MCID: ECL001
MIFTS: 63

Eclampsia malady

Summaries for Eclampsia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Eclampsia (Greek for \"shining forth\") is an acute and life-threatening complication of pregnancy... more...

MalaCards: Eclampsia, also known as eclampsia in puerperium, is related to pre-eclampsia and severe pre-eclampsia. An important gene associated with Eclampsia is STOX1 (storkhead box 1), and among its related pathways are HIF-1-alpha transcription factor network and Complement and coagulation cascades. The drugs nitroglycerin and magnesium sulfate and the compounds creatinine and vegf have been mentioned in the context of this disorder. Affiliated tissues include endothelial, placenta and testes, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Eclampsia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

eclampsia 8 42 10 44 60
eclampsia in puerperium 8 60
eclampsia unspecified 8
eclampsia, postpartum 8
postpartum eclampsia 8
eclampsia nos 8


External Ids:

Disease Ontology8 DOID:13593
NCIt39 C87167
MeSH34 D004461
ICD1025 O15, O15.2

Related Diseases for Eclampsia

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17GeneCards, 18GeneDecks
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Diseases related to Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.1HLA-G, STOX1, FLT1
2severe pre-eclampsia31.6IGFBP1, MAOA, PGF, LEP, VCAM1, SERPINE1
3hypertension31.1PGF, LEP, VCAM1, SERPINE1, F5
4hellp syndrome31.0SERPINC1, SERPINE1, F5, APOH
5mild pre-eclampsia30.8SOD1, IGFBP1, VCAM1
6gestational diabetes30.5LSL, IGFBP1, PGF, LEP
7proteinuria30.4PGF, FLT1, HLA-G, APOH, LSL
8thrombophilia30.4SERPINC1, SERPINE1, F5, APOH
9placental insufficiency30.4PGF, IGFBP1, FLT1
10placental abruption30.4SERPINC1, F5
11diabetes mellitus30.3LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1
12essential hypertension30.3SOD1, HLA-G, LEP, SERPINE1
13hepatitis30.3IGFBP1
14obesity30.2LSL, FLT1, IGFBP1, MAOA, LEP, SERPINE1
15chorioamnionitis30.2FLT1
16breast cancer30.1HLA-G, FLT1, IGFBP1, PGF, LEP, SERPINE1
17antiphospholipid syndrome30.1SERPINC1, VCAM1, F5, APOH
18pancreatitis30.1SOD1
19thrombocytopenia29.9APOH, F5, SERPINC1
20myocardial infarction29.7LSL, F5, IGFBP1, PGF, SERPINE1, SERPINC1
21diabetic retinopathy29.7SOD1, FLT1, IGFBP1, PGF, VCAM1, SERPINE1
22vascular disease29.7SOD1, APOH, F5, VCAM1, SERPINE1, SERPINC1
23hyperglycemia29.7LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1
24polycystic ovary syndrome29.7SERPINE1, LEP, IGFBP1, LSL
25ischemia29.7SOD1, FLT1, PGF
26hypogonadism29.7LSL, TAC3, LEP
27retinal vein occlusion29.7APOH, F5, SERPINC1
28antithrombin iii deficiency29.7APOH, F5, SERPINC1
29migraine29.7MAOA, APOH
30vasculitis29.7VCAM1, APOH
31central retinal vein occlusion29.7F5, APOH
32portal vein thrombosis29.7F5, SERPINC1
33hypothyroidism29.7LEP, LSL
34down syndrome29.7PGF, SOD1
35purpura29.7SERPINC1
36lipodystrophy29.7LSL, LEP
37glomerulonephritis29.7VCAM1
38acute pancreatitis29.7SOD1
39cortical blindness10.4
40cerebritis10.4
41retinitis10.3
42hypertensive encephalopathy10.2
43retinal detachment10.2
44periodontitis10.2
45peripartum cardiomyopathy10.1
46intrahepatic cholestasis10.1
47hypertensive retinopathy10.1
48cerebral palsy10.1
49cholestasis10.1
50hemolytic anemia10.1

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to eclampsia

Clinical Features for Eclampsia

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Drugs & Therapeutics for Eclampsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Eclampsia

Drug clinical trials:

Search ClinicalTrials for Eclampsia

Search NIH Clinical Center for Eclampsia

Search CenterWatch for Eclampsia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Eclampsia

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Anatomical Context for Eclampsia

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32MalaCards
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MalaCards organs/tissues related to Eclampsia:

32
Endothelial, Placenta, Testes, Liver, Nk cells, Breast, Kidney, T cells, Brain, Thyroid, Myeloid, Pancreas, Heart, Pituitary, B cells, Temporal lobe, Occipital lobe, Fetal lung, Monocytes, Ovary, Skin, Lung, Colon, Retina, Whole blood, Eye

Animal Models for Eclampsia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.7CORIN, SOD1, APOH, HLA-G, FLT1, F5
2MP:000538511.3VCAM1, CORIN, SOD1, FLT1, MAOA, PGF
3MP:000538711.2SOD1, HLA-G, FLT1, IGFBP1, PGF, LEP
4MP:000537011.1F5, IGFBP1, LEP, SERPINE1, SERPINC1, SOD1

Publications for Eclampsia

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50PubMed
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Articles related to Eclampsia:

(show top 50)    (show all 1409)
idTitleAuthorsYear
1
Contribution of genome-environment interaction to pre-eclampsia in a Havana Maternity Hospital. (23934423)
2013
2
The relationship between pre-eclampsia and peripartum cardiomyopathy: a systematic review and meta-analysis. (24013055)
2013
3
Associations between vascular endothelial growth factor gene polymorphisms and pre-eclampsia susceptibility: a meta-analysis. (23957473)
2013
4
Reproductive endocrinology: Predictive biomarkers of pre-eclampsia in women with T1DM. (24100268)
2013
5
Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population? (23331974)
2013
6
Change in paternity, pre-eclampsia, fetal growth retardation and maternal testosterone concentration. (23445162)
2013
7
Impedance cardiography in uncomplicated pregnancy and pre-eclampsia: a reliability study. (22943706)
2012
8
Cystatin C in pre-eclampsia. (21740322)
2012
9
Risk factors for pre-eclampsia in Mulago Hospital, Kampala, Uganda. (22151898)
2012
10
Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies. (22455350)
2012
11
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
12
Prediction of pre-eclampsia in early pregnancy by estimating the spot urinary albumin: creatinine ratio using high-performance liquid chromatography. (21481153)
2011
13
Impaired vascular permeability regulation caused by the VEGFa88a88a88b splice variant in pre-eclampsia. (21668772)
2011
14
Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. (20192952)
2010
15
Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia. (20013873)
2010
16
Adenosine deaminase activity in subjects with normal pregnancy, pregnancy induced hypertension and pre-eclampsia. (20306731)
2009
17
Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia. (19412349)
2009
18
Increased visfatin and leptin in pregnancies complicated by pre-eclampsia. (19488934)
2009
19
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
20
Efficacy of nitroglycerine infusion versus sublingual nifedipine in severe pre-eclampsia: a randomized, triple-blind, controlled trial. (18070142)
2008
21
Association of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in Iranian patients with pre-eclampsia. (18705845)
2008
22
Celiac serology in women with severe pre-eclampsia or delivery of a small for gestational age neonate. (18632102)
2008
23
RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity. (17845206)
2007
24
Lethal candida sepsis associated with myeloperoxidase deficiency and pre-eclampsia. (17614858)
2007
25
Pre-eclampsia: clinical manifestations and molecular mechanisms. (17570933)
2007
26
Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes. (17179726)
2007
27
Alterations in the 'local umbilical cord blood renin-angiotensin system' during pre-eclampsia. (17851801)
2007
28
Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism? (16829304)
2006
29
Partial molar pregnancy with severe pre-eclampsia at 19 weeks' gestation. (17130046)
2006
30
Increased global fibrinolytic capacity as a clue for activated fibrinolysis in pre-eclampsia. (16788310)
2006
31
Incidence of severe pre-eclampsia, postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a European population-based study: the MOMS-B survey. (15663404)
2005
32
Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood. (16305664)
2005
33
Precursors to pre-eclampsia: are there markers in the fetal circulation? (14989695)
2004
34
Association between HLA-G genotype and risk of pre-eclampsia: a case-control study using family triads. (14985477)
2004
35
Umbilical cord serum vascular endothelial growth factor (VEGF) levels in normal pregnancies and in pregnancies complicated by preterm delivery or pre-eclampsia. (15050460)
2004
36
Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. (12651901)
2003
37
Plasma exchange in a woman with thrombotic thrombocytopenic purpura or severe pre-eclampsia. (12197381)
2002
38
Leptin and pre-eclampsia in black African parturients. (12452464)
2002
39
Functional characteristics of chorionic plate placental arteries from normal pregnant women and women with pre-eclampsia. (12517325)
2002
40
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. (11283205)
2001
41
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
42
The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. (11122327)
2000
43
What is the place of genetics in the pathogenesis of pre-eclampsia? (10567760)
1999
44
Studies on the HLA-DRB1 genotypes in Japanese women with severe pre-eclampsia positive and negative for anticardiolipin antibody using a polymerase chain reaction-restriction fragment length polymorphism method. (10601082)
1999
45
Decrease in cytochrome c oxidase activity detected cytochemically in the placental trophoblast of patients with pre-eclampsia. (9179918)
1997
46
A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. (9150163)
1997
47
Postpartum recovery after severe pre-eclampsia and HELLP-syndrome. (9120747)
1996
48
Pre-eclampsia and gestational age differently alter binding of endothelin-1 to placental and trophoblast membrane preparations. (7672454)
1995
49
An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance. (1550119)
1992
50
Serial plasma oncotic pressure levels and echoencephalography during and after delivery in severe pre-eclampsia. (2860445)
1985

Genetic Variations for Eclampsia

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Expression for genes affiliated with Eclampsia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for genes affiliated with Eclampsia

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems
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Compounds for genes affiliated with Eclampsia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1creatinine4412.1LSL, SOD1, APOH, HLA-G, IGFBP1, FLT1
2vegf4412.1VCAM1, PGF, SERPINE1, IGFBP1, F5, HLA-G
3nitric oxide44 11 2414.0SERPINE1, VCAM1, TAC3, PGF, IGFBP1, F5
4lipid4412.0VCAM1, SOD1, LEP, PGF, HLA-G, FLT1
5prostacyclin4411.9LEP, PGF, SERPINC1, FLT1, APOH, SOD1
6cholesterol44 28 11 2414.9LEP, F5, FLT1, HLA-G, APOH, SERPINE1
7fibrinogen4411.8LEP, SERPINE1, VCAM1, SERPINC1, IGFBP1, F5
8progesterone44 59 28 11 2415.8HLA-G, FLT1, F5, IGFBP1, LEP, APOH
9testosterone44 59 11 2414.8LEP, MAOA, SERPINC1, SERPINE1, VCAM1, IGFBP1
10arginine4411.7LEP, SOD1, IGFBP1, F5, APOH, LSL
11lactate4411.6IGFBP1, APOH, SOD1, LSL, F5, VCAM1
12homocysteine44 2412.6SERPINC1, APOH, F5, LSL, SERPINE1, VCAM1
13p0024411.6LSL, APOH, FLT1, F5, IGFBP1, LEP
14phosphatidylinositol4411.5LSL, APOH, FLT1, IGFBP1, PGF, VCAM1
15tibolone4411.5F5, LEP, SERPINE1, SERPINC1, LSL
168-isoprostane4411.5APOH, LEP, VCAM1, SERPINE1, SOD1
17p0034411.5FLT1, HLA-G, APOH, LSL, SERPINE1
18metformin44 49 1113.4IGFBP1, LEP, SERPINE1, F5, LSL
19oxygen44 2412.4FLT1, IGFBP1, PGF, HLA-G, MAOA
20copper44 2412.4SOD1, APOH, F5, IGFBP1, LSL
21heparin44 28 11 2414.4APOH, PGF, FLT1, VCAM1
22methotrexate44 49 1113.3APOH, LSL, LEP, SERPINE1, HLA-G
23rosiglitazone44 49 28 11 2415.3VCAM1, LSL, IGFBP1, LEP
24citalopram49 44 11 2414.3LEP, MAOA, SERPINE1, LSL
25raloxifene44 28 49 1114.3F5, SERPINC1, SERPINE1, LSL
26kininogen4411.2SERPINE1, F5, APOH, SERPINC1
27uric acid44 2412.2APOH, F5, SERPINE1
28glucose4411.2PGF, FLT1, LSL, APOH
29c-peptide4411.2LSL, IGFBP1, LEP, SERPINE1
30malondialdehyde4411.2APOH, LSL, F5, SOD1
31pioglitazone44 49 28 1114.2IGFBP1, LEP, VCAM1, SERPINE1
32tamoxifen44 49 28 1114.2IGFBP1, VCAM1, LSL
33epinephrine44 11 2413.2F5, MAOA, IGFBP1, LSL, LEP
34ancrod4411.2SERPINE1, SERPINC1, F5
35pravastatin44 49 28 11 2415.2SERPINE1, LSL, LEP, VCAM1
36estrogen4411.1TAC3, APOH
37progestin4411.1F5, IGFBP1, SERPINE1, SERPINC1
38beta-hydroxybutyrate4411.1LSL, IGFBP1, LEP
39gnrh4411.1IGFBP1, TAC3
40matrigel4411.1SERPINE1, PGF, HLA-G, FLT1
41ascorbic acid44 2412.1SOD1, MAOA, LEP, SERPINC1, F5
42superoxide44 2412.1VCAM1, TAC3, APOH
43coumarins4411.0APOH, MAOA
44dexamethasone44 49 28 1114.0MAOA
45p0054410.9PGF
46n(g)-nitro-l-arginine methyl ester4410.9SOD1, LEP, SERPINE1
47atorvastatin44 49 28 11 2414.9PGF, VCAM1, SERPINE1, F5
48sodium nitroprusside4410.8SERPINE1, SOD1, LEP, VCAM1
49alpha tocopherol4410.6APOH
50levonorgestrel44 59 28 1113.5F5, IGFBP1, SERPINC1

GO Terms for genes affiliated with Eclampsia

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16Gene Ontology
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Cellular components related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.5SOD1, F5, IGFBP1, PGF, TAC3, LEP
2extracellular spaceGO:00561511.4SERPINC1, SOD1, APOH, FLT1, F5, IGFBP1

Biological processes related to Eclampsia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00756511.1LEP, TAC3, PGF, CORIN
2regulation of blood pressureGO:00821711.0CORIN, SOD1, LEP
3platelet degranulationGO:00257610.9SOD1, F5, SERPINE1
4negative regulation of fibrinolysisGO:05191810.8SERPINE1, APOH
5leukocyte tethering or rollingGO:05090110.7LEP, VCAM1
6negative regulation of blood coagulationGO:03019510.7SERPINE1, APOH
7positive regulation of blood coagulationGO:03019410.6APOH, SERPINE1
8positive regulation of angiogenesisGO:04576610.5FLT1, PGF, SERPINE1

Molecular functions related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.7VCAM1, MAOA

Products for genes affiliated with Eclampsia

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet