MCID: ECC004
MIFTS: 52

Eccrine Porocarcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Eccrine Porocarcinoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A malignant acrospiroma (also known as \"Malignant poroma,\" \"Porocarcinoma\", and... more...

MalaCards: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to cervical cancer and retinoblastoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are IL-5 Signaling Pathway and AGE/RAGE pathway. The compounds hematoxylin and biotin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and lymph node, and related mouse phenotypes are pigmentation and reproductive system.

Aliases & Classifications for Eccrine Porocarcinoma

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8Disease Ontology, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

eccrine porocarcinoma 8 45 62
eccrine porocarcinoma of skin 8
malignant eccrine poroma 8
porocarcinoma 8


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Disease Ontology8 DOID:7566
MeSH35 D057090
NCIt40 C5560

Related Diseases for Eccrine Porocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1cervical cancer30.3TP53, TP73, CDKN2A
2retinoblastoma30.1ATF2, TP53, TP73, STAT3, CDKN2A
3melanoma30.1ATF2, TP53, TP73, STAT3, CDKN2A
4vulvar eccrine porocarcinoma10.5
5lymphangitis10.4
6keratosis10.4
7epidermal nevus10.3
8basaloid squamous cell carcinoma10.2
9erysipeloid10.2
10cervicitis10.2
11lymphedema10.2
12seborrheic keratosis10.2
13acrospiroma10.2
14actinic keratosis10.1TP53
15choroid plexus papilloma10.1TP53
16kidney cancer10.1TP53
17syringoma10.1MUC1, KRT1
18epithelioid sarcoma10.1MUC1, KRT1
19chordoma10.1MUC1, KRT1
20neuroendocrine carcinoma10.1KRT1, MUC1
21synovial sarcoma10.1MUC1, KRT1
22malignant mixed mullerian tumor10.1MUC1, TP53
23neurofibroma10.1MUC1, TP73
24ependymoma10.1TP73, MUC1
25malignant peripheral nerve sheath tumor10.0CDKN2A, MUC1
26leiomyosarcoma10.0TP53, MUC1
27oropharyngeal cancer, adult10.0TP53, CDKN2A
28oligodendroglioma10.0CDKN2A, TP73
29li-fraumeni syndrome10.0TP53, CDKN2A
30nasopharynx carcinoma10.0TP53, CDKN2A
31cervical squamous cell carcinoma10.0CDKN2A, TP73
32cervical intraepithelial neoplasia10.0CDKN2A, TP73
33leukemia, acute lymphoblastic 310.0TP73, CDKN2A
34meningioma10.0TP73, MUC1, KRT1
35malignant mesothelioma10.0MUC1, CDKN2A
36barrett's esophagus10.0TP53, CDKN2A
37bladder carcinoma in situ10.0CDKN2A, TP53
38benign mesothelioma10.0CDKN2A, MUC1
39cholangiocarcinoma10.0TP53, MUC1
40esophageal cancer10.0CDKN2A, TP53
41skin benign neoplasm10.0STAT3, KRT1
42anaplastic large cell lymphoma10.0STAT3, MUC1
43bladder carcinoma10.0CDKN2A, TP53
44thyroid cancer10.0TP73, TP53
45lung small cell carcinoma10.0CDKN2A, MUC1, TP53
46lung cancer10.0TP53, MUC1, CDKN2A
47malignant acrospiroma10.0
48amelanotic melanoma10.0
49papillary thyroid carcinoma10.0KRT1, STAT3
50laryngeal squamous cell carcinoma10.0CDKN2A, TP73, TP53

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Symptoms for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Eccrine Porocarcinoma

Search NIH Clinical Center for Eccrine Porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Eccrine Porocarcinoma:

33
Skin, Lung, Lymph node, Colon

Animal Models for Eccrine Porocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7TP53, KRT1, CDKN2A
2MP:00053898.1CDKN2A, STAT3, TP73, TP53
3MP:00053818.0TP53, TP73, MUC1, STAT3, CDKN2A
4MP:00053707.9ATF2, TP53, MUC1, STAT3, CDKN2A
5MP:00053797.9TP53, TP73, MUC1, STAT3, CDKN2A
6MP:00028737.8ATF2, TP53, MUC1, STAT3
7MP:00053887.8ATF2, TP53, TP73, STAT3, CDKN2A
8MP:00053857.8ATF2, TP53, TP73, STAT3, KRT1
9MP:00053907.7ATF2, TP53, TP73, STAT3, CDKN2A
10MP:00053807.7ATF2, TP53, TP73, STAT3, CDKN2A
11MP:00053867.6CDKN2A, STAT3, TP73, TP53, ATF2
12MP:00107717.5ATF2, TP53, MUC1, STAT3, KRT1, CDKN2A
13MP:00020067.5CDKN2A, STAT3, MUC1, TP73, TP53, ATF2
14MP:00053917.5ATF2, TP53, TP73, MUC1, STAT3, CDKN2A
15MP:00053847.4CDKN2A, STAT3, TP73, TP53, ATF2
16MP:00053977.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
17MP:00053877.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
18MP:00036317.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
19MP:00053787.3ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
20MP:00107687.3ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
21MP:00053767.1ATF2, TP53, TP73, MUC1, STAT3, KRT1

Publications for Eccrine Porocarcinoma

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52PubMed
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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 105)
idTitleAuthorsYear
1
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. (24003279)
2013
2
Eccrine porocarcinoma: clinical and pathological report of eight cases. (24403888)
2013
3
Successful management of metastatic eccrine porocarcinoma. (24282649)
2013
4
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. (23773127)
2013
5
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. (23917787)
2013
6
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. (22108500)
2012
7
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. (22150617)
2012
8
Eccrine porocarcinoma of the vulva: a case report and review of literature. (21131825)
2011
9
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. (21859481)
2011
10
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. (22693407)
2011
11
Aggressive eccrine porocarcinoma associated with haematological disorders: report of two cases. (20518919)
2010
12
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. (20976127)
2010
13
A case of clear cell eccrine porocarcinoma. (20711273)
2010
14
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report. (20492705)
2010
15
Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases. (20668633)
2010
16
Recurrent pigmented eccrine porocarcinoma presenting as carcinoma erysipeloides. (19747328)
2009
17
Eccrine porocarcinoma. (19076620)
2008
18
Eccrine porocarcinoma of the upper eyelid. (18520840)
2008
19
Eccrine porocarcinoma: a rare but sometimes fatal malignant neoplasm. (17338701)
2007
20
Metastatic eccrine porocarcinoma detected on FDG PET/CT. (17710036)
2007
21
Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. (17004985)
2007
22
Eccrine porocarcinoma of the face involving eyelids: a rare case report. (17294909)
2006
23
Eccrine porocarcinoma arising from preexisting eccrine poroma of the scalp after radiotherapy for cervical cancer. (17083898)
2006
24
Eccrine porocarcinoma. (16638385)
2006
25
Eccrine porocarcinoma: Report of a case with fine needle aspiration cytology, histopathology and immunohistochemistry. (16901019)
2006
26
Eccrine porocarcinoma of the nose: case report and review of world literature. (16490882)
2006
27
Eccrine porocarcinoma of the upper eyelid. (16197432)
2005
28
Eccrine porocarcinoma and eccrine poroma arising in a scar. (15214932)
2004
29
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. (15206695)
2004
30
Eccrine porocarcinoma and Bowen's disease with fatal metastasis to the lung. (15455628)
2004
31
Eccrine porocarcinoma of the penis. (12544320)
2003
32
Metastatic eccrine porocarcinoma: a 5.6-year follow-up study of a patient treated with a combined therapeutic protocol. (14725669)
2003
33
Eccrine porocarcinoma: A case report and review of the literature. (24115860)
2003
34
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. (11395548)
2001
35
Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. (11332156)
2001
36
A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: biological characterization and clinical aggressiveness. (11053985)
2000
37
Eccrine porocarcinoma treated with Mohs micrographic surgery: A report of five cases. (10594609)
1999
38
Eccrine porocarcinoma: a case report. (10561775)
1999
39
Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient. (10491509)
1999
40
Eccrine porocarcinoma with melanocyte colonization. (9580812)
1998
41
Eccrine porocarcinoma. Report of nine cases. (9357503)
1997
42
Metastasizing eccrine porocarcinoma: report of a case and review of the literature. (8912607)
1996
43
Eccrine porocarcinoma. (8828278)
1996
44
A case of multiple eccrine porocarcinoma with stepping-stone distribution on the foot. (7650246)
1995
45
Eccrine porocarcinoma. (8159010)
1994
46
A unique case of extramammary Paget's disease. Derivation from eccrine porocarcinoma? (1335216)
1992
47
A histopathological and ultrastructural study of eccrine porocarcinoma with special reference to its subtypes. (1317619)
1992
48
Eccrine porocarcinoma of the face. (1325487)
1992
49
Eccrine porocarcinoma. (1653154)
1991
50
Eccrine porocarcinoma: a case report with light microscopy and ultrastructure. (6296749)
1982

Variations for Eccrine Porocarcinoma

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Expression for genes affiliated with Eccrine Porocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for genes affiliated with Eccrine Porocarcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 60Thomson Reuters, 55Reactome, 53QIAGEN, 61Tocris Bioscience, 30KEGG, 5Cell Signaling Technology, 57SinoBiological
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Pathways related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ATF2, STAT3
29.3STAT3, ATF2
3
Show member pathways
9.3STAT3, ATF2
4
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3STAT3, ATF2
5
Show member pathways
IFN-gamma pathway38
9.3STAT3, ATF2
6
Show member pathways
RAC1 signaling pathway38
9.3STAT3, ATF2
79.1CDKN2A, TP53
89.1CDKN2A, TP53
99.1CDKN2A, TP53
109.1TP53, CDKN2A
119.1CDKN2A, TP53
12
Show member pathways
9.1TP53, CDKN2A
139.1TP53, ATF2
149.1TP53, ATF2
15
Show member pathways
9.0STAT3, TP53
16
Show member pathways
9.0CDKN2A, KRT1, ATF2
17
Show member pathways
8.7CDKN2A, TP73, TP53
18
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.7TP53, TP73, CDKN2A
19
Show member pathways
DNA damage response38
8.7TP53, TP73, CDKN2A
20
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.7CDKN2A, TP73, TP53
21
Show member pathways
8.7TP53, TP73, CDKN2A
228.7TP73, TP53, ATF2
23
Show member pathways
ATM Signaling Pathway38
8.7ATF2, TP53, TP73
248.7TP53, MUC1, STAT3
258.6ATF2, TP53, CDKN2A
26
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.6TP53, TP73, STAT3
27
Show member pathways
8.5TP53, STAT3, CDKN2A
28
Show member pathways
8.5CDKN2A, STAT3, TP53
298.5TP53, STAT3, CDKN2A
308.5TP53, STAT3, CDKN2A
31
Show member pathways
8.5STAT3, TP53, ATF2
32
Show member pathways
8.5ATF2, TP53, STAT3
33
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
8.5ATF2, TP53, STAT3
34
Show member pathways
8.5ATF2, TP53, STAT3
35
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5STAT3, TP53, ATF2
36
Show member pathways
8.5STAT3, TP53, ATF2
378.5STAT3, TP53, ATF2
38
Show member pathways
8.1STAT3, TP73, TP53, ATF2
398.0CDKN2A, STAT3, TP53, ATF2
40
Show member pathways
8.0CDKN2A, STAT3, TP53, ATF2
41
Show member pathways
7.6CDKN2A, STAT3, MUC1, TP53, ATF2

Compounds for genes affiliated with Eccrine Porocarcinoma

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1hematoxylin459.6CDKN2A, KRT1, MUC1
2biotin45 24 1111.5MUC1, KRT1, CDKN2A
3[alcl]459.5MUC1, STAT3
4acnu459.5TP53, CDKN2A
5hpvs459.4TP53, CDKN2A
6chloramphenicol45 3 51 1112.3TP73, MUC1, CDKN2A
75-methylcytosine45 2410.3TP53, CDKN2A
8olomoucine45 1110.3TP53, CDKN2A
9gemcitabine45 51 1111.2TP53, TP73, MUC1
10temozolomide45 1110.2TP53, CDKN2A
11agar459.2CDKN2A, STAT3, MUC1
12crcs459.2CDKN2A, MUC1, TP53
13aflatoxin b145 2410.1CDKN2A, TP53
14cytarabine45 51 1111.1TP53, MUC1, CDKN2A
15o6-methylguanine459.1CDKN2A, TP73, TP53
16vincristine45 51 1111.0CDKN2A, TP73, TP53
17camptothecin45 61 1111.0CDKN2A, TP73, TP53
1812-o-tetradecanoylphorbol 13-acetate459.0KRT1, STAT3, MUC1, ATF2
19roscovitine458.9CDKN2A, STAT3, TP53
20flavopiridol45 119.9TP53, STAT3, CDKN2A
21sp 60012545 619.9STAT3, TP53, ATF2
22testosterone45 61 24 1111.8MUC1, STAT3, KRT1, CDKN2A
23docetaxel45 51 61 1111.8TP53, STAT3, CDKN2A
24hmba458.8CDKN2A, TP53
25egcg458.8CDKN2A, STAT3, TP53
26retinoid458.8KRT1, STAT3, TP53
27mg 13245 619.8CDKN2A, STAT3, TP53
28arsenite45 249.8TP53, STAT3, CDKN2A
29adriamycin458.7CDKN2A, MUC1, TP73, TP53
30butyrate458.6ATF2, TP53, MUC1, CDKN2A
31n acetylcysteine458.6CDKN2A, STAT3, TP53
325-aza-2deoxycytidine458.5TP53, TP73, STAT3, CDKN2A
33sb 20358045 619.4STAT3, TP53, ATF2
34paclitaxel45 51 1110.4ATF2, TP53, STAT3, CDKN2A
35tyrosine458.4KRT1, STAT3, MUC1, TP73, ATF2
36cycloheximide458.3CDKN2A, STAT3, TP53, ATF2
37progesterone45 29 61 24 1112.3TP53, TP73, MUC1, KRT1, CDKN2A
38h2o2458.3ATF2, TP53, STAT3, CDKN2A
395fluorouracil458.1TP53, TP73, MUC1, STAT3, CDKN2A
40actinomycin d458.1TP53, TP73, MUC1, STAT3, CDKN2A
41vegf458.1TP53, TP73, MUC1, STAT3, CDKN2A
42arginine458.1TP53, TP73, STAT3, KRT1, CDKN2A
43threonine458.0ATF2, TP73, MUC1, STAT3, KRT1, CDKN2A
44doxorubicin45 51 1110.0ATF2, TP53, TP73, STAT3, CDKN2A
45oligonucleotide457.9ATF2, TP53, TP73, STAT3, CDKN2A
46paraffin457.7TP53, TP73, MUC1, STAT3, KRT1, CDKN2A
47serine457.6ATF2, TP53, MUC1, STAT3, KRT1, CDKN2A
48cisplatin45 51 61 1110.6ATF2, TP53, TP73, MUC1, STAT3, CDKN2A
49estrogen457.2CDKN2A, ATF2, TP53, TP73, MUC1, STAT3
50retinoic acid45 248.2ATF2, TP53, TP73, MUC1, STAT3, KRT1

GO Terms for genes affiliated with Eccrine Porocarcinoma

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16Gene Ontology
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Cellular components related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.3MUC1, TP53
2nuclear bodyGO:0166049.2CDKN2A, TP53
3chromatinGO:0007859.1TP53, TP73
4nucleoplasmGO:0056548.0CDKN2A, STAT3, TP53, ATF2
5nucleolusGO:0057307.7CDKN2A, STAT3, TP53, ATF2

Biological processes related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP73
2replicative senescenceGO:0903999.4CDKN2A, TP53
3response to X-rayGO:0101659.4TP73, TP53
4release of cytochrome c from mitochondriaGO:0018369.4TP73, TP53
5positive regulation of cell cycle arrestGO:0711589.4TP53, CDKN2A
6response to gamma radiationGO:0103329.3TP73, TP53
7protein tetramerizationGO:0512629.3TP53, TP73
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.3TP53, TP73
9cellular response to UVGO:0346449.2TP73, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.2TP53, MUC1
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.1MUC1, TP73, TP53
12cell cycle arrestGO:0070509.0CDKN2A, TP73, TP53
13cellular response to DNA damage stimulusGO:0069748.9ATF2, TP53, TP73
14Ras protein signal transductionGO:0072658.8CDKN2A, TP53
15negative regulation of transcription from RNA polymerase II promoterGO:0001228.6STAT3, TP73, TP53
16positive regulation of transcription, DNA-templatedGO:0458938.4TP53, TP73, STAT3, CDKN2A
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CDKN2A, STAT3, TP73, TP53

Molecular functions related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.3CDKN2A, TP53
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.1TP53, ATF2
3damaged DNA bindingGO:0036849.1TP53, TP73
4protein phosphatase bindingGO:0199038.7STAT3, TP53
5transcription regulatory region DNA bindingGO:0442128.7STAT3, TP73, TP53
6chromatin bindingGO:0036828.7TP73, TP53, ATF2
7p53 bindingGO:0020398.5CDKN2A, MUC1, TP73, TP53
8transcription factor bindingGO:0081348.3TP53, TP73, STAT3, CDKN2A
9sequence-specific DNA binding transcription factor activityGO:0037008.1ATF2, TP53, TP73, STAT3
10protein kinase bindingGO:0199017.8ATF2, TP53, TP73, STAT3, CDKN2A
11protein bindingGO:0055156.9ATF2, TP53, TP73, MUC1, STAT3, KRT1

Products for genes affiliated with Eccrine Porocarcinoma

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Sources for Eccrine Porocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet