MCID: ECH003
MIFTS: 52

Echinococcosis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Echinococcosis

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Aliases & Descriptions for Echinococcosis:

Name: Echinococcosis 10 12 36 2 65
Hydatidosis 10 45
Echinococcosis, Unspecified, of Liver 10
Liver Echinococcus Unspecified 10
Echinococcosis, Pulmonary 65
Pulmonary Echinococcosis 10
 
Echinococcosis, Hepatic 65
Echinococcosis of Liver 10
Hepatic Echinococcosis 10
Echinococcal Disease 10
Hydatid Disease 10
Hydatids 47

Classifications:



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Disease Ontology10 DOID:1496
ICD1027 B67, B67.90, B67.8
ICD9CM29 122
MeSH36 D004443
NCIt42 C84682
UMLS65 C0013502, C0013504, C0013505

Summaries for Echinococcosis

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Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary: Echinococcosis, also known as hydatidosis, is related to sparganosis and rheumatoid arthritis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways are Cell adhesion molecules (CAMs) and Pertussis. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain.

CDC:2 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia:68 Echinococcosis, also called hydatid disease, hydatidosis, or echinococcal disease, is a parasitic... more...

Related Diseases for Echinococcosis

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Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1sparganosis30.0MT-CO1, MT-ND1
2rheumatoid arthritis27.9HLA-B, HLA-DRB1, IL10, IL17A, IL6, TLR2
3malaria27.4CD8A, HLA-B, HLA-DRB1, IL10, IL17A, IL6
4alveolar echinococcosis12.5
5cystic echinococcosis12.5
6polycystic echinococcosis12.2
7cardiac hydatid cysts with intracavitary expansion11.9
8postinfectious encephalomyelitis10.8HLA-B, HLA-DRB1
9idiopathic juxtafoveal retinal telangiectasia10.8HLA-B, HLA-DRB1
10psoriasis10.7HLA-B, HLA-DRB1
11intermediate uveitis10.7HLA-B, HLA-DRB1
12maculopapular lupus rash10.7HLA-DRB1, IL10
13congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome10.7HLA-DRB1, TNF
14hepatitis10.7
15dioctophymiasis10.7IL10, MT-CO1
16punctate palmoplantar keratoderma type 210.6IL10, TNF
17autoimmune polyglandular syndrome type 210.6HLA-DRB1, TNF
18best1 retinopathy10.6HLA-DRB1, TNF
19pityriasis rosea10.6CD8A, HLA-DRB1
20primary progressive freezing gait10.6IL10, TNF
21non-distal monosomy 10q10.6HLA-DRB1, TNF
22bronchiolitis10.6HLA-B, IL6
23androgen insensitivity syndrome, mild10.6HLA-DRB1, TNF
24kearns-sayre syndrome10.6IL10, TNF
25finnish upper limb-onset distal myopathy10.6HLA-DRB1, IL17A
26acneiform dermatitis10.6HLA-B, TNF
27ureterocele10.6CD8A, TNF
28metanephric adenoma10.6HLA-B, HLA-DRB1
29multifocal lymphangioendotheliomatosis with thrombocytopenia10.6IL10, TNF
30alternating exotropia10.6IL10, TNF
31rhizomelic dysplasia patterson lowry type10.6HLA-DRB1, TNF
32glomangiomatosis10.5IL10, IL6
33catamenial pneumothorax10.5IL10, IL6
34multicentric osteolysis nephropathy10.5IL10, IL6
35late congenital syphilis10.5CD8A, IL17A
36louping ill10.5CD8A, IL10
37syphilitic encephalitis10.5CES1, MT-CO1
38opisthorchiasis10.5IL10, TNF
39human herpesvirus 810.5HLA-B, IL6
40neonatal period electroclinical syndrome10.5IL10, IL6
41microsomia hemifacial radial defects10.5HLA-B, HLA-DRB1, TNF
42nut allergy10.5HLA-DRB1, IL10
43reticulosarcoma10.5CD8A, HLA-B, IL10
44stomach cancer10.5CD8A, IL6
45cryptosporidiosis10.5HLA-B, HLA-DRB1, TNF
46plantar nerve lesion10.5IL6, TNF
47intermediate dend syndrome10.5IL6, TNF
48crohn's disease10.4IL6, TNF
49blue color blindness10.4HLA-B, HLA-DRB1, TNF
50artery disease10.4HLA-B, HLA-DRB1, TNF

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to echinococcosis

Symptoms for Echinococcosis

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Drugs & Therapeutics for Echinococcosis

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Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1BenzimidazoleexperimentalPhase 4451-17-25798
2Antiparasitic AgentsPhase 41854
3AnthelminticsPhase 4379
4Anti-Infective AgentsPhase 417220
5Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With BenzimidazolesRecruitingNCT00658294Phase 4
2Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
3Long-term Results of Comprehensive AE ManagementCompletedNCT02509884
4Epi Cystic Hydatid Disease PeruCompletedNCT00138346
5The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the LiverCompletedNCT01785212
6Parasitic Infections of the Gastrointestinal TractRecruitingNCT00001162

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: echinococcosis

Genetic Tests for Echinococcosis

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Anatomical Context for Echinococcosis

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MalaCards organs/tissues related to Echinococcosis:

33
Liver, Lung, Brain, Heart, Kidney, Spleen, Breast

Animal Models for Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Echinococcosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Echinococcosis

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Articles related to Echinococcosis:

(show top 50)    (show all 1086)
idTitleAuthorsYear
1
Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial. (26825878)
2016
2
Neotropical echinococcosis caused by Echinococcus vogeli in a 6-year-old child: the second case report in humans in French Guiana. (27077626)
2016
3
Synchronous adenocarcinoma and echinococcosis in the same ovary: a rare clinical entity. (26435657)
2015
4
Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. (26409727)
2015
5
The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis. (26509179)
2015
6
Surveillance of Human Echinococcosis in Castilla-Leon (Spain) between 2000-2012. (26484764)
2015
7
Human Alveolar Echinococcosis, Czech Republic, 2007-2014. (26583699)
2015
8
Development of a cutaneous fistula following hepatic cystic echinococcosis. (26413444)
2015
9
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
10
Laparoscopic approach for total cystectomy in treating hepatic cystic echinococcosis. (25489977)
2014
11
MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep. (24782918)
2014
12
The Production and Comparative Evaluation of Native and Recombinant Antigens for the Fast Serodiagnosis of Cystic Echinococcosis with Dot Immunogold Filtration Assay. (25313824)
2014
13
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
14
A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. (23084536)
2013
15
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
16
Molecular diagnosis of polycystic echinococcosis due to Echinococcus vogeli in a Paraguayan immigrant in Argentina. (23824768)
2013
17
Isolated primary renal echinococcosis: a rare entity. (23435774)
2013
18
High resolution melting technique for molecular epidemiological studies of cystic echinococcosis: differentiating G1, G3, and G6 genotypes of Echinococcus granulosus sensu lato. (23832641)
2013
19
Ovarian hydatid cyst in pediatric patient commencing as ovarian tumor: a rare site of echinococcosis. (23272291)
2012
20
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
21
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
22
Development and evaluation of flow through technique for diagnosis of cystic echinococcosis in sheep. (21507576)
2011
23
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
24
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
25
A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom. (21896804)
2011
26
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
27
Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. (21715578)
2011
28
Human echinococcosis: a neglected disease. (20862339)
2010
29
Echinococcosis/hydatidosis: a severe threat in Mediterranean countries. (20888694)
2010
30
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
31
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
32
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
33
Echinococcosis: a review. (18938096)
2009
34
Complications of extrahepatic echinococcosis: fistulization of an adrenal hydatid cyst into the intestine. (18322969)
2008
35
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
36
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
37
Research on targeting sources of alveolar echinococcosis in Japan. (17662388)
2007
38
Stereological evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method. (17105589)
2006
39
Usefulness of severe combined immunodeficiency (scid) and inbred mice for studies of cysticercosis and echinococcosis. (16338168)
2006
40
Comparative evaluation of western blotting in hepatic and pulmonary cystic echinococcosis. (17285854)
2006
41
Brief historical remarks as an introduction for the international symposium on taeniasis/cysticercosis and echinococcosis. (16337830)
2006
42
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
43
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
44
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
45
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. (10980173)
2000
46
Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. (9875648)
1998
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
49
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989
50

Variations for Echinococcosis

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Expression for genes affiliated with Echinococcosis

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Search GEO for disease gene expression data for Echinococcosis.

Pathways for genes affiliated with Echinococcosis

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Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.6CD8A, HLA-B, HLA-DRB1
29.3IL10, IL6, TNF
39.3IL10, IL6, TNF
49.3IL10, IL6, TNF
5
Show member pathways
9.1IL17A, IL6, TLR2
6
Show member pathways
9.1IL17A, IL6, TLR2
79.1IL6, TLR2, TNF
89.1CD8A, IL10, IL17A, TNF
99.1HLA-B, HLA-DRB1, IL6, TNF
109.0HLA-DRB1, IL10, IL6, TNF
11
Show member pathways
9.0IL6, MT-ATP6, MT-CO1, TNF
129.0CD8A, IL10, IL6, TNF
139.0CD8A, IL10, IL6, TNF
149.0CD8A, HLA-DRB1, IL6, TNF
15
Show member pathways
9.0HLA-DRB1, IL10, TLR2, TNF
16
Show member pathways
9.0IL10, IL17A, IL6, TNF
178.8IL10, IL6, TLR2, TNF
188.8IL10, IL6, TLR2, TNF
198.8IL10, IL6, TLR2, TNF
20
Show member pathways
8.7HLA-B, IL10, IL17A, IL6, TNF
21
Show member pathways
8.6CD8A, IL10, IL17A, IL6, TNF
22
Show member pathways
8.5HLA-B, HLA-DRB1, IL6, TLR2, TNF
238.5HLA-DRB1, IL10, IL6, TLR2, TNF
24
Show member pathways
8.4IL10, IL17A, IL6, TLR2, TNF
258.4HLA-DRB1, IL17A, IL6, TLR2, TNF
26
Show member pathways
7.5CD8A, HLA-B, HLA-DRB1, IL10, IL17A, IL6

GO Terms for genes affiliated with Echinococcosis

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Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:003280010.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
3antigen processing and presentationGO:001988210.3HLA-B, HLA-DRB1
4defense response to protozoanGO:004283210.3IL10, IL6
5negative regulation of growth of symbiont in hostGO:004413010.2IL10, TNF
6epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.2IL6, TNF
7negative regulation of interleukin-6 productionGO:003271510.2IL10, TNF
8positive regulation of chemokine productionGO:003272210.1TLR2, TNF
9negative regulation of lipid storageGO:001088810.0IL6, TNF
10cellular response to hepatocyte growth factor stimulusGO:003572910.0IL10, IL6
11positive regulation of osteoclast differentiationGO:004567210.0IL17A, TNF
12response to glucocorticoidGO:00513849.7IL10, IL6, TNF
13T cell activationGO:00421109.7CD8A, IL6
14positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL10, IL6, TNF
15agingGO:00075689.6IL10, IL6, MT-CO1
16defense response to Gram-positive bacteriumGO:00508309.5IL6, TLR2, TNF
17immune responseGO:00069557.8HLA-DRB1, IL10, IL17A, IL6, TLR2, TNF

Sources for Echinococcosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet