MCID: ECT026
MIFTS: 50

Ectopic Pregnancy malady

Summaries for Ectopic Pregnancy

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 The uterus, or womb, is an important female reproductive organ. it is the place where a baby grows when a woman is pregnant. if you have an ectopic pregnancy, the fertilized egg grows in an abnormal place, outside the uterus, usually in the fallopian tubes. the result is usually a miscarriage. ectopic pregnancy can be a medical emergency if it ruptures. signs of ectopic pregnancy include abdominal pain shoulder pain vaginal bleeding feeling dizzy or faint get medical care right away if you have these signs. doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. many women who have had ectopic pregnancies go on to have healthy pregnancies later. dept. of health and human services office on women's health

MalaCards: Ectopic Pregnancy, also known as pregnancy ectopic, is related to infertility and teratoma. An important gene associated with Ectopic Pregnancy is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and Selected targets of Oct-3/4. The drug mifepristone and the compounds 11-ketotestosterone and mit1 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:64 An ectopic pregnancy, or eccysis, is a complication of pregnancy in which the embryo implants outside... more...

Aliases & Classifications for Ectopic Pregnancy

Sources:
43NIH Rare Diseases, 34MedlinePlus, 61UMLS, 45Novoseek, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

ectopic pregnancy 43 34 61
pregnancy ectopic 45


External Ids:

ICD1025 O00

Related Diseases for Ectopic Pregnancy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ectopic Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.6CGA, CGB, TRO, LIF, HOXA10, PAEP
2teratoma30.3CGB, CGB5, CGA, LIF, CGB7
3adenoma30.2CGA, PAEP, CGB7, CGB, INHBA, LIF
4placental site trophoblastic tumor30.1CGA, CGB, CGB5
5polycystic ovary syndrome29.9CGA, CGB5, PROK1
6gestational trophoblastic neoplasm29.9CGB5, PAEP, CGA, CGB, CGB7
7hyperprolactinemia29.9CGB, CGB5, CGA
8adenocarcinoma29.9PAEP, INHBA, LIF, CGB, CGB5, CRISP3
9trachoma10.4
10ovarian hyperstimulation syndrome10.3
11appendicitis10.2
12tuberculous salpingitis10.2
13fallopian tube endometriosis10.2
14pregnancy adenoma10.2
15corpus luteum cyst10.1
16myoma10.1
17cervix endometriosis10.1
18ovarian endometriosis10.1
19salpingitis isthmica nodosa10.1
20acromegaly10.1
21fallopian tube teratoma10.1
22adenomatoid tumor10.1
23tuberculosis10.1
24peritonitis10.0LIF
25obesity10.0LIF
26thyroiditis10.0CGA
27melanoma10.0CGB, CHKB
28leydig cell tumor10.0CGA, CGB5
29germinoma10.0CGB5, CGB, CGA
30multiple myeloma10.0DKK1
31leiomyoma10.0PAEP
32gestational trophoblastic tumor10.0CGB5, CGB, CGA
33dysgerminoma10.0CGA, CGB5
34hyperthyroidism10.0CGB, CGB5, CGA
35gynecomastia10.0CGB5, CGA
36seminoma10.0CGB, CGB5, CGB7, CGA
37varicocele10.0CGA
38klinefelter's syndrome10.0CGA, PROKR2, CGB
39ovarian cyst10.0PAEP, CGB5, CGA
40neural tube defects10.0CGB5, CGB7, CGA, CGB
41extragonadal germ cell tumor10.0CGB5
42pituitary adenoma10.0CGB7, CGA, LIF
43cryptorchidism10.0HOXA10, CGA, CGB5
44cryptococcosis10.0CGB, CGB5, CGB7
45ovarian cancer10.0CGB5, CGB, LIF, PAEP
46turner syndrome10.0PAEP, CGA, CGB
47teratocarcinoma10.0TRO, TROAP
48endometriosis10.0LIF, PAEP, HOXA10, CGA
49myeloma10.0LIF, DKK1
50choriocarcinoma10.0CGB5, CGB7, LIF, CGB, CGA

Graphical network of the top 20 diseases related to Ectopic Pregnancy:



Diseases related to ectopic pregnancy

Clinical Features for Ectopic Pregnancy

Drugs & Therapeutics for Ectopic Pregnancy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ectopic Pregnancy

Drug clinical trials:

Search ClinicalTrials for Ectopic Pregnancy

Search NIH Clinical Center for Ectopic Pregnancy

Search CenterWatch for Ectopic Pregnancy

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Ectopic Pregnancy

Anatomical Context for Ectopic Pregnancy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Ectopic Pregnancy:

33
Whole blood, Lymph node, Brain, Smooth muscle, Kidney, Liver, Thyroid, Breast, Ovary, Uterus, Placenta, Cervix, Myeloid, Nk cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal thyroid, Pancreatic islet, Pituitary, Uterus corpus

Animal Models for Ectopic Pregnancy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Ectopic Pregnancy

Sources:
51PubMed
See all sources

Articles related to Ectopic Pregnancy:

(show top 50)    (show all 714)
idTitleAuthorsYear
1
Diagnosis and management of ectopic pregnancy. (23826778)
2013
2
Association of anti-Chlamydia antibodies with ectopic pregnancy in Benin city, Nigeria: a case-control study. (24235946)
2013
3
Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison. (23081873)
2013
4
Intramural ectopic pregnancy: treatment using uterine artery embolization. (23465260)
2013
5
Does methotrexate administration for ectopic pregnancy after in vitro fertilization impact ovarian reserve or ovarian responsiveness? (24035728)
2013
6
Pitfalls in cervical ectopic pregnancy diagnosis by emergency medicine physicians using bedside ultrasonography: a case report. (24342865)
2013
7
Clinical course of ectopic pregnancy: A single-center experience. (23869156)
2013
8
The Values of CA-125, Progesterone, A9-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy. (22496937)
2012
9
Why does the fallopian tube fail in ectopic pregnancy? The role of activins, inducible nitric oxide synthase, and MUC1 in ectopic implantation. (22425195)
2012
10
Assessment of transvaginal hysterotomy combined with medication for cesarean scar ectopic pregnancy. (22935305)
2012
11
Ruptured ectopic pregnancy in caesarean section scar: a case report. (23198194)
2012
12
Fertility after tubal ectopic pregnancy: results of a population-based study. (22818285)
2012
13
Serum biomarkers for detecting ectopic pregnancy. (22510623)
2012
14
Frequency of ectopic pregnancy in a medical centre, Kingdom of Saudi Arabia. (21465931)
2011
15
Risk factors for ectopic pregnancy after in vitro fertilization treatment. (21846451)
2011
16
A new clinical sign in ruptured ectopic pregnancy. (22177516)
2011
17
Importance of timing of gestational exposure to methotrexate for its teratogenic effects when used in setting of misdiagnosis of ectopic pregnancy. (21733506)
2011
18
Primary ovarian choriocarcinoma presenting with acute abdomen mimicking an ectopic pregnancy. (21941968)
2011
19
Non-surgical management of ectopic pregnancy: appropriate risk management must be in place. (21153649)
2011
20
Ectopic pregnancy confirming the transperitoneal transport of gametes/embryos--a case report. (20568522)
2010
21
The efficacy of multiple-dose methotrexate treatment for unruptured tubal ectopic pregnancy and conversion rate to surgery: a study on 294 cases. (20137786)
2010
22
An alternative monitoring protocol for single-dose methotrexate therapy in ectopic pregnancy. (19962125)
2010
23
Case of chronic ectopic pregnancy diagnosed in which the complete shape of the fetus was visible by ultrasonography. (20492409)
2010
24
Laparoscopic management of ectopic pregnancy during a 9-year period. (20605142)
2010
25
Laparoscopic cornuotomy in the management of an advanced interstitial ectopic pregnancy: a case report. (19718563)
2010
26
Conservative laparoscopic management of a case of ruptured ovarian ectopic pregnancy by using a Harmonic scalpel. (20121515)
2010
27
Ectopic pregnancy in a uterine perforation site. (19576364)
2009
28
Ultrasound monitoring in patients undergoing in-vitro fertilization after methotrexate treatment for ectopic pregnancy. (19902469)
2009
29
Recurrent ectopic pregnancy in the ipsilateral oviduct after prior laparoscopic partial salpingectomy. (20045767)
2009
30
Cervical intramural ectopic pregnancy. (19560573)
2009
31
Primary extrauterine ovarian choriocarcinoma mistaken for ectopic pregnancy: sonographic imaging findings. (17954626)
2007
32
Serum biochemistry correlates with the size of tubal ectopic pregnancy on sonography. (17031874)
2006
33
Evaluation of the relationship between endometrial thickness and failure of single-dose methotrexate in ectopic pregnancy. (16001188)
2005
34
Ectopic pregnancy in a caesarean scar: a case report. (16524528)
2005
35
Ruptured ovarian cysts and bilateral ectopic pregnancy complicating a case of severe ovarian hyperstimulation syndrome. (15983688)
2005
36
Value of serum progesterone for ectopic pregnancy in therapeutic effect monitoring]. (12581973)
2003
37
Human chorionic gonadotropin patterns after a single dose of methotrexate for ectopic pregnancy. (11750970)
2002
38
Early diagnosis of ectopic pregnancy: can we do it accurately using a biochemical profile? (10883946)
2000
39
Adnexal ring sign and hemoperitoneum caused by hemorrhagic ovarian cyst: pitfall in the sonographic diagnosis of ectopic pregnancy. (10541109)
1999
40
Implementation of probabilistic decision rules improves the predictive values of algorithms in the diagnostic management of ectopic pregnancy. (10548636)
1999
41
Recurrent pregnancy-related upper airway obstruction caused by intratracheal ectopic thyroid tissue. (10524576)
1999
42
Preliminary results on the role of embryonic human chorionic gonadotrophin in corpus luteum rescue during early pregnancy and the relationship to abortion and ectopic pregnancy. (10469714)
1999
43
Local application of methotrexate for ectopic pregnancy with a percutaneous puncturing technique. (9565137)
1998
44
A study of ruptured tubal ectopic pregnancy. (9207811)
1997
45
Treatment of ectopic pregnancy by transvaginal ultrasonography-guided puncture and local application of methotrexate]. (7739852)
1995
46
Serum human chorionic gonadotropin dynamics during spontaneous resolution of ectopic pregnancy. (8150103)
1994
47
Rapid diagnosis of early ectopic pregnancy in an emergency gynaecology service--are measurements of progesterone, intact and free beta human chorionic gonadotrophin helpful? (7515072)
1994
48
Serum human chorionic gonadotropin: surveillance after radical and conservative management of ectopic pregnancy. (1683654)
1991
49
Diagnosis of ectopic pregnancy by the rate of increase of choriogonadotropin in serum: diagnostic criteria compared. (2253352)
1990
50
Recurrent ectopic pregnancy in the stump of a fallopian tube complicated by pyosalpinx; case report. (13490870)
1957

Genetic Variations for Ectopic Pregnancy

Expression for genes affiliated with Ectopic Pregnancy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ectopic Pregnancy

Search GEO for disease gene expression data for Ectopic Pregnancy.

Pathways for genes affiliated with Ectopic Pregnancy

Sources:
54Reactome, 12EMD Millipore
See all sources

Pathways related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CGB, CGA
210.2INHBB, DKK1, CGB, CGB7

Compounds for genes affiliated with Ectopic Pregnancy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Ectopic Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4510.7CGB5, CGA
2mit12910.7PROKR2, PROKR1
3pge24510.7PAEP
4prokineticin-2β2910.7PROKR1, PROKR2
5prokineticin-12910.7PROKR1, PROKR2
6prokineticin-22910.7PROKR2, PROKR1
7estrogen4510.7HOXA10, PAEP, CHKB
8onapristone45 2911.7CGA, LIF, PAEP
9oestradiol valerate4510.7PAEP, CGA
10buserelin45 29 1112.7PAEP, CGA, CGB5
11oestriol4510.7CGB, CGB7, CGB5, CGA
12organon4510.7CGA, CGB5
13ctp4510.7CGB5, CGB7, CGA, CGB
14ifosfamide45 1111.6CGA, CGB, CGB5
15clomiphene citrate4510.6PAEP, CGA, CGB, CGB5
16diethylstilbestrol45 29 1112.6HOXA10, CGB5, CGA
17bleomycin45 1111.6CGA, CGB5, CGB7, CGB
18percoll4510.6CRISP3, CGB5, CGA
19cycloheximide4510.6HOXA10, CGB5
20androstenedione45 2411.6CGB, CGB5, CGA, PAEP
21trilostane45 1111.6CGB5, CGA
22prostaglandin f2alpha4510.6CGA, CGB5, LIF
23thyroxine45 2411.6CGB7, CGA, CGB, CHKB
24progestin4510.6PAEP, CGA, LIF, CGB5
25phenylephrine45 29 11 2413.6LIF, CGB5, CGA
26methotrexate45 50 1112.6CGB, CHKB, CGA, CGB5, CGB7
27mifepristone45 60 29 1113.6CGB5, LIF, CGA, PAEP, CGB
28etoposide45 50 60 1113.6CGB7, CGB, CGB5
29estradiol benzoate4510.5CGB5, CGA
30prostaglandin4510.5LIF, HOXA10, PAEP, CGB5, CGA
31gnrh4510.5CGB7, CGA, INHBB, CGB, CGB5
32dbc-amp4510.5LIF, CGB5, CGA
3317-hydroxypregnenolone4510.5CGA, CGB5
34lactate4510.5CGB7, CGA, CHKB, LIF, CGB, CGB5
35creatinine4510.5CGA, SCGB1A1, CGB5, CHKB, CGB, LIF
36cisplatin45 50 60 1113.5LIF, CGB, CGA, CGB5, CGB7
37leuprolide45 60 29 1113.5CGA, CGB5
38ribonucleic acid4510.5PAEP, LIF, CGB5, CGA
39ascorbic acid45 2411.4CGA, CHKB, LIF, CGB5
40tamoxifen45 50 29 1113.4CGA, PAEP, CHKB, CGB5
41estradiol45 11 2412.4HOXA10, CHKB, CGB, PAEP, LIF, CGB7
42vegf4510.4PROK1, PROKR1, CGB5, PAEP, CGB, LIF
43steroid4510.4CHKB, PROK1, HOXA10, PAEP, CGB5, LIF
448-bromo-cyclic amp4510.3CGA, CGB5
45testosterone45 60 11 2413.3CGA, CGB5, CGB7, CGB, LIF, CHKB
46polysaccharide4510.2PAEP, CHKB, LIF, CGB5
47norepinephrine45 11 2412.2CGA, CHKB, CGB5, LIF
48latex4510.2LIF, CHKB, SCGB1A1
49dihydroprogesterone4510.0CGA, CGB5
50progesterone45 60 29 11 2414.0DKK1, HOXA10, CGB7, CGB, PROK1, CGA

GO Terms for genes affiliated with Ectopic Pregnancy

Sources:
16Gene Ontology
See all sources

Cellular components related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0PAEP, INHBA, INHBB, PROK1, CGB, CGA

Biological processes related to Ectopic Pregnancy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ovulationGO:06027910.5INHBA, INHBB
2embryo implantationGO:00756610.5TRO, LIF, SCGB1A1
3positive regulation of follicle-stimulating hormone secretionGO:04688110.4INHBA, INHBB
4embryonic limb morphogenesisGO:03032610.4DKK1, HOXA11, HOXA10
5negative regulation of follicle-stimulating hormone secretionGO:04688210.4INHBB, INHBA
6decidualizationGO:04669710.3LIF, SFRP4
7defense responseGO:00695210.2INHBA, INHBB, CRISP3
8activin receptor signaling pathwayGO:03292410.2INHBB, INHBA
9peptide hormone processingGO:01648610.1CGB, CGA

Molecular functions related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide Y receptor activityGO:00498310.3PROKR2, PROKR1
2growth factor activityGO:00808310.0INHBA, INHBB, DKK1, LIF, PROK1
3hormone activityGO:0051799.9CGA, CGB, INHBB, INHBA

Products for genes affiliated with Ectopic Pregnancy

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Sources for Ectopic Pregnancy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet