MCID: ECT003
MIFTS: 27

Ectopic Thymus malady

Categories: Immune diseases

Aliases & Classifications for Ectopic Thymus

Aliases & Descriptions for Ectopic Thymus:

Name: Ectopic Thymus 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6307
NCIt 47 C27804
UMLS 69 C1333375

Summaries for Ectopic Thymus

MalaCards based summary : Ectopic Thymus is related to cervicitis and thyroiditis. An important gene associated with Ectopic Thymus is TFAP2A (Transcription Factor AP-2 Alpha), and among its related pathways/superpathways are Apoptosis and Autophagy and Corticotropin-releasing hormone signaling pathway. The drugs Octreotide and Dihydroxyphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include thymus and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hearing/vestibular/ear

Wikipedia : 71 Ectopic thymus is a condition where thymus tissue is found in an abnormal... more...

Related Diseases for Ectopic Thymus

Diseases related to Ectopic Thymus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 cervicitis 10.1
2 thyroiditis 9.9
3 thoracic outlet syndrome 9.8 BCL2 SYP
4 kidney disease 9.7 BCL2 SYP
5 branchiooculofacial syndrome 9.6
6 hemangioma 9.6
7 leukemia 9.6
8 myasthenia gravis 9.6
9 lymphoblastic leukemia 9.6
10 papillary carcinoma 9.6
11 thymoma 9.6
12 cavernous hemangioma 9.6
13 cleft lip 9.6
14 dysphagia 9.6
15 myositis 9.2 BCL2 FOXN1 OMG SYP TFAP2A
16 pineal region yolk sac tumor 9.2 BCL2 FOXN1 OMG SYP TFAP2A

Graphical network of the top 20 diseases related to Ectopic Thymus:



Diseases related to Ectopic Thymus

Symptoms & Phenotypes for Ectopic Thymus

GenomeRNAi Phenotypes related to Ectopic Thymus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.66 BCL2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 BCL2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.66 BCL2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.66 TFAP2A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.66 TFAP2A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.66 BCL2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 TFAP2A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.66 BCL2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.66 TFAP2A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.66 BCL2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.66 BCL2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.66 TFAP2A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.66 BCL2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.66 TFAP2A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.66 BCL2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.66 TFAP2A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.66 TFAP2A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.66 TFAP2A BCL2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 BCL2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.66 BCL2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.66 BCL2

MGI Mouse Phenotypes related to Ectopic Thymus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.33 TFAP2A BCL2 FOXN1
2 normal MP:0002873 9.26 FOXN1 OMG SYP TFAP2A
3 pigmentation MP:0001186 8.8 BCL2 FOXN1 TFAP2A

Drugs & Therapeutics for Ectopic Thymus

Drugs for Ectopic Thymus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 1, Phase 2 83150-76-9 383414 6400441
2 Dihydroxyphenylalanine Phase 1, Phase 2
3 Fluorodeoxyglucose F18 Phase 1, Phase 2
4 Radiopharmaceuticals Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome Recruiting NCT00001849 Phase 1, Phase 2

Search NIH Clinical Center for Ectopic Thymus

Genetic Tests for Ectopic Thymus

Anatomical Context for Ectopic Thymus

MalaCards organs/tissues related to Ectopic Thymus:

39
Thymus, Thyroid

Publications for Ectopic Thymus

Articles related to Ectopic Thymus:

(show all 36)
id Title Authors Year
1
Intrathyroidal Ectopic Thymus in Children: Retrospective Analysis of Grayscale and Doppler Sonographic Features. ( 26269296 )
2015
2
Ectopic thymus presenting as a retropharyngeal mass: surgical approach. ( 23354892 )
2013
3
Thrombosed cavernous hemangioma arising in cervical ectopic thymus tissue: a case report. ( 23248863 )
2012
4
Active ectopic thymus predicts poor outcome after thymectomy in class III myasthenia gravis. ( 22177829 )
2012
5
Sonographic appearance of intrathyroid ectopic thymus in children. ( 22362225 )
2012
6
Branchiooculofacial syndrome and bilateral ectopic thymus: report of a family. ( 23106675 )
2012
7
Clinical management of cervical ectopic thymus in children. ( 21843706 )
2011
8
Radiology quiz case 2. Ectopic thymus. ( 21339410 )
2011
9
Ectopic thymus presenting as neck mass in a neonate: a case report. ( 21654604 )
2011
10
Cervical ectopic thymus masquerading as metastatic thyroid papillary carcinoma. ( 20614729 )
2010
11
Vascularized tissue engineering mouse chamber model supports thymopoiesis of ectopic thymus tissue grafts. ( 19715386 )
2010
12
Cervical ectopic thymus. ( 19177048 )
2009
13
Cervical ectopic thymus in a 9-month-old girl: diagnostic difficulties. ( 19641469 )
2009
14
Ectopic thymus presenting as a right-side cervical mass in an infant. ( 18839165 )
2009
15
Inspiratory stridor and dysphagia in two newborn infants caused by ectopic thymus tissue. ( 19104836 )
2009
16
Clear cell carcinoma originating from ectopic thymus. ( 19440827 )
2009
17
Solid cervical ectopic thymus in an infant. ( 19573646 )
2009
18
Case of right-neck tumor that appears to be ectopic thymus. ( 27277227 )
2009
19
Ectopic thymus presenting as a thyroid nodule in a patient with the Carney complex. ( 19265501 )
2009
20
Cervical ectopic thymus presenting as a painless neck mass in a child. ( 17966246 )
2007
21
Cervical ectopic thymus in an infant. ( 16397725 )
2006
22
Images in pathology: micronodular epithelial hyperplasia in ectopic thymus. ( 16501838 )
2006
23
Ectopic thymus presenting as a subglottic mass: diagnostic and management dilemmas. ( 15763300 )
2005
24
Ectopic thymus presenting as neck mass. ( 12508495 )
2002
25
Cervical ectopic thymus: a case report and review of the literature. ( 12363426 )
2002
26
The analogy in cell immunophenotype and parameters of cell cycle of ectopic thymus, normal thymus, and some acute lymphoblastic leukemia of T-phenotype. ( 12458329 )
2002
27
Ectopic thymus presenting as a submandibular swelling. ( 11474464 )
2001
28
Adult ectopic thymus adjacent to thyroid and parathyroid. ( 11371249 )
2001
29
Ectopic thymus presenting as a solid submandibular neck mass in an infant: case report and review of literature. ( 10519705 )
1999
30
Ectopic thymus presenting as a neck swelling in a newborn. ( 17341962 )
1998
31
Malignant thymoma in an ectopic thymus: CT appearance. ( 1885808 )
1991
32
Bilateral ectopic thymus gland tissue associated with the cleft lip and palate. ( 2748765 )
1989
33
Ectopic thymus in the neck; a case report and review of the literature. ( 3676587 )
1987
34
Ectopic thymus: presenting as neck mass. ( 6726580 )
1984
35
Radiologic seminar CCVII: ectopic thymus. ( 7431388 )
1980
36
Ectopic thymus of the neck--report of three examples in children. ( 1161677 )
1975

Variations for Ectopic Thymus

Expression for Ectopic Thymus

Search GEO for disease gene expression data for Ectopic Thymus.

Pathways for Ectopic Thymus

Pathways related to Ectopic Thymus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.22 BCL2 TFAP2A
2 10.59 BCL2 TFAP2A

GO Terms for Ectopic Thymus

Biological processes related to Ectopic Thymus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.48 BCL2 OMG
2 animal organ morphogenesis GO:0009887 9.46 BCL2 FOXN1
3 kidney development GO:0001822 9.43 BCL2 TFAP2A
4 hemopoiesis GO:0030097 9.4 BCL2 FOXN1
5 thymus development GO:0048538 9.37 BCL2 FOXN1
6 cellular response to organic substance GO:0071310 9.32 BCL2 SYP
7 T cell homeostasis GO:0043029 9.26 BCL2 FOXN1
8 negative regulation of reactive oxygen species metabolic process GO:2000378 9.16 BCL2 TFAP2A
9 lymphocyte homeostasis GO:0002260 8.96 BCL2 FOXN1
10 T cell lineage commitment GO:0002360 8.62 BCL2 FOXN1

Molecular functions related to Ectopic Thymus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 8.96 FOXN1 TFAP2A
2 sequence-specific DNA binding GO:0043565 8.8 BCL2 FOXN1 TFAP2A

Sources for Ectopic Thymus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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