MCID: ERL020
MIFTS: 46

Early-Onset Schizophrenia malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

About this section
Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 54
 
Early Onset Schizophrenia 68

Classifications:



External Ids:

Orphanet54 ORPHA96369
ICD10 via Orphanet31 F20.8

Summaries for Early-Onset Schizophrenia

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MalaCards based summary: Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and kernicterus due to isoimmunization. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways are Neurotransmitter Clearance In The Synaptic Cleft and noradrenaline and adrenaline degradation. Affiliated tissues include brain, cortex and cingulate cortex, and related mouse phenotypes are shRNA abundance <= 50% and no phenotypic analysis.

Related Diseases for Early-Onset Schizophrenia

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Diseases in the Schizophrenia family:

Schizophrenia 17 Schizophrenia 16
Schizophrenia 10 Schizophrenia 4
Schizophrenia 15 early-onset schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia26.3BDNF, COMT, DBH, DRD1, DRD2, DRD3
2kernicterus due to isoimmunization10.5DRD2, HTR2A, NDUFS4
3vascular cancer10.4DRD2, HTR2A, NDUFS4
4basal cell carcinoma10.4DRD2, SLC6A4
5hemangioma of intra-abdominal structure10.4INS, TNF
6splenic disease10.4DRD2, HTR2A, SLC6A4
7gnathomiasis10.4DRD2, HTR2A, SOX10
8limb ischemia10.3BDNF, INS
9chagas disease10.3HTR2A, MAOA, SLC6A4
10brain meningioma10.3BDNF, COMT, DRD2
11neurodegeneration with optic atrophy, childhood onset10.2COMT, HTR2A, SLC6A4
12cocaine dependence10.2BDNF, DRD2, MAOA
13erysipelas10.2COMT, DRD2
14c8 deficiency, type ii10.2DRD1, DRD2, DRD4
15ovarian mucinous cystadenocarcinoma10.2BDNF, TH, TNF
16breast hemangioma10.2DRD1, DRD2
17anosognosia10.2COMT, DRD2, SLC6A4
18intrahepatic gall duct cancer10.2MAOA, SLC6A4
19braddock jones superneau syndrome10.2DBH, TH
20ring chromosome 14 syndrome10.2COMT, MAOA
21diabetic encephalopathy10.1HTR2A, INS, SLC6A4, TNF
22periampullary adenoma10.1HTR2A, INS, SLC6A4, TNF
23acute female pelvic peritonitis10.1DRD2, DRD4, MAOA
24laryngeal adductor paralysis10.1DRD4, HTR2A, SLC6A4
25lymphadenitis10.1BDNF, INS, MAOA, SLC6A4
26angiomyolipoma10.1BDNF, TH, TNF
27chronic intestinal vascular insufficiency10.1BDNF, INS, TH, TNF
28ulcerative colitis10.1BDNF, COMT, DRD2, SLC6A4
29acatalasemia10.1BDNF, COMT, HTR2A, SLC6A4
30pelvic inflammatory disease10.1DBH, DRD2, SLC6A4
31repetitive motion disorders10.1DBH, INS
32lymphosarcoma10.1BDNF, COMT, DRD2, SLC6A4
33rabies10.0HTR3A, MAOA, SLC6A4
34papillary serous adenocarcinoma10.0BDNF, HTR3A, TH
35bipolar disorder10.0
36conjunctival degeneration10.0HTR2A, SLC6A4
37bulbar polio10.0HTR3A, SLC6A4, TNF
38meckel's diverticulum10.0BDNF, COMT, MAOA, SLC6A4
39polycystic kidney disease 210.0DBH, DRD2, TH
40tongue disease9.9COMT, DRD2, MAOA, SLC6A4
41autoimmune-related retinopathy and optic neuropathy9.9HTR2A, HTR3A, SLC6A4
42cerebritis9.9
43neuronitis9.9
44dissociative disorder9.9DRD3, SLC6A4
45phaeohyphomycosis9.9BDNF, COMT, DRD1, HTR2A, SLC6A4
46idiopathic neonatal atrial flutter9.9HTR2A, HTR3A, MAOA, SLC6A4
47dysthymic disorder9.9BDNF, DRD4, HTR2A, INS, SLC6A4
48pervasive developmental disorder9.9BDNF, COMT, DRD4, SLC6A4
49autism spectrum disorder9.8
50vogt-koyanagi-harada disease9.8BDNF, COMT, HTR2A, MAOA, SLC6A4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to early-onset schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

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GenomeRNAi Phenotypes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00343-S7.1COMT, DLG1, DRD1, DRD2, DRD3, DRD4

MGI Mouse Phenotypes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

41 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7BDNF, DLG1, DNMT3B, DRD2, INS, TH
2MP:00053908.4DBH, DLG1, DNMT3B, DRD2, HTR2A, INS
3MP:00028738.3BDNF, DBH, DRD1, DRD2, INS, NDUFS4
4MP:00053888.2BDNF, COMT, DLG1, DRD1, DRD2, NDUFS4
5MP:00053758.1DBH, DRD1, DRD2, DRD3, INS, TNF
6MP:00053848.1BDNF, DLG1, DNMT3B, DRD1, DRD2, INS
7MP:00053897.9BDNF, COMT, DLG1, DNMT3B, DRD2, HTR3A
8MP:00053697.8DLG1, DRD1, DRD2, HTR2A, HTR3A, INS
9MP:00053917.6BDNF, DBH, DLG1, DNMT3B, DRD1, DRD4
10MP:00053817.6BDNF, DLG1, DRD1, DRD2, DRD3, HTR2A
11MP:00107717.2BDNF, DBH, DRD1, DRD2, HTR3A, INS
12MP:00053856.6COMT, DBH, DNMT3B, DRD1, DRD2, DRD3
13MP:00053796.3BDNF, COMT, DBH, DLG1, DNMT3B, DRD2
14MP:00107685.7BDNF, DBH, DLG1, DNMT3B, DRD1, DRD2
15MP:00053785.7BDNF, DBH, DLG1, DNMT3B, DRD1, DRD2
16MP:00053764.7BDNF, COMT, DBH, DLG1, DRD1, DRD2
17MP:00053864.6BDNF, COMT, DBH, DLG1, DRD1, DRD2
18MP:00036314.5BDNF, COMT, DBH, DLG1, DNMT3B, DRD1

Drugs & Therapeutics for Early-Onset Schizophrenia

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Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MolindoneapprovedPhase 427416-34-423897
Synonyms:
(+-)-Molindone
(+-)-molindone
15622-65-8 (mono-hydrochloride)
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
65973-37-7
7416-34-4
AB00514709
AC-7052
AC1L2N2H
AC1Q2SRY
AC1Q6J6B
BPBio1_001374
BRD-A65280694-003-03-8
BSPBio_001249
C07230
C16H24N2O2
CHEBI:103799
CHEMBL460
CID23897
D08226
DB01618
HSDB 3131
 
I14-11948
L001248
LS-83891
MOLINDONE
Moban
MolPort-005-940-887
Molindona
Molindona [INN-Spanish]
Molindona [inn-spanish]
Molindone
Molindone (INN)
Molindone (MOL)
Molindone Monohydrochloride
Molindone [INN:BAN]
Molindonum
Molindonum [INN-Latin]
Molindonum [inn-latin]
NCGC00162218-01
NCGC00162218-02
NCGC00162218-03
Oprea1_038890
Prestwick0_001035
Prestwick1_001035
Prestwick2_001035
Prestwick3_001035
SPBio_003100
UNII-RT3Y3QMF8N
2
Risperidoneapproved, investigationalPhase 4487106266-06-25073
Synonyms:
106266-06-2
3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
AB00514010
AC-1306
AC1L1JJU
BIDD:GT0262
BRD-K53857191-001-04-5
BRN 4891881
Belivon
Bio-0092
Buspirone
C23H27FN4O2
CAS-106266-06-2
CHEBI:8871
CHEMBL85
CID5073
CPD000466323
Consta, Risperdal
D00426
D018967
DB00734
EU-0101074
HMS1571M19
HMS2051H07
HMS2089C22
HSDB 7580
I01-1156
Jsp000573
KS-1106
L000510
LS-134196
Lopac-R-118
MLS000759429
MLS001165758
MLS001424081
MolPort-002-885-858
 
NCGC00015883-01
NCGC00015883-02
NCGC00015883-03
NCGC00094352-01
NCGC00094352-02
NCGC00094352-03
NCGC00179257-01
Prestwick0_001029
Prestwick1_001029
R 62 766
R 64 766, Risperdal, Risperidone
R 64,766
R 64766
R-118
R-64,766
R-64-766
R-64766
R64,766
R64766
Rispen
Risperdal
Risperdal (TN)
Risperdal Consta
Risperdal M-Tab
Risperidal
Risperidal M-Tab
Risperidona
Risperidona [Spanish]
Risperidone
Risperidone (JAN/USAN/INN)
Risperidone (RIS)
Risperidone [USAN:BAN:INN]
Risperidone, placebo
Risperidonum
Risperidonum [Latin]
Risperin
Rispolept
Rispolin
S1615_Selleck
SAM001246595
SMR000466323
SPBio_003078
STK646402
Sequinan
Spiron
TL8000230
UNII-L6UH7ZF8HC
risperdone
risperidone
3
Olanzapineapproved, investigationalPhase 4395132539-06-14585
Synonyms:
132539-06-1
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10 H -thieno[2,3- b ] [1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
AC-665
AC1L1IHS
AKOS000282888
ALKS-7921
BIDD:GT0332
BIDD:PXR0138
Bio-0169
C07322
C076029
C17H20N4S
CHEBI:7735
CHEMBL715
CID4585
CPD000466345
D00454
DB00334
Eli Lilly brand of olanzapine
HMS2051H05
HMS2089M04
HMS2093I04
I06-0784
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
Jsp001969
KS-1090
L000455
L005958
LS-152313
LY 170053
LY-170052
 
LY-170053
Lanzac
Lilly brand of olanzapine
MLS000759457
MLS001165781
MLS001195646
MLS001424057
Midax
MolPort-002-885-845
MolPort-003-666-569
MolPort-005-977-341
NCGC00096077-01
NCGC00096077-03
NCGC00096077-04
Olansek
Olanzapin
Olanzapina
Olanzapine
Olanzapine (JAN/USAN/INN)
Olanzapine (OLA)
Olanzapine [USAN:INN]
Olanzapinum
S2493_Selleck
SAM001246652
SMR000466345
SPECTRUM1505024
STK634338
Symbyax
TL8000772
UNII-N7U69T4SZR
Zalasta
Zydis
Zyprexa
Zyprexa (TN)
Zyprexa Intramuscular
Zyprexa Velotab
Zyprexa Zydis
olanzapina
olanzapine
olanzapinum
4
DopamineapprovedPhase 4, Phase 2375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
5AntiemeticsPhase 43888
6Peripheral Nervous System AgentsPhase 422776
7Serotonin AgentsPhase 4, Phase 23102
8Tranquilizing AgentsPhase 4, Phase 24164
9Serotonin Uptake InhibitorsPhase 41570
10Serotonin AntagonistsPhase 4, Phase 21381
11
SerotoninPhase 4, Phase 2356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
12Psychotropic DrugsPhase 4, Phase 26279
13Central Nervous System DepressantsPhase 4, Phase 212806
14Autonomic AgentsPhase 49774
15Neurotransmitter Uptake InhibitorsPhase 43464
16Dopamine AgentsPhase 4, Phase 23759
17Antipsychotic AgentsPhase 4, Phase 22359
18Dopamine AntagonistsPhase 4, Phase 21083
19Neurotransmitter AgentsPhase 4, Phase 217734
20Gastrointestinal AgentsPhase 48109
21Rho(D) Immune GlobulinPhase 3317
22Immunoglobulins, IntravenousPhase 3324
23gamma-GlobulinsPhase 3317
24ImmunoglobulinsPhase 36045
25AntibodiesPhase 36045
26
ZiprasidoneapprovedPhase 2145146939-27-760854
Synonyms:
138982-67-9 (hydrochloride monohydrate)
146939-27-7
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
6-chloro-5-[2-[4-(7-thia-8-azabicyclo[4.3.0]nona-1,3,5,8-tetraen-9-yl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one
AC1L1U27
Ambap122883-93-6
BIDD:GT0042
C07568
C21H21ClN4OS
CHEBI:10119
CHEMBL708
CID60854
CP 88059
CP 88059-01
CP-88,059
CP-88,059-01
CP-88,059-1
CP-88059-1
CPD000466328
D08687
DB00246
 
Geodon
Geodon Oral
I14-0766
L000659
LS-83744
MLS000759435
MolPort-003-850-885
SAM001246607
SMR000466328
TL8000889
UNII-6UKA5VEJ6X
Zeldox
Zipradon
Zipradon (TN)
Ziprasidona
Ziprasidone
Ziprasidone (INN)
Ziprasidone [INN:BAN]
Ziprasidone hydrochloride
Ziprasidone mesylate trihydrate
Ziprasidonum
ziprasidona
ziprasidonum
ziprazidone
27
Aripiprazoleapproved, investigational353129722-12-960795
Synonyms:
129722-12-9
24-29-3
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
AC-1554
AC1L1TXZ
AC1Q3T38
ALKS-9070
Abilify
Abilify (TN)
Abilify Discmelt
Abilitat
Aripiprazol
Aripiprazole
Aripiprazole (JAN/USAN/INN)
Aripiprazole [USAN]
Aripiprazolum
Aripirazole
Arpizol
Asprito|
BMS-337039
Bio-0004
Bristol-Myers Squibb brand of aripiprazole
C094645
C12564
C23H27Cl2N3O2
CHEBI:31236
CHEMBL1112
CID60795
CPD000466383
 
D01164
DB01238
Discmelt
FT-0082572
HMS2051I18
HMS2089M20
HMS2093F22
HSDB 7320
KS-1030
L001339
LS-142666
MLS000759517
MLS001165779
MLS001195621
MLS001424078
MolPort-002-885-808
MolPort-003-844-657
NCGC00159510-02
NCGC00159510-03
OPC 31
OPC-14597
OPC-31
Opc 14597
Otsuka brand of aripiprazole
Pripiprazole
S06-0010
SAM001246750
SMR000466383
STK625160
TL8000707
TL80090184
UNII-82VFR53I78
aripiprazol
aripiprazole
aripiprazolum
||OPC 14597

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS)CompletedNCT00053703Phase 4
2Efficacy Study of Early Onset of Antipsychotic Drug Action in SchizophreniaCompletedNCT00337662Phase 4
3Treatment With Risperidone Long Acting Injectable (RLAI) in an Early Phase of PsychosisCompletedNCT00369239Phase 4
45-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset SchizophreniaRecruitingNCT02435654Phase 4
5Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
6Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset PsychosisUnknown statusNCT00465920Phase 2
7Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic DisordersUnknown statusNCT02097563Phase 2
8Ziprasidone in Early Onset Schizophrenia Spectrum DisordersCompletedNCT01006551Phase 2
9Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS)CompletedNCT02764164
10Cognitive Remediation Therapy (CRT) in Adolescents With EOSCompletedNCT01701609
11Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission SchizophreniaCompletedNCT01781364
12Intensive Computerized Brain Training (ICBT) in Youth With Early Onset Psychosis (EOP)CompletedNCT01027962
13Sex Differences in Early Brain Development; Brain Development in Turner SyndromeCompletedNCT00877942
14Evaluating Genetic Risk Factors for Childhood-Onset SchizophreniaRecruitingNCT00001198
15Aripiprazole Treatment of the ProdromeTerminatedNCT00169949

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

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Anatomical Context for Early-Onset Schizophrenia

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MalaCards organs/tissues related to Early-Onset Schizophrenia:

36
Brain, Cortex, Cingulate cortex, Temporal lobe, Testes, Thalamus, Prefrontal cortex

Publications for Early-Onset Schizophrenia

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Articles related to Early-Onset Schizophrenia:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
Time perception of simultaneous and sequential events in early-onset schizophrenia. (27388526)
2016
2
Altered expression of mRNA profiles in blood of early-onset schizophrenia. (26733343)
2016
3
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. (26916502)
2016
4
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. (27384868)
2016
5
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. (26801655)
2016
6
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. (27000303)
2016
7
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. (27992258)
2016
8
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. (27015717)
2016
9
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. (27737473)
2016
10
Gestational length affects neurocognition in early-onset schizophrenia. (27474856)
2016
11
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. (27804260)
2016
12
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. (26001923)
2015
13
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. (25840049)
2015
14
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. (26573387)
2015
15
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. (26230626)
2015
16
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. (25745977)
2015
17
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. (26297473)
2015
18
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. (25779033)
2015
19
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. (26440542)
2015
20
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. (25999041)
2015
21
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. (26484249)
2015
22
Atypical antipsychotics in the treatment of early-onset schizophrenia. (25897226)
2015
23
Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia. (26071585)
2015
24
Assessing and Treating Early Onset Schizophrenia at Schools. (26101010)
2015
25
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. (25967042)
2015
26
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. (25130214)
2014
27
Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial. (25062593)
2014
28
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. (25520226)
2014
29
Systematic review of the efficacy and tolerability of Clozapine in the treatment of youth with early onset schizophrenia. (24119631)
2014
30
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study. (24831926)
2014
31
Relative stability of neurocognitive deficits in early onset schizophrenia spectrum patients. (24811433)
2014
32
The When and Where of Working Memory Dysfunction in Early-Onset Schizophrenia--A Functional Magnetic Resonance Imaging Study. (24675869)
2014
33
Adolescent insanity revisited: course and outcome in early-onset schizophrenia spectrum psychoses in an 8-year follow-up study. (24794640)
2014
34
Different and Shared Brain Volume Abnormalities in Late- and Early-Onset Schizophrenia. (25358262)
2014
35
White matter abnormalities and cognitive impairment in early-onset schizophrenia-spectrum disorders. (24565363)
2014
36
Neuropsychological deficits in the prodromal phase and course of an early-onset schizophrenia. A case report. (24846865)
2014
37
Brain network informed subject community detection in early-onset schizophrenia. (24989351)
2014
38
Patterns and correlates of expressed emotion, perceived criticism, and rearing style in first admitted early-onset schizophrenia spectrum disorders. (25259947)
2014
39
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
40
Aberrant default mode functional connectivity in early onset schizophrenia. (23923052)
2013
41
Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings. (24012081)
2013
42
Changes in the diagnosed incidence of early onset schizophrenia over four decades. (22906158)
2013
43
Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report. (23714054)
2013
44
Health service registry data in psychiatric epidemiology: challenges for definition and interpretation: an editorial comment to: Okkels et al.'s 'changes in the diagnosed incidence of early onset schizophrenia over four decades' (1). (23240595)
2013
45
Metabolic changes in first-episode early-onset schizophrenia with second-generation antipsychotics. (23968390)
2013
46
Clozapine augmented with amisulpride in 3 cases of treatment-resistant early- and very early-onset schizophrenia. (23764685)
2013
47
T102C polymorphism of serotonin 2A type receptor gene confers susceptibility to (early onset) schizophrenia in Han Chinese: an association study and meta-analysis. (23857788)
2013
48
Neurocognition in early-onset schizophrenia. (24012082)
2013
49
Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach. (23364281)
2013
50
Hematological and cardiometabolic safety of clozapine in the treatment of very early onset schizophrenia: a retrospective chart review. (24111981)
2013

Variations for Early-Onset Schizophrenia

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Expression for genes affiliated with Early-Onset Schizophrenia

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Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for genes affiliated with Early-Onset Schizophrenia

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Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8COMT, MAOA
2
Show member pathways
9.8COMT, MAOA
39.7BDNF, SOX10, TH
49.4COMT, MAOA, TH
59.2DRD3, DRD4, HTR2A
6
Show member pathways
9.1BDNF, DRD1, DRD2, MAOA, TH
79.0DRD1, DRD2, DRD3, DRD4
8
Show member pathways
9.0COMT, DBH, MAOA, TH
9
Show member pathways
9.0COMT, DBH, MAOA, TH
10
Show member pathways
8.9DRD2, DRD3, DRD4, TH
118.8HTR2A, HTR3A, MAOA, SLC6A4
12
Show member pathways
8.8DRD1, DRD2, DRD3, DRD4, HTR2A
13
Show member pathways
8.8DBH, MAOA, SLC6A4, TH, TNF
14
Show member pathways
8.0BDNF, DRD1, DRD2, DRD3, DRD4, INS
15
Show member pathways
7.9BDNF, DNMT3B, DRD1, DRD2, INS, MAOA
167.5BDNF, HTR2A, HTR3A, MAOA, SLC6A4, TH
17
Show member pathways
6.6COMT, DRD1, DRD2, DRD3, DRD4, HTR2A

GO Terms for genes affiliated with Early-Onset Schizophrenia

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Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:00347749.8DBH, INS
2axonGO:00304249.2COMT, DRD2, HTR2A, HTR3A, TH
3integral component of plasma membraneGO:00058878.8DRD1, DRD2, DRD3, DRD4, HTR2A, SLC6A4
4neuronal cell bodyGO:00430258.7DRD1, DRD4, HTR2A, HTR3A, TH

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron migrationGO:002185310.8DRD1, DRD2
2positive regulation of glycolytic processGO:004582110.8HTR2A, INS
3grooming behaviorGO:000762510.7DRD1, DRD2
4negative regulation of synaptic transmission, glutamatergicGO:005196710.7DRD2, HTR2A
5negative regulation of circadian sleep/wake cycle, sleepGO:004232110.7DRD1, DRD2
6orbitofrontal cortex developmentGO:002176910.7DRD1, DRD2
7phospholipase C-activating dopamine receptor signaling pathwayGO:006015810.7DRD1, DRD2
8positive regulation of long-term synaptic potentiationGO:190027310.7DRD1, DRD2
9negative regulation of lipid catabolic processGO:005099510.7INS, TNF
10regulation of protein secretionGO:005070810.7INS, TNF
11mating behaviorGO:000761710.6DRD1, TH
12cellular response to nicotineGO:007131610.6TH, TNF
13striatum developmentGO:002175610.6DRD1, DRD2
14positive regulation of kinase activityGO:003367410.6DRD4, HTR2A
15regulation of dopamine metabolic processGO:004205310.6DRD1, DRD4
16negative regulation of voltage-gated calcium channel activityGO:190138610.5DRD2, DRD4
17positive regulation of dopamine uptake involved in synaptic transmissionGO:005158610.5DRD2, DRD4
18maternal behaviorGO:004271110.5DBH, DRD1
19neurotransmitter catabolic processGO:004213510.5COMT, MAOA
20response to salt stressGO:000965110.5TH, TNF
21positive regulation of potassium ion transportGO:004326810.5DLG1, DRD1
22catecholamine biosynthetic processGO:004242310.4DBH, TH
23norepinephrine biosynthetic processGO:004242110.4DBH, TH
24adenylate cyclase-activating dopamine receptor signaling pathwayGO:000719110.4DRD1, DRD3
25response to activityGO:001482310.4DNMT3B, DRD1, TH
26acid secretionGO:004671710.4DRD2, DRD3
27G-protein coupled receptor internalizationGO:000203110.3DRD2, DRD3
28fear responseGO:004259610.3DBH, DRD4
29negative regulation of dopamine receptor signaling pathwayGO:006016010.3DRD2, DRD3
30positive regulation of renal sodium excretionGO:003581510.3DRD2, DRD3
31regulation of cAMP metabolic processGO:003081410.3DRD2, DRD3
32regulation of locomotion involved in locomotory behaviorGO:009032510.3DRD2, DRD3
33synapse assemblyGO:000741610.3BDNF, DRD1, DRD2
34associative learningGO:000830610.3DBH, DRD1, DRD2
35response to nicotineGO:003509410.3DRD1, DRD2, TH
36short-term memoryGO:000761410.3COMT, DRD4
37response to toxic substanceGO:000963610.3DNMT3B, DRD2, SLC6A4
38temperature homeostasisGO:000165910.3DRD1, DRD2, HTR2A
39peristalsisGO:003043210.2DLG1, DRD1, DRD2
40response to steroid hormoneGO:004854510.1DRD1, DRD4, TH
41regulation of dopamine secretionGO:001405910.1DRD2, DRD3, HTR2A
42behavioral response to ethanolGO:004814910.1DBH, DRD2, DRD4
43prepulse inhibitionGO:006013410.1DRD1, DRD2, DRD3
44regulation of dopamine uptake involved in synaptic transmissionGO:005158410.1DRD1, DRD2, DRD3
45dopamine catabolic processGO:004242010.1COMT, DBH, MAOA
46response to estradiolGO:003235510.0DNMT3B, DRD1, SLC6A4, TH
47response to morphineGO:004327810.0DRD1, DRD2, DRD3
48response to hypoxiaGO:000166610.0DNMT3B, DRD2, SLC6A4, TH
49cellular calcium ion homeostasisGO:000687410.0DRD3, DRD4, HTR2A
50adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:000719510.0DRD2, DRD3, DRD4

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.0INS, YWHAH
2dopamine neurotransmitter receptor activity, coupled via GsGO:00015889.7DRD1, DRD3, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.7DRD2, DRD3, DRD4
4dopamine neurotransmitter receptor activityGO:00049529.5DRD1, DRD2, DRD3, DRD4
5dopamine bindingGO:00352409.2DRD1, DRD2, DRD3, DRD4, TH
6drug bindingGO:00081449.1DRD1, DRD2, DRD3, DRD4, HTR2A
7serotonin bindingGO:00513789.1HTR2A, HTR3A, MAOA

Sources for Early-Onset Schizophrenia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet