MCID: ECC004
MIFTS: 34

Eccrine Porocarcinoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Eccrine Porocarcinoma

MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 50 52 42 14 69
Eccrine Porocarcinoma of Skin 12 50
Malignant Eccrine Poroma 12 50
Porocarcinoma 12 50

Classifications:



External Ids:

Disease Ontology 12 DOID:7566
MeSH 42 D057090
NCIt 47 C5560
SNOMED-CT 64 128685001 254708001
UMLS 69 C1266065

Summaries for Eccrine Porocarcinoma

NIH Rare Diseases : 50 eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. they affect the eccrine sweat glands, which are the major sweat glands of the body. eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). they are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. treatment usually involves surgery to remove the tumor. last updated: 12/13/2016

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to vulvar eccrine porocarcinoma and immune-mediated encephalomyelitis. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs nivolumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and colon.

Wikipedia : 72 A malignant acrospiroma (also known as hidradenocarcinoma, and \"Spiradenocarcinoma\") is a sweat gland... more...

Related Diseases for Eccrine Porocarcinoma

Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 vulvar eccrine porocarcinoma 12.2
2 immune-mediated encephalomyelitis 10.6 S100B VIM
3 benallegue lacete syndrome 10.6 S100B VIM
4 neurogenic thoracic outlet syndrome 10.6 S100B VIM
5 small intestine neuroendocrine neoplasm 10.5 S100B VIM
6 papillary glioneuronal tumor 10.5 S100B VIM
7 malignant breast melanoma 10.5 S100B VIM
8 juvenile xanthogranuloma 10.5 S100B VIM
9 oligomeganephronic renal hypoplasia 10.5 S100B VIM
10 skin glomus tumor 10.5 S100B VIM
11 enamel hypoplasia cataract hydrocephaly 10.5 S100B VIM
12 hip subluxation 10.5 S100B VIM
13 osteopetrosis and infantile neuroaxonal dystrophy 10.4 S100B VIM
14 2q31.1 microdeletion syndrome 10.4 MUC1 VIM
15 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.4 MUC1 VIM
16 laryngeal neuroendocrine tumor 10.3 MUC1 VIM
17 mannose-binding lectin protein deficiency 10.3 MUC1 VIM
18 vulvar angiokeratoma 10.3 MUC1 VIM
19 pyoderma 10.3 MUC1 VIM
20 bladder colloid adenocarcinoma 10.3 MUC1 VIM
21 cellular ependymoma 10.3 MUC1 VIM
22 logopenic progressive aphasia 10.3 MUC1 S100B
23 lymphangiosarcoma 10.3 MUC1 VIM
24 heiner syndrome 10.3 MUC1 S100B
25 persian gulf syndrome 10.3 MUC1 VIM
26 diffuse meningeal melanocytosis 10.3 MUC1 VIM
27 meningitis and encephalitis 10.3 MUC1 S100B
28 dedifferentiated liposarcoma 10.3 MUC1 S100B
29 hypoglossal nerve neoplasm 10.3 S100B VIM
30 fallopian tube germ cell cancer 10.3 MUC1 VIM
31 simple cryoglobulinemia 10.3 MUC1 S100B
32 ovary papillary carcinoma 10.3 MUC1 VIM
33 childhood pleomorphic rhabdomyosarcoma 10.3 MUC1 VIM
34 mucinous ovarian cystadenoma 10.3 MUC1 S100B
35 enteric pattern testicular yolk sac tumor 10.3 MUC1 S100B
36 pancreatic serous cystadenoma 10.3 MUC1 VIM
37 sebaceous adenoma 10.3 MUC1 VIM
38 gastric papillary adenocarcinoma 10.3 MUC1 S100B
39 subependymal glioma 10.3 MUC1 VIM
40 short-rib thoracic dysplasia 12 10.3 MUC1 VIM
41 pleural empyema 10.3 MUC1 S100B
42 ovarian mucinous adenocarcinoma 10.3 MUC1 VIM
43 extraskeletal mesenchymal chondrosarcoma 10.3 MUC1 VIM
44 spondyloepimetaphyseal dysplasia, isidor type 10.3 MUC1 VIM
45 pancreatic ductal carcinoma 10.3 MUC1 VIM
46 secondary syphilis 10.3 MUC1 VIM
47 mesenchymoma 10.3 MUC1 VIM
48 spastic ataxia 3 10.3 MUC1 VIM
49 neutrophil immunodeficiency syndrome 10.3 S100B VIM
50 strabismus 10.2 MUC1 S100B

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma

Symptoms & Phenotypes for Eccrine Porocarcinoma

Drugs & Therapeutics for Eccrine Porocarcinoma

Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulins Phase 2
3 Antibodies, Monoclonal Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

Anatomical Context for Eccrine Porocarcinoma

MalaCards organs/tissues related to Eccrine Porocarcinoma:

39
Skin, Lymph Node, Colon, Lung

Publications for Eccrine Porocarcinoma

Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 140)
id Title Authors Year
1
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. ( 28831427 )
2017
2
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. ( 28087039 )
2017
3
Subungual Eccrine Porocarcinoma: Rare but Possible. ( 28328706 )
2017
4
Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases. ( 28110827 )
2017
5
Giant eccrine porocarcinoma in an unusual location. ( 28928336 )
2017
6
Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report. ( 27085107 )
2016
7
Eccrine porocarcinoma of the vulva: a case report and review of the literature. ( 27832810 )
2016
8
Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature. ( 26894080 )
2016
9
Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment. ( 27721767 )
2016
10
Eccrine Porocarcinoma Presenting as a Hand Cyst. ( 27593487 )
2016
11
Eccrine porocarcinoma mimicking a venous leg ulcer. ( 26400442 )
2015
12
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. ( 25515648 )
2015
13
Eccrine porocarcinoma of the thumb in a patient with chronic exposure to benzene glue. ( 26078532 )
2015
14
Eccrine porocarcinoma: A wolf in sheep's clothing. ( 25803156 )
2015
15
Eccrine Porocarcinoma of Scalp: a Rare Case Report. ( 26516328 )
2015
16
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. ( 26333057 )
2015
17
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015
18
Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. ( 25742554 )
2015
19
In-transit metastasis of advanced eccrine porocarcinoma. ( 26234455 )
2015
20
Metastatic eccrine porocarcinoma successfully treated with carboplatin and epirubicin chemotherapy. ( 26073009 )
2015
21
Eccrine porocarcinoma with extensive cutaneous metastases. ( 26566927 )
2015
22
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. ( 26205087 )
2015
23
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. ( 25984905 )
2015
24
Response to taxane-based chemotherapy in metastatic eccrine porocarcinoma with extensive cutaneous involvement. ( 26837980 )
2015
25
Intralesional Photodynamic Therapy for Eccrine Porocarcinoma. ( 26079590 )
2015
26
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. ( 24803063 )
2014
27
Rapidly growing eccrine porocarcinoma of the face in a pregnant woman. ( 24621740 )
2014
28
Eccrine porocarcinoma: a report of 2 cases and review of the literature. ( 24505584 )
2014
29
Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrheic Keratoses. ( 24909550 )
2014
30
Eccrine Porocarcinoma of the Eyelid in a Non-Caucasian Patient. ( 24841732 )
2014
31
A Rare Case of Eccrine Porocarcinoma of the Eyelid. ( 24576261 )
2014
32
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. ( 25076888 )
2014
33
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. ( 23773127 )
2013
34
Eccrine porocarcinoma: a case report. ( 24551693 )
2013
35
Eccrine porocarcinoma: clinical and pathological report of eight cases. ( 24403888 )
2013
36
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. ( 24003279 )
2013
37
Successful management of metastatic eccrine porocarcinoma. ( 24282649 )
2013
38
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). ( 24016659 )
2013
39
Metastatic eccrine porocarcinoma. ( 24087778 )
2013
40
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. ( 23917787 )
2013
41
Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report. ( 22689795 )
2012
42
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. ( 22108500 )
2012
43
Eccrine porocarcinoma arising within an area of Bowen disease. ( 21973218 )
2012
44
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. ( 22150617 )
2012
45
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. ( 22693407 )
2011
46
Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. ( 21711331 )
2011
47
Eccrine porocarcinoma of the vulva: a case report and review of literature. ( 21131825 )
2011
48
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. ( 21859481 )
2011
49
Metastatic eccrine porocarcinoma: report of a case and review of the literature. ( 21410982 )
2011
50
Primary eccrine porocarcinoma of the finger with transit forearm and axillary metastasis. ( 21042176 )
2011

Variations for Eccrine Porocarcinoma

Cosmic variations for Eccrine Porocarcinoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM17602 PTCH1 skin,hand,carcinoma,NS c.1922C>T p.P641L 4
2 COSM17596 PTCH1 skin,hand,carcinoma,NS c.863G>A p.G288D 4
3 COSM17597 PTCH1 skin,hand,carcinoma,NS c.1977G>A p.Q659Q 4
4 COSM521 KRAS skin,hand,carcinoma,NS c.35G>A p.G12D 4

Expression for Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for Eccrine Porocarcinoma

Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.26 LRIG1 STAT3 VIM
2 11.06 S100B VIM
3 10.86 MUC1 STAT3 VIM

GO Terms for Eccrine Porocarcinoma

Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT1 KRT15 VIM

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 movement of cell or subcellular component GO:0006928 8.96 STAT3 VIM
2 astrocyte differentiation GO:0048708 8.62 S100B STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT15 VIM

Sources for Eccrine Porocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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