MCID: EST003
MIFTS: 41

Eastern Equine Encephalitis

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Eastern Equine Encephalitis

MalaCards integrated aliases for Eastern Equine Encephalitis:

Name: Eastern Equine Encephalitis 12 49 55 3 14
Eee 12 49 3
Encephalomyelitis, Eastern Equine 41 69
Neuroinvasive Eastern Equine Encephalitis Virus Infection 12
Eastern Equine Encephalomyelitis 55

Characteristics:

Orphanet epidemiological data:

55
eastern equine encephalitis
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:10841
ICD10 32 A83.2
ICD9CM 34 062.2
MeSH 41 D020242
Orphanet 55 ORPHA83594
UMLS via Orphanet 70 C0153065
ICD10 via Orphanet 33 A83.2
UMLS 69 C0153065

Summaries for Eastern Equine Encephalitis

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 83594Disease definitionEastern equine encephalitis (EEE) is an acute arboviral infection caused by an alphavirus of the Togaviridae family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality.Visit the Orphanet disease page for more resources. Last updated: 2/10/2014

MalaCards based summary : Eastern Equine Encephalitis, also known as eee, is related to western equine encephalitis and encephalitis, and has symptoms including sudden onset of headache, high fever and chills. An important gene associated with Eastern Equine Encephalitis is XYLT1 (Xylosyltransferase 1), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include brain of horses, brain and testes.

CDC : 3 Image of Culiseta melanura mosquito, photo taken by Jason Williams, reproduced by permission from the Virginia Mosquito Control Association.

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in brain of horses and humans, has material basis in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has symptom sudden onset of headache, has symptom high fever, has symptom chills, has symptom vomiting, has symptom disorientation, has symptom seizures, and has symptom coma.

Wikipedia : 72 Eastern equine encephalitis (EEE), commonly called Triple E or, sleeping sickness (not to be confused... more...

Related Diseases for Eastern Equine Encephalitis

Diseases related to Eastern Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 western equine encephalitis 11.6
2 encephalitis 11.0
3 st. louis encephalitis 10.2
4 west nile virus 10.1
5 venezuelan equine encephalitis 10.1
6 blood group, i system 10.0
7 polyarteritis nodosa, childhood-onset 9.9
8 multiple mitochondrial dysfunctions syndrome 5 9.9
9 hemophagocytic lymphohistiocytosis 9.9
10 rabies 9.9
11 newcastle disease 9.9
12 stomatitis 9.9
13 angioid streaks 9.7 XYLT1 XYLT2
14 sotos syndrome 1 9.6 DPH1 XYLT2
15 pseudoxanthoma elasticum 9.5 XYLT1 XYLT2

Graphical network of the top 20 diseases related to Eastern Equine Encephalitis:



Diseases related to Eastern Equine Encephalitis

Symptoms & Phenotypes for Eastern Equine Encephalitis

Symptoms:

12
  • sudden onset of headache
  • high fever
  • chills
  • vomiting
  • disorientation
  • seizures
  • coma

Drugs & Therapeutics for Eastern Equine Encephalitis

Drugs for Eastern Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity Study of Eastern Equine Encephalitis (EEE) Vaccine Active, not recruiting NCT00584805 Phase 2
2 Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine, Inactivated, Dried, TSI-GSD 104, Lot 2-1-89, in Healthy Adult Subjects at Risk of Exposure to Eastern Equine Encephalitis Virus Enrolling by invitation NCT02654509 Phase 2

Search NIH Clinical Center for Eastern Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, eastern equine

Genetic Tests for Eastern Equine Encephalitis

Anatomical Context for Eastern Equine Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Eastern Equine Encephalitis:

18
Brain Of Horses

MalaCards organs/tissues related to Eastern Equine Encephalitis:

38
Brain, Testes, B Cells, Salivary Gland, Kidney

Publications for Eastern Equine Encephalitis

Articles related to Eastern Equine Encephalitis:

(show top 50) (show all 242)
# Title Authors Year
1
Eastern equine encephalitis. ( 28754695 )
2017
2
Wetland characteristics linked to broad-scale patterns in Culiseta melanura abundance and eastern equine encephalitis virus infection. ( 29047412 )
2017
3
Characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (Callithrix jacchus). ( 28173871 )
2017
4
Seasonal Patterns in Eastern Equine Encephalitis Virus Antibody in Songbirds in Southern Maine. ( 28287934 )
2017
5
Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly. ( 28468889 )
2017
6
Fatal Eastern Equine Encephalitis in a Patient on Maintenance Rituximab: A Case Report. ( 28480291 )
2017
7
Geography and Timing of Cases of Eastern Equine Encephalitis in New York State from 1992 to 2012. ( 26901637 )
2016
8
MRI findings in eastern equine encephalitis: the "parenthesis" sign. ( 26995574 )
2016
9
Case of eastern equine encephalitis presenting in winter. ( 27165999 )
2016
10
Rabies direct fluorescent antibody test does not inactivate rabies or eastern equine encephalitis viruses. ( 27079827 )
2016
11
Characterizing areas of potential human exposure to eastern equine encephalitis virus using serological and clinical data from horses. ( 27903326 )
2016
12
Locally Acquired Eastern Equine Encephalitis Virus Disease, Arkansas, USA. ( 27662563 )
2016
13
Host associations of mosquitoes at eastern equine encephalitis virus foci in Connecticut, USA. ( 27577939 )
2016
14
Eastern Equine Encephalitis Treated With Intravenous Immunoglobulins. ( 26740855 )
2016
15
Dynamics of Vector-Host Interactions in Avian Communities in Four Eastern Equine Encephalitis Virus Foci in the Northeastern U.S. ( 26751704 )
2016
16
Vector Competence and Capacity of Culex erraticus (Diptera: Culicidae) for Eastern Equine Encephalitis Virus in the Southeastern United States. ( 26659606 )
2016
17
Widespread Detection of Antibodies to Eastern Equine Encephalitis, West Nile, St. Louis Encephalitis, and Turlock Viruses in Various Species of Wild Birds from Across the United States. ( 27162269 )
2016
18
Antibody and Viral Nucleic Acid Testing of Serum and Cerebrospinal Fluid for Diagnosis of Eastern Equine Encephalitis. ( 26063852 )
2015
19
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. ( 25908124 )
2015
20
Production of a Sindbis/Eastern Equine Encephalitis chimeric virus inactivated cell culture antigen. ( 26205552 )
2015
21
Serum creatine kinase changes in Eastern equine encephalitis. ( 26463757 )
2015
22
Eastern equine encephalitis virus in mice I: clinical course and outcome are dependent on route of exposure. ( 26420265 )
2015
23
Prevalence of eastern equine encephalitis virus antibodies among white-tailed deer populations in maine. ( 25793477 )
2015
24
Mapping eastern equine encephalitis virus risk for white-tailed deer in Michigan. ( 26494931 )
2015
25
Vector-Host Interactions of Culiseta melanura in a Focus of Eastern Equine Encephalitis Virus Activity in Southeastern Virginia. ( 26327226 )
2015
26
Eastern equine encephalitis incubation time periods of 5 and 8 days. ( 25760571 )
2015
27
Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure. ( 26423229 )
2015
28
Insights into the recent emergence and expansion of eastern equine encephalitis virus in a new focus in the Northern New England USA. ( 26453283 )
2015
29
The first outbreak of eastern equine encephalitis in Vermont: outbreak description and phylogenetic relationships of the virus isolate. ( 26043136 )
2015
30
Liposome-antigen-nucleic Acid complexes protect mice from lethal challenge with Western and eastern equine encephalitis viruses. ( 24257615 )
2014
31
A risk index model for predicting eastern equine encephalitis virus transmission to horses in Florida. ( 24764607 )
2014
32
Second generation inactivated eastern equine encephalitis virus vaccine candidates protect mice against a lethal aerosol challenge. ( 25116127 )
2014
33
Detection of Eastern Equine Encephalitis Virus Antibodies in Moose (Alces americana), Maine, 2010. ( 24359417 )
2014
34
Eastern equine encephalitis cases among horses in Brazil between 2005 and 2009. ( 24862186 )
2014
35
CpG/Poly (I:C) mixed adjuvant priming enhances the immunogenicity of a DNA vaccine against eastern equine encephalitis virus in mice. ( 24440303 )
2014
36
B-93The Neuropsychological Sequelae of Eastern Equine Encephalitis Virus in Childhood. ( 25176843 )
2014
37
MRI and encephalography in fatal eastern equine encephalitis. ( 25313378 )
2014
38
Eastern equine encephalitis: a classical case. ( 25675592 )
2014
39
Field investigations of winter transmission of eastern equine encephalitis virus in Florida. ( 25070997 )
2014
40
Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses? ( 25073901 )
2014
41
Vector-host interactions and epizootiology of eastern equine encephalitis virus in Massachusetts. ( 23473221 )
2013
42
Eastern equine encephalitis in children, Massachusetts and New Hampshire,USA, 1970-2010. ( 23343480 )
2013
43
Quadraplex qRT-PCR assay for the simultaneous detection of Eastern equine encephalitis virus and West Nile virus. ( 23891222 )
2013
44
Successful management of severe neuroinvasive eastern equine encephalitis. ( 23733173 )
2013
45
A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus. ( 23333212 )
2013
46
Analysis of murine B-cell epitopes on Eastern equine encephalitis virus glycoprotein E2. ( 23512478 )
2013
47
Comprehensive mapping of common immunodominant epitopes in the eastern equine encephalitis virus E2 protein recognized by avian antibody responses. ( 23922704 )
2013
48
Eastern equine encephalitis virus: high seroprevalence in horses from Southern Quebec, Canada, 2012. ( 23919607 )
2013
49
An epizootic of eastern equine encephalitis virus, Maine, USA in 2009: outbreak description and entomological studies. ( 23208877 )
2013
50
Mosquito bites and eastern equine encephalitis. ( 23970186 )
2013

Variations for Eastern Equine Encephalitis

Expression for Eastern Equine Encephalitis

Search GEO for disease gene expression data for Eastern Equine Encephalitis.

Pathways for Eastern Equine Encephalitis

Pathways related to Eastern Equine Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 XYLT1 XYLT2

GO Terms for Eastern Equine Encephalitis

Biological processes related to Eastern Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.26 XYLT1 XYLT2
2 glycosaminoglycan metabolic process GO:0030203 9.16 XYLT1 XYLT2
3 chondroitin sulfate biosynthetic process GO:0030206 8.96 XYLT1 XYLT2
4 heparan sulfate proteoglycan biosynthetic process GO:0015012 8.62 XYLT1 XYLT2

Molecular functions related to Eastern Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.33 GYG1 XYLT1 XYLT2
2 acetylglucosaminyltransferase activity GO:0008375 8.96 XYLT1 XYLT2
3 protein xylosyltransferase activity GO:0030158 8.62 XYLT1 XYLT2

Sources for Eastern Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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