MCID: ERL020
MIFTS: 46

Early-Onset Schizophrenia malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

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Sources:
30ICD10 via Orphanet, 53Orphanet, 67UMLS
See all MalaCards sources

Aliases & Descriptions for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 53
 
Early Onset Schizophrenia 67

Classifications:



External Ids:

Orphanet53 ORPHA96369
ICD10 via Orphanet30 F20.8

Summaries for Early-Onset Schizophrenia

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MalaCards based summary: Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and kernicterus due to isoimmunization. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways are Neurotransmitter Clearance In The Synaptic Cleft and noradrenaline and adrenaline degradation. Affiliated tissues include brain, cortex and cingulate cortex, and related mouse phenotypes are no phenotypic analysis and skeleton.

Related Diseases for Early-Onset Schizophrenia

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Diseases in the Schizophrenia family:

Schizophrenia 17 Schizophrenia 16
Schizophrenia 10 Schizophrenia 4
Schizophrenia 15 early-onset schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia26.3BDNF, COMT, DBH, DRD1, DRD2, DRD3
2kernicterus due to isoimmunization10.5DRD2, HTR2A, NDUFS4
3vascular cancer10.4DRD2, HTR2A, NDUFS4
4basal cell carcinoma10.4DRD2, SLC6A4
5hemangioma of intra-abdominal structure10.4INS, TNF
6splenic disease10.4DRD2, HTR2A, SLC6A4
7gnathomiasis10.4DRD2, HTR2A, SOX10
8limb ischemia10.3BDNF, INS
9chagas disease10.3HTR2A, MAOA, SLC6A4
10brain meningioma10.3BDNF, COMT, DRD2
11neurodegeneration with optic atrophy, childhood onset10.2COMT, HTR2A, SLC6A4
12cocaine dependence10.2BDNF, DRD2, MAOA
13erysipelas10.2COMT, DRD2
14c8 deficiency, type ii10.2DRD1, DRD2, DRD4
15ovarian mucinous cystadenocarcinoma10.2BDNF, TH, TNF
16breast hemangioma10.2DRD1, DRD2
17anosognosia10.2COMT, DRD2, SLC6A4
18intrahepatic gall duct cancer10.2MAOA, SLC6A4
19braddock jones superneau syndrome10.2DBH, TH
20ring chromosome 14 syndrome10.2COMT, MAOA
21diabetic encephalopathy10.1HTR2A, INS, SLC6A4, TNF
22periampullary adenoma10.1HTR2A, INS, SLC6A4, TNF
23acute female pelvic peritonitis10.1DRD2, DRD4, MAOA
24laryngeal adductor paralysis10.1DRD4, HTR2A, SLC6A4
25lymphadenitis10.1BDNF, INS, MAOA, SLC6A4
26angiomyolipoma10.1BDNF, TH, TNF
27chronic intestinal vascular insufficiency10.1BDNF, INS, TH, TNF
28ulcerative colitis10.1BDNF, COMT, DRD2, SLC6A4
29acatalasemia10.1BDNF, COMT, HTR2A, SLC6A4
30pelvic inflammatory disease10.1DBH, DRD2, SLC6A4
31repetitive motion disorders10.1DBH, INS
32lymphosarcoma10.1BDNF, COMT, DRD2, SLC6A4
33rabies10.0HTR3A, MAOA, SLC6A4
34papillary serous adenocarcinoma10.0BDNF, HTR3A, TH
35bipolar disorder10.0
36conjunctival degeneration10.0HTR2A, SLC6A4
37bulbar polio10.0HTR3A, SLC6A4, TNF
38meckel's diverticulum10.0BDNF, COMT, MAOA, SLC6A4
39polycystic kidney disease 210.0DBH, DRD2, TH
40tongue disease9.9COMT, DRD2, MAOA, SLC6A4
41autoimmune-related retinopathy and optic neuropathy9.9HTR2A, HTR3A, SLC6A4
42cerebritis9.9
43neuronitis9.9
44dissociative disorder9.9DRD3, SLC6A4
45phaeohyphomycosis9.9BDNF, COMT, DRD1, HTR2A, SLC6A4
46idiopathic neonatal atrial flutter9.9HTR2A, HTR3A, MAOA, SLC6A4
47dysthymic disorder9.9BDNF, DRD4, HTR2A, INS, SLC6A4
48pervasive developmental disorder9.9BDNF, COMT, DRD4, SLC6A4
49autism spectrum disorder9.8
50vogt-koyanagi-harada disease9.8BDNF, COMT, HTR2A, MAOA, SLC6A4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to early-onset schizophrenia

Symptoms for Early-Onset Schizophrenia

About this section

Drugs & Therapeutics for Early-Onset Schizophrenia

About this section

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MolindoneapprovedPhase 427416-34-423897
Synonyms:
(+-)-Molindone
(+-)-molindone
15622-65-8 (mono-hydrochloride)
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
65973-37-7
7416-34-4
AB00514709
AC-7052
AC1L2N2H
AC1Q2SRY
AC1Q6J6B
BPBio1_001374
BRD-A65280694-003-03-8
BSPBio_001249
C07230
C16H24N2O2
CHEBI:103799
CHEMBL460
CID23897
D08226
DB01618
HSDB 3131
 
I14-11948
L001248
LS-83891
MOLINDONE
Moban
MolPort-005-940-887
Molindona
Molindona [INN-Spanish]
Molindona [inn-spanish]
Molindone
Molindone (INN)
Molindone (MOL)
Molindone Monohydrochloride
Molindone [INN:BAN]
Molindonum
Molindonum [INN-Latin]
Molindonum [inn-latin]
NCGC00162218-01
NCGC00162218-02
NCGC00162218-03
Oprea1_038890
Prestwick0_001035
Prestwick1_001035
Prestwick2_001035
Prestwick3_001035
SPBio_003100
UNII-RT3Y3QMF8N
2
Risperidoneapproved, investigationalPhase 4487106266-06-25073
Synonyms:
106266-06-2
3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
AB00514010
AC-1306
AC1L1JJU
BIDD:GT0262
BRD-K53857191-001-04-5
BRN 4891881
Belivon
Bio-0092
Buspirone
C23H27FN4O2
CAS-106266-06-2
CHEBI:8871
CHEMBL85
CID5073
CPD000466323
Consta, Risperdal
D00426
D018967
DB00734
EU-0101074
HMS1571M19
HMS2051H07
HMS2089C22
HSDB 7580
I01-1156
Jsp000573
KS-1106
L000510
LS-134196
Lopac-R-118
MLS000759429
MLS001165758
MLS001424081
MolPort-002-885-858
 
NCGC00015883-01
NCGC00015883-02
NCGC00015883-03
NCGC00094352-01
NCGC00094352-02
NCGC00094352-03
NCGC00179257-01
Prestwick0_001029
Prestwick1_001029
R 62 766
R 64 766, Risperdal, Risperidone
R 64,766
R 64766
R-118
R-64,766
R-64-766
R-64766
R64,766
R64766
Rispen
Risperdal
Risperdal (TN)
Risperdal Consta
Risperdal M-Tab
Risperidal
Risperidal M-Tab
Risperidona
Risperidona [Spanish]
Risperidone
Risperidone (JAN/USAN/INN)
Risperidone (RIS)
Risperidone [USAN:BAN:INN]
Risperidone, placebo
Risperidonum
Risperidonum [Latin]
Risperin
Rispolept
Rispolin
S1615_Selleck
SAM001246595
SMR000466323
SPBio_003078
STK646402
Sequinan
Spiron
TL8000230
UNII-L6UH7ZF8HC
risperdone
risperidone
3
Olanzapineapproved, investigationalPhase 4395132539-06-14585
Synonyms:
132539-06-1
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10 H -thieno[2,3- b ] [1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
AC-665
AC1L1IHS
AKOS000282888
ALKS-7921
BIDD:GT0332
BIDD:PXR0138
Bio-0169
C07322
C076029
C17H20N4S
CHEBI:7735
CHEMBL715
CID4585
CPD000466345
D00454
DB00334
Eli Lilly brand of olanzapine
HMS2051H05
HMS2089M04
HMS2093I04
I06-0784
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
Jsp001969
KS-1090
L000455
L005958
LS-152313
LY 170053
LY-170052
 
LY-170053
Lanzac
Lilly brand of olanzapine
MLS000759457
MLS001165781
MLS001195646
MLS001424057
Midax
MolPort-002-885-845
MolPort-003-666-569
MolPort-005-977-341
NCGC00096077-01
NCGC00096077-03
NCGC00096077-04
Olansek
Olanzapin
Olanzapina
Olanzapine
Olanzapine (JAN/USAN/INN)
Olanzapine (OLA)
Olanzapine [USAN:INN]
Olanzapinum
S2493_Selleck
SAM001246652
SMR000466345
SPECTRUM1505024
STK634338
Symbyax
TL8000772
UNII-N7U69T4SZR
Zalasta
Zydis
Zyprexa
Zyprexa (TN)
Zyprexa Intramuscular
Zyprexa Velotab
Zyprexa Zydis
olanzapina
olanzapine
olanzapinum
4
DopamineapprovedPhase 4, Phase 2375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
5AntiemeticsPhase 43888
6Peripheral Nervous System AgentsPhase 422776
7Serotonin AgentsPhase 4, Phase 23102
8Tranquilizing AgentsPhase 4, Phase 24164
9Serotonin Uptake InhibitorsPhase 41570
10Serotonin AntagonistsPhase 4, Phase 21381
11
SerotoninPhase 4, Phase 2356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
12Psychotropic DrugsPhase 4, Phase 26279
13Central Nervous System DepressantsPhase 4, Phase 212806
14Autonomic AgentsPhase 49774
15Neurotransmitter Uptake InhibitorsPhase 43464
16Dopamine AgentsPhase 4, Phase 23759
17Antipsychotic AgentsPhase 4, Phase 22359
18Dopamine AntagonistsPhase 4, Phase 21083
19Neurotransmitter AgentsPhase 4, Phase 217734
20Gastrointestinal AgentsPhase 48109
21Rho(D) Immune GlobulinPhase 3317
22Immunoglobulins, IntravenousPhase 3324
23gamma-GlobulinsPhase 3317
24ImmunoglobulinsPhase 36045
25AntibodiesPhase 36045
26
ZiprasidoneapprovedPhase 2145146939-27-760854
Synonyms:
138982-67-9 (hydrochloride monohydrate)
146939-27-7
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
6-chloro-5-[2-[4-(7-thia-8-azabicyclo[4.3.0]nona-1,3,5,8-tetraen-9-yl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one
AC1L1U27
Ambap122883-93-6
BIDD:GT0042
C07568
C21H21ClN4OS
CHEBI:10119
CHEMBL708
CID60854
CP 88059
CP 88059-01
CP-88,059
CP-88,059-01
CP-88,059-1
CP-88059-1
CPD000466328
D08687
DB00246
 
Geodon
Geodon Oral
I14-0766
L000659
LS-83744
MLS000759435
MolPort-003-850-885
SAM001246607
SMR000466328
TL8000889
UNII-6UKA5VEJ6X
Zeldox
Zipradon
Zipradon (TN)
Ziprasidona
Ziprasidone
Ziprasidone (INN)
Ziprasidone [INN:BAN]
Ziprasidone hydrochloride
Ziprasidone mesylate trihydrate
Ziprasidonum
ziprasidona
ziprasidonum
ziprazidone
27
Aripiprazoleapproved, investigational353129722-12-960795
Synonyms:
129722-12-9
24-29-3
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
AC-1554
AC1L1TXZ
AC1Q3T38
ALKS-9070
Abilify
Abilify (TN)
Abilify Discmelt
Abilitat
Aripiprazol
Aripiprazole
Aripiprazole (JAN/USAN/INN)
Aripiprazole [USAN]
Aripiprazolum
Aripirazole
Arpizol
Asprito|
BMS-337039
Bio-0004
Bristol-Myers Squibb brand of aripiprazole
C094645
C12564
C23H27Cl2N3O2
CHEBI:31236
CHEMBL1112
CID60795
CPD000466383
 
D01164
DB01238
Discmelt
FT-0082572
HMS2051I18
HMS2089M20
HMS2093F22
HSDB 7320
KS-1030
L001339
LS-142666
MLS000759517
MLS001165779
MLS001195621
MLS001424078
MolPort-002-885-808
MolPort-003-844-657
NCGC00159510-02
NCGC00159510-03
OPC 31
OPC-14597
OPC-31
Opc 14597
Otsuka brand of aripiprazole
Pripiprazole
S06-0010
SAM001246750
SMR000466383
STK625160
TL8000707
TL80090184
UNII-82VFR53I78
aripiprazol
aripiprazole
aripiprazolum
||OPC 14597

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS)CompletedNCT00053703Phase 4
2Efficacy Study of Early Onset of Antipsychotic Drug Action in SchizophreniaCompletedNCT00337662Phase 4
3Treatment With Risperidone Long Acting Injectable (RLAI) in an Early Phase of PsychosisCompletedNCT00369239Phase 4
45-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset SchizophreniaRecruitingNCT02435654Phase 4
5Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
6Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset PsychosisUnknown statusNCT00465920Phase 2
7Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic DisordersUnknown statusNCT02097563Phase 2
8Ziprasidone in Early Onset Schizophrenia Spectrum DisordersCompletedNCT01006551Phase 2
9Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS)CompletedNCT02764164
10Cognitive Remediation Therapy (CRT) in Adolescents With EOSCompletedNCT01701609
11Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission SchizophreniaCompletedNCT01781364
12Intensive Computerized Brain Training (ICBT) in Youth With Early Onset Psychosis (EOP)CompletedNCT01027962
13Sex Differences in Early Brain Development; Brain Development in Turner SyndromeCompletedNCT00877942
14Evaluating Genetic Risk Factors for Childhood-Onset SchizophreniaRecruitingNCT00001198
15Aripiprazole Treatment of the ProdromeTerminatedNCT00169949

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

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Anatomical Context for Early-Onset Schizophrenia

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MalaCards organs/tissues related to Early-Onset Schizophrenia:

35
Brain, Cortex, Cingulate cortex, Temporal lobe, Testes, Thalamus, Prefrontal cortex

Animal Models for Early-Onset Schizophrenia or affiliated genes

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MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

40 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7BDNF, DLG1, DNMT3B, DRD2, INS, TH
2MP:00053908.4DBH, DLG1, DNMT3B, DRD2, HTR2A, INS
3MP:00028738.3BDNF, DBH, DRD1, DRD2, INS, NDUFS4
4MP:00053888.2BDNF, COMT, DLG1, DRD1, DRD2, NDUFS4
5MP:00053758.1DBH, DRD1, DRD2, DRD3, INS, TNF
6MP:00053848.1BDNF, DLG1, DNMT3B, DRD1, DRD2, INS
7MP:00053897.9BDNF, COMT, DLG1, DNMT3B, DRD2, HTR3A
8MP:00053697.8DLG1, DRD1, DRD2, HTR2A, HTR3A, INS
9MP:00053917.6BDNF, DBH, DLG1, DNMT3B, DRD1, DRD4
10MP:00053817.6BDNF, DLG1, DRD1, DRD2, DRD3, HTR2A
11MP:00107717.2BDNF, DBH, DRD1, DRD2, HTR3A, INS
12MP:00053856.6COMT, DBH, DNMT3B, DRD1, DRD2, DRD3
13MP:00053796.3BDNF, COMT, DBH, DLG1, DNMT3B, DRD2
14MP:00107685.7BDNF, DBH, DLG1, DNMT3B, DRD1, DRD2
15MP:00053785.7BDNF, DBH, DLG1, DNMT3B, DRD1, DRD2
16MP:00053764.7BDNF, COMT, DBH, DLG1, DRD1, DRD2
17MP:00053864.6BDNF, COMT, DBH, DLG1, DRD1, DRD2
18MP:00036314.5BDNF, COMT, DBH, DLG1, DNMT3B, DRD1

Publications for Early-Onset Schizophrenia

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Articles related to Early-Onset Schizophrenia:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
Time perception of simultaneous and sequential events in early-onset schizophrenia. (27388526)
2016
2
Altered expression of mRNA profiles in blood of early-onset schizophrenia. (26733343)
2016
3
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. (26916502)
2016
4
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. (27384868)
2016
5
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. (26001923)
2015
6
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. (25840049)
2015
7
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. (25130214)
2014
8
Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial. (25062593)
2014
9
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. (25520226)
2014
10
Systematic review of the efficacy and tolerability of Clozapine in the treatment of youth with early onset schizophrenia. (24119631)
2014
11
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study. (24831926)
2014
12
Relative stability of neurocognitive deficits in early onset schizophrenia spectrum patients. (24811433)
2014
13
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
14
Aberrant default mode functional connectivity in early onset schizophrenia. (23923052)
2013
15
Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings. (24012081)
2013
16
Changes in the diagnosed incidence of early onset schizophrenia over four decades. (22906158)
2013
17
Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report. (23714054)
2013
18
Visual backward-masking performance in a longitudinal study of early onset schizophrenia. (22673182)
2012
19
Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities. (22917502)
2012
20
Early-onset schizophrenia. (22797279)
2012
21
A meta-analysis of neuropsychological functioning in patients with early onset schizophrenia and pediatric bipolar disorder. (21391023)
2011
22
Brain functional connectivity of functional magnetic resonance imaging of patients with early-onset schizophrenia. (20130360)
2010
23
Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study. (20494268)
2010
24
Deficient maturation of aspects of attention and executive functions in early onset schizophrenia. (20680364)
2010
25
Neurocognition in early-onset schizophrenia and schizoaffective disorders. (20215926)
2010
26
The use of aripiprazole in early onset schizophrenia: safety and efficacy. (20527278)
2009
27
Aripiprazole as an adjunct to clozapine therapy in adolescents with early-onset schizophrenia: a retrospective chart review. (19585394)
2009
28
Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia. (19641111)
2009
29
Dichotic listening impairments in early onset schizophrenia are associated with reduced left temporal lobe volume. (19423299)
2009
30
The Maudsley early onset schizophrenia study: cognitive function over a 4-year follow-up period. (18024468)
2008
31
The psychopathological and psychosocial outcome of early-onset schizophrenia: preliminary data of a 13-year follow-up. (18304312)
2008
32
Long-term sustained benefits of clozapine treatment in refractory early onset schizophrenia: a retrospective study in Korean children and adolescents. (18814190)
2008
33
Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. (16920078)
2007
34
Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test. (16309895)
2006
35
Antipsychotics in early onset Schizophrenia: Systematic review and meta-analysis. (16470340)
2006
36
White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. (16113622)
2005
37
Interaction of tumor necrosis alpha - G308A and epidermal growth factor gene polymorphisms in early-onset schizophrenia. (15614591)
2005
38
Risk for early-onset schizophrenia assessed via gray-matter distributions. (16779211)
2005
39
Normal cerebral volume asymmetries in early onset schizophrenia. (14732594)
2004
40
Attenuation of perceptual asymmetries in patients with early-onset schizophrenia: evidence in favour of reduced hemispheric differentiation in schizophrenia? (15382732)
2004
41
Early-onset schizophrenia in children with mental retardation: diagnostic reliability and stability of clinical features. (12544175)
2003
42
Brain volume, asymmetry and intellectual impairment in relation to sex in early-onset schizophrenia. (12893664)
2003
43
Associations between premorbid intellectual performance, early-life exposures and early-onset schizophrenia. Cohort study. (12356656)
2002
44
Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. (11481166)
2001
45
Structural magnetic imaging of the hippocampus in early onset schizophrenia. (11343679)
2001
46
Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia? (9444905)
1998
47
Liaison between adolescent and adult services in early-onset schizophrenia. (9747420)
1998
48
Is a child's risk of early onset schizophrenia increased in the highest social class? (9075303)
1997
49
A preliminary study on early onset schizophrenia and bipolar disorder: large polyglutamine expansions are not involved. (9335205)
1997
50
A chart review study of late-onset and early-onset schizophrenia. (2574011)
1989

Variations for Early-Onset Schizophrenia

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Expression for genes affiliated with Early-Onset Schizophrenia

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Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for genes affiliated with Early-Onset Schizophrenia

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Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8COMT, MAOA
2
Show member pathways
9.8COMT, MAOA
39.7BDNF, SOX10, TH
49.4COMT, MAOA, TH
59.2DRD3, DRD4, HTR2A
6
Show member pathways
9.1BDNF, DRD1, DRD2, MAOA, TH
79.0DRD1, DRD2, DRD3, DRD4
8
Show member pathways
9.0COMT, DBH, MAOA, TH
9
Show member pathways
9.0COMT, DBH, MAOA, TH
10
Show member pathways
8.9DRD2, DRD3, DRD4, TH
118.8HTR2A, HTR3A, MAOA, SLC6A4
12
Show member pathways
8.8DRD1, DRD2, DRD3, DRD4, HTR2A
13
Show member pathways
8.8DBH, MAOA, SLC6A4, TH, TNF
14
Show member pathways
8.0BDNF, DRD1, DRD2, DRD3, DRD4, INS
15
Show member pathways
7.9BDNF, DNMT3B, DRD1, DRD2, INS, MAOA
167.5BDNF, HTR2A, HTR3A, MAOA, SLC6A4, TH
17
Show member pathways
6.6COMT, DRD1, DRD2, DRD3, DRD4, HTR2A

GO Terms for genes affiliated with Early-Onset Schizophrenia

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Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:003477410.2DBH, INS
2neuronal cell bodyGO:00430258.6DRD1, DRD4, HTR2A, HTR3A, TH
3integral component of plasma membraneGO:00058878.2DRD1, DRD2, DRD3, DRD4, HTR2A, SLC6A4
4axonGO:00304248.2COMT, DRD2, HTR2A, HTR3A, TH

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1orbitofrontal cortex developmentGO:002176910.5DRD1, DRD2
2cellular response to nicotineGO:007131610.5TH, TNF
3cerebral cortex GABAergic interneuron migrationGO:002185310.5DRD1, DRD2
4negative regulation of circadian sleep/wake cycle, sleepGO:004232110.4DRD1, DRD2
5negative regulation of synaptic transmission, glutamatergicGO:005196710.4DRD2, HTR2A
6mating behaviorGO:000761710.4DRD1, TH
7neurotransmitter catabolic processGO:004213510.4COMT, MAOA
8negative regulation of voltage-gated calcium channel activityGO:190138610.3DRD2, DRD4
9temperature homeostasisGO:000165910.3DRD1, DRD2, HTR2A
10synapse assemblyGO:000741610.3BDNF, DRD1, DRD2
11norepinephrine biosynthetic processGO:004242110.2DBH, TH
12catecholamine biosynthetic processGO:004242310.2DBH, TH
13positive regulation of dopamine uptake involved in synaptic transmissionGO:005158610.2DRD2, DRD4
14response to activityGO:001482310.2DNMT3B, DRD1, TH
15response to nicotineGO:003509410.1DRD1, DRD2, TH
16fear responseGO:004259610.1DBH, DRD4
17response to steroid hormoneGO:004854510.1DRD1, DRD4, TH
18peristalsisGO:00304329.9DLG1, DRD1, DRD2
19associative learningGO:00083069.9DBH, DRD1, DRD2
20negative regulation of dopamine receptor signaling pathwayGO:00601609.9DRD2, DRD3
21dopamine catabolic processGO:00424209.9COMT, DBH, MAOA
22response to estradiolGO:00323559.9DNMT3B, DRD1, SLC6A4, TH
23acid secretionGO:00467179.9DRD2, DRD3
24regulation of locomotion involved in locomotory behaviorGO:00903259.9DRD2, DRD3
25regulation of cAMP metabolic processGO:00308149.8DRD2, DRD3
26behavioral response to ethanolGO:00481499.8DBH, DRD2, DRD4
27regulation of dopamine secretionGO:00140599.8DRD2, DRD3, HTR2A
28regulation of dopamine uptake involved in synaptic transmissionGO:00515849.8DRD1, DRD2, DRD3
29response to hypoxiaGO:00016669.7DNMT3B, DRD2, SLC6A4, TH
30response to morphineGO:00432789.6DRD1, DRD2, DRD3
31response to histamineGO:00347769.6DRD2, DRD3, DRD4
32negative regulation of adenylate cyclase activityGO:00071949.5DRD2, DRD3, DRD4
33memoryGO:00076139.4DBH, DRD1, HTR2A, SLC6A4, TH
34negative regulation of protein kinase B signalingGO:00518989.4DLG1, DRD2, DRD3
35dopamine receptor signaling pathwayGO:00072129.3DRD1, DRD2, DRD3, DRD4
36negative regulation of protein secretionGO:00507099.3DRD2, DRD3, DRD4, INS
37arachidonic acid secretionGO:00504829.3DRD2, DRD3, DRD4
38learningGO:00076129.3COMT, DRD1, DRD3, TH
39visual learningGO:00085429.2DBH, DRD1, DRD2, DRD3
40adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00071959.2DRD2, DRD3, DRD4
41behavioral response to cocaineGO:00481489.1DRD1, DRD2, DRD3, DRD4, HTR2A
42prepulse inhibitionGO:00601349.1DRD1, DRD2, DRD3
43synaptic transmission, dopaminergicGO:00019639.0DRD1, DRD2, DRD3, DRD4, TH
44social behaviorGO:00351768.6DRD1, DRD3, DRD4, SLC6A4, TH
45response to cocaineGO:00422208.6DNMT3B, DRD1, DRD2, DRD3, HTR3A
46locomotory behaviorGO:00076268.6DBH, DRD1, DRD2, DRD3, TH
47dopamine metabolic processGO:00424178.5COMT, DRD1, DRD2, DRD3, DRD4
48response to amphetamineGO:00019758.4DBH, DRD1, DRD2, DRD3, DRD4, TH
49response to ethanolGO:00454718.4DRD1, DRD2, DRD3, HTR3A, TH
50response to drugGO:00424938.2COMT, DNMT3B, DRD1, DRD2, DRD3, HTR2A

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.2INS, YWHAH
2serotonin bindingGO:00513789.6HTR2A, HTR3A, MAOA
3dopamine neurotransmitter receptor activity, coupled via GsGO:00015889.3DRD1, DRD3, DRD4
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015918.9DRD2, DRD3, DRD4
5dopamine neurotransmitter receptor activityGO:00049528.9DRD1, DRD2, DRD3, DRD4
6drug bindingGO:00081448.8DRD1, DRD2, DRD3, DRD4, HTR2A
7dopamine bindingGO:00352408.6DRD1, DRD2, DRD3, DRD4, TH

Sources for Early-Onset Schizophrenia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet