MCID: ERL020
MIFTS: 51

Early-Onset Schizophrenia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Early-Onset Schizophrenia

MalaCards integrated aliases for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 55
Early Onset Schizophrenia 69

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA96369
ICD10 via Orphanet 33 F20.8
UMLS 69 C1656427

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to tic disorder and schizoaffective disorder. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Circadian entrainment. The drugs Dopamine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cingulate cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 tic disorder 29.8 DRD2 DRD4 HTR2A
2 schizoaffective disorder 28.9 BDNF COMT DRD2 DRD3 HTR2A SLC6A4
3 anxiety 28.5 BDNF COMT HTR2A HTR3A MAOA SLC6A4
4 autism spectrum disorder 28.2 BDNF COMT DRD2 DRD3 DRD4 HTR2A
5 gilles de la tourette syndrome 28.2 BDNF COMT DBH DRD2 DRD4 HTR3A
6 autism 27.9 BDNF COMT DRD2 DRD3 DRD4 HTR2A
7 psychotic disorder 27.1 BDNF COMT DRD1 DRD2 DRD3 DRD4
8 schizophrenia 27.0 BDNF COMT DBH DLG1 DRD1 DRD2
9 obsessive-compulsive disorder 27.0 BDNF COMT DRD1 DRD2 DRD3 DRD4
10 attention deficit-hyperactivity disorder 26.9 BDNF COMT DBH DRD1 DRD2 DRD3
11 bipolar disorder 26.2 BDNF COMT DBH DRD1 DRD2 DRD3
12 childhood-onset schizophrenia 11.5
13 alcohol use disorder 10.4 DRD2 SLC6A4
14 drug-induced mental disorder 10.4 DRD2 HTR2A NDUFS4
15 drug psychosis 10.4 DRD2 HTR2A NDUFS4
16 neonatal hypoxic and ischemic brain injury 10.3 BDNF TH
17 alcoholic psychosis 10.3 DRD2 HTR2A SLC6A4
18 periodic limb movement disorder 10.3 DRD2 HTR2A SLC6A4
19 bruxism 10.3 DRD2 HTR2A SLC6A4
20 supranuclear palsy, progressive, 1 10.3 DRD2 NDUFS4 TH
21 apnea, obstructive sleep 10.3 HTR2A INS TNF
22 traumatic brain injury 10.3 BDNF COMT DRD2
23 dysthymic disorder 10.3 HTR2A MAOA SLC6A4
24 brain injury 10.2 BDNF COMT DRD2
25 alexithymia 10.2 COMT DRD2 SLC6A4
26 megacolon 10.2 DRD2 HTR2A SOX10
27 schizophrenia 5 10.2 HTR2A LOC110806262
28 sleep apnea 10.2 HTR2A INS TNF
29 hereditary dystonia 10.2 DBH TH
30 atypical depressive disorder 10.2 MAOA SLC6A4
31 phobic disorder 10.2 COMT MAOA SLC6A4
32 heroin dependence 10.2 BDNF DRD2 DRD4
33 phobia, specific 10.2 COMT MAOA
34 nervous system disease 10.1 BDNF INS TH TNF
35 dystonia 1, torsion, autosomal dominant 10.1 COMT MAOA TH
36 dystonia 11, myoclonic 10.1 DBH DRD2 TH
37 alzheimer disease 5 10.1 HTR2A LOC110806262 SLC6A4
38 multiple system atrophy 1 10.1 DBH DRD2 TH
39 eating disorder 10.1 BDNF COMT DRD2 SLC6A4
40 postural hypotension 10.1 DBH INS
41 migraine with aura 10.1 DBH DRD2 SLC6A4
42 bulimia nervosa 2 10.1 BDNF COMT HTR2A SLC6A4
43 pure autonomic failure 10.1 DBH MAOA TH
44 schizophreniform disorder 10.1 COMT DRD2
45 postpartum depression 10.1 BDNF COMT MAOA SLC6A4
46 obsessive-compulsive personality disorder 10.0 DRD3 SLC6A4
47 antisocial personality disorder 10.0 COMT DRD2 MAOA SLC6A4
48 tobacco addiction 10.0 COMT DRD2 HTR2A MAOA
49 polysubstance abuse 10.0 COMT DRD2 DRD3
50 pervasive developmental disorder 10.0 BDNF LOC110806262 SLC6A4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 BDNF COMT DBH DLG1 DRD1 DRD2
2 homeostasis/metabolism MP:0005376 10.36 DBH DLG1 DRD1 DRD2 DRD3 DRD4
3 growth/size/body region MP:0005378 10.32 BDNF DBH DLG1 DNMT3B DRD1 DRD2
4 endocrine/exocrine gland MP:0005379 10.31 BDNF COMT DBH DLG1 DNMT3B DRD2
5 cardiovascular system MP:0005385 10.3 DRD1 DRD2 DRD3 INS MAOA NDUFS4
6 mortality/aging MP:0010768 10.25 BDNF DBH DLG1 DNMT3B DRD1 DRD2
7 nervous system MP:0003631 10.25 DLG1 DNMT3B DRD1 DRD2 DRD3 DRD4
8 integument MP:0010771 10.17 BDNF DBH DRD1 DRD2 HTR3A INS
9 digestive/alimentary MP:0005381 10.16 BDNF DLG1 DRD1 DRD2 DRD3 HTR2A
10 muscle MP:0005369 10.02 INS NDUFS4 SLC6A4 TNF DLG1 DRD1
11 normal MP:0002873 9.81 BDNF DBH DRD1 DRD2 INS NDUFS4
12 no phenotypic analysis MP:0003012 9.8 DNMT3B DRD2 INS TH TNF BDNF
13 respiratory system MP:0005388 9.61 BDNF COMT DLG1 DRD1 DRD2 NDUFS4
14 vision/eye MP:0005391 9.32 DRD4 INS NDUFS4 TH TNF BDNF

Drugs & Therapeutics for Early-Onset Schizophrenia

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Molindone Approved Phase 4 7416-34-4 23897
5
Serotonin Phase 4,Phase 2 50-67-9 5202
6 Central Nervous System Depressants Phase 4,Phase 2
7 Serotonin Agents Phase 4,Phase 2
8 Serotonin Antagonists Phase 4,Phase 2
9 Serotonin Uptake Inhibitors Phase 4
10 Gastrointestinal Agents Phase 4
11 Neurotransmitter Agents Phase 4,Phase 2
12 Tranquilizing Agents Phase 4,Phase 2
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Dopamine Agents Phase 4,Phase 2
15 Dopamine Antagonists Phase 4,Phase 2
16 Peripheral Nervous System Agents Phase 4
17 Antiemetics Phase 4
18 Psychotropic Drugs Phase 4,Phase 2
19 Antipsychotic Agents Phase 4,Phase 2
20 Autonomic Agents Phase 4
21
Ziprasidone Approved Phase 2 146939-27-7 60854
22
Heparin Approved, Investigational 9005-49-6 46507594 772
23
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
24
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
25
Epinephrine Approved, Vet_approved 51-43-4 5816
26
Midazolam Approved, Illicit 59467-70-8 4192
27
Nicardipine Approved, Investigational 55985-32-5 4474
28
Ciprofloxacin Approved, Investigational 85721-33-1 2764
29
Morphine Approved, Investigational 57-27-2 5288826
30
Cidofovir Approved 113852-37-2 60613
31
Valproic Acid Approved, Investigational 99-66-1 3121
32
Warfarin Approved 81-81-2 54678486 6691
33
Haloperidol Approved 52-86-8 3559
34
Topiramate Approved 97240-79-4 5284627
35
Clozapine Approved 5786-21-0 2818
36
Timolol Approved 26839-75-8 5478 33624
37
Prednisolone Approved, Vet_approved 50-24-8 5755
38
Fosphenytoin Approved, Investigational 93390-81-9 56339
39
Tobramycin Approved, Investigational 32986-56-4 36294 5496
40
Oseltamivir Approved 196618-13-0, 204255-11-8 65028
41
Pentobarbital Approved, Investigational, Vet_approved 76-74-4 4737
42
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
43
Alfentanil Approved, Illicit 71195-58-9 51263
44
Aripiprazole Approved, Investigational 129722-12-9 60795
45
Hydromorphone Approved, Illicit 466-99-9 5284570
46
Meropenem Approved, Investigational 119478-56-7 441130 64778
47
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
48
Methylprednisolone Approved, Vet_approved 83-43-2 6741
49 Racepinephrine Approved 329-65-7
50 Etiracetam Investigational 33996-58-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS) Completed NCT00053703 Phase 4 Risperidone;Olanzapine (enrollment closed in this treatment);Molindone
2 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia Recruiting NCT02435654 Phase 4 olanzapine
3 Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Completed NCT01006551 Phase 2 Ziprasidone
4 Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS) Completed NCT02764164
5 Cognitive Remediation Therapy (CRT) in Adolescents With EOS Completed NCT01701609
6 Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia Completed NCT01781364
7 Reward Processing in Schizophrenia Recruiting NCT03068793
8 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Recruiting NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

38
Brain, Cortex, Cingulate Cortex, Temporal Lobe, Testes, Thalamus, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 216)
# Title Authors Year
1
Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. ( 29299680 )
2018
2
The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population. ( 29100974 )
2018
3
Evaluation of white matter structure changes, as assessed in tractography, and cognitive dysfunctions in patients with early onset schizophrenia and their first-degree relatives. ( 28987061 )
2017
4
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
5
Early-onset schizophrenia: Symptoms and social class of origin. ( 28701088 )
2017
6
Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates. ( 28976410 )
2017
7
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28657177 )
2017
8
Pronounced inhibition-related hypofrontal dysfunction in early-onset schizophrenia as indexed by NoGo-P300 amplitude. ( 28174035 )
2017
9
Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. ( 28793242 )
2017
10
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. ( 28835863 )
2017
11
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
12
Treatment retention of risperidone long-acting injection in patients with early-onset schizophrenia in Japan. ( 28558887 )
2017
13
Clozapine-Related Tachycardia in an Adolescent with Treatment-Resistant Early Onset Schizophrenia. ( 28323458 )
2017
14
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28370311 )
2017
15
Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia. ( 28370310 )
2017
16
Predictors of treatment response and drop out in the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. ( 28595147 )
2017
17
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
18
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. ( 27000303 )
2016
19
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
20
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
21
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
22
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
23
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
24
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
25
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2016
26
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
27
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
28
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. ( 25840049 )
2015
29
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. ( 26230626 )
2015
30
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2015
31
Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia. ( 26071585 )
2015
32
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. ( 25967042 )
2015
33
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
34
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. ( 25999041 )
2015
35
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
36
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. ( 26001923 )
2015
37
Assessing and Treating Early Onset Schizophrenia at Schools. ( 26101010 )
2015
38
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. ( 26484249 )
2015
39
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. ( 26440542 )
2015
40
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
41
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. ( 26297473 )
2015
42
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. ( 25520226 )
2014
43
Relative stability of neurocognitive deficits in early onset schizophrenia spectrum patients. ( 24811433 )
2014
44
Patterns and correlates of expressed emotion, perceived criticism, and rearing style in first admitted early-onset schizophrenia spectrum disorders. ( 25259947 )
2014
45
Brain network informed subject community detection in early-onset schizophrenia. ( 24989351 )
2014
46
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study. ( 24831926 )
2014
47
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. ( 25130214 )
2014
48
The When and Where of Working Memory Dysfunction in Early-Onset Schizophrenia--A Functional Magnetic Resonance Imaging Study. ( 24675869 )
2014
49
Adolescent insanity revisited: course and outcome in early-onset schizophrenia spectrum psychoses in an 8-year follow-up study. ( 24794640 )
2014
50
Neuropsychological deficits in the prodromal phase and course of an early-onset schizophrenia. A case report. ( 24846865 )
2014

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 BDNF DRD1 DRD2 DRD3 DRD4 INS
2
Show member pathways
12.65 COMT DRD1 DRD2 DRD3 DRD4 MAOA
3 12.21 DRD1 DRD2 DRD3 DRD4
5 11.9 HTR2A HTR3A MAOA SLC6A4
6
Show member pathways
11.87 BDNF DRD1 DRD2 MAOA TH
7
Show member pathways
11.85 DRD2 DRD3 DRD4 TH
8
Show member pathways
11.83 DRD1 DRD2 DRD3 DRD4 HTR2A
9 11.78 DRD3 DRD4 HTR2A
10 11.72 DBH MAOA TH
11 11.7 DRD1 DRD2 HTR2A
12
Show member pathways
11.68 COMT DBH MAOA TH
13 11.64 BDNF SOX10 TH
14 11.44 BDNF HTR2A HTR3A MAOA SLC6A4 TH
15
Show member pathways
11.12 COMT MAOA SLC6A4
16 11.03 DRD1 DRD2 DRD3
17 11 HTR2A HTR3A MAOA SLC6A4
18
Show member pathways
10.99 DBH MAOA SLC6A4 TH TNF
19 10.8 COMT MAOA TH
20
Show member pathways
10.8 COMT DBH MAOA TH
21
Show member pathways
10.77 COMT MAOA

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.02 COMT DRD2 HTR2A HTR3A TH

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.96 DNMT3B DRD2 SLC6A4 TH
2 response to ethanol GO:0045471 9.93 DRD2 DRD3 HTR3A TH
3 response to toxic substance GO:0009636 9.91 DNMT3B DRD2 SLC6A4
4 locomotory behavior GO:0007626 9.91 DBH DRD1 DRD2 DRD3 TH
5 response to estradiol GO:0032355 9.9 DNMT3B SLC6A4 TH
6 cellular calcium ion homeostasis GO:0006874 9.9 DRD3 DRD4 HTR2A
7 learning GO:0007612 9.88 COMT DRD1 DRD3 TH
8 memory GO:0007613 9.88 DBH DRD1 HTR2A SLC6A4 TH
9 synapse assembly GO:0007416 9.86 BDNF DRD1 DRD2
10 social behavior GO:0035176 9.86 DRD3 DRD4 SLC6A4 TH
11 response to drug GO:0042493 9.86 COMT DNMT3B DRD1 DRD2 DRD3 HTR2A
12 regulation of protein phosphorylation GO:0001932 9.85 DRD1 NDUFS4 TNF
13 negative regulation of protein kinase B signaling GO:0051898 9.85 DLG1 DRD2 DRD3
14 visual learning GO:0008542 9.84 DBH DRD1 DRD2 DRD3
15 negative regulation of adenylate cyclase activity GO:0007194 9.83 DRD2 DRD3 DRD4
16 associative learning GO:0008306 9.8 DBH DRD1 DRD2
17 arachidonic acid secretion GO:0050482 9.79 DRD2 DRD3 DRD4
18 regulation of dopamine secretion GO:0014059 9.79 DRD2 DRD3 HTR2A
19 temperature homeostasis GO:0001659 9.78 DRD1 DRD2 HTR2A
20 behavioral response to ethanol GO:0048149 9.77 DBH DRD2 DRD4
21 dopamine receptor signaling pathway GO:0007212 9.76 DRD1 DRD2 DRD3 DRD4
22 prepulse inhibition GO:0060134 9.75 DRD1 DRD2 DRD3
23 negative regulation of lipid catabolic process GO:0050995 9.74 INS TNF
24 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.74 DRD2 DRD3 DRD4
25 regulation of protein secretion GO:0050708 9.73 INS TNF
26 positive regulation of long-term synaptic potentiation GO:1900273 9.73 DRD2 INS
27 positive regulation of kinase activity GO:0033674 9.73 DRD4 HTR2A
28 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.73 DRD2 HTR2A
29 neurotransmitter biosynthetic process GO:0042136 9.72 SLC6A4 TH
30 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.72 DRD1 DRD2
31 negative regulation of voltage-gated calcium channel activity GO:1901386 9.72 DRD2 DRD4
32 positive regulation of renal sodium excretion GO:0035815 9.72 DRD2 DRD3
33 peristalsis GO:0030432 9.72 DLG1 DRD1 DRD2
34 response to cocaine GO:0042220 9.72 DNMT3B DRD1 DRD2 DRD3 HTR3A
35 maternal behavior GO:0042711 9.71 DBH DRD1
36 striatum development GO:0021756 9.71 DRD1 DRD2
37 grooming behavior GO:0007625 9.71 DRD1 DRD2
38 G-protein coupled receptor internalization GO:0002031 9.71 DRD2 DRD3
39 synaptic transmission, dopaminergic GO:0001963 9.71 DRD1 DRD2 DRD3 TH
40 neurotransmitter catabolic process GO:0042135 9.7 COMT MAOA
41 positive regulation of potassium ion transport GO:0043268 9.7 DLG1 DRD1
42 catecholamine metabolic process GO:0006584 9.7 COMT MAOA
43 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.7 DRD1 DRD3
44 dopamine catabolic process GO:0042420 9.7 COMT DBH MAOA
45 regulation of dopamine metabolic process GO:0042053 9.69 DRD1 DRD4
46 response to salt stress GO:0009651 9.69 TH TNF
47 cellular response to nicotine GO:0071316 9.68 TH TNF
48 mating behavior GO:0007617 9.68 DRD1 TH
49 regulation of cAMP metabolic process GO:0030814 9.68 DRD2 DRD3
50 catecholamine biosynthetic process GO:0042423 9.67 DBH TH

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.77 DRD1 DRD2 DRD3 DRD4 HTR2A
2 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 HTR2A
3 monooxygenase activity GO:0004497 9.5 DBH TH YWHAH
4 insulin-like growth factor receptor binding GO:0005159 9.43 INS YWHAH
5 serotonin binding GO:0051378 9.4 HTR2A HTR3A
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
7 dopamine neurotransmitter receptor activity GO:0004952 9.26 DRD1 DRD2 DRD3 DRD4
8 dopamine binding GO:0035240 9.02 DRD1 DRD2 DRD3 DRD4 TH

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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