MCID: ECC004
MIFTS: 44

Eccrine Porocarcinoma malady

Skin diseases category

Summaries for Eccrine Porocarcinoma

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Wikipedia:63 A malignant acrospiroma (also known as hidradenocarcinoma, and \"Spiradenocarcinoma\") is a sweat gland... more...

MalaCards based summary: Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to retinoblastoma and melanoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are IL12-mediated signaling events and IL-5 Signaling Pathway. The compounds hematoxylin and biotin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and colon, and related mouse phenotypes are pigmentation and reproductive system.

Aliases & Classifications for Eccrine Porocarcinoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT
See all sources

Eccrine Porocarcinoma, Aliases & Descriptions:

Name: Eccrine Porocarcinoma 9 43 60
Eccrine Porocarcinoma of Skin 9
 
Malignant Eccrine Poroma 9
Porocarcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:7566
NCIt38 C5560
MeSH33 D057090

Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1retinoblastoma29.5CDKN2A, STAT3, TP73, ATF2, TP53
2melanoma29.5STAT3, ATF2, TP53, CDKN2A, TP73
3vulvar eccrine porocarcinoma10.6
4actinic keratosis10.5TP53
5choroid plexus papilloma10.4TP53
6lymphangitis10.4
7cervicitis10.4
8keratosis10.4
9acrospiroma10.4
10epithelioid sarcoma10.3KRT1, MUC1
11syringoma10.3KRT1, MUC1
12renal cell carcinoma10.3TP53
13chordoma10.3KRT1, MUC1
14neuroendocrine tumor10.3MUC1, KRT1
15lymphedema10.3
16basaloid squamous cell carcinoma10.3
17erysipeloid10.3
18malignant mixed mullerian tumor10.2MUC1, TP53
19sarcoma, synovial10.2KRT1, MUC1
20neurofibroma10.2MUC1, TP73
21ependymoma10.2MUC1, TP73
22malignant peripheral nerve sheath tumor10.2CDKN2A, MUC1
23leiomyosarcoma10.2TP53, MUC1
24oropharynx cancer10.2CDKN2A, TP53
25oligodendroglioma10.2TP73, CDKN2A
26li-fraumeni syndrome10.1TP53, CDKN2A
27nasopharynx carcinoma10.1TP53, CDKN2A
28cervical squamous cell carcinoma10.1CDKN2A, TP73
29cervical intraepithelial neoplasia10.1CDKN2A, TP73
30precursor b-cell acute lymphoblastic leukemia10.1TP73, CDKN2A
31mesothelioma, somatic10.1MUC1, CDKN2A
32meningioma, familial10.1MUC1, TP73, KRT1
33barrett esophagus/esophageal adenocarcinoma10.1CDKN2A, TP53
34mesothelioma10.1MUC1, CDKN2A
35cholangiocarcinoma10.1TP53, MUC1
36esophageal cancer10.1TP53, CDKN2A
37skin benign neoplasm10.1STAT3, KRT1
38anaplastic large cell lymphoma10.0MUC1, STAT3
39bladder cancer, somatic10.0TP53, CDKN2A
40thyroid cancer10.0TP53, TP73
41small cell cancer of the lung, somatic10.0CDKN2A, TP53, MUC1
42lung cancer10.0TP53, CDKN2A, MUC1
43thyroid carcinoma, papillary10.0STAT3, KRT1
44laryngeal squamous cell carcinoma9.9CDKN2A, TP73, TP53
45grade iii astrocytoma9.9CDKN2A, TP73, TP53
46papilloma9.9TP53, TP73, CDKN2A
47oral cancer9.9CDKN2A, TP53, TP73
48endometrial cancer9.9TP53, TP73, CDKN2A
49cervical cancer, somatic9.9TP73, CDKN2A, TP53
50pancreatic cancer9.9STAT3, MUC1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to eccrine porocarcinoma

Symptoms for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Eccrine Porocarcinoma

Search NIH Clinical Center for Eccrine Porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

31
Skin, Lymph node, Colon, Lung

Animal Models for Eccrine Porocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7TP53, KRT1, CDKN2A
2MP:00053898.1CDKN2A, STAT3, TP73, TP53
3MP:00053818.0TP53, TP73, MUC1, STAT3, CDKN2A
4MP:00053707.9ATF2, TP53, MUC1, STAT3, CDKN2A
5MP:00053797.9TP53, TP73, MUC1, STAT3, CDKN2A
6MP:00028737.8ATF2, TP53, MUC1, STAT3
7MP:00053887.8ATF2, TP53, TP73, STAT3, CDKN2A
8MP:00053857.8ATF2, TP53, TP73, STAT3, KRT1
9MP:00053907.7ATF2, TP53, TP73, STAT3, CDKN2A
10MP:00053807.7ATF2, TP53, TP73, STAT3, CDKN2A
11MP:00053867.6CDKN2A, STAT3, TP73, TP53, ATF2
12MP:00107717.5ATF2, TP53, MUC1, STAT3, KRT1, CDKN2A
13MP:00020067.5CDKN2A, STAT3, MUC1, TP73, TP53, ATF2
14MP:00053917.5ATF2, TP53, TP73, MUC1, STAT3, CDKN2A
15MP:00053847.4CDKN2A, STAT3, TP73, TP53, ATF2
16MP:00053977.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
17MP:00053877.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
18MP:00036317.4ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
19MP:00053787.3ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
20MP:00107687.3ATF2, TP53, TP73, STAT3, KRT1, CDKN2A
21MP:00053767.1ATF2, TP53, TP73, MUC1, STAT3, KRT1

Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Eccrine porocarcinoma: A wolf in sheep's clothing. (25803156)
2015
2
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. (25076888)
2014
3
Eccrine porocarcinoma: a report of 2 cases and review of the literature. (24505584)
2014
4
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. (24803063)
2014
5
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. (24003279)
2013
6
Eccrine porocarcinoma: clinical and pathological report of eight cases. (24403888)
2013
7
Successful management of metastatic eccrine porocarcinoma. (24282649)
2013
8
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. (23773127)
2013
9
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. (23917787)
2013
10
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. (22108500)
2012
11
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. (22150617)
2012
12
Eccrine porocarcinoma of the vulva: a case report and review of literature. (21131825)
2011
13
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. (21859481)
2011
14
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. (22693407)
2011
15
Aggressive eccrine porocarcinoma associated with haematological disorders: report of two cases. (20518919)
2010
16
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. (20976127)
2010
17
A case of clear cell eccrine porocarcinoma. (20711273)
2010
18
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report. (20492705)
2010
19
Recurrent pigmented eccrine porocarcinoma presenting as carcinoma erysipeloides. (19747328)
2009
20
Eccrine porocarcinoma. (19076620)
2008
21
Eccrine porocarcinoma of the upper eyelid. (18520840)
2008
22
Eccrine porocarcinoma: a rare but sometimes fatal malignant neoplasm. (17338701)
2007
23
Metastatic eccrine porocarcinoma detected on FDG PET/CT. (17710036)
2007
24
Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. (17004985)
2007
25
Eccrine porocarcinoma of the face involving eyelids: a rare case report. (17294909)
2006
26
Eccrine porocarcinoma arising from preexisting eccrine poroma of the scalp after radiotherapy for cervical cancer. (17083898)
2006
27
Eccrine porocarcinoma. (16638385)
2006
28
Eccrine porocarcinoma of the upper eyelid. (16197432)
2005
29
Eccrine porocarcinoma and eccrine poroma arising in a scar. (15214932)
2004
30
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. (15206695)
2004
31
Eccrine porocarcinoma of the penis. (12544320)
2003
32
Metastatic eccrine porocarcinoma: a 5.6-year follow-up study of a patient treated with a combined therapeutic protocol. (14725669)
2003
33
Eccrine porocarcinoma: A case report and review of the literature. (24115860)
2003
34
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. (11395548)
2001
35
Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. (11332156)
2001
36
A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: biological characterization and clinical aggressiveness. (11053985)
2000
37
Eccrine porocarcinoma treated with Mohs micrographic surgery: A report of five cases. (10594609)
1999
38
Eccrine porocarcinoma: a case report. (10561775)
1999
39
Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient. (10491509)
1999
40
Eccrine porocarcinoma with melanocyte colonization. (9580812)
1998
41
Eccrine porocarcinoma. Report of nine cases. (9357503)
1997
42
Metastasizing eccrine porocarcinoma: report of a case and review of the literature. (8912607)
1996
43
Eccrine porocarcinoma. (8828278)
1996
44
A case of multiple eccrine porocarcinoma with stepping-stone distribution on the foot. (7650246)
1995
45
A unique case of extramammary Paget's disease. Derivation from eccrine porocarcinoma? (1335216)
1992
46
A histopathological and ultrastructural study of eccrine porocarcinoma with special reference to its subtypes. (1317619)
1992
47
Eccrine porocarcinoma of the face. (1325487)
1992
48
Eccrine porocarcinoma. (1653154)
1991
49
Three cases of eccrine porocarcinoma. (3015186)
1986
50
Eccrine porocarcinoma: a case report with light microscopy and ultrastructure. (6296749)
1982

Variations for Eccrine Porocarcinoma

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Expression for genes affiliated with Eccrine Porocarcinoma

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Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for genes affiliated with Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.3ATF2, STAT3
29.3STAT3, ATF2
3
Show member pathways
9.3STAT3, ATF2
49.3STAT3, ATF2
5
Show member pathways
IFN-gamma pathway36
9.3STAT3, ATF2
6
Show member pathways
RAC1 signaling pathway36
9.3STAT3, ATF2
79.1TP53, CDKN2A
89.1TP53, CDKN2A
99.1CDKN2A, TP53
109.1TP53, CDKN2A
119.1TP53, CDKN2A
12
Show member pathways
9.1TP53, CDKN2A
139.1TP53, ATF2
149.1TP53, ATF2
15
Show member pathways
9.0STAT3, TP53
16
Show member pathways
9.0CDKN2A, ATF2, KRT1
17
Show member pathways
8.7TP53, CDKN2A, TP73
18
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.7CDKN2A, TP73, TP53
19
Show member pathways
DNA damage response36
8.7TP73, CDKN2A, TP53
20
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.7TP53, TP73, CDKN2A
21
Show member pathways
8.7TP73, CDKN2A, TP53
228.7ATF2, TP53, TP73
23
Show member pathways
ATM Signaling Pathway36
8.7TP53, TP73, ATF2
248.7MUC1, TP53, STAT3
258.6ATF2, CDKN2A, TP53
26
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.6TP73, STAT3, TP53
27
Show member pathways
8.5STAT3, TP53, CDKN2A
28
Show member pathways
8.5STAT3, CDKN2A, TP53
298.5TP53, CDKN2A, STAT3
308.5STAT3, TP53, CDKN2A
31
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
8.5TP53, STAT3, ATF2
32
Show member pathways
8.5STAT3, TP53, ATF2
33
Show member pathways
8.5ATF2, TP53, STAT3
34
Show member pathways
8.5ATF2, TP53, STAT3
35
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5ATF2, TP53, STAT3
36
Show member pathways
8.5TP53, STAT3, ATF2
378.5STAT3, TP53, ATF2
38
Show member pathways
8.1STAT3, ATF2, TP53, TP73
398.0ATF2, TP53, STAT3, CDKN2A
40
Show member pathways
8.0STAT3, TP53, CDKN2A, ATF2
41
Show member pathways
7.6STAT3, TP53, MUC1, ATF2, CDKN2A

Compounds for genes affiliated with Eccrine Porocarcinoma

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Compounds related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1hematoxylin439.6CDKN2A, KRT1, MUC1
2biotin43 24 1211.5KRT1, CDKN2A, MUC1
3[alcl]439.5STAT3, MUC1
4acnu439.5CDKN2A, TP53
5hpvs439.4TP53, CDKN2A
6chloramphenicol43 2 49 1212.3MUC1, CDKN2A, TP73
7olomoucine43 1210.3TP53, CDKN2A
85-methylcytosine43 2410.3TP53, CDKN2A
9gemcitabine43 49 1211.2MUC1, TP53, TP73
10temozolomide43 1210.2TP53, CDKN2A
11agar439.2CDKN2A, STAT3, MUC1
12crcs439.2TP53, CDKN2A, MUC1
13hmba439.1TP53, CDKN2A
14cytarabine43 49 1211.1TP53, MUC1, CDKN2A
15o6-methylguanine439.1CDKN2A, TP73, TP53
16vincristine43 49 1211.0CDKN2A, TP73, TP53
17camptothecin43 59 1211.0TP73, CDKN2A, TP53
1812-o-tetradecanoylphorbol 13-acetate439.0STAT3, ATF2, KRT1, MUC1
19roscovitine438.9CDKN2A, STAT3, TP53
20flavopiridol43 129.9TP53, STAT3, CDKN2A
21sp 60012543 599.9ATF2, STAT3, TP53
22testosterone43 59 24 1211.8MUC1, STAT3, CDKN2A, KRT1
23docetaxel43 49 59 1211.8STAT3, CDKN2A, TP53
24aflatoxin b143 249.8CDKN2A, TP53
25egcg438.8CDKN2A, STAT3, TP53
26retinoid438.8STAT3, TP53, KRT1
27mg 13243 599.8TP53, CDKN2A, STAT3
28arsenite43 249.8CDKN2A, STAT3, TP53
29adriamycin438.7TP53, CDKN2A, TP73, MUC1
30butyrate438.6ATF2, MUC1, TP53, CDKN2A
31n acetylcysteine438.6CDKN2A, TP53, STAT3
325-aza-2deoxycytidine438.5TP53, STAT3, TP73, CDKN2A
33sb 20358043 599.4TP53, ATF2, STAT3
34paclitaxel43 49 1210.4ATF2, TP53, STAT3, CDKN2A
35tyrosine438.4MUC1, KRT1, STAT3, ATF2, TP73
36cycloheximide438.3STAT3, ATF2, CDKN2A, TP53
37progesterone43 28 59 24 1212.3CDKN2A, TP53, MUC1, TP73, KRT1
38h2o2438.3ATF2, TP53, STAT3, CDKN2A
395fluorouracil438.1MUC1, TP73, TP53, CDKN2A, STAT3
40actinomycin d438.1CDKN2A, MUC1, STAT3, TP53, TP73
41vegf438.1TP73, TP53, MUC1, CDKN2A, STAT3
42arginine438.1CDKN2A, KRT1, STAT3, TP73, TP53
43threonine438.0KRT1, STAT3, MUC1, TP73, ATF2, CDKN2A
44doxorubicin43 49 1210.0ATF2, STAT3, TP53, CDKN2A, TP73
45oligonucleotide437.9STAT3, TP73, TP53, CDKN2A, ATF2
46paraffin437.7KRT1, TP53, TP73, MUC1, STAT3, CDKN2A
47serine437.6TP53, CDKN2A, KRT1, STAT3, MUC1, ATF2
48cisplatin43 49 59 1210.6CDKN2A, STAT3, TP53, MUC1, ATF2, TP73
49estrogen437.2KRT1, ATF2, TP53, MUC1, STAT3, CDKN2A
50retinoic acid43 248.2STAT3, MUC1, KRT1, CDKN2A, TP53, TP73

GO Terms for genes affiliated with Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.3TP53, MUC1
2nuclear bodyGO:00166049.2TP53, CDKN2A
3chromatinGO:00007859.1TP53, TP73
4nucleoplasmGO:00056548.0ATF2, TP53, STAT3, CDKN2A
5nucleolusGO:00057307.7CDKN2A, STAT3, TP53, ATF2

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:00315719.5TP53, TP73
2replicative senescenceGO:00903999.4CDKN2A, TP53
3response to X-rayGO:00101659.4TP73, TP53
4release of cytochrome c from mitochondriaGO:00018369.4TP73, TP53
5positive regulation of cell cycle arrestGO:00711589.4TP53, CDKN2A
6response to gamma radiationGO:00103329.3TP73, TP53
7protein tetramerizationGO:00512629.3TP53, TP73
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.3TP53, TP73
9cellular response to UVGO:00346449.2TP73, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.2TP53, MUC1
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.1MUC1, TP73, TP53
12cell cycle arrestGO:00070509.0CDKN2A, TP73, TP53
13cellular response to DNA damage stimulusGO:00069748.9ATF2, TP53, TP73
14Ras protein signal transductionGO:00072658.8CDKN2A, TP53
15negative regulation of transcription from RNA polymerase II promoterGO:00001228.6STAT3, TP73, TP53
16positive regulation of transcription, DNA-templatedGO:00458938.4TP53, TP73, STAT3, CDKN2A
17positive regulation of transcription from RNA polymerase II promoterGO:00459448.3CDKN2A, STAT3, TP73, TP53

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:00973719.3CDKN2A, TP53
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00010779.1TP53, ATF2
3damaged DNA bindingGO:00036849.1TP53, TP73
4protein phosphatase bindingGO:00199038.7STAT3, TP53
5transcription regulatory region DNA bindingGO:00442128.7STAT3, TP73, TP53
6chromatin bindingGO:00036828.7TP73, TP53, ATF2
7p53 bindingGO:00020398.5CDKN2A, MUC1, TP73, TP53
8transcription factor bindingGO:00081348.3TP53, TP73, STAT3, CDKN2A
9sequence-specific DNA binding transcription factor activityGO:00037008.1ATF2, TP53, TP73, STAT3
10protein kinase bindingGO:00199017.8ATF2, TP53, TP73, STAT3, CDKN2A
11protein bindingGO:00055156.9ATF2, TP53, TP73, MUC1, STAT3, KRT1

Products for genes affiliated with Eccrine Porocarcinoma

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Sources for Eccrine Porocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet