MCID: ECC004
MIFTS: 36

Eccrine Porocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Eccrine Porocarcinoma

Aliases & Descriptions for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 50 52 42 14 69
Eccrine Porocarcinoma of Skin 12 50
Malignant Eccrine Poroma 12 50
Porocarcinoma 12 50

Classifications:



External Ids:

Disease Ontology 12 DOID:7566
MeSH 42 D057090
NCIt 47 C5560
SNOMED-CT 64 128685001 254708001
UMLS 69 C1266065

Summaries for Eccrine Porocarcinoma

NIH Rare Diseases : 50 eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. they affect the eccrine sweat glands, which are the major sweat glands of the body. eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). they are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. treatment usually involves surgery to remove the tumor. last updated: 12/13/2016

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to squamous cell carcinoma and vulvar eccrine porocarcinoma. An important gene associated with Eccrine Porocarcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. The drugs nivolumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung.

Wikipedia : 71 A malignant acrospiroma (also known as hidradenocarcinoma, and \"Spiradenocarcinoma\") is a sweat gland... more...

Related Diseases for Eccrine Porocarcinoma

Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
id Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.3 KRT1 KRT10
2 vulvar eccrine porocarcinoma 12.2
3 lupus - neurological sequelae 10.2 S100B VIM
4 benign schwannoma 10.2 S100B VIM
5 jejunal neuroendocrine tumor 10.2 S100B VIM
6 bradyopsia 10.2 KRT1 KRT10
7 erdheim-chester disease 10.2 KRT1 KRT10
8 palmoplantar keratoderma, nonepidermolytic 10.2 KRT1 KRT10
9 cavernous sinus meningioma 10.2 S100B VIM
10 episodic angioedema with eosinophilia 10.2 KRT1 KRT10
11 ciliary dyskinesia, primary, 1, with or without situs inversus 10.2 KRT1 KRT10
12 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 S100B VIM
13 dyslexia 10.2 S100B VIM
14 stomach diverticulosis 10.2 S100B VIM
15 mixed cell adenoma 10.2 KRT1 KRT10
16 skin glomus tumor 10.2 S100B VIM
17 immunodeficiency due to a classical component pathway complement deficiency 10.2 MUC1 VIM
18 marfanoid hypermobility syndrome 10.2 MUC1 VIM
19 keratosis palmoplantaris striata iii 10.2 KRT1 KRT10
20 autosomal recessive stickler syndrome 10.2 MUC1 VIM
21 endometrial stromal sarcoma 10.2 MUC1 VIM
22 onychocytic matricoma 10.2 S100B VIM
23 tanycytic ependymoma 10.2 MUC1 VIM
24 bladder adenocarcinoma 10.2 MUC1 VIM
25 avian influenza 10.2 MUC1 VIM
26 enchondromatosis dwarfism deafness 10.2 S100B VIM
27 testicular granulosa cell tumor 10.2 MUC1 VIM
28 petrous apex meningioma 10.1 MUC1 VIM
29 lymphangiosarcoma 10.1 MUC1 VIM
30 progeria 10.1 MUC1 VIM
31 colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas 10.1 KRT1 KRT10
32 coronary stenosis 10.1 MUC1 VIM
33 sebaceous adenoma 10.1 MUC1 VIM
34 his bundle tachycardia 10.1 S100B VIM
35 anal gland neoplasm 10.1 MUC1 VIM
36 cauda equina intradural extramedullary astrocytoma 10.1 MUC1 VIM
37 gestational trophoblastic neoplasm 10.1 MUC1 VIM
38 appendix mucinous cystadenocarcinoma 10.1 MUC1 VIM
39 chondroblastoma 10.1 MUC1 VIM
40 mesenchymoma 10.1 MUC1 VIM
41 omodysplasia 2 10.1 MUC1 VIM
42 scott syndrome 10.1 KRT1 KRT10
43 subependymal glioma 10.1 MUC1 VIM
44 congenital muscular dystrophy with hyperlaxity 10.1 MUC1 VIM
45 ovarian epithelial cancer 10.1 S100B VIM
46 differentiating neuroblastoma 10.1 MUC1 VIM
47 complication after organ transplantation 10.1 MUC1 STAT3
48 bowen's disease 10.1
49 carotid artery thrombosis 10.1 KRT1 KRT10
50 ichthyosis histrix, curth-macklin type 10.1 KRT1 KRT10

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma

Symptoms & Phenotypes for Eccrine Porocarcinoma

Drugs & Therapeutics for Eccrine Porocarcinoma

Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulins Phase 2
3 Antibodies, Monoclonal Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Not yet recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

Anatomical Context for Eccrine Porocarcinoma

MalaCards organs/tissues related to Eccrine Porocarcinoma:

39
Skin, Lymph Node, Lung, Colon

Publications for Eccrine Porocarcinoma

Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 136)
id Title Authors Year
1
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. ( 28087039 )
2017
2
Eccrine porocarcinoma of the vulva: a case report and review of the literature. ( 27832810 )
2016
3
Eccrine Porocarcinoma Presenting as a Hand Cyst. ( 27593487 )
2016
4
Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report. ( 27085107 )
2016
5
Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature. ( 26894080 )
2016
6
Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment. ( 27721767 )
2016
7
In-transit metastasis of advanced eccrine porocarcinoma. ( 26234455 )
2015
8
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. ( 25515648 )
2015
9
Eccrine porocarcinoma of the thumb in a patient with chronic exposure to benzene glue. ( 26078532 )
2015
10
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. ( 26333057 )
2015
11
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. ( 26205087 )
2015
12
Eccrine Porocarcinoma of Scalp: a Rare Case Report. ( 26516328 )
2015
13
Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. ( 25742554 )
2015
14
Metastatic eccrine porocarcinoma successfully treated with carboplatin and epirubicin chemotherapy. ( 26073009 )
2015
15
Response to taxane-based chemotherapy in metastatic eccrine porocarcinoma with extensive cutaneous involvement. ( 26837980 )
2015
16
Eccrine porocarcinoma: A wolf in sheep's clothing. ( 25803156 )
2015
17
Eccrine porocarcinoma with extensive cutaneous metastases. ( 26566927 )
2015
18
Eccrine porocarcinoma mimicking a venous leg ulcer. ( 26400442 )
2015
19
Intralesional Photodynamic Therapy for Eccrine Porocarcinoma. ( 26079590 )
2015
20
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015
21
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. ( 25984905 )
2015
22
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. ( 25076888 )
2014
23
Eccrine Porocarcinoma of the Eyelid in a Non-Caucasian Patient. ( 24841732 )
2014
24
Rapidly growing eccrine porocarcinoma of the face in a pregnant woman. ( 24621740 )
2014
25
A Rare Case of Eccrine Porocarcinoma of the Eyelid. ( 24576261 )
2014
26
Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrheic Keratoses. ( 24909550 )
2014
27
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. ( 24803063 )
2014
28
Eccrine porocarcinoma: a report of 2 cases and review of the literature. ( 24505584 )
2014
29
Metastatic eccrine porocarcinoma. ( 24087778 )
2013
30
Successful management of metastatic eccrine porocarcinoma. ( 24282649 )
2013
31
Eccrine porocarcinoma: a case report. ( 24551693 )
2013
32
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). ( 24016659 )
2013
33
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. ( 24003279 )
2013
34
Eccrine porocarcinoma: clinical and pathological report of eight cases. ( 24403888 )
2013
35
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. ( 23917787 )
2013
36
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. ( 23773127 )
2013
37
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. ( 22108500 )
2012
38
Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report. ( 22689795 )
2012
39
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. ( 22150617 )
2012
40
Eccrine porocarcinoma arising within an area of Bowen disease. ( 21973218 )
2012
41
Eccrine porocarcinoma of the vulva: a case report and review of literature. ( 21131825 )
2011
42
Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. ( 21711331 )
2011
43
Eccrine porocarcinoma of the external ear. ( 21853429 )
2011
44
Eccrine porocarcinoma of the lower extremity: a case report and review of literature. ( 21859481 )
2011
45
Eccrine porocarcinoma presenting with unusual clinical manifestations: a case report and review of the literature. ( 22028580 )
2011
46
Primary eccrine porocarcinoma of the finger with transit forearm and axillary metastasis. ( 21042176 )
2011
47
Eccrine porocarcinoma of scalp: an uncommon tumor at an unusual site. ( 22693407 )
2011
48
Metastatic eccrine porocarcinoma: report of a case and review of the literature. ( 21410982 )
2011
49
Dermoscopic features of eccrine porocarcinoma arising from hidroacanthoma simplex. ( 20976127 )
2010
50
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report. ( 20492705 )
2010

Variations for Eccrine Porocarcinoma

Cosmic variations for Eccrine Porocarcinoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM17596 PTCH1 skin,hand,carcinoma,NS c.863G>A p.G288D 4
2 COSM17602 PTCH1 skin,hand,carcinoma,NS c.1922C>T p.P641L 4
3 COSM17597 PTCH1 skin,hand,carcinoma,NS c.1977G>A p.Q659Q 4
4 COSM521 KRAS skin,hand,carcinoma,NS c.35G>A p.G12D 4

Expression for Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for Eccrine Porocarcinoma

Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.81 KRT10 MUC1 VIM
2
Show member pathways
11.59 KRT1 KRT10 KRT15
3 10.86 MUC1 STAT3 VIM

GO Terms for Eccrine Porocarcinoma

Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 KRT1 KRT10
2 intermediate filament GO:0005882 8.92 KRT1 KRT10 KRT15 VIM

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT1 KRT10 KRT15
2 cornification GO:0070268 9.33 KRT1 KRT10 KRT15
3 peptide cross-linking GO:0018149 9.32 KRT1 KRT10
4 skin epidermis development GO:0098773 8.96 KRT1 KRT10
5 astrocyte differentiation GO:0048708 8.62 S100B STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT15 VIM
2 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Eccrine Porocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....