Aliases & Classifications for Eclampsia

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Aliases & Descriptions for Eclampsia:

Name: Eclampsia 8 42 10 44 61
Eclampsia in Puerperium 8 61
 
Eclampsia, Postpartum 8
Postpartum Eclampsia 8


Classifications:



External Ids:

Disease Ontology8 DOID:13593
MeSH33 D004461
NCIt39 C87167
ICD1025 O15, O15.2

Summaries for Eclampsia

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Wikipedia:64 Eclampsia is the onset of seizures (convulsions) in a woman with preeclampsia. Preeclampsia is a... more...

MalaCards based summary: Eclampsia, also known as eclampsia in puerperium, is related to pre-eclampsia and mild pre-eclampsia. An important gene associated with Eclampsia is STOX1 (storkhead box 1), and among its related pathways are Dopamine metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drugs nitroglycerin and magnesium sulfate and the compounds ancrod and coumarins have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and kidney, and related mouse phenotypes are liver/biliary system and embryogenesis.

Related Diseases for Eclampsia

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Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.8STOX1, FLT1, HLA-G
2mild pre-eclampsia31.3SOD1, IGFBP1, VCAM1
3placental abruption31.0F5, SERPINC1
4placental insufficiency30.9PGF, IGFBP1, FLT1
5hellp syndrome30.6F5, GSTP1, SERPINC1, SERPINE1, APOH
6proteinuria30.6FLT1, APOH, HLA-G, PGF
7vascular disease30.5APOH, SERPINC1
8purpura30.4SERPINC1
9antiphospholipid syndrome30.3VCAM1, SERPINC1, F5, APOH
10portal vein thrombosis30.2F5, SERPINC1
11central retinal vein occlusion30.2APOH, F5
12choriocarcinoma30.2HLA-G, PGF, LEP, FLT1
13thrombophilia30.2SERPINC1, F5, SERPINE1, APOH
14kidney disease30.2SERPINE1, SERPINC1, VCAM1
15thrombocytopenia30.1APOH, F5, SERPINC1
16retinal vein occlusion30.0SERPINC1, APOH, F5
17polycystic ovary syndrome29.9SERPINE1, IGFBP1, LEP
18infertility29.9LEP, HLA-G, IGFBP1
19obesity29.7SERPINE1, MAOA, IGFBP1, LEP, FLT1
20hyperglycemia29.6VCAM1, SOD1, SERPINE1, LEP, IGFBP1
21severe pre-eclampsia29.6APOH, LEP, HLA-G, IGFBP1, F5, GSTP1
22myocardial infarction29.5PGF, IGFBP1, SERPINC1, SERPINE1, F5
23breast cancer29.4SERPINE1, HLA-G, LEP, IGFBP1, FLT1, GSTP1
24preeclampsia/eclampsia 128.4TAC3, SERPINC1, SERPINE1, APOH, LEP, HLA-G
25endotheliitis10.8
26blindness10.5
27eales disease10.5SOD1
28retinal artery occlusion10.5APOH
29thrombophlebitis10.5APOH
30hypoxia10.5
31cortical blindness10.4
32cerebritis10.4
33retinal vasculitis10.4APOH
34branch retinal artery occlusion10.4F5
35retinitis10.4
36carotid artery thrombosis10.4SERPINE1
37sneddon syndrome10.3APOH, SERPINC1
38microvascular complications of diabetes 110.3IGFBP1, FLT1, VCAM1
39meningococcemia10.3SERPINC1, F5
40protein-energy malnutrition10.3IGFBP1, LEP
41retinal detachment10.3
42post-thrombotic syndrome10.3F5, SERPINC1
43legg-calve-perthes disease10.3F5, SERPINC1
44patent foramen ovale10.3F5
45sagittal sinus thrombosis10.3SERPINC1, F5
46preeclampsia/eclampsia 510.3
47hypertensive encephalopathy10.3
48coronary thrombosis10.3SERPINC1, SERPINE1
49blood protein disease10.3F5, SERPINC1
50anovulation10.3IGFBP1, LEP

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to eclampsia

Symptoms for Eclampsia

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Drugs & Therapeutics for Eclampsia

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Drug clinical trials:

Search ClinicalTrials for Eclampsia

Search NIH Clinical Center for Eclampsia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Eclampsia

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Anatomical Context for Eclampsia

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MalaCards organs/tissues related to Eclampsia:

31
Placenta, Endothelial, Kidney, Testes, Liver, Neutrophil, Breast, Nk cells, Brain, Thyroid, T cells, Eye, Heart, Pancreas, Myeloid, Monocytes, Pituitary, Whole blood, Retina, Colon, Lung, Skin, Ovary, B cells, Temporal lobe, Occipital lobe, Fetal lung

Animal Models for Eclampsia or affiliated genes

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MGI Mouse Phenotypes related to Eclampsia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9LEP, SERPINE1, SERPINC1, SOD1, F5, IGFBP1
2MP:00053808.7LEP, SERPINC1, FLT1, VCAM1, F5, PGF
3MP:00107688.1LEP, F5, VCAM1, FLT1, SOD1, SERPINC1
4MP:00053878.1IGFBP1, HLA-G, SERPINE1, LEP, VCAM1, FLT1
5MP:00107718.0CORIN, GSTP1, F5, SERPINE1, LEP, PGF
6MP:00053787.8FLT1, LEP, SERPINE1, PGF, F5, GSTP1
7MP:00053857.6LEP, SERPINE1, SOD1, PGF, F5, MAOA
8MP:00053767.1APOH, SOD1, HLA-G, F5, MAOA, CORIN

Publications for Eclampsia

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Articles related to Eclampsia:

(show top 50)    (show all 1457)
idTitleAuthorsYear
1
Comparison of serum maternal adiponectin concentrations in women with isolated intrauterine growth retardation and intrauterine growth retardation concomitant with pre-eclampsia. (25317046)
2014
2
A report from #BlueJC: Can measuring angiogenic factors help with predicting preterm pre-eclampsia in low-risk women? (24428457)
2014
3
Eclampsia: trends in incidence and outcomes over 30 years. (23271385)
2013
4
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
5
Maternal and perinatal outcomes among women with eclampsia admitted to a tertiary care hospital in Hyderabad, Pakistan. (24135290)
2013
6
A case-control study of placental lesions associated with pre-eclampsia. (23200099)
2013
7
Aspirin for pre-eclampsia: beware of subgroup meta-analysis. (23610032)
2013
8
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
9
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
10
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. (22540831)
2012
11
Improving diagnosis and clinical management of pre-eclampsia. (22452158)
2012
12
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. (22561779)
2012
13
Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia. (22663329)
2012
14
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
15
An unexpected tail of VEGF and PlGF in pre-eclampsia. (22103490)
2011
16
Fractional excretion of urea in pre-eclampsia: a clinical observation. (22057072)
2011
17
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
18
A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes. (21340620)
2011
19
Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)
2011
20
A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. (21973132)
2011
21
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
22
PP13 as a marker of pre-eclampsia: A two platform comparison study. (21257081)
2011
23
Preeclampsia/eclampsia: an insight into the dilemma of treatment by the anesthesiologist. (22052138)
2011
24
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. (21688303)
2011
25
Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsia]. (20140873)
2010
26
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
27
Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (19108943)
2009
28
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
29
Predictors and risk factors of pre-eclampsia. (18854808)
2008
30
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
31
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. (18226121)
2008
32
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
33
Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)
2007
34
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)
2007
35
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
36
Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study. (16455620)
2006
37
Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor-binding sites detected with comparative promoter analysis. (16403800)
2006
38
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
39
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
40
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. (12653685)
2003
41
Soluble adhesion molecules: marker of pre-eclampsia and intrauterine growth restriction. (12422906)
2002
42
Oxidant stress in pre-eclampsia and essential hypertension. (12583464)
2002
43
Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. (11554693)
2001
44
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
45
Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. (9038589)
1997
46
Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro--a possible role in the etiology of pre-eclampsia? (8952225)
1996
47
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension. (8730885)
1996
48
Anticardiolipin antibodies in eclampsia. (1348988)
1992
49
Severe pre-eclampsia of early onset. (6196074)
1983
50
The management of severe pre-eclampsia. (1050623)
1976

Variations for Eclampsia

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Expression for genes affiliated with Eclampsia

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Search GEO for disease gene expression data for Eclampsia.

Pathways for genes affiliated with Eclampsia

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Compounds for genes affiliated with Eclampsia

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Compounds related to Eclampsia according to GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ancrod4410.0F5, SERPINC1, SERPINE1
2coumarins449.8F5, MAOA, APOH
3n(g)-nitro-l-arginine methyl ester449.8SOD1, LEP, SERPINE1
4pioglitazone28 44 50 1112.7LEP, VCAM1, SERPINE1, IGFBP1
5tibolone449.7LEP, SERPINE1, SERPINC1, F5
6levonorgestrel44 60 28 1112.7SERPINC1, F5, IGFBP1
7metformin44 50 1111.7SERPINE1, LEP, F5, IGFBP1
8lycopene44 2410.7GSTP1, VCAM1, SOD1
9alpha tocopherol449.6SOD1, LEP, APOH, VCAM1
10progestin449.6IGFBP1, SERPINE1, F5, SERPINC1
11kininogen449.6SERPINC1, SERPINE1, APOH, F5
12p002449.6F5, IGFBP1, FLT1, LEP, APOH
13gnrh449.5SERPINC1, TAC3, LEP, IGFBP1, SERPINE1
14p003449.5LEP, APOH, SERPINE1, HLA-G, FLT1
15sodium nitroprusside449.5LEP, VCAM1, SOD1, SERPINE1
168-isoprostane449.5VCAM1, LEP, APOH, SERPINE1, SOD1
17homocysteine44 2410.5F5, SERPINE1, APOH, VCAM1, SERPINC1
18tamoxifen44 50 28 1112.4F5, IGFBP1, LEP, SERPINC1, VCAM1
19uric acid44 2410.4SOD1, LEP, APOH, SERPINE1, F5
20folate449.4APOH, SERPINC1, GSTP1, VCAM1, F5
21n acetylcysteine449.3LEP, GSTP1, VCAM1, SERPINC1, SOD1
22rosiglitazone28 44 50 24 1113.3LEP, SERPINE1, VCAM1, IGFBP1
23cyclophosphamide44 50 1111.3VCAM1, F5, GSTP1, SERPINE1, APOH
24matrigel449.2HLA-G, FLT1, VCAM1, PGF, SERPINE1
25methotrexate50 44 1111.2HLA-G, LEP, APOH, SERPINE1, GSTP1
26superoxide44 2410.2GSTP1, VCAM1, FLT1, APOH, TAC3, SOD1
27aspirin44 50 28 2412.2SERPINC1, SERPINE1, GSTP1, F5, APOH
28atorvastatin44 50 28 24 1113.2F5, VCAM1, PGF, SERPINE1
29epinephrine44 24 1111.2LEP, IGFBP1, MAOA, GSTP1, F5
30cocaine44 1110.1APOH, VCAM1, F5, LEP
31ascorbic acid44 2410.0F5, GSTP1, MAOA, SOD1, SERPINC1, LEP
32fibrinogen449.0LEP, IGFBP1, SERPINE1, VCAM1, F5, SERPINC1
33progesterone44 28 60 24 1113.0IGFBP1, LEP, APOH, SERPINE1, F5, HLA-G
34lactate448.9IGFBP1, HLA-G, APOH, VCAM1, GSTP1, SOD1
35dexamethasone44 50 28 1111.9SERPINC1, VCAM1, IGFBP1, HLA-G, LEP, MAOA
36paraffin448.8GSTP1, VCAM1, FLT1, PGF, LEP
37cholesterol44 28 24 1111.8SERPINE1, FLT1, VCAM1, F5, LEP, APOH
38arginine448.7IGFBP1, LEP, APOH, SERPINC1, SOD1, VCAM1
39glucose448.6IGFBP1, APOH, PGF, FLT1, VCAM1, SERPINE1
40cysteine448.6GSTP1, IGFBP1, F5, VCAM1, HLA-G, LEP
41oxygen44 249.6IGFBP1, MAOA, VCAM1, FLT1, APOH, SOD1
42testosterone44 60 24 1111.5IGFBP1, LEP, SERPINC1, VCAM1, MAOA, GSTP1
43nitric oxide44 24 1110.3APOH, TAC3, VCAM1, IGFBP1, FLT1, PGF
44serine448.3LEP, VCAM1, F5, GSTP1, CORIN, FLT1
45lipid448.3SERPINE1, LEP, VCAM1, PGF, FLT1, SOD1
46heparin44 28 24 1111.3VCAM1, FLT1, F5, IGFBP1, APOH, SERPINC1
47prostacyclin448.2LEP, APOH, F5, VCAM1, FLT1, PGF
48estrogen447.8IGFBP1, LEP, APOH, SERPINE1, GSTP1, VCAM1
49vegf447.6IGFBP1, HLA-G, LEP, APOH, F5, GSTP1
50creatinine447.6SOD1, GSTP1, PGF, FLT1, HLA-G, LEP

GO Terms for genes affiliated with Eclampsia

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Cellular components related to Eclampsia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.6SOD1, SERPINE1, APOH
2extracellular regionGO:00055767.7IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, PGF
3plasma membraneGO:00058867.7HLA-G, SERPINE1, SERPINC1, SOD1, FLT1, VCAM1
4extracellular spaceGO:00056157.0TAC3, IGFBP1, LEP, APOH, SERPINE1, SERPINC1

Biological processes related to Eclampsia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:005090110.2VCAM1, LEP
2cellular response to vascular endothelial growth factor stimulusGO:003592410.1VCAM1, FLT1
3positive regulation of superoxide anion generationGO:003293010.1GSTP1, SOD1
4negative regulation of fibrinolysisGO:005191810.1SERPINE1, APOH
5positive regulation of cytokine productionGO:000181910.1SOD1, LEP
6positive regulation of blood coagulationGO:003019410.0APOH, SERPINE1
7negative regulation of blood coagulationGO:003019510.0SERPINE1, APOH
8regulation of blood pressureGO:000821710.0LEP, SOD1, CORIN
9platelet degranulationGO:00025769.8SERPINE1, SOD1, F5
10vascular endothelial growth factor receptor signaling pathwayGO:00480109.8PGF, FLT1
11sprouting angiogenesisGO:00020409.7PGF, FLT1
12positive regulation of angiogenesisGO:00457669.6FLT1, PGF, SERPINE1
13female pregnancyGO:00075659.5TAC3, CORIN, PGF, LEP
14blood coagulationGO:00075969.3F5, SOD1, SERPINC1, SERPINE1
15response to hypoxiaGO:00016669.2VCAM1, PGF, LEP

Molecular functions related to Eclampsia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00081319.6MAOA, VCAM1
2heparin bindingGO:00082019.4PGF, SERPINC1, APOH

Sources for Eclampsia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet