MCID: ECH003
MIFTS: 57

Echinococcosis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Echinococcosis

MalaCards integrated aliases for Echinococcosis:

Name: Echinococcosis 12 3 41 14 69
Hydatidosis 12 72 49
Echinococcosis, Unspecified, of Liver 12
Liver Echinococcus Unspecified 12
Echinococcosis, Pulmonary 69
Pulmonary Echinococcosis 12
Echinococcosis of Liver 12
Echinococcosis, Hepatic 69
Hepatic Echinococcosis 12
Echinococcal Disease 12
Hydatid Disease 12
Hydatids 51

Classifications:



External Ids:

Disease Ontology 12 DOID:1496
ICD10 32 B67 B67.90 B67.8
ICD9CM 34 122
MeSH 41 D004443
NCIt 46 C84682

Summaries for Echinococcosis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary : Echinococcosis, also known as hydatidosis, is related to alveolar echinococcosis and cystic echinococcosis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Metronidazole and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are hematopoietic system and immune system

CDC : 3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia : 72 Echinococcosis is a parasitic disease of tapeworms of the Echinococcus type. The two main types of the... more...

Related Diseases for Echinococcosis

Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)
# Related Disease Score Top Affiliating Genes
1 alveolar echinococcosis 33.4 CCL17 HLA-B HLA-DRB1 MT-CO1 TNF
2 cystic echinococcosis 31.8 CD40LG CES1 HLA-DRB1 IL10 IL17A MT-ATP6
3 cysticercosis 30.4 IL6 MT-CO1 MT-ND1
4 peritonitis 29.9 IFNG IL10 IL6 TNF
5 immune suppression 29.9 IFNG IL10 IL6
6 amebiasis 29.9 CD40LG CD79A IL17A
7 myeloma, multiple 29.8 CD40LG CD79A IL6
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.7 IFNG IL10 IL17A
9 prostatitis 29.7 IL10 IL6 TNF
10 taeniasis 29.6 CD40LG CD79A IL10 MT-CO1 MT-ND1
11 mycobacterium tuberculosis 1 29.4 IFNG IL10 IL17A TNF
12 allergic hypersensitivity disease 29.0 CCL17 IFNG IL10 IL5
13 pneumonia 28.9 CD40LG IL10 IL5 IL6 TNF
14 colitis 28.8 IFNG IL10 IL17A IL6 TNF
15 toxoplasmosis 28.7 CD40LG CD79A IFNG IL10 IL6 TNF
16 arthritis 28.6 HLA-DRB1 IFNG IL10 IL17A IL6 TNF
17 schistosomiasis 28.5 CD40LG CD79A IFNG IL10 IL5 TNF
18 acquired immunodeficiency syndrome 28.4 CD40LG CD79A HLA-B IFNG IL10 IL6
19 rheumatoid arthritis 27.7 CD40LG CD79A HLA-B HLA-DRB1 IFNG IL10
20 malaria 27.2 CD40LG HLA-B HLA-DRB1 IFNG IL10 IL17A
21 polycystic echinococcosis 12.3
22 cardiac hydatid cysts with intracavitary expansion 11.9
23 hepatitis 10.7
24 postherpetic neuralgia 10.6 HLA-B HLA-DRB1
25 selective igg deficiency disease 10.5 CD40LG CD79A
26 c1q nephropathy 10.5 CD40LG CD79A
27 idiopathic inflammatory myopathy 10.5 HLA-B HLA-DRB1
28 juvenile myasthenia gravis 10.5 HLA-DRB1 IL10
29 meningovascular neurosyphilis 10.5 CD40LG CD79A
30 alpha chain disease 10.5 CD40LG CD79A
31 brill-zinsser disease 10.5 CD40LG CD79A
32 exudative glomerulonephritis 10.5 CD40LG CD79A
33 cork-handlers' disease 10.5 CD40LG CD79A
34 salpingo-oophoritis 10.5 CD40LG CD79A
35 early yaws 10.5 CD40LG CD79A
36 ventilation pneumonitis 10.5 CD40LG CD79A
37 chronic interstitial cystitis 10.5 CD40LG CD79A
38 axillary adenitis 10.5 CD40LG CD79A
39 cryofibrinogenemia 10.5 CD40LG CD79A
40 trichostrongyloidiasis 10.5 CD40LG CD79A
41 subacute bacterial endocarditis 10.5 CD40LG CD79A
42 heterophyiasis 10.5 CD40LG CD79A
43 immunoglobulin g deficiency 10.5 CD40LG CD79A
44 orbital granuloma 10.5 CD40LG CD79A
45 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
46 hyperglobulinemic purpura 10.5 CD40LG CD79A
47 gastroduodenitis 10.5 CD40LG CD79A
48 bacterial conjunctivitis 10.5 CD40LG CD79A
49 neuroschistosomiasis 10.5 CD79A IFNG
50 ross river fever 10.5 CD40LG IL10

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to Echinococcosis

Symptoms & Phenotypes for Echinococcosis

MGI Mouse Phenotypes related to Echinococcosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 IL6 CCL17 TNF CD40LG CD79A IFNG
2 immune system MP:0005387 9.85 MT-CO1 TNF CCL17 CD40LG CD79A IFNG
3 liver/biliary system MP:0005370 9.5 IL6 TNF CD79A CES1 IFNG IL10
4 neoplasm MP:0002006 9.1 IL6 TNF CD79A IFNG IL10 IL5

Drugs & Therapeutics for Echinococcosis

Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Epinephrine Approved, Vet_approved 51-43-4 5816
3 Racepinephrine Approved 329-65-7
4
Albendazole Approved, Vet_approved 54965-21-8 2082
5
Mebendazole Approved, Vet_approved 31431-39-7 4030
6 Benzimidazole Experimental, Investigational 51-17-2
7 Liver Extracts
8 Antiparasitic Agents
9 Anthelmintics
10 Anti-Infective Agents
11 Coagulants
12 Epinephryl borate
13 Hemostatics
14 Antimitotic Agents
15 Antiprotozoal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018
2 Long-term Results of Comprehensive AE Management Completed NCT02509884
3 Epi Cystic Hydatid Disease Peru Completed NCT00138346
4 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
5 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
6 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
7 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359
8 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Benzimidazole
9 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: echinococcosis

Genetic Tests for Echinococcosis

Anatomical Context for Echinococcosis

MalaCards organs/tissues related to Echinococcosis:

38
Liver, Lung, Brain, Heart, Spleen, Kidney, Testes

Publications for Echinococcosis

Articles related to Echinococcosis:

(show top 50) (show all 1220)
# Title Authors Year
1
Ageing impairs parasite-specific antibody responses in cystic echinococcosis. ( 29161459 )
2018
2
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature. ( 29391928 )
2018
3
Knowledge, attitudes and practices related to cystic echinococcosis endemicity in Pakistan. ( 29353554 )
2018
4
eComment. New horizons in diagnosing and managing cardiac echinococcosis. ( 29361169 )
2018
5
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
6
The seroprevalence rate and population genetic structure of human cystic echinococcosis in the Middle East: A systematic review and meta-analysis. ( 29367032 )
2018
7
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
8
Zataria multiflora would attenuate the hepatotoxicity of long-term albendazole treatment in mice with cystic echinococcosis. ( 29196023 )
2018
9
The seroprevalence of cystic echinococcosis in a rural normal population, southwestern Iran. ( 29446749 )
2018
10
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
11
Knowledge, Awareness and Practices Regarding Cystic Echinococcosis among Livestock Farmers in Basrah Province, Iraq. ( 29415425 )
2018
12
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
13
In vivo treatment with IL-17A attenuates hydatid cyst growth and liver fibrogenesis in an experimental model of echinococcosis. ( 29407850 )
2018
14
A retrospective study of human cystic echinococcosis in Basrah province, Iraq. ( 29183851 )
2018
15
Cystic echinococcosis in Turkana, Kenya: 30 years of imaging in an endemic region. ( 29155205 )
2018
16
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
17
Single-center experience in the surgical treatment of combined lung Echinococcosis. ( 29332106 )
2018
18
Genotype characterization of livestock and human cystic echinococcosis in Mazandaran province, Iran. ( 29446344 )
2018
19
A novel in silico minigene vaccine based on CD4<sup>+</sup>T-helper and B-cell epitopes of EG95 isolates for vaccination against cystic echinococcosis. ( 29195784 )
2018
20
Hepatobiliary and Pancreatic: Massive hepatic cystic echinococcosis compressing inferior vena cava. ( 29372607 )
2018
21
Cardio-abdominal echinococcosis: A man with a visible pulsating abdominal mass. ( 29318110 )
2018
22
Cystic echinococcosis in Jordan: A review of causative species, previous studies, serological and radiological diagnosis. ( 29246408 )
2018
23
A Community-Based Study to Estimate the Seroprevalence of Trichinellosis and Echinococcosis in the Roma and Non-Roma Population of Slovakia. ( 29393919 )
2018
24
Ruptured Pulmonary Cystic Echinococcosis Mimicking Tuberculosis in Childhood: A Case Report. ( 28695838 )
2017
25
Trends and correlates of cystic echinococcosis in Chile: 2001-2012. ( 28915247 )
2017
26
Cystic Echinococcosis: A Rare Case of Brain Localization. ( 28761474 )
2017
27
Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis. ( 28457324 )
2017
28
Review of "Echinococcus and Echinococcosis, Part A." edited by R. C. Andrew Thompson, Alan J. Lymbery and Peter Deplazes. ( 28870244 )
2017
29
Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients: Case report. ( 29049181 )
2017
30
Vertebral alveolar echinococcosis-a case report, systematic analysis, and review of the literature. ( 28807628 )
2017
31
Recurrence of cystic echinococcosis in an endemic area: a retrospective study. ( 28655301 )
2017
32
Alveolar echinococcosis presenting with simultaneous cerebral and spinal involvement. ( 28554898 )
2017
33
A T-cell diagnostic test for cystic echinococcosis based on Antigen B peptides. ( 29171068 )
2017
34
Prevalence of and risk factors for cystic echinococcosis among herding families in five provinces in western China: a cross-sectional study. ( 29207667 )
2017
35
Disseminated alveolar echinococcosis resembling metastatic malignancy: a case report. ( 28416007 )
2017
36
To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis. ( 28270242 )
2017
37
Two-stage hepatectomy for multiple giant alveolar echinococcosis. ( 28816980 )
2017
38
Fatal Liver and Lung Alveolar Echinococcosis with Newly Developed Neurologic Symptoms due to the Brain Involvement. ( 28825028 )
2017
39
Primary renal echinococcosis with gross hydatiduria. ( 28838923 )
2017
40
Cystic echinococcosis in South America: a call for action. ( 28902268 )
2017
41
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. ( 28672021 )
2017
42
Expert Reliability for the World Health Organization Standardized Ultrasound Classification of Cystic Echinococcosis. ( 28070008 )
2017
43
Differentiation between hepatic alveolar echinococcosis and primary hepatic malignancy with diffusion-weighted magnetic resonance imaging. ( 29110943 )
2017
44
Cystic echinococcosis in cattle dairy farms: spatial distribution and epidemiological dynamics. ( 28555485 )
2017
45
Surgically managed human cystic echinococcosis in north-eastern Iran: a single center's experience from 2001 to 2008. ( 28848297 )
2017
46
Cystic and alveolar echinococcosis: Successes and continuing challenges. ( 28426657 )
2017
47
Comparison of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance (MR) Imaging to T1 Mapping in Characterization of Hepatic Alveolar Echinococcosis. ( 29259149 )
2017
48
Immunology of cystic echinococcosis (hydatid disease). ( 29253150 )
2017
49
Evaluation of Patients with Cystic Echinococcosis. ( 28483731 )
2017
50
Prevalence of cystic echinococcosis in Iran: a systematic review and meta-analysis. ( 28589871 )
2017

Variations for Echinococcosis

Expression for Echinococcosis

Search GEO for disease gene expression data for Echinococcosis.

Pathways for Echinococcosis

Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CD40LG CD79A HLA-B HLA-DRB1 IFNG IL10
2
Show member pathways
13.63 CCL17 CD40LG IFNG IL10 IL17A IL5
3
Show member pathways
13.49 CCL17 IFNG IL10 IL17A IL5 IL6
4
Show member pathways
13.38 CCL17 CD40LG IL10 IL17A IL5 IL6
5
Show member pathways
13.32 CD40LG HLA-B HLA-DRB1 IFNG IL10 IL17A
6
Show member pathways
13.27 CCL17 CD40LG IL10 IL17A IL5 IL6
7
Show member pathways
12.78 HLA-B HLA-DRB1 IFNG IL6 TNF
8
Show member pathways
12.65 CD40LG CD79A HLA-DRB1 IFNG IL10 TNF
9
Show member pathways
12.59 IFNG IL10 IL17A IL6 TNF
10 12.57 CD40LG CD79A IFNG IL10 IL17A TNF
11
Show member pathways
12.56 HLA-DRB1 IFNG IL10 IL17A IL5 IL6
12
Show member pathways
12.55 CD40LG HLA-B HLA-DRB1 IFNG IL10 IL17A
13
Show member pathways
12.5 IFNG IL10 IL6 TNF
14 12.41 HLA-B HLA-DRB1 IL6 TNF
15
Show member pathways
12.36 IFNG IL10 IL5 IL6
16
Show member pathways
12.36 CD40LG IFNG IL10 IL17A IL5 IL6
17
Show member pathways
12.33 CCL17 IFNG IL17A IL5 IL6 TNF
18 12.29 HLA-B HLA-DRB1 IFNG IL10
19
Show member pathways
12.28 CD40LG HLA-DRB1 IFNG IL10 TNF
20 12.26 HLA-DRB1 IFNG IL10 IL6 TNF
21 12 IL10 IL17A IL6 TNF
22
Show member pathways
11.95 IFNG IL10 IL17A IL6 TNF
23 11.93 HLA-DRB1 IL5 IL6 TNF
24 11.92 IFNG IL10 IL6 TNF
25 11.91 CD79A IFNG IL10 IL5 IL6 TNF
26 11.86 HLA-DRB1 IFNG IL17A IL6 TNF
27
Show member pathways
11.84 IFNG IL17A IL6
28
Show member pathways
11.81 CD40LG IFNG IL5 TNF
29 11.8 IFNG IL10 IL17A IL5 TNF
30 11.79 IFNG IL5 IL6
31 11.79 IFNG IL10 IL6 TNF
32 11.75 IL10 IL6 TNF
33
Show member pathways
11.71 HLA-B IFNG IL10 IL17A IL5 IL6
34 11.7 CCL17 CD40LG IL10 IL5
35
Show member pathways
11.69 CD40LG IFNG IL6 TNF
36 11.67 CD40LG IL10 IL5 IL6 TNF
37 11.66 IL5 IL6 TNF
38 11.56 IFNG IL6 TNF
39 11.54 IL10 IL6 TNF
40 11.53 CCL17 IFNG IL10 IL5
41 11.52 CD40LG IFNG IL10 IL6 TNF
42 11.5 IFNG IL6 TNF
43
Show member pathways
11.39 IFNG IL10 TNF
44 11.39 IFNG IL10 IL6 TNF
45 11.37 IL10 IL6 TNF
46 11.35 CD40LG IFNG IL5
47 11.23 IFNG IL10 IL5
48 11.22 IFNG IL17A IL5 IL6 TNF
49 11.03 CCL17 CD40LG IL10 IL17A IL5 IL6
50 11.02 CCL17 CD40LG IL10 IL17A IL5 IL6

GO Terms for Echinococcosis

Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCL17 CD40LG IFNG IL10 IL17A IL5
2 extracellular space GO:0005615 9.56 CCL17 CD40LG IFNG IL10 IL17A IL5
3 external side of plasma membrane GO:0009897 9.02 CD40LG CD79A HLA-DRB1 IL17A TNF

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.74 HLA-B HLA-DRB1 IFNG
2 B cell differentiation GO:0030183 9.72 CD40LG CD79A IL10
3 response to glucocorticoid GO:0051384 9.71 IL10 IL6 TNF
4 humoral immune response GO:0006959 9.7 IFNG IL6 TNF
5 inflammatory response GO:0006954 9.7 CCL17 CD40LG IL10 IL17A IL5 IL6
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.62 IL10 IL5 IL6 TNF
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
8 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
9 positive regulation of podosome assembly GO:0071803 9.6 IL5 TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL10 TNF
11 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL5 IL6
12 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
13 B cell proliferation GO:0042100 9.58 CD40LG CD79A IL10
14 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
15 regulation of receptor activity GO:0010469 9.56 CCL17 CD40LG IFNG IL10 IL17A IL5
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 IL10 TNF
17 positive regulation of interleukin-23 production GO:0032747 9.49 IFNG IL17A
18 regulation of immunoglobulin secretion GO:0051023 9.48 CD40LG TNF
19 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
21 positive regulation of osteoclast differentiation GO:0045672 9.43 IFNG IL17A TNF
22 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
23 immune response GO:0006955 9.32 CCL17 CD40LG HLA-B HLA-DRB1 IFNG IL10

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL17 CD40LG IFNG IL10 IL17A IL5

Sources for Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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