MCID: ECT003
MIFTS: 27

Ectopic Thymus malady

Category: Immune diseases

Aliases & Classifications for Ectopic Thymus

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Aliases & Descriptions for Ectopic Thymus:

Name: Ectopic Thymus 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:6307
NCIt45 C27804

Summaries for Ectopic Thymus

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Wikipedia:71 Ectopic thymus is a condition where thymus tissue is found in an abnormal location. more...

MalaCards based summary: Ectopic Thymus is related to cervicitis and thyroiditis. An important gene associated with Ectopic Thymus is TFAP2A (Transcription Factor AP-2 Alpha), and among its related pathways are Apoptosis and Autophagy and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include thymus and thyroid, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and hearing/vestibular/ear.

Related Diseases for Ectopic Thymus

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Diseases related to Ectopic Thymus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis10.1
2thyroiditis9.9
3thoracic outlet syndrome9.8BCL2, SYP
4kidney disease9.7BCL2, SYP
5branchiooculofacial syndrome9.6
6hemangioma9.6
7leukemia9.6
8myasthenia gravis9.6
9lymphoblastic leukemia9.6
10papillary carcinoma9.6
11thymoma9.6
12cavernous hemangioma9.6
13cleft lip9.6
14dysphagia9.6
15myositis9.2BCL2, FOXN1, OMG, SYP, TFAP2A
16pineal region yolk sac tumor9.2BCL2, FOXN1, OMG, SYP, TFAP2A

Graphical network of diseases related to Ectopic Thymus:



Diseases related to ectopic thymus

Symptoms & Phenotypes for Ectopic Thymus

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GenomeRNAi Phenotypes related to Ectopic Thymus according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.9BCL2, TFAP2A

MGI Mouse Phenotypes related to Ectopic Thymus according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6BCL2, FOXN1, TFAP2A
2MP:00028739.0FOXN1, OMG, SYP, TFAP2A
3MP:00011868.7BCL2, FOXN1, TFAP2A

Drugs & Therapeutics for Ectopic Thymus

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Drugs for Ectopic Thymus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Octreotideapproved, investigationalPhase 1, Phase 222383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
2RadiopharmaceuticalsPhase 1, Phase 2514
3Fluorodeoxyglucose F18Phase 1, Phase 2412
4DihydroxyphenylalaninePhase 1, Phase 2143

Interventional clinical trials:

idNameStatusNCT IDPhase
1New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing SyndromeRecruitingNCT00001849Phase 1, Phase 2

Search NIH Clinical Center for Ectopic Thymus

Genetic Tests for Ectopic Thymus

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Anatomical Context for Ectopic Thymus

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MalaCards organs/tissues related to Ectopic Thymus:

36
Thymus, Thyroid

Publications for Ectopic Thymus

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Articles related to Ectopic Thymus:

(show all 36)
idTitleAuthorsYear
1
Intrathyroidal Ectopic Thymus in Children: Retrospective Analysis of Grayscale and Doppler Sonographic Features. (26269296)
2015
2
Ectopic thymus presenting as a retropharyngeal mass: surgical approach. (23354892)
2013
3
Thrombosed cavernous hemangioma arising in cervical ectopic thymus tissue: a case report. (23248863)
2012
4
Active ectopic thymus predicts poor outcome after thymectomy in class III myasthenia gravis. (22177829)
2012
5
Sonographic appearance of intrathyroid ectopic thymus in children. (22362225)
2012
6
Branchiooculofacial syndrome and bilateral ectopic thymus: report of a family. (23106675)
2012
7
Clinical management of cervical ectopic thymus in children. (21843706)
2011
8
Radiology quiz case 2. Ectopic thymus. (21339410)
2011
9
Ectopic thymus presenting as neck mass in a neonate: a case report. (21654604)
2011
10
Cervical ectopic thymus masquerading as metastatic thyroid papillary carcinoma. (20614729)
2010
11
Vascularized tissue engineering mouse chamber model supports thymopoiesis of ectopic thymus tissue grafts. (19715386)
2010
12
Cervical ectopic thymus. (19177048)
2009
13
Cervical ectopic thymus in a 9-month-old girl: diagnostic difficulties. (19641469)
2009
14
Ectopic thymus presenting as a right-side cervical mass in an infant. (18839165)
2009
15
Inspiratory stridor and dysphagia in two newborn infants caused by ectopic thymus tissue. (19104836)
2009
16
Clear cell carcinoma originating from ectopic thymus. (19440827)
2009
17
Solid cervical ectopic thymus in an infant. (19573646)
2009
18
Case of right-neck tumor that appears to be ectopic thymus. (27277227)
2009
19
Ectopic thymus presenting as a thyroid nodule in a patient with the Carney complex. (19265501)
2009
20
Cervical ectopic thymus presenting as a painless neck mass in a child. (17966246)
2007
21
Cervical ectopic thymus in an infant. (16397725)
2006
22
Images in pathology: micronodular epithelial hyperplasia in ectopic thymus. (16501838)
2006
23
Ectopic thymus presenting as a subglottic mass: diagnostic and management dilemmas. (15763300)
2005
24
Ectopic thymus presenting as neck mass. (12508495)
2002
25
Cervical ectopic thymus: a case report and review of the literature. (12363426)
2002
26
The analogy in cell immunophenotype and parameters of cell cycle of ectopic thymus, normal thymus, and some acute lymphoblastic leukemia of T-phenotype. (12458329)
2002
27
Ectopic thymus presenting as a submandibular swelling. (11474464)
2001
28
Adult ectopic thymus adjacent to thyroid and parathyroid. (11371249)
2001
29
Ectopic thymus presenting as a solid submandibular neck mass in an infant: case report and review of literature. (10519705)
1999
30
Ectopic thymus presenting as a neck swelling in a newborn. (17341962)
1998
31
Malignant thymoma in an ectopic thymus: CT appearance. (1885808)
1991
32
Bilateral ectopic thymus gland tissue associated with the cleft lip and palate. (2748765)
1989
33
Ectopic thymus in the neck; a case report and review of the literature. (3676587)
1987
34
Ectopic thymus: presenting as neck mass. (6726580)
1984
35
Radiologic seminar CCVII: ectopic thymus. (7431388)
1980
36
Ectopic thymus of the neck--report of three examples in children. (1161677)
1975

Variations for Ectopic Thymus

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Expression for genes affiliated with Ectopic Thymus

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Search GEO for disease gene expression data for Ectopic Thymus.

Pathways for genes affiliated with Ectopic Thymus

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Pathways related to Ectopic Thymus according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2BCL2, TFAP2A
29.2BCL2, TFAP2A

GO Terms for genes affiliated with Ectopic Thymus

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Biological processes related to Ectopic Thymus according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1animal organ morphogenesisGO:00098879.8BCL2, FOXN1
2cellular response to organic substanceGO:00713109.7BCL2, SYP
3kidney developmentGO:00018229.7BCL2, TFAP2A
4hemopoiesisGO:00300979.7BCL2, FOXN1
5negative regulation of reactive oxygen species metabolic processGO:20003789.7BCL2, TFAP2A
6lymphocyte homeostasisGO:00022609.7BCL2, FOXN1
7axonogenesisGO:00074099.7BCL2, OMG
8T cell homeostasisGO:00430299.6BCL2, FOXN1
9T cell lineage commitmentGO:00023609.6BCL2, FOXN1
10thymus developmentGO:00485389.1BCL2, FOXN1

Molecular functions related to Ectopic Thymus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:000098110.2FOXN1, TFAP2A
2sequence-specific DNA bindingGO:00435658.7BCL2, FOXN1, TFAP2A

Sources for Ectopic Thymus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet