MCID: ETN001
MIFTS: 57

Eating Disorder malady

Mental diseases, Fetal diseases categories
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Summaries for Eating Disorder

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MedlinePlus:33 Eating disorders are serious behavior problems. they can include severe overeating or not consuming enough food to stay healthy. they also involve extreme concern about your shape or weight. types of eating disorders include anorexia nervosa, in which you become too thin, but you don't eat enough because you think you are fat bulimia nervosa, which involves periods of overeating followed by purging, sometimes through self-induced vomiting or using laxatives binge-eating, which is out-of-control eating women are more likely than men to have eating disorders. they usually start in the teenage years and often occur along with depression, anxiety disorders, and substance abuse. eating disorders can lead to heart and kidney problems and even death. getting help early is important. treatment involves monitoring, talk therapy, nutritional counseling, and sometimes medicines. nih: national institute of mental health

MalaCards based summary: Eating Disorder, also known as eating disorders, is related to bulimia nervosa and morbid obesity. An important gene associated with Eating Disorder is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Adenylate cyclase activating neuropeptides and Syndecan-3-mediated signaling events. The drugs paroxetine and sertraline and the compounds decanoic acid and pramlintide have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:8 A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health.

Wikipedia:65 Eating disorders are psychological illnesses defined by abnormal eating habits that may involve either... more...

Aliases & Classifications for Eating Disorder

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Eating Disorder, Aliases & Descriptions:

Name: Eating Disorder 8 10
 
Eating Disorders 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:8670
MeSH34 D001068
ICD9CM27 307.50
ICD1025 F50, F50.9

Related Diseases for Eating Disorder

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Diseases related to Eating Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1bulimia nervosa31.7MC4R, CCK, GHRL
2morbid obesity31.0GHRL, MC4R
3anorexia nervosa30.7HCRT, MC4R, CCK, GHRL, AGRP
4dyspepsia30.7GHRL, CCK
5obesity30.6AGRP, GHRL, CCK, FAAH, MC4R, HCRT
6panic disorder30.6NPPC, CCK
7drug addiction30.5HCRT
8diabetes mellitus30.5GHRL, CCK, MC4R
9narcolepsy30.5HCRTR1, HCRT
10celiac disease30.4CCK, GHRL
11sleep disorder30.3HCRTR1, HCRT
12double outlet right ventricle30.3GHRL, CCK, MC4R
13type 2 diabetes mellitus30.2GHRL, CCK, MC4R
14schizophrenia30.0HCRT, FAAH, CCK
15alzheimer's disease29.4HCRT, FAAH, CCK, NTF4
16personality disorder10.6
17alexithymia10.5
18body dysmorphic disorder10.5
19obsessive-compulsive disorder10.4
20cannabis dependence10.4FAAH
21amenorrhea10.4
22gastroparesis10.3CCK, GHRL
23glucagonoma10.3CCK, GHRL
24gastrointestinal system disease10.3GHRL, CCK
25obsessive-compulsive personality disorder10.3
26hyperinsulinism10.3GHRL, MC4R
27thyroid medullary carcinoma10.3GHRL, CCK
28acromegaly10.3CCK, GHRL
29attention deficit hyperactivity disorder10.3
30agoraphobia10.3
31borderline personality disorder10.3
32gastric dilatation10.3
33glucose intolerance10.3GHRL, MC4R
34neuroendocrine tumor10.2GHRL, CCK
35alcohol abuse10.2
36bipolar disorder10.2
37osteoporosis10.2
38pathological gambling10.2
39superior mesenteric artery syndrome10.2
40anxiety disorder10.2
41mood disorder10.2
42pancreatitis10.2
43fibromyalgia10.2
44blindness10.2
45pain agnosia10.2FAAH, CCK
46gastritis10.2GHRL, CCK
47carcinoid syndrome10.2GHRL, CCK
48adrenal cortical adenoma10.2HCRTR1, HCRT
49major depressive disorder10.1
50type 1 diabetes mellitus10.1

Graphical network of the top 20 diseases related to Eating Disorder:



Diseases related to eating disorder

Symptoms for Eating Disorder

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Drugs & Therapeutics for Eating Disorder

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Drug clinical trials:

Search ClinicalTrials for Eating Disorder

Search NIH Clinical Center for Eating Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Eating Disorder

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Anatomical Context for Eating Disorder

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MalaCards organs/tissues related to Eating Disorder:

32
Heart, Kidney, Testes, Bone, Brain, Liver, Thyroid, Breast, Ovary

Animal Models for Eating Disorder or affiliated genes

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MGI Mouse Phenotypes related to Eating Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.0MC4R, FEV, FAAH, CCK, GHRL, NPPC
2MP:00053866.3HCRT, HCRTR1, MC4R, FEV, FAAH, NTF4
3MP:00036316.0AGRP, HCRT, HCRTR1, MC4R, FEV, FAAH

Publications for Eating Disorder

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Articles related to Eating Disorder:

(show top 50)    (show all 787)
idTitleAuthorsYear
1
Loss of Control over Eating: A Description of the Eating Disorder/Obesity Spectrum in Women. (24338827)
2014
2
The self-rating of the effects of alcohol questionnaire predicts heavy episodic drinking in a high-risk eating disorder population. (25359121)
2014
3
Central coherence in adolescents with bulimia nervosa spectrum eating disorders. (25146149)
2014
4
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
5
Weight bias internalization, depression, and self-Reported health among overweight binge eating disorder patients. (24039219)
2013
6
Changes in depression and quality of life in obese individuals with binge eating disorder: bariatric surgery versus lifestyle modification. (23260806)
2013
7
The MOSAIC study - comparison of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified, anorexia nervosa type: study protocol for a randomized controlled trial. (23721562)
2013
8
Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. (23377749)
2013
9
Parents' experiences of having and caring for a child with an eating disorder. (24044596)
2013
10
Health-related quality of life in obese presurgery patients with and without binge eating disorder, and subdiagnostic binge eating disorders. (23577241)
2013
11
Eating disorder prevention: current evidence-base and future directions. (23658095)
2013
12
Psychometric evaluation of the eating disorder examination adapted for children. (23456853)
2013
13
Dietary intake in population-based adolescents: support for a relationship between eating disorder symptoms, low fatty acid intake and depressive symptoms. (23216519)
2013
14
An examination of food addiction in a racially diverse sample of obese patients with binge eating disorder in primary care settings. (23332551)
2013
15
Personal meaning and eating disorder treatment: comment on Warren et al. (23895285)
2013
16
An exploration of the perceptions and experiences of living with chronic Anorexia Nervosa (cAN) whilst an Inpatient on an Eating Disorders Unit (EDU): An Interpretative Phenomenological Analysis (IPA) Study. (23933950)
2013
17
The use of multiple methods of compensatory behaviors as an indicator of eating disorder severity in treatment-seeking youth. (22331840)
2012
18
Navigating the transition from pediatric to adult eating disorder programs: perspectives of service providers. (22431280)
2012
19
Body-related social comparison and disordered eating among adolescent females with an eating disorder, depressive disorder, and healthy controls. (23112914)
2012
20
Eating disorder detection through personality traits and self-concept. (23221394)
2012
21
Sleep disturbances and binge eating disorder symptoms during and after pregnancy. (23024439)
2012
22
Active Reward Processing during Human Sleep: Insights from Sleep-Related Eating Disorder. (23205019)
2012
23
The impact of age and BMI on Eating Disorder Examination Questionnaire (EDE-Q) scores in a community sample. (22365803)
2012
24
Significance of overvaluation of shape and weight in an ethnically diverse sample of obese patients with binge-eating disorder in primary care settings. (22449893)
2012
25
Effect of a dissonance-based prevention program on risk for eating disorder onset in the context of eating disorder risk factors. (21975593)
2012
26
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. (22911880)
2012
27
An experimental exploration of behavioral and cognitive-emotional aspects of intolerance of uncertainty in eating disorder patients. (21555203)
2011
28
A comparative analysis of Type 2 diabetes and binge eating disorder in a bariatric sample. (21741014)
2011
29
Stability of eating disorder diagnostic classifications in adolescents: five-year longitudinal findings from a population-based study. (22352971)
2011
30
Parental eating disorder symptoms and observations of mealtime interactions with children. (21414457)
2011
31
Mortality 6 years after inpatient treatment of female Japanese patients with eating disorders associated with alcoholism. (21545673)
2011
32
The STRATOB study: design of a randomized controlled clinical trial of Cognitive Behavioral Therapy and Brief Strategic Therapy with telecare in patients with obesity and binge-eating disorder referred to residential nutritional rehabilitation. (21554734)
2011
33
The relationship between alexithymia and maladaptive perfectionism in eating disorders: a mediation moderation analysis methodology. (22290034)
2011
34
Gastric adenocarcinoma mistakenly diagnosed as an eating disorder: case report. (19365820)
2010
35
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
36
Lack of association between polymorphisms in cannabinoid receptor gene (CNR1) and fatty acid amide hydroxylase gene (FAAH) and eating disorders in a preliminary study. (19801960)
2009
37
Validity of the Eating Disorders Examination-Questionnaire when used with adolescents with bulimia nervosa and atypical bulimia nervosa. (20179414)
2009
38
Low serum BDNF and food intake regulation: a possible new explanation of the pathophysiology of eating disorders. (19152823)
2009
39
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
40
Cannabinoids in eating disorders and obesity. (17952656)
2007
41
Gastrointestinal disturbances in eating disorders: clinical and neurobiological aspects. (16962383)
2006
42
Emerging drugs for eating disorder treatment. (16634704)
2006
43
Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. (16131812)
2005
44
Subclinical eating disorder, polycystic ovary syndrome- is there any connection between these two conditions through leptin- a twin study. (16570705)
2005
45
DPP IV, immune parameters, and psychometrical variables in patients with eating disorders. (12675253)
2003
46
Serum leptin level and restrained eating: study with the Eating Disorder Examination. (11890967)
2002
47
Insulin-like growth factor 1 (IGF-1), a nutritional marker in patients with eating disorders. (11407872)
2001
48
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
49
Aspects of the neuroendocrine control of somatotropic function in calorically restricted dogs and patients with eating disorders: studies with cholinergic drugs. (8739115)
1996
50
Hormonal circadian rhythms in eating disorders. (2334743)
1990

Variations for Eating Disorder

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Expression for genes affiliated with Eating Disorder

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Expression patterns in normal tissues for genes affiliated with Eating Disorder

Search GEO for disease gene expression data for Eating Disorder.

Pathways for genes affiliated with Eating Disorder

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Compounds for genes affiliated with Eating Disorder

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Compounds related to Eating Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1decanoic acid44 28 1112.2GHRL, CCK
2pramlintide44 1111.1CCK, GHRL
3intralipid4410.0CCK, GHRL
4pirenzepine44 28 1112.0CCK, GHRL
5enterostatin449.9HCRT, CCK
6npff449.9HCRT, CCK
7gamma-hydroxybutyrate449.9GHRL, HCRT
8l-nmma449.8NPPC, GHRL, CCK
9atropine44 28 1111.8NPPC, GHRL, CCK
10tetrapeptide449.8MC4R, CCK, NPPC
11octadecaneuropeptide449.7GHRL, CCK, HCRT
12orlistat44 61 1111.7CCK, GHRL
13ether44 5010.7FAAH, GHRL
14olanzapine44 50 28 24 1113.7MC4R, FAAH, GHRL
15c-peptide449.7GHRL, CCK, HCRT
16clozapine44 28 50 1112.7MC4R, FAAH, GHRL
17acetaminophen44 2 50 24 1113.7GHRL, CCK, FAAH
18corticosterone44 61 2411.7HCRT, MC4R, GHRL
19alpha msh449.6AGRP, CCK, MC4R
205-hydroxytryptamine449.6GHRL, CCK, HCRT
21haloperidol44 50 28 2 1113.4FAAH, MC4R, HCRT
22thapsigargin44 6110.4CCK, HCRTR1, HCRT
23opiate449.4HCRT, MC4R, CCK, GHRL
24amide449.4MC4R, FAAH, CCK, GHRL
25gaba449.3GHRL, CCK, HCRT
26carbachol44 28 1111.3HCRT, CCK, GHRL, NPPC
27rimonabant44 28 1111.2HCRT, FAAH, CCK, GHRL
28norepinephrine44 24 1111.2HCRT, CCK, GHRL, NPPC
29cholesterol44 28 24 1112.2HCRT, MC4R, CCK, GHRL
30potassium44 24 1111.1HCRT, HCRTR1, GHRL, NPPC
31oxyntomodulin44 6110.1HCRT, CCK, GHRL, AGRP
32testosterone44 61 24 1112.1HCRT, CCK, GHRL, NPPC
33fatty acid449.0MC4R, FAAH, GHRL, AGRP
34dopamine44 28 24 1112.0HCRT, HCRTR1, MC4R, CCK, GHRL
35dexamethasone44 50 28 1112.0NPPC, GHRL, CCK, HCRT
36forskolin44 50 1110.9NPPC, GHRL, NTF4, CCK
37quinolinic acid44 249.8HCRT, NTF4
38amphetamine44 50 1110.8HCRT, MC4R, CCK, GHRL, AGRP
39cocaine44 119.8HCRT, MC4R, CCK, GHRL, AGRP
40nitric oxide44 24 1110.7HCRT, MC4R, FAAH, GHRL, NPPC
41arginine448.7GHRL, NTF4, CCK, MC4R
42lipid448.6HCRT, MC4R, FAAH, GHRL, NPPC
43histamine44 28 2410.5HCRT, CCK, NTF4, GHRL, NPPC
44acetylcholine44 50 28 24 1112.1HCRT, HCRTR1, CCK, NTF4, GHRL, NPPC
45alanine448.0HCRT, HCRTR1, MC4R, FAAH, NTF4, GHRL
46acth448.0AGRP, NPPC, GHRL, CCK, MC4R, HCRTR1
47glucose447.9HCRT, HCRTR1, MC4R, CCK, GHRL, NPPC
48tyrosine447.9HCRT, FAAH, CCK, NTF4, GHRL, NPPC
49adenylate447.7HCRT, HCRTR1, MC4R, CCK, NTF4, GHRL
50calcium44 50 24 1110.5HCRT, HCRTR1, MC4R, FAAH, CCK, NTF4

GO Terms for genes affiliated with Eating Disorder

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Cellular components related to Eating Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5NPPC, HCRT
2extracellular spaceGO:0056158.5AGRP, NPPC, GHRL, CCK

Biological processes related to Eating Disorder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:0083439.6GHRL, AGRP
2regulation of excitatory postsynaptic membrane potentialGO:0600799.6GHRL, HCRT
3hormone-mediated signaling pathwayGO:0097559.6AGRP, GHRL
4response to insulinGO:0328689.5AGRP, MC4R
5protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.3CCK, HCRT
6feeding behaviorGO:0076319.3HCRTR1, MC4R, AGRP
7eating behaviorGO:0427559.2AGRP, CCK, HCRT
8neuropeptide signaling pathwayGO:0072189.0AGRP, HCRTR1, HCRT

Molecular functions related to Eating Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7NPPC, CCK
2peptide hormone bindingGO:0170469.4MC4R, HCRTR1
3neuropeptide hormone activityGO:0051849.4AGRP, CCK

Products for genes affiliated with Eating Disorder

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Sources for Eating Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet