MCID: ECH003
MIFTS: 63

Echinococcosis malady

Infectious diseases, Liver diseases categories

Summaries for Echinococcosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards: Echinococcosis, also known as hydatidosis, is related to hepatitis and thyroiditis. An important gene associated with Echinococcosis is MT-CO1 (mitochondrially encoded cytochrome c oxidase I), and among its related pathways are Primary immunodeficiency and COPII (Coat Protein 2) Mediated Vesicle Transport. The drug albendazole and the compounds solium and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are hematopoietic system and cellular.

CDC:3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia:63 Echinococcosis, also called hydatid disease, hydatidosis, or echinococcal disease, is a parasitic... more...

Aliases & Classifications for Echinococcosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hydatidosis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

echinococcosis 8 10 60
hydatidosis 8 42 48
echinococcosis, unspecified, of liver 8
liver echinococcus unspecified 8
echinococcosis, pulmonary 60
pulmonary echinococcosis 8
echinococcosis of liver 8
echinococcosis, hepatic 60
hepatic echinococcosis 8
echinococcal disease 8
hydatid disease 8
hydatids 44


External Ids:

Disease Ontology8 DOID:1496
MeSH34 D004443
NCIt39 C84682
ICD9CM27 122
MESH via Orphanet35 D004443
SNOMED-CT via Orphanet57 74942003
UMLS via Orphanet61 C0013502
ICD10 via Orphanet26 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
ICD1025 B67, B67.8

Related Diseases for Echinococcosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Echinococcosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.2HLA-B
2thyroiditis29.8HLA-DRB1
3pancreatitis29.8IL10
4arthritis29.8TAP2, IL10, HLA-DRB1, HLA-B
5tuberculosis29.8HLA-DQB1, IL10, HLA-DRB1, KLRK1, IL12B
6hepatocellular carcinoma29.8TAP2, TAP1, PRDX4, HLA-DRB1, KLRK1
7breast cancer29.8HLA-B, TSPAN32, PRDX4, TAP1, TAP2
8rheumatoid arthritis29.8TSPAN32, IL12B, IL10, HLA-DRB1, HLA-DRB5, HLA-DQB1
9colon cancer29.7TSPAN32, MT-CO1, TAP1
10cystic echinococcosis11.2
11alveolar echinococcosis11.2
12polycystic echinococcosis10.5
13cysticercosis10.5
14hepatitis a10.4
15cerebritis10.4
16taeniasis10.4
17liver disease10.3
18peritonitis10.3
19choledochal cyst10.2
20pulmonary embolism10.2
21cardiac tamponade10.1
22acute pancreatitis10.1
23horner's syndrome10.1
24aspergillosis10.1
25liver sarcoma10.1
26sarcoma10.1
27obstructive jaundice10.1
28acute cholangitis10.1
29cholangitis10.1
30pericarditis10.1
31ovarian cyst10.0
32bronchiectasis10.0TAP2
33pemphigus vulgaris10.0HLA-DRB1
34measles10.0IL12B
35leishmaniasis10.0IL10
36pemphigus foliaceus10.0HLA-DRB1
37vaccinia10.0HLA-B
38vogt-koyanagi-harada disease10.0HLA-DRB1
39galactosemia10.0IL10
40viral hepatitis10.0HLA-DRB1
41dermatomyositis10.0HLA-B
42leprosy10.0HLA-DRB1
43deficiency anemia10.0HLA-B
44sjogren's syndrome10.0TAP2, TAP1
45ovarian cancer10.0TAP2
46celiac disease10.0HLA-DQB1, KLRK1
47common variable immune deficiency10.0IL10
48aphthous stomatitis10.0HLA-B
49polymyositis10.0HLA-B
50paracoccidioidomycosis10.0IL10

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to echinococcosis

Clinical Features for Echinococcosis

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Drugs & Therapeutics for Echinococcosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Echinococcosis

Drug clinical trials:

Search ClinicalTrials for Echinococcosis

Search NIH Clinical Center for Echinococcosis

Search CenterWatch for Echinococcosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Echinococcosis

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Anatomical Context for Echinococcosis

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32MalaCards
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MalaCards organs/tissues related to Echinococcosis:

32
Liver, Brain, Lung, Heart, Spleen, Kidney, Testes, Bone, Skin, T cells, Breast, Pancreas, Adrenal gland, Colon, Spinal cord, Thyroid, Temporal lobe, Skeletal muscle, Testis, Prostate, Tongue

Animal Models for Echinococcosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Echinococcosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.7HLA-DQB1, HLA-B, CD8A, IL10, IL12B, TAP1
2MP:00053849.4TSPAN32, KLRK1, HLA-DQB1, HLA-B, MT-CO1, PRDX4
3MP:00053879.3MT-CO1, HLA-B, HLA-DQB1, KLRK1, CD8A, IL10

Publications for Echinococcosis

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Sources:
50PubMed
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Articles related to Echinococcosis:

(show top 50)    (show all 924)
idTitleAuthorsYear
1
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
2
A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. (23546806)
2013
3
eComment. Alveolar echinococcosis of the lung. (23400540)
2013
4
Treatment challenges associated with bone echinococcosis. (24222611)
2013
5
Primary alveolar echinococcosis (Echinococcus multilocularis) of the adrenal gland: report of two cases. (23769454)
2013
6
Chemotherapy in alveolar echinococcosis of multi-organs: what's the role? (23508760)
2013
7
Polycystic echinococcosis in the state of Acre, Brazil: contribution to patient diagnosis, treatment and prognosis. (23903966)
2013
8
Alveolar echinococcosis-spreading disease challenging clinicians: a case report and literature review. (23864792)
2013
9
Echinococcus granulosus genotype G1 dominated in cattle and sheep during 2003-2006 in Buenos Aires province, an endemic area for cystic echinococcosis in Argentina. (23632259)
2013
10
Primary echinococcosis of the chest wall. (24148841)
2013
11
A retrospective study on burden of human echinococcosis based on Hospital Discharge Records from 2001 to 2009 in Sardinia, Italy. (22634205)
2012
12
Rheumatoid arthritis, alveolar echinococcosis, and rituximab: a case report. (22154698)
2012
13
A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: Vaccine efficacy and immunology. (22479658)
2012
14
Comparison of the usefulness of hydatid cyst fluid, native antigen B and recombinant antigen B8/1 for serological diagnosis of cystic echinococcosis. (22472966)
2012
15
Inclusion of predeposit autologous blood donation and 33 % hypertonic saline solution in the surgical management of patients with peritoneal echinococcosis. (22538394)
2012
16
Diagnosing and staging of cystic echinococcosis: how do CT and MRI perform in comparison to ultrasound? (23145199)
2012
17
Echinococcosis in sub-Saharan Africa: emerging complexity. (21561714)
2011
18
A serological survey of cystic echinococcosis in equids in East of Turkey. (22347313)
2011
19
Economic impact of cystic echinococcosis in peru. (21629731)
2011
20
Cystic echinococcosis of lung and heart coupled with repeated echinococcosis of brain--a case report. (22397279)
2011
21
Distribution of HLA specificity frequencies in patients with cystic echinococcosis]. (22308705)
2011
22
Pediatric alveolar echinococcosis invading the diaphragm and spreading to the chest and abdominal wall. (20152332)
2010
23
Cystic echinococcosis in children - the seventeen-year experience of two large medical centers in Serbia. (20206293)
2010
24
Pathology quiz case 1. Sino-orbital cystic echinococcosis (CE). (19841351)
2009
25
Evaluation of eosinophil cationic protein levels with clinical symptoms and laboratory findings of patients with cystic echinococcosis]. (19621614)
2009
26
Emergence of polycystic neotropical echinococcosis. (18258123)
2008
27
Echinococcosis granulosus/hydatidosis an endemic zoonotic disease in Egypt. (17985592)
2007
28
Taeniasis, cysticercosis and echinococcosis in Thailand. (16338166)
2006
29
Orthotopic liver transplantation for incurable alveolar echinococcosis: report of five cases from west China. (15964373)
2005
30
An epidemiological and biomolecular survey of cystic echinococcosis in cattle in Sardinia. (16044715)
2004
31
Cytokine expression in the follow-up of patients with cystic echinococcosis. (16044714)
2004
32
Surgical treatment of multiple cystic echinococcosis. (18333060)
2004
33
Cystic echinococcosis in the Campania region (southern Italy). (16044717)
2004
34
Cystic echinococcosis in Jordan: socioeconomic evaluation and risk factors. (12774228)
2003
35
Identification of a gene engineering antibody against cystic echinococcosis in liver. (14599944)
2003
36
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
37
Survey on cystic echinococcosis in Tibetans, West China. (12039679)
2002
38
Secondary renal involvement in human cystic echinococcosis: a review of the literature and report of another case. (12537637)
2002
39
Prevalence, intensity, and fertility of ovine cystic echinococcosis in the central Peruvian Andes. (11579878)
2001
40
Molecular tools for the diagnosis of cystic and alveolar echinococcosis. (11422961)
2001
41
Estimating the economic effects of cystic echinococcosis. Part 2: an endemic region in the United Kingdom, a wealthy, industrialized economy. (11299124)
2001
42
A new therapeutic approach for the treatment of cystic echinococcosis: percutaneous albendazole sulphoxide injection without reaspiration. (10638592)
2000
43
Short report: An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus-specific DNA sequences. (9660465)
1998
44
Disseminated intracerebral alveolar echinococcosis: CT and MRI. (9225324)
1997
45
Alveolar echinococcosis. (7657269)
1995
46
Serological differentiation between cystic and alveolar echinococcosis by use of recombinant larval antigens. (8308113)
1993
47
Chemotherapy of human cystic echinococcosis: comparative efficacy of mebendazole and albendazole. (1616396)
1992
48
Specific cellular and humoral immune responses in patients with different long-term courses of alveolar echinococcosis (infection with Echinococcus multilocularis). (1763801)
1991
49
Cellular immune response in Echinococcus multilocularis infection in humans. II. Natural killer cell activity and cell subpopulations in the blood and in the periparasitic granuloma of patients with alveolar echinococcosis. (2805425)
1989
50
Operative treatment of alveolar echinococcosis of the liver. (651023)
1978

Genetic Variations for Echinococcosis

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Expression for genes affiliated with Echinococcosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Echinococcosis

Search GEO for disease gene expression data for Echinococcosis.

Pathways for genes affiliated with Echinococcosis

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Echinococcosis according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD8A, TAP1
2
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10.3HLA-B, TAP1, TAP2
310.2HLA-DQB1, HLA-DRB5, HLA-DRB1
4
Hide members
10.2HLA-DQB1, HLA-DRB5, HLA-DRB1
5
Immune response Antigen presentation by MHC class II
Hide members
10.2HLA-DQB1, HLA-DRB5, HLA-DRB1
6
Immune response ICOS pathway in T-helper cell
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10.2HLA-DQB1, HLA-DRB5, HLA-DRB1
710.2HLA-DRB1, HLA-DRB5, HLA-DQB1
810.2HLA-DRB1, HLA-DRB5, HLA-DQB1
9
Immune response NFAT in immune response
Hide members
10.2HLA-DRB1, HLA-DRB5, HLA-DQB1
10
Hide members
10.2HLA-DRB1, HLA-DRB5, HLA-DQB1
1110.2IL12B, IL10, HLA-DRB1
12
Hide members
10.2IL12B, CD8A, HLA-DRB1
1310.2CD8A, HLA-DRB1, HLA-DRB5
1410.2TAP2, TAP1, CD8A, HLA-B
1510.2CD8A, IL10, TAP1, TAP2
1610.1HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
17
Hide members
10.1HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
18
Hide members
10.1HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
1910.1IL10, HLA-DRB1, HLA-DRB5, HLA-DQB1
20
Hide members
10.1HLA-DQB1, HLA-DRB5, HLA-DRB1, IL10
21
Hide members
10.1CD8A, HLA-DRB1, HLA-DRB5, HLA-DQB1
22
Hide members
10.1HLA-DQB1, HLA-DRB5, HLA-DRB1, CD8A
2310.1HLA-DQB1, HLA-DRB5, HLA-DRB1, IL12B
2410.1HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, IL10
2510.1HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, CD8A
2610.0HLA-DQB1, HLA-DRB5, HLA-DRB1, IL10, IL12B
27
Hide members
10.0HLA-DQB1, HLA-DRB5, HLA-DRB1, IL10, IL12B
2810.0HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, TAP1, TAP2
29
Hide members
9.9HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, CD8A, IL10
30
Hide members
9.8KLRK1, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, CD8A
31
Hide members
9.8EEF1D, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, IL12B

Compounds for genes affiliated with Echinococcosis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Echinococcosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1solium4410.4MT-CO1, MT-ATP6, HLA-B
2glatiramer acetate44 1111.3IL10, HLA-DRB1
3polyinosinic-polycytidylic acid4410.2KLRK1, HLA-B, IL10, IL12B
4lipoteichoic acid4410.1HLA-B, IL10, IL12B
5atp44 2810.9HLA-B, HLA-DRB1, MT-ATP6, MT-CO1, PRDX4, TAP1
6il 10449.9IL12B, IL10, CD8A

GO Terms for genes affiliated with Echinococcosis

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16Gene Ontology
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Cellular components related to Echinococcosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.4HLA-DQB1, HLA-DRB5, HLA-DRB1
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.4HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:03066910.4HLA-DRB1, HLA-DRB5, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:01250710.3HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
5TAP complexGO:04282510.3TAP2, TAP1
6transport vesicle membraneGO:03065810.3HLA-DRB1, HLA-DRB5, HLA-DQB1
7trans-Golgi network membraneGO:03258810.3HLA-DQB1, HLA-DRB5, HLA-DRB1
8endocytic vesicle membraneGO:03066610.1HLA-DRB1, HLA-DRB5, HLA-DQB1
9lysosomal membraneGO:00576510.1RRAGB, HLA-DRB1, HLA-DRB5, HLA-DQB1
10membraneGO:0160209.6HLA-DQB1, HLA-B, HLA-DRB1, IL12B, SLC4A3, PTDSS1

Biological processes related to Echinococcosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.7TAP1, TAP2
2intracellular transport of viral proteins in host cellGO:01906010.6TAP2, TAP1
3peptide transportGO:01583310.6TAP1, TAP2
4negative regulation of myeloid dendritic cell activationGO:03088610.6IL10, TSPAN32
5regulation of interleukin-10 secretionGO:200117910.6HLA-DRB5, HLA-DRB1
6immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.6HLA-DRB1, HLA-DRB5, HLA-DQB1
7antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.6TAP2, TAP1
8regulation of interleukin-4 productionGO:03267310.6HLA-DRB5, HLA-DRB1
9humoral immune response mediated by circulating immunoglobulinGO:00245510.6HLA-DQB1, HLA-DRB5, HLA-DRB1
10detection of bacteriumGO:01604510.6HLA-B, HLA-DRB5, HLA-DRB1
11negative regulation of interferon-gamma productionGO:03268910.6IL10, HLA-DRB1, HLA-DRB5
12T-helper 1 type immune responseGO:04208810.6IL12B, HLA-DRB1, HLA-DRB5
13negative regulation of T cell proliferationGO:04213010.5IL10, HLA-DRB1, HLA-DRB5
14positive regulation of T cell mediated cytotoxicityGO:00191610.5TAP2, TAP1, IL12B, HLA-B
15interferon-gamma-mediated signaling pathwayGO:06033310.5HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.5TAP2, TAP1, HLA-B
17T cell costimulationGO:03129510.4HLA-DRB1, HLA-DRB5, HLA-DQB1
18antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4HLA-B, TAP1, TAP2
19cytokine-mediated signaling pathwayGO:01922110.4HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
20T cell receptor signaling pathwayGO:05085210.4HLA-DRB1, HLA-DRB5, HLA-DQB1
21immune responseGO:00695510.4CD8A, HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
22antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.3HLA-DRB1, HLA-DRB5, HLA-DQB1
23antigen processing and presentation of peptide antigen via MHC class IGO:00247410.3HLA-B, TAP1, TAP2
24inflammatory response to antigenic stimulusGO:00243710.3HLA-DRB1, HLA-DRB5
25defense response to protozoanGO:04283210.3TSPAN32, IL12B
26positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:03577410.2HLA-DRB1, HLA-DRB5
27negative regulation of growth of symbiont in hostGO:04413010.0IL12B, IL10

Molecular functions related to Echinococcosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.5TAP1, TAP2
2peptide transporter activityGO:01519710.4TAP1, TAP2
3MHC class I protein bindingGO:04228810.4CD8A, TAP1, TAP2
4TAP2 bindingGO:04697910.3TAP1, TAP2
5MHC class II receptor activityGO:03239510.3HLA-DRB1, HLA-DQB1
6peptide antigen bindingGO:04260510.3TAP2, TAP1, HLA-DRB1, HLA-DRB5, HLA-B
7TAP1 bindingGO:04697810.2TAP1, TAP2
8oligopeptide-transporting ATPase activityGO:01542110.0TAP1, TAP2

Products for genes affiliated with Echinococcosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Echinococcosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet