MCID: ERL020
MIFTS: 49

Early-Onset Schizophrenia malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

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Aliases & Descriptions for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 51
 
Early Onset Schizophrenia 65

Classifications:



External Ids:

Orphanet51 96369
UMLS65 C1656427

Summaries for Early-Onset Schizophrenia

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MalaCards based summary: Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to autism spectrum disorder and schizophrenia. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways are Neurotransmitter Clearance In The Synaptic Cleft and Dopamine metabolism. Affiliated tissues include brain, b cells and breast, and related mouse phenotypes are respiratory system and normal.

Related Diseases for Early-Onset Schizophrenia

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Diseases in the Schizophrenia family:

Schizophrenia 17 Schizophrenia 16
Schizophrenia 10 Schizophrenia 4
Schizophrenia 15 early-onset schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1autism spectrum disorder30.4BDNF, HTR2A, SLC6A4
2schizophrenia26.3BDNF, COMT, DBH, DRD1, DRD2, DRD3
3adult brainstem gliosarcoma10.5DRD2, HTR2A
4xerophthalmia10.5HTR2A, SLC6A4
5panuveitis10.4DRD2, HTR2A, NDUFS4
6testicular leydig cell tumor10.4DRD1, DRD2
7conjunctiva squamous cell carcinoma10.4DRD2, HTR2A, NDUFS4
8kluver-bucy syndrome10.4DRD2, HTR2A, SLC6A4
9prostate adenocarcinoma10.3DRD2, HTR2A, SLC6A4
10geniculate herpes zoster10.3DRD2, HTR2A, SLC6A4
11ainhum10.3COMT, DRD2
12ehrlichiosis10.3HTR2A, MAOA
13vogt-koyanagi-harada disease10.3HTR2A, MAOA, SLC6A4
14anal spasm10.3DRD2, HTR2A, SOX10
15tympanosclerosis10.3HTR2A, MAOA, SLC6A4
16brachial plexus neoplasm10.3HTR2A, MAOA, SLC6A4
17ulcer of lower limbs10.2BDNF, COMT, DRD2
18melancholia10.2DRD2, HTR2A, SLC6A4
19intermittent explosive disorder10.2HTR2A, MAOA, SLC6A4
20uterine corpus adenomatoid tumor10.2HTR2A, SLC6A4
21ovarian mixed germ cell neoplasm10.2HTR2A, MAOA, SLC6A4
22hairy cell leukemia10.2HTR2A, MAOA, TNF
23brain ischemia10.2BDNF, COMT, DRD2
24neurodegeneration with optic atrophy, childhood onset10.2COMT, HTR2A, SLC6A4
25upper lip cancer10.2BDNF, HTR2A, TNF
26ring chromosome 14 syndrome10.2COMT, HTR2A, MAOA
27nondystrophic myotonia10.2INS, TNF
28refractive error10.2COMT, DRD2, HTR2A
29atopic dermatitis10.2BDNF, HTR2A, SLC6A4
30wernicke-korsakoff syndrome10.2BDNF, HTR2A, HTR3A
31amusia10.2COMT, DRD2, SLC6A4
32alcoholic hepatitis10.1BDNF, DRD2, HTR2A, SLC6A4
33mitochondrial metabolism disease10.1BDNF, HTR2A, TNF
34periampullary adenoma10.1HTR2A, SLC6A4, TNF
35exostosis10.1HTR2A, SLC6A4
36obstructive sleep apnea10.1HTR2A, SLC6A4, TNF
37bipolar disorder10.1
38lymphadenitis10.1BDNF, HTR2A, MAOA, SLC6A4
39paranoid personality disorder10.1DRD2, DRD4, HTR2A
40cerebritis10.0
41neuronitis10.0
42hereditary myopathy with lactic acidosis due to iscu deficiency10.0HTR3A, MAOA, SLC6A4
43chorioangioma10.0DRD2, DRD4, HTR2A
44viral exanthem10.0BDNF, COMT, DRD2, SLC6A4
45acatalasemia10.0BDNF, COMT, HTR2A, SLC6A4
46adrenal cortical adenoma10.0BDNF, COMT, HTR2A, MAOA
47hallucinogen dependence10.0DRD2, DRD4, MAOA
48obsessive-compulsive personality disorder9.9DRD4, MAOA
49ulcerative blepharitis9.9BDNF, COMT, MAOA, SLC6A4
50deafness and myopia9.9DRD4, HTR2A, MAOA

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to early-onset schizophrenia

Symptoms for Early-Onset Schizophrenia

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Drugs & Therapeutics for Early-Onset Schizophrenia

About this section

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MolindoneapprovedPhase 427416-34-423897
Synonyms:
(+-)-Molindone
(+-)-molindone
15622-65-8 (mono-hydrochloride)
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
65973-37-7
7416-34-4
AB00514709
AC-7052
AC1L2N2H
AC1Q2SRY
AC1Q6J6B
BPBio1_001374
BRD-A65280694-003-03-8
BSPBio_001249
C07230
C16H24N2O2
CHEBI:103799
CHEMBL460
CID23897
D08226
DB01618
HSDB 3131
I14-11948
 
L001248
LS-83891
MOLINDONE
Moban
MolPort-005-940-887
Molindona
Molindona [INN-Spanish]
Molindona [inn-spanish]
Molindone
Molindone (INN)
Molindone (MOL)
Molindone Monohydrochloride
Molindone [INN:BAN]
Molindonum
Molindonum [INN-Latin]
Molindonum [inn-latin]
NCGC00162218-01
NCGC00162218-02
NCGC00162218-03
Oprea1_038890
Prestwick0_001035
Prestwick1_001035
Prestwick2_001035
Prestwick3_001035
SID26755691
SID50111112
SID90341242
SPBio_003100
UNII-RT3Y3QMF8N
2
Olanzapineapproved, investigationalPhase 4379132539-06-14585
Synonyms:
132539-06-1
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10 H -thieno[2,3- b ] [1,5]benzodiazepine
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
AC-665
AC1L1IHS
AKOS000282888
ALKS-7921
BIDD:GT0332
BIDD:PXR0138
Bio-0169
C07322
C076029
C17H20N4S
CHEBI:7735
CHEMBL715
CID4585
CPD000466345
D00454
DB00334
Eli Lilly brand of olanzapine
HMS2051H05
HMS2089M04
HMS2093I04
I06-0784
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H
InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
Jsp001969
KS-1090
L000455
L005958
LS-152313
LY 170053
LY-170052
LY-170053
 
Lanzac
Lilly brand of olanzapine
MLS000759457
MLS001165781
MLS001195646
MLS001424057
Midax
MolPort-002-885-845
MolPort-003-666-569
MolPort-005-977-341
NCGC00096077-01
NCGC00096077-03
NCGC00096077-04
Olansek
Olanzapin
Olanzapina
Olanzapine
Olanzapine (JAN/USAN/INN)
Olanzapine (OLA)
Olanzapine [USAN:INN]
Olanzapine pamoate
Olanzapinum
S2493_Selleck
SAM001246652
SMR000466345
SPECTRUM1505024
STK634338
Symbyax
TL8000772
UNII-N7U69T4SZR
Zalasta
Zydis
Zyprexa
Zyprexa (TN)
Zyprexa Intramuscular
Zyprexa Velotab
Zyprexa Zydis
olanzapina
olanzapine
olanzapinum
3
DopamineapprovedPhase 4, Phase 2308462-31-7, 51-61-6681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine Hcl
Dopamine Hydrochloride
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
 
KBio1_000780
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
4
Risperidoneapproved, investigationalPhase 4477106266-06-25073
Synonyms:
106266-06-2
3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[
3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-[2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
AB00514010
AC-1306
AC1L1JJU
BIDD:GT0262
BRD-K53857191-001-04-5
BRN 4891881
Belivon
Bio-0092
Buspirone
C23H27FN4O2
CAS-106266-06-2
CHEBI:8871
CHEMBL85
CID5073
CPD000466323
Consta, Risperdal
D00426
D018967
DB00734
EU-0101074
HMS1571M19
HMS2051H07
HMS2089C22
HSDB 7580
I01-1156
Jsp000573
KS-1106
L000510
LS-134196
Lopac-R-118
MLS000759429
MLS001165758
MLS001424081
MolPort-002-885-858
NCGC00015883-01
 
NCGC00015883-02
NCGC00015883-03
NCGC00094352-01
NCGC00094352-02
NCGC00094352-03
NCGC00179257-01
Prestwick0_001029
Prestwick1_001029
R 62 766
R 64 766, Risperdal, Risperidone
R 64,766
R 64766
R-118
R-64,766
R-64-766
R-64766
R64,766
R64766
Rispen
Risperdal
Risperdal (TN)
Risperdal Consta
Risperdal M-Tab
Risperdal M-tab
Risperidal
Risperidal M-Tab
Risperidona
Risperidona [Spanish]
Risperidone
Risperidone (JAN/USAN/INN)
Risperidone (RIS)
Risperidone M-tab
Risperidone [USAN:BAN:INN]
Risperidone, placebo
Risperidonum
Risperidonum [Latin]
Risperin
Rispolept
Rispolin
S1615_Selleck
SAM001246595
SMR000466323
SPBio_003078
STK646402
Sequinan
Spiron
TL8000230
UNII-L6UH7ZF8HC
risperdone
risperidone
5
SerotoninPhase 4, Phase 2314750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
6AntiemeticsPhase 43213
7Dopamine AgentsPhase 4, Phase 23084
8Serotonin AntagonistsPhase 4, Phase 21175
9Tranquilizing AgentsPhase 4, Phase 23597
10Serotonin Uptake InhibitorsPhase 41369
11Psychotropic DrugsPhase 4, Phase 25501
12Serotonin AgentsPhase 4, Phase 22668
13Dopamine AntagonistsPhase 4, Phase 2927
14Peripheral Nervous System AgentsPhase 418510
15Gastrointestinal AgentsPhase 46401
16Central Nervous System DepressantsPhase 4, Phase 210016
17Antipsychotic AgentsPhase 4, Phase 22130
18Neurotransmitter Uptake InhibitorsPhase 42857
19Neurotransmitter AgentsPhase 4, Phase 214795
20Immunologic FactorsPhase 318483
21Rho(D) Immune GlobulinPhase 3206
22Immunoglobulins, IntravenousPhase 3211
23AntibodiesPhase 34477
24ImmunoglobulinsPhase 34477
25Gamma-GlobulinsPhase 322
26
ZiprasidoneapprovedPhase 2140146939-27-760854
Synonyms:
138982-67-9 (hydrochloride monohydrate)
146939-27-7
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
6-chloro-5-[2-[4-(7-thia-8-azabicyclo[4.3.0]nona-1,3,5,8-tetraen-9-yl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one
AC1L1U27
Ambap122883-93-6
BIDD:GT0042
C07568
C21H21ClN4OS
CHEBI:10119
CHEMBL708
CID60854
CP 88059
CP 88059-01
CP-88,059
CP-88,059-01
CP-88,059-1
CP-88059-1
CPD000466328
D08687
DB00246
 
Geodon
Geodon Oral
I14-0766
L000659
LS-83744
MLS000759435
MolPort-003-850-885
SAM001246607
SMR000466328
TL8000889
UNII-6UKA5VEJ6X
Zeldox
Zipradon
Zipradon (TN)
Ziprasidona
Ziprasidone
Ziprasidone (INN)
Ziprasidone Hydrochloride
Ziprasidone [INN:BAN]
Ziprasidone hydrochloride
Ziprasidone mesylate trihydrate
Ziprasidonum
ziprasidona
ziprasidonum
ziprazidone
27Contraceptives, OralPhase 23734
28
Aripiprazoleapproved, investigational342129722-12-960795
Synonyms:
129722-12-9
24-29-3
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril
7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
AC-1554
AC1L1TXZ
AC1Q3T38
ALKS-9070
Abilify
Abilify (TN)
Abilify DISCMELT
Abilify Discmelt
Abilify Maintena
Abilitat
Aripiprazol
Aripiprazole
Aripiprazole (JAN/USAN/INN)
Aripiprazole [USAN]
Aripiprazolum
Aripirazole
Arpizol
Asprito|
BMS-337039
Bio-0004
Bristol-Myers Squibb brand of aripiprazole
C094645
C12564
C23H27Cl2N3O2
CHEBI:31236
CHEMBL1112
CID60795
 
CPD000466383
D01164
DB01238
Discmelt
FT-0082572
HMS2051I18
HMS2089M20
HMS2093F22
HSDB 7320
KS-1030
L001339
LS-142666
MLS000759517
MLS001165779
MLS001195621
MLS001424078
MolPort-002-885-808
MolPort-003-844-657
NCGC00159510-02
NCGC00159510-03
OPC 31
OPC-14597
OPC-31
Opc 14597
Otsuka brand of aripiprazole
Pripiprazole
S06-0010
SAM001246750
SMR000466383
STK625160
TL8000707
TL80090184
UNII-82VFR53I78
aripiprazol
aripiprazole
aripiprazolum
||OPC 14597

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS)CompletedNCT00053703Phase 4
2Efficacy Study of Early Onset of Antipsychotic Drug Action in SchizophreniaCompletedNCT00337662Phase 4
3Treatment With Risperidone Long Acting Injectable (RLAI) in an Early Phase of PsychosisCompletedNCT00369239Phase 4
45-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset SchizophreniaRecruitingNCT02435654Phase 4
5Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
6Ziprasidone in Early Onset Schizophrenia Spectrum DisordersCompletedNCT01006551Phase 2
7Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset PsychosisRecruitingNCT00465920Phase 2
8Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic DisordersNot yet recruitingNCT02097563Phase 2
9Cognitive Remediation Therapy (CRT) in Adolescents With EOSCompletedNCT01701609
10Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission SchizophreniaCompletedNCT01781364
11Intensive Computerized Brain Training (ICBT) in Youth With Early Onset Psychosis (EOP)CompletedNCT01027962
12Sex Differences in Early Brain Development; Brain Development in Turner SyndromeCompletedNCT00877942
13Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS)RecruitingNCT02764164
14Evaluating Genetic Risk Factors for Childhood-Onset SchizophreniaRecruitingNCT00001198
15Aripiprazole Treatment of the ProdromeTerminatedNCT00169949

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

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Anatomical Context for Early-Onset Schizophrenia

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MalaCards organs/tissues related to Early-Onset Schizophrenia:

33
Brain, B cells, Breast, Lung, Prostate, Monocytes, Bone

Animal Models for Early-Onset Schizophrenia or affiliated genes

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MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8BDNF, COMT, DRD1, DRD2, NDUFS4, SOX10
2MP:00028738.6BDNF, DBH, DRD1, DRD2, INS, NDUFS4
3MP:00053758.4DBH, DRD1, DRD2, DRD3, INS, TNF
4MP:00053918.3BDNF, DBH, DNMT3B, DRD1, DRD4, INS
5MP:00053818.2BDNF, DRD1, DRD2, DRD3, HTR2A, INS
6MP:00053697.7DRD1, DRD2, HTR2A, HTR3A, INS, NDUFS4
7MP:00107717.4BDNF, DBH, DRD1, DRD2, HTR3A, INS
8MP:00053797.0BDNF, COMT, DBH, DNMT3B, DRD2, HTR2A
9MP:00053856.7COMT, DBH, DNMT3B, DRD1, DRD2, DRD3
10MP:00107686.0BDNF, DBH, DNMT3B, DRD1, DRD2, DRD3
11MP:00053785.8BDNF, DBH, DNMT3B, DRD1, DRD2, DRD3
12MP:00053765.2BDNF, COMT, DBH, DRD1, DRD2, DRD3
13MP:00053865.1BDNF, COMT, DBH, DRD1, DRD2, DRD3
14MP:00036315.1BDNF, COMT, DBH, DNMT3B, DRD1, DRD2

Publications for Early-Onset Schizophrenia

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Articles related to Early-Onset Schizophrenia:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Altered expression of mRNA profiles in blood of early-onset schizophrenia. (26733343)
2016
2
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. (26916502)
2016
3
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. (25779033)
2015
4
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. (26440542)
2015
5
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. (26001923)
2015
6
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. (25999041)
2015
7
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. (26484249)
2015
8
Different and Shared Brain Volume Abnormalities in Late- and Early-Onset Schizophrenia. (25358262)
2014
9
Homotopic connectivity in drug-naA^ve, first-episode, early-onset schizophrenia. (25130214)
2014
10
White matter abnormalities and cognitive impairment in early-onset schizophrenia-spectrum disorders. (24565363)
2014
11
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
12
Aberrant default mode functional connectivity in early onset schizophrenia. (23923052)
2013
13
Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings. (24012081)
2013
14
Changes in the diagnosed incidence of early onset schizophrenia over four decades. (22906158)
2013
15
Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia. (22354179)
2012
16
A meta-analysis of neuropsychological functioning in patients with early onset schizophrenia and pediatric bipolar disorder. (21391023)
2011
17
Neuronal basis of haedonic appraisal in early onset schizophrenia: FMRI investigation. (24059618)
2011
18
Brain functional connectivity of functional magnetic resonance imaging of patients with early-onset schizophrenia. (20130360)
2010
19
Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia. (19894076)
2010
20
Antipsychotic treatment of first-episode or early-onset schizophrenia. (19635232)
2009
21
The use of aripiprazole in early onset schizophrenia: safety and efficacy. (20527278)
2009
22
Aripiprazole as an adjunct to clozapine therapy in adolescents with early-onset schizophrenia: a retrospective chart review. (19585394)
2009
23
Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study. (18759640)
2008
24
A diffusion tensor imaging study of white matter in early-onset schizophrenia. (17662964)
2008
25
Metabolic side effects of risperidone in children and adolescents with early-onset schizophrenia. (19287568)
2008
26
Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. (18794207)
2008
27
Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders. (18533765)
2008
28
The Maudsley early onset schizophrenia study. Predictors of psychosocial outcome at 4-year follow-up. (17896122)
2007
29
Pathophysiology of early onset schizophrenia. (17671865)
2007
30
Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. (16920078)
2007
31
Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test. (16309895)
2006
32
Lateralized deficit of response inhibition in early-onset schizophrenia. (16336744)
2006
33
Antipsychotics in early onset Schizophrenia: Systematic review and meta-analysis. (16470340)
2006
34
White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. (16113622)
2005
35
Early-onset schizophrenia: a 15-year follow-up. (16220219)
2005
36
Normal cerebral volume asymmetries in early onset schizophrenia. (14732594)
2004
37
The Maudsley early onset schizophrenia study: cognitive function in adolescents with recent onset schizophrenia. (12729865)
2003
38
Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry. (11793166)
2002
39
Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. (11481166)
2001
40
Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. (11378311)
2001
41
Structural magnetic imaging of the hippocampus in early onset schizophrenia. (11343679)
2001
42
Cognitive functions and psychopathological symptoms in early-onset schizophrenia. (10795851)
2000
43
Blood biogenic amines during clozapine treatment of early-onset schizophrenia. (9503259)
1997
44
Is a child's risk of early onset schizophrenia increased in the highest social class? (9075303)
1997
45
A preliminary study on early onset schizophrenia and bipolar disorder: large polyglutamine expansions are not involved. (9335205)
1997
46
Predicting outcome in child and adolescent (early onset) schizophrenia and bipolar disorder. (1537767)
1992
47
Expressed emotion and early onset schizophrenia: a one year follow-up. (1946856)
1991
48
A chart review study of late-onset and early-onset schizophrenia. (2574011)
1989
49
Developmental arrest of cerebral asymmetries in early onset schizophrenia. (2608767)
1989
50
Reduced activity of angiotensin-converting enzyme in basal ganglia in early onset schizophrenia. (6247736)
1980

Variations for Early-Onset Schizophrenia

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Expression for genes affiliated with Early-Onset Schizophrenia

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Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for genes affiliated with Early-Onset Schizophrenia

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Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7COMT, MAOA
29.7COMT, MAOA
3
Show member pathways
9.7COMT, MAOA
4
Show member pathways
9.7COMT, MAOA
59.4DRD1, DRD2, DRD4
6
Show member pathways
9.4BDNF, DRD1, DRD2, MAOA
7
Show member pathways
9.3COMT, DBH, MAOA
8
Show member pathways
9.3COMT, DBH, MAOA
99.1DRD3, DRD4, HTR2A
10
Show member pathways
9.0DRD2, DRD3, DRD4
11
Show member pathways
9.0DBH, MAOA, SLC6A4, TNF
128.8DRD1, DRD2, DRD3, DRD4
138.7HTR2A, HTR3A, MAOA, SLC6A4
14
Show member pathways
8.5DRD1, DRD2, DRD3, DRD4, HTR2A
15
Show member pathways
7.8BDNF, DRD1, DRD2, DRD3, DRD4, INS
167.6BDNF, HTR2A, HTR3A, MAOA, SLC6A4, TNF
17
Show member pathways
6.6COMT, DRD1, DRD2, DRD3, DRD4, HTR2A

GO Terms for genes affiliated with Early-Onset Schizophrenia

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Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304258.8COMT, DRD1, DRD2, DRD4, HTR2A

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:004582110.6HTR2A, INS
2negative regulation of lipid catabolic processGO:005099510.5INS, TNF
3peristalsisGO:003043210.3DRD1, DRD2
4neurotransmitter catabolic processGO:004213510.3COMT, MAOA
5neurotransmitter biosynthetic processGO:004213610.3COMT, MAOA
6response to nicotineGO:003509410.3DRD1, DRD2
7phospholipase C-activating dopamine receptor signaling pathwayGO:006015810.3DRD1, DRD2
8positive regulation of neuroblast proliferationGO:000205210.3DRD2, SOX10
9dopamine receptor signaling pathwayGO:000721210.3DRD1, DRD2
10regulation of long-term neuronal synaptic plasticityGO:004816910.2DRD1, DRD2
11modulation of synaptic transmissionGO:005080410.2DRD2, DRD4
12positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:005148210.2DRD1, DRD2
13negative regulation of voltage-gated calcium channel activityGO:190138610.2DRD2, DRD4
14regulation of protein secretionGO:005070810.2INS, TNF
15dopamine catabolic processGO:004242010.2COMT, DBH
16positive regulation of mitotic nuclear divisionGO:004584010.2DRD3, INS
17grooming behaviorGO:000762510.2DRD1, DRD2
18G-protein coupled receptor internalizationGO:000203110.1DRD2, DRD3
19regulation of cAMP metabolic processGO:003081410.1DRD2, DRD3
20acid secretionGO:004671710.1DRD2, DRD3
21regulation of locomotion involved in locomotory behaviorGO:009032510.1DRD2, DRD3
22positive regulation of cytokinesisGO:003246710.1DRD2, DRD3
23regulation of sodium ion transportGO:000202810.1DRD2, YWHAH
24regulation of dopamine secretionGO:001405910.1DRD2, DRD3
25negative regulation of adenylate cyclase activityGO:000719410.1DRD2, DRD3
26positive regulation of renal sodium excretionGO:003581510.0DRD2, DRD3
27negative regulation of circadian sleep/wake cycle, sleepGO:004232110.0DRD1, DRD2
28response to histamineGO:00347769.9DRD3, DRD4
29maternal behaviorGO:00427119.9DBH, DRD1
30temperature homeostasisGO:00016599.9DRD1, DRD2, HTR2A
31adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.8DRD1, DRD3
32prepulse inhibitionGO:00601349.7DRD1, DRD2, DRD3
33orbitofrontal cortex developmentGO:00217699.7DRD1, DRD2
34visual learningGO:00085429.7DRD1, DRD2, DRD3
35synaptic transmission, dopaminergicGO:00019639.6DRD1, DRD2, DRD3
36negative regulation of protein secretionGO:00507099.6DRD3, DRD4, INS
37memoryGO:00076139.5DBH, DRD1, HTR2A, SLC6A4
38dopamine metabolic processGO:00424179.5COMT, DRD3, DRD4
39associative learningGO:00083069.5DRD1, DRD2, DRD4
40response to morphineGO:00432789.5DRD1, DRD2, DRD3
41learningGO:00076129.4COMT, DRD1, DRD3
42social behaviorGO:00351769.4DRD1, DRD3, DRD4
43regulation of dopamine uptake involved in synaptic transmissionGO:00515849.2DRD1, DRD2, DRD3
44G-protein coupled receptor signaling pathwayGO:00071869.2DRD1, DRD2, DRD3, HTR2A, INS
45response to amphetamineGO:00019758.7DBH, DRD1, DRD2, DRD3, DRD4
46behavioral response to cocaineGO:00481488.5DRD1, DRD2, DRD3, DRD4, HTR2A
47response to drugGO:00424938.5COMT, DNMT3B, DRD1, DRD2, DRD3, HTR2A

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.8DRD1, DRD2, DRD3, DRD4, HTR3A, SLC6A4

Sources for Early-Onset Schizophrenia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet