MCID: ECC004
MIFTS: 49

Eccrine Porocarcinoma malady

Skin diseases category

Summaries for Eccrine Porocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A malignant acrospiroma (also known as \"Malignant poroma,\" \"Porocarcinoma\", and... more...

MalaCards: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to keratosis and squamous cell carcinoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are TGF-beta Receptor Signaling Pathway and Apoptosis Modulation and Signaling. The compounds vincristine and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung, and related mouse phenotypes are embryogenesis and vision/eye.

Aliases & Classifications for Eccrine Porocarcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

eccrine porocarcinoma 8 44 60
eccrine porocarcinoma of skin 8
malignant eccrine poroma 8
porocarcinoma 8


External Ids:

Disease Ontology8 DOID:7566
MeSH34 D057090
NCIt39 C5560

Related Diseases for Eccrine Porocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1keratosis30.5KRT1
2squamous cell carcinoma30.4STAT3, MUC1, CDKN2A, KRT1, TP73, TP53
3cervical cancer30.2TP53, KRT1, CDKN2A
4retinoblastoma30.2STAT3, ATF2, CDKN2A, TP73, TP53
5melanoma30.2STAT3, ATF2, CDKN2A, TP73, TP53
6vulvar eccrine porocarcinoma10.5
7lymphangitis10.3
8basaloid squamous cell carcinoma10.2
9erysipeloid10.2
10cervicitis10.2
11lymphedema10.2
12seborrheic keratosis10.2
13acrospiroma10.2
14angiosarcoma10.0MUC1
15rhabdoid tumor10.0MUC1
16leukoplakia10.0KRT1
17wilms tumor10.0TP73
18pilocytic astrocytoma10.0TP73
19lichen planus10.0KRT1
20gastritis10.0TP53
21gallbladder cancer10.0TP53
22laryngeal benign neoplasm10.0TP53
23neuroblastoma10.0TP53
24actinic keratosis10.0TP53
25lynch syndrome10.0TP53
26rhabdomyosarcoma10.0TP53
27chondrosarcoma10.0MUC1
28ductal carcinoma in situ10.0TP53
29plasma cell leukemia10.0TP73
30xeroderma pigmentosum10.0TP53
31liposarcoma10.0TP53
32ulcerative colitis10.0TP53
33gastrointestinal stromal tumor10.0STAT3
34dermatofibrosarcoma protuberans10.0MUC1
35choroid plexus papilloma10.0TP53
36fibrosarcoma10.0STAT3
37myeloma10.0STAT3
38mycosis fungoides10.0STAT3
39benign mesothelioma10.0TP53
40hepatitis b10.0STAT3
41inflammatory bowel disease10.0STAT3
42arthritis10.0STAT3
43chordoma10.0KRT1, MUC1
44ischemia10.0ATF2
45ependymoma10.0MUC1, TP73
46epithelioid sarcoma10.0MUC1, KRT1
47neurofibroma10.0TP73, MUC1
48hemangioblastoma10.0MUC1
49syringoma10.0KRT1, MUC1
50sarcoma10.0TP53, MUC1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Clinical Features for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Eccrine Porocarcinoma:

32
Skin, Lymph node, Lung, Colon

Animal Models for Eccrine Porocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.0ATF2
2MP:00053919.8ATF2, MUC1
3MP:00053769.8ATF2, KRT1
4MP:00053909.5STAT3, ATF2
5MP:00107718.3TP53, KRT1, CDKN2A, STAT3
6MP:00053888.3STAT3, ATF2, TP73, TP53
7MP:00030128.2TP53, KRT1, CDKN2A, MUC1
8MP:00053798.2TP53, TP73, CDKN2A, STAT3
9MP:00053817.8STAT3, MUC1, CDKN2A, TP73, TP53
10MP:00053707.8TP53, CDKN2A, MUC1, ATF2, STAT3
11MP:00020067.4TP53, TP73, CDKN2A, MUC1, ATF2, STAT3
12MP:00053977.2STAT3, ATF2, CDKN2A, TP73, TP53
13MP:00107687.0STAT3, ATF2, CDKN2A, KRT1, TP73, TP53

Publications for Eccrine Porocarcinoma

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50PubMed
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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Eccrine porocarcinoma: clinical and pathological report of eight cases. (24403888)
2013
2
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. (23773127)
2013
3
Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report. (22689795)
2012
4
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. (21859481)
2011
5
Primary eccrine porocarcinoma of the finger with transit forearm and axillary metastasis. (21042176)
2011
6
Eccrine porocarcinoma presenting with unusual clinical manifestations: a case report and review of the literature. (22028580)
2011
7
Metastatic eccrine porocarcinoma: report of a case and review of the literature. (21410982)
2011
8
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. (20976127)
2010
9
Eccrine porocarcinoma presenting with scrotal lymphedema: a case report and review of systemic treatment. (20089564)
2010
10
Rectal and gynecologic amputation for a giant eccrine porocarcinoma of the pelvic floor. (19350871)
2009
11
Eccrine porocarcinoma of the auricle: a case report. (19605333)
2009
12
Eccrine porocarcinoma of the upper eyelid. (18520840)
2008
13
Interesting response to concurrent chemoradiation in metastatic eccrine porocarcinoma. (18837710)
2008
14
Eccrine porocarcinoma: a rare but sometimes fatal malignant neoplasm. (17338701)
2007
15
Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. (17004985)
2007
16
Eccrine porocarcinoma: a case with an obscure primary tumor diagnosed from lymph node metastasis. (17414442)
2007
17
Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature. (17214856)
2007
18
Eccrine porocarcinoma of the face involving eyelids: a rare case report. (17294909)
2006
19
Eccrine porocarcinoma. (16638385)
2006
20
Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma. (16815204)
2006
21
Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma. (16865245)
2006
22
Eccrine porocarcinoma (malignant eccrine poroma): a case report. (16150225)
2005
23
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. (15206695)
2004
24
Metastatic eccrine porocarcinoma presenting with lymphoedema. (15030359)
2004
25
Antitumour activity of paclitaxel and interferon-alpha in a case of metastatic eccrine porocarcinoma. (15196167)
2004
26
Clear cell eccrine porocarcinoma with extensive cutaneous metastasis and peripheral lymphocyte dysfunction. (14632816)
2003
27
Aberrant expression of p16 and RB protein in eccrine porocarcinoma. (12207741)
2002
28
Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. (11332156)
2001
29
Eccrine porocarcinoma in a child that evolved rapidly from an eccrine poroma. (11568910)
2001
30
A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: biological characterization and clinical aggressiveness. (11053985)
2000
31
Eccrine porocarcinoma treated with Mohs micrographic surgery: A report of five cases. (10594609)
1999
32
Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient. (10491509)
1999
33
Eccrine porocarcinoma with melanocyte colonization. (9580812)
1998
34
Eccrine porocarcinoma. (9236878)
1997
35
Metastasizing eccrine porocarcinoma: report of a case and review of the literature. (8912607)
1996
36
Eccrine porocarcinoma. (8828278)
1996
37
Vulvar eccrine porocarcinoma. (8812539)
1996
38
Pedal papule. Eccrine porocarcinoma (EPC) in association with poroma. (7857121)
1995
39
Eccrine porocarcinoma. (8159010)
1994
40
Immunohistochemistry of eccrine porocarcinoma. (21607315)
1994
41
A unique case of extramammary Paget's disease. Derivation from eccrine porocarcinoma? (1335216)
1992
42
Eccrine porocarcinoma of the face. (1325487)
1992
43
Eccrine porocarcinoma. (1653154)
1991
44
Metastasizing eccrine porocarcinoma. Report of two cases with fatal outcome. (1652130)
1991
45
Epidermotropic eccrine porocarcinoma. (1999525)
1991
46
Eccrine porocarcinoma. (2834991)
1988
47
Three cases of eccrine porocarcinoma. (3015186)
1986
48
Metastasizing eccrine porocarcinoma developing in a sebaceous nevus of Jadassohn. Report of a case. (2983619)
1985
49
Eccrine porocarcinoma. Ultrastructural and immunological study. (6092444)
1984
50
Loss of membrane B2 microglobulin in eccrine porocarcinoma. Its association with the histopathologic and clinical criteria of malignancy. (6326692)
1984

Genetic Variations for Eccrine Porocarcinoma

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Expression for genes affiliated with Eccrine Porocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for genes affiliated with Eccrine Porocarcinoma

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37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 29KEGG, 53Reactome
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Pathways related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ATF2, TP73
2
Hide members
9.2TP53, TP73
39.1ATF2, TP53
4
Signal transduction JNK pathway
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9.1TP53, ATF2
59.0TP53, CDKN2A
69.0TP53, CDKN2A
7
Transcription P53 signaling pathway
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9.0TP53, CDKN2A
8
Hide members
8.9ATF2, CDKN2A, KRT1
98.8TP53, MUC1, STAT3
10
Hide members
8.7TP53, TP73, STAT3
118.7ATF2, TP73, TP53
128.6STAT3, ATF2, TP53
13
Hide members
8.6TP53, ATF2, STAT3
14
Hide members
8.6TP53, ATF2, STAT3
15
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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8.6STAT3, ATF2, TP53
16
Hide members
8.6TP53, TP73, CDKN2A
178.6TP53, TP73, CDKN2A
18
Hide members
8.6CDKN2A, TP73, TP53
198.5TP53, CDKN2A, STAT3
20
Hide members
8.5TP53, CDKN2A, STAT3
218.5STAT3, CDKN2A, TP53
228.5TP53, CDKN2A, ATF2
23
Hide members
8.2STAT3, ATF2, TP73, TP53
248.0TP53, CDKN2A, ATF2, STAT3
25
Hide members
7.6STAT3, ATF2, MUC1, CDKN2A, TP53

Compounds for genes affiliated with Eccrine Porocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.4TP73
2butyrate4410.4ATF2
3serine4410.0KRT1, STAT3
4[alcl]449.8STAT3, MUC1
5hematoxylin449.5MUC1, CDKN2A, KRT1
6biotin44 11 2411.4KRT1, CDKN2A, MUC1
7acnu449.4CDKN2A, TP53
8hpvs449.3TP53, CDKN2A
95-methylcytosine44 2410.3TP53, CDKN2A
10olomoucine44 1110.3TP53, CDKN2A
11chloramphenicol44 2 1111.3MUC1, CDKN2A, TP73
12temozolomide44 1110.2CDKN2A, TP53
13gemcitabine44 49 1111.2TP53, TP73, MUC1
14agar449.2STAT3, MUC1, CDKN2A
15aflatoxin b144 2410.2TP53, CDKN2A
16paraffin449.2TP73, KRT1, MUC1, STAT3
17bcnu449.1CDKN2A, TP53
18parthenolide44 210.1TP53, STAT3
19noxa449.1TP53, TP73
20crcs449.1TP53, CDKN2A, MUC1
2112-o-tetradecanoylphorbol 13-acetate449.1STAT3, ATF2, MUC1, KRT1
22cytarabine44 49 1111.0TP53, CDKN2A, MUC1
23o6-methylguanine449.0TP53, TP73, CDKN2A
24sp 60012544 5910.0STAT3, ATF2, TP53
25retinoid448.9TP53, KRT1, STAT3
26camptothecin44 59 1110.9CDKN2A, TP73, TP53
27roscovitine448.9TP53, CDKN2A, STAT3
28paclitaxel44 49 1110.9STAT3, CDKN2A, TP53
29flavopiridol44 119.9TP53, CDKN2A, STAT3
30testosterone44 59 11 2411.9KRT1, CDKN2A, MUC1, STAT3
31docetaxel44 49 59 1111.9TP53, CDKN2A, STAT3
32mg 13244 599.8TP53, CDKN2A, STAT3
33arsenite44 249.8STAT3, CDKN2A, TP53
34adriamycin448.6MUC1, CDKN2A, TP73, TP53
35sb 20358044 599.6STAT3, ATF2, TP53
36n acetylcysteine448.6TP53, CDKN2A, STAT3
375-aza-2deoxycytidine448.5STAT3, CDKN2A, TP73, TP53
38tyrosine448.5STAT3, ATF2, MUC1, KRT1, TP73
39tamoxifen44 49 28 1111.5TP53, MUC1, STAT3
40h2o2448.3STAT3, ATF2, CDKN2A, TP53
41progesterone44 59 28 11 2412.2MUC1, CDKN2A, KRT1, TP73, TP53
425fluorouracil448.1STAT3, MUC1, CDKN2A, TP73, TP53
43actinomycin d448.1TP53, TP73, CDKN2A, MUC1, STAT3
44vegf448.1STAT3, MUC1, CDKN2A, TP73, TP53
45arginine448.1STAT3, CDKN2A, KRT1, TP73, TP53
46threonine448.0STAT3, ATF2, MUC1, CDKN2A, KRT1, TP73
47doxorubicin44 49 1110.0STAT3, ATF2, CDKN2A, TP73, TP53
48oligonucleotide448.0STAT3, ATF2, CDKN2A, TP73, TP53
49cisplatin44 49 59 1110.6STAT3, ATF2, MUC1, CDKN2A, TP73, TP53
50retinoic acid44 248.2STAT3, ATF2, MUC1, CDKN2A, KRT1, TP73

GO Terms for genes affiliated with Eccrine Porocarcinoma

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16Gene Ontology
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Cellular components related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.7TP53, CDKN2A
2nucleoplasmGO:0056548.0TP53, CDKN2A, ATF2, STAT3

Biological processes related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP73
2response to X-rayGO:0101659.3TP53, TP73
3release of cytochrome c from mitochondriaGO:0018369.3TP73, TP53
4replicative senescenceGO:0903999.3TP53, CDKN2A
5positive regulation of cell cycle arrestGO:0711589.2CDKN2A, TP53
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.2TP53, TP73
7cellular response to UVGO:0346449.2TP53, TP73
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.1TP53, TP73, MUC1
9response to gamma radiationGO:0103329.1TP53, TP73
10protein tetramerizationGO:0512628.9TP53, TP73
11response to DNA damage stimulusGO:0069748.9TP53, TP73, ATF2
12cell cycle arrestGO:0070508.8CDKN2A, TP73, TP53
13positive regulation of transcription, DNA-dependentGO:0458938.3STAT3, CDKN2A, TP73, TP53
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.2TP53, TP73, CDKN2A, STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:0036849.2TP53, TP73
2MDM2/MDM4 family protein bindingGO:0973719.1TP53, CDKN2A
3transcription regulatory region DNA bindingGO:0442128.7STAT3, TP73, TP53
4p53 bindingGO:0020398.4TP53, TP73, CDKN2A, MUC1
5chromatin bindingGO:0036828.4TP53, TP73, ATF2
6transcription factor bindingGO:0081348.2TP53, TP73, CDKN2A, STAT3
7sequence-specific DNA binding transcription factor activityGO:0037008.1STAT3, ATF2, TP73, TP53
8protein kinase bindingGO:0199017.7STAT3, ATF2, CDKN2A, TP73, TP53
9protein bindingGO:0055156.7STAT3, ATF2, MUC1, CDKN2A, KRT1, TP73

Products for genes affiliated with Eccrine Porocarcinoma

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Sources for Eccrine Porocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet