MCID: ETN001
MIFTS: 56

Eating Disorder malady

Mental diseases, Fetal diseases categories

Summaries for Eating Disorder

About this section
Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Eating disorders are serious behavior problems. they can include severe overeating or not consuming enough food to stay healthy. they also involve extreme concern about your shape or weight. types of eating disorders include anorexia nervosa, in which you become too thin, but you don't eat enough because you think you are fat bulimia nervosa, which involves periods of overeating followed by purging, sometimes through self-induced vomiting or using laxatives binge-eating, which is out-of-control eating women are more likely than men to have eating disorders. they usually start in the teenage years and often occur along with depression, anxiety disorders, and substance abuse. eating disorders can lead to heart and kidney problems and even death. getting help early is important. treatment involves monitoring, talk therapy, nutritional counseling, and sometimes medicines. nih: national institute of mental health

MalaCards: Eating Disorder, also known as eating disorders, is related to bulimia nervosa and obesity. An important gene associated with Eating Disorder is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Adenylate cyclase activating neuropeptides and Syndecan-3-mediated signaling events. The drugs paroxetine and sertraline and the compounds decanoic acid and pramlintide have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:9 A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health.

Wikipedia:66 Eating disorders are conditions defined by abnormal eating habits that may involve either insufficient... more...

Aliases & Classifications for Eating Disorder

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases


Aliases & Descriptions:

eating disorder 9 11
eating disorders 46 35 63


External Ids:

Disease Ontology9 DOID:8670
ICD9CM28 307.50
MeSH36 D001068
ICD1026 F50, F50.9

Related Diseases for Eating Disorder

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Eating Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1bulimia nervosa31.4MC4R, CCK, GHRL
2obesity31.2AGRP, GHRL, CCK, FAAH, MC4R, HCRT
3anorexia nervosa31.0HCRT, MC4R, CCK, GHRL, AGRP
4morbid obesity30.4GHRL, MC4R
5dyspepsia30.3GHRL, CCK
6panic disorder30.3NPPC, CCK
7narcolepsy30.2HCRTR1, HCRT
8diabetes mellitus30.2GHRL, CCK, MC4R
9schizophrenia30.1HCRT, FAAH, CCK
10drug addiction30.1HCRT
11celiac disease30.0CCK, GHRL
12sleep disorder30.0HCRTR1, HCRT
13type 2 diabetes mellitus30.0GHRL, CCK, MC4R
14alzheimer's disease29.8HCRT, FAAH, CCK, NTF4
15personality disorder10.6
16alexithymia10.5
17body dysmorphic disorder10.5
18obsessive-compulsive disorder10.4
19obsessive-compulsive personality disorder10.3
20amenorrhea10.3
21attention deficit hyperactivity disorder10.3
22borderline personality disorder10.3
23agoraphobia10.3
24alcohol abuse10.2
25gastric dilatation10.2
26superior mesenteric artery syndrome10.2
27pathological gambling10.2
28anxiety disorder10.2
29bipolar disorder10.2
30osteoporosis10.2
31pancreatitis10.2
32blindness10.2
33diabetic ketoacidosis10.1
34major depressive disorder10.1
35avoidant personality disorder10.1
36acute pancreatitis10.1
37wernicke-korsakoff syndrome10.1
38hypokalemia10.1
39autism spectrum disorder10.1
40gender identity disorder10.1
41mood disorder10.1
42substance abuse10.1
43substance dependence10.1
44fibromyalgia10.1
45cannabis dependence10.1FAAH
46gastroparesis10.1CCK, GHRL
47glucagonoma10.1CCK, GHRL
48gastrointestinal system disease10.1GHRL, CCK
49hyperinsulinism10.1GHRL, MC4R
50thyroid medullary carcinoma10.1GHRL, CCK

Graphical network of the top 20 diseases related to Eating Disorder:



Diseases related to eating disorder

Symptoms for Eating Disorder

About this section

Drugs & Therapeutics for Eating Disorder

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eating Disorder

Drug clinical trials:

Search ClinicalTrials for Eating Disorder

Search NIH Clinical Center for Eating Disorder

Search CenterWatch for Eating Disorder

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Eating Disorder

About this section

Anatomical Context for Eating Disorder

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Eating Disorder:

34
Heart, Kidney, Testes, Bone, Brain, Liver, Thyroid, Breast, Ovary

Animal Models for Eating Disorder or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Eating Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.0MC4R, FEV, FAAH, CCK, GHRL, NPPC
2MP:00053866.3HCRT, HCRTR1, MC4R, FEV, FAAH, NTF4
3MP:00036316.0AGRP, HCRT, HCRTR1, MC4R, FEV, FAAH

Publications for Eating Disorder

About this section
Sources:
53PubMed
See all sources

Articles related to Eating Disorder:

(show top 50)    (show all 757)
idTitleAuthorsYear
1
Loss of Control over Eating: A Description of the Eating Disorder/Obesity Spectrum in Women. (24338827)
2014
2
Defining Features of Unhealthy Exercise Associated with Disordered Eating and Eating Disorder Diagnoses. (24391457)
2014
3
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
4
Weight bias internalization, depression, and self-Reported health among overweight binge eating disorder patients. (24039219)
2013
5
Changes in depression and quality of life in obese individuals with binge eating disorder: bariatric surgery versus lifestyle modification. (23260806)
2013
6
The MOSAIC study - comparison of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified, anorexia nervosa type: study protocol for a randomized controlled trial. (23721562)
2013
7
Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. (23377749)
2013
8
Parents' experiences of having and caring for a child with an eating disorder. (24044596)
2013
9
Health-related quality of life in obese presurgery patients with and without binge eating disorder, and subdiagnostic binge eating disorders. (23577241)
2013
10
Eating disorder prevention: current evidence-base and future directions. (23658095)
2013
11
Psychometric evaluation of the eating disorder examination adapted for children. (23456853)
2013
12
Dietary intake in population-based adolescents: support for a relationship between eating disorder symptoms, low fatty acid intake and depressive symptoms. (23216519)
2013
13
An examination of food addiction in a racially diverse sample of obese patients with binge eating disorder in primary care settings. (23332551)
2013
14
Personal meaning and eating disorder treatment: comment on Warren et al. (23895285)
2013
15
An exploration of the perceptions and experiences of living with chronic Anorexia Nervosa (cAN) whilst an Inpatient on an Eating Disorders Unit (EDU): An Interpretative Phenomenological Analysis (IPA) Study. (23933950)
2013
16
The use of multiple methods of compensatory behaviors as an indicator of eating disorder severity in treatment-seeking youth. (22331840)
2012
17
Navigating the transition from pediatric to adult eating disorder programs: perspectives of service providers. (22431280)
2012
18
Body-related social comparison and disordered eating among adolescent females with an eating disorder, depressive disorder, and healthy controls. (23112914)
2012
19
Eating disorder detection through personality traits and self-concept. (23221394)
2012
20
Sleep disturbances and binge eating disorder symptoms during and after pregnancy. (23024439)
2012
21
Active Reward Processing during Human Sleep: Insights from Sleep-Related Eating Disorder. (23205019)
2012
22
The impact of age and BMI on Eating Disorder Examination Questionnaire (EDE-Q) scores in a community sample. (22365803)
2012
23
Significance of overvaluation of shape and weight in an ethnically diverse sample of obese patients with binge-eating disorder in primary care settings. (22449893)
2012
24
Effect of a dissonance-based prevention program on risk for eating disorder onset in the context of eating disorder risk factors. (21975593)
2012
25
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. (22911880)
2012
26
An experimental exploration of behavioral and cognitive-emotional aspects of intolerance of uncertainty in eating disorder patients. (21555203)
2011
27
A comparative analysis of Type 2 diabetes and binge eating disorder in a bariatric sample. (21741014)
2011
28
Stability of eating disorder diagnostic classifications in adolescents: five-year longitudinal findings from a population-based study. (22352971)
2011
29
Parental eating disorder symptoms and observations of mealtime interactions with children. (21414457)
2011
30
Mortality 6 years after inpatient treatment of female Japanese patients with eating disorders associated with alcoholism. (21545673)
2011
31
The STRATOB study: design of a randomized controlled clinical trial of Cognitive Behavioral Therapy and Brief Strategic Therapy with telecare in patients with obesity and binge-eating disorder referred to residential nutritional rehabilitation. (21554734)
2011
32
The relationship between alexithymia and maladaptive perfectionism in eating disorders: a mediation moderation analysis methodology. (22290034)
2011
33
Gastric adenocarcinoma mistakenly diagnosed as an eating disorder: case report. (19365820)
2010
34
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
35
Lack of association between polymorphisms in cannabinoid receptor gene (CNR1) and fatty acid amide hydroxylase gene (FAAH) and eating disorders in a preliminary study. (19801960)
2009
36
Validity of the Eating Disorders Examination-Questionnaire when used with adolescents with bulimia nervosa and atypical bulimia nervosa. (20179414)
2009
37
Low serum BDNF and food intake regulation: a possible new explanation of the pathophysiology of eating disorders. (19152823)
2009
38
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
39
Cannabinoids in eating disorders and obesity. (17952656)
2007
40
Gastrointestinal disturbances in eating disorders: clinical and neurobiological aspects. (16962383)
2006
41
Emerging drugs for eating disorder treatment. (16634704)
2006
42
Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. (16131812)
2005
43
Subclinical eating disorder, polycystic ovary syndrome- is there any connection between these two conditions through leptin- a twin study. (16570705)
2005
44
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects. (16030156)
2005
45
DPP IV, immune parameters, and psychometrical variables in patients with eating disorders. (12675253)
2003
46
Serum leptin level and restrained eating: study with the Eating Disorder Examination. (11890967)
2002
47
Insulin-like growth factor 1 (IGF-1), a nutritional marker in patients with eating disorders. (11407872)
2001
48
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
49
Aspects of the neuroendocrine control of somatotropic function in calorically restricted dogs and patients with eating disorders: studies with cholinergic drugs. (8739115)
1996
50
Hormonal circadian rhythms in eating disorders. (2334743)
1990

Variations for Eating Disorder

About this section

Expression for genes affiliated with Eating Disorder

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eating Disorder

Search GEO for disease gene expression data for Eating Disorder.

Pathways for genes affiliated with Eating Disorder

About this section
Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome, 31KEGG
See all sources

Compounds for genes affiliated with Eating Disorder

About this section
Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 25HMDB, 3BitterDB
See all sources

Compounds related to Eating Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1decanoic acid46 30 1212.2GHRL, CCK
2pramlintide46 1211.1GHRL, CCK
3pirenzepine46 30 1212.0GHRL, CCK
4intralipid4610.0GHRL, CCK
5npff469.9CCK, HCRT
6enterostatin469.9CCK, HCRT
7gamma-hydroxybutyrate469.9HCRT, GHRL
8l-nmma469.8CCK, NPPC, GHRL
9atropine46 30 1211.8GHRL, CCK, NPPC
10tetrapeptide469.8NPPC, CCK, MC4R
11octadecaneuropeptide469.7CCK, GHRL, HCRT
12orlistat46 62 1211.7CCK, GHRL
13ether46 5210.7FAAH, GHRL
14olanzapine46 52 30 25 1213.7MC4R, GHRL, FAAH
15c-peptide469.7GHRL, HCRT, CCK
16corticosterone46 62 2511.7HCRT, GHRL, MC4R
17acetaminophen46 3 52 25 1213.7GHRL, CCK, FAAH
18clozapine46 30 52 1212.7MC4R, GHRL, FAAH
19alpha msh469.6AGRP, CCK, MC4R
205-hydroxytryptamine469.6HCRT, GHRL, CCK
21haloperidol46 52 30 3 1213.4MC4R, HCRT, FAAH
22thapsigargin46 6210.4CCK, HCRT, HCRTR1
23opiate469.4CCK, GHRL, HCRT, MC4R
24amide469.4CCK, GHRL, FAAH, MC4R
25gaba469.3HCRT, GHRL, CCK
26carbachol46 30 1211.3HCRT, CCK, GHRL, NPPC
27rimonabant46 30 1211.2GHRL, CCK, FAAH, HCRT
28norepinephrine46 25 1211.2HCRT, CCK, GHRL, NPPC
29cholesterol46 30 25 1212.2GHRL, MC4R, HCRT, CCK
30potassium46 25 1211.1NPPC, HCRTR1, GHRL, HCRT
31oxyntomodulin46 6210.1HCRT, CCK, AGRP, GHRL
32testosterone46 62 25 1212.1HCRT, CCK, NPPC, GHRL
33fatty acid469.0GHRL, FAAH, MC4R, AGRP
34dopamine46 30 25 1212.0HCRT, HCRTR1, MC4R, GHRL, CCK
35dexamethasone46 52 30 1212.0GHRL, CCK, NPPC, HCRT
36forskolin46 52 1210.9GHRL, CCK, NTF4, NPPC
37quinolinic acid46 259.8NTF4, HCRT
38amphetamine46 52 1210.8GHRL, AGRP, HCRT, CCK, MC4R
39cocaine46 129.8GHRL, MC4R, CCK, HCRT, AGRP
40nitric oxide46 25 1210.7GHRL, FAAH, HCRT, MC4R, NPPC
41arginine468.7MC4R, GHRL, CCK, NTF4
42lipid468.6MC4R, HCRT, FAAH, NPPC, GHRL
43histamine46 30 2510.5CCK, HCRT, NPPC, GHRL, NTF4
44acetylcholine46 52 30 25 1212.1NPPC, GHRL, NTF4, HCRTR1, HCRT, CCK
45alanine468.0GHRL, HCRT, HCRTR1, MC4R, FAAH, NTF4
46acth468.0HCRTR1, HCRT, MC4R, CCK, NPPC, AGRP
47glucose467.9AGRP, CCK, NPPC, GHRL, HCRT, MC4R
48tyrosine467.9GHRL, NTF4, CCK, NPPC, FAAH, HCRT
49adenylate467.7MC4R, HCRTR1, CCK, NTF4, NPPC, HCRT
50calcium46 52 25 1210.5NPPC, CCK, FAAH, MC4R, NTF4, HCRTR1

GO Terms for genes affiliated with Eating Disorder

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Eating Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5NPPC, HCRT
2extracellular spaceGO:0056158.5AGRP, NPPC, GHRL, CCK

Biological processes related to Eating Disorder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:0083439.6AGRP, GHRL
2regulation of excitatory postsynaptic membrane potentialGO:0600799.6GHRL, HCRT
3hormone-mediated signaling pathwayGO:0097559.6AGRP, GHRL
4response to insulinGO:0328689.5MC4R, AGRP
5protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.3HCRT, CCK
6feeding behaviorGO:0076319.3HCRTR1, MC4R, AGRP
7eating behaviorGO:0427559.2AGRP, CCK, HCRT
8neuropeptide signaling pathwayGO:0072189.0HCRT, HCRTR1, AGRP

Molecular functions related to Eating Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7NPPC, CCK
2peptide hormone bindingGO:0170469.4MC4R, HCRTR1
3neuropeptide hormone activityGO:0051849.4AGRP, CCK

Products for genes affiliated with Eating Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eating Disorder

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet