MCID: ECC004
MIFTS: 52

Eccrine Porocarcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Eccrine Porocarcinoma

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Wikipedia:65 A malignant acrospiroma (also known as hidradenocarcinoma, and \"Spiradenocarcinoma\") is a sweat gland... more...

MalaCards based summary: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to cervical cancer and retinoblastoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are IL12-mediated signaling events and IL-5 Signaling Pathway. The compounds hematoxylin and biotin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and colon, and related mouse phenotypes are pigmentation and reproductive system.

Aliases & Classifications for Eccrine Porocarcinoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Eccrine Porocarcinoma, Aliases & Descriptions:

Name: Eccrine Porocarcinoma 8 44 62
Eccrine Porocarcinoma of Skin 8 62
 
Malignant Eccrine Poroma 8 62
Porocarcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:7566
NCIt39 C5560
MeSH34 D057090

Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1cervical cancer30.2TP53, TP73, CDKN2A
2retinoblastoma29.5ATF2, TP53, TP73, STAT3, CDKN2A
3melanoma29.5ATF2, TP53, TP73, STAT3, CDKN2A
4vulvar eccrine porocarcinoma10.5
5actinic keratosis10.5TP53
6choroid plexus papilloma10.4TP53
7lymphangitis10.4
8cervicitis10.4
9keratosis10.4
10acrospiroma10.4
11kidney cancer10.3TP53
12syringoma10.3MUC1, KRT1
13epithelioid sarcoma10.3MUC1, KRT1
14chordoma10.3MUC1, KRT1
15neuroendocrine carcinoma10.3KRT1, MUC1
16synovial sarcoma10.3MUC1, KRT1
17malignant mixed mullerian tumor10.3MUC1, TP53
18lymphedema10.2
19erysipeloid10.2
20basaloid squamous cell carcinoma10.2
21seborrheic keratosis10.2
22epidermal nevus10.2
23neurofibroma10.2MUC1, TP73
24ependymoma10.2TP73, MUC1
25malignant peripheral nerve sheath tumor10.2CDKN2A, MUC1
26leiomyosarcoma10.2TP53, MUC1
27oropharyngeal cancer, adult10.2TP53, CDKN2A
28oligodendroglioma10.2CDKN2A, TP73
29li-fraumeni syndrome10.2TP53, CDKN2A
30nasopharynx carcinoma10.2TP53, CDKN2A
31cervical squamous cell carcinoma10.1CDKN2A, TP73
32cervical intraepithelial neoplasia10.1CDKN2A, TP73
33leukemia, acute lymphoblastic 310.1TP73, CDKN2A
34meningioma10.1TP73, MUC1, KRT1
35barrett's esophagus10.1TP53, CDKN2A
36bladder carcinoma in situ10.1CDKN2A, TP53
37malignant mesothelioma10.1CDKN2A, MUC1
38cholangiocarcinoma10.1TP53, MUC1
39esophageal cancer10.1CDKN2A, TP53
40skin benign neoplasm10.1STAT3, KRT1
41anaplastic large cell lymphoma10.1STAT3, MUC1
42bladder carcinoma10.0CDKN2A, TP53
43thyroid hurthle cell carcinoma10.0TP73, TP53
44amelanotic melanoma10.0
45lung small cell carcinoma10.0CDKN2A, MUC1, TP53
46lung cancer10.0TP53, MUC1, CDKN2A
47papillary thyroid carcinoma10.0KRT1, STAT3
48laryngeal squamous cell carcinoma10.0CDKN2A, TP73, TP53
49grade iii astrocytoma10.0TP53, TP73, CDKN2A
50papilloma9.9TP53, TP73, CDKN2A

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Symptoms for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Eccrine Porocarcinoma

Search NIH Clinical Center for Eccrine Porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

32
Skin, Lymph node, Colon, Lung

Animal Models for Eccrine Porocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7TP53, KRT1, CDKN2A
2MP:00053898.1CDKN2A, STAT3, TP73, TP53
3MP:00053818.0TP53, TP73, MUC1, STAT3, CDKN2A
4MP:00053707.9ATF2, TP53, MUC1, STAT3, CDKN2A
5MP:00053797.9TP53, TP73, MUC1, STAT3, CDKN2A
6MP:00028737.8ATF2, TP53, MUC1, STAT3
7MP:00053887.8ATF2, TP53, TP73, STAT3, CDKN2A
8MP:00053857.8ATF2, TP53, TP73, STAT3, KRT1
9MP:00053907.7ATF2, TP53, TP73, STAT3, CDKN2A
10MP:00053807.7ATF2, TP53, TP73, STAT3, CDKN2A
11MP:00053867.6CDKN2A, STAT3, TP73, TP53, ATF2
12MP:00107717.5ATF2, TP53, MUC1, STAT3, KRT1, CDKN2A
13MP:00020067.5CDKN2A, STAT3, MUC1, TP73, TP53, ATF2
14MP:00053917.5ATF2, TP53, TP73, MUC1, STAT3, CDKN2A
15MP:00053847.4CDKN2A, STAT3, TP73, TP53, ATF2
16MP:00053977.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
17MP:00053877.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
18MP:00036317.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
19MP:00053787.3ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
20MP:00107687.3ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
21MP:00053767.1ATF2, TP53, TP73, MUC1, STAT3, KRT1

Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. (25076888)
2014
2
Eccrine porocarcinoma: a report of 2 cases and review of the literature. (24505584)
2014
3
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. (24803063)
2014
4
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. (24003279)
2013
5
Eccrine porocarcinoma: clinical and pathological report of eight cases. (24403888)
2013
6
Successful management of metastatic eccrine porocarcinoma. (24282649)
2013
7
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. (23773127)
2013
8
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. (23917787)
2013
9
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. (22108500)
2012
10
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. (22150617)
2012
11
Eccrine porocarcinoma of the vulva: a case report and review of literature. (21131825)
2011
12
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. (21859481)
2011
13
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. (22693407)
2011
14
Aggressive eccrine porocarcinoma associated with haematological disorders: report of two cases. (20518919)
2010
15
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. (20976127)
2010
16
A case of clear cell eccrine porocarcinoma. (20711273)
2010
17
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report. (20492705)
2010
18
Recurrent pigmented eccrine porocarcinoma presenting as carcinoma erysipeloides. (19747328)
2009
19
Eccrine porocarcinoma. (19076620)
2008
20
Eccrine porocarcinoma of the upper eyelid. (18520840)
2008
21
Eccrine porocarcinoma: a rare but sometimes fatal malignant neoplasm. (17338701)
2007
22
Metastatic eccrine porocarcinoma detected on FDG PET/CT. (17710036)
2007
23
Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. (17004985)
2007
24
Eccrine porocarcinoma of the face involving eyelids: a rare case report. (17294909)
2006
25
Eccrine porocarcinoma arising from preexisting eccrine poroma of the scalp after radiotherapy for cervical cancer. (17083898)
2006
26
Eccrine porocarcinoma. (16638385)
2006
27
Eccrine porocarcinoma of the upper eyelid. (16197432)
2005
28
Eccrine porocarcinoma and eccrine poroma arising in a scar. (15214932)
2004
29
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. (15206695)
2004
30
Eccrine porocarcinoma of the penis. (12544320)
2003
31
Metastatic eccrine porocarcinoma: a 5.6-year follow-up study of a patient treated with a combined therapeutic protocol. (14725669)
2003
32
Eccrine porocarcinoma: A case report and review of the literature. (24115860)
2003
33
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. (11395548)
2001
34
Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. (11332156)
2001
35
A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: biological characterization and clinical aggressiveness. (11053985)
2000
36
Eccrine porocarcinoma treated with Mohs micrographic surgery: A report of five cases. (10594609)
1999
37
Eccrine porocarcinoma: a case report. (10561775)
1999
38
Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient. (10491509)
1999
39
Eccrine porocarcinoma with melanocyte colonization. (9580812)
1998
40
Eccrine porocarcinoma. Report of nine cases. (9357503)
1997
41
Metastasizing eccrine porocarcinoma: report of a case and review of the literature. (8912607)
1996
42
Eccrine porocarcinoma. (8828278)
1996
43
A case of multiple eccrine porocarcinoma with stepping-stone distribution on the foot. (7650246)
1995
44
Eccrine porocarcinoma. (8159010)
1994
45
A unique case of extramammary Paget's disease. Derivation from eccrine porocarcinoma? (1335216)
1992
46
A histopathological and ultrastructural study of eccrine porocarcinoma with special reference to its subtypes. (1317619)
1992
47
Eccrine porocarcinoma of the face. (1325487)
1992
48
Eccrine porocarcinoma. (1653154)
1991
49
Three cases of eccrine porocarcinoma. (3015186)
1986
50
Eccrine porocarcinoma: a case report with light microscopy and ultrastructure. (6296749)
1982

Variations for Eccrine Porocarcinoma

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Expression for genes affiliated with Eccrine Porocarcinoma

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Expression patterns in normal tissues for genes affiliated with Eccrine Porocarcinoma

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Pathways for genes affiliated with Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3ATF2, STAT3
29.3STAT3, ATF2
3
Show member pathways
9.3STAT3, ATF2
49.3STAT3, ATF2
5
Show member pathways
IFN-gamma pathway37
9.3STAT3, ATF2
6
Show member pathways
RAC1 signaling pathway37
9.3STAT3, ATF2
79.1TP53, CDKN2A
89.1TP53, CDKN2A
99.1CDKN2A, TP53
109.1TP53, CDKN2A
119.1TP53, CDKN2A
12
Show member pathways
9.1TP53, CDKN2A
139.1TP53, ATF2
149.1TP53, ATF2
15
Show member pathways
9.0STAT3, TP53
16
Show member pathways
9.0CDKN2A, ATF2, KRT1
17
Show member pathways
8.7TP53, CDKN2A, TP73
18
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.7CDKN2A, TP73, TP53
19
Show member pathways
DNA damage response37
8.7TP73, CDKN2A, TP53
20
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.7TP53, TP73, CDKN2A
21
Show member pathways
8.7TP73, CDKN2A, TP53
228.7ATF2, TP53, TP73
23
Show member pathways
ATM Signaling Pathway37
8.7TP53, TP73, ATF2
248.7MUC1, TP53, STAT3
258.6ATF2, CDKN2A, TP53
26
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.6TP73, STAT3, TP53
27
Show member pathways
8.5STAT3, TP53, CDKN2A
28
Show member pathways
8.5STAT3, CDKN2A, TP53
298.5TP53, CDKN2A, STAT3
308.5STAT3, TP53, CDKN2A
31
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
8.5TP53, STAT3, ATF2
32
Show member pathways
8.5STAT3, TP53, ATF2
33
Show member pathways
8.5ATF2, TP53, STAT3
34
Show member pathways
8.5ATF2, TP53, STAT3
35
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5ATF2, TP53, STAT3
36
Show member pathways
8.5TP53, STAT3, ATF2
378.5STAT3, TP53, ATF2
38
Show member pathways
8.1STAT3, ATF2, TP53, TP73
398.0ATF2, TP53, STAT3, CDKN2A
40
Show member pathways
8.0STAT3, TP53, CDKN2A, ATF2
41
Show member pathways
7.6STAT3, TP53, MUC1, ATF2, CDKN2A

Compounds for genes affiliated with Eccrine Porocarcinoma

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Compounds related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1hematoxylin449.6CDKN2A, KRT1, MUC1
2biotin44 24 1111.5KRT1, CDKN2A, MUC1
3[alcl]449.5STAT3, MUC1
4acnu449.5CDKN2A, TP53
5hpvs449.4TP53, CDKN2A
6chloramphenicol44 2 50 1112.3MUC1, CDKN2A, TP73
7olomoucine44 1110.3TP53, CDKN2A
85-methylcytosine44 2410.3TP53, CDKN2A
9gemcitabine44 50 1111.2MUC1, TP53, TP73
10temozolomide44 1110.2TP53, CDKN2A
11agar449.2CDKN2A, STAT3, MUC1
12crcs449.2TP53, CDKN2A, MUC1
13hmba449.1TP53, CDKN2A
14cytarabine44 50 1111.1TP53, MUC1, CDKN2A
15o6-methylguanine449.1CDKN2A, TP73, TP53
16vincristine44 50 1111.0CDKN2A, TP73, TP53
17camptothecin44 61 1111.0TP73, CDKN2A, TP53
1812-o-tetradecanoylphorbol 13-acetate449.0STAT3, ATF2, KRT1, MUC1
19roscovitine448.9CDKN2A, STAT3, TP53
20flavopiridol44 119.9TP53, STAT3, CDKN2A
21sp 60012544 619.9ATF2, STAT3, TP53
22testosterone44 61 24 1111.8MUC1, STAT3, CDKN2A, KRT1
23docetaxel44 50 61 1111.8STAT3, CDKN2A, TP53
24aflatoxin b144 249.8CDKN2A, TP53
25egcg448.8CDKN2A, STAT3, TP53
26retinoid448.8STAT3, TP53, KRT1
27mg 13244 619.8TP53, CDKN2A, STAT3
28arsenite44 249.8CDKN2A, STAT3, TP53
29adriamycin448.7TP53, CDKN2A, TP73, MUC1
30butyrate448.6ATF2, MUC1, TP53, CDKN2A
31n acetylcysteine448.6CDKN2A, TP53, STAT3
325-aza-2deoxycytidine448.5TP53, STAT3, TP73, CDKN2A
33sb 20358044 619.4TP53, ATF2, STAT3
34paclitaxel44 50 1110.4ATF2, TP53, STAT3, CDKN2A
35tyrosine448.4MUC1, KRT1, STAT3, ATF2, TP73
36cycloheximide448.3STAT3, ATF2, CDKN2A, TP53
37progesterone44 28 61 24 1112.3CDKN2A, TP53, MUC1, TP73, KRT1
38h2o2448.3ATF2, TP53, STAT3, CDKN2A
395fluorouracil448.1MUC1, TP73, TP53, CDKN2A, STAT3
40actinomycin d448.1CDKN2A, MUC1, STAT3, TP53, TP73
41vegf448.1TP73, TP53, MUC1, CDKN2A, STAT3
42arginine448.1CDKN2A, KRT1, STAT3, TP73, TP53
43threonine448.0KRT1, STAT3, MUC1, TP73, ATF2, CDKN2A
44doxorubicin44 50 1110.0ATF2, STAT3, TP53, CDKN2A, TP73
45oligonucleotide447.9STAT3, TP73, TP53, CDKN2A, ATF2
46paraffin447.7KRT1, TP53, TP73, MUC1, STAT3, CDKN2A
47serine447.6TP53, CDKN2A, KRT1, STAT3, MUC1, ATF2
48cisplatin44 50 61 1110.6CDKN2A, STAT3, TP53, MUC1, ATF2, TP73
49estrogen447.2KRT1, ATF2, TP53, MUC1, STAT3, CDKN2A
50retinoic acid44 248.2STAT3, MUC1, KRT1, CDKN2A, TP53, TP73

GO Terms for genes affiliated with Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.3MUC1, TP53
2nuclear bodyGO:0166049.2CDKN2A, TP53
3chromatinGO:0007859.1TP53, TP73
4nucleoplasmGO:0056548.0CDKN2A, STAT3, TP53, ATF2
5nucleolusGO:0057307.7CDKN2A, STAT3, TP53, ATF2

Biological processes related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP73
2replicative senescenceGO:0903999.4CDKN2A, TP53
3response to X-rayGO:0101659.4TP73, TP53
4release of cytochrome c from mitochondriaGO:0018369.4TP73, TP53
5positive regulation of cell cycle arrestGO:0711589.4TP53, CDKN2A
6response to gamma radiationGO:0103329.3TP73, TP53
7protein tetramerizationGO:0512629.3TP53, TP73
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.3TP53, TP73
9cellular response to UVGO:0346449.2TP73, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.2TP53, MUC1
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.1MUC1, TP73, TP53
12cell cycle arrestGO:0070509.0CDKN2A, TP73, TP53
13cellular response to DNA damage stimulusGO:0069748.9ATF2, TP53, TP73
14Ras protein signal transductionGO:0072658.8CDKN2A, TP53
15negative regulation of transcription from RNA polymerase II promoterGO:0001228.6STAT3, TP73, TP53
16positive regulation of transcription, DNA-templatedGO:0458938.4TP53, TP73, STAT3, CDKN2A
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CDKN2A, STAT3, TP73, TP53

Molecular functions related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.3CDKN2A, TP53
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.1TP53, ATF2
3damaged DNA bindingGO:0036849.1TP53, TP73
4protein phosphatase bindingGO:0199038.7STAT3, TP53
5transcription regulatory region DNA bindingGO:0442128.7STAT3, TP73, TP53
6chromatin bindingGO:0036828.7TP73, TP53, ATF2
7p53 bindingGO:0020398.5CDKN2A, MUC1, TP73, TP53
8transcription factor bindingGO:0081348.3TP53, TP73, STAT3, CDKN2A
9sequence-specific DNA binding transcription factor activityGO:0037008.1ATF2, TP53, TP73, STAT3
10protein kinase bindingGO:0199017.8ATF2, TP53, TP73, STAT3, CDKN2A
11protein bindingGO:0055156.9ATF2, TP53, TP73, MUC1, STAT3, KRT1

Products for genes affiliated with Eccrine Porocarcinoma

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Sources for Eccrine Porocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet