MCID: ECL001
MIFTS: 62

Eclampsia malady

Summaries for Eclampsia

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Eclampsia (Greek for \"shining forth\") is an acute and life-threatening complication of pregnancy,... more...

MalaCards: Eclampsia, also known as eclampsia in puerperium, is related to hellp syndrome and mild pre-eclampsia. An important gene associated with Eclampsia is STOX1 (storkhead box 1), and among its related pathways are HIF-1-alpha transcription factor network and Formation of Fibrin Clot (Clotting Cascade). The drugs nitroglycerin and magnesium sulfate and the compounds creatinine and vegf have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and retina, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Eclampsia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

eclampsia 8 43 10 45 61
eclampsia in puerperium 8 61
eclampsia unspecified 8
eclampsia, postpartum 8
postpartum eclampsia 8
eclampsia nos 8


External Ids:

Disease Ontology8 DOID:13593
NCIt40 C87167
MeSH35 D004461
ICD1025 O15, O15.2

Related Diseases for Eclampsia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1hellp syndrome31.1SERPINC1, SERPINE1, F5, APOH
2mild pre-eclampsia30.6SOD1, IGFBP1, VCAM1
3gestational diabetes30.6LSL, IGFBP1, PGF, LEP
4thrombophilia30.4SERPINC1, SERPINE1, F5, APOH
5placental insufficiency30.4PGF, IGFBP1, FLT1
6placental abruption30.4SERPINC1, F5
7insulin resistance30.3LSL, IGFBP1, PGF, LEP, VCAM1, SERPINE1
8chorioamnionitis30.2FLT1
9antiphospholipid syndrome30.1SERPINC1, VCAM1, F5, APOH
10pregnancy loss30.1APOH, HLA-G, F5, SERPINC1
11down syndrome30.1PGF, SOD1
12thromboembolism30.0SERPINC1, SERPINE1, F5, APOH
13sepsis30.0LSL, F5, SERPINE1, SERPINC1
14thrombocytopenia30.0APOH, F5, SERPINC1
15vascular disease29.8SOD1, APOH, F5, VCAM1, SERPINE1, SERPINC1
16polycystic ovary syndrome29.8SERPINE1, LEP, IGFBP1, LSL
17vasculitis29.8VCAM1, APOH
18central retinal vein occlusion29.8F5, APOH
19portal vein thrombosis29.8F5, SERPINC1
20nephritis29.8VCAM1, APOH
21lupus nephritis29.8VCAM1, APOH
22acute pancreatitis29.8SOD1
23blindness10.5
24cortical blindness10.4
25hypoxia10.4
26hypertensive encephalopathy10.2
27n syndrome10.2
28preeclampsia/eclampsia 210.2
29peripartum cardiomyopathy10.2
30intrahepatic cholestasis10.1
31triploidy10.1
32preeclampsia/eclampsia 110.1
33preeclampsia/eclampsia 310.1
34preeclampsia/eclampsia 410.1
35quadriplegia10.0
36hypertensive retinopathy10.0
37micro syndrome10.0
38char syndrome10.0
39preeclampsia/eclampsia 510.0
40venous thromboembolism10.0
41severe pre-eclampsia10.0IGFBP1, MAOA, PGF, LEP, VCAM1, SERPINE1
42atherosclerosis10.0CORIN, LSL, SOD1, APOH, FLT1, PGF
43diabetes mellitus10.0LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1
44myocardial infarction10.0LSL, F5, IGFBP1, PGF, SERPINE1, SERPINC1
45hyperhomocysteinemia10.0SOD1, APOH, F5, VCAM1, SERPINE1, SERPINC1
46diabetic retinopathy10.0SOD1, FLT1, IGFBP1, PGF, VCAM1, SERPINE1
47obesity10.0LSL, FLT1, IGFBP1, MAOA, LEP, SERPINE1
48factor v leiden thrombophilia10.0FLT1, F5, IGFBP1, PGF, SERPINE1, SERPINC1
49hyperglycemia10.0LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1
50type 2 diabetes mellitus10.0LSL, SOD1, IGFBP1, LEP, VCAM1, SERPINE1

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to eclampsia

Clinical Features for Eclampsia

Drugs & Therapeutics for Eclampsia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eclampsia

Drug clinical trials:

Search ClinicalTrials for Eclampsia

Search NIH Clinical Center for Eclampsia

Search CenterWatch for Eclampsia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Eclampsia

Anatomical Context for Eclampsia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Eclampsia:

33
Whole blood, Brain, Retina, Spinal cord, Heart, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Placenta, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Occipital lobe, Fetal liver, Fetal lung, Fetal thyroid, Pituitary

Animal Models for Eclampsia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Eclampsia

Sources:
51PubMed
See all sources

Articles related to Eclampsia:

(show top 50)    (show all 1410)
idTitleAuthorsYear
1
Post-partum recovery course in patients with gestational hypertension and pre-eclampsia. (24428339)
2014
2
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
3
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. (23888485)
2013
4
Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria. (23983493)
2013
5
Does microalbuminuria at mid-pregnancy predict development of subsequent pre-eclampsia? (22925380)
2013
6
The relationship of serum vitamin D with pre-eclampsia in the Iranian women. (23782626)
2013
7
A Proteomic Analysis of Placental Trophoblastic Cells in Preeclampsia-Eclampsia. (24343450)
2013
8
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. (22282588)
2012
9
Biomarkers in pre-eclampsia: a novel approach to early detection of the disease. (22943702)
2012
10
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia. (22886584)
2012
11
miR-16 inhibits the proliferation and angiogenesis-regulating potential of mesenchymal stem cells in severe pre-eclampsia. (23083510)
2012
12
Prediction of pre-eclampsia during early pregnancy in primiparas with soluble fms-like tyrosine kinase-1 and placental growth factor. (22686711)
2012
13
Hypoxia inducible factor-1I+ gene polymorphisms in Korean patients with pre-eclampsia. (21979130)
2012
14
Association between osteoprotegerin gene polymorphisms and severe pre-eclampsia in Chinese women]. (22455689)
2012
15
Endothelial FOS expression and pre-eclampsia. (23121125)
2012
16
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
17
A comprehensive survey of miRNA repertoire and 3' addition events in the placentas of patients with pre-eclampsia from high-throughput sequencing. (21731650)
2011
18
Clinical risk prediction of pre-eclampsia. (21474516)
2011
19
Pre-eclampsia: pathophysiology, diagnosis, and management. (21822394)
2011
20
Serum levels of lipids, lipoproteins and paraoxonase activity in pre-eclampsia. (21986144)
2011
21
Early screening for pre-eclampsia and intrauterine growth restriction. (21520318)
2011
22
Lactic dehydrogenase: a biochemical marker for preeclampsia-eclampsia. (23204682)
2011
23
Genetic polymorphisms of vascular endothelial growth factor in pre-eclampsia]. (22012426)
2011
24
Retinal detachment in association with pre-eclampsia, eclampsia, and HELLP syndrome. (21719013)
2011
25
The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease. (20110611)
2010
26
Microarray analysis of differentially expressed fetal genes in placental tissue derived from early and late onset severe pre-eclampsia. (16860862)
2007
27
Mannose-binding lectin genotypes and pre-eclampsia: a case-control study. (18082567)
2007
28
Oxidative stress is closely related to clinical severity of pre-eclampsia. (16874398)
2006
29
Immunoregulation in normal pregnancy and pre-eclampsia: an overview. (17169180)
2006
30
The -56T HLA-G promoter polymorphism is not associated with pre-eclampsia/eclampsia in Australian and New Zealand women. (16867913)
2006
31
Maternal cytokine production patterns in women with pre-eclampsia. (15948770)
2005
32
A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. (15775999)
2005
33
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
34
Recent progress in the therapeutic management of pre-eclampsia. (15500369)
2004
35
Microalbuminuria in pregnancy as a predictor of preeclampsia and eclampsia. (15008291)
2003
36
Elevated tissue plasminogen activator as a potential marker of endothelial dysfunction in pre-eclampsia: correlation with proteinuria. (12452463)
2002
37
Interventionist versus expectant care for severe pre-eclampsia before term. (12137674)
2002
38
Semicarbazide-sensitive amine oxidase in pre-eclampsia: no relation with markers of endothelial cell activation. (12204422)
2002
39
Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia. (11754000)
2002
40
Apolipoprotein E alleles in women with pre-eclampsia. (11477126)
2001
41
Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia. (10611266)
2000
42
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. (10441346)
1999
43
Role of the IGF system in trophoblast invasion and pre-eclampsia. (10690804)
1999
44
Soluble adhesion molecules in patients with pre-eclampsia]. (9659698)
1998
45
Liver and renal and platelet counts after delivery in patients with severe pre-eclampsia. (9930259)
1998
46
Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre-eclampsia. (9013097)
1996
47
Antithrombin ii in eclampsia: estimation of predictive value]. (1345066)
1992
48
Treatment of severe pre-eclampsia by acetyl salicylic acid. (2064587)
1991
49
The management of severe pre-eclampsia and eclampsia. (831744)
1977
50
Spontaneous hematoma of the liver in a woman with severe pre-eclampsia. (13016689)
1953

Genetic Variations for Eclampsia

Expression for genes affiliated with Eclampsia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for genes affiliated with Eclampsia

Sources:
38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 30KEGG
See all sources

Compounds for genes affiliated with Eclampsia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1creatinine4512.1LSL, SOD1, APOH, HLA-G, IGFBP1, FLT1
2vegf4512.1VCAM1, PGF, SERPINE1, IGFBP1, F5, HLA-G
3nitric oxide45 11 2414.0SERPINE1, VCAM1, TAC3, PGF, IGFBP1, F5
4lipid4512.0VCAM1, SOD1, LEP, PGF, HLA-G, FLT1
5prostacyclin4511.9LEP, PGF, SERPINC1, FLT1, APOH, SOD1
6cholesterol45 29 11 2414.9LEP, F5, FLT1, HLA-G, APOH, SERPINE1
7fibrinogen4511.8LEP, SERPINE1, VCAM1, SERPINC1, IGFBP1, F5
8progesterone45 60 29 11 2415.8HLA-G, FLT1, F5, IGFBP1, LEP, APOH
9testosterone45 60 11 2414.8LEP, MAOA, SERPINC1, SERPINE1, VCAM1, IGFBP1
10arginine4511.7LEP, SOD1, IGFBP1, F5, APOH, LSL
11lactate4511.6IGFBP1, APOH, SOD1, LSL, F5, VCAM1
12homocysteine45 2412.6SERPINC1, APOH, F5, LSL, SERPINE1, VCAM1
13p0024511.6LSL, APOH, FLT1, F5, IGFBP1, LEP
14phosphatidylinositol4511.5LSL, APOH, FLT1, IGFBP1, PGF, VCAM1
15tibolone4511.5F5, LEP, SERPINE1, SERPINC1, LSL
168-isoprostane4511.5APOH, LEP, VCAM1, SERPINE1, SOD1
17p0034511.5FLT1, HLA-G, APOH, LSL, SERPINE1
18metformin45 50 1113.4IGFBP1, LEP, SERPINE1, F5, LSL
19oxygen45 2412.4FLT1, IGFBP1, PGF, HLA-G, MAOA
20copper45 2412.4SOD1, APOH, F5, IGFBP1, LSL
21heparin45 29 11 2414.4APOH, PGF, FLT1, VCAM1
22methotrexate45 50 1113.3APOH, LSL, LEP, SERPINE1, HLA-G
23rosiglitazone45 50 29 11 2415.3VCAM1, LSL, IGFBP1, LEP
24citalopram50 45 11 2414.3LEP, MAOA, SERPINE1, LSL
25raloxifene45 29 50 1114.3F5, SERPINC1, SERPINE1, LSL
26kininogen4511.2SERPINE1, F5, APOH, SERPINC1
27uric acid45 2412.2APOH, F5, SERPINE1
28glucose4511.2PGF, FLT1, LSL, APOH
29c-peptide4511.2LSL, IGFBP1, LEP, SERPINE1
30malondialdehyde4511.2APOH, LSL, F5, SOD1
31pioglitazone45 50 29 1114.2IGFBP1, LEP, VCAM1, SERPINE1
32tamoxifen45 50 29 1114.2IGFBP1, VCAM1, LSL
33epinephrine45 11 2413.2F5, MAOA, IGFBP1, LSL, LEP
34ancrod4511.2SERPINE1, SERPINC1, F5
35pravastatin45 50 29 11 2415.2SERPINE1, LSL, LEP, VCAM1
36estrogen4511.1TAC3, APOH
37progestin4511.1F5, IGFBP1, SERPINE1, SERPINC1
38beta-hydroxybutyrate4511.1LSL, IGFBP1, LEP
39gnrh4511.1IGFBP1, TAC3
40matrigel4511.1SERPINE1, PGF, HLA-G, FLT1
41ascorbic acid45 2412.1SOD1, MAOA, LEP, SERPINC1, F5
42superoxide45 2412.1VCAM1, TAC3, APOH
43coumarins4511.0APOH, MAOA
44dexamethasone45 50 29 1114.0MAOA
45p0054510.9PGF
46n(g)-nitro-l-arginine methyl ester4510.9SOD1, LEP, SERPINE1
47atorvastatin45 50 29 11 2414.9PGF, VCAM1, SERPINE1, F5
48sodium nitroprusside4510.8SERPINE1, SOD1, LEP, VCAM1
49alpha tocopherol4510.6APOH
50levonorgestrel45 60 29 1113.5F5, IGFBP1, SERPINC1

GO Terms for genes affiliated with Eclampsia

Sources:
16Gene Ontology
See all sources

Cellular components related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.5SOD1, F5, IGFBP1, PGF, TAC3, LEP
2extracellular spaceGO:00561511.4SERPINC1, SOD1, APOH, FLT1, F5, IGFBP1

Biological processes related to Eclampsia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00756511.1LEP, TAC3, PGF, CORIN
2regulation of blood pressureGO:00821711.0CORIN, SOD1, LEP
3platelet degranulationGO:00257610.9SOD1, F5, SERPINE1
4negative regulation of fibrinolysisGO:05191810.8SERPINE1, APOH
5leukocyte tethering or rollingGO:05090110.7LEP, VCAM1
6negative regulation of blood coagulationGO:03019510.7SERPINE1, APOH
7positive regulation of blood coagulationGO:03019410.6APOH, SERPINE1
8positive regulation of angiogenesisGO:04576610.5FLT1, PGF, SERPINE1

Molecular functions related to Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.7VCAM1, MAOA

Products for genes affiliated with Eclampsia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eclampsia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet