MCID: ECH003
MIFTS: 59

Echinococcosis malady

Rare diseases, Infectious diseases, Liver diseases categories
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Summaries for Echinococcosis

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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary: Echinococcosis, also known as echinococcosis of liver, is related to hepatitis and arthritis. An important gene associated with Echinococcosis is MT-CO1 (mitochondrially encoded cytochrome c oxidase I), and among its related pathways are ABC-family proteins mediated transport and Primary immunodeficiency. The drug albendazole and the compounds solium and lapatinib have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotype immune system.

CDC:3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia:65 Echinococcosis, also called hydatid disease, hydatidosis, or echinococcal disease, is a parasitic... more...

Aliases & Classifications for Echinococcosis

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Echinococcosis, Aliases & Descriptions:

Name: Echinococcosis 8 10 62
Echinococcosis of Liver 8 62
Hydatid Disease 8 62
Hydatidosis 8 42
Echinococcosis, Unspecified, of Liver 8
Liver Echinococcus Unspecified 8
 
Echinococcosis, Pulmonary 62
Pulmonary Echinococcosis 8
Echinococcosis, Hepatic 62
Hepatic Echinococcosis 8
Echinococcal Disease 8
Hydatids 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Liver diseases


External Ids:

Disease Ontology8 DOID:1496
ICD9CM27 122
MeSH34 D004443
NCIt39 C84682
ICD1025 B67, B67.8

Related Diseases for Echinococcosis

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Diseases related to Echinococcosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.5TAP2, HLA-DRB1
2arthritis29.8TAP2, HLA-DRB1, HLA-B
3breast cancer29.7TAP2, HLA-B, TAP1
4rheumatoid arthritis29.5HLA-DQB1, HLA-DRB1, TAP2
5cystic echinococcosis11.3
6alveolar echinococcosis11.2
7cysticercosis10.6
8polycystic echinococcosis10.6
9cerebritis10.5
10taeniasis10.5
11narcolepsy10.4HLA-DRB1
12peritonitis10.3
13celiac disease10.3HLA-DQB1
14choledochal cyst10.3
15cardiac tamponade10.2
16pulmonary embolism10.2
17reactive arthritis10.2HLA-B, TAP2
18sjogren's syndrome10.1TAP2, TAP1
19acute pancreatitis10.1
20acute cholangitis10.1
21cholangitis10.1
22pericarditis10.1
23bronchogenic cyst10.1
24plasmodium falciparum malaria10.1HLA-B, HLA-DRB1
25horner's syndrome10.1
26aspergillosis10.1
27sarcoma10.1
28toxocariasis10.1
29allergic rhinitis10.1TAP1, TAP2
30primary biliary cirrhosis10.1HLA-B, HLA-DRB1
31multiple sclerosis 110.1HLA-DQB1, HLA-DRB1
32nasopharynx carcinoma10.0TAP1, HLA-B
33colorectal cancer10.0TAP2, TAP1
34burkitt's lymphoma10.0TAP1, TAP2
35exophthalmos10.0
36parovarian cyst10.0
37portal hypertension10.0
38cystadenocarcinoma10.0
39meningitis10.0
40paraplegia10.0
41pleural empyema10.0
42urticaria10.0
43juvenile rheumatoid arthritis10.0HLA-DQB1, HLA-DRB1
44pulmonary tuberculosis10.0HLA-DRB1, HLA-DQB1
45autoimmune hepatitis10.0HLA-DQB1, HLA-DRB1
46hepatitis b10.0HLA-DRB1, HLA-DQB1
47pleuropneumonia10.0
48obstructive jaundice10.0
49strongyloidiasis10.0
50paragonimiasis10.0

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to echinococcosis

Symptoms for Echinococcosis

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Drugs & Therapeutics for Echinococcosis

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Drug clinical trials:

Search ClinicalTrials for Echinococcosis

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Echinococcosis

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Anatomical Context for Echinococcosis

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MalaCards organs/tissues related to Echinococcosis:

32
Liver, Brain, Lung, Heart, Spleen, Kidney, Testes, Bone, Skin, Pancreas, Breast, T cells, Spinal cord, Colon, Adrenal gland, Skeletal muscle, Thyroid, Prostate, Testis, Temporal lobe, Tongue

Animal Models for Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Echinococcosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6TAP2, TAP1, MT-CO1, HLA-DQB1, HLA-B

Publications for Echinococcosis

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Articles related to Echinococcosis:

(show top 50)    (show all 955)
idTitleAuthorsYear
1
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
2
MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep. (24782918)
2014
3
The Production and Comparative Evaluation of Native and Recombinant Antigens for the Fast Serodiagnosis of Cystic Echinococcosis with Dot Immunogold Filtration Assay. (25313824)
2014
4
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
5
A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. (23084536)
2013
6
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
7
Molecular diagnosis of polycystic echinococcosis due to Echinococcus vogeli in a Paraguayan immigrant in Argentina. (23824768)
2013
8
Isolated primary renal echinococcosis: a rare entity. (23435774)
2013
9
High resolution melting technique for molecular epidemiological studies of cystic echinococcosis: differentiating G1, G3, and G6 genotypes of Echinococcus granulosus sensu lato. (23832641)
2013
10
Immunodiagnosis of alveolar echinococcosis using urine samples. (23872436)
2013
11
Ovarian hydatid cyst in pediatric patient commencing as ovarian tumor: a rare site of echinococcosis. (23272291)
2012
12
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
13
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
14
Mapping the increasing risk of human alveolar echinococcosis in Limburg, The Netherlands. (21733269)
2012
15
Development and evaluation of flow through technique for diagnosis of cystic echinococcosis in sheep. (21507576)
2011
16
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
17
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
18
A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom. (21896804)
2011
19
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
20
Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. (21715578)
2011
21
Human echinococcosis: a neglected disease. (20862339)
2010
22
Echinococcosis/hydatidosis: a severe threat in Mediterranean countries. (20888694)
2010
23
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
24
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
25
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
26
Echinococcosis: a review. (18938096)
2009
27
Cardiac echinococcosis of the interventricular septum in early childhood: report of two cases. (19154866)
2009
28
Complications of extrahepatic echinococcosis: fistulization of an adrenal hydatid cyst into the intestine. (18322969)
2008
29
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
30
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
31
Research on targeting sources of alveolar echinococcosis in Japan. (17662388)
2007
32
Stereological evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method. (17105589)
2006
33
Usefulness of severe combined immunodeficiency (scid) and inbred mice for studies of cysticercosis and echinococcosis. (16338168)
2006
34
Comparative evaluation of western blotting in hepatic and pulmonary cystic echinococcosis. (17285854)
2006
35
Brief historical remarks as an introduction for the international symposium on taeniasis/cysticercosis and echinococcosis. (16337830)
2006
36
Ultrasound wall-sign in pulmonary echinococcosis (new application). (17160760)
2006
37
Echinococcus granulosus cattle strain identification in an autochthonous case of cystic echinococcosis in central Mexico. (15533292)
2004
38
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
39
HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (14570623)
2003
40
European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000. (12643830)
2003
41
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
42
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
43
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. (10980173)
2000
44
Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. (9875648)
1998
45
Short report: An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus-specific DNA sequences. (9660465)
1998
46
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
47
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
48
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989
49
Cultural factors in the transmission of echinococcosis and sparganosis in the Masai of East Africa. (4437214)
1974
50
Reactivity of human immunoglobulins in echinococcosis and trichinosis. (4170136)
1968

Variations for Echinococcosis

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Expression for genes affiliated with Echinococcosis

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Expression patterns in normal tissues for genes affiliated with Echinococcosis

Search GEO for disease gene expression data for Echinococcosis.

Pathways for genes affiliated with Echinococcosis

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Pathways related to Echinococcosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TAP2, TAP1
29.5TAP1, TAP2
39.3TAP1, HLA-B
4
Show member pathways
9.1HLA-DRB1, HLA-DQB1
59.1HLA-DQB1, HLA-DRB1
69.1HLA-DRB1, HLA-DQB1
79.1HLA-DRB1, HLA-DQB1
8
Show member pathways
9.1HLA-DRB1, HLA-DQB1
9
Show member pathways
9.1HLA-DRB1, HLA-DQB1
10
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1HLA-DQB1, HLA-DRB1
11
Show member pathways
9.1HLA-DRB1, HLA-DQB1
12
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.9TAP2, TAP1, HLA-B
13
Show member pathways
8.9TAP2, TAP1, HLA-B
148.5HLA-DRB1, HLA-DQB1, HLA-B
158.5HLA-B, HLA-DQB1, HLA-DRB1
168.5HLA-B, HLA-DQB1, HLA-DRB1
17
Show member pathways
8.5HLA-DRB1, HLA-DQB1, HLA-B
18
Show member pathways
8.5HLA-DRB1, HLA-DQB1, HLA-B
19
Show member pathways
7.5TAP2, TAP1, HLA-DRB1, HLA-DQB1, HLA-B
207.5TAP2, TAP1, HLA-DRB1, HLA-DQB1, HLA-B
21
Show member pathways
7.5HLA-B, HLA-DQB1, HLA-DRB1, TAP1, TAP2
22
Show member pathways
7.5HLA-B, HLA-DQB1, HLA-DRB1, TAP1, TAP2

Compounds for genes affiliated with Echinococcosis

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Echinococcosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1solium449.6MT-CO1, HLA-B
2lapatinib44 50 1111.5HLA-DRB1, TAP1
3mitoxantrone44 50 1111.4TAP1, TAP2
4ecori449.1HLA-DQB1, HLA-B
5alanine449.0TAP2, TAP1, HLA-DRB1
6glutamine448.7TAP2, TAP1, HLA-DQB1
7glutamate448.3TAP1, HLA-DRB1, HLA-DQB1
8atp44 289.1HLA-B, HLA-DRB1, MT-CO1, TAP1, TAP2
9oligonucleotide447.7TAP2, TAP1, HLA-DRB1, HLA-DQB1, HLA-B

GO Terms for genes affiliated with Echinococcosis

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Cellular components related to Echinococcosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.7TAP1, TAP2
2MHC class II protein complexGO:0426139.3HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DRB1, HLA-DQB1
4transport vesicle membraneGO:0306589.3HLA-DRB1, HLA-DQB1
5trans-Golgi network membraneGO:0325889.2HLA-DQB1, HLA-DRB1
6integral component of endoplasmic reticulum membraneGO:0301769.2TAP2, TAP1
7endocytic vesicle membraneGO:0306669.1HLA-DRB1, HLA-DQB1
8integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.8HLA-DRB1, HLA-DQB1, HLA-B
9ER to Golgi transport vesicle membraneGO:0125078.7HLA-DRB1, HLA-DQB1, HLA-B
10membraneGO:0160208.5HLA-DRB1, HLA-DQB1, HLA-B
11Golgi membraneGO:0001398.4HLA-B, HLA-DQB1, HLA-DRB1
12plasma membraneGO:0058867.6TAP2, TAP1, HLA-DRB1, HLA-DQB1, HLA-B

Biological processes related to Echinococcosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:0469679.8TAP2, TAP1
2oligopeptide transmembrane transportGO:0356729.8TAP1, TAP2
3intracellular transport of viral protein in host cellGO:0190609.8TAP2, TAP1
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:0198859.8TAP2, TAP1
5peptide transportGO:0158339.7TAP2, TAP1
6detection of bacteriumGO:0160459.5HLA-DRB1, HLA-B
7immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.4HLA-DRB1, HLA-DQB1
8defense responseGO:0069529.3TAP1, HLA-B
9humoral immune response mediated by circulating immunoglobulinGO:0024559.3HLA-DQB1, HLA-DRB1
10positive regulation of T cell mediated cytotoxicityGO:0019169.2TAP2, TAP1, HLA-B
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.2HLA-B, TAP1, TAP2
12antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.2TAP2, TAP1, HLA-B
13antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.1HLA-DRB1, HLA-DQB1
14antigen processing and presentation of peptide antigen via MHC class IGO:0024749.1HLA-B, TAP1, TAP2
15T cell costimulationGO:0312959.0HLA-DQB1, HLA-DRB1
16T cell receptor signaling pathwayGO:0508528.8HLA-DRB1, HLA-DQB1
17interferon-gamma-mediated signaling pathwayGO:0603338.8HLA-DRB1, HLA-DQB1, HLA-B
18cytokine-mediated signaling pathwayGO:0192218.6HLA-B, HLA-DQB1, HLA-DRB1
19immune responseGO:0069558.6HLA-DRB1, HLA-DQB1, HLA-B

Molecular functions related to Echinococcosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:0469809.7TAP1, TAP2
2MHC class Ib protein bindingGO:0230299.6TAP1, TAP2
3peptide transporter activityGO:0151979.6TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:0154219.6TAP1, TAP2
5TAP1 bindingGO:0469789.5TAP2, TAP1
6MHC class I protein bindingGO:0422889.5TAP2, TAP1
7TAP2 bindingGO:0469799.4TAP2, TAP1
8MHC class II receptor activityGO:0323958.8HLA-DRB1, HLA-DQB1
9peptide antigen bindingGO:0426058.6TAP2, TAP1, HLA-DRB1, HLA-B

Products for genes affiliated with Echinococcosis

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  • Antibodies
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Sources for Echinococcosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet