MCID: ECC004
MIFTS: 44

Eccrine Porocarcinoma malady

Skin category

Summaries for Eccrine Porocarcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A malignant acrospiroma (also known as \"Malignant poroma,\" \"Porocarcinoma\", and... more...

MalaCards: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to squamous cell carcinoma and vulvar eccrine porocarcinoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are TGF-beta Receptor Signaling Pathway and Apoptosis Modulation and Signaling. The compounds vincristine and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung, and related mouse phenotypes are embryogenesis and vision/eye.

Aliases & Classifications for Eccrine Porocarcinoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

eccrine porocarcinoma 8 45 61
eccrine porocarcinoma of skin 8
malignant eccrine poroma 8
porocarcinoma 8


External Ids:

Disease Ontology8 DOID:7566
MeSH35 D057090
NCIt40 C5560

Related Diseases for Eccrine Porocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.5STAT3, MUC1, CDKN2A, KRT1, TP73, TP53
2vulvar eccrine porocarcinoma10.5
3lymphangitis10.4
4epidermal nevus10.3
5basaloid squamous cell carcinoma10.2
6erysipeloid10.2
7basal cell carcinoma10.2
8acrospiroma10.2
9paget disease, extramammary10.2
10angiosarcoma10.0MUC1
11rhabdoid tumor10.0MUC1
12leukoplakia10.0KRT1
13wilms tumor10.0TP73
14keratosis10.0KRT1
15pilocytic astrocytoma10.0TP73
16lichen planus10.0KRT1
17gastritis10.0TP53
18gallbladder cancer10.0TP53
19laryngeal carcinoma10.0TP53
20neuroblastoma10.0TP53
21actinic keratosis10.0TP53
22lynch syndrome10.0TP53
23rhabdomyosarcoma10.0TP53
24chondrosarcoma10.0MUC1
25ductal carcinoma in situ10.0TP53
26plasma cell leukemia10.0TP73
27xeroderma pigmentosum10.0TP53
28liposarcoma10.0TP53
29ulcerative colitis10.0TP53
30gastrointestinal stromal tumor10.0STAT3
31dermatofibrosarcoma protuberans10.0MUC1
32choroid plexus papilloma10.0TP53
33fibrosarcoma10.0STAT3
34myeloma10.0STAT3
35mycosis fungoides10.0STAT3
36benign mesothelioma10.0TP53
37hepatitis b10.0STAT3
38inflammatory bowel disease10.0STAT3
39arthritis10.0STAT3
40chordoma10.0KRT1, MUC1
41ischemia10.0ATF2
42ependymoma10.0MUC1, TP73
43epithelioid sarcoma10.0MUC1, KRT1
44neurofibroma10.0TP73, MUC1
45hemangioblastoma10.0MUC1
46amelanotic melanoma10.0
47skin amelanotic melanoma10.0
48malignant acrospiroma10.0
49syringoma10.0KRT1, MUC1
50sarcoma10.0TP53, MUC1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Clinical Features for Eccrine Porocarcinoma

Drugs & Therapeutics for Eccrine Porocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eccrine Porocarcinoma

Drug clinical trials:

Search ClinicalTrials for Eccrine Porocarcinoma

Search NIH Clinical Center for Eccrine Porocarcinoma

Search CenterWatch for Eccrine Porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

Anatomical Context for Eccrine Porocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Eccrine Porocarcinoma:

33
Skin, Lymph node, Lung, Colon

Animal Models for Eccrine Porocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Eccrine Porocarcinoma

Sources:
51PubMed
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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. (24003279)
2013
2
Successful management of metastatic eccrine porocarcinoma. (24282649)
2013
3
Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report. (22689795)
2012
4
Eccrine porocarcinoma of the vulva: a case report and review of literature. (21131825)
2011
5
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. (21859481)
2011
6
Primary eccrine porocarcinoma of the finger with transit forearm and axillary metastasis. (21042176)
2011
7
Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. (21711331)
2011
8
Metastatic eccrine porocarcinoma: report of a case and review of the literature. (21410982)
2011
9
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. (20976127)
2010
10
Recurrent pigmented eccrine porocarcinoma presenting as carcinoma erysipeloides. (19747328)
2009
11
Rectal and gynecologic amputation for a giant eccrine porocarcinoma of the pelvic floor. (19350871)
2009
12
Eccrine porocarcinoma of the auricle: a case report. (19605333)
2009
13
Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma. (17869487)
2008
14
Interesting response to concurrent chemoradiation in metastatic eccrine porocarcinoma. (18837710)
2008
15
Eccrine porocarcinoma: a rare but sometimes fatal malignant neoplasm. (17338701)
2007
16
Metastatic eccrine porocarcinoma detected on FDG PET/CT. (17710036)
2007
17
Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. (17004985)
2007
18
Eccrine porocarcinoma: clinical and pathological studies of 12 cases. (17683381)
2007
19
A case of metastatic eccrine porocarcinoma. (17989901)
2007
20
Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature. (17214856)
2007
21
Eccrine porocarcinoma of the face involving eyelids: a rare case report. (17294909)
2006
22
Eccrine porocarcinoma arising from preexisting eccrine poroma of the scalp after radiotherapy for cervical cancer. (17083898)
2006
23
Eccrine porocarcinoma. (16638385)
2006
24
Eccrine porocarcinoma of the nose: case report and review of world literature. (16490882)
2006
25
Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery. (16445507)
2006
26
Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma. (16815204)
2006
27
Eccrine porocarcinoma: a case report. (16612934)
2006
28
Eccrine porocarcinoma of the upper eyelid. (16197432)
2005
29
Eccrine porocarcinoma of the scrotum. (16011821)
2005
30
Eccrine porocarcinoma and eccrine poroma arising in a scar. (15214932)
2004
31
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. (15206695)
2004
32
Widespread metastatic eccrine porocarcinoma. (14576644)
2003
33
Aberrant expression of p16 and RB protein in eccrine porocarcinoma. (12207741)
2002
34
Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. (11332156)
2001
35
Eccrine porocarcinoma in a child that evolved rapidly from an eccrine poroma. (11568910)
2001
36
A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: biological characterization and clinical aggressiveness. (11053985)
2000
37
Intracranial extension of an eccrine porocarcinoma. Case report and review of the literature. (10413167)
1999
38
Eccrine porocarcinoma. (9236878)
1997
39
Metastasizing eccrine porocarcinoma: report of a case and review of the literature. (8912607)
1996
40
Eccrine porocarcinoma. (8828278)
1996
41
Vulvar eccrine porocarcinoma. (8812539)
1996
42
Periungual eccrine porocarcinoma. (8391881)
1993
43
Eccrine porocarcinoma. A review of 24 cases]. (8338322)
1993
44
A unique case of extramammary Paget's disease. Derivation from eccrine porocarcinoma? (1335216)
1992
45
Eccrine porocarcinoma of the face. (1325487)
1992
46
Epidermotropic eccrine porocarcinoma. (1999525)
1991
47
Metastasizing eccrine porocarcinoma developing in a sebaceous nevus of Jadassohn. Report of a case. (2983619)
1985
48
Eccrine porocarcinoma. Ultrastructural and immunological study. (6092444)
1984
49
Loss of membrane B2 microglobulin in eccrine porocarcinoma. Its association with the histopathologic and clinical criteria of malignancy. (6326692)
1984
50
Eccrine porocarcinoma: a case report with light microscopy and ultrastructure. (6296749)
1982

Genetic Variations for Eccrine Porocarcinoma

Expression for genes affiliated with Eccrine Porocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for genes affiliated with Eccrine Porocarcinoma

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 56SinoBiological, 30KEGG, 54Reactome
See all sources

Pathways related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP73, ATF2
2
Hide members
9.2TP73, TP53
39.1TP53, ATF2
4
Signal transduction JNK pathway
Hide members
9.1ATF2, TP53
59.0CDKN2A, TP53
69.0TP53, CDKN2A
7
Transcription P53 signaling pathway
Hide members
9.0TP53, CDKN2A
8
Hide members
8.9ATF2, KRT1, CDKN2A
98.8STAT3, TP53, MUC1
10
Hide members
8.7TP53, TP73, STAT3
118.7TP53, TP73, ATF2
128.6ATF2, STAT3, TP53
13
Hide members
8.6STAT3, TP53, ATF2
14
Hide members
8.6ATF2, STAT3, TP53
15
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
8.6TP53, ATF2, STAT3
16
Hide members
8.6CDKN2A, TP73, TP53
178.6CDKN2A, TP73, TP53
18
Hide members
8.6TP73, CDKN2A, TP53
198.5STAT3, TP53, CDKN2A
20
Hide members
8.5STAT3, TP53, CDKN2A
218.5CDKN2A, STAT3, TP53
228.5TP53, ATF2, CDKN2A
23
Hide members
8.2TP73, ATF2, STAT3, TP53
248.0STAT3, ATF2, CDKN2A, TP53
25
Hide members
7.6ATF2, MUC1, STAT3, CDKN2A, TP53

Compounds for genes affiliated with Eccrine Porocarcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1vincristine45 50 1112.4TP73
2butyrate4510.4ATF2
3serine4510.0STAT3, KRT1
4[alcl]459.8MUC1, STAT3
5hematoxylin459.5KRT1, MUC1, CDKN2A
6biotin45 11 2411.4CDKN2A, KRT1, MUC1
7acnu459.4TP53, CDKN2A
8hpvs459.3TP53, CDKN2A
95-methylcytosine45 2410.3TP53, CDKN2A
10olomoucine45 1110.3CDKN2A, TP53
11chloramphenicol45 2 1111.3TP73, CDKN2A, MUC1
12temozolomide45 1110.2CDKN2A, TP53
13agar459.2STAT3, CDKN2A, MUC1
14gemcitabine45 50 1111.2TP53, TP73, MUC1
15aflatoxin b145 2410.2TP53, CDKN2A
16paraffin459.2KRT1, STAT3, MUC1, TP73
17bcnu459.1TP53, CDKN2A
18parthenolide45 210.1TP53, STAT3
19noxa459.1TP53, TP73
20crcs459.1TP53, MUC1, CDKN2A
2112-o-tetradecanoylphorbol 13-acetate459.1MUC1, ATF2, STAT3, KRT1
22cytarabine45 50 1111.0CDKN2A, TP53, MUC1
23o6-methylguanine459.0CDKN2A, TP53, TP73
24sp 60012545 6010.0STAT3, TP53, ATF2
25retinoid458.9TP53, KRT1, STAT3
26camptothecin45 60 1110.9TP53, CDKN2A, TP73
27roscovitine458.9STAT3, CDKN2A, TP53
28paclitaxel45 50 1110.9STAT3, TP53, CDKN2A
29flavopiridol45 119.9CDKN2A, STAT3, TP53
30testosterone45 60 11 2411.9CDKN2A, STAT3, KRT1, MUC1
31docetaxel45 50 60 1111.9STAT3, CDKN2A, TP53
32mg 13245 609.8STAT3, CDKN2A, TP53
33arsenite45 249.8TP53, CDKN2A, STAT3
34adriamycin458.6TP73, CDKN2A, TP53, MUC1
35sb 20358045 609.6TP53, ATF2, STAT3
36n acetylcysteine458.6TP53, CDKN2A, STAT3
375-aza-2deoxycytidine458.5STAT3, TP73, CDKN2A, TP53
38tyrosine458.5ATF2, TP73, KRT1, STAT3, MUC1
39tamoxifen45 50 29 1111.5STAT3, MUC1, TP53
40h2o2458.3CDKN2A, STAT3, ATF2, TP53
41progesterone45 60 29 11 2412.2TP53, TP73, CDKN2A, MUC1, KRT1
425fluorouracil458.1CDKN2A, TP73, MUC1, STAT3, TP53
43actinomycin d458.1MUC1, TP53, STAT3, CDKN2A, TP73
44vegf458.1TP73, CDKN2A, MUC1, STAT3, TP53
45arginine458.1TP53, STAT3, CDKN2A, KRT1, TP73
46threonine458.0STAT3, TP73, MUC1, ATF2, KRT1, CDKN2A
47doxorubicin45 50 1110.0TP53, TP73, STAT3, ATF2, CDKN2A
48oligonucleotide458.0TP73, STAT3, TP53, ATF2, CDKN2A
49cisplatin45 50 60 1110.6TP53, TP73, CDKN2A, MUC1, ATF2, STAT3
50retinoic acid45 248.2MUC1, STAT3, ATF2, CDKN2A, KRT1, TP73

GO Terms for genes affiliated with Eccrine Porocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.7TP53, CDKN2A
2nucleoplasmGO:0056548.0TP53, CDKN2A, ATF2, STAT3

Biological processes related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.5TP73, TP53
2response to X-rayGO:0101659.3TP73, TP53
3release of cytochrome c from mitochondriaGO:0018369.3TP73, TP53
4replicative senescenceGO:0903999.3CDKN2A, TP53
5positive regulation of cell cycle arrestGO:0711589.2CDKN2A, TP53
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.2TP73, TP53
7cellular response to UVGO:0346449.2TP73, TP53
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.1TP73, MUC1, TP53
9response to gamma radiationGO:0103329.1TP53, TP73
10protein tetramerizationGO:0512628.9TP73, TP53
11response to DNA damage stimulusGO:0069748.9ATF2, TP53, TP73
12cell cycle arrestGO:0070508.8TP53, TP73, CDKN2A
13positive regulation of transcription, DNA-dependentGO:0458938.3STAT3, TP53, TP73, CDKN2A
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.2TP53, CDKN2A, STAT3, TP73

Molecular functions related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:0036849.2TP53, TP73
2MDM2/MDM4 family protein bindingGO:0973719.1TP53, CDKN2A
3transcription regulatory region DNA bindingGO:0442128.7STAT3, TP73, TP53
4p53 bindingGO:0020398.4TP53, TP73, CDKN2A, MUC1
5chromatin bindingGO:0036828.4TP73, TP53, ATF2
6transcription factor bindingGO:0081348.2STAT3, CDKN2A, TP73, TP53
7sequence-specific DNA binding transcription factor activityGO:0037008.1STAT3, TP53, TP73, ATF2
8protein kinase bindingGO:0199017.7TP53, TP73, CDKN2A, ATF2, STAT3
9protein bindingGO:0055156.7KRT1, MUC1, TP53, CDKN2A, TP73, STAT3

Products for genes affiliated with Eccrine Porocarcinoma

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Sources for Eccrine Porocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet