MCID: ECL001
MIFTS: 64

Eclampsia malady

Rare diseases, Cardiovascular diseases, Reproductive diseases categories
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Summaries for Eclampsia

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Wikipedia:65 Eclampsia (from the Greek ????????? more...

MalaCards based summary: Eclampsia, also known as eclampsia in puerperium, is related to pre-eclampsia and mild pre-eclampsia. An important gene associated with Eclampsia is STOX1 (storkhead box 1), and among its related pathways are Dopamine metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drugs nitroglycerin and magnesium sulfate and the compounds ancrod and coumarins have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related mouse phenotypes are liver/biliary system and embryogenesis.

Aliases & Classifications for Eclampsia

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Eclampsia, Aliases & Descriptions:

Name: Eclampsia 8 42 10 44 62
Eclampsia in Puerperium 8 62
 
Eclampsia, Postpartum 8
Postpartum Eclampsia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Reproductive diseases


External Ids:

Disease Ontology8 DOID:13593
NCIt39 C87167
MeSH34 D004461
ICD1025 O15, O15.2

Related Diseases for Eclampsia

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Diseases in the Pre-Eclampsia family:

eclampsia Severe Pre-Eclampsia

Diseases related to Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.8STOX1, FLT1, HLA-G
2mild pre-eclampsia31.2IGFBP1, SOD1, VCAM1
3placental insufficiency30.9IGFBP1, PGF, FLT1
4placental abruption30.9SERPINC1, F5
5gestational diabetes30.9IGFBP1, LEP, PGF
6hypertension30.8LEP, SERPINE1, PGF, VCAM1, F5
7hellp syndrome30.6APOH, SERPINE1, SERPINC1, GSTP1, F5
8proteinuria30.6HLA-G, APOH, PGF, FLT1
9purpura30.4SERPINC1
10essential hypertension30.3SOD1, SERPINE1, LEP, HLA-G
11vascular disease30.3APOH, SERPINC1
12thrombophilia30.2APOH, SERPINE1, SERPINC1, F5
13portal vein thrombosis30.2F5, SERPINC1
14central retinal vein occlusion30.2F5, APOH
15choriocarcinoma30.2FLT1, PGF, LEP, HLA-G
16antiphospholipid syndrome30.2APOH, SERPINC1, VCAM1, F5
17pregnancy loss30.2F5, SERPINC1, APOH, HLA-G
18insulin resistance30.1IGFBP1, LEP, SERPINE1, PGF, VCAM1
19thrombocytopenia30.1F5, SERPINC1, APOH
20retinal vein occlusion30.0APOH, SERPINC1, F5
21antithrombin iii deficiency30.0APOH, SERPINC1, F5
22diabetes mellitus30.0IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, VCAM1
23polycystic ovary syndrome29.9SERPINE1, LEP, IGFBP1
24infertility29.9IGFBP1, HLA-G, LEP
25thromboembolism29.8F5, SERPINC1, SERPINE1, APOH
26obesity29.7MAOA, FLT1, SERPINE1, LEP, IGFBP1
27hyperglycemia29.6IGFBP1, LEP, SERPINE1, SOD1, VCAM1
28severe pre-eclampsia29.6MAOA, VCAM1, PGF, SERPINC1, SERPINE1, APOH
29diabetic retinopathy29.5IGFBP1, SERPINE1, SOD1, PGF, FLT1, VCAM1
30myocardial infarction29.5IGFBP1, SERPINE1, SERPINC1, PGF, F5
31breast cancer29.4IGFBP1, HLA-G, LEP, SERPINE1, PGF, FLT1
32endotheliitis10.8
33blindness10.5
34eales disease10.5SOD1
35retinal artery occlusion10.5APOH
36thrombophlebitis10.5APOH
37hypoxia10.4
38branch retinal artery occlusion10.4F5
39retinal vasculitis10.4APOH
40cortical blindness10.4
41cerebritis10.4
42retinitis10.4
43carotid artery thrombosis10.4SERPINE1
44sneddon syndrome10.4APOH, SERPINC1
45proliferative diabetic retinopathy10.3IGFBP1, FLT1, VCAM1
46meningococcemia10.3SERPINC1, F5
47protein-energy malnutrition10.3IGFBP1, LEP
48post-thrombotic syndrome10.3SERPINC1, F5
49legg-calve-perthes disease10.3SERPINC1, F5
50retinal detachment10.3

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to eclampsia

Symptoms for Eclampsia

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Drugs & Therapeutics for Eclampsia

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Drug clinical trials:

Search ClinicalTrials for Eclampsia

Search NIH Clinical Center for Eclampsia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Eclampsia

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Anatomical Context for Eclampsia

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MalaCards organs/tissues related to Eclampsia:

32
Placenta, Endothelial, Testes, Liver, Neutrophil, Breast, Nk cells, Brain, Kidney, Thyroid, T cells, Eye, Heart, Pancreas, Myeloid, Pituitary, Whole blood, Retina, Colon, Lung, Skin, Ovary, Monocytes, B cells, Temporal lobe, Occipital lobe, Fetal lung

Animal Models for Eclampsia or affiliated genes

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MGI Mouse Phenotypes related to Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, F5
2MP:00053808.7F5, VCAM1, FLT1, PGF, SERPINC1, LEP
3MP:00107688.1LEP, APOH, SERPINE1, SERPINC1, SOD1, FLT1
4MP:00053878.1IGFBP1, HLA-G, LEP, SERPINE1, SERPINC1, SOD1
5MP:00107718.0LEP, SERPINE1, PGF, CORIN, GSTP1, F5
6MP:00053787.8LEP, SERPINE1, PGF, FLT1, VCAM1, CORIN
7MP:00053857.6SOD1, SERPINC1, SERPINE1, LEP, PGF, FLT1
8MP:00053767.1F5, HLA-G, LEP, APOH, SERPINE1, SERPINC1

Publications for Eclampsia

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Articles related to Eclampsia:

(show top 50)    (show all 1431)
idTitleAuthorsYear
1
Comparison of serum maternal adiponectin concentrations in women with isolated intrauterine growth retardation and intrauterine growth retardation concomitant with pre-eclampsia. (25317046)
2014
2
A report from #BlueJC: Can measuring angiogenic factors help with predicting preterm pre-eclampsia in low-risk women? (24428457)
2014
3
Eclampsia: trends in incidence and outcomes over 30 years. (23271385)
2013
4
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
5
Maternal and perinatal outcomes among women with eclampsia admitted to a tertiary care hospital in Hyderabad, Pakistan. (24135290)
2013
6
A case-control study of placental lesions associated with pre-eclampsia. (23200099)
2013
7
Aspirin for pre-eclampsia: beware of subgroup meta-analysis. (23610032)
2013
8
Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia. (24303960)
2013
9
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
10
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
11
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. (22540831)
2012
12
Improving diagnosis and clinical management of pre-eclampsia. (22452158)
2012
13
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. (22561779)
2012
14
Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia. (22663329)
2012
15
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
16
An unexpected tail of VEGF and PlGF in pre-eclampsia. (22103490)
2011
17
Fractional excretion of urea in pre-eclampsia: a clinical observation. (22057072)
2011
18
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
19
A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes. (21340620)
2011
20
Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)
2011
21
A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. (21973132)
2011
22
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
23
PP13 as a marker of pre-eclampsia: A two platform comparison study. (21257081)
2011
24
Preeclampsia/eclampsia: an insight into the dilemma of treatment by the anesthesiologist. (22052138)
2011
25
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. (21688303)
2011
26
Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsia]. (20140873)
2010
27
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
28
Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (19108943)
2009
29
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
30
Predictors and risk factors of pre-eclampsia. (18854808)
2008
31
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
32
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. (18226121)
2008
33
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
34
Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)
2007
35
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)
2007
36
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
37
Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study. (16455620)
2006
38
Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor-binding sites detected with comparative promoter analysis. (16403800)
2006
39
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
40
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
41
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. (12653685)
2003
42
Soluble adhesion molecules: marker of pre-eclampsia and intrauterine growth restriction. (12422906)
2002
43
Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. (11554693)
2001
44
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
45
Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. (9038589)
1997
46
Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro--a possible role in the etiology of pre-eclampsia? (8952225)
1996
47
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension. (8730885)
1996
48
Anticardiolipin antibodies in eclampsia. (1348988)
1992
49
Severe pre-eclampsia of early onset. (6196074)
1983
50
The management of severe pre-eclampsia. (1050623)
1976

Variations for Eclampsia

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Expression for genes affiliated with Eclampsia

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Expression patterns in normal tissues for genes affiliated with Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for genes affiliated with Eclampsia

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Compounds for genes affiliated with Eclampsia

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Compounds related to Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ancrod4410.0F5, SERPINC1, SERPINE1
2coumarins449.8F5, MAOA, APOH
3n(g)-nitro-l-arginine methyl ester449.8SOD1, LEP, SERPINE1
4pioglitazone28 44 50 1112.7LEP, VCAM1, SERPINE1, IGFBP1
5tibolone449.7LEP, SERPINE1, SERPINC1, F5
6levonorgestrel44 61 28 1112.7SERPINC1, F5, IGFBP1
7metformin44 50 1111.7SERPINE1, LEP, F5, IGFBP1
8lycopene44 2410.7GSTP1, VCAM1, SOD1
9alpha tocopherol449.6SOD1, LEP, APOH, VCAM1
10progestin449.6IGFBP1, SERPINE1, F5, SERPINC1
11kininogen449.6SERPINC1, SERPINE1, APOH, F5
12p002449.6F5, IGFBP1, FLT1, LEP, APOH
13gnrh449.5SERPINC1, TAC3, LEP, IGFBP1, SERPINE1
14p003449.5LEP, APOH, SERPINE1, HLA-G, FLT1
15sodium nitroprusside449.5LEP, VCAM1, SOD1, SERPINE1
168-isoprostane449.5VCAM1, LEP, APOH, SERPINE1, SOD1
17homocysteine44 2410.5F5, SERPINE1, APOH, VCAM1, SERPINC1
18tamoxifen44 50 28 1112.4F5, IGFBP1, LEP, SERPINC1, VCAM1
19uric acid44 2410.4SOD1, LEP, APOH, SERPINE1, F5
20folate449.4APOH, SERPINC1, GSTP1, VCAM1, F5
21n acetylcysteine449.3LEP, GSTP1, VCAM1, SERPINC1, SOD1
22rosiglitazone28 44 50 24 1113.3LEP, SERPINE1, VCAM1, IGFBP1
23cyclophosphamide44 50 1111.3VCAM1, F5, GSTP1, SERPINE1, APOH
24matrigel449.2HLA-G, FLT1, VCAM1, PGF, SERPINE1
25methotrexate50 44 1111.2HLA-G, LEP, APOH, SERPINE1, GSTP1
26superoxide44 2410.2GSTP1, VCAM1, FLT1, APOH, TAC3, SOD1
27aspirin44 50 28 2412.2SERPINC1, SERPINE1, GSTP1, F5, APOH
28atorvastatin44 50 28 24 1113.2F5, VCAM1, PGF, SERPINE1
29epinephrine44 24 1111.2LEP, IGFBP1, MAOA, GSTP1, F5
30cocaine44 1110.1APOH, VCAM1, F5, LEP
31ascorbic acid44 2410.0F5, GSTP1, MAOA, SOD1, SERPINC1, LEP
32fibrinogen449.0LEP, IGFBP1, SERPINE1, VCAM1, F5, SERPINC1
33progesterone44 28 61 24 1113.0IGFBP1, LEP, APOH, SERPINE1, F5, HLA-G
34lactate448.9IGFBP1, HLA-G, APOH, VCAM1, GSTP1, SOD1
35dexamethasone44 50 28 1111.9SERPINC1, VCAM1, IGFBP1, HLA-G, LEP, MAOA
36paraffin448.8GSTP1, VCAM1, FLT1, PGF, LEP
37cholesterol44 28 24 1111.8SERPINE1, FLT1, VCAM1, F5, LEP, APOH
38arginine448.7IGFBP1, LEP, APOH, SERPINC1, SOD1, VCAM1
39glucose448.6IGFBP1, APOH, PGF, FLT1, VCAM1, SERPINE1
40cysteine448.6GSTP1, IGFBP1, F5, VCAM1, HLA-G, LEP
41oxygen44 249.6IGFBP1, MAOA, VCAM1, FLT1, APOH, SOD1
42testosterone44 61 24 1111.5IGFBP1, LEP, SERPINC1, VCAM1, MAOA, GSTP1
43nitric oxide44 24 1110.3APOH, TAC3, VCAM1, IGFBP1, FLT1, PGF
44serine448.3LEP, VCAM1, F5, GSTP1, CORIN, FLT1
45lipid448.3SERPINE1, LEP, VCAM1, PGF, FLT1, SOD1
46heparin44 28 24 1111.3VCAM1, FLT1, F5, IGFBP1, APOH, SERPINC1
47prostacyclin448.2LEP, APOH, F5, VCAM1, FLT1, PGF
48estrogen447.8IGFBP1, LEP, APOH, SERPINE1, GSTP1, VCAM1
49vegf447.6IGFBP1, HLA-G, LEP, APOH, F5, GSTP1
50creatinine447.6SOD1, GSTP1, PGF, FLT1, HLA-G, LEP

GO Terms for genes affiliated with Eclampsia

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Cellular components related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.6SOD1, SERPINE1, APOH
2extracellular regionGO:0055767.7IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, PGF
3plasma membraneGO:0058867.7HLA-G, SERPINE1, SERPINC1, SOD1, FLT1, VCAM1
4extracellular spaceGO:0056157.0TAC3, IGFBP1, LEP, APOH, SERPINE1, SERPINC1

Biological processes related to Eclampsia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.2VCAM1, LEP
2cellular response to vascular endothelial growth factor stimulusGO:03592410.1VCAM1, FLT1
3positive regulation of superoxide anion generationGO:03293010.1GSTP1, SOD1
4negative regulation of fibrinolysisGO:05191810.1SERPINE1, APOH
5positive regulation of cytokine productionGO:00181910.1SOD1, LEP
6positive regulation of blood coagulationGO:03019410.0APOH, SERPINE1
7negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH
8regulation of blood pressureGO:00821710.0LEP, SOD1, CORIN
9platelet degranulationGO:0025769.8SERPINE1, SOD1, F5
10vascular endothelial growth factor receptor signaling pathwayGO:0480109.8PGF, FLT1
11sprouting angiogenesisGO:0020409.7PGF, FLT1
12positive regulation of angiogenesisGO:0457669.6FLT1, PGF, SERPINE1
13female pregnancyGO:0075659.5TAC3, CORIN, PGF, LEP
14blood coagulationGO:0075969.3F5, SOD1, SERPINC1, SERPINE1
15response to hypoxiaGO:0016669.2VCAM1, PGF, LEP

Molecular functions related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:0081319.6MAOA, VCAM1
2heparin bindingGO:0082019.4PGF, SERPINC1, APOH

Products for genes affiliated with Eclampsia

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Sources for Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet