MCID: ECC004
MIFTS: 49

Eccrine Porocarcinoma malady

Skin diseases category

Summaries for Eccrine Porocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A malignant acrospiroma (also known as \"Malignant poroma,\" \"Porocarcinoma\", and... more...

MalaCards: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to keratosis and squamous cell carcinoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are TGF-beta Receptor Signaling Pathway and Apoptosis Modulation and Signaling. The compounds vincristine and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and colon, and related mouse phenotypes are embryogenesis and vision/eye.

Aliases & Classifications for Eccrine Porocarcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

eccrine porocarcinoma 8 44 60
eccrine porocarcinoma of skin 8
malignant eccrine poroma 8
porocarcinoma 8


External Ids:

Disease Ontology8 DOID:7566
MeSH34 D057090
NCIt39 C5560

Related Diseases for Eccrine Porocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis30.5KRT1
2squamous cell carcinoma30.4STAT3, MUC1, CDKN2A, KRT1, TP73, TP53
3cervical cancer30.2TP53, KRT1, CDKN2A
4retinoblastoma30.2STAT3, ATF2, CDKN2A, TP73, TP53
5melanoma30.2STAT3, ATF2, CDKN2A, TP73, TP53
6vulvar eccrine porocarcinoma10.5
7lymphangitis10.3
8basaloid squamous cell carcinoma10.2
9erysipeloid10.2
10cervicitis10.2
11lymphedema10.2
12seborrheic keratosis10.2
13acrospiroma10.2
14angiosarcoma10.0MUC1
15rhabdoid tumor10.0MUC1
16leukoplakia10.0KRT1
17wilms tumor10.0TP73
18pilocytic astrocytoma10.0TP73
19lichen planus10.0KRT1
20gastritis10.0TP53
21gallbladder cancer10.0TP53
22laryngeal benign neoplasm10.0TP53
23neuroblastoma10.0TP53
24actinic keratosis10.0TP53
25lynch syndrome10.0TP53
26rhabdomyosarcoma10.0TP53
27chondrosarcoma10.0MUC1
28ductal carcinoma in situ10.0TP53
29plasma cell leukemia10.0TP73
30xeroderma pigmentosum10.0TP53
31liposarcoma10.0TP53
32ulcerative colitis10.0TP53
33gastrointestinal stromal tumor10.0STAT3
34dermatofibrosarcoma protuberans10.0MUC1
35choroid plexus papilloma10.0TP53
36fibrosarcoma10.0STAT3
37myeloma10.0STAT3
38mycosis fungoides10.0STAT3
39benign mesothelioma10.0TP53
40hepatitis b10.0STAT3
41inflammatory bowel disease10.0STAT3
42arthritis10.0STAT3
43chordoma10.0KRT1, MUC1
44ischemia10.0ATF2
45ependymoma10.0MUC1, TP73
46epithelioid sarcoma10.0MUC1, KRT1
47neurofibroma10.0TP73, MUC1
48hemangioblastoma10.0MUC1
49syringoma10.0KRT1, MUC1
50sarcoma10.0TP53, MUC1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Clinical Features for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Eccrine Porocarcinoma:

32
Skin, Lymph node, Colon, Lung

Animal Models for Eccrine Porocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.0ATF2
2MP:00053919.8ATF2, MUC1
3MP:00053769.8ATF2, KRT1
4MP:00053909.5STAT3, ATF2
5MP:00107718.3TP53, KRT1, CDKN2A, STAT3
6MP:00053888.3STAT3, ATF2, TP73, TP53
7MP:00030128.2TP53, KRT1, CDKN2A, MUC1
8MP:00053798.2TP53, TP73, CDKN2A, STAT3
9MP:00053817.8STAT3, MUC1, CDKN2A, TP73, TP53
10MP:00053707.8TP53, CDKN2A, MUC1, ATF2, STAT3
11MP:00020067.4TP53, TP73, CDKN2A, MUC1, ATF2, STAT3
12MP:00053977.2STAT3, ATF2, CDKN2A, TP73, TP53
13MP:00107687.0STAT3, ATF2, CDKN2A, KRT1, TP73, TP53

Publications for Eccrine Porocarcinoma

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50PubMed
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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Eccrine porocarcinoma: clinical and pathological report of eight cases. (24403888)
2013
2
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. (23917787)
2013
3
Metastatic eccrine porocarcinoma. (24087778)
2013
4
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). (24016659)
2013
5
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. (22108500)
2012
6
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. (22150617)
2012
7
Eccrine porocarcinoma arising within an area of Bowen disease. (21973218)
2012
8
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. (22693407)
2011
9
Eccrine porocarcinoma of the external ear. (21853429)
2011
10
Aggressive eccrine porocarcinoma associated with haematological disorders: report of two cases. (20518919)
2010
11
A case of clear cell eccrine porocarcinoma. (20711273)
2010
12
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report. (20492705)
2010
13
Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases. (20668633)
2010
14
Eccrine porocarcinoma presenting with scrotal lymphedema: a case report and review of systemic treatment. (20089564)
2010
15
Fine-needle aspiration cytology of metastatic eccrine porocarcinoma. (19405111)
2009
16
Significance of cyclin D1-, product of retinoblastoma (pRb), p53, p63 and p73 expression in eccrine poroma and eccrine porocarcinoma. (19643581)
2009
17
Eccrine porocarcinoma. (19076620)
2008
18
The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases. (17704263)
2008
19
Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma. (17869487)
2008
20
Eccrine porocarcinoma. (18474158)
2008
21
Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. (18182815)
2008
22
Metastatic eccrine porocarcinoma detected on FDG PET/CT. (17710036)
2007
23
Eccrine porocarcinoma: Report of a case with fine needle aspiration cytology, histopathology and immunohistochemistry. (16901019)
2006
24
Eccrine porocarcinoma of the nose: case report and review of world literature. (16490882)
2006
25
Eccrine porocarcinoma of the upper eyelid. (16197432)
2005
26
(18)F-fluorodeoxyglucose positron emission tomography detection of eccrine porocarcinoma. (15727659)
2005
27
Eccrine porocarcinoma (malignant eccrine poroma): a case report. (16150225)
2005
28
Eccrine porocarcinoma and Bowen's disease with fatal metastasis to the lung. (15455628)
2004
29
Eccrine porocarcinoma of the eyelid treated with Mohs micrographic surgery. (15056155)
2004
30
Eccrine porocarcinoma of the penis. (12544320)
2003
31
Metastatic eccrine porocarcinoma: a 5.6-year follow-up study of a patient treated with a combined therapeutic protocol. (14725669)
2003
32
Eccrine porocarcinoma: A case report and review of the literature. (24115860)
2003
33
Eccrine porocarcinoma arising in a seborrheic keratosis evaluated with dermoscopy and treated with Mohs' technique. (12890117)
2003
34
Eccrine porocarcinoma (malignant eccrine poroma). (11812953)
2002
35
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. (11395548)
2001
36
Eccrine porocarcinoma treated with Mohs micrographic surgery: A report of five cases. (10594609)
1999
37
Eccrine porocarcinoma: a case report. (10561775)
1999
38
Eccrine porocarcinoma with melanocyte colonization. (9580812)
1998
39
Eccrine porocarcinoma. Report of nine cases. (9357503)
1997
40
Eccrine porocarcinoma with intracerebral extension. (9204344)
1997
41
A case of multiple eccrine porocarcinoma with stepping-stone distribution on the foot. (7650246)
1995
42
Pigmented eccrine porocarcinoma: a mimic of malignant melanoma. (7557914)
1995
43
p53 protein and proliferating cell nuclear antigen in eccrine poroma and porocarcinoma. an immunohistochemical study. (8599450)
1995
44
A histopathological and ultrastructural study of eccrine porocarcinoma with special reference to its subtypes. (1317619)
1992
45
Metastasizing eccrine porocarcinoma. Report of two cases with fatal outcome. (1652130)
1991
46
A case of eccrine porocarcinoma. (2172536)
1990
47
Eccrine porocarcinoma. (2834991)
1988
48
Three cases of eccrine porocarcinoma. (3015186)
1986
49
Eccrine porocarcinoma: a case report with light microscopy and ultrastructure. (6296749)
1982
50
Eccrine porocarcinoma. (6256417)
1980

Genetic Variations for Eccrine Porocarcinoma

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Expression for genes affiliated with Eccrine Porocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for genes affiliated with Eccrine Porocarcinoma

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 29KEGG, 53Reactome
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Pathways related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ATF2, TP73
2
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9.2TP53, TP73
39.1ATF2, TP53
4
Signal transduction JNK pathway
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9.1TP53, ATF2
59.0TP53, CDKN2A
69.0TP53, CDKN2A
7
Transcription P53 signaling pathway
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9.0TP53, CDKN2A
8
Hide members
8.9ATF2, CDKN2A, KRT1
98.8TP53, MUC1, STAT3
10
Hide members
8.7TP53, TP73, STAT3
118.7ATF2, TP73, TP53
128.6STAT3, ATF2, TP53
13
Hide members
8.6TP53, ATF2, STAT3
14
Hide members
8.6TP53, ATF2, STAT3
15
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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8.6STAT3, ATF2, TP53
16
Hide members
8.6TP53, TP73, CDKN2A
178.6TP53, TP73, CDKN2A
18
Hide members
8.6CDKN2A, TP73, TP53
198.5TP53, CDKN2A, STAT3
20
Hide members
8.5TP53, CDKN2A, STAT3
218.5STAT3, CDKN2A, TP53
228.5TP53, CDKN2A, ATF2
23
Hide members
8.2STAT3, ATF2, TP73, TP53
248.0TP53, CDKN2A, ATF2, STAT3
25
Hide members
7.6STAT3, ATF2, MUC1, CDKN2A, TP53

Compounds for genes affiliated with Eccrine Porocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.4TP73
2butyrate4410.4ATF2
3serine4410.0STAT3, KRT1
4[alcl]449.8MUC1, STAT3
5hematoxylin449.5KRT1, MUC1, CDKN2A
6biotin44 11 2411.4CDKN2A, KRT1, MUC1
7acnu449.4TP53, CDKN2A
8hpvs449.3TP53, CDKN2A
95-methylcytosine44 2410.3TP53, CDKN2A
10olomoucine44 1110.3CDKN2A, TP53
11chloramphenicol44 2 1111.3TP73, CDKN2A, MUC1
12temozolomide44 1110.2CDKN2A, TP53
13agar449.2STAT3, CDKN2A, MUC1
14gemcitabine44 49 1111.2TP53, TP73, MUC1
15aflatoxin b144 2410.2TP53, CDKN2A
16paraffin449.2KRT1, STAT3, MUC1, TP73
17bcnu449.1TP53, CDKN2A
18parthenolide44 210.1TP53, STAT3
19noxa449.1TP53, TP73
20crcs449.1TP53, MUC1, CDKN2A
2112-o-tetradecanoylphorbol 13-acetate449.1MUC1, ATF2, STAT3, KRT1
22cytarabine44 49 1111.0CDKN2A, TP53, MUC1
23o6-methylguanine449.0CDKN2A, TP53, TP73
24sp 60012544 5910.0STAT3, TP53, ATF2
25retinoid448.9TP53, KRT1, STAT3
26camptothecin44 59 1110.9TP53, CDKN2A, TP73
27roscovitine448.9STAT3, CDKN2A, TP53
28paclitaxel44 49 1110.9STAT3, TP53, CDKN2A
29flavopiridol44 119.9CDKN2A, STAT3, TP53
30testosterone44 59 11 2411.9CDKN2A, STAT3, KRT1, MUC1
31docetaxel44 49 59 1111.9STAT3, CDKN2A, TP53
32mg 13244 599.8STAT3, CDKN2A, TP53
33arsenite44 249.8TP53, CDKN2A, STAT3
34adriamycin448.6TP73, CDKN2A, TP53, MUC1
35sb 20358044 599.6TP53, ATF2, STAT3
36n acetylcysteine448.6TP53, CDKN2A, STAT3
375-aza-2deoxycytidine448.5STAT3, TP73, CDKN2A, TP53
38tyrosine448.5ATF2, TP73, KRT1, STAT3, MUC1
39tamoxifen44 49 28 1111.5STAT3, MUC1, TP53
40h2o2448.3CDKN2A, STAT3, ATF2, TP53
41progesterone44 59 28 11 2412.2TP53, TP73, CDKN2A, MUC1, KRT1
425fluorouracil448.1CDKN2A, TP73, MUC1, STAT3, TP53
43actinomycin d448.1MUC1, TP53, STAT3, CDKN2A, TP73
44vegf448.1TP73, CDKN2A, MUC1, STAT3, TP53
45arginine448.1TP53, STAT3, CDKN2A, KRT1, TP73
46threonine448.0STAT3, TP73, MUC1, ATF2, KRT1, CDKN2A
47doxorubicin44 49 1110.0TP53, TP73, STAT3, ATF2, CDKN2A
48oligonucleotide448.0TP73, STAT3, TP53, ATF2, CDKN2A
49cisplatin44 49 59 1110.6TP53, TP73, CDKN2A, MUC1, ATF2, STAT3
50retinoic acid44 248.2MUC1, STAT3, ATF2, CDKN2A, KRT1, TP73

GO Terms for genes affiliated with Eccrine Porocarcinoma

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16Gene Ontology
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Cellular components related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.7TP53, CDKN2A
2nucleoplasmGO:0056548.0TP53, CDKN2A, ATF2, STAT3

Biological processes related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP73
2response to X-rayGO:0101659.3TP53, TP73
3release of cytochrome c from mitochondriaGO:0018369.3TP73, TP53
4replicative senescenceGO:0903999.3TP53, CDKN2A
5positive regulation of cell cycle arrestGO:0711589.2CDKN2A, TP53
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.2TP53, TP73
7cellular response to UVGO:0346449.2TP53, TP73
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.1TP53, TP73, MUC1
9response to gamma radiationGO:0103329.1TP53, TP73
10protein tetramerizationGO:0512628.9TP53, TP73
11response to DNA damage stimulusGO:0069748.9TP53, TP73, ATF2
12cell cycle arrestGO:0070508.8CDKN2A, TP73, TP53
13positive regulation of transcription, DNA-dependentGO:0458938.3STAT3, CDKN2A, TP73, TP53
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.2TP53, TP73, CDKN2A, STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:0036849.2TP53, TP73
2MDM2/MDM4 family protein bindingGO:0973719.1TP53, CDKN2A
3transcription regulatory region DNA bindingGO:0442128.7STAT3, TP73, TP53
4p53 bindingGO:0020398.4TP53, TP73, CDKN2A, MUC1
5chromatin bindingGO:0036828.4TP53, TP73, ATF2
6transcription factor bindingGO:0081348.2TP53, TP73, CDKN2A, STAT3
7sequence-specific DNA binding transcription factor activityGO:0037008.1STAT3, ATF2, TP73, TP53
8protein kinase bindingGO:0199017.7STAT3, ATF2, CDKN2A, TP73, TP53
9protein bindingGO:0055156.7STAT3, ATF2, MUC1, CDKN2A, KRT1, TP73

Products for genes affiliated with Eccrine Porocarcinoma

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Sources for Eccrine Porocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet