MCID: ERL020
MIFTS: 46

Early-Onset Schizophrenia

Categories: Neuronal diseases, Rare diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

MalaCards integrated aliases for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 56
Early Onset Schizophrenia 69

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA96369
ICD10 via Orphanet 34 F20.8

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and allergic hypersensitivity disease. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Circadian entrainment. The drugs Dopamine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cingulate cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 9 Schizophrenia 17
Schizophrenia 16 Schizophrenia 10
Schizophrenia 19 Schizophrenia 4
Schizophrenia 15 Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 schizophrenia 26.1 BDNF COMT DBH DRD1 DRD2 DRD3
2 allergic hypersensitivity disease 10.6 DRD2 HTR2A NDUFS4
3 vascular cancer 10.5 DRD2 HTR2A NDUFS4
4 splenic abscess 10.5 DRD2 HTR2A SLC6A4
5 hyperthyroxinemia 10.5 DRD2 HTR2A SLC6A4
6 endotheliitis 10.5 BDNF TH
7 pompholyx 10.5 DRD2 HTR2A SLC6A4
8 neurogenic bladder 10.4 HTR2A MAOA SLC6A4
9 brain meningioma 10.4 BDNF COMT DRD2
10 anosognosia 10.4 COMT DRD2 SLC6A4
11 diabetic encephalopathy 10.4 HTR2A INS TNF
12 intracranial cavernous angioma 10.4 DRD2 SLC6A4
13 periampullary adenoma 10.4 HTR2A INS TNF
14 spinal meningioma 10.3 DRD2 HTR2A SOX10
15 hereditary paraganglioma-pheochromocytoma syndromes 10.3 DBH TH
16 eosinophilia-myalgia syndrome 10.3 BDNF DRD2 DRD4
17 uterus intravascular leiomyomatosis 10.3 COMT MAOA SLC6A4
18 amyloidosis, finnish type 10.3 COMT MAOA TH
19 conjunctival pigmentation 10.3 MAOA SLC6A4
20 prostate carcinoma in situ 10.3 BDNF INS TH TNF
21 long qt syndrome-11 10.2 DBH DRD2 TH
22 contact dermatitis 10.2 DRD2 DRD4 HTR2A
23 ring chromosome 14 syndrome 10.2 COMT MAOA
24 ulcerative colitis 10.2 BDNF COMT DRD2 TNF
25 pelvic inflammatory disease 10.2 DBH DRD2 SLC6A4
26 perinatal necrotizing enterocolitis 10.2 BDNF COMT DRD2 SLC6A4
27 hepatic angiomyolipoma 10.2 BDNF HTR2A SLC6A4 TH
28 pyogenic arthritis, pyoderma gangrenosum and acne 10.2 DBH MAOA TH
29 chromosome 11p13 deletion syndrome, distal 10.1 BDNF COMT HTR2A SLC6A4
30 parietal foramina 3 10.1 DBH DRD2 TH
31 chronic dacryoadenitis 10.1 BDNF COMT MAOA SLC6A4
32 tongue disease 10.1 COMT DRD2 MAOA SLC6A4
33 parkinsonism-dystonia, infantile 10.1 COMT DRD2 HTR2A MAOA
34 dissociative disorder 10.1 DRD3 SLC6A4
35 laryngeal adductor paralysis 10.1 DRD4 HTR2A SLC6A4
36 repetitive stress injuries 10.1 DBH INS
37 hypoglycemic coma 10.1 BDNF HTR2A INS MAOA SLC6A4
38 hemopericardium 10.1 DBH DRD4 INS
39 atypical autism 10.1 BDNF LOC110806262 SLC6A4
40 vallecula cancer 10.0 COMT MAOA SLC6A4 TNF
41 bipolar disorder 10.0
42 ganglioneuroma 10.0 DRD2 DRD3 TH
43 primary angle-closure glaucoma 10.0 BDNF COMT DRD1 HTR2A SLC6A4
44 rhinoscleroma 10.0 COMT DRD2
45 hallucinogen dependence 10.0 BDNF DRD2 DRD3 SLC6A4
46 c8 deficiency, type ii 10.0 COMT DRD1 DRD2 DRD4
47 cerebritis 9.9
48 neuronitis 9.9
49 antisocial personality disorder 9.9 DRD2 DRD3 DRD4
50 suppurative periapical periodontitis 9.9 DRD2 DRD3 SLC6A4 TH

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 SOX10 TH SLC6A4 TNF COMT DRD1
2 homeostasis/metabolism MP:0005376 10.36 SOX10 NDUFS4 TH SLC6A4 TNF DLG1
3 growth/size/body region MP:0005378 10.32 TNF SOX10 NDUFS4 TH SLC6A4 DLG1
4 endocrine/exocrine gland MP:0005379 10.31 SOX10 TH SLC6A4 TNF BDNF DNMT3B
5 cardiovascular system MP:0005385 10.3 TNF NDUFS4 TH SLC6A4 DNMT3B COMT
6 mortality/aging MP:0010768 10.25 TNF SOX10 NDUFS4 TH SLC6A4 DLG1
7 nervous system MP:0003631 10.25 SOX10 NDUFS4 TH SLC6A4 TNF DNMT3B
8 integument MP:0010771 10.17 SOX10 NDUFS4 TH SLC6A4 TNF BDNF
9 digestive/alimentary MP:0005381 10.16 TNF SOX10 DLG1 BDNF DRD1 DRD2
10 muscle MP:0005369 10.02 TNF NDUFS4 SLC6A4 DLG1 DRD1 HTR3A
11 normal MP:0002873 9.81 SLC6A4 SOX10 NDUFS4 TH BDNF DBH
12 no phenotypic analysis MP:0003012 9.8 TNF TH DLG1 BDNF DNMT3B DRD2
13 respiratory system MP:0005388 9.61 TNF SOX10 NDUFS4 TH DLG1 BDNF
14 vision/eye MP:0005391 9.32 TNF NDUFS4 TH DLG1 BDNF DNMT3B

Drugs & Therapeutics for Early-Onset Schizophrenia

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Molindone Approved Phase 4 7416-34-4 23897
5
Serotonin Phase 4,Phase 2 50-67-9 5202
6 Central Nervous System Depressants Phase 4,Phase 2
7 Serotonin Agents Phase 4,Phase 2
8 Serotonin Antagonists Phase 4,Phase 2
9 Serotonin Uptake Inhibitors Phase 4
10 Gastrointestinal Agents Phase 4
11 Neurotransmitter Agents Phase 4,Phase 2
12 Neurotransmitter Uptake Inhibitors Phase 4
13 Tranquilizing Agents Phase 4,Phase 2
14 Dopamine Agents Phase 4,Phase 2
15 Dopamine Antagonists Phase 4,Phase 2
16 Peripheral Nervous System Agents Phase 4
17 Antiemetics Phase 4
18 Psychotropic Drugs Phase 4,Phase 2
19 Antipsychotic Agents Phase 4,Phase 2
20 Autonomic Agents Phase 4
21 Rho(D) Immune Globulin Phase 3
22 gamma-Globulins Phase 3
23 Immunoglobulins Phase 3
24 Immunoglobulins, Intravenous Phase 3
25 Antibodies Phase 3
26
Ziprasidone Approved Phase 2 146939-27-7 60854
27
Heparin Approved, Investigational 9005-49-6 772 46507594
28
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
29
Diazepam Approved, Illicit, Vet_approved 439-14-5 3016
30
Epinephrine Approved, Vet_approved 51-43-4 5816
31
Midazolam Approved, Illicit 59467-70-8 4192
32
Nicardipine Approved 55985-32-5 4474
33
Ciprofloxacin Approved, Investigational 85721-33-1 2764
34
Morphine Approved, Investigational 57-27-2 5288826
35
Cidofovir Approved 113852-37-2 60613
36
Valproic Acid Approved, Investigational 99-66-1 3121
37
Warfarin Approved 81-81-2 6691 54678486
38
Haloperidol Approved 52-86-8 3559
39
Topiramate Approved 97240-79-4 5284627
40
Clozapine Approved 5786-21-0 2818
41
Timolol Approved 26839-75-8 33624 5478
42
Prednisolone Approved, Vet_approved 50-24-8 5755
43
Fosphenytoin Approved 93390-81-9 56339
44
Tobramycin Approved, Investigational 32986-56-4 5496 36294
45
Oseltamivir Approved 204255-11-8, 196618-13-0 65028
46
Pentobarbital Approved, Vet_approved 76-74-4 4737
47
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
48
Alfentanil Approved, Illicit 71195-58-9 51263
49
Aripiprazole Approved, Investigational 129722-12-9 60795
50
Hydromorphone Approved, Illicit 466-99-9 5284570

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS) Completed NCT00053703 Phase 4 Risperidone;Olanzapine (enrollment closed in this treatment);Molindone
2 Efficacy Study of Early Onset of Antipsychotic Drug Action in Schizophrenia Completed NCT00337662 Phase 4 olanzapine;risperidone;risperidone
3 Treatment With Risperidone Long Acting Injectable (RLAI) in an Early Phase of Psychosis Completed NCT00369239 Phase 4 risperidone long acting injectable
4 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia Recruiting NCT02435654 Phase 4 olanzapine
5 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3 Intravenous immunoglobulin
6 Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis Unknown status NCT00465920 Phase 2
7 Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Completed NCT01006551 Phase 2 Ziprasidone
8 Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS) Completed NCT02764164
9 Cognitive Remediation Therapy (CRT) in Adolescents With EOS Completed NCT01701609
10 Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia Completed NCT01781364
11 Reward Processing in Schizophrenia Recruiting NCT03068793
12 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Recruiting NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
13 Cognitive Behavioral Social Skills Training in Early Onset Psychosis Recruiting NCT03261557
14 Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia Terminated NCT00001198
15 Aripiprazole Treatment of the Prodrome Terminated NCT00169949 aripiprazole

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

39
Brain, Cortex, Cingulate Cortex, Temporal Lobe, Testes, Thalamus, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 212)
id Title Authors Year
1
Early-onset schizophrenia: Symptoms and social class of origin. ( 28701088 )
2017
2
Pronounced inhibition-related hypofrontal dysfunction in early-onset schizophrenia as indexed by NoGo-P300 amplitude. ( 28174035 )
2017
3
Treatment retention of risperidone long-acting injection in patients with early-onset schizophrenia in Japan. ( 28558887 )
2017
4
Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. ( 28793242 )
2017
5
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
6
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
7
Clozapine-Related Tachycardia in an Adolescent with Treatment-Resistant Early Onset Schizophrenia. ( 28323458 )
2017
8
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28370311 )
2017
9
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. ( 28835863 )
2017
10
Predictors of treatment response and drop out in the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. ( 28595147 )
2017
11
Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia. ( 28370310 )
2017
12
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28657177 )
2017
13
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. ( 27000303 )
2016
14
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
15
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
16
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
17
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
18
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2016
19
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
20
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
21
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
22
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
23
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
24
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. ( 26484249 )
2015
25
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. ( 25999041 )
2015
26
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. ( 26440542 )
2015
27
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
28
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
29
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
30
Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia. ( 26071585 )
2015
31
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. ( 26230626 )
2015
32
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2015
33
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. ( 25967042 )
2015
34
Assessing and Treating Early Onset Schizophrenia at Schools. ( 26101010 )
2015
35
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. ( 25840049 )
2015
36
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. ( 26001923 )
2015
37
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. ( 26297473 )
2015
38
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. ( 25130214 )
2014
39
Brain network informed subject community detection in early-onset schizophrenia. ( 24989351 )
2014
40
Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial. ( 25062593 )
2014
41
The When and Where of Working Memory Dysfunction in Early-Onset Schizophrenia--A Functional Magnetic Resonance Imaging Study. ( 24675869 )
2014
42
Adolescent insanity revisited: course and outcome in early-onset schizophrenia spectrum psychoses in an 8-year follow-up study. ( 24794640 )
2014
43
Patterns and correlates of expressed emotion, perceived criticism, and rearing style in first admitted early-onset schizophrenia spectrum disorders. ( 25259947 )
2014
44
White matter abnormalities and cognitive impairment in early-onset schizophrenia-spectrum disorders. ( 24565363 )
2014
45
Relative stability of neurocognitive deficits in early onset schizophrenia spectrum patients. ( 24811433 )
2014
46
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study. ( 24831926 )
2014
47
Systematic review of the efficacy and tolerability of Clozapine in the treatment of youth with early onset schizophrenia. ( 24119631 )
2014
48
Neuropsychological deficits in the prodromal phase and course of an early-onset schizophrenia. A case report. ( 24846865 )
2014
49
Different and Shared Brain Volume Abnormalities in Late- and Early-Onset Schizophrenia. ( 25358262 )
2014
50
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. ( 25520226 )
2014

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 BDNF DRD1 DRD2 DRD3 DRD4 INS
2
Show member pathways
12.64 COMT DRD1 DRD2 DRD3 DRD4 MAOA
3 12.21 DRD1 DRD2 DRD3 DRD4
5 11.9 HTR2A HTR3A MAOA SLC6A4
6
Show member pathways
11.87 BDNF DRD1 DRD2 MAOA TH
7
Show member pathways
11.83 DRD2 DRD3 DRD4 TH
8
Show member pathways
11.83 DRD1 DRD2 DRD3 DRD4 HTR2A
9 11.78 DRD3 DRD4 HTR2A
10 11.71 DBH MAOA TH
11
Show member pathways
11.67 COMT DBH MAOA TH
12 11.65 BDNF SOX10 TH
13 11.44 BDNF HTR2A HTR3A MAOA SLC6A4 TH
14
Show member pathways
11.14 COMT MAOA SLC6A4
15 11.08 DRD1 DRD2 DRD3
16 11 HTR2A HTR3A MAOA SLC6A4
17
Show member pathways
10.99 DBH MAOA SLC6A4 TH TNF
18 10.8 COMT MAOA TH
19
Show member pathways
10.8 COMT DBH MAOA TH
20
Show member pathways
10.73 COMT MAOA

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.02 COMT DRD2 HTR2A HTR3A TH

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.98 DNMT3B DRD2 SLC6A4 TH
2 response to ethanol GO:0045471 9.93 DRD2 DRD3 HTR3A TH
3 response to toxic substance GO:0009636 9.91 DNMT3B DRD2 SLC6A4
4 locomotory behavior GO:0007626 9.91 DBH DRD1 DRD2 DRD3 TH
5 response to estradiol GO:0032355 9.9 DNMT3B SLC6A4 TH
6 cellular calcium ion homeostasis GO:0006874 9.9 DRD3 DRD4 HTR2A
7 learning GO:0007612 9.88 COMT DRD1 DRD3 TH
8 synapse assembly GO:0007416 9.86 BDNF DRD1 DRD2
9 social behavior GO:0035176 9.86 DRD3 DRD4 SLC6A4 TH
10 response to drug GO:0042493 9.86 COMT DNMT3B DRD1 DRD2 DRD3 HTR2A
11 memory GO:0007613 9.85 DBH DRD1 HTR2A SLC6A4 TH
12 negative regulation of protein kinase B signaling GO:0051898 9.84 DLG1 DRD2 DRD3
13 visual learning GO:0008542 9.84 DBH DRD1 DRD2 DRD3
14 negative regulation of adenylate cyclase activity GO:0007194 9.83 DRD2 DRD3 DRD4
15 associative learning GO:0008306 9.8 DBH DRD1 DRD2
16 arachidonic acid secretion GO:0050482 9.79 DRD2 DRD3 DRD4
17 regulation of dopamine secretion GO:0014059 9.79 DRD2 DRD3 HTR2A
18 temperature homeostasis GO:0001659 9.78 DRD1 DRD2 HTR2A
19 dopamine receptor signaling pathway GO:0007212 9.78 DRD1 DRD2 DRD3 DRD4
20 behavioral response to ethanol GO:0048149 9.77 DBH DRD2 DRD4
21 prepulse inhibition GO:0060134 9.75 DRD1 DRD2 DRD3
22 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.74 DRD2 DRD3 DRD4
23 negative regulation of lipid catabolic process GO:0050995 9.73 INS TNF
24 regulation of protein secretion GO:0050708 9.73 INS TNF
25 positive regulation of kinase activity GO:0033674 9.73 DRD4 HTR2A
26 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.72 DRD2 HTR2A
27 neurotransmitter biosynthetic process GO:0042136 9.72 SLC6A4 TH
28 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.72 DRD1 DRD2
29 maternal behavior GO:0042711 9.72 DBH DRD1
30 peristalsis GO:0030432 9.72 DLG1 DRD1 DRD2
31 response to cocaine GO:0042220 9.72 DNMT3B DRD1 DRD2 DRD3 HTR3A
32 negative regulation of voltage-gated calcium channel activity GO:1901386 9.71 DRD2 DRD4
33 grooming behavior GO:0007625 9.71 DRD1 DRD2
34 positive regulation of renal sodium excretion GO:0035815 9.71 DRD2 DRD3
35 G-protein coupled receptor internalization GO:0002031 9.71 DRD2 DRD3
36 striatum development GO:0021756 9.71 DRD1 DRD2
37 synaptic transmission, dopaminergic GO:0001963 9.71 DRD1 DRD2 DRD3 TH
38 neurotransmitter catabolic process GO:0042135 9.7 COMT MAOA
39 positive regulation of potassium ion transport GO:0043268 9.7 DLG1 DRD1
40 catecholamine metabolic process GO:0006584 9.7 COMT MAOA
41 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.7 DRD1 DRD3
42 dopamine catabolic process GO:0042420 9.7 COMT DBH MAOA
43 regulation of dopamine metabolic process GO:0042053 9.69 DRD1 DRD4
44 cellular response to nicotine GO:0071316 9.69 TH TNF
45 response to salt stress GO:0009651 9.69 TH TNF
46 mating behavior GO:0007617 9.68 DRD1 TH
47 regulation of protein phosphorylation GO:0001932 9.68 NDUFS4 TNF
48 regulation of cAMP metabolic process GO:0030814 9.67 DRD2 DRD3
49 catecholamine biosynthetic process GO:0042423 9.67 DBH TH
50 norepinephrine biosynthetic process GO:0042421 9.67 DBH TH

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.77 DRD1 DRD2 DRD3 DRD4 HTR2A
2 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 HTR2A
3 monooxygenase activity GO:0004497 9.5 DBH TH YWHAH
4 insulin-like growth factor receptor binding GO:0005159 9.43 INS YWHAH
5 serotonin binding GO:0051378 9.4 HTR2A HTR3A
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
7 dopamine neurotransmitter receptor activity GO:0004952 9.26 DRD1 DRD2 DRD3 DRD4
8 dopamine binding GO:0035240 9.02 DRD1 DRD2 DRD3 DRD4 TH

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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