MCID: ECH003
MIFTS: 51

Echinococcosis malady

Rare diseases, Infectious diseases, Liver diseases categories

Aliases & Classifications for Echinococcosis

About this section

Aliases & Descriptions for Echinococcosis:

Name: Echinococcosis 10 12 2 65 36
Hydatidosis 10 45
Echinococcosis, Unspecified, of Liver 10
Liver Echinococcus Unspecified 10
Echinococcosis, Pulmonary 65
Pulmonary Echinococcosis 10
 
Echinococcosis of Liver 10
Echinococcosis, Hepatic 65
Hepatic Echinococcosis 10
Echinococcal Disease 10
Hydatid Disease 10
Hydatids 47


Classifications:



External Ids:

Disease Ontology10 DOID:1496
ICD9CM29 122
NCIt42 C84682
MeSH36 D004443
ICD1027 B67, B67.8

Summaries for Echinococcosis

About this section
Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary: Echinococcosis, also known as hydatidosis, is related to hepatitis and sarcoma. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways are Primary immunodeficiency and IL4-mediated signaling events. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

CDC:2 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Related Diseases for Echinococcosis

About this section

Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 470)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.2IFNG, IL10, TNF
2sarcoma30.5CD40LG, CD79A
3mature teratoma30.2CD40LG, CD79A, IL6
4acquired immunodeficiency syndrome30.1IL10, IL6, TNF
5salpingitis30.0CD40LG, CD79A, CD8A
6intestinal obstruction29.9IFNG, IL10, TNF
7lymphangioma29.8IFNG, IL10, TNF
8aspergillosis29.8CD79A, IFNG, IL10, IL5
9acute poststreptococcal glomerulonephritis29.7IFNG, IL10, TNF
10uremia29.6CD40LG, CD79A, IL10, IL5
11tuberculosis29.6IFNG, IL10, IL6, TNF
12cauda equina syndrome29.4CD40LG, IFNG, IL10, IL6
13pneumothorax29.3CD40LG, IL10, IL5, IL6, TNF
14rheumatoid arthritis28.5CD40LG, CD79A, HLA-B, HLA-DRB1, IFNG, IL10
15cystic echinococcosis11.3
16alveolar echinococcosis11.3
17cysticercosis10.6
18polycystic echinococcosis10.6
19cerebritis10.5
20taeniasis10.5
21peritonitis10.4
22postinfectious encephalomyelitis10.3HLA-B, HLA-DRB1
23budd-chiari syndrome10.3
24childhood cerebellar astrocytic neoplasm10.3HLA-B, HLA-DRB1
25choledochal cyst10.3
26xanthogranulomatous pyelonephritis10.3HLA-B, HLA-DRB1
27cryoglobulinemia10.3HLA-B, IL6
28hepatic tuberculosis10.3CD8A, TNF
29cardiac tamponade10.3
30impetigo herpetiformis10.3CD79A, HLA-B
31acneiform dermatitis10.3HLA-B, TNF
32acute allergic sanguinous otitis media10.2CD79A, IL6
33olecranon bursitis10.2CD40LG, CD79A
34bilateral hyperactive labyrinth10.2CD40LG, CD79A
35calabro syndrome10.2CD40LG, CD79A
36punctate porokeratosis10.2IL10, TNF
37pulmonary edema10.2CD40LG, CD79A
38ovarian malignant mesothelioma10.2CD40LG, CD79A
39photoallergic dermatitis10.2CD40LG, CD79A
40tuberculous epididymitis10.2CD40LG, CD79A
41mammary paget's disease10.2CD40LG, CD79A
42crohn's disease10.2IL6, TNF
43atopic dermatitis10.2CD40LG, CD79A
44primary progressive freezing gait10.2IL10, TNF
45noonan syndrome 210.2HLA-B, HLA-DRB1, TNF
46bilateral retinoblastoma10.2CD40LG, CD79A
47cryoglobulinemia, familial mixed10.2CD40LG, CD79A
48matsoukas liarikos giannika syndrome10.2MT-ATP6, TNF
49lichen planus10.2CD40LG, CD79A
50clear cell cystadenofibroma10.2CD40LG, CD79A

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to echinococcosis

Symptoms for Echinococcosis

About this section

Drugs & Therapeutics for Echinococcosis

About this section

Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1BenzimidazoleexperimentalPhase 4451-17-25798
2AnthelminticsPhase 4363

Interventional clinical trials:

idNameStatusNCT IDPhase
1Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With BenzimidazolesRecruitingNCT00658294Phase 4
2Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
3Long-term Results of Comprehensive AE ManagementCompletedNCT02509884
4Epi Cystic Hydatid Disease PeruCompletedNCT00138346
5The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the LiverCompletedNCT01785212
6Parasitic Infections of the Gastrointestinal TractRecruitingNCT00001162

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Echinococcosis

Genetic Tests for Echinococcosis

About this section

Anatomical Context for Echinococcosis

About this section

MalaCards organs/tissues related to Echinococcosis:

33
Liver, Lung, Brain, Heart, Spleen, Kidney, Testes

Animal Models for Echinococcosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Echinococcosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.3CD79A, HLA-B, IFNG, IL10, IL17A, TNF
2MP:00053817.5IFNG, IL10, IL17A, IL5, IL6, TNF
3MP:00053887.3IFNG, IL10, IL17A, IL5, IL6, TNF
4MP:00036316.9CD40LG, CD79A, CD8A, HLA-B, IFNG, IL10
5MP:00053766.2CD40LG, CD79A, IFNG, IL10, IL17A, IL5
6MP:00053975.9CD40LG, CD79A, CD8A, HLA-B, IFNG, IL10
7MP:00053875.3CD40LG, CD79A, CD8A, HLA-B, IFNG, IL10

Publications for Echinococcosis

About this section

Articles related to Echinococcosis:

(show top 50)    (show all 1033)
idTitleAuthorsYear
1
Synchronous adenocarcinoma and echinococcosis in the same ovary: a rare clinical entity. (26435657)
2015
2
Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. (26409727)
2015
3
The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis. (26509179)
2015
4
Surveillance of Human Echinococcosis in Castilla-Leon (Spain) between 2000-2012. (26484764)
2015
5
Development of a cutaneous fistula following hepatic cystic echinococcosis. (26413444)
2015
6
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
7
Laparoscopic approach for total cystectomy in treating hepatic cystic echinococcosis. (25489977)
2014
8
The Production and Comparative Evaluation of Native and Recombinant Antigens for the Fast Serodiagnosis of Cystic Echinococcosis with Dot Immunogold Filtration Assay. (25313824)
2014
9
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
10
A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. (23084536)
2013
11
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
12
Molecular diagnosis of polycystic echinococcosis due to Echinococcus vogeli in a Paraguayan immigrant in Argentina. (23824768)
2013
13
Isolated primary renal echinococcosis: a rare entity. (23435774)
2013
14
High resolution melting technique for molecular epidemiological studies of cystic echinococcosis: differentiating G1, G3, and G6 genotypes of Echinococcus granulosus sensu lato. (23832641)
2013
15
Immunodiagnosis of alveolar echinococcosis using urine samples. (23872436)
2013
16
Ovarian hydatid cyst in pediatric patient commencing as ovarian tumor: a rare site of echinococcosis. (23272291)
2012
17
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
18
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
19
Mapping the increasing risk of human alveolar echinococcosis in Limburg, The Netherlands. (21733269)
2012
20
Development and evaluation of flow through technique for diagnosis of cystic echinococcosis in sheep. (21507576)
2011
21
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
22
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
23
A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom. (21896804)
2011
24
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
25
Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. (21715578)
2011
26
Human echinococcosis: a neglected disease. (20862339)
2010
27
Echinococcosis/hydatidosis: a severe threat in Mediterranean countries. (20888694)
2010
28
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
29
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
30
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
31
Echinococcosis: a review. (18938096)
2009
32
Cardiac echinococcosis of the interventricular septum in early childhood: report of two cases. (19154866)
2009
33
Complications of extrahepatic echinococcosis: fistulization of an adrenal hydatid cyst into the intestine. (18322969)
2008
34
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
35
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
36
Research on targeting sources of alveolar echinococcosis in Japan. (17662388)
2007
37
Stereological evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method. (17105589)
2006
38
Usefulness of severe combined immunodeficiency (scid) and inbred mice for studies of cysticercosis and echinococcosis. (16338168)
2006
39
Comparative evaluation of western blotting in hepatic and pulmonary cystic echinococcosis. (17285854)
2006
40
Brief historical remarks as an introduction for the international symposium on taeniasis/cysticercosis and echinococcosis. (16337830)
2006
41
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
42
HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (14570623)
2003
43
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
44
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
45
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. (10980173)
2000
46
Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. (9875648)
1998
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
49
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989
50
Reactivity of human immunoglobulins in echinococcosis and trichinosis. (4170136)
1968

Variations for Echinococcosis

About this section

Expression for genes affiliated with Echinococcosis

About this section
Search GEO for disease gene expression data for Echinococcosis.

Pathways for genes affiliated with Echinococcosis

About this section

Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD40LG, CD79A, CD8A
29.4CD40LG, IL10, IL5
3
Show member pathways
9.3CD8A, HLA-DRB1, IFNG
49.2IL5, IL6
59.2IFNG, IL10, IL5
69.2CD40LG, CD8A, HLA-B, HLA-DRB1
79.2CD40LG, IFNG, IL5
89.1HLA-B, HLA-DRB1, IFNG, IL10
9
Show member pathways
9.0IFNG, IL10, TNF
10
Show member pathways
8.9CD8A, IFNG, TNF
118.7IL10, IL6, TNF
128.7IL10, IL6, TNF
138.7IFNG, IL5, IL6
14
Show member pathways
8.6IFNG, IL17A, IL6
15
Show member pathways
8.5CD40LG, IFNG, IL5, TNF
168.5IFNG, IL6, TNF
17
Show member pathways
8.5IFNG, IL6, TNF
188.5IFNG, IL6, TNF
198.5IFNG, IL6, TNF
208.5HLA-B, HLA-DRB1, IL6, TNF
21
Show member pathways
8.4CD40LG, HLA-DRB1, IFNG, IL10, TNF
22
Show member pathways
8.4IFNG, IL10, IL5, IL6
238.2IFNG, IL10, IL6, TNF
248.2IFNG, IL10, IL6, TNF
25
Show member pathways
8.0HLA-B, HLA-DRB1, IFNG, IL6, TNF
267.9HLA-DRB1, IFNG, IL10, IL6, TNF
277.9CD8A, HLA-DRB1, IL5, IL6, TNF
287.9CD40LG, IFNG, IL10, IL6, TNF
297.7HLA-DRB1, IFNG, IL17A, IL6, TNF
30
Show member pathways
7.7IFNG, IL10, IL17A, IL6, TNF
31
Show member pathways
7.7IFNG, IL10, IL17A, IL6, TNF
327.5HLA-DRB1, IFNG, IL10, IL5, IL6, TNF
337.4CD40LG, CD79A, CD8A, IFNG, IL10, IL17A
34
Show member pathways
7.4CD40LG, IL10, IL17A, IL5, IL6, TNF
35
Show member pathways
7.0HLA-B, IFNG, IL10, IL17A, IL5, IL6
36
Show member pathways
6.4CD40LG, CD79A, CD8A, HLA-B, HLA-DRB1, IFNG
37
B cell receptor signaling pathway (KEGG)
Show member pathways
6.2CD40LG, CD79A, CD8A, HLA-B, HLA-DRB1, IFNG
38
Show member pathways
5.9CD40LG, CD8A, HLA-B, HLA-DRB1, IFNG, IL10

GO Terms for genes affiliated with Echinococcosis

About this section

Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098976.9CD40LG, CD79A, CD8A, HLA-DRB1, IFNG, IL17A
2extracellular spaceGO:00056156.9CD40LG, IFNG, IL10, IL17A, IL5, IL6

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1detection of bacteriumGO:001604510.6HLA-B, HLA-DRB1
2positive regulation of MHC class II biosynthetic processGO:004534810.3IFNG, IL10
3receptor biosynthetic processGO:003280010.2IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:000274010.2IL10, TNF
5positive regulation of interleukin-23 productionGO:003274710.1IFNG, IL17A
6regulation of immunoglobulin secretionGO:005102310.1CD40LG, TNF
7positive regulation of vitamin D biosynthetic processGO:006055710.1IFNG, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.0IFNG, TNF
9interferon-gamma-mediated signaling pathwayGO:006033310.0HLA-B, HLA-DRB1, IFNG
10positive regulation of podosome assemblyGO:007180310.0IL5, TNF
11B cell differentiationGO:003018310.0CD40LG, CD79A, IL10
12B cell proliferationGO:004210010.0CD40LG, CD79A, IL10
13positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, TNF
14positive regulation of membrane protein ectodomain proteolysisGO:005104410.0IFNG, TNF
15neutrophil apoptotic processGO:00017819.9IFNG, IL6
16positive regulation of immunoglobulin secretionGO:00510249.8IL5, IL6
17epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.7IL6, TNF
18negative regulation of lipid storageGO:00108889.7IL6, TNF
19positive regulation of chemokine productionGO:00327229.7IL6, TNF
20antigen processing and presentationGO:00198829.5CD8A, HLA-B, HLA-DRB1, IFNG
21negative regulation of growth of symbiont in hostGO:00441309.5IFNG, IL10, TNF
22defense response to protozoanGO:00428329.3IFNG, IL10, IL6
23positive regulation of JAK-STAT cascadeGO:00464279.3IL10, IL5, IL6
24positive regulation of osteoclast differentiationGO:00456729.2IFNG, IL17A, TNF
25response to glucocorticoidGO:00513849.2IL10, IL6, TNF
26humoral immune responseGO:00069599.1IFNG, IL6, TNF
27regulation of immune responseGO:00507768.9CD40LG, CD8A, HLA-B, IFNG
28positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.8IL10, IL5, IL6, TNF
29positive regulation of nitric oxide biosynthetic processGO:00454298.7IFNG, IL6, TNF
30cellular response to lipopolysaccharideGO:00712228.5IFNG, IL10, IL6, TNF
31agingGO:00075688.4IL10, IL6, MT-ATP6, MT-CO1
32cell surface receptor signaling pathwayGO:00071668.3CD79A, CD8A, IFNG, IL17A, TNF
33cytokine-mediated signaling pathwayGO:00192218.1HLA-B, HLA-DRB1, IFNG, IL5, IL6
34positive regulation of transcription, DNA-templatedGO:00458937.9IFNG, IL10, IL5, IL6, TNF
35inflammatory responseGO:00069547.7CD40LG, IL10, IL17A, IL5, IL6, TNF
36immune responseGO:00069556.2CD40LG, CD8A, HLA-B, HLA-DRB1, IFNG, IL10

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051256.9CD40LG, IFNG, IL10, IL17A, IL5, IL6

Sources for Echinococcosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet