonomic failure10.1DBH, MAOA
32dysthymic disorder10.1HTR2A, MAOA
33peripheral vascular disease10.1INS
34gilles de la tourette syndrome10.1DRD2, DRD4
35familial mediterranean fever10.1TNF, DBH
36aids dementia complex10.1BDNF, TNF
37hyperprolactinemia10.1DBH, DRD4, DRD2
38memory impairment10.0HTR2A, DRD1, BDNF
39movement disease10.0DRD2, DRD3
40huntington's disease10.0DRD2, DRD1, BDNF
41portal hypertension10.0HTR2A, MAOA
42multiple system atrophy10.0DRD2, DBH
43pathological gambling10.0DRD4, DRD3, DRD2, DRD1
44borderline personality disorder10.0MAOA, SLC6A4
45drug addiction10.0DRD3, DRD2, DRD1, BDNF
46chronic fatigue syndrome10.0MAOA, SLC6A4
47carcinoid syndrome10.0DBH, HTR2A, MAOA
48nicotine dependence10.0SLC6A4, DRD2, DRD4
49cocaine abuse10.0SLC6A4, DRD2, DBH
50autistic disorder10.0SLC6A4, BDNF, DRD4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to early-onset schizophrenia

Symptoms for Early-Onset Schizophrenia

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Drugs & Therapeutics for Early-Onset Schizophrenia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Early-Onset Schizophrenia

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

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Anatomical Context for Early-Onset Schizophrenia

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33MalaCards
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MalaCards organs/tissues related to Early-Onset Schizophrenia:

33
Brain, Testes, Cortex, Temporal lobe, Cingulate cortex

Animal Models for Early-Onset Schizophrenia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

37 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1BDNF, DRD2, DNMT3B, TNF, INS
2MP:00053758.1INS, TNF, DBH, DRD3, DRD2, DRD1
3MP:00053917.8INS, TNF, DBH, DNMT3B, DRD4, DRD1
4MP:00053817.7INS, TNF, HTR2A, DRD3, DRD2, DRD1
5MP:00053907.7INS, TNF, DBH, HTR2A, DNMT3B, DRD2
6MP:00053697.6INS, TNF, HTR2A, DRD2, DRD1, SLC6A4
7MP:00053797.5INS, TNF, DBH, HTR2A, DRD2, SLC6A4
8MP:00107717.5INS, TNF, DBH, DRD2, DRD1, BDNF
9MP:00053897.4INS, TNF, DNMT3B, COMT, DRD2, BDNF
10MP:00053787.0INS, TNF, DBH, DNMT3B, DRD3, DRD2
11MP:00107686.9INS, TNF, DBH, DNMT3B, DRD3, DRD2
12MP:00053856.5INS, TNF, DBH, DNMT3B, COMT, MAOA
13MP:00053766.1COMT, DBH, TNF, INS, MAOA, DRD4
14MP:00036315.9COMT, DNMT3B, DBH, TNF, INS, MAOA
15MP:00053865.8SLC6A4, INS, TNF, DBH, HTR2A, COMT

Publications for Early-Onset Schizophrenia

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52PubMed
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Articles related to Early-Onset Schizophrenia:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
2
Aberrant default mode functional connectivity in early onset schizophrenia. (23923052)
2013
3
Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings. (24012081)
2013
4
Changes in the diagnosed incidence of early onset schizophrenia over four decades. (22906158)
2013
5
Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia. (22354179)
2012
6
Visual backward-masking performance in a longitudinal study of early onset schizophrenia. (22673182)
2012
7
Treatment of early onset schizophrenia: recent trends, challenges and future considerations. (22485097)
2012
8
Effect of SOX10 gene polymorphism on early onset schizophrenia in Chinese Han population. (22640896)
2012
9
A meta-analysis of neuropsychological functioning in patients with early onset schizophrenia and pediatric bipolar disorder. (21391023)
2011
10
Neuronal basis of haedonic appraisal in early onset schizophrenia: FMRI investigation. (24059618)
2011
11
Brain functional connectivity of functional magnetic resonance imaging of patients with early-onset schizophrenia. (20130360)
2010
12
Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia. (19894076)
2010
13
Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study. (20494268)
2010
14
Molecular-genetic study of early-onset schizophrenia]. (20436453)
2010
15
Deficient maturation of aspects of attention and executive functions in early onset schizophrenia. (20680364)
2010
16
Antipsychotic treatment of first-episode or early-onset schizophrenia. (19635232)
2009
17
The use of aripiprazole in early onset schizophrenia: safety and efficacy. (20527278)
2009
18
Aripiprazole as an adjunct to clozapine therapy in adolescents with early-onset schizophrenia: a retrospective chart review. (19585394)
2009
19
Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study. (18759640)
2008
20
A diffusion tensor imaging study of white matter in early-onset schizophrenia. (17662964)
2008
21
Metabolic side effects of risperidone in children and adolescents with early-onset schizophrenia. (19287568)
2008
22
Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. (18794207)
2008
23
Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders. (18533765)
2008
24
The Maudsley early onset schizophrenia study: cognitive function over a 4-year follow-up period. (18024468)
2008
25
The Maudsley early onset schizophrenia study. Predictors of psychosocial outcome at 4-year follow-up. (17896122)
2007
26
Pathophysiology of early onset schizophrenia. (17671865)
2007
27
Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. (16920078)
2007
28
Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test. (16309895)
2006
29
Lateralized deficit of response inhibition in early-onset schizophrenia. (16336744)
2006
30
Antipsychotics in early onset Schizophrenia: Systematic review and meta-analysis. (16470340)
2006
31
White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. (16113622)
2005
32
Early-onset schizophrenia: a 15-year follow-up. (16220219)
2005
33
Normal cerebral volume asymmetries in early onset schizophrenia. (14732594)
2004
34
Attenuation of perceptual asymmetries in patients with early-onset schizophrenia: evidence in favour of reduced hemispheric differentiation in schizophrenia? (15382732)
2004
35
The Maudsley early onset schizophrenia study: cognitive function in adolescents with recent onset schizophrenia. (12729865)
2003
36
Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry. (11793166)
2002
37
Associations between premorbid intellectual performance, early-life exposures and early-onset schizophrenia. Cohort study. (12356656)
2002
38
Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. (11481166)
2001
39
Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. (11378311)
2001
40
Structural magnetic imaging of the hippocampus in early onset schizophrenia. (11343679)
2001
41
Cognitive functions and psychopathological symptoms in early-onset schizophrenia. (10795851)
2000
42
Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images. (10964865)
2000
43
Blood biogenic amines during clozapine treatment of early-onset schizophrenia. (9503259)
1997
44
Is a child's risk of early onset schizophrenia increased in the highest social class? (9075303)
1997
45
A preliminary study on early onset schizophrenia and bipolar disorder: large polyglutamine expansions are not involved. (9335205)
1997
46
Predicting outcome in child and adolescent (early onset) schizophrenia and bipolar disorder. (1537767)
1992
47
Expressed emotion and early onset schizophrenia: a one year follow-up. (1946856)
1991
48
A chart review study of late-onset and early-onset schizophrenia. (2574011)
1989
49
Developmental arrest of cerebral asymmetries in early onset schizophrenia. (2608767)
1989
50
Reduced activity of angiotensin-converting enzyme in basal ganglia in early onset schizophrenia. (6247736)
1980

Variations for Early-Onset Schizophrenia

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Expression for genes affiliated with Early-Onset Schizophrenia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for genes affiliated with Early-Onset Schizophrenia

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 51PharmGKB, 60Thomson Reuters
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Pathways related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MAOA, COMT
29.6MAOA, COMT
3
Show member pathways
9.6MAOA, COMT
49.6DRD4, DRD2, DRD1
59.6HTR2A, DRD4, DRD3
6
Show member pathways
9.5DRD1, DRD2, HTR2A
7
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
9.3DRD4, DRD3, DRD2, DRD1
89.3DRD4, DRD3, DRD2, DRD1
99.3INS, YWHAH
10
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.3MAOA, COMT, DBH
11
Show member pathways
catecholamine biosynthesis38
9.3MAOA, COMT, DBH
129.3DBH, COMT, MAOA
139.2SLC6A4, MAOA, HTR2A
14
Show member pathways
9.2MAOA, DRD2, DRD1, BDNF
159.1TNF, YWHAH
16
Show member pathways
9.0HTR2A, DRD4, DRD3, DRD2, DRD1
17
Show member pathways
9.0HTR2A, DRD4, DRD3, DRD2, DRD1
18
Show member pathways
Serotonin Transporter Activity38
8.4SLC6A4, MAOA, DBH, TNF
19
Show member pathways
8.3INS, HTR2A, DRD4, DRD3, DRD2, DRD1
20
Show member pathways
8.2BDNF, TNF, YWHAH, INS
21
Show member pathways
8.1INS, TNF, DRD2, DRD1, BDNF
22
Show member pathways
7.9INS, YWHAH, DRD4, DRD3, DRD2, DRD1
23
Show member pathways
7.7INS, TNF, MAOA, DRD2, DRD1, BDNF
24
Show member pathways
7.6SLC6A4, HTR2A, COMT, MAOA, DRD4, DRD3
257.5YWHAH, TNF, HTR2A, MAOA, BDNF, SLC6A4

Compounds for genes affiliated with Early-Onset Schizophrenia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 217)
idCompoundScoreTop Affiliating Genes
1eticlopride45 2910.6DRD1, DRD4, DRD3, DRD2
2(+)-butaclamol45 2910.4HTR2A, DRD4, DRD3, DRD1, DRD2
3raclopride45 2910.3DRD4, HTR2A, DRD1, DRD2, DRD3
4spiperone45 2910.3DRD4, DRD3, DRD2, DRD1, HTR2A
5lisuride45 29 1111.3DRD1, DRD2, DRD3, DRD4, HTR2A
6paliperidone45 1110.2DRD1, HTR2A, DRD4, DRD2, DRD3
7sch 23390459.2DRD2, DRD1, DRD4, DRD3
8iloperidone51 45 29 1112.2HTR2A, DRD3, DRD2, DRD1, DRD4
9remoxipride45 1110.2DRD2, DRD3, DRD4, HTR2A
10quinpirole45 2910.2DRD4, DRD3, DRD2, DRD1, HTR2A
11asenapine29 1110.1DRD2, HTR2A, DRD4, DRD3, DRD1
12aripiprazole29 45 51 24 1113.0HTR2A, DRD4, DRD3, DRD2, DRD1
13ziprasidone29 51 45 1112.0DRD3, DRD2, DRD1, HTR2A, DRD4
14chlorpromazine29 45 51 1112.0DRD1, BDNF, DRD2, DRD3, DRD4, HTR2A
15minaprine45 1110.0DRD1, SLC6A4, DRD2, MAOA, HTR2A
16loxapine29 45 1110.9DRD2, DRD4, HTR2A, DRD1
17pergolide45 29 1110.9DRD3, DRD4, COMT, HTR2A, DRD2, DRD1
18ropinirole45 119.9DRD1, DRD3, DRD4, COMT, HTR2A, DRD2
19cabergoline45 29 1110.9HTR2A, COMT, DRD4, DRD3, DRD1, DRD2
20dopac458.9COMT, MAOA, DRD3, DRD1, BDNF, DBH
21apomorphine29 45 1110.9HTR2A, DRD4, DRD2, DRD3, DRD1, COMT
22ketanserin45 299.9SLC6A4, BDNF, DRD1, DRD2, HTR2A
23bromocriptine45 29 1110.8DRD1, COMT, DRD4, DRD3, DRD2, HTR2A
24homovanillic acid45 249.7COMT, MAOA, BDNF, SLC6A4, DBH
25methylphenidate45 51 1110.7DRD4, DRD2, DRD1, SLC6A4, MAOA, COMT
26heroin45 51 1110.7COMT, DRD3, DRD2, BDNF, SLC6A4, DRD4
27pramipexole45 29 51 1111.6HTR2A, BDNF, COMT, DRD1, DRD2, DRD3
28mhpg458.6DBH, COMT, MAOA, DRD4, BDNF, SLC6A4
29fluvoxamine45 51 1110.6HTR2A, COMT, BDNF, MAOA, SLC6A4
30quetiapine45 51 29 24 1112.6DRD3, DRD2, DRD1, BDNF, SLC6A4, DRD4
31catecholamine458.6BDNF, DRD1, COMT, DBH, DRD4, DRD3
32haloperidol45 51 29 3 1112.5DRD2, DRD1, SLC6A4, DRD3, BDNF, DRD4
33imipramine45 29 51 24 1112.4SLC6A4, DBH, HTR2A, DRD3, DRD1, BDNF
34paroxetine45 51 29 1111.3HTR2A, COMT, MAOA, DRD4, BDNF, SLC6A4
35levodopa45 119.3BDNF, DBH, COMT, MAOA, DRD4, DRD3
366-hydroxydopamine458.2MAOA, COMT, DRD4, DRD3, DBH, DRD2
37cocaine45 119.2DBH, COMT, DRD4, DRD3, DRD2, DRD1
38gaba458.2SLC6A4, DRD2, DBH, MAOA, DRD4, DRD1
39clozapine45 29 51 1111.1SLC6A4, BDNF, DRD1, HTR2A, COMT, DRD4
40risperidone45 51 29 61 24 1113.1DRD1, DRD3, DRD4, COMT, HTR2A, DRD2
415-hydroxytryptamine458.1DRD2, DRD4, MAOA, SLC6A4, COMT, HTR2A
42methamphetamine45 51 1110.1COMT, MAOA, DRD4, DRD3, DRD2, DRD1
43mptp458.1DBH, COMT, MAOA, DRD2, DRD1, BDNF
44nicotine45 29 51 1111.0SLC6A4, DRD1, DRD2, DRD4, MAOA, COMT
45maoa457.9SLC6A4, BDNF, DRD2, DRD4, DBH, HTR2A
46epinephrine45 24 119.6BDNF, SLC6A4, DRD2, MAOA, COMT, DRD4
47olanzapine45 51 29 24 1111.5DRD3, SLC6A4, BDNF, INS, HTR2A, COMT
48dopamine45 29 24 1110.4BDNF, DRD1, DRD2, DRD3, DBH, HTR2A
49glutamate457.0DRD4, SLC6A4, INS, DBH, COMT, MAOA
50norepinephrine45 24 118.7INS, DBH, HTR2A, COMT, MAOA, DRD4

GO Terms for genes affiliated with Early-Onset Schizophrenia

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16Gene Ontology
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Cellular components related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6DBH, INS
2integral component of plasma membraneGO:0058877.5SLC6A4, TNF, HTR2A, DRD4, DRD3, DRD2
3plasma membraneGO:0058866.3YWHAH, TNF, HTR2A, COMT, DRD4, DRD3

Biological processes related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:04205310.3DRD4, DRD1
2fear responseGO:04259610.3DRD4, DBH
3regulation of locomotion involved in locomotory behaviorGO:09032510.3DRD2, DRD3
4negative regulation of dopamine receptor signaling pathwayGO:06016010.2DRD2, DRD3
5cerebral cortex GABAergic interneuron migrationGO:02185310.2DRD2, DRD1
6adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.2DRD3, DRD1
7regulation of cAMP metabolic processGO:03081410.2DRD2, DRD3
8positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.2DRD4, DRD2
9phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.2DRD2, DRD1
10negative regulation of voltage-gated calcium channel activityGO:190138610.2DRD2, DRD4
11peristalsisGO:03043210.2DRD2, DRD1
12maternal behaviorGO:04271110.2DBH, DRD1
13regulation of dopamine secretionGO:01405910.1DRD3, HTR2A
14striatum developmentGO:02175610.1DRD2, DRD1
15G-protein coupled receptor internalizationGO:00203110.1DRD3, DRD2
16regulation of dopamine uptake involved in synaptic transmissionGO:05158410.1DRD3, DRD2, DRD1
17negative regulation of synaptic transmission, glutamatergicGO:05196710.0HTR2A, DRD2
18positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.0DRD2, DRD1
19prepulse inhibitionGO:06013410.0DRD1, DRD2, DRD3
20behavioral fear responseGO:00166210.0DRD4, DRD1, BDNF
21response to histamineGO:03477610.0DRD4, DRD3, DRD2
22adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.0DRD2, DRD3, DRD4
23arachidonic acid secretionGO:05048210.0DRD4, DRD3, DRD2
24negative regulation of adenylate cyclase activityGO:00719410.0DRD4, DRD3, DRD2
25behavioral response to ethanolGO:04814910.0DBH, DRD4, DRD2
26neurotransmitter catabolic processGO:0421359.9MAOA, COMT
27positive regulation of renal sodium excretionGO:0358159.9DRD3, DRD2
28temperature homeostasisGO:0016599.9DRD1, DRD2, HTR2A
29locomotory behaviorGO:0076269.9DRD2, DRD3, DBH
30positive regulation of vasoconstrictionGO:0459079.8HTR2A, DBH
31grooming behaviorGO:0076259.8DRD2, DRD1
32social behaviorGO:0351769.8DRD4, DRD3, SLC6A4
33regulation of sodium ion transportGO:0020289.8DRD2, YWHAH
34dopamine metabolic processGO:0424179.8DRD4, DRD3, DRD2, DRD1
35synaptic transmission, dopaminergicGO:0019639.8DRD4, DRD3, DRD2, DRD1
36visual learningGO:0085429.7DBH, DRD3, DRD2, DRD1
37dopamine catabolic processGO:0424209.7DBH, COMT, MAOA
38cellular calcium ion homeostasisGO:0068749.6DRD2, DRD3, DRD4, HTR2A
39neurotransmitter biosynthetic processGO:0421369.6COMT, MAOA
40response to amphetamineGO:0019759.5DBH, DRD4, DRD3, DRD2, DRD1
41memoryGO:0076139.5SLC6A4, DRD1, HTR2A, DBH
42response to painGO:0482659.4COMT, DBH
43behavioral response to cocaineGO:0481489.4DRD1, DRD2, DRD3, DRD4, HTR2A
44negative regulation of protein secretionGO:0507099.4INS, DRD4, DRD3, DRD2
45positive regulation of ERK1 and ERK2 cascadeGO:0703749.2TNF, HTR2A, DRD2
46synaptic transmissionGO:0072689.2MAOA, COMT, HTR2A, DBH
47positive regulation of mitosisGO:0458409.2DRD3, TNF, INS
48negative regulation of lipid catabolic processGO:0509959.1INS, TNF
49response to hypoxiaGO:0016668.9TNF, DRD2, BDNF, SLC6A4
50response to drugGO:0424937.6TNF, HTR2A, DNMT3B, COMT, DRD3, DRD2

Molecular functions related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.0DRD1, DRD4
2potassium channel regulator activityGO:0154599.8DRD2, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.7DRD2, DRD3, DRD4
4dopamine bindingGO:0352409.5DRD1, DRD2, DRD3, DRD4
5insulin-like growth factor receptor bindingGO:0051599.3YWHAH, INS
6drug bindingGO:0081449.3HTR2A, DRD4, DRD3, DRD2
7identical protein bindingGO:0428028.3INS, TNF, DRD4, DRD2
8protein bindingGO:0055156.3INS, YWHAH, TNF, DNMT3B, DRD4, DRD3

Products for genes affiliated with Early-Onset Schizophrenia

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  • Antibodies
  • Proteins
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Sources for Early-Onset Schizophrenia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet