MCID: ERL020
MIFTS: 44

Early-Onset Schizophrenia malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

About this section

Aliases & Descriptions for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 52

Classifications:



External Ids:

Orphanet52 ORPHA96369

Summaries for Early-Onset Schizophrenia

About this section
MalaCards based summary: Early-Onset Schizophrenia is related to schizophrenia and kernicterus due to isoimmunization. An important gene associated with Early-Onset Schizophrenia is DNMT3B (DNA Methyltransferase 3 Beta), and among its related pathways are Enzymatic degradation of Dopamine by monoamine oxidase and Neurotransmitter Clearance In The Synaptic Cleft. Affiliated tissues include brain, cortex and cingulate cortex, and related mouse phenotypes are adipose tissue and reproductive system.

Related Diseases for Early-Onset Schizophrenia

About this section

Diseases in the Schizophrenia family:

Schizophrenia 17 Schizophrenia 16
Schizophrenia 10 Schizophrenia 4
Schizophrenia 15 early-onset schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia26.9BDNF, COMT, DBH, DRD1, DRD2, DRD3
2kernicterus due to isoimmunization10.5DRD2, HTR2A, NDUFS4
3vascular cancer10.5DRD2, HTR2A, NDUFS4
4c8 deficiency, type ii10.5DRD1, DRD2, DRD4
5brain meningioma10.4BDNF, COMT, DRD2
6erysipelas10.4COMT, DRD2
7basal cell carcinoma10.4DRD2, SLC6A4
8antisocial personality disorder10.4DRD2, DRD3, DRD4
9limb ischemia10.4BDNF, INS
10acute female pelvic peritonitis10.4DRD2, DRD4, MAOA
11ring chromosome 14 syndrome10.3COMT, MAOA
12dissociative disorder10.3DRD3, SLC6A4
13cocaine dependence10.3BDNF, DRD2, MAOA
14splenic disease10.3DRD2, HTR2A, SLC6A4
15breast hemangioma10.3DRD1, DRD2
16braddock jones superneau syndrome10.2DBH, TH
17anosognosia10.2COMT, DRD2, SLC6A4
18neurodegeneration with optic atrophy, childhood onset10.2COMT, HTR2A, SLC6A4
19repetitive motion disorders10.2DBH, INS
20hemangioma of intra-abdominal structure10.2INS, TNF
21hallucinogen dependence10.2DRD2, DRD3, SLC6A4
22chagas disease10.2HTR2A, MAOA, SLC6A4
23lipedematous scalp10.2COMT, DRD2, DRD3, HTR2A
24laryngeal adductor paralysis10.2DRD4, HTR2A, SLC6A4
25gnathomiasis10.2DRD2, HTR2A, SOX10
26morphine dependence10.1DRD2, DRD3, TH
27intrahepatic gall duct cancer10.1MAOA, SLC6A4
28pelvic inflammatory disease10.1DBH, DRD2, SLC6A4
29bipolar disorder10.1
30ulcerative colitis10.1BDNF, COMT, DRD2, SLC6A4
31lymphosarcoma10.1BDNF, COMT, DRD2, SLC6A4
32rabies10.0HTR3A, MAOA, SLC6A4
33cerebritis10.0
34neuronitis10.0
35papillary serous adenocarcinoma10.0BDNF, HTR3A, TH
36lymphadenitis10.0BDNF, INS, MAOA, SLC6A4
37acatalasemia10.0BDNF, COMT, HTR2A, SLC6A4
38pervasive developmental disorder10.0BDNF, COMT, DRD4, SLC6A4
39polycystic kidney disease 210.0DBH, DRD2, TH
40meckel's diverticulum10.0BDNF, COMT, MAOA, SLC6A4
41autism spectrum disorder10.0
42tongue disease10.0COMT, DRD2, MAOA, SLC6A4
43bone fracture10.0BDNF, DRD3, TH, YWHAH
44adult spinal cord ependymoma9.9DRD2, DRD3, DRD4, TH
45autoimmune-related retinopathy and optic neuropathy9.9HTR2A, HTR3A, SLC6A4
46heroin dependence9.8BDNF, DRD1, DRD2, DRD3, SLC6A4
47phaeohyphomycosis9.8BDNF, COMT, DRD1, HTR2A, SLC6A4
48dysthymic disorder9.8BDNF, DRD4, HTR2A, INS, SLC6A4
49idiopathic neonatal atrial flutter9.8HTR2A, HTR3A, MAOA, SLC6A4
50conjunctival degeneration9.8HTR2A, SLC6A4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to early-onset schizophrenia

Symptoms for Early-Onset Schizophrenia

About this section

Drugs & Therapeutics for Early-Onset Schizophrenia

About this section

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SerotoninPhase 4, Phase 2351050-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
2
DopaminePhase 4, Phase 2367851-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3
RisperidonePhase 4482106266-06-25073
Synonyms:
106266-06-2
3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
AB00514010
AC-1306
AC1L1JJU
BIDD:GT0262
BRD-K53857191-001-04-5
BRN 4891881
Belivon
Bio-0092
Buspirone
C23H27FN4O2
CAS-106266-06-2
CHEBI:8871
CHEMBL85
CID5073
CPD000466323
Consta, Risperdal
D00426
D018967
DB00734
EU-0101074
HMS1571M19
HMS2051H07
HMS2089C22
HSDB 7580
I01-1156
Jsp000573
KS-1106
L000510
LS-134196
Lopac-R-118
MLS000759429
MLS001165758
MLS001424081
MolPort-002-885-858
 
NCGC00015883-01
NCGC00015883-02
NCGC00015883-03
NCGC00094352-01
NCGC00094352-02
NCGC00094352-03
NCGC00179257-01
Prestwick0_001029
Prestwick1_001029
R 62 766
R 64 766, Risperdal, Risperidone
R 64,766
R 64766
R-118
R-64,766
R-64-766
R-64766
R64,766
R64766
Rispen
Risperdal
Risperdal (TN)
Risperdal Consta
Risperdal M-Tab
Risperidal
Risperidal M-Tab
Risperidona
Risperidona [Spanish]
Risperidone
Risperidone (JAN/USAN/INN)
Risperidone (RIS)
Risperidone [USAN:BAN:INN]
Risperidone, placebo
Risperidonum
Risperidonum [Latin]
Risperin
Rispolept
Rispolin
S1615_Selleck
SAM001246595
SMR000466323
SPBio_003078
STK646402
Sequinan
Spiron
TL8000230
UNII-L6UH7ZF8HC
risperdone
risperidone
4
OlanzapinePhase 4384132539-06-14585
Synonyms:
132539-06-1
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10 H -thieno[2,3- b ] [1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
AC-665
AC1L1IHS
AKOS000282888
ALKS-7921
BIDD:GT0332
BIDD:PXR0138
Bio-0169
C07322
C076029
C17H20N4S
CHEBI:7735
CHEMBL715
CID4585
CPD000466345
D00454
DB00334
Eli Lilly brand of olanzapine
HMS2051H05
HMS2089M04
HMS2093I04
I06-0784
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
Jsp001969
KS-1090
L000455
L005958
LS-152313
LY 170053
LY-170052
 
LY-170053
Lanzac
Lilly brand of olanzapine
MLS000759457
MLS001165781
MLS001195646
MLS001424057
Midax
MolPort-002-885-845
MolPort-003-666-569
MolPort-005-977-341
NCGC00096077-01
NCGC00096077-03
NCGC00096077-04
Olansek
Olanzapin
Olanzapina
Olanzapine
Olanzapine (JAN/USAN/INN)
Olanzapine (OLA)
Olanzapine [USAN:INN]
Olanzapinum
S2493_Selleck
SAM001246652
SMR000466345
SPECTRUM1505024
STK634338
Symbyax
TL8000772
UNII-N7U69T4SZR
Zalasta
Zydis
Zyprexa
Zyprexa (TN)
Zyprexa Intramuscular
Zyprexa Velotab
Zyprexa Zydis
olanzapina
olanzapine
olanzapinum
5
MolindonePhase 427416-34-423897
Synonyms:
(+-)-Molindone
(+-)-molindone
15622-65-8 (mono-hydrochloride)
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
65973-37-7
7416-34-4
AB00514709
AC-7052
AC1L2N2H
AC1Q2SRY
AC1Q6J6B
BPBio1_001374
BRD-A65280694-003-03-8
BSPBio_001249
C07230
C16H24N2O2
CHEBI:103799
CHEMBL460
CID23897
D08226
DB01618
HSDB 3131
 
I14-11948
L001248
LS-83891
MOLINDONE
Moban
MolPort-005-940-887
Molindona
Molindona [INN-Spanish]
Molindona [inn-spanish]
Molindone
Molindone (INN)
Molindone (MOL)
Molindone Monohydrochloride
Molindone [INN:BAN]
Molindonum
Molindonum [INN-Latin]
Molindonum [inn-latin]
NCGC00162218-01
NCGC00162218-02
NCGC00162218-03
Oprea1_038890
Prestwick0_001035
Prestwick1_001035
Prestwick2_001035
Prestwick3_001035
SPBio_003100
UNII-RT3Y3QMF8N
6
ZiprasidonePhase 2141146939-27-760854
Synonyms:
138982-67-9 (hydrochloride monohydrate)
146939-27-7
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
6-chloro-5-[2-[4-(7-thia-8-azabicyclo[4.3.0]nona-1,3,5,8-tetraen-9-yl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one
AC1L1U27
Ambap122883-93-6
BIDD:GT0042
C07568
C21H21ClN4OS
CHEBI:10119
CHEMBL708
CID60854
CP 88059
CP 88059-01
CP-88,059
CP-88,059-01
CP-88,059-1
CP-88059-1
CPD000466328
D08687
DB00246
 
Geodon
Geodon Oral
I14-0766
L000659
LS-83744
MLS000759435
MolPort-003-850-885
SAM001246607
SMR000466328
TL8000889
UNII-6UKA5VEJ6X
Zeldox
Zipradon
Zipradon (TN)
Ziprasidona
Ziprasidone
Ziprasidone (INN)
Ziprasidone [INN:BAN]
Ziprasidone hydrochloride
Ziprasidone mesylate trihydrate
Ziprasidonum
ziprasidona
ziprasidonum
ziprazidone
7
Aripiprazole345129722-12-960795
Synonyms:
129722-12-9
24-29-3
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
AC-1554
AC1L1TXZ
AC1Q3T38
ALKS-9070
Abilify
Abilify (TN)
Abilify Discmelt
Abilitat
Aripiprazol
Aripiprazole
Aripiprazole (JAN/USAN/INN)
Aripiprazole [USAN]
Aripiprazolum
Aripirazole
Arpizol
Asprito|
BMS-337039
Bio-0004
Bristol-Myers Squibb brand of aripiprazole
C094645
C12564
C23H27Cl2N3O2
CHEBI:31236
CHEMBL1112
CID60795
CPD000466383
 
D01164
DB01238
Discmelt
FT-0082572
HMS2051I18
HMS2089M20
HMS2093F22
HSDB 7320
KS-1030
L001339
LS-142666
MLS000759517
MLS001165779
MLS001195621
MLS001424078
MolPort-002-885-808
MolPort-003-844-657
NCGC00159510-02
NCGC00159510-03
OPC 31
OPC-14597
OPC-31
Opc 14597
Otsuka brand of aripiprazole
Pripiprazole
S06-0010
SAM001246750
SMR000466383
STK625160
TL8000707
TL80090184
UNII-82VFR53I78
aripiprazol
aripiprazole
aripiprazolum
||OPC 14597

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS)CompletedNCT00053703Phase 4
2Efficacy Study of Early Onset of Antipsychotic Drug Action in SchizophreniaCompletedNCT00337662Phase 4
3Treatment With Risperidone Long Acting Injectable (RLAI) in an Early Phase of PsychosisCompletedNCT00369239Phase 4
45-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset SchizophreniaRecruitingNCT02435654Phase 4
5Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
6Ziprasidone in Early Onset Schizophrenia Spectrum DisordersCompletedNCT01006551Phase 2
7Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset PsychosisRecruitingNCT00465920Phase 2
8Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic DisordersNot yet recruitingNCT02097563Phase 2
9Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS)CompletedNCT02764164
10Cognitive Remediation Therapy (CRT) in Adolescents With EOSCompletedNCT01701609
11Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission SchizophreniaCompletedNCT01781364
12Intensive Computerized Brain Training (ICBT) in Youth With Early Onset Psychosis (EOP)CompletedNCT01027962
13Sex Differences in Early Brain Development; Brain Development in Turner SyndromeCompletedNCT00877942
14Evaluating Genetic Risk Factors for Childhood-Onset SchizophreniaRecruitingNCT00001198
15Aripiprazole Treatment of the ProdromeTerminatedNCT00169949

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

About this section

Anatomical Context for Early-Onset Schizophrenia

About this section

MalaCards organs/tissues related to Early-Onset Schizophrenia:

34
Brain, Cortex, Cingulate cortex, Temporal lobe, Testes, Thalamus, Prefrontal cortex

Animal Models for Early-Onset Schizophrenia or affiliated genes

About this section

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

39 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9DBH, DRD1, DRD2, DRD3, INS, TNF
2MP:00053898.2BDNF, COMT, DLG1, DNMT3B, DRD2, HTR3A
3MP:00030128.0BDNF, DLG1, DNMT3B, DRD2, INS, TH
4MP:00053907.9DBH, DLG1, DNMT3B, DRD2, HTR2A, INS
5MP:00053697.8DLG1, DRD1, DRD2, HTR2A, HTR3A, INS
6MP:00053817.7BDNF, DLG1, DRD1, DRD2, DRD3, HTR2A
7MP:00028737.5BDNF, DBH, DRD1, DRD2, INS, NDUFS4
8MP:00053887.3BDNF, COMT, DLG1, DRD1, DRD2, NDUFS4
9MP:00053847.2BDNF, DLG1, DNMT3B, DRD1, DRD2, INS
10MP:00107717.0BDNF, DBH, DRD1, DRD2, HTR3A, INS
11MP:00053916.9BDNF, DBH, DLG1, DNMT3B, DRD1, DRD4
12MP:00053856.5COMT, DBH, DNMT3B, DRD1, DRD2, DRD3
13MP:00053795.6BDNF, COMT, DBH, DLG1, DNMT3B, DRD2
14MP:00107685.6BDNF, DBH, DLG1, DNMT3B, DRD1, DRD2
15MP:00053785.3BDNF, DBH, DLG1, DNMT3B, DRD1, DRD2
16MP:00036314.7BDNF, COMT, DBH, DLG1, DNMT3B, DRD1
17MP:00053764.3BDNF, COMT, DBH, DLG1, DRD1, DRD2
18MP:00053864.3BDNF, COMT, DBH, DLG1, DRD1, DRD2

Publications for Early-Onset Schizophrenia

About this section

Articles related to Early-Onset Schizophrenia:

(show top 50)    (show all 197)
idTitleAuthorsYear
1
Time perception of simultaneous and sequential events in early-onset schizophrenia. (27388526)
2016
2
Altered expression of mRNA profiles in blood of early-onset schizophrenia. (26733343)
2016
3
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. (26916502)
2016
4
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. (27384868)
2016
5
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. (26001923)
2015
6
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. (25840049)
2015
7
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. (25130214)
2014
8
Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial. (25062593)
2014
9
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. (25520226)
2014
10
Systematic review of the efficacy and tolerability of Clozapine in the treatment of youth with early onset schizophrenia. (24119631)
2014
11
Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study. (24831926)
2014
12
Relative stability of neurocognitive deficits in early onset schizophrenia spectrum patients. (24811433)
2014
13
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
14
Aberrant default mode functional connectivity in early onset schizophrenia. (23923052)
2013
15
Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings. (24012081)
2013
16
Changes in the diagnosed incidence of early onset schizophrenia over four decades. (22906158)
2013
17
Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report. (23714054)
2013
18
Visual backward-masking performance in a longitudinal study of early onset schizophrenia. (22673182)
2012
19
Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities. (22917502)
2012
20
Early-onset schizophrenia. (22797279)
2012
21
A meta-analysis of neuropsychological functioning in patients with early onset schizophrenia and pediatric bipolar disorder. (21391023)
2011
22
Brain functional connectivity of functional magnetic resonance imaging of patients with early-onset schizophrenia. (20130360)
2010
23
Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study. (20494268)
2010
24
Deficient maturation of aspects of attention and executive functions in early onset schizophrenia. (20680364)
2010
25
Neurocognition in early-onset schizophrenia and schizoaffective disorders. (20215926)
2010
26
The use of aripiprazole in early onset schizophrenia: safety and efficacy. (20527278)
2009
27
Aripiprazole as an adjunct to clozapine therapy in adolescents with early-onset schizophrenia: a retrospective chart review. (19585394)
2009
28
Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia. (19641111)
2009
29
Dichotic listening impairments in early onset schizophrenia are associated with reduced left temporal lobe volume. (19423299)
2009
30
The Maudsley early onset schizophrenia study: cognitive function over a 4-year follow-up period. (18024468)
2008
31
The psychopathological and psychosocial outcome of early-onset schizophrenia: preliminary data of a 13-year follow-up. (18304312)
2008
32
Long-term sustained benefits of clozapine treatment in refractory early onset schizophrenia: a retrospective study in Korean children and adolescents. (18814190)
2008
33
Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. (16920078)
2007
34
Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test. (16309895)
2006
35
Antipsychotics in early onset Schizophrenia: Systematic review and meta-analysis. (16470340)
2006
36
White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. (16113622)
2005
37
Interaction of tumor necrosis alpha - G308A and epidermal growth factor gene polymorphisms in early-onset schizophrenia. (15614591)
2005
38
Risk for early-onset schizophrenia assessed via gray-matter distributions. (16779211)
2005
39
Normal cerebral volume asymmetries in early onset schizophrenia. (14732594)
2004
40
Attenuation of perceptual asymmetries in patients with early-onset schizophrenia: evidence in favour of reduced hemispheric differentiation in schizophrenia? (15382732)
2004
41
Early-onset schizophrenia in children with mental retardation: diagnostic reliability and stability of clinical features. (12544175)
2003
42
Brain volume, asymmetry and intellectual impairment in relation to sex in early-onset schizophrenia. (12893664)
2003
43
Associations between premorbid intellectual performance, early-life exposures and early-onset schizophrenia. Cohort study. (12356656)
2002
44
Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. (11481166)
2001
45
Structural magnetic imaging of the hippocampus in early onset schizophrenia. (11343679)
2001
46
"Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia? (9444905)
1998
47
Liaison between adolescent and adult services in early-onset schizophrenia. (9747420)
1998
48
Is a child's risk of early onset schizophrenia increased in the highest social class? (9075303)
1997
49
A preliminary study on early onset schizophrenia and bipolar disorder: large polyglutamine expansions are not involved. (9335205)
1997
50
A chart review study of late-onset and early-onset schizophrenia. (2574011)
1989

Variations for Early-Onset Schizophrenia

About this section

Expression for genes affiliated with Early-Onset Schizophrenia

About this section
Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for genes affiliated with Early-Onset Schizophrenia

About this section

Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9COMT, MAOA
2
Show member pathways
9.9COMT, MAOA
3
Show member pathways
9.9COMT, MAOA
49.8DRD1, DRD2, DRD4
59.7DRD3, DRD4, HTR2A
69.5DRD1, DRD2, DRD3, DRD4
7
Show member pathways
9.2DRD1, DRD2, DRD3, DRD4, HTR2A
89.1HTR2A, HTR3A, MAOA, SLC6A4
99.0COMT, MAOA, TH
109.0BDNF, SOX10, TH
11
Show member pathways
8.9DRD2, DRD3, DRD4, TH
12
Show member pathways
8.7COMT, DBH, MAOA, TH
13
Show member pathways
8.7COMT, DBH, MAOA, TH
14
Show member pathways
8.7BDNF, DRD1, DRD2, MAOA, TH
15
Show member pathways
8.5BDNF, DRD1, DRD2, DRD3, DRD4, INS
16
Show member pathways
8.1DBH, MAOA, SLC6A4, TH, TNF
17
Show member pathways
7.2BDNF, DNMT3B, DRD1, DRD2, INS, MAOA
187.0BDNF, HTR2A, HTR3A, MAOA, SLC6A4, TH
19
Show member pathways
7.0COMT, DRD1, DRD2, DRD3, DRD4, HTR2A

GO Terms for genes affiliated with Early-Onset Schizophrenia

About this section

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:003477410.3DBH, INS
2axonGO:00304248.6COMT, DRD2, HTR2A, HTR3A, TH
3neuronal cell bodyGO:00430258.4DRD1, DRD4, HTR2A, HTR3A, TH
4integral component of plasma membraneGO:00058878.3DRD1, DRD2, DRD3, DRD4, HTR2A, SLC6A4

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idNameGO IDScoreTop Affiliating Genes
1orbitofrontal cortex developmentGO:002176910.5DRD1, DRD2
2cerebral cortex GABAergic interneuron migrationGO:002185310.5DRD1, DRD2
3negative regulation of circadian sleep/wake cycle, sleepGO:004232110.5DRD1, DRD2
4neurotransmitter catabolic processGO:004213510.5COMT, MAOA
5negative regulation of synaptic transmission, glutamatergicGO:005196710.5DRD2, HTR2A
6negative regulation of dopamine receptor signaling pathwayGO:006016010.4DRD2, DRD3
7acid secretionGO:004671710.4DRD2, DRD3
8regulation of locomotion involved in locomotory behaviorGO:009032510.3DRD2, DRD3
9regulation of cAMP metabolic processGO:003081410.3DRD2, DRD3
10negative regulation of voltage-gated calcium channel activityGO:190138610.3DRD2, DRD4
11synapse assemblyGO:000741610.3BDNF, DRD1, DRD2
12temperature homeostasisGO:000165910.3DRD1, DRD2, HTR2A
13regulation of dopamine uptake involved in synaptic transmissionGO:005158410.2DRD1, DRD2, DRD3
14regulation of dopamine secretionGO:001405910.1DRD2, DRD3, HTR2A
15positive regulation of dopamine uptake involved in synaptic transmissionGO:005158610.1DRD2, DRD4
16fear responseGO:004259610.1DBH, DRD4
17response to morphineGO:004327810.1DRD1, DRD2, DRD3
18dopamine catabolic processGO:004242010.1COMT, DBH, MAOA
19prepulse inhibitionGO:006013410.1DRD1, DRD2, DRD3
20response to histamineGO:003477610.0DRD2, DRD3, DRD4
21negative regulation of adenylate cyclase activityGO:000719410.0DRD2, DRD3, DRD4
22arachidonic acid secretionGO:00504829.9DRD2, DRD3, DRD4
23behavioral response to ethanolGO:00481499.9DBH, DRD2, DRD4
24peristalsisGO:00304329.9DLG1, DRD1, DRD2
25adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00071959.9DRD2, DRD3, DRD4
26norepinephrine biosynthetic processGO:00424219.9DBH, TH
27catecholamine biosynthetic processGO:00424239.9DBH, TH
28visual learningGO:00085429.8DBH, DRD1, DRD2, DRD3
29dopamine receptor signaling pathwayGO:00072129.8DRD1, DRD2, DRD3, DRD4
30cellular response to nicotineGO:00713169.8TH, TNF
31negative regulation of protein secretionGO:00507099.8DRD2, DRD3, DRD4, INS
32response to activityGO:00148239.8DNMT3B, DRD1, TH
33negative regulation of protein kinase B signalingGO:00518989.7DLG1, DRD2, DRD3
34response to nicotineGO:00350949.7DRD1, DRD2, TH
35associative learningGO:00083069.7DBH, DRD1, DRD2
36response to steroid hormoneGO:00485459.5DRD1, DRD4, TH
37behavioral response to cocaineGO:00481489.5DRD1, DRD2, DRD3, DRD4, HTR2A
38response to estradiolGO:00323559.4DNMT3B, DRD1, SLC6A4, TH
39dopamine metabolic processGO:00424179.4COMT, DRD1, DRD2, DRD3, DRD4
40mating behaviorGO:00076179.3DRD1, TH
41response to hypoxiaGO:00016669.3DNMT3B, DRD2, SLC6A4, TH
42response to cocaineGO:00422209.2DNMT3B, DRD1, DRD2, DRD3, HTR3A
43learningGO:00076129.0COMT, DRD1, DRD3, TH
44memoryGO:00076139.0DBH, DRD1, HTR2A, SLC6A4, TH
45response to ethanolGO:00454718.9DRD1, DRD2, DRD3, HTR3A, TH
46locomotory behaviorGO:00076268.9DBH, DRD1, DRD2, DRD3, TH
47synaptic transmission, dopaminergicGO:00019638.7DRD1, DRD2, DRD3, DRD4, TH
48social behaviorGO:00351768.7DRD1, DRD3, DRD4, SLC6A4, TH
49response to drugGO:00424938.2COMT, DNMT3B, DRD1, DRD2, DRD3, HTR2A
50response to amphetamineGO:00019758.0DBH, DRD1, DRD2, DRD3, DRD4, TH

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.1INS, YWHAH
2serotonin bindingGO:005137810.0HTR2A, HTR3A, MAOA
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.7DRD2, DRD3, DRD4
4dopamine neurotransmitter receptor activity, coupled via GsGO:00015889.6DRD1, DRD3, DRD4
5drug bindingGO:00081449.4DRD1, DRD2, DRD3, DRD4, HTR2A
6dopamine neurotransmitter receptor activityGO:00049529.2DRD1, DRD2, DRD3, DRD4
7dopamine bindingGO:00352408.6DRD1, DRD2, DRD3, DRD4, TH

Sources for Early-Onset Schizophrenia

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet