MCID: ERL020
MIFTS: 39

Early-Onset Schizophrenia malady

Neuronal diseases, Ear diseases categories

Summaries for Early-Onset Schizophrenia

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MalaCards: Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and bipolar disorder. An important gene associated with Early-Onset Schizophrenia is DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta), and among its related pathways are phenylalanine utilization and Hypothetical Network for Drug Addiction. The compounds eticlopride and (+)-butaclamol have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and vision/eye.

Aliases & Classifications for Early-Onset Schizophrenia

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48Orphanet, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Ear diseases


Aliases & Descriptions:

early-onset schizophrenia 48
early onset schizophrenia 60


Related Diseases for Early-Onset Schizophrenia

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17GeneCards, 18GeneDecks
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Diseases in the Schizophrenia family:

Schizophrenia 4 Schizophrenia 12
Schizophrenia 17 Schizophrenia 14
Schizophrenia 16 Schizophrenia 13
Schizophrenia 10 Schizophrenia 15
early-onset schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.8DRD3, HTR2A, COMT
2bipolar disorder30.5BDNF, SLC6A4
3neuroleptic malignant syndrome30.1DRD2
4schizoaffective disorder30.1SLC6A4, COMT, BDNF, HTR2A, DRD2, DRD3
5attention deficit hyperactivity disorder30.1DRD2, DRD4, MAOA, DBH, SLC6A4, DRD1
6obsessive-compulsive disorder30.0COMT, BDNF, HTR3A, HTR2A, DRD1, DRD2
7psychotic disorder30.0COMT, BDNF, HTR3A, HTR2A, DRD1, DRD2
8alzheimer's disease30.0COMT, BDNF, HTR2A, DRD1, DRD2, DRD3
9cerebritis10.3
10neuronitis10.3
11autism spectrum disorder10.2
12mitochondrial disorders10.2
13periventricular leukomalacia10.1
14parametritis10.1
15childhood-onset schizophrenia10.1
16lung cancer10.0DNMT3B
17myoclonus-dystonia10.0DRD2
18wilson disease10.0DRD2
19melancholia10.0MAOA
20dyspepsia10.0HTR3A
21paranoid schizophrenia10.0COMT
22leiomyoma10.0COMT
23hepatic encephalopathy10.0MAOA
24striatonigral degeneration10.0DRD2
25amyotrophic lateral sclerosis10.0BDNF
26endometriosis10.0COMT
27heroin dependence10.0DRD2, DRD4
28focal dystonia10.0DRD2
29leukodystrophy10.0SOX10
30gilles de la tourette syndrome10.0DRD4, DRD2
31restless legs syndrome10.0HTR3A, DRD2
32multiple system atrophy10.0DRD2, DBH
33choriocarcinoma10.0SLC6A4
34delusional disorder10.0DRD2, DRD4
35blindness10.0INS
36obsessive-compulsive personality disorder10.0SLC6A4
37alcoholic psychosis10.0SLC6A4
38fragile x syndrome10.0SLC6A4
39polycystic ovary syndrome10.0INS
40neuroblastoma10.0DBH, BDNF
41hepatitis10.0DBH, COMT
42opiate dependence10.0DRD2, DRD3
43adenocarcinoma10.0DNMT3B, BDNF
44hyperuricemia10.0INS
45pancreatitis10.0INS
46motor neuron disease10.0BDNF
47irritable bowel syndrome10.0HTR3A, SLC6A4
48duodenal ulcer10.0INS
49dysthymic disorder10.0HTR2A, MAOA
50riley-day syndrome10.0BDNF, DBH

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to early-onset schizophrenia

Clinical Features for Early-Onset Schizophrenia

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Drugs & Therapeutics for Early-Onset Schizophrenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Early-Onset Schizophrenia

Drug clinical trials:

Search ClinicalTrials for Early-Onset Schizophrenia

Search NIH Clinical Center for Early-Onset Schizophrenia

Search CenterWatch for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

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Anatomical Context for Early-Onset Schizophrenia

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Animal Models for Early-Onset Schizophrenia or affiliated genes

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36MGI
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Publications for Early-Onset Schizophrenia

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Genetic Variations for Early-Onset Schizophrenia

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Expression for genes affiliated with Early-Onset Schizophrenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for genes affiliated with Early-Onset Schizophrenia

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN, 49PharmGKB, 53Reactome
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Pathways related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8MAOA, COMT
29.7DRD1, DRD2, DRD4
39.6DRD4, DRD3, HTR2A
4
Tyrosine metabolism p.1 (dopamine)
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9.6DBH, MAOA, COMT
5
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9.6COMT, MAOA, DBH
69.4DRD1, DRD2, DRD3, DRD4
7
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9.4DRD1, DRD2, DRD3, DRD4
89.4DRD1, DRD2, DRD3, DRD4
9
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9.2BDNF, DRD1, DRD2, MAOA
109.1TNF, DBH, SLC6A4
11
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9.1HTR2A, DRD1, DRD2, DRD3, DRD4
12
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8.6BDNF, TNF, DRD1, DRD2, MAOA
13
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8.0SLC6A4, HTR3A, HTR2A, DRD1, DRD2, DRD3
14
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8.0BDNF, DRD1, DRD2, DRD3, DRD4, YWHAH
15
Hide members
7.7COMT, HTR3A, HTR2A, DRD1, DRD2, DRD3
167.5BDNF, TNF, HTR3A, HTR2A, MAOA, YWHAH

Compounds for genes affiliated with Early-Onset Schizophrenia

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28IUPHAR, 44Novoseek, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show top 50)    (show all 263)
idCompoundScoreTop Affiliating Genes
1eticlopride28 4410.6DRD1, DRD2, DRD3, DRD4
2(+)-butaclamol28 4410.4DRD3, DRD2, DRD1, HTR2A, DRD4
3benzamide44 210.4HTR3A, DRD2, DRD3, DRD4, MAOA
4raclopride44 2810.4DRD4, HTR2A, DRD1, DRD2, DRD3
5amine449.3COMT, HTR3A, DRD3, MAOA, DBH
6bromocriptine28 44 1111.3DRD4, DRD3, HTR2A, COMT, DRD1
7lisuride28 44 1111.2DRD4, DRD1, DRD2, DRD3, HTR2A
8spiperone28 4410.2HTR2A, HTR3A, DRD2, DRD4, DRD1, DRD3
9iloperidone49 44 28 1112.2DRD1, DRD2, DRD3, DRD4, HTR3A, HTR2A
10minaprine44 1110.1HTR2A, DRD1, DRD2, MAOA, SLC6A4
11aripiprazole28 49 44 11 2413.1DRD4, DRD1, DRD3, HTR3A, DRD2, HTR2A
12paliperidone44 1110.1DRD3, DRD2, DRD1, HTR2A, DRD4
13ziprasidone49 28 44 1112.1HTR2A, HTR3A, DRD1, DRD2, DRD3, DRD4
14ropinirole44 1110.1DRD4, DRD2, DRD3, HTR2A, COMT, DRD1
15pergolide28 44 1111.1DRD3, DRD4, DRD2, COMT, DRD1, HTR2A
16cabergoline28 44 1111.1COMT, HTR2A, DRD1, DRD2, DRD3, DRD4
17Methotrimeprazine119.1HTR2A, DRD1, DRD4, DRD3, DRD2
18asenapine28 1110.1DRD4, DRD3, DRD1, HTR2A, DRD2
19dopac449.1DBH, MAOA, DRD3, DRD1, COMT, BDNF
20ketanserin28 4410.0HTR3A, SLC6A4, DRD2, HTR2A, BDNF
21apomorphine44 28 1111.0DRD2, DRD1, HTR2A, DRD4, COMT, DRD3
22methylphenidate44 49 1111.0COMT, DRD1, SLC6A4, MAOA, DRD4, DRD2
23quinpirole44 2810.0DRD4, DRD3, DRD1, DRD2, HTR2A
24mhpg448.9COMT, MAOA, BDNF, DRD4, SLC6A4, DBH
25homovanillic acid44 249.8COMT, MAOA, DBH, SLC6A4, BDNF
26quetiapine44 49 28 11 2412.8HTR2A, DRD1, DRD4, DRD3, BDNF, DRD2
27chlorpromazine44 28 49 1111.8DRD4, HTR3A, DRD3, DRD2, DRD1, BDNF
28pramipexole44 49 28 1111.8COMT, BDNF, DRD1, DRD2, DRD3, DRD4
29catecholamine448.7MAOA, DBH, COMT, BDNF, DRD1, DRD3
30fluoxetine49 44 28 1111.6DRD2, HTR2A, SLC6A4, HTR3A, MAOA, BDNF
31nicotine44 49 28 1111.4MAOA, DBH, COMT, DRD1, DRD3, DRD4
32glutamate448.4SLC6A4, COMT, DRD4, DRD3, DRD2, DRD1
33methamphetamine44 49 1110.4SLC6A4, MAOA, DRD4, DRD3, DRD2, DRD1
34cocaine44 119.3DBH, DRD4, DRD3, DRD2, DRD1, BDNF
35imipramine44 49 28 11 2412.3MAOA, DRD3, DRD1, HTR2A, HTR3A, BDNF
36fluvoxamine44 49 1110.3BDNF, MAOA, SLC6A4, HTR2A, HTR3A
37levodopa44 119.3DBH, MAOA, DRD4, DRD3, DRD2, DRD1
386-hydroxydopamine448.3DBH, MAOA, DRD4, DRD3, DRD2, DRD1
39haloperidol44 28 2 49 1112.3DRD2, SLC6A4, DRD3, DRD1, HTR2A, DRD4
405-hydroxytryptamine448.3COMT, HTR2A, HTR3A, SLC6A4, DRD2, DRD4
41gaba448.2HTR3A, SLC6A4, DBH, MAOA, BDNF, DRD1
42paroxetine44 49 28 1111.2COMT, BDNF, HTR3A, HTR2A, DRD3, SLC6A4
43maoa448.2SLC6A4, DBH, MAOA, DRD4, DRD2, HTR2A
44mptp448.1NDUFS4, BDNF, COMT, DRD1, DRD2, DRD3
45clozapine44 28 49 1111.0COMT, BDNF, HTR3A, HTR2A, DRD2, DRD3
46risperidone28 44 49 59 11 2413.0DRD3, COMT, BDNF, HTR3A, DRD1, DRD2
47olanzapine49 44 28 11 2412.0COMT, INS, BDNF, HTR3A, HTR2A, DRD1
48epinephrine44 11 249.8MAOA, DRD2, SLC6A4, DBH, INS, BDNF
49dopamine44 28 11 2410.2SLC6A4, DBH, MAOA, DRD4, DRD3, DRD2
50norepinephrine44 11 248.7SLC6A4, INS, DBH, MAOA, DRD4, DRD3

GO Terms for genes affiliated with Early-Onset Schizophrenia

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16Gene Ontology
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Cellular components related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.7INS, DBH
2integral to plasma membraneGO:0058877.6SLC6A4, TNF, HTR3A, HTR2A, DRD1, DRD2
3plasma membraneGO:0058866.5COMT, TNF, HTR3A, HTR2A, DRD1, DRD2

Biological processes related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1fear responseGO:04259610.3DBH, DRD4
2negative regulation of voltage-gated calcium channel activityGO:190138610.3DRD2, DRD4
3regulation of dopamine metabolic processGO:04205310.3DRD1, DRD4
4positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.3DRD2, DRD4
5cerebral cortex GABAergic interneuron migrationGO:02185310.3DRD2, DRD1
6negative regulation of dopamine receptor signaling pathwayGO:06016010.3DRD2, DRD3
7phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.2DRD1, DRD2
8regulation of cAMP metabolic processGO:03081410.2DRD3, DRD2
9peristalsisGO:03043210.2DRD1, DRD2
10adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.2DRD1, DRD3
11neurotransmitter catabolic processGO:04213510.1COMT, MAOA
12regulation of dopamine uptake involved in synaptic transmissionGO:05158410.1DRD1, DRD2, DRD3
13G-protein coupled receptor internalizationGO:00203110.1DRD2, DRD3
14response to histamineGO:03477610.1DRD4, DRD3, DRD2
15prepulse inhibitionGO:06013410.1DRD3, DRD2, DRD1
16behavioral response to ethanolGO:04814910.1DBH, DRD4, DRD2
17adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD4, DRD3, DRD2
18arachidonic acid secretionGO:05048210.1DRD4, DRD3, DRD2
19elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1DRD1, DRD2
20serotonin receptor signaling pathwayGO:00721010.1HTR3A, HTR2A
21negative regulation of synaptic transmission, glutamatergicGO:05196710.1DRD2, HTR2A
22negative regulation of adenylate cyclase activityGO:00719410.0DRD4, DRD3, DRD2
23response to cocaineGO:04222010.0HTR3A, DRD2, DRD3
24behavioral fear responseGO:00166210.0DRD4, DRD1, BDNF
25dopamine catabolic processGO:04242010.0COMT, MAOA, DBH
26temperature homeostasisGO:00165910.0DRD2, DRD1, HTR2A
27locomotory behaviorGO:00762610.0DBH, DRD3, DRD2
28regulation of dopamine secretionGO:0140599.9HTR2A, DRD2, DRD3
29positive regulation of renal sodium excretionGO:0358159.9DRD2, DRD3
30dopamine metabolic processGO:0424179.9DRD1, DRD2, DRD3, DRD4
31behavioral response to cocaineGO:0481489.9DRD1, DRD2, DRD3, DRD4
32synaptic transmission, dopaminergicGO:0019639.9DRD1, DRD2, DRD3, DRD4
33social behaviorGO:0351769.9SLC6A4, DRD4, DRD3
34visual learningGO:0085429.9DRD1, DRD2, DRD3, DBH
35neurotransmitter biosynthetic processGO:0421369.8MAOA, COMT
36circadian regulation of gene expressionGO:0329229.8DRD2, DRD3
37regulation of sodium ion transportGO:0020289.8DRD2, YWHAH
38cellular calcium ion homeostasisGO:0068749.7HTR2A, DRD2, DRD3, DRD4
39grooming behaviorGO:0076259.7DRD1, DRD2
40response to amphetamineGO:0019759.6DBH, DRD4, DRD3, DRD2, DRD1
41memoryGO:0076139.6HTR2A, DRD1, DBH, SLC6A4
42negative regulation of protein secretionGO:0507099.6DRD2, DRD3, DRD4, INS
43positive regulation of mitosisGO:0458409.4TNF, DRD3, INS
44negative regulation of lipid catabolic processGO:0509959.4TNF, INS
45positive regulation of ERK1 and ERK2 cascadeGO:0703749.4DRD2, HTR2A, TNF
46synaptic transmissionGO:0072689.2COMT, HTR3A, HTR2A, MAOA, DBH
47response to hypoxiaGO:0016669.0BDNF, TNF, DRD2, SLC6A4
48response to drugGO:0424938.3COMT, TNF, HTR2A, DRD1, DRD2, DRD3

Molecular functions related to Early-Onset Schizophrenia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.0DRD1, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.8DRD2, DRD3, DRD4
3dopamine bindingGO:0352409.6DRD4, DRD3, DRD2, DRD1
4serotonin bindingGO:0513789.5HTR2A, HTR3A
5insulin-like growth factor receptor bindingGO:0051599.4INS, YWHAH
6drug bindingGO:0081449.4DRD4, DRD3, DRD2, HTR2A
7identical protein bindingGO:0428027.9SOX10, TNF, DRD2, DRD4, INS

Products for genes affiliated with Early-Onset Schizophrenia

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Sources for Early-Onset Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet