MCID: ERL020
MIFTS: 47

Early-Onset Schizophrenia malady

Categories: Neuronal diseases, Rare diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

Aliases & Descriptions for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 56
Early Onset Schizophrenia 69

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA96369
ICD10 via Orphanet 34 F20.8

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to autism spectrum disorder and substance-induced psychosis. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Beta-Adrenergic Signaling. The drugs Dopamine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cingulate cortex, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 17 Schizophrenia 16
Schizophrenia 10 Schizophrenia 4
Schizophrenia 15 Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 autism spectrum disorder 29.7 BDNF COMT DRD4 SLC6A4
2 substance-induced psychosis 29.5 BDNF INS TH TNF
3 schizophrenia 28.3 BDNF COMT DBH DLG1 DRD1 DRD2
4 allergic hypersensitivity disease 10.2 DRD2 HTR2A NDUFS4
5 vascular cancer 10.2 DRD2 HTR2A NDUFS4
6 splenic abscess 10.2 DRD2 HTR2A SLC6A4
7 euthyroid sick syndrome 10.2 DRD2 HTR2A SLC6A4
8 waardenburg's syndrome 10.2 DRD2 HTR2A SLC6A4
9 neurogenic bladder 10.1 HTR2A MAOA SLC6A4
10 nephronophthisis 13 10.1 COMT HTR2A SLC6A4
11 urea cycle disorder 10.1 BDNF COMT DRD2
12 spinal meningioma 10.1 DRD2 HTR2A SOX10
13 apperceptive agnosia 10.1 COMT DRD2 SLC6A4
14 limb ischemia 10.1 HTR2A INS TNF
15 breast reconstruction 10.1 BDNF COMT DRD2
16 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.1 BDNF COMT HTR2A SLC6A4
17 lethal congenital contracture syndrome 1 10.0 COMT MAOA TH
18 cholesteatoma 10.0 BDNF COMT DRD2 SLC6A4
19 interstitial emphysema 10.0 DBH DRD2 SLC6A4
20 basal cell carcinoma 3 10.0 COMT DRD2 HTR2A MAOA
21 diabetic encephalopathy 10.0 HTR2A INS TNF
22 chronic eosinophilic pneumonia 10.0 BDNF COMT MAOA SLC6A4
23 ovarian mucinous adenocarcinoma 10.0 BDNF TH TNF
24 hypoglycemic coma 10.0 BDNF HTR2A INS MAOA SLC6A4
25 strongyloidiasis 10.0 COMT DRD2 MAOA SLC6A4
26 primary angle-closure glaucoma 10.0 BDNF COMT DRD1 HTR2A SLC6A4
27 bipolar disorder 10.0
28 tuberculous peritonitis 10.0 HTR3A SLC6A4 TNF
29 pythiosis 10.0 DBH MAOA TH
30 hepatitis b reinfection following liver transplantation 10.0 HTR2A HTR3A MAOA SLC6A4
31 ornithosis 10.0 DRD2 HTR3A MAOA SLC6A4
32 epithelioid type angiomyolipoma 10.0 BDNF HTR2A SLC6A4 TH TNF
33 parotid gland cancer 10.0 COMT DRD1 DRD2 HTR2A TNF
34 intrahepatic gall duct cancer 10.0 BDNF COMT HTR2A MAOA SLC6A4
35 multiple personality disorder 9.9 BDNF COMT HTR2A MAOA SLC6A4
36 keratosis 9.9 BDNF COMT HTR2A MAOA SLC6A4
37 teratoma with malignant transformation 9.9 BDNF DRD2 DRD3 HTR2A
38 cerebritis 9.9
39 neuronitis 9.9
40 lichen disease 9.9 COMT HTR2A MAOA SLC6A4 TNF
41 intracranial aneurysm 9.9 DRD2 DRD3 DRD4
42 nephrogenic adenoma of the urethra 9.9 DBH DRD2 HTR3A SLC6A4
43 suppurative periapical periodontitis 9.9 DRD2 DRD3 TH
44 chagas disease 9.9 BDNF COMT HTR2A HTR3A SLC6A4
45 hereditary multiple exostoses 9.9 BDNF COMT DRD2 HTR2A MAOA SLC6A4
46 carotid stenosis 9.8 COMT DRD2 DRD4 MAOA SLC6A4
47 ischemic neuropathy 9.8 DRD2 DRD3 HTR3A
48 fechtner syndrome 9.8 COMT HTR2A HTR3A MAOA SLC6A4
49 hypoglycemia 9.8 BDNF DRD1 DRD2 DRD3 SLC6A4
50 postencephalitic parkinson disease 9.8 BDNF DRD2 HTR2A HTR3A MAOA SLC6A4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

GenomeRNAi Phenotypes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 COMT DLG1 DRD1 DRD2 DRD3 DRD4

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 DBH DRD1 BDNF DLG1 COMT TNF
2 homeostasis/metabolism MP:0005376 10.36 COMT DRD1 DBH BDNF DLG1 SLC6A4
3 growth/size/body region MP:0005378 10.32 DNMT3B DRD1 DBH DLG1 BDNF SLC6A4
4 endocrine/exocrine gland MP:0005379 10.31 COMT DBH BDNF DLG1 DNMT3B TNF
5 cardiovascular system MP:0005385 10.3 COMT DRD1 DBH DNMT3B SLC6A4 TNF
6 mortality/aging MP:0010768 10.25 DNMT3B DBH BDNF DLG1 SLC6A4 SOX10
7 nervous system MP:0003631 10.25 DBH DRD1 BDNF DLG1 DNMT3B COMT
8 integument MP:0010771 10.17 DRD1 DBH BDNF SLC6A4 TNF SOX10
9 digestive/alimentary MP:0005381 10.16 DRD1 DLG1 BDNF SOX10 INS DRD3
10 adipose tissue MP:0005375 10.02 DBH DRD3 INS DRD1 DRD2 TNF
11 muscle MP:0005369 10.02 DLG1 SLC6A4 NDUFS4 INS DRD1 HTR2A
12 normal MP:0002873 9.81 DBH BDNF SLC6A4 SOX10 NDUFS4 TH
13 no phenotypic analysis MP:0003012 9.8 DNMT3B DLG1 BDNF TH INS DRD2
14 respiratory system MP:0005388 9.61 COMT DRD1 DLG1 BDNF TNF SOX10
15 vision/eye MP:0005391 9.32 DNMT3B DRD1 DBH DLG1 BDNF TNF

Drugs & Therapeutics for Early-Onset Schizophrenia

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Molindone Approved Phase 4 7416-34-4 23897
5
Serotonin Phase 4,Phase 2 50-67-9 5202
6 Serotonin Agents Phase 4,Phase 2
7 Serotonin Antagonists Phase 4,Phase 2
8 Serotonin Uptake Inhibitors Phase 4
9 Gastrointestinal Agents Phase 4
10 Neurotransmitter Agents Phase 4,Phase 2
11 Neurotransmitter Uptake Inhibitors Phase 4
12 Tranquilizing Agents Phase 4,Phase 2
13 Peripheral Nervous System Agents Phase 4
14 Dopamine Agents Phase 4,Phase 2
15 Dopamine Antagonists Phase 4,Phase 2
16 Antiemetics Phase 4
17 Psychotropic Drugs Phase 4,Phase 2
18 Antipsychotic Agents Phase 4,Phase 2
19 Autonomic Agents Phase 4
20 Central Nervous System Depressants Phase 4,Phase 2
21 Immunoglobulins Phase 3
22 gamma-Globulins Phase 3
23 Immunoglobulins, Intravenous Phase 3
24 Rho(D) Immune Globulin Phase 3
25 Antibodies Phase 3
26
Ziprasidone Approved Phase 2 146939-27-7 60854
27
Heparin Approved, Investigational 9005-49-6 772 46507594
28
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
29
Diazepam Approved, Illicit, Vet_approved 439-14-5 3016
30
Epinephrine Approved, Vet_approved 51-43-4 5816
31
Midazolam Approved, Illicit 59467-70-8 4192
32
Nicardipine Approved 55985-32-5 4474
33
Ciprofloxacin Approved, Investigational 85721-33-1 2764
34
Morphine Approved, Investigational 57-27-2 5288826
35
Cidofovir Approved 113852-37-2 60613
36
Valproic Acid Approved, Investigational 99-66-1 3121
37
Warfarin Approved 81-81-2 6691 54678486
38
Haloperidol Approved 52-86-8 3559
39
Topiramate Approved 97240-79-4 5284627
40
Clozapine Approved 5786-21-0 2818
41
Timolol Approved 26839-75-8 33624 5478
42
Prednisolone Approved, Vet_approved 50-24-8 5755
43
Fosphenytoin Approved 93390-81-9 56339
44
Tobramycin Approved, Investigational 32986-56-4 5496 36294
45
Oseltamivir Approved 204255-11-8, 196618-13-0 65028
46
Pentobarbital Approved, Vet_approved 76-74-4 4737
47
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
48
Alfentanil Approved, Illicit 71195-58-9 51263
49
Aripiprazole Approved, Investigational 129722-12-9 60795
50
Hydromorphone Approved, Illicit 466-99-9 5284570

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS) Completed NCT00053703 Phase 4
2 Efficacy Study of Early Onset of Antipsychotic Drug Action in Schizophrenia Completed NCT00337662 Phase 4
3 Treatment With Risperidone Long Acting Injectable (RLAI) in an Early Phase of Psychosis Completed NCT00369239 Phase 4
4 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia Recruiting NCT02435654 Phase 4
5 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3
6 Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis Unknown status NCT00465920 Phase 2
7 Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders Unknown status NCT02097563 Phase 2
8 Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Completed NCT01006551 Phase 2
9 Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS) Completed NCT02764164
10 Cognitive Remediation Therapy (CRT) in Adolescents With EOS Completed NCT01701609
11 Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia Completed NCT01781364
12 Intensive Computerized Brain Training (ICBT) in Youth With Early Onset Psychosis (EOP) Completed NCT01027962
13 Sex Differences in Early Brain Development; Brain Development in Turner Syndrome Completed NCT00877942
14 Reward Processing in Schizophrenia Recruiting NCT03068793
15 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Recruiting NCT01431326
16 Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia Recruiting NCT00001198
17 Integrated Prevention and Collaborative Care for Youth Mental Health Recruiting NCT03114007
18 Aripiprazole Treatment of the Prodrome Terminated NCT00169949

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

39
Brain, Cortex, Cingulate Cortex, Temporal Lobe, Testes, Thalamus, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 200)
id Title Authors Year
1
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
2
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
3
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2016
4
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. ( 27000303 )
2016
5
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
6
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
7
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
8
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
9
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
10
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
11
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
12
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. ( 25840049 )
2015
13
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. ( 26001923 )
2015
14
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. ( 25967042 )
2015
15
Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia. ( 26071585 )
2015
16
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. ( 26297473 )
2015
17
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. ( 26230626 )
2015
18
Assessing and Treating Early Onset Schizophrenia at Schools. ( 26101010 )
2015
19
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. ( 26440542 )
2015
20
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
21
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
22
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. ( 26484249 )
2015
23
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2015
24
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
25
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. ( 25999041 )
2015
26
Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial. ( 25062593 )
2014
27
White matter abnormalities and cognitive impairment in early-onset schizophrenia-spectrum disorders. ( 24565363 )
2014
28
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study. ( 24831926 )
2014
29
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. ( 25520226 )
2014
30
Systematic review of the efficacy and tolerability of Clozapine in the treatment of youth with early onset schizophrenia. ( 24119631 )
2014
31
Patterns and correlates of expressed emotion, perceived criticism, and rearing style in first admitted early-onset schizophrenia spectrum disorders. ( 25259947 )
2014
32
Relative stability of neurocognitive deficits in early onset schizophrenia spectrum patients. ( 24811433 )
2014
33
Brain network informed subject community detection in early-onset schizophrenia. ( 24989351 )
2014
34
Adolescent insanity revisited: course and outcome in early-onset schizophrenia spectrum psychoses in an 8-year follow-up study. ( 24794640 )
2014
35
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. ( 25130214 )
2014
36
The When and Where of Working Memory Dysfunction in Early-Onset Schizophrenia--A Functional Magnetic Resonance Imaging Study. ( 24675869 )
2014
37
Different and Shared Brain Volume Abnormalities in Late- and Early-Onset Schizophrenia. ( 25358262 )
2014
38
Neuropsychological deficits in the prodromal phase and course of an early-onset schizophrenia. A case report. ( 24846865 )
2014
39
Profile of cognitive deficits and associations with depressive symptoms and intelligence in chronic early-onset schizophrenia patients. ( 23786210 )
2013
40
Age-related cortical thickness differences in adolescents with early-onset schizophrenia compared with healthy adolescents. ( 24144503 )
2013
41
Aberrant default mode functional connectivity in early onset schizophrenia. ( 23923052 )
2013
42
Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report. ( 23714054 )
2013
43
Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach. ( 23364281 )
2013
44
Health service registry data in psychiatric epidemiology: challenges for definition and interpretation: an editorial comment to: Okkels et al.'s 'changes in the diagnosed incidence of early onset schizophrenia over four decades' (1). ( 23240595 )
2013
45
Reduced lateralization in early onset schizophrenia. ( 23370283 )
2013
46
Metabolic changes in first-episode early-onset schizophrenia with second-generation antipsychotics. ( 23968390 )
2013
47
T102C polymorphism of serotonin 2A type receptor gene confers susceptibility to (early onset) schizophrenia in Han Chinese: an association study and meta-analysis. ( 23857788 )
2013
48
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. ( 23384737 )
2013
49
Hematological and cardiometabolic safety of clozapine in the treatment of very early onset schizophrenia: a retrospective chart review. ( 24111981 )
2013
50
Clozapine augmented with amisulpride in 3 cases of treatment-resistant early- and very early-onset schizophrenia. ( 23764685 )
2013

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 BDNF DNMT3B DRD1 DRD2 INS MAOA
2
Show member pathways
12.7 BDNF DRD1 DRD2 DRD3 DRD4 INS
3
Show member pathways
12.64 COMT DRD1 DRD2 DRD3 DRD4 MAOA
4 12.21 DRD1 DRD2 DRD3 DRD4
6 11.9 HTR2A HTR3A MAOA SLC6A4
7
Show member pathways
11.87 BDNF DRD1 DRD2 MAOA TH
8
Show member pathways
11.83 DRD2 DRD3 DRD4 TH
9
Show member pathways
11.83 DRD1 DRD2 DRD3 DRD4 HTR2A
10 11.78 DRD3 DRD4 HTR2A
11 11.71 DBH MAOA TH
12
Show member pathways
11.67 COMT DBH MAOA TH
13 11.65 BDNF SOX10 TH
14 11.44 BDNF HTR2A HTR3A MAOA SLC6A4 TH
15
Show member pathways
11.14 COMT MAOA SLC6A4
16 11.08 DRD1 DRD2 DRD3
17 11 HTR2A HTR3A MAOA SLC6A4
18
Show member pathways
10.99 DBH MAOA SLC6A4 TH TNF
19 10.8 COMT MAOA TH
20
Show member pathways
10.8 COMT DBH MAOA TH
21
Show member pathways
10.73 COMT MAOA

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 DRD1 DRD2 DRD3 DRD4 HTR2A SLC6A4
2 axon GO:0030424 9.02 COMT DRD2 HTR2A HTR3A TH

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.96 DNMT3B DRD2 SLC6A4 TH
2 response to ethanol GO:0045471 9.93 DRD2 DRD3 HTR3A TH
3 response to toxic substance GO:0009636 9.91 DNMT3B DRD2 SLC6A4
4 locomotory behavior GO:0007626 9.91 DBH DRD1 DRD2 DRD3 TH
5 response to estradiol GO:0032355 9.9 DNMT3B SLC6A4 TH
6 cellular calcium ion homeostasis GO:0006874 9.9 DRD3 DRD4 HTR2A
7 learning GO:0007612 9.88 COMT DRD1 DRD3 TH
8 social behavior GO:0035176 9.87 DRD3 DRD4 SLC6A4 TH
9 response to drug GO:0042493 9.86 COMT DNMT3B DRD1 DRD2 DRD3 HTR2A
10 synapse assembly GO:0007416 9.85 BDNF DRD1 DRD2
11 memory GO:0007613 9.85 DBH DRD1 HTR2A SLC6A4 TH
12 visual learning GO:0008542 9.84 DBH DRD1 DRD2 DRD3
13 negative regulation of protein kinase B signaling GO:0051898 9.83 DLG1 DRD2 DRD3
14 associative learning GO:0008306 9.8 DBH DRD1 DRD2
15 negative regulation of adenylate cyclase activity GO:0007194 9.8 DRD2 DRD3 DRD4
16 arachidonic acid secretion GO:0050482 9.79 DRD2 DRD3 DRD4
17 regulation of dopamine secretion GO:0014059 9.78 DRD2 DRD3 HTR2A
18 dopamine receptor signaling pathway GO:0007212 9.78 DRD1 DRD2 DRD3 DRD4
19 temperature homeostasis GO:0001659 9.77 DRD1 DRD2 HTR2A
20 behavioral response to ethanol GO:0048149 9.77 DBH DRD2 DRD4
21 prepulse inhibition GO:0060134 9.75 DRD1 DRD2 DRD3
22 negative regulation of lipid catabolic process GO:0050995 9.73 INS TNF
23 regulation of protein secretion GO:0050708 9.73 INS TNF
24 positive regulation of kinase activity GO:0033674 9.73 DRD4 HTR2A
25 peristalsis GO:0030432 9.73 DLG1 DRD1 DRD2
26 positive regulation of glycolytic process GO:0045821 9.72 HTR2A INS
27 neurotransmitter biosynthetic process GO:0042136 9.72 SLC6A4 TH
28 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.72 DRD2 HTR2A
29 maternal behavior GO:0042711 9.72 DBH DRD1
30 grooming behavior GO:0007625 9.72 DRD1 DRD2
31 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.72 DRD2 DRD3 DRD4
32 response to cocaine GO:0042220 9.72 DNMT3B DRD1 DRD2 DRD3 HTR3A
33 positive regulation of renal sodium excretion GO:0035815 9.71 DRD2 DRD3
34 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.71 DRD1 DRD2
35 negative regulation of voltage-gated calcium channel activity GO:1901386 9.71 DRD2 DRD4
36 G-protein coupled receptor internalization GO:0002031 9.71 DRD2 DRD3
37 striatum development GO:0021756 9.71 DRD1 DRD2
38 synaptic transmission, dopaminergic GO:0001963 9.71 DRD1 DRD2 DRD3 TH
39 neurotransmitter catabolic process GO:0042135 9.7 COMT MAOA
40 positive regulation of potassium ion transport GO:0043268 9.7 DLG1 DRD1
41 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.7 DRD1 DRD3
42 catecholamine metabolic process GO:0006584 9.7 COMT MAOA
43 dopamine catabolic process GO:0042420 9.7 COMT DBH MAOA
44 regulation of dopamine metabolic process GO:0042053 9.69 DRD1 DRD4
45 response to salt stress GO:0009651 9.69 TH TNF
46 cellular response to nicotine GO:0071316 9.69 TH TNF
47 mating behavior GO:0007617 9.68 DRD1 TH
48 serotonin receptor signaling pathway GO:0007210 9.68 HTR2A HTR3A
49 regulation of cAMP metabolic process GO:0030814 9.68 DRD2 DRD3
50 norepinephrine biosynthetic process GO:0042421 9.67 DBH TH

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.77 DRD1 DRD2 DRD3 DRD4 HTR2A
2 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 HTR2A
3 monooxygenase activity GO:0004497 9.5 DBH TH YWHAH
4 insulin-like growth factor receptor binding GO:0005159 9.43 INS YWHAH
5 serotonin binding GO:0051378 9.4 HTR2A HTR3A
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
7 dopamine neurotransmitter receptor activity GO:0004952 9.26 DRD1 DRD2 DRD3 DRD4
8 dopamine binding GO:0035240 9.02 DRD1 DRD2 DRD3 DRD4 TH

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....