MCID: ECL001
MIFTS: 63

Eclampsia malady

Summaries for Eclampsia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Eclampsia (Greek for \"shining forth\") is an acute and life-threatening complication of pregnancy... more...

MalaCards: Eclampsia, also known as eclampsia in puerperium, is related to pre-eclampsia and severe pre-eclampsia. An important gene associated with Eclampsia is STOX1 (storkhead box 1), and among its related pathways are HIF-1-alpha transcription factor network and Complement and coagulation cascades. The drugs nitroglycerin and magnesium sulfate and the compounds creatinine and vegf have been mentioned in the context of this disorder. Affiliated tissues include endothelial, placenta and testes, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Eclampsia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

eclampsia 8 42 10 44 60
eclampsia in puerperium 8 60
eclampsia unspecified 8
eclampsia, postpartum 8
postpartum eclampsia 8
eclampsia nos 8


External Ids:

Disease Ontology8 DOID:13593
NCIt39 C87167
MeSH34 D004461
ICD1025 O15, O15.2

Related Diseases for Eclampsia

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17GeneCards, 18GeneDecks
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Diseases related to Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.1HLA-G, STOX1, FLT1
2severe pre-eclampsia31.6IGFBP1, MAOA, PGF, LEP, VCAM1, SERPINE1
3hypertension31.1PGF, LEP, VCAM1, SERPINE1, F5
4hellp syndrome31.0SERPINC1, SERPINE1, F5, APOH
5mild pre-eclampsia30.8SOD1, IGFBP1, VCAM1
6gestational diabetes30.5LSL, IGFBP1, PGF, LEP
7proteinuria30.4PGF, FLT1, HLA-G, APOH, LSL
8thrombophilia30.4SERPINC1, SERPINE1, F5, APOH
9placental insufficiency30.4PGF, IGFBP1, FLT1
10placental abruption30.4SERPINC1, F5
11diabetes mellitus30.3LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1
12essential hypertension30.3SOD1, HLA-G, LEP, SERPINE1
13hepatitis30.3IGFBP1
14obesity30.2LSL, FLT1, IGFBP1, MAOA, LEP, SERPINE1
15chorioamnionitis30.2FLT1
16breast cancer30.1HLA-G, FLT1, IGFBP1, PGF, LEP, SERPINE1
17antiphospholipid syndrome30.1SERPINC1, VCAM1, F5, APOH
18pancreatitis30.1SOD1
19thrombocytopenia29.9APOH, F5, SERPINC1
20myocardial infarction29.7LSL, F5, IGFBP1, PGF, SERPINE1, SERPINC1
21diabetic retinopathy29.7SOD1, FLT1, IGFBP1, PGF, VCAM1, SERPINE1
22vascular disease29.7SOD1, APOH, F5, VCAM1, SERPINE1, SERPINC1
23hyperglycemia29.7LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1
24polycystic ovary syndrome29.7SERPINE1, LEP, IGFBP1, LSL
25ischemia29.7SOD1, FLT1, PGF
26hypogonadism29.7LSL, TAC3, LEP
27retinal vein occlusion29.7APOH, F5, SERPINC1
28antithrombin iii deficiency29.7APOH, F5, SERPINC1
29migraine29.7MAOA, APOH
30vasculitis29.7VCAM1, APOH
31central retinal vein occlusion29.7F5, APOH
32portal vein thrombosis29.7F5, SERPINC1
33hypothyroidism29.7LEP, LSL
34down syndrome29.7PGF, SOD1
35purpura29.7SERPINC1
36lipodystrophy29.7LSL, LEP
37glomerulonephritis29.7VCAM1
38acute pancreatitis29.7SOD1
39cortical blindness10.4
40cerebritis10.4
41retinitis10.3
42hypertensive encephalopathy10.2
43retinal detachment10.2
44periodontitis10.2
45peripartum cardiomyopathy10.1
46intrahepatic cholestasis10.1
47hypertensive retinopathy10.1
48cerebral palsy10.1
49cholestasis10.1
50hemolytic anemia10.1

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to eclampsia

Clinical Features for Eclampsia

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Drugs & Therapeutics for Eclampsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Eclampsia

Drug clinical trials:

Search ClinicalTrials for Eclampsia

Search NIH Clinical Center for Eclampsia

Search CenterWatch for Eclampsia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Eclampsia

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Anatomical Context for Eclampsia

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32MalaCards
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MalaCards organs/tissues related to Eclampsia:

32
Endothelial, Placenta, Testes, Liver, Nk cells, Breast, Kidney, T cells, Brain, Thyroid, Myeloid, Pancreas, Heart, Pituitary, B cells, Temporal lobe, Occipital lobe, Fetal lung, Monocytes, Ovary, Skin, Lung, Colon, Retina, Whole blood, Eye

Animal Models for Eclampsia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.7CORIN, SOD1, APOH, HLA-G, FLT1, F5
2MP:000538511.3VCAM1, CORIN, SOD1, FLT1, MAOA, PGF
3MP:000538711.2SOD1, HLA-G, FLT1, IGFBP1, PGF, LEP
4MP:000537011.1F5, IGFBP1, LEP, SERPINE1, SERPINC1, SOD1

Publications for Eclampsia

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50PubMed
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Articles related to Eclampsia:

(show top 50)    (show all 1409)
idTitleAuthorsYear
1
Maternal and perinatal outcomes among women with eclampsia admitted to a tertiary care hospital in Hyderabad, Pakistan. (24135290)
2013
2
Clinical morbidities, trends, and demographics of eclampsia: a population-based study. (23727516)
2013
3
Use of magnesium sulfate for treatment of pre-eclampsia and eclampsia in Mexico. (23465851)
2013
4
Prediction of pre-eclampsia by a combination of maternal history, uterine artery Doppler, and mean arterial pressure (a prospective study of 200 cases). (24431597)
2013
5
A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia. (23897580)
2013
6
2D-ultrasound and endocrinologic evaluation of placentation in early pregnancy and its relationship to fetal birthweight in normal pregnancies and pre-eclampsia. (23756051)
2013
7
Group B streptococcal colonization and the risk of pre-eclampsia. (22813482)
2013
8
Haptoglobin phenotype, pre-eclampsia, and response to supplementation with vitamins C and E in pregnant women with type-1 diabetes. (23718253)
2013
9
Successful pregnancy outcome in a case of pheochromocytoma presenting as severe pre-eclampsia with normal urinary catecholamine level. (23869326)
2013
10
Anterior dislocation of shoulder in eclampsia: a case report. (22863346)
2012
11
Ethnicity, body mass index and risk of pre-eclampsia in a multiethnic New Zealand population. (23020751)
2012
12
Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus. (22387044)
2012
13
Benefits of using magnesium sulphate (MgSOa88) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria. (22873658)
2012
14
Metastin levels in pregnancies complicated by pre-eclampsia and their relation with disease severity. (22769053)
2012
15
Association of hypertriglyceridaemia with pre-eclampsia, preterm birth, gestational diabetes and uterine artery pulsatility index. (23448624)
2012
16
LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study. (22713493)
2012
17
Seasonal trend in the occurrence of preeclampsia and eclampsia in Texas. (21976279)
2012
18
Haemodynamics in women with untreated pre-eclampsia. (22731876)
2012
19
The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia. (22555639)
2012
20
Is there a role for isofurans and neuroprostanes in pre-eclampsia and normal pregnancy? (21827297)
2012
21
Glucose-6-phosphate Dehydrogenase Deficiency and Pre-eclampsia: Possibility of Treatment. (23115422)
2011
22
Delayed postpartum preeclampsia and eclampsia: demographics, clinical course, and complications. (21979459)
2011
23
Levels of soluble endothelial selectin in umbilical cord serum are influenced by gestational age and histological chorioamnionitis, but not by pre-eclampsia. (21827570)
2011
24
Screening for pre-eclampsia--lessons from aneuploidy screening. (21257082)
2011
25
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
26
Contribution of interferon-gamma receptor 1 gene polymorphisms to pre-eclampsia in China. (20070287)
2010
27
Study of follicle-stimulating hormone receptor and tyrosine hydroxylase polymorphisms and pre-eclampsia in Chinese Han population]. (20646572)
2010
28
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. (19811463)
2009
29
Population-based estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia. (18611258)
2008
30
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
31
Circulating endothelial progenitor cells during normal pregnancy and pre-eclampsia. (16836609)
2006
32
Efficacy of AT in pre-eclampsia: a case-control prospective trial. (14961155)
2004
33
Serum granulysin is a marker for Th1 type immunity in pre-eclampsia. (15030522)
2004
34
Reduced function of endothelial prostacyclin in human omental resistance arteries in pre-eclampsia. (12433966)
2002
35
The effect of factor V Leiden, oral contraceptive use, type of oral contraceptives and pregnancy on APC-r levels in women with or without a history of pre-eclampsia. (11301177)
2001
36
C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia/eclampsia among Australian women. (11096266)
2001
37
The influence of maternal age on pregnancy outcome in patients with early onset, severe pre-eclampsia. (12521852)
2001
38
Essential fatty acids profile and lipid peroxides in severe pre-eclampsia. (10370762)
1999
39
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. (10492869)
1999
40
Distortion of maternal-fetal angiotensin II type 1 receptor allele transmission in pre-eclampsia. (9719367)
1998
41
Doppler ultrasound of the uterine arteries: the importance of bilateral notching in the prediction of pre-eclampsia, placental abruption or delivery of a small-for-gestational-age baby. (8705410)
1996
42
Systemic and fetal-maternal nitric oxide synthesis in normal pregnancy and pre-eclampsia. (8813307)
1996
43
The effect of pre-eclampsia on human placental corticotrophin-releasing hormone content and processing. (7567800)
1995
44
Case-control study of maternal blood group and severe pre-eclampsia. (8523376)
1995
45
Relation between birth weight and thyroid function in preeclampsia-eclampsia. (8125405)
1994
46
Increased plasma levels of the novel vasoconstrictor peptide endothelin in severe pre-eclampsia. (1879597)
1991
47
Association between susceptibility to pre-eclampsia within families and HLA DR4. (2572795)
1989
48
Preliminary report on the use of magnesium sulfate in cases of severe pre-eclampsia and eclampsia. (3834084)
1985
49
Human leucocyte antigens and mixed lymphocyte reaction in severe pre-eclampsia. (147119)
1978
50
Serum proteins in normal pregnancy and mild pre-eclampsia. (4104344)
1971

Genetic Variations for Eclampsia

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Expression for genes affiliated with Eclampsia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for genes affiliated with Eclampsia

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems
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Compounds for genes affiliated with Eclampsia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1creatinine4412.1LSL, SOD1, APOH, HLA-G, IGFBP1, FLT1
2vegf4412.1VCAM1, PGF, SERPINE1, IGFBP1, F5, HLA-G
3nitric oxide44 11 2414.0SERPINE1, VCAM1, TAC3, PGF, IGFBP1, F5
4lipid4412.0VCAM1, SOD1, LEP, PGF, HLA-G, FLT1
5prostacyclin4411.9LEP, PGF, SERPINC1, FLT1, APOH, SOD1
6cholesterol44 28 11 2414.9LEP, F5, FLT1, HLA-G, APOH, SERPINE1
7fibrinogen4411.8LEP, SERPINE1, VCAM1, SERPINC1, IGFBP1, F5
8progesterone44 59 28 11 2415.8HLA-G, FLT1, F5, IGFBP1, LEP, APOH
9testosterone44 59 11 2414.8LEP, MAOA, SERPINC1, SERPINE1, VCAM1, IGFBP1
10arginine4411.7LEP, SOD1, IGFBP1, F5, APOH, LSL
11lactate4411.6IGFBP1, APOH, SOD1, LSL, F5, VCAM1
12homocysteine44 2412.6SERPINC1, APOH, F5, LSL, SERPINE1, VCAM1
13p0024411.6LSL, APOH, FLT1, F5, IGFBP1, LEP
14phosphatidylinositol4411.5LSL, APOH, FLT1, IGFBP1, PGF, VCAM1
15tibolone4411.5F5, LEP, SERPINE1, SERPINC1, LSL
168-isoprostane4411.5APOH, LEP, VCAM1, SERPINE1, SOD1
17p0034411.5FLT1, HLA-G, APOH, LSL, SERPINE1
18metformin44 49 1113.4IGFBP1, LEP, SERPINE1, F5, LSL
19oxygen44 2412.4FLT1, IGFBP1, PGF, HLA-G, MAOA
20copper44 2412.4SOD1, APOH, F5, IGFBP1, LSL
21heparin44 28 11 2414.4APOH, PGF, FLT1, VCAM1
22methotrexate44 49 1113.3APOH, LSL, LEP, SERPINE1, HLA-G
23rosiglitazone44 49 28 11 2415.3VCAM1, LSL, IGFBP1, LEP
24citalopram49 44 11 2414.3LEP, MAOA, SERPINE1, LSL
25raloxifene44 28 49 1114.3F5, SERPINC1, SERPINE1, LSL
26kininogen4411.2SERPINE1, F5, APOH, SERPINC1
27uric acid44 2412.2APOH, F5, SERPINE1
28glucose4411.2PGF, FLT1, LSL, APOH
29c-peptide4411.2LSL, IGFBP1, LEP, SERPINE1
30malondialdehyde4411.2APOH, LSL, F5, SOD1
31pioglitazone44 49 28 1114.2IGFBP1, LEP, VCAM1, SERPINE1
32tamoxifen44 49 28 1114.2IGFBP1, VCAM1, LSL
33epinephrine44 11 2413.2F5, MAOA, IGFBP1, LSL, LEP
34ancrod4411.2SERPINE1, SERPINC1, F5
35pravastatin44 49 28 11 2415.2SERPINE1, LSL, LEP, VCAM1
36estrogen4411.1TAC3, APOH
37progestin4411.1F5, IGFBP1, SERPINE1, SERPINC1
38beta-hydroxybutyrate4411.1LSL, IGFBP1, LEP
39gnrh4411.1IGFBP1, TAC3
40matrigel4411.1SERPINE1, PGF, HLA-G, FLT1
41ascorbic acid44 2412.1SOD1, MAOA, LEP, SERPINC1, F5
42superoxide44 2412.1VCAM1, TAC3, APOH
43coumarins4411.0APOH, MAOA
44dexamethasone44 49 28 1114.0MAOA
45p0054410.9PGF
46n(g)-nitro-l-arginine methyl ester4410.9SOD1, LEP, SERPINE1
47atorvastatin44 49 28 11 2414.9PGF, VCAM1, SERPINE1, F5
48sodium nitroprusside4410.8SERPINE1, SOD1, LEP, VCAM1
49alpha tocopherol4410.6APOH
50levonorgestrel44 59 28 1113.5F5, IGFBP1, SERPINC1

GO Terms for genes affiliated with Eclampsia

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16Gene Ontology
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Cellular components related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.5SOD1, F5, IGFBP1, PGF, TAC3, LEP
2extracellular spaceGO:00561511.4SERPINC1, SOD1, APOH, FLT1, F5, IGFBP1

Biological processes related to Eclampsia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00756511.1LEP, TAC3, PGF, CORIN
2regulation of blood pressureGO:00821711.0CORIN, SOD1, LEP
3platelet degranulationGO:00257610.9SOD1, F5, SERPINE1
4negative regulation of fibrinolysisGO:05191810.8SERPINE1, APOH
5leukocyte tethering or rollingGO:05090110.7LEP, VCAM1
6negative regulation of blood coagulationGO:03019510.7SERPINE1, APOH
7positive regulation of blood coagulationGO:03019410.6APOH, SERPINE1
8positive regulation of angiogenesisGO:04576610.5FLT1, PGF, SERPINE1

Molecular functions related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.7VCAM1, MAOA

Products for genes affiliated with Eclampsia

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet