MCID: ECH003
MIFTS: 63

Echinococcosis malady

Infectious diseases, Liver diseases categories

Summaries for Echinococcosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards: Echinococcosis, also known as hydatidosis, is related to hepatitis and thyroiditis. An important gene associated with Echinococcosis is MT-CO1 (mitochondrially encoded cytochrome c oxidase I), and among its related pathways are Primary immunodeficiency and COPII (Coat Protein 2) Mediated Vesicle Transport. The drug albendazole and the compounds solium and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are hematopoietic system and cellular.

CDC:3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia:63 Echinococcosis, also called hydatid disease, hydatidosis, or echinococcal disease, is a parasitic... more...

Aliases & Classifications for Echinococcosis

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 42NIH Rare Diseases, 48Orphanet, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hydatidosis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

echinococcosis 8 10 60
hydatidosis 8 42 48
echinococcosis, unspecified, of liver 8
liver echinococcus unspecified 8
echinococcosis, pulmonary 60
pulmonary echinococcosis 8
echinococcosis of liver 8
echinococcosis, hepatic 60
hepatic echinococcosis 8
echinococcal disease 8
hydatid disease 8
hydatids 44


External Ids:

Disease Ontology8 DOID:1496
MeSH34 D004443
NCIt39 C84682
ICD9CM27 122
MESH via Orphanet35 D004443
SNOMED-CT via Orphanet57 74942003
UMLS via Orphanet61 C0013502
ICD10 via Orphanet26 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
ICD1025 B67, B67.8

Related Diseases for Echinococcosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Echinococcosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.2HLA-B
2thyroiditis29.8HLA-DRB1
3pancreatitis29.8IL10
4arthritis29.8TAP2, IL10, HLA-DRB1, HLA-B
5tuberculosis29.8HLA-DQB1, IL10, HLA-DRB1, KLRK1, IL12B
6hepatocellular carcinoma29.8TAP2, TAP1, PRDX4, HLA-DRB1, KLRK1
7breast cancer29.8HLA-B, TSPAN32, PRDX4, TAP1, TAP2
8rheumatoid arthritis29.8TSPAN32, IL12B, IL10, HLA-DRB1, HLA-DRB5, HLA-DQB1
9colon cancer29.7TSPAN32, MT-CO1, TAP1
10cystic echinococcosis11.2
11alveolar echinococcosis11.2
12polycystic echinococcosis10.5
13cysticercosis10.5
14hepatitis a10.4
15cerebritis10.4
16taeniasis10.4
17liver disease10.3
18peritonitis10.3
19choledochal cyst10.2
20pulmonary embolism10.2
21cardiac tamponade10.1
22acute pancreatitis10.1
23horner's syndrome10.1
24aspergillosis10.1
25liver sarcoma10.1
26sarcoma10.1
27obstructive jaundice10.1
28acute cholangitis10.1
29cholangitis10.1
30pericarditis10.1
31ovarian cyst10.0
32bronchiectasis10.0TAP2
33pemphigus vulgaris10.0HLA-DRB1
34measles10.0IL12B
35leishmaniasis10.0IL10
36pemphigus foliaceus10.0HLA-DRB1
37vaccinia10.0HLA-B
38vogt-koyanagi-harada disease10.0HLA-DRB1
39galactosemia10.0IL10
40viral hepatitis10.0HLA-DRB1
41dermatomyositis10.0HLA-B
42leprosy10.0HLA-DRB1
43deficiency anemia10.0HLA-B
44sjogren's syndrome10.0TAP2, TAP1
45ovarian cancer10.0TAP2
46celiac disease10.0HLA-DQB1, KLRK1
47common variable immune deficiency10.0IL10
48aphthous stomatitis10.0HLA-B
49polymyositis10.0HLA-B
50paracoccidioidomycosis10.0IL10

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to echinococcosis

Clinical Features for Echinococcosis

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Drugs & Therapeutics for Echinococcosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Echinococcosis

Drug clinical trials:

Search ClinicalTrials for Echinococcosis

Search NIH Clinical Center for Echinococcosis

Search CenterWatch for Echinococcosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Echinococcosis

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Anatomical Context for Echinococcosis

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32MalaCards
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MalaCards organs/tissues related to Echinococcosis:

32
Liver, Brain, Lung, Heart, Spleen, Kidney, Testes, Bone, Skin, Pancreas, Breast, T cells, Spinal cord, Adrenal gland, Colon, Prostate, Testis, Thyroid, Skeletal muscle, Tongue, Temporal lobe

Animal Models for Echinococcosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Echinococcosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.7HLA-DQB1, HLA-B, CD8A, IL10, IL12B, TAP1
2MP:00053849.4TSPAN32, KLRK1, HLA-DQB1, HLA-B, MT-CO1, PRDX4
3MP:00053879.3MT-CO1, HLA-B, HLA-DQB1, KLRK1, CD8A, IL10

Publications for Echinococcosis

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50PubMed
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Articles related to Echinococcosis:

(show top 50)    (show all 924)
idTitleAuthorsYear
1
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
2
PRIMARY CEREBRAL ALVEOLAR ECHINOCOCCOSIS: MYCOLOGY TO THE RESCUE. (24335950)
2013
3
Diagnostics and epidemiology of alveolar echinococcosis in slaughtered pigs from large-scale husbandries in Germany. (23093207)
2013
4
Complicated liver echinococcosis: 30 years of experience from an endemic area. (23963031)
2013
5
Populations at risk for alveolar echinococcosis, France. (23647623)
2013
6
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
7
Mapping the increasing risk of human alveolar echinococcosis in Limburg, The Netherlands. (21733269)
2012
8
Cardiac echinococcosis: surviving 40 years later? (21640604)
2012
9
Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. (22449514)
2012
10
Cystic echinococcosis in a fox-hound hunt worker, UK. (23182144)
2012
11
Isolated invasive endomyocardial cystic echinococcosis presenting with heart failure. (22829839)
2012
12
Recurrent hepatic alveolar echinococcosis: report of the first case in Korea with unproven infection route. (22355210)
2011
13
Cystic echinococcosis in Spain: current situation and relevance for other endemic areas in Europe. (21283615)
2011
14
Comparative analysis of the diagnostic performance of crude sheep hydatid cyst fluid, purified antigen B and its subunit (12 Kda), assessed by ELISA, in the diagnosis of human cystic echinococcosis. (20922427)
2011
15
A historical view of alveolar echinococcosis, 160 years after the discovery of the first case in humans: part 1. What have we learnt on the distribution of the disease and on its parasitic agent? (22040507)
2011
16
An abattoir-based study on the prevalence and economic losses due to cystic echinococcosis in slaughtered herbivores in Ahwaz, south-western Iran. (20398435)
2011
17
Genotype identification of human cystic echinococcosis in Isfahan, central Iran. (20549235)
2010
18
Echinococcosis with particular reference to Southeast Asia. (20624535)
2010
19
Spleen cystic echinococcosis: clinical manifestations and treatment. (20095883)
2010
20
Recurrence of femoral echinococcosis 5 years after a primary surgical procedure. (20170866)
2010
21
Personalized management of patients with inoperable alveolar echinococcosis undergoing treatment with albendazole: usefulness of positron-emission-tomography combined with serological and computed tomography follow-up. (19912267)
2010
22
Diagnosis of alveolar echinococcosis using immunoblotting with plural low molecular weight antigens. (19025727)
2009
23
Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. (19208302)
2009
24
Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis. (17954696)
2008
25
Metabolic viability assessment of cystic echinococcosis using high-field 1H MRS of cyst contents. (18384178)
2008
26
Management of hydatid disease (echinococcosis) in pregnancy. (18199385)
2008
27
Species identification of human echinococcosis using histopathology and genotyping in northwestern China. (18396303)
2008
28
Echinococcosis and Tibetan communities. (18826849)
2008
29
Albendazole for the treatment of human echinococcosis: a review of comparative clinical trials. (17873530)
2007
30
Alveolar echinococcosis, Lithuania. (18258025)
2007
31
Veterinary public health activities at FAO: cysticercosis and echinococcosis. (16343986)
2006
32
Alveolar echinococcosis of the liver in a Tokyo resident with an unknown route of infection: report of a case. (16865524)
2006
33
Molecular confirmation of a case of multiorgan cystic echinococcosis. (16629342)
2006
34
Epidemiological study of the cystic echinococcosis in Morocco. (16473466)
2006
35
Human cystic echinococcosis in Sardinia during the 20th century. (16044696)
2004
36
Cystic echinococcosis in the Berber of the Mid Atlas mountains, Morocco: new insights into the natural history of the disease in humans. (15257798)
2004
37
Ultrasonographic diagnosis and medical treatment of human cystic echinococcosis in asymptomatic school age carriers: 5 years of follow-up. (15158684)
2004
38
Identification of the immunodominant regions of the Em18 antigen and improved serodiagnostic specificity for alveolar echinococcosis. (15752115)
2004
39
Intracerebral alveolar echinococcosis. (12590338)
2003
40
Cystic echinococcosis in a rural Peruvian family. (12080984)
2002
41
Photo quiz. Diagnosis: hydatid bone disease (cystic echinococcosis). (11203184)
2000
42
An epidemiologic survey of human alveolar echinococcosis in southwestern Germany. RAPmerstein Study Group. (10548290)
1999
43
Cystic and alveolar echinococcosis in Turkey. (9924542)
1998
44
Alveolar echinococcosis: Em2plus-ELISA and Em18-western blots for follow-up after treatment with albendazole. (9373660)
1997
45
Intraperitoneal dissemination probably caused by needle biopsy of alveolar echinococcosis of the liver: experimental study. (9327678)
1997
46
Effects of cyclosporin A on the course of murine alveolar echinococcosis and on specific cellular and humoral immune responses against Echinococcus multilocularis. (1563918)
1992
47
The efficacy of chemotherapy with mebendazole in human cystic echinococcosis: long-term follow-up of 52 patients. (1449273)
1992
48
Prevalence of human alveolar echinococcosis in Hokkaido as evaluated by western blotting. (2255119)
1990
49
Cystic echinococcosis in the Xinjiang/Uygur Autonomous Region, People's Republic of China. I. Demographic and epidemiologic data. (2382094)
1990
50
Taeniasis, cysticercosis and echinococcosis/hydatidosis in Nigeria: I--prevalence of human taeniasis, cysticercosis and hydatidosis based on a retrospective analysis of hospital records. (7229322)
1980

Genetic Variations for Echinococcosis

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Expression for genes affiliated with Echinococcosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Echinococcosis

Search GEO for disease gene expression data for Echinococcosis.

Pathways for genes affiliated with Echinococcosis

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Echinococcosis according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TAP1, CD8A
2
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10.3HLA-B, TAP2, TAP1
3
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10.2HLA-DQB1, HLA-DRB5, HLA-DRB1
410.2HLA-DRB1, HLA-DRB5, HLA-DQB1
510.2HLA-DRB1, HLA-DRB5, HLA-DQB1
6
Immune response ICOS pathway in T-helper cell
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10.2HLA-DRB1, HLA-DRB5, HLA-DQB1
710.2HLA-DRB1, HLA-DRB5, HLA-DQB1
8
Immune response NFAT in immune response
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10.2HLA-DRB1, HLA-DRB5, HLA-DQB1
9
Immune response Antigen presentation by MHC class II
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10.2HLA-DQB1, HLA-DRB1, HLA-DRB5
10
Hide members
10.2HLA-DRB1, HLA-DQB1, HLA-DRB5
1110.2IL12B, IL10, HLA-DRB1
12
Hide members
10.2IL12B, HLA-DRB1, CD8A
1310.2HLA-DRB5, HLA-DRB1, CD8A
1410.2TAP1, CD8A, HLA-B, TAP2
1510.2IL10, TAP1, TAP2, CD8A
16
Hide members
10.1HLA-DRB5, HLA-B, HLA-DQB1, HLA-DRB1
1710.1HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
18
Hide members
10.1HLA-B, HLA-DRB1, HLA-DRB5, HLA-DQB1
1910.1HLA-DRB5, HLA-DRB1, IL10, HLA-DQB1
20
Hide members
10.1IL10, HLA-DQB1, HLA-DRB5, HLA-DRB1
21
Hide members
10.1CD8A, HLA-DQB1, HLA-DRB5, HLA-DRB1
22
Hide members
10.1HLA-DRB1, HLA-DQB1, CD8A, HLA-DRB5
2310.1HLA-DQB1, HLA-DRB5, HLA-DRB1, IL12B
2410.1HLA-DQB1, HLA-DRB1, HLA-DRB5, HLA-B, IL10
2510.1HLA-DRB5, HLA-DQB1, HLA-B, CD8A, HLA-DRB1
26
Hide members
10.0IL10, HLA-DRB1, HLA-DRB5, HLA-DQB1, IL12B
2710.0HLA-DRB1, IL10, HLA-DRB5, HLA-DQB1, IL12B
2810.0HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1, TAP1, TAP2
29
Hide members
9.9HLA-B, HLA-DQB1, IL10, CD8A, HLA-DRB1, IL12B
30
Hide members
9.8TAP1, HLA-B, HLA-DRB5, HLA-DRB1, HLA-DQB1, CD8A
31
Hide members
9.8IL12B, HLA-DQB1, HLA-DRB5, HLA-B, HLA-DRB1, TAP1

Compounds for genes affiliated with Echinococcosis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR
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Compounds related to Echinococcosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1solium4410.4HLA-B, MT-ATP6, MT-CO1
2glatiramer acetate44 1111.3IL10, HLA-DRB1
3polyinosinic-polycytidylic acid4410.2KLRK1, HLA-B, IL10, IL12B
4lipoteichoic acid4410.1IL10, HLA-B, IL12B
5atp44 2810.9TAP2, MT-ATP6, TAP1, PRDX4, MT-CO1, HLA-B
6il 10449.9IL12B, CD8A, IL10

GO Terms for genes affiliated with Echinococcosis

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16Gene Ontology
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Cellular components related to Echinococcosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.4HLA-DRB1, HLA-DRB5, HLA-DQB1
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.4HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:03066910.4HLA-DRB5, HLA-DRB1, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:01250710.3HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
5TAP complexGO:04282510.3TAP1, TAP2
6transport vesicle membraneGO:03065810.3HLA-DQB1, HLA-DRB5, HLA-DRB1
7trans-Golgi network membraneGO:03258810.3HLA-DRB5, HLA-DRB1, HLA-DQB1
8endocytic vesicle membraneGO:03066610.1HLA-DQB1, HLA-DRB5, HLA-DRB1
9lysosomal membraneGO:00576510.1HLA-DQB1, HLA-DRB5, HLA-DRB1, RRAGB
10membraneGO:0160209.6PTDSS1, SLC4A3, IL12B, HLA-DRB1, HLA-B, HLA-DQB1

Biological processes related to Echinococcosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.7TAP1, TAP2
2intracellular transport of viral proteins in host cellGO:01906010.6TAP2, TAP1
3peptide transportGO:01583310.6TAP1, TAP2
4negative regulation of myeloid dendritic cell activationGO:03088610.6IL10, TSPAN32
5regulation of interleukin-10 secretionGO:200117910.6HLA-DRB5, HLA-DRB1
6immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.6HLA-DRB1, HLA-DRB5, HLA-DQB1
7antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.6TAP2, TAP1
8regulation of interleukin-4 productionGO:03267310.6HLA-DRB5, HLA-DRB1
9humoral immune response mediated by circulating immunoglobulinGO:00245510.6HLA-DQB1, HLA-DRB5, HLA-DRB1
10detection of bacteriumGO:01604510.6HLA-B, HLA-DRB5, HLA-DRB1
11negative regulation of interferon-gamma productionGO:03268910.6IL10, HLA-DRB1, HLA-DRB5
12T-helper 1 type immune responseGO:04208810.6IL12B, HLA-DRB1, HLA-DRB5
13negative regulation of T cell proliferationGO:04213010.5IL10, HLA-DRB1, HLA-DRB5
14positive regulation of T cell mediated cytotoxicityGO:00191610.5TAP2, TAP1, IL12B, HLA-B
15interferon-gamma-mediated signaling pathwayGO:06033310.5HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.5TAP2, TAP1, HLA-B
17T cell costimulationGO:03129510.4HLA-DRB1, HLA-DRB5, HLA-DQB1
18antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4HLA-B, TAP1, TAP2
19cytokine-mediated signaling pathwayGO:01922110.4HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB1
20T cell receptor signaling pathwayGO:05085210.4HLA-DRB1, HLA-DRB5, HLA-DQB1
21immune responseGO:00695510.4CD8A, HLA-DRB1, HLA-DRB5, HLA-B, HLA-DQB1
22antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.3HLA-DRB1, HLA-DRB5, HLA-DQB1
23antigen processing and presentation of peptide antigen via MHC class IGO:00247410.3HLA-B, TAP1, TAP2
24inflammatory response to antigenic stimulusGO:00243710.3HLA-DRB1, HLA-DRB5
25defense response to protozoanGO:04283210.3TSPAN32, IL12B
26positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:03577410.2HLA-DRB1, HLA-DRB5
27negative regulation of growth of symbiont in hostGO:04413010.0IL12B, IL10

Molecular functions related to Echinococcosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.5TAP1, TAP2
2peptide transporter activityGO:01519710.4TAP1, TAP2
3MHC class I protein bindingGO:04228810.4CD8A, TAP1, TAP2
4TAP2 bindingGO:04697910.3TAP1, TAP2
5MHC class II receptor activityGO:03239510.3HLA-DRB1, HLA-DQB1
6peptide antigen bindingGO:04260510.3TAP2, TAP1, HLA-DRB1, HLA-DRB5, HLA-B
7TAP1 bindingGO:04697810.2TAP1, TAP2
8oligopeptide-transporting ATPase activityGO:01542110.0TAP1, TAP2

Products for genes affiliated with Echinococcosis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Echinococcosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet