MCID: ECL001
MIFTS: 64

Eclampsia malady

Rare diseases, Cardiovascular diseases categories

Summaries for Eclampsia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Eclampsia (from the Greek ????????? \"to shine forth\", here in the sense of \"sudden occurrence\") is... more...

MalaCards: Eclampsia, also known as eclampsia in puerperium, is related to pre-eclampsia and severe pre-eclampsia. An important gene associated with Eclampsia is STOX1 (storkhead box 1), and among its related pathways are Dopamine metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drugs nitroglycerin and magnesium sulfate and the compounds ancrod and coumarins have been mentioned in the context of this disorder. Affiliated tissues include endothelial, placenta and testes, and related mouse phenotypes are liver/biliary system and embryogenesis.

Aliases & Classifications for Eclampsia

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

eclampsia 9 44 11 46 63
eclampsia in puerperium 9 63
eclampsia, postpartum 9
eclampsia unspecified 9
postpartum eclampsia 9
eclampsia nos 9


External Ids:

Disease Ontology9 DOID:13593
NCIt41 C87167
MeSH36 D004461
ICD1026 O15, O15.2

Related Diseases for Eclampsia

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18GeneCards, 19GeneDecks
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Diseases related to Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.3STOX1, FLT1, HLA-G
2severe pre-eclampsia31.2APOH, LEP, HLA-G, IGFBP1, F5, GSTP1
3hypertension31.1F5, VCAM1, PGF, SERPINE1, LEP
4hellp syndrome31.0F5, GSTP1, SERPINC1, SERPINE1, APOH
5mild pre-eclampsia30.8SOD1, IGFBP1, VCAM1
6gestational diabetes30.6LEP, PGF, IGFBP1
7placental insufficiency30.5PGF, IGFBP1, FLT1
8placental abruption30.5F5, SERPINC1
9proteinuria30.5FLT1, APOH, HLA-G, PGF
10essential hypertension30.4SERPINE1, SOD1, LEP, HLA-G
11thrombophilia30.3SERPINC1, F5, SERPINE1, APOH
12diabetes mellitus30.3IGFBP1, VCAM1, LEP, SERPINE1, SERPINC1, SOD1
13insulin resistance30.3IGFBP1, VCAM1, LEP, PGF, SERPINE1
14antiphospholipid syndrome30.2VCAM1, SERPINC1, F5, APOH
15pregnancy loss30.2F5, APOH, SERPINC1, HLA-G
16obesity30.1SERPINE1, MAOA, IGFBP1, LEP, FLT1
17thrombocytopenia30.0APOH, F5, SERPINC1
18thromboembolism30.0F5, SERPINE1, APOH, SERPINC1
19breast cancer30.0SERPINE1, HLA-G, LEP, IGFBP1, FLT1, GSTP1
20purpura29.9SERPINC1
21vascular disease29.9APOH, SERPINC1
22portal vein thrombosis29.9F5, SERPINC1
23central retinal vein occlusion29.9APOH, F5
24retinal vein occlusion29.8SERPINC1, APOH, F5
25antithrombin iii deficiency29.8SERPINC1, APOH, F5
26polycystic ovary syndrome29.8SERPINE1, IGFBP1, LEP
27hyperglycemia29.7VCAM1, SOD1, SERPINE1, LEP, IGFBP1
28diabetic retinopathy29.7SERPINE1, SOD1, FLT1, PGF, VCAM1, IGFBP1
29myocardial infarction29.7PGF, IGFBP1, SERPINC1, SERPINE1, F5
30endotheliitis10.8
31blindness10.5
32cortical blindness10.4
33cerebritis10.4
34hypoxia10.4
35retinitis10.3
36hypertensive encephalopathy10.3
37hepatitis10.3
38retinal detachment10.3
39periodontitis10.2
40peripartum cardiomyopathy10.2
41chorioamnionitis10.2
42eales disease10.1SOD1
43retinal artery occlusion10.1APOH
44thrombophlebitis10.1APOH
45intrahepatic cholestasis10.1
46cerebral palsy10.1
47cholestasis10.1
48hemolytic anemia10.1
49pancreatitis10.1
50periodontal disease10.1

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to eclampsia

Symptoms for Eclampsia

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Drugs & Therapeutics for Eclampsia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Eclampsia

Drug clinical trials:

Search ClinicalTrials for Eclampsia

Search NIH Clinical Center for Eclampsia

Search CenterWatch for Eclampsia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Eclampsia

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Anatomical Context for Eclampsia

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34MalaCards
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MalaCards organs/tissues related to Eclampsia:

34
Endothelial, Placenta, Testes, Liver, Nk cells, Breast, Kidney, T cells, Brain, Thyroid, Myeloid, Pancreas, Heart, Pituitary, B cells, Temporal lobe, Occipital lobe, Fetal lung, Monocytes, Ovary, Skin, Lung, Colon, Retina, Whole blood, Eye

Animal Models for Eclampsia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Eclampsia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, F5
2MP:00053808.7F5, VCAM1, FLT1, PGF, SERPINC1, LEP
3MP:00107688.1LEP, APOH, SERPINE1, SERPINC1, SOD1, FLT1
4MP:00053878.1IGFBP1, HLA-G, LEP, SERPINE1, SERPINC1, SOD1
5MP:00107718.0LEP, SERPINE1, PGF, CORIN, GSTP1, F5
6MP:00053787.8LEP, SERPINE1, PGF, FLT1, VCAM1, CORIN
7MP:00053857.6SOD1, SERPINC1, SERPINE1, LEP, PGF, FLT1
8MP:00053767.1F5, HLA-G, LEP, APOH, SERPINE1, SERPINC1

Publications for Eclampsia

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53PubMed
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Articles related to Eclampsia:

(show top 50)    (show all 1397)
idTitleAuthorsYear
1
A report from #BlueJC: Can measuring angiogenic factors help with predicting preterm pre-eclampsia in low-risk women? (24428457)
2014
2
Eclampsia: trends in incidence and outcomes over 30 years. (23271385)
2013
3
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
4
Maternal and perinatal outcomes among women with eclampsia admitted to a tertiary care hospital in Hyderabad, Pakistan. (24135290)
2013
5
A case-control study of placental lesions associated with pre-eclampsia. (23200099)
2013
6
Aspirin for pre-eclampsia: beware of subgroup meta-analysis. (23610032)
2013
7
Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia. (24303960)
2013
8
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
9
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
10
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. (22540831)
2012
11
Improving diagnosis and clinical management of pre-eclampsia. (22452158)
2012
12
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. (22561779)
2012
13
Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia. (22663329)
2012
14
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
15
An unexpected tail of VEGF and PlGF in pre-eclampsia. (22103490)
2011
16
Fractional excretion of urea in pre-eclampsia: a clinical observation. (22057072)
2011
17
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
18
A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes. (21340620)
2011
19
Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)
2011
20
A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. (21973132)
2011
21
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
22
PP13 as a marker of pre-eclampsia: A two platform comparison study. (21257081)
2011
23
Preeclampsia/eclampsia: an insight into the dilemma of treatment by the anesthesiologist. (22052138)
2011
24
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. (21688303)
2011
25
Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsia]. (20140873)
2010
26
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
27
Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (19108943)
2009
28
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
29
Predictors and risk factors of pre-eclampsia. (18854808)
2008
30
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
31
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. (18226121)
2008
32
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
33
Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)
2007
34
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)
2007
35
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
36
Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study. (16455620)
2006
37
Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor-binding sites detected with comparative promoter analysis. (16403800)
2006
38
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
39
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
40
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. (12653685)
2003
41
Soluble adhesion molecules: marker of pre-eclampsia and intrauterine growth restriction. (12422906)
2002
42
Oxidant stress in pre-eclampsia and essential hypertension. (12583464)
2002
43
Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. (11554693)
2001
44
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
45
Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. (9038589)
1997
46
Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro--a possible role in the etiology of pre-eclampsia? (8952225)
1996
47
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension. (8730885)
1996
48
Anticardiolipin antibodies in eclampsia. (1348988)
1992
49
Severe pre-eclampsia of early onset. (6196074)
1983
50
The management of severe pre-eclampsia. (1050623)
1976

Variations for Eclampsia

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Expression for genes affiliated with Eclampsia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for genes affiliated with Eclampsia

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 31KEGG, 54QIAGEN, 55R&D Systems
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Compounds for genes affiliated with Eclampsia

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ancrod4610.0F5, SERPINC1, SERPINE1
2coumarins469.8F5, MAOA, APOH
3n(g)-nitro-l-arginine methyl ester469.8SOD1, LEP, SERPINE1
4pioglitazone30 46 52 1212.7LEP, VCAM1, SERPINE1, IGFBP1
5tibolone469.7LEP, SERPINE1, SERPINC1, F5
6levonorgestrel46 62 30 1212.7SERPINC1, F5, IGFBP1
7metformin46 52 1211.7SERPINE1, LEP, F5, IGFBP1
8lycopene46 2510.7GSTP1, VCAM1, SOD1
9alpha tocopherol469.6SOD1, LEP, APOH, VCAM1
10progestin469.6IGFBP1, SERPINE1, F5, SERPINC1
11kininogen469.6SERPINC1, SERPINE1, APOH, F5
12p002469.6F5, IGFBP1, FLT1, LEP, APOH
13gnrh469.5SERPINC1, TAC3, LEP, IGFBP1, SERPINE1
14p003469.5LEP, APOH, SERPINE1, HLA-G, FLT1
15sodium nitroprusside469.5LEP, VCAM1, SOD1, SERPINE1
168-isoprostane469.5VCAM1, LEP, APOH, SERPINE1, SOD1
17homocysteine46 2510.5F5, SERPINE1, APOH, VCAM1, SERPINC1
18tamoxifen46 52 30 1212.4F5, IGFBP1, LEP, SERPINC1, VCAM1
19uric acid46 2510.4SOD1, LEP, APOH, SERPINE1, F5
20folate469.4APOH, SERPINC1, GSTP1, VCAM1, F5
21n acetylcysteine469.3LEP, GSTP1, VCAM1, SERPINC1, SOD1
22rosiglitazone30 46 52 25 1213.3LEP, SERPINE1, VCAM1, IGFBP1
23cyclophosphamide46 52 1211.3VCAM1, F5, GSTP1, SERPINE1, APOH
24matrigel469.2HLA-G, FLT1, VCAM1, PGF, SERPINE1
25methotrexate52 46 1211.2HLA-G, LEP, APOH, SERPINE1, GSTP1
26superoxide46 2510.2GSTP1, VCAM1, FLT1, APOH, TAC3, SOD1
27aspirin46 52 30 2512.2SERPINC1, SERPINE1, GSTP1, F5, APOH
28atorvastatin46 52 30 25 1213.2F5, VCAM1, PGF, SERPINE1
29epinephrine46 25 1211.2LEP, IGFBP1, MAOA, GSTP1, F5
30cocaine46 1210.1APOH, VCAM1, F5, LEP
31ascorbic acid46 2510.0F5, GSTP1, MAOA, SOD1, SERPINC1, LEP
32fibrinogen469.0LEP, IGFBP1, SERPINE1, VCAM1, F5, SERPINC1
33progesterone46 30 62 25 1213.0IGFBP1, LEP, APOH, SERPINE1, F5, HLA-G
34lactate468.9IGFBP1, HLA-G, APOH, VCAM1, GSTP1, SOD1
35dexamethasone46 52 30 1211.9SERPINC1, VCAM1, IGFBP1, HLA-G, LEP, MAOA
36paraffin468.8GSTP1, VCAM1, FLT1, PGF, LEP
37cholesterol46 30 25 1211.8SERPINE1, FLT1, VCAM1, F5, LEP, APOH
38arginine468.7IGFBP1, LEP, APOH, SERPINC1, SOD1, VCAM1
39glucose468.6IGFBP1, APOH, PGF, FLT1, VCAM1, SERPINE1
40cysteine468.6GSTP1, IGFBP1, F5, VCAM1, HLA-G, LEP
41oxygen46 259.6IGFBP1, MAOA, VCAM1, FLT1, APOH, SOD1
42testosterone46 62 25 1211.5IGFBP1, LEP, SERPINC1, VCAM1, MAOA, GSTP1
43nitric oxide46 25 1210.3APOH, TAC3, VCAM1, IGFBP1, FLT1, PGF
44serine468.3LEP, VCAM1, F5, GSTP1, CORIN, FLT1
45lipid468.3SERPINE1, LEP, VCAM1, PGF, FLT1, SOD1
46heparin46 30 25 1211.3VCAM1, FLT1, F5, IGFBP1, APOH, SERPINC1
47prostacyclin468.2LEP, APOH, F5, VCAM1, FLT1, PGF
48estrogen467.8IGFBP1, LEP, APOH, SERPINE1, GSTP1, VCAM1
49vegf467.6IGFBP1, HLA-G, LEP, APOH, F5, GSTP1
50creatinine467.6SOD1, GSTP1, PGF, FLT1, HLA-G, LEP

GO Terms for genes affiliated with Eclampsia

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17Gene Ontology
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Cellular components related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.6SOD1, SERPINE1, APOH
2extracellular regionGO:0055767.7IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, PGF
3plasma membraneGO:0058867.7HLA-G, SERPINE1, SERPINC1, SOD1, FLT1, VCAM1
4extracellular spaceGO:0056157.0TAC3, IGFBP1, LEP, APOH, SERPINE1, SERPINC1

Biological processes related to Eclampsia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.2VCAM1, LEP
2cellular response to vascular endothelial growth factor stimulusGO:03592410.1VCAM1, FLT1
3positive regulation of superoxide anion generationGO:03293010.1GSTP1, SOD1
4negative regulation of fibrinolysisGO:05191810.1SERPINE1, APOH
5positive regulation of cytokine productionGO:00181910.1SOD1, LEP
6positive regulation of blood coagulationGO:03019410.0APOH, SERPINE1
7negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH
8regulation of blood pressureGO:00821710.0LEP, SOD1, CORIN
9platelet degranulationGO:0025769.8SERPINE1, SOD1, F5
10vascular endothelial growth factor receptor signaling pathwayGO:0480109.8PGF, FLT1
11sprouting angiogenesisGO:0020409.7PGF, FLT1
12positive regulation of angiogenesisGO:0457669.6FLT1, PGF, SERPINE1
13female pregnancyGO:0075659.5TAC3, CORIN, PGF, LEP
14blood coagulationGO:0075969.3F5, SOD1, SERPINC1, SERPINE1
15response to hypoxiaGO:0016669.2VCAM1, PGF, LEP

Molecular functions related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:0081319.6MAOA, VCAM1
2heparin bindingGO:0082019.4PGF, SERPINC1, APOH

Products for genes affiliated with Eclampsia

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  • Antibodies
  • Proteins
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Sources for Eclampsia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet