Ectopic Pregnancy malady

MedlinePlus: The uterus, or womb, is an important female reproductive organ. it is the place where a baby grows when a woman is pregnant. if you have an ectopic pregnancy, the fertilized egg grows in an abnormal place, outside the uterus, usually in the fallopian tubes. the result is usually a miscarriage. ectopic pregnancy can be a medical emergency if it ruptures. signs of ectopic pregnancy include abdominal pain shoulder pain vaginal bleeding feeling dizzy or faint get medical care right away if you have these signs. doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. many women who have had ectopic pregnancies go on to have healthy pregnancies later. dept. of health and human services office on women's health²³

MalaCards: Ectopic Pregnancy, also known as pregnancy ectopic, is related to creatine phosphokinase and teratoma. An important gene associated with Ectopic Pregnancy is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Breast Cancer Regulation by Stathmin1. The compounds glucose and oestriol have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, ovary and uterus, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: An ectopic pregnancy, or eccysis, is a complication of pregnancy in which the embryo implants outside...⁴⁴ more...

ectopic pregnancy 30 23 43 pregnancy ectopic 32

Diseases related to ectopic pregnancy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 460)

id	Related Disease	Score	Top Affiliating Genes
1	creatine phosphokinase	30.4	PIK3C2A, CHKB, AFP, MYH11
2	teratoma	28.8	LIF, CGA, CGB, CGB5, CGB7, CSF1
3	blindness	25.2	PIK3C2A, CNR1, VEGFA, LIF, CHKB, CGA
4	choriocarcinoma	24.6	LNPEP, LIF, PAPPA, CGA, CGB, CGB5
5	leukemia	19.5	PIK3C2A, CNR1, SFRP4, BYSL, VEGFA, VCAM1
6	ovarian cancer	19.0	VEGFA, VCAM1, LNPEP, BMP6, LIF, PAEP
7	mixed ductal-endocrine carcinoma	13.8	CGB, CGB5, CGB7
8	placental site trophoblastic tumor	13.8	CGA, CGB, CGB5
9	gestational trophoblastic tumor	13.8	CGA, CGB, CGB5
10	trophoblastic neoplasm	13.7	LNPEP, CGA, CGB5
11	epithelioid trophoblastic tumor	13.7	LNPEP, CGA, CGB5
12	triploidy	13.7	PAPPA, CGA, CGB
13	habitual abortion	13.7	CGB, CGB5
14	ulcerative stomatitis	13.7	CGB5, CGB7
15	extragonadal germ cell tumor	13.7	CGB, CGB5, AFP
16	mature teratoma	13.7	CGA, CGB, AFP
17	ovarian mixed germ cell neoplasm	13.7	CGA, AFP
18	cutis marmorata telangiectatica congenita	13.7	CGA, AFP
19	polyembryoma	13.7	CGA, AFP
20	sacrococcygeal teratoma	13.6	CGA, CGB7, AFP
21	endodermal sinus tumor	13.6	CGB, CGB5, AFP
22	anencephaly	13.6	CGA, CGB5, AFP
23	tricuspid valve insufficiency	13.6	PAPPA, CGB
24	dysgerminoma	13.6	CGA, CGB, CGB5, AFP
25	nonseminomatous germ cell tumor	13.6	CGA, CGB, CGB5, CGB7, AFP
26	cryptococcosis	13.6	CGB, CGB5, CGB7, CD40LG
27	turner syndrome	13.6	PAEP, PAPPA, CGA, CGB
28	gestational trophoblastic neoplasm	13.6	CGA, CGB5, AFP
29	germinoma	13.6	CGA, CGB, CGB5, CGB7, AFP
30	neural tube defect	13.6	CGA, CGB, CGB5, CGB7, AFP
31	malignant germ cell tumor	13.5	CGB5, AFP
32	malignant sertoli cell tumor	13.5	CGB5, AFP
33	micropenis	13.5	CGA, CGB5, GNRH1
34	gonadotropin deficiency	13.5	CGA, GNRH1, PROKR2
35	gynecomastia	13.5	CGA, CGB, CGB5, GNRH1
36	ovarian cyst	13.5	PAEP, CGA, CGB5, GNRH1
37	leydig cell adenoma	13.5	CGA, GNRH1
38	hyperprolactinemia	13.5	CGA, CGB, CGB5, GNRH1
39	acute interstitial pneumonia	13.5	PIK3C2A, SCGB1A1, MMP7
40	delayed puberty	13.5	CGA, CGB5, GNRH1
41	fragile x-associated primary ovarian insufficiency	13.4	CGA, CGB5, GNRH1
42	congenital toxoplasmosis	13.4	CD79A, CD40LG
43	y chromosome infertility	13.4	CGA, CGB5, GNRH1
44	kallmann syndrome	13.4	CGA, CGB5, GNRH1, PROKR2
45	hypogonadotropism	13.4	CGA, CGB5, GNRH1, PROKR2
46	aorta atresia	13.4	PAPPA, CGA, GNRH1
47	klinefelter's syndrome	13.4	CGA, CGB, INHBA, GNRH1, PROKR2
48	cryptorchidism	13.3	CGA, CGB5, GNRH1, HOXA10, PROKR2
49	calciphylaxis	13.3	PIK3C2A, CD79A, CD40LG
50	familial male-limited precocious puberty	13.3	CGA, CGB5, GNRH1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ectopic pregnancy:

²²

MGI Mouse Phenotypes related to ectopic pregnancy:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.5	EBAG9
2	respiratory system phenotype	MP:0005388	9.7	LIF, SCGB1A1, PGF, MYH11, SFRP4, CHRNA7
3	renal/urinary system phenotype	MP:0005367	9.4	SFRP4, DKK1, INHBA, HOXA11, MYH11, GNRH1
4	endocrine/exocrine gland phenotype	MP:0005379	9.0	GNRH1, HOXA10, TLR2, PROKR2, INHBB, CD40LG
5	immune system phenotype	MP:0005387	8.6	FLT1, INHBB, EBAG9, GNRH1, MMP7, CD79A
6	integument phenotype	MP:0010771	8.4	INHBB, GNRH1, CNR1, INHBA, LIF, PROKR1
7	skeleton phenotype	MP:0005390	8.1	VEGFA, HOXA10, HOXA11, CSF1, LIF, BMP6
8	digestive/alimentary phenotype	MP:0005381	7.5	SFRP4, VEGFA, LIF, MYH11, INHBB, TLR2
9	behavior/neurological phenotype	MP:0005386	7.4	FLT1, CHKB, CHRNA7, LIF, LNPEP, CNR1
10	nervous system phenotype	MP:0003631	7.2	TLR2, TIMP2, DKK1, CSF1, PROKR2, HOXA10
11	growth/size phenotype	MP:0005378	7.0	PAPPA, MYH11, PROKR2, HOXA10, GNRH1, IL2RA
12	muscle phenotype	MP:0005369	6.9	ADAM12, CSF1, TLR2, NOS2, INHBB, INHBA
13	vision/eye phenotype	MP:0005391	6.9	VEGFA, LIF, MMP7, FLT1, INHBA, SP1
14	reproductive system phenotype	MP:0005389	6.5	GNRH1, INHBB, INHBA, VEGFA, FLT1, CGA
15	cardiovascular system phenotype	MP:0005385	6.2	TLR2, VEGFA, PROKR1, LIF, NOS2, VCAM1
16	mortality/aging	MP:0010768	4.5	TRO, SCGB1A1, INHBA, MYH11, AFP, VEGFA
17	homeostasis/metabolism phenotype	MP:0005376	3.8	DKK1, LIF, LNPEP, VCAM1, VEGFA, SFRP4

Articles related to ectopic pregnancy:

(show top 50)    (show all 179)

id	Title	Authors	Year	Affiliating Genes
1	Are early human chorionic gonadotropin levels after m ethotrexate therapy a predictor of response in ectopic pregnancy? (20510964)	Nguyen Q.... Silva C.	2010	CGB
2	Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy. (19046581)	Wang Y.... Tong J.	2010	CGA
3	Methotrexate treatment for ectopic pregnancy at the K K Women's and Children's Hospital, Singapore. (19960159)	Thia E.W.... Siow A.	2009	CGA
4	Role of activins and inducible nitric oxide in the pa thogenesis of ectopic pregnancy in patients with or without Chlamydia trachomat is infection. (19692623)	Refaat B.... Ledger W.	2009	NOS2, INHBA
5	Conservative management of tubal ectopic pregnancy. (19299204)	van Mello N.M.... Hajenius P.J.	2009	CGA
6	Analysis of metallothionein, RCAS1 immunoreactivity regarding immune cell concentration in the endometrium and tubal mucosa in ectopic pregnancy during the course of tubal rupture. (17717421)	Wicherek L.... Lazar A.	2008	EBAG9
7	Current evidence on surgery, systemic methotrexate an d expectant management in the treatment of tubal ectopic pregnancy: a systemati c review and meta-analysis. (18522946)	Mol F.... Hajenius P.J.	2008	CGA
8	Interstitial pregnancy: a rare type of ectopic pregnancy (18491819)	Timmerman E.... Hajenius P.J.	2008	CGB5
9	Concurrent interstitial ectopic pregnancy and appendi citis: a case report. (18567288)	Biggs R.L.... O'Boyle J.D.	2008	CGB
10	Single serum activin a testing to predict ectopic pregnancy. (17341564)	Florio P.... Petraglia F.	2007	CGB5
11	Suspected ectopic pregnancy. (16449130)	Seeber B.E.... Barnhart K.T.	2006	CGA
12	Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. (16389014)	Katsikis I.... Panidis D.	2006	PIK3C2A
13	Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. (15840789)	Bixby S.... Kuligowska E.	2005	CGB
14	Evaluation of the relationship between endometrial thickness and failure of single-dose methotrexate in ectopic pregnancy. (16001188)	Takacs P.... Verma U.	2005	CGB
15	Risk factors associated with the rupture of tubal ectopic pregnancy. (16141721)	Latchaw G.... Burzawa J.	2005	CGB
16	Characterizing ectopic pregnancies that rupture despi te treatment with methotrexate. (15533363)	Dudley P.S.... Buster J.E.	2004	CGA
17	Ectopic pregnancy: a review. (15322388)	Dialani V.... Levine D.	2004	CGB7
18	Risk factors for persistent trophoblastic activity after surgery for ectopic pregnancy. (15059161)	Nathorst-BAPAPs J.... Rafik Hamad R.	2004	CGA
19	Conservative treatment of ectopic pregnancy in a 27 years old patient with stage-Ia ovarian cancer after conservative surgical treatment and chemotherapy (15738608)	Malinowski A.... Ciesielski A.	2004	CGB5
20	Serum concentrations of interleukin-2R (IL-2R), IL-6, IL-8, and tumor necrosis factor alpha in patients with ectopic pregnancy. (12749440)	Soriano D.... Darai E.	2003	IL2RA
21	Management of non-surgical treatment of ectopic pregnancy (14699320)	Gervaise A.	2003	CGA
22	Non-invasive management of patients with suspected ectopic pregnancy: a survey among Dutch gynaecologists. (11267725)	Engelsbel S.... Bossuyt P.M.	2001	CGA
23	Anticardiolipin antibodies in ectopic pregnancies. (11604194)	Jacob-Meisel M.... Meisel P.	2001	CD40LG, CD79A
24	Low-resistance endometrial arterial flow in the exclusion of ectopic pregnancy revisited. (11316311)	Wherry K.L.... Reed S.	2001	CGB
25	Postoperative day 3 serum human chorionic gonadotropin decline as a predictor of persistent ectopic pregnancy after linear salpingotomy. (11788181)	Poppe W.A.... Vandenbussche N.	2001	CGB5
26	Diagnosing suspected ectopic pregnancy. Patients with falling concentrations of beta human chorionic gonadotrophin should be seen re gularly. (11282878)	Irvine L.M.	2001	CGB7
27	Early diagnosis of ectopic pregnancy. Does use of a s trict algorithm decrease the incidence of tubal rupture? (11209628)	Mertz H.L.... Yalcinkaya T.M.	2001	CGA
28	Differentiating tubal abortion from viable ectopic pregnancy with serum CA-125 and beta-human chorionic gonadotropin determinations. (10689006)	Predanic M.	2000	CGB
29	Early diagnosis of ectopic pregnancy: can we do it accurately using a biochemical profile? (10883946)	Spitzer M.... Benjamin F.	2000	PIK3C2A, CGB
30	Serum levels of smooth muscle heavy-chain myosin in patients with ectopic pregnancy. (10918100)	Birkhahn R.H.... Bove J.	2000	MYH11
31	Rate of change of serial beta-human chorionic gonadotropin values as a predictor of ectopic pregnancy in patients with indeterminate transvaginal ultrasound findings. (10577398)	Dart R.G.... Dart L.M.	1999	CGB, CGB5
32	Utility of a single beta HCG measurement to evaluate for absence of ectopic pregnancy. (10338231)	Marill K.A.... Nelson B.K.	1999	CGB5
33	A study of risk factors for ruptured tubal ectopic pregnancy. (9611704)	Falcone T.... Attaran M.	1998	CGA
34	Diagnosis of ectopic pregnancy--why we need a protocol. (9407760)	Koh G.H.... Yeo G.S.	1997	CGB5
35	Transvaginal sonography and serum hCG in monitoring of presumed ectopic pregnancies selected for expectant management. (7614131)	Cacciatore B.... YlAPstalo P.	1995	CGB5
36	Suspected ectopic pregnancy: expectant management in patients with negative sonographic findings and low serum hCG concentrations. (9363257)	Hajenius P.J.... Lammes F.B.	1995	CGB5
37	Measurement of creatine kinase activity and diagnosis of ectopic pregnancy. (7794849)	Duncan W.C.... Illingworth P.J.	1995	CGA
38	Suspected ectopic pregnancy. What to do when human chorionic gonadotropin levels are below the discriminatory zone. (7473443)	Ankum W.M.... Lammes F.B.	1995	CGB5
39	Chronic ectopic pregnancy after clinically successful methotrexate treatment of ectopic pregnancy. (8745091)	Dunn R.C.... Taskin O.	1995	CGB, CGB5
40	Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. (8567799)	Corsan G.H.... Kemmann E.	1995	CGA, CGB7
41	Laparoscopic prostaglandin injection in ectopic pregnancy: success rates according to endocrine activity. (7851573)	Paulsson G.... Lindblom B.	1995	CGA
42	Prediction of persistent ectopic pregnancy after laparoscopic salpingostomy. (7936515)	HagstrAPm H.G.... Lindblom B.	1994	CGA
43	Uncommon location of persistent ectopic pregnancy following laparoscopic surgery. (9205453)	Alge A.A.... Marth C.	1994	CGA
44	Intrauterine pregnancy after conservative treatment of ectopic pregnancy with contralateral removal of the adnexa (7926577)	Alge A.... Anderl P.	1994	CGA
45	Gonadotropin-producing benign cystic teratoma simulating a ruptured ectopic pregnancy. (7514671)	Pothula V.... Godfrey H.	1994	CGB
46	Accuracy of transvaginal ultrasound and serum hCG in the diagnosis of ectopic pregnancy. (12796988)	Gabrielli S.... Bovicelli L.	1992	CGA
47	Conservative treatment of ectopic pregnancy and its e ffect on corpus luteum activity. (1377160)	Shulman A.... Bahary C.	1992	CGB
48	Serial monitoring of human chorionic gonadotropin and free beta subunit secretion in ectopic pregnancy. (1790603)	Letterie G.S.... Hay D.L.	1991	CGB5
49	Diagnosis of ectopic pregnancy by the rate of increase of choriogonadotropin in serum: diagnostic criteria compared. (2253352)	Emancipator K.... Burke M.D.	1990	CGA
50	Laparoscopy and minilaparotomy as operative management of ectopic pregnancy. (2148969)	Letterie G.S.... Miyazawa K.	1990	CGB5

Genes related to ectopic pregnancy according to GeneCards:

(show all 49)

id	Symbol	Description	Score	GeneCards Section Context
1	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
2	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
3	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
4	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
5	TROAP	trophinin associated protein (tastin)	11.0	Publications
6	HOXA11	homeobox A11	11.0	Publications
7	PROK1	prokineticin 1	11.0	Publications
8	PROKR1	prokineticin receptor 1	11.0	Publications
9	TRO	trophinin	11.0	Publications
10	BYSL	bystin-like	11.0	Publications
11	CRISP3	cysteine-rich secretory protein 3	11.0	Publications
12	HOXA10	homeobox A10	11.0	Publications
13	PROKR2	prokineticin receptor 2	11.0	Publications
14	SFRP4	secreted frizzled-related protein 4	11.0	Publications
15	EBAG9	estrogen receptor binding site associated, antigen, 9	11.0	Publications
16	INHBB	inhibin, beta B	11.0	Publications
17	SCARA5	scavenger receptor class A, member 5 (putative)	11.0	Publications
18	INHBA	inhibin, beta A	11.0	Publications
19	DKK1	dickkopf 1 homolog (Xenopus laevis)	11.0	Publications
20	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
21	PAEP	progestagen-associated endometrial protein	11.0	Publications
22	LIF	leukemia inhibitory factor	11.0	Publications
23	LNPEP	leucyl/cystinyl aminopeptidase	11.0	Publications
24	PGF	placental growth factor	11.0	Publications
25	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
26	CHKB	choline kinase beta	11.0	Publications
27	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	11.0	Publications
28	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
29	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
30	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
31	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
32	CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	11.0	Publications
33	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
34	SP1	Sp1 transcription factor	11.0	Publications
35	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
36	TLR2	toll-like receptor 2	11.0	Publications
37	BMP6	bone morphogenetic protein 6	11.0	Publications
38	AFP	alpha-fetoprotein	11.0	Publications
39	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
40	CD40LG	CD40 ligand	11.0	Publications
41	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
42	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
43	ADAM12	ADAM metallopeptidase domain 12	11.0	Publications
44	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
45	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
46	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
47	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
48	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
49	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to ectopic pregnancy according to GeneDecks:

(show top 50)    (show all 51)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.7	PGF
2	Breast Cancer Regulation by Stathmin136	10.6	PROK1
3	Selected targets of Oct-3/410	10.3	DKK1, INHBB, CGB7, CGB
4	G alpha (q) signalling events38	9.8	PROKR1, PROK1, GNRH1, PROKR2
5	Inhibition of Matrix Metalloproteinases36	9.7	MMP7, MMP1, TIMP2, ADAM12
6	Glioma Invasiveness36	9.5	GNRH1, PROK1, PGF, BMP6
7	Akt Signaling36	9.5	PROK1, IL2RA, LIF, PGF, CSF1
8	Activation of Matrix Metalloproteinases38	9.4	TIMP2, MMP1, MMP7
9	14-3-3 Induced Intracellular Signaling36	9.4	FLT1, PROK1, PGF, GNRH1
10	Molecular Mechanisms of Cancer36	9.4	BMP6, LIF, GNRH1, TIMP2
11	PPAR Pathway36	9.3	IL2RA, PROK1, PGF, TIMP2, FLT1
12	JNK Pathway36	9.3	FLT1, IL2RA, PGF, BMP6
13	Paxillin Interactions36	9.2	PGF, TIMP2, PROK1, GNRH1, FLT1
14	Telomerase Components in Cell Signaling36	9.2	TIMP2, BMP6, FLT1, GNRH1, PROK1, PGF
15	CREB Pathway36	9.2	GNRH1, PROK1, BMP6, IL2RA, PGF
16	Nanog in Mammalian ESC Pluripotency36	9.1	TIMP2, GNRH1, FLT1, PGF, BMP6, PROK1
17	Ras Pathway36	9.0	GNRH1, FLT1, TIMP2, PROK1, PGF
18	eIF2 Pathway36	9.0	TIMP2, BMP6, IL2RA, GNRH1, PGF, PROK1
19	PTEN Pathway36	9.0	GNRH1, PGF, PROK1, FLT1, IL2RA
20	NF-KappaB (p50-p65) Pathway36	9.0	PGF, PROK1, TIMP2, TLR2, GNRH1, FLT1
21	NF-KappaB Family Pathway36	8.9	FLT1, GNRH1, PROK1, TIMP2, BMP6, PGF
22	eNOS Signaling36	8.9	GNRH1, BMP6, CHRNA7, TIMP2, FLT1, PGF
23	Estrogen Pathway36	8.9	BMP6, FLT1, PROK1, GNRH1, SP1, TIMP2
24	IP3 Pathway36	8.8	TIMP2, FLT1, BMP6, CD79A, GNRH1, PROK1
25	Rheumatoid arthritis20	8.8	PGF, TLR2, FLT1, MMP1, VEGFA, CSF1
26	NFAT in Immune Response36	8.8	GNRH1, TIMP2, PROK1, PGF, BMP6, CD79A
27	Intracellular Calcium Signaling36	8.8	FLT1, PGF, PROK1, TIMP2, GNRH1, CHRNA7
28	Pancreatic Adenocarcinoma36	8.7	FLT1, MMP7, MMP1, PGF, PROK1, TIMP2
29	ERK Signaling36	8.7	GNRH1, PROK1, PGF, TIMP2, FLT1, BMP6
30	Tec Kinases Signaling36	8.6	TLR2, PROK1, TIMP2, PGF, IL2RA, GNRH1
31	Apoptotic Pathways in Synovial Fibroblasts36	8.6	IL2RA, GNRH1, TIMP2, PROK1, PGF, FLT1
32	p53 Mediated Apoptosis36	8.6	TIMP2, PGF, GNRH1, PROK1, IL2RA, FLT1
33	Mitochondrial Apoptosis36	8.6	BMP6, FLT1, IL2RA, GNRH1, TIMP2, PROK1
34	DHA Signaling36	8.6	PGF, PROK1, BMP6, FLT1, IL2RA, GNRH1
35	Cellular Apoptosis Pathway36	8.6	BMP6, FLT1, IL2RA, PROK1, GNRH1, TIMP2
36	Nuclear Receptor Activation by Vitamin-A36	8.6	GNRH1, PGF, BMP6, PROK1, FLT1, IL2RA
37	Rac1 Pathway36	8.5	PGF, BMP6, FLT1, IL2RA, TIMP2, PROK1
38	p70S6K Signaling36	8.5	PGF, PROK1, BMP6, FLT1, IL2RA, GNRH1
39	Activation of PKC through GPCR36	8.5	IL2RA, GNRH1, TIMP2, PGF, BMP6, FLT1
40	TGF-Beta Pathway36	8.5	PROK1, PGF, TIMP2, FLT1, GNRH1, BMP6
41	Rho Family GTPases36	8.5	LIF, BMP6, FLT1, GNRH1, PROK1, CSF1
42	ERK5 Signaling36	8.5	PGF, LIF, FLT1, IL2RA, GNRH1, TIMP2
43	MAPK Family Pathway36	8.4	GNRH1, PROK1, PGF, IL2RA, TIMP2, FLT1
44	Phospholipase-C Pathway36	8.3	PROK1, FLT1, CD79A, GNRH1, TIMP2, IL2RA
45	Renin-Angiotensin Pathway36	8.3	VCAM1, IL2RA, GNRH1, TIMP2, PROK1, PGF
46	JAK-STAT Pathway36	8.3	GNRH1, PGF, FLT1, IL2RA, PROK1, TIMP2
47	Cytokine-cytokine receptor interaction20	8.2	INHBA, CD40LG, FLT1, INHBB, IL2RA, CSF1
48	PAK Pathway36	7.9	MYH11, CSF1, PROK1, TIMP2, GNRH1, IL2RA
49	Antioxidant Action of Vitamin-C36	7.9	FLT1, MYH11, BMP6, LIF, IL2RA, GNRH1
50	p38 Signaling36	7.8	PGF, CSF1, PROK1, TIMP2, SP1, GNRH1

Compounds related to ectopic pregnancy according to GeneDecks:

(show top 50)    (show all 197)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.4	PGF, CGB
2	oestriol32	10.1	AFP, CGB5, CGA, CGB, PAPPA, CGB7
3	gnrh32	9.9	CGB5, CGB7, SP1, CGB
4	clomiphene citrate32	9.4	PAEP, CGA, CGB, CGB5, CD40LG, GNRH1
5	estradiol32 9 18 9	12.4	CHKB, PAEP, AFP, TIMP2, HOXA10, CGB7
6	pge232	9.3	VCAM1, LNPEP, LIF, PAEP, CHRNA7, CGA
7	bleomycin32 9 9	11.2	IL2RA, CGB7, HSPD1, AFP, CGB
8	ascorbic acid32 18	10.2	CGB5, LIF, CHKB, CGA, CD40LG, IL2RA
9	h2o232	8.8	CSF1, SP1, HSPD1, IL2RA, LIF, CGA
10	progestin32	8.6	CGB5, GNRH1, SP1, CSF1, CGA, VEGFA
11	aspartate32	8.6	CNR1, GNRH1, CD40LG, CGA, CHRNA7, CHKB
12	heparin32 9 18 9	11.4	TIMP2, PIK3C2A, LIF, PAPPA, CHKB, CGA
13	fibrinogen32	8.4	VCAM1, HSPD1, MMP7, CD40LG, CGB5, CD79A
14	cysteine32	8.3	CHRNA7, PAPPA, SP1, CHKB, CGB, HLA-G
15	epinephrine32 9 18 9	11.1	AFP, CSF1, BMP6, CGB5, CD79A, MMP1
16	methotrexate32 34 42 9 9	12.0	AFP, TIMP2, HLA-G, CGB7, PIK3C2A, IL2RA
17	atorvastatin32 34 9 18 9	11.9	PIK3C2A, VCAM1, BMP6, CHKB, PGF, IL2RA
18	mifepristone32 42 9 9	10.9	VEGFA, LIF, PAEP, CGA, CGB, CGB5
19	aspirin32 34 18	9.8	MMP1, CGB5, CSF1, CNR1, BMP6, CHKB
20	ly29400232	7.8	PIK3C2A, VEGFA, SP1, NOS2, TIMP2, MYH11
21	polysaccharide32	7.8	IL2RA, CD79A, CGB5, CHKB, PAEP, LIF
22	ribonucleic acid32	7.7	CGA, CGB5, MMP1, MMP7, FLT1, GNRH1
23	estrogen32	7.7	MYH11, AFP, TIMP2, NOS2, HOXA10, GNRH1
24	matrigel32	7.6	TIMP2, MMP7, VEGFA, MMP1, CGB, LIF
25	norepinephrine32 9 18 9	10.4	LIF, BMP6, VCAM1, CNR1, PIK3C2A, IL2RA
26	steroid32	7.4	AFP, SCGB1A1, PROK1, TIMP2, SP1, HOXA10
27	oxygen32 18	8.3	SCGB1A1, CHRNA7, CHKB, FLT1, CGB5, HSPD1
28	prostacyclin32	7.3	CSF1, PIK3C2A, SP1, FLT1, CGA, BMP6
29	progesterone32 42 9 18 9	11.2	CGB7, HOXA11, DKK1, PROK1, CSF1, AFP
30	cyclosporin a32 42	8.2	PIK3C2A, BMP6, LIF, CGA, CD40LG, IL2RA
31	paclitaxel32 34 9 9	10.0	LNPEP, SP1, IL2RA, AFP, FLT1, MMP1
32	indomethacin32 9 9	9.0	NOS2, HSPD1, IL2RA, CD40LG, CNR1, CD79A
33	cycloheximide32	6.9	BMP6, LIF, CGA, CGB5, HSPD1, HOXA10
34	lactate32	6.8	CD40LG, MMP1, GNRH1, HSPD1, HLA-G, TIMP2
35	actinomycin d32	6.8	NOS2, VEGFA, PAPPA, CSF1, TLR2, SP1
36	doxorubicin32 34 9 9	9.8	BMP6, VEGFA, PIK3C2A, CGA, AFP, SP1
37	creatinine32	6.6	BMP6, AFP, PGF, CSF1, TIMP2, PAPPA
38	acetylcholine32 9 18 9	9.6	CSF1, NOS2, SP1, CHRNA7, LIF, CNR1
39	cisplatin32 34 9 9	9.6	PIK3C2A, LIF, AFP, HSPD1, GNRH1, CGB
40	testosterone32 9 18 9	9.5	IL2RA, INHBA, MMP1, CSF1, HOXA10, CD79A
41	alanine32	6.4	TIMP2, TLR2, SP1, HOXA11, HSPD1, GNRH1
42	n acetylcysteine32	6.4	VEGFA, MMP1, VCAM1, CHKB, IL2RA, NOS2
43	retinoic acid32 42 18	8.4	MYH11, AFP, CSF1, TIMP2, TLR2, SP1
44	phosphatidylinositol32	6.3	BMP6, IL2RA, FLT1, MYH11, PGF, LIF
45	vegf32	6.3	CGB5, CGB, CGA, CHKB, PAPPA, PAEP
46	genistein32 9 18 9	9.2	CSF1, LIF, TIMP2, NOS2, VEGFA, VCAM1
47	arginine32	6.0	LIF, GNRH1, CSF1, CD40LG, TLR2, NOS2
48	paraffin32	6.0	TIMP2, CSF1, PGF, AFP, MYH11, HSPD1
49	tyrosine32	5.5	IL2RA, BYSL, FLT1, VEGFA, HSPD1, HOXA10
50	dexamethasone32 42 34 9 9	8.8	VEGFA, VCAM1, BMP6, LIF, HLA-G, PAPPA

Cellular components related to ectopic pregnancy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	8.5	TIMP2, SFRP4, VEGFA, VCAM1, SCARA5, HSPD1
2	extracellular region	GO:005576	6.9	MMP1, ADAM12, PGF, VEGFA, LNPEP, PAEP
3	extracellular space	GO:005615	6.5	AFP, SFRP4, VEGFA, VCAM1, BMP6, LIF
4	plasma membrane	GO:005886	6.1	ADAM12, EBAG9, CSF1, PROKR2, PROKR1, DKK1

Biological processes related to ectopic pregnancy according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of ovulation	GO:060279	10.1	INHBA, INHBB
2	embryo implantation	GO:007566	10.1	TRO, LIF, SCGB1A1
3	B cell proliferation	GO:042100	9.7	CD40LG, CD79A, HSPD1
4	positive regulation of interleukin-12 production	GO:032735	9.7	CD40LG, HSPD1, HLA-G, TLR2
5	cell-cell signaling	GO:007267	9.4	LNPEP, CGB, INHBA, GNRH1, PGF, CGA
6	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.0	VEGFA, FLT1, PGF
7	female pregnancy	GO:007565	9.0	BYSL, LNPEP, PAPPA, SCGB1A1, FLT1, GNRH1
8	positive regulation of cell proliferation	GO:008284	8.6	VEGFA, LIF, CHRNA7, CGA, PROK1, CSF1
9	response to hypoxia	GO:001666	8.2	PGF, CHRNA7, VEGFA, VCAM1, FLT1, NOS2

Molecular functions related to ectopic pregnancy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	9.3	INHBB, CGA, CGB, INHBA, GNRH1
2	growth factor activity	GO:008083	8.5	LIF, BMP6, INHBA, INHBB, DKK1, PROK1
3	cytokine activity	GO:005125	8.5	VEGFA, LIF, BMP6, CD40LG, INHBA, CSF1
4	protein homodimerization activity	GO:042803	7.8	CSF1, NOS2, SP1, HLA-G, INHBB, CHRNA7