MCID: ECC004
MIFTS: 38

Eccrine Porocarcinoma

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Eccrine Porocarcinoma

MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 49 51 41 14 69
Eccrine Porocarcinoma of Skin 12 49
Malignant Eccrine Poroma 12 49
Porocarcinoma 12 49

Classifications:



External Ids:

Disease Ontology 12 DOID:7566
MeSH 41 D057090
NCIt 46 C5560
SNOMED-CT 64 128685001 254708001
UMLS 69 C1266065

Summaries for Eccrine Porocarcinoma

NIH Rare Diseases : 49 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. Treatment usually involves surgery to remove the tumor. Last updated: 12/13/2016

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to vulvar eccrine porocarcinoma and hydromyelia. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. The drugs nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and colon.

Related Diseases for Eccrine Porocarcinoma

Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 vulvar eccrine porocarcinoma 12.3
2 hydromyelia 10.4 S100B VIM
3 bednar tumor 10.4 S100B VIM
4 primary hepatic neuroendocrine carcinoma 10.4 S100B VIM
5 angiocentric glioma 10.3 S100B VIM
6 juvenile xanthogranuloma 10.3 S100B VIM
7 cutaneous fibrous histiocytoma 10.3 S100B VIM
8 adenoid squamous cell carcinoma 10.3 KRT7 VIM
9 odontogenic myxoma 10.3 S100B VIM
10 granular cell tumor 10.3 S100B VIM
11 papillary adenoma 10.3 KRT7 VIM
12 benign metastasizing leiomyoma 10.3 KRT7 VIM
13 embryonal sarcoma 10.3 S100B VIM
14 medulloepithelioma 10.3 KRT7 VIM
15 metanephric adenoma 10.3 KRT7 VIM
16 adenomatoid tumor 10.3 KRT7 VIM
17 fibrolamellar carcinoma 10.3 KRT7 VIM
18 endocervical adenocarcinoma 10.3 KRT7 VIM
19 osteochondroma 10.3 S100B VIM
20 endodermal sinus tumor 10.3 KRT7 VIM
21 collecting duct carcinoma 10.3 KRT7 VIM
22 granulosa cell tumor of the ovary 10.2 KRT7 VIM
23 malignant peritoneal mesothelioma 10.2 MUC1 VIM
24 papillary tumor of the pineal region 10.2 MUC1 VIM
25 biphasic synovial sarcoma 10.2 MUC1 VIM
26 clear cell meningioma 10.2 MUC1 VIM
27 squamous cell carcinoma 10.2
28 bowen's disease 10.2
29 myoepithelioma 10.2 S100B VIM
30 endometrial mucinous adenocarcinoma 10.2 MUC1 VIM
31 adenofibroma 10.2 MUC1 VIM
32 sarcomatoid mesothelioma 10.2 MUC1 VIM
33 perivascular epithelioid cell tumor 10.2 MUC1 VIM
34 reticulum cell sarcoma 10.2 MUC1 VIM
35 sertoli cell tumor 10.2 MUC1 VIM
36 chondroid chordoma 10.2 MUC1 VIM
37 neurilemmoma 10.2 S100B VIM
38 mesenchymal chondrosarcoma 10.2 MUC1 VIM
39 extraskeletal ewing sarcoma 10.2 MUC1 VIM
40 localized hypertrophic neuropathy 10.2 MUC1 S100B
41 sclerosing perineurioma 10.2 MUC1 S100B
42 filamentary keratitis 10.2 KRT1 MUC1
43 intracranial cysts 10.2 MUC1 S100B
44 reticular perineurioma 10.2 MUC1 S100B
45 non-functioning pituitary adenoma 10.2 MUC1 S100B
46 epithelioid malignant peripheral nerve sheath tumor 10.2 MUC1 S100B
47 myxofibrosarcoma 10.2 MUC1 S100B
48 white sponge nevus 1 10.2 KRT1 KRT7
49 aggressive digital papillary adenocarcinoma 10.2 MUC1 S100B
50 chordoid glioma 10.2 MUC1 S100B

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma

Symptoms & Phenotypes for Eccrine Porocarcinoma

Drugs & Therapeutics for Eccrine Porocarcinoma

Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

Anatomical Context for Eccrine Porocarcinoma

MalaCards organs/tissues related to Eccrine Porocarcinoma:

38
Skin, Lymph Node, Colon, Lung

Publications for Eccrine Porocarcinoma

Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 143)
# Title Authors Year
1
Eccrine porocarcinoma arising from the knee. ( 29445476 )
2018
2
A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report. ( 29245095 )
2018
3
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. ( 28087039 )
2017
4
Giant eccrine porocarcinoma in an unusual location. ( 28928336 )
2017
5
Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases. ( 28110827 )
2017
6
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. ( 28831427 )
2017
7
Cytodiagnosis of Eccrine Porocarcinoma of the Scalp. ( 29118525 )
2017
8
Subungual Eccrine Porocarcinoma: Rare but Possible. ( 28328706 )
2017
9
Eccrine Porocarcinoma Presenting as a Hand Cyst. ( 27593487 )
2016
10
Eccrine porocarcinoma of the vulva: a case report and review of the literature. ( 27832810 )
2016
11
Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment. ( 27721767 )
2016
12
Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report. ( 27085107 )
2016
13
Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature. ( 26894080 )
2016
14
Eccrine porocarcinoma with extensive cutaneous metastases. ( 26566927 )
2015
15
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. ( 25984905 )
2015
16
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. ( 25515648 )
2015
17
Intralesional Photodynamic Therapy for Eccrine Porocarcinoma. ( 26079590 )
2015
18
Eccrine porocarcinoma mimicking a venous leg ulcer. ( 26400442 )
2015
19
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015
20
Eccrine porocarcinoma of the thumb in a patient with chronic exposure to benzene glue. ( 26078532 )
2015
21
Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. ( 25742554 )
2015
22
Eccrine Porocarcinoma of Scalp: a Rare Case Report. ( 26516328 )
2015
23
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. ( 26205087 )
2015
24
Metastatic eccrine porocarcinoma successfully treated with carboplatin and epirubicin chemotherapy. ( 26073009 )
2015
25
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. ( 26333057 )
2015
26
Response to taxane-based chemotherapy in metastatic eccrine porocarcinoma with extensive cutaneous involvement. ( 26837980 )
2015
27
In-transit metastasis of advanced eccrine porocarcinoma. ( 26234455 )
2015
28
Eccrine porocarcinoma: A wolf in sheep's clothing. ( 25803156 )
2015
29
Eccrine Porocarcinoma of the Eyelid in a Non-Caucasian Patient. ( 24841732 )
2014
30
Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrheic Keratoses. ( 24909550 )
2014
31
Eccrine porocarcinoma: a report of 2 cases and review of the literature. ( 24505584 )
2014
32
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. ( 25076888 )
2014
33
A Rare Case of Eccrine Porocarcinoma of the Eyelid. ( 24576261 )
2014
34
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. ( 24803063 )
2014
35
Rapidly growing eccrine porocarcinoma of the face in a pregnant woman. ( 24621740 )
2014
36
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. ( 23917787 )
2013
37
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). ( 24016659 )
2013
38
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. ( 23773127 )
2013
39
Metastatic eccrine porocarcinoma. ( 24087778 )
2013
40
Eccrine porocarcinoma: a case report. ( 24551693 )
2013
41
Eccrine porocarcinoma: clinical and pathological report of eight cases. ( 24403888 )
2013
42
Successful management of metastatic eccrine porocarcinoma. ( 24282649 )
2013
43
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. ( 24003279 )
2013
44
Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report. ( 22689795 )
2012
45
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. ( 22150617 )
2012
46
Eccrine porocarcinoma arising within an area of Bowen disease. ( 21973218 )
2012
47
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. ( 22108500 )
2012
48
Eccrine porocarcinoma of the external ear. ( 21853429 )
2011
49
Metastatic eccrine porocarcinoma: report of a case and review of the literature. ( 21410982 )
2011
50
Eccrine porocarcinoma of the vulva: a case report and review of literature. ( 21131825 )
2011

Variations for Eccrine Porocarcinoma

Expression for Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for Eccrine Porocarcinoma

Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 KRT7 MUC1 VIM
2
Show member pathways
11.79 KRT1 KRT15 KRT7
3 11.19 MUC1 STAT3 VIM
4
Show member pathways
10.83 KRT1 KRT7 VIM

GO Terms for Eccrine Porocarcinoma

Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 KRT1 KRT15 KRT7 VIM

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.33 KRT1 KRT15 KRT7
2 cornification GO:0070268 9.13 KRT1 KRT15 KRT7
3 astrocyte differentiation GO:0048708 8.62 S100B STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT15 VIM
2 structural molecule activity GO:0005198 8.8 KRT1 KRT7 VIM

Sources for Eccrine Porocarcinoma

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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32 ICD10
33 ICD10 via Orphanet
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42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
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54 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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