MCID: ECT026
MIFTS: 38

Ectopic Pregnancy malady

Summaries for Ectopic Pregnancy

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The uterus, or womb, is an important female reproductive organ. it is the place where a baby grows when a woman is pregnant. if you have an ectopic pregnancy, the fertilized egg grows in an abnormal place, outside the uterus, usually in the fallopian tubes. the result is usually a miscarriage. ectopic pregnancy can be a medical emergency if it ruptures. signs of ectopic pregnancy include abdominal pain shoulder pain vaginal bleeding feeling dizzy or faint get medical care right away if you have these signs. doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. many women who have had ectopic pregnancies go on to have healthy pregnancies later. dept. of health and human services office on women's health

MalaCards: Ectopic Pregnancy, also known as pregnancy ectopic, is related to choriocarcinoma and infertility. An important gene associated with Ectopic Pregnancy is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and Selected targets of Oct-3/4. The drug mifepristone and the compounds 11-ketotestosterone and mit1 have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:63 An ectopic pregnancy, or eccysis, is a complication of pregnancy in which the embryo implants outside... more...

Aliases & Classifications for Ectopic Pregnancy

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 60UMLS, 44Novoseek, 25ICD10
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Classifications:



Aliases & Descriptions:

ectopic pregnancy 42 33 60
pregnancy ectopic 44


External Ids:

ICD1025 O00

Related Diseases for Ectopic Pregnancy

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17GeneCards, 18GeneDecks
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Diseases related to Ectopic Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma30.6CGB5, CGB7, LIF, CGB, CGA
2infertility30.6CGA, CGB, TRO, LIF, HOXA10, PAEP
3ovarian cyst30.5PAEP, CGB5, CGA
4endometriosis30.4LIF, PAEP, HOXA10, CGA
5leukemia30.3HOXA10, HOXA11, SCGB1A1, PAEP, LIF, CGB
6placental site trophoblastic tumor30.1CGA, CGB, CGB5
7sarcoma30.1CGB, CGB5
8peritonitis29.9LIF
9polycystic ovary syndrome29.9CGA, CGB5, PROK1
10ovarian cancer29.9CGB5, CGB, LIF, PAEP
11gestational trophoblastic neoplasm29.9CGB5, PAEP, CGA, CGB, CGB7
12hyperprolactinemia29.9CGB, CGB5, CGA
13hypogonadism29.9CGB5, PROKR2, CGA
14adenoma29.9CGA, PAEP, CGB7, CGB, INHBA, LIF
15adenocarcinoma29.9PAEP, INHBA, LIF, CGB, CGB5, CRISP3
16cervicitis10.6
17salpingitis10.4
18pelvic inflammatory disease10.4
19ovarian hyperstimulation syndrome10.3
20gestational choriocarcinoma10.3
21appendicitis10.2
22cystic teratoma10.2
23tuberculous salpingitis10.2
24fallopian tube endometriosis10.2
25endometriosis of ovary10.2
26corpus luteum cyst10.1
27myoma10.1
28cervix endometriosis10.1
29ovarian endometriosis10.1
30salpingitis isthmica nodosa10.1
31acromegaly10.1
32fallopian tube teratoma10.1
33adenomatoid tumor10.1
34mature teratoma10.1
35ovary sarcoma10.1
36schistosomiasis10.1
37tuberculosis10.1
38vaginitis10.1
39obesity10.0LIF
40thyroiditis10.0CGA
41melanoma10.0CGB, CHKB
42leydig cell tumor10.0CGA, CGB5
43germinoma10.0CGB5, CGB, CGA
44multiple myeloma10.0DKK1
45leiomyoma10.0PAEP
46gestational trophoblastic tumor10.0CGB5, CGB, CGA
47dysgerminoma10.0CGA, CGB5
48hyperthyroidism10.0CGB, CGB5, CGA
49gynecomastia10.0CGB5, CGA
50seminoma10.0CGB, CGB5, CGB7, CGA

Graphical network of the top 20 diseases related to Ectopic Pregnancy:



Diseases related to ectopic pregnancy

Clinical Features for Ectopic Pregnancy

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Drugs & Therapeutics for Ectopic Pregnancy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ectopic Pregnancy

Drug clinical trials:

Search ClinicalTrials for Ectopic Pregnancy

Search NIH Clinical Center for Ectopic Pregnancy

Search CenterWatch for Ectopic Pregnancy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Ectopic Pregnancy

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Anatomical Context for Ectopic Pregnancy

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32MalaCards
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MalaCards organs/tissues related to Ectopic Pregnancy:

32
Ovary, Uterus, Cervix

Animal Models for Ectopic Pregnancy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ectopic Pregnancy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.9SCGB1A1, PROKR2, LIF, HOXA11, HOXA10, INHBB
2MP:00053899.7INHBA, SFRP4, CRISP3, CGA, PROKR1, PROKR2
3MP:00107689.7SCGB1A1, PROKR1, PROKR2, LIF, TRO, DKK1
4MP:00053769.4SFRP4, SCGB1A1, CGA, PROKR1, PROKR2, LIF

Publications for Ectopic Pregnancy

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Genetic Variations for Ectopic Pregnancy

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Expression for genes affiliated with Ectopic Pregnancy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ectopic Pregnancy

Search GEO for disease gene expression data for Ectopic Pregnancy.

Pathways for genes affiliated with Ectopic Pregnancy

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53Reactome, 12EMD Millipore
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Pathways related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CGB, CGA
210.2INHBB, DKK1, CGB, CGB7

Compounds for genes affiliated with Ectopic Pregnancy

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Ectopic Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4410.7CGB5, CGA
2mit12810.7PROKR2, PROKR1
3pge24410.7PAEP
4prokineticin-2β2810.7PROKR1, PROKR2
5prokineticin-12810.7PROKR1, PROKR2
6prokineticin-22810.7PROKR2, PROKR1
7estrogen4410.7HOXA10, PAEP, CHKB
8onapristone44 2811.7CGA, LIF, PAEP
9oestradiol valerate4410.7PAEP, CGA
10buserelin44 28 1112.7PAEP, CGA, CGB5
11oestriol4410.7CGB, CGB7, CGB5, CGA
12organon4410.7CGA, CGB5
13ctp4410.7CGB5, CGB7, CGA, CGB
14ifosfamide44 1111.6CGA, CGB, CGB5
15clomiphene citrate4410.6PAEP, CGA, CGB, CGB5
16diethylstilbestrol44 28 1112.6HOXA10, CGB5, CGA
17bleomycin44 1111.6CGA, CGB5, CGB7, CGB
18percoll4410.6CRISP3, CGB5, CGA
19cycloheximide4410.6HOXA10, CGB5
20androstenedione44 2411.6CGB, CGB5, CGA, PAEP
21trilostane44 1111.6CGB5, CGA
22prostaglandin f2alpha4410.6CGA, CGB5, LIF
23thyroxine44 2411.6CGB7, CGA, CGB, CHKB
24progestin4410.6PAEP, CGA, LIF, CGB5
25phenylephrine44 28 11 2413.6LIF, CGB5, CGA
26methotrexate44 49 1112.6CGB, CHKB, CGA, CGB5, CGB7
27mifepristone44 59 28 1113.6CGB5, LIF, CGA, PAEP, CGB
28etoposide44 49 59 1113.6CGB7, CGB, CGB5
29estradiol benzoate4410.5CGB5, CGA
30prostaglandin4410.5LIF, HOXA10, PAEP, CGB5, CGA
31gnrh4410.5CGB7, CGA, INHBB, CGB, CGB5
32dbc-amp4410.5LIF, CGB5, CGA
3317-hydroxypregnenolone4410.5CGA, CGB5
34lactate4410.5CGB7, CGA, CHKB, LIF, CGB, CGB5
35creatinine4410.5CGA, SCGB1A1, CGB5, CHKB, CGB, LIF
36cisplatin44 49 59 1113.5LIF, CGB, CGA, CGB5, CGB7
37leuprolide44 59 28 1113.5CGA, CGB5
38ribonucleic acid4410.5PAEP, LIF, CGB5, CGA
39ascorbic acid44 2411.4CGA, CHKB, LIF, CGB5
40tamoxifen44 49 28 1113.4CGA, PAEP, CHKB, CGB5
41estradiol44 11 2412.4HOXA10, CHKB, CGB, PAEP, LIF, CGB7
42vegf4410.4PROK1, PROKR1, CGB5, PAEP, CGB, LIF
43steroid4410.4CHKB, PROK1, HOXA10, PAEP, CGB5, LIF
448-bromo-cyclic amp4410.3CGA, CGB5
45testosterone44 59 11 2413.3CGA, CGB5, CGB7, CGB, LIF, CHKB
46polysaccharide4410.2PAEP, CHKB, LIF, CGB5
47norepinephrine44 11 2412.2CGA, CHKB, CGB5, LIF
48latex4410.2LIF, CHKB, SCGB1A1
49dihydroprogesterone4410.0CGA, CGB5
50progesterone44 59 28 11 2414.0DKK1, HOXA10, CGB7, CGB, PROK1, CGA

GO Terms for genes affiliated with Ectopic Pregnancy

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16Gene Ontology
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Cellular components related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0PAEP, INHBA, INHBB, PROK1, CGB, CGA

Biological processes related to Ectopic Pregnancy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ovulationGO:06027910.5INHBA, INHBB
2embryo implantationGO:00756610.5TRO, LIF, SCGB1A1
3positive regulation of follicle-stimulating hormone secretionGO:04688110.4INHBA, INHBB
4embryonic limb morphogenesisGO:03032610.4DKK1, HOXA11, HOXA10
5negative regulation of follicle-stimulating hormone secretionGO:04688210.4INHBB, INHBA
6decidualizationGO:04669710.3LIF, SFRP4
7defense responseGO:00695210.2INHBA, INHBB, CRISP3
8activin receptor signaling pathwayGO:03292410.2INHBB, INHBA
9peptide hormone processingGO:01648610.1CGB, CGA

Molecular functions related to Ectopic Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide Y receptor activityGO:00498310.3PROKR2, PROKR1
2growth factor activityGO:00808310.0INHBA, INHBB, DKK1, LIF, PROK1
3hormone activityGO:0051799.9CGA, CGB, INHBB, INHBA

Products for genes affiliated with Ectopic Pregnancy

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  • Antibodies
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Sources for Ectopic Pregnancy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet