MCID: ECC004
MIFTS: 36

Eccrine Porocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Eccrine Porocarcinoma

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Aliases & Descriptions for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 11 48 50 39 13 68
Eccrine Porocarcinoma of Skin 11 48
 
Malignant Eccrine Poroma 11 48
Porocarcinoma 11 48

Classifications:



External Ids:

Disease Ontology11 DOID:7566
MeSH39 D057090
NCIt45 C5560

Summaries for Eccrine Porocarcinoma

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NIH Rare Diseases:48 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. they affect the eccrine sweat glands, which are the major sweat glands of the body. eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). they are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. treatment usually involves surgery to remove the tumor. last updated: 12/13/2016

MalaCards based summary: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to squamous cell carcinoma and vulvar eccrine porocarcinoma. An important gene associated with Eccrine Porocarcinoma is VIM (Vimentin), and among its related pathways are Interleukin-4 and 13 signaling and Cytoskeletal Signaling. Affiliated tissues include skin, lymph node and colon.

Wikipedia:71 A malignant acrospiroma (also known as hidradenocarcinoma, and \"Spiradenocarcinoma\") is a sweat gland... more...

Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.3KRT1, KRT10
2vulvar eccrine porocarcinoma12.2
3lupus - neurological sequelae10.2S100B, VIM
4benign schwannoma10.2S100B, VIM
5jejunal neuroendocrine tumor10.2S100B, VIM
6bradyopsia10.2KRT1, KRT10
7erdheim-chester disease10.2KRT1, KRT10
8palmoplantar keratoderma, nonepidermolytic10.2KRT1, KRT10
9cavernous sinus meningioma10.2S100B, VIM
10episodic angioedema with eosinophilia10.2KRT1, KRT10
11ciliary dyskinesia, primary, 1, with or without situs inversus10.2KRT1, KRT10
12hypogonadotropic hypogonadism-retinitis pigmentosa syndrome10.2S100B, VIM
13dyslexia10.2S100B, VIM
14stomach diverticulosis10.2S100B, VIM
15mixed cell adenoma10.2KRT1, KRT10
16skin glomus tumor10.2S100B, VIM
17immunodeficiency due to a classical component pathway complement deficiency10.2MUC1, VIM
18marfanoid hypermobility syndrome10.2MUC1, VIM
19keratosis palmoplantaris striata iii10.2KRT1, KRT10
20autosomal recessive stickler syndrome10.2MUC1, VIM
21endometrial stromal sarcoma10.2MUC1, VIM
22onychocytic matricoma10.2S100B, VIM
23tanycytic ependymoma10.2MUC1, VIM
24bladder adenocarcinoma10.2MUC1, VIM
25avian influenza10.2MUC1, VIM
26enchondromatosis dwarfism deafness10.2S100B, VIM
27testicular granulosa cell tumor10.2MUC1, VIM
28petrous apex meningioma10.1MUC1, VIM
29lymphangiosarcoma10.1MUC1, VIM
30progeria10.1MUC1, VIM
31colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.1KRT1, KRT10
32coronary stenosis10.1MUC1, VIM
33sebaceous adenoma10.1MUC1, VIM
34his bundle tachycardia10.1S100B, VIM
35anal gland neoplasm10.1MUC1, VIM
36cauda equina intradural extramedullary astrocytoma10.1MUC1, VIM
37gestational trophoblastic neoplasm10.1MUC1, VIM
38appendix mucinous cystadenocarcinoma10.1MUC1, VIM
39chondroblastoma10.1MUC1, VIM
40mesenchymoma10.1MUC1, VIM
41omodysplasia 210.1MUC1, VIM
42scott syndrome10.1KRT1, KRT10
43subependymal glioma10.1MUC1, VIM
44congenital muscular dystrophy with hyperlaxity10.1MUC1, VIM
45ovarian epithelial cancer10.1S100B, VIM
46differentiating neuroblastoma10.1MUC1, VIM
47complication after organ transplantation10.1MUC1, STAT3
48bowen's disease10.1
49carotid artery thrombosis10.1KRT1, KRT10
50ichthyosis histrix, curth-macklin type10.1KRT1, KRT10

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Symptoms & Phenotypes for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
nivolumabapprovedPhase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
2ImmunoglobulinsPhase 26394
3Antibodies, MonoclonalPhase 24039
4AntibodiesPhase 26394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersNot yet recruitingNCT02978625Phase 2

Search NIH Clinical Center for Eccrine Porocarcinoma


Cochrane evidence based reviews: eccrine porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

36
Skin, Lymph node, Colon, Lung

Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. (28087039)
2017
2
Eccrine porocarcinoma of the vulva: a case report and review of the literature. (27832810)
2016
3
Eccrine Porocarcinoma Presenting as a Hand Cyst. (27593487)
2016
4
Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report. (27085107)
2016
5
Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature. (26894080)
2016
6
Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment. (27721767)
2016
7
In-transit metastasis of advanced eccrine porocarcinoma. (26234455)
2015
8
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. (25515648)
2015
9
Eccrine porocarcinoma of the thumb in a patient with chronic exposure to benzene glue. (26078532)
2015
10
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. (26333057)
2015
11
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. (26205087)
2015
12
Eccrine Porocarcinoma of Scalp: a Rare Case Report. (26516328)
2015
13
Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. (25742554)
2015
14
Metastatic eccrine porocarcinoma successfully treated with carboplatin and epirubicin chemotherapy. (26073009)
2015
15
Response to taxane-based chemotherapy in metastatic eccrine porocarcinoma with extensive cutaneous involvement. (26837980)
2015
16
Eccrine porocarcinoma: A wolf in sheep's clothing. (25803156)
2015
17
Eccrine porocarcinoma with extensive cutaneous metastases. (26566927)
2015
18
Eccrine porocarcinoma mimicking a venous leg ulcer. (26400442)
2015
19
Intralesional Photodynamic Therapy for Eccrine Porocarcinoma. (26079590)
2015
20
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. (25972690)
2015
21
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. (25984905)
2015
22
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. (25076888)
2014
23
Eccrine Porocarcinoma of the Eyelid in a Non-Caucasian Patient. (24841732)
2014
24
Rapidly growing eccrine porocarcinoma of the face in a pregnant woman. (24621740)
2014
25
A Rare Case of Eccrine Porocarcinoma of the Eyelid. (24576261)
2014
26
Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrheic Keratoses. (24909550)
2014
27
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. (24803063)
2014
28
Eccrine porocarcinoma: a report of 2 cases and review of the literature. (24505584)
2014
29
Metastatic eccrine porocarcinoma. (24087778)
2013
30
Successful management of metastatic eccrine porocarcinoma. (24282649)
2013
31
Eccrine porocarcinoma: a case report. (24551693)
2013
32
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). (24016659)
2013
33
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. (24003279)
2013
34
Eccrine porocarcinoma: clinical and pathological report of eight cases. (24403888)
2013
35
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. (23917787)
2013
36
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. (23773127)
2013
37
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. (22108500)
2012
38
Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report. (22689795)
2012
39
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. (22150617)
2012
40
Eccrine porocarcinoma arising within an area of Bowen disease. (21973218)
2012
41
Eccrine porocarcinoma of the vulva: a case report and review of literature. (21131825)
2011
42
Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. (21711331)
2011
43
Eccrine porocarcinoma of the external ear. (21853429)
2011
44
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. (21859481)
2011
45
Eccrine porocarcinoma presenting with unusual clinical manifestations: a case report and review of the literature. (22028580)
2011
46
Primary eccrine porocarcinoma of the finger with transit forearm and axillary metastasis. (21042176)
2011
47
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. (22693407)
2011
48
Metastatic eccrine porocarcinoma: report of a case and review of the literature. (21410982)
2011
49
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. (20976127)
2010
50
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report. (20492705)
2010

Variations for Eccrine Porocarcinoma

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Cosmic variations for Eccrine Porocarcinoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM521KRASskin,hand,carcinoma,NSc.35G>Ap.G12D4
2COSM17596PTCH1skin,hand,carcinoma,NSc.863G>Ap.G288D4
3COSM17602PTCH1skin,hand,carcinoma,NSc.1922C>Tp.P641L4
4COSM17597PTCH1skin,hand,carcinoma,NSc.1977G>Ap.Q659Q4

Expression for genes affiliated with Eccrine Porocarcinoma

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Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for genes affiliated with Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2MUC1, STAT3, VIM
29.2KRT10, MUC1, VIM
3
Show member pathways
8.7KRT1, KRT10, KRT15

GO Terms for genes affiliated with Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.1KRT1, KRT10
2intermediate filamentGO:00058828.3KRT1, KRT10, KRT15, VIM

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1astrocyte differentiationGO:004870810.0S100B, STAT3
2peptide cross-linkingGO:00181499.7KRT1, KRT10
3skin epidermis developmentGO:00987739.5KRT1, KRT10
4cornificationGO:00702689.3KRT1, KRT10, KRT15
5keratinizationGO:00314249.2KRT1, KRT10, KRT15

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.6KRT15, VIM
2structural constituent of epidermisGO:00302809.5KRT1, KRT10

Sources for Eccrine Porocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet