MCID: ECT026
MIFTS: 45

Ectopic Pregnancy malady

Rare diseases category
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Summaries for Ectopic Pregnancy

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 The uterus, or womb, is an important female reproductive organ. it is the place where a baby grows when a woman is pregnant. if you have an ectopic pregnancy, the fertilized egg grows in an abnormal place, outside the uterus, usually in the fallopian tubes. the result is usually a miscarriage. ectopic pregnancy can be a medical emergency if it ruptures. signs of ectopic pregnancy include abdominal pain shoulder pain vaginal bleeding feeling dizzy or faint get medical care right away if you have these signs. doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. many women who have had ectopic pregnancies go on to have healthy pregnancies later. dept. of health and human services office on women's health

MalaCards: Ectopic Pregnancy, also known as pregnancy ectopic, is related to choriocarcinoma and infertility. An important gene associated with Ectopic Pregnancy is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Selected targets of Oct 3 4 and Peptide hormone metabolism. The drug mifepristone and the compounds oestriol and ctp have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and uterus, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:65 An ectopic pregnancy, or eccysis, is a complication of pregnancy in which the embryo implants outside... more...

Aliases & Classifications for Ectopic Pregnancy

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Sources:
43NIH Rare Diseases, 34MedlinePlus, 62UMLS, 45Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

ectopic pregnancy 43 34 62
pregnancy ectopic 45


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ICD1025 O00

Related Diseases for Ectopic Pregnancy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ectopic Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma30.7CGB, CGA
2infertility30.6CGA, CGB, PROK1, HOXA10
3endometriosis30.5HOXA10, CGA
4teratoma30.5CGB, CGA
5placental site trophoblastic tumor30.3CGB, CGA
6hyperprolactinemia30.0CGA, CGB
7gestational trophoblastic neoplasm30.0CGB, CGA
8polycystic ovary syndrome30.0CGA, PROK1
9cervicitis10.6
10salpingitis10.5
11pelvic inflammatory disease10.5
12ovarian cyst10.3
13ovarian hyperstimulation syndrome10.3
14gestational choriocarcinoma10.3
15endotheliitis10.3
16cystic teratoma10.3
17leukemia10.3
18appendicitis10.2
19tuberculous salpingitis10.2
20myoma10.1
21acromegaly10.1
22adenomatoid tumor10.1
23ovarian endometriosis10.1
24salpingitis isthmica nodosa10.1
25corpus luteum cyst10.1
26sarcoma10.1
27schistosomiasis10.1
28tuberculosis10.1
29vaginitis10.1
30blindness10.1
31varicocele10.1CGA
32germinoma10.1CGA, CGB
33gestational trophoblastic tumor10.1CGA, CGB
34turner syndrome10.1CGB, CGA
35neural tube defects10.1CGA, CGB
36klinefelter's syndrome10.1CGA, CGB
37testicular cancer10.1CGB, CGA
38prolactinoma10.1CGB, CGA
39hyperthyroidism10.0CGA, CGB
40seminoma10.0CGB, CGA
41embryonal cancer10.0CGB, CGA
42cryptorchidism10.0CGA, HOXA10
43pre-eclampsia10.0PROK1, CGA, CGB
44down syndrome10.0CGA, CGB
45pregnancy loss10.0HOXA10, CGB, CGA
46cystadenoma10.0
47primary ciliary dyskinesia10.0
48methemoglobinemia10.0
49nephrosclerosis10.0
50spindle cell carcinoma10.0

Graphical network of the top 20 diseases related to Ectopic Pregnancy:



Diseases related to ectopic pregnancy

Symptoms for Ectopic Pregnancy

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Drugs & Therapeutics for Ectopic Pregnancy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Ectopic Pregnancy

Search NIH Clinical Center for Ectopic Pregnancy

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Ectopic Pregnancy

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Anatomical Context for Ectopic Pregnancy

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33MalaCards
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MalaCards organs/tissues related to Ectopic Pregnancy:

33
Ovary, Cervix, Uterus, Testes, Endothelial, Liver, Placenta, Smooth muscle, Myeloid, Nk cells, Kidney

Animal Models for Ectopic Pregnancy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ectopic Pregnancy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3CGA, INHBB, HOXA10, HOXA11
2MP:00053897.6CGA, PROKR1, INHBB, HOXA10, HOXA11

Publications for Ectopic Pregnancy

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52PubMed
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Articles related to Ectopic Pregnancy:

(show top 50)    (show all 702)
idTitleAuthorsYear
1
Is laparoscopic surgery safe in patients with an elevated shock index due to ruptured ectopic pregnancy? (24283178)
2013
2
A case of Hickam's dictum: concurrent appendicitis and ectopic pregnancy. (23993940)
2013
3
Can ratio of blood/curettage material HCG be used as a reliable method for differentiating miscarriage and ectopic pregnancy? (24353723)
2013
4
An appraisal of the management of ectopic pregnancy in a nigerian tertiary hospital. (23919183)
2013
5
Ectopic pregnancy prediction in women with a pregnancy of unknown location: data beyond 48 h are necessary. (24352889)
2013
6
Compliance with follow-up in an inner-city population treated with intramuscular methotrexate for suspected ectopic pregnancy. (23276602)
2013
7
Alteration of peripheral blood cells in tubal ectopic pregnancy. (23700846)
2013
8
Hepatic ectopic pregnancy treated successfully by hepatectomy. (24342336)
2013
9
Is a standardized questionnaire useful for tubal rupture screening in patients with ectopic pregnancy? (22221975)
2012
10
Successful conservative management of ectopic pregnancy in caesarean section scar. (23266774)
2012
11
An unusual case of rudimentary uterine horn ectopic pregnancy. (22498858)
2012
12
Frozen-thawed embryo transfer isA associated with a significantly reduced incidence of ectopic pregnancy. (22925683)
2012
13
Recurrent ectopic pregnancy in a woman suffering from infertility due to male factor presented with heterotopic pregnancy. (22605872)
2012
14
Pheochromocytoma in ectopic pregnancy: a case report. (23444769)
2012
15
The Values of CA-125, Progesterone, A9-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy. (22496937)
2012
16
Conservative treatment of ectopic pregnancy in a sub-Saharan African setting. (21421884)
2011
17
Ectopic pregnancy after levonorgestrel emergency contraception. (21310292)
2011
18
Ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast. (21858178)
2011
19
Ectopic pregnancy: using the hCG ratio to select women for expectant or medical management. (21306315)
2011
20
Frequency of ectopic pregnancy in a medical centre, Kingdom of Saudi Arabia. (21465931)
2011
21
Development of a multiple marker test for ectopic pregnancy. (21343760)
2011
22
Abdominal Compartment Syndrome complicating massive hemorrhage from an unusual presentation of ruptured ectopic pregnancy. (21912014)
2011
23
Risk factors for ectopic pregnancy after in vitro fertilization treatment. (21846451)
2011
24
Laparoendoscopic single-site salpingectomy in isthmic and ampullary ectopic pregnancy: preliminary report and technique. (21354069)
2011
25
Histopathology indicates lymphatic spread of a pelvic retroperitoneal ectopic pregnancy removed by robot-assisted laparoscopy with temporary occlusion of the blood supply. (20334587)
2010
26
Salpingotomy or salpingectomy in tubal ectopic pregnancy: what do women prefer? (20884296)
2010
27
Association study of vascular endothelial growth factor and polymorphisms of its gene with ectopic pregnancy. (20015329)
2010
28
Emergency ultrasound diagnosis of ruptured ectopic pregnancy. (19919565)
2009
29
Chlamydia trachomatis infections and the risk of ectopic pregnancy in Khon Kaen women. (19751341)
2009
30
Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (19282327)
2009
31
Relevance of declines in serum human chorionic gonadotropin levels to the management of persistent ectopic pregnancy. (20149048)
2009
32
Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report. (18459557)
2008
33
Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy. (17418833)
2007
34
Risk factors for persistent trophoblastic activity after surgery for ectopic pregnancy. (15059161)
2004
35
Human chorionic gonadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy: a blinded study. (12749441)
2003
36
Case report: serial serum HCG measurements in a patient with an ectopic pregnancy: a case for caution. (10875883)
2000
37
HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies. (10825371)
2000
38
Vascular cell adhesion molecule-1 in normal, failed, and ectopic pregnancy. (10735600)
2000
39
Local application of methotrexate for ectopic pregnancy with a percutaneous puncturing technique. (9565137)
1998
40
Co-existing endometrial adenocarcinoma and tubal ectopic pregnancy: a case report. (9197189)
1997
41
Treatment of ectopic pregnancy by transvaginal ultrasonography-guided puncture and local application of methotrexate]. (7739852)
1995
42
Expectant management of suspected ectopic pregnancies even with rising beta-subunit human chorionic gonadotropin levels. A clinical prospective study. (7526807)
1994
43
Serum human chorionic gonadotropin dynamics during spontaneous resolution of ectopic pregnancy. (8150103)
1994
44
The hormonal profile in ectopic pregnancies. (7520962)
1993
45
Methotrexate for treatment of unruptured ectopic pregnancy. (1534728)
1992
46
Gestational choriocarcinoma in a tubal ectopic pregnancy. (1315103)
1992
47
Medicosurgical approach to diagnosis and treatment of ectopic pregnancy. (1813010)
1991
48
Pharmacokinetics of methotrexate and clinical response associated in the medical treatment of ectopic pregnancies]. (1754988)
1991
49
Isthmic ectopic pregnancy and salpingitis isthmica nodosa. (3666179)
1987
50
Herpes gestationis associated with ectopic pregnancy. (6752234)
1982

Variations for Ectopic Pregnancy

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Expression for genes affiliated with Ectopic Pregnancy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ectopic Pregnancy

Search GEO for disease gene expression data for Ectopic Pregnancy.

Pathways for genes affiliated with Ectopic Pregnancy

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50PathCards, 12EMD Millipore, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CGB, INHBB
2
Show member pathways
9.2CGA, CGB, INHBB
3
Show member pathways
9.2CGA, CGB, INHBB
4
Show member pathways
9.1PROK1, PROKR1, CGA
5
Show member pathways
8.6CGA, PROKR1, PROK1, INHBB

Compounds for genes affiliated with Ectopic Pregnancy

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45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Ectopic Pregnancy according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1oestriol4510.1CGA, CGB
2ctp4510.0CGA, CGB
3clomiphene citrate4510.0CGA, CGB
4ifosfamide45 1111.0CGA, CGB
5bleomycin45 1110.9CGA, CGB
6androstenedione45 2410.9CGB, CGA
7mifepristone45 29 61 1112.9CGA, CGB
8cyclophosphamide45 51 1111.8CGA, CGB
9thyroxine45 2410.7CGB, CGA
10gnrh459.5INHBB, CGB, CGA
11diethylstilbestrol45 29 1111.5CGA, HOXA10
12estradiol45 24 1111.2HOXA10, CGB, CGA
13vegf459.1PROK1, PROKR1, CGB, CGA
14alanine459.0CGA, CGB, HOXA11
15testosterone45 61 24 1112.0HOXA10, CGB, CGA
16steroid458.8CGA, PROK1, HOXA10
17progesterone45 29 61 24 1112.3CGA, CGB, PROK1, HOXA10, HOXA11

GO Terms for genes affiliated with Ectopic Pregnancy

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16Gene Ontology
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Cellular components related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7CGA, CGB, PROK1, INHBB

Biological processes related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.9CGA, CGB
2developmental growthGO:0485899.7CGA, HOXA11
3proximal/distal pattern formationGO:0099549.3HOXA10, HOXA11
4skeletal system developmentGO:0015019.2HOXA10, HOXA11
5embryonic limb morphogenesisGO:0303269.1HOXA11, HOXA10
6anterior/posterior pattern specificationGO:0099528.9HOXA10, HOXA11

Molecular functions related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.4PROK1, INHBB
2hormone activityGO:0051798.9CGA, CGB, INHBB

Products for genes affiliated with Ectopic Pregnancy

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Sources for Ectopic Pregnancy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet