Aliases & Classifications for Ectropion

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Aliases & Descriptions for Ectropion:

Name: Ectropion 11 27 50 39 13
Ectropion of Eyelid 11
 
Everted Margin 11

Classifications:



External Ids:

Disease Ontology11 DOID:1570
ICD9CM32 374.1, 374.10
MeSH39 D004483

Summaries for Ectropion

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Wikipedia:71 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

MalaCards based summary: Ectropion, also known as ectropion of eyelid, is related to ichthyosis, autosomal recessive 4b and neu-laxova syndrome1. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways are Glycine, serine and threonine metabolism and Amino acid synthesis and interconversion (transamination). Affiliated tissues include skin, eye and cervix, and related mouse phenotypes are craniofacial and liver/biliary system.

Related Diseases for Ectropion

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Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis, autosomal recessive 4b31.6ABCA12, TGM1
2neu-laxova syndrome131.5PHGDH, PSAT1
3cicatricial ectropion12.0
4congenital ectropion uveae12.0
5senile ectropion12.0
6mechanical ectropion11.9
7spastic ectropion11.9
8isolated congenital ectropion11.9
9barber-say syndrome11.8
10ichthyosis with alopecia, eclabium, ectropion, and mental retardation11.8
11ichthyosis alopecia eclabion ectropion mental retardation11.7
12blepharocheilodontic syndrome11.5
13ichthyosis, congenital, autosomal recessive 4a10.9
14ichthyosis, congenital, autosomal recessive 110.9
15mandibulofacial dysostosis with macroblepharon and macrostomia10.7
16jones hersh yusk syndrome10.7
17ichthyosis, congenital, autosomal recessive 610.7
18ichthyosis, congenital, autosomal recessive 1010.7
19neu-laxova syndrome 210.7
20ichthyosis, congenital, autosomal recessive 810.7
21ichthyosis, congenital, autosomal recessive 1110.7
22ichthyosis, congenital, autosomal recessive 710.7
23ichthyosis, congenital, autosomal recessive 910.7
24ichthyosis, congenital, autosomal recessive 210.7
25ichthyosis, congenital, autosomal recessive 310.7
26ichthyosis, congenital, autosomal recessive 510.7
27keratosis follicularis spinulosa decalvans, x-linked10.7
28euryblepharon10.3
29entropion10.3
30autism x-linked 410.2MBTPS2, SAT1
31ulerythema ophryogenesis10.2MBTPS2, SAT1
32intracranial hypertension10.1MBTPS2, SAT1
33ocular motility disease10.1ABCA12, TGM1
34cervicitis10.1
35uterine ligament clear cell adenocarcinoma10.0ABCA12, TGM1
36malignant ovarian brenner tumor10.0MBTPS2, SAT1
37ichthyosis vulgaris10.0ABCA12, TGM1
38bscl2-related neurologic disorders/seipinopathy9.9ABCA12, TGM1
39steroid inherited metabolic disorder9.9ABCA12, TGM1
40burns9.9
41ptosis9.9
42lagophthalmos9.9
43facial paralysis9.9
44ichthyosis, cyclic, with epidermolytic hyperkeratosis9.8ABCA12, TGM1
45senile entropion9.8
46vaginitis9.8
47pyoderma9.8
48pyoderma gangrenosum9.8
49distichiasis9.7
50juvenile glaucoma9.7

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to ectropion

Symptoms & Phenotypes for Ectropion

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MGI Mouse Phenotypes related to Ectropion according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.7ABCA12, NF1, PSAT1, TWIST2
2MP:00053708.6DNAAF3, NF1, SAT1, TWIST2
3MP:00053848.3ABCA12, DNAAF3, NF1, PHGDH, SAT1, TWIST2
4MP:00053767.9ABCA12, NF1, PHGDH, PSAT1, SAT1, TGM1
5MP:00053787.5ABCA12, DNAAF3, NF1, PHGDH, PSAT1, SAT1

Drugs & Therapeutics for Ectropion

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Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FluorouracilapprovedEarly Phase 1179151-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
2Immunosuppressive AgentsEarly Phase 112770
3Antimetabolites, AntineoplasticEarly Phase 17171
4AntimetabolitesEarly Phase 111774

Interventional clinical trials:

idNameStatusNCT IDPhase
1Hyaluronic Acid Gels for Lower Lid RetractionWithdrawnNCT01838252Phase 4
2PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic SurgeryWithdrawnNCT02761083Phase 4
3Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine CutaneousUnknown statusNCT01222000Phase 3
4Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection)CompletedNCT02893813
5Lacrimal Drainage Resistance StudyCompletedNCT01766232
65-fluorouracil Versus Placebo in Periocular Full Thickness Skin GraftsNot yet recruitingNCT02705352Early Phase 1
7Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface SurgeriesNot yet recruitingNCT02638610

Search NIH Clinical Center for Ectropion


Cochrane evidence based reviews: ectropion

Genetic Tests for Ectropion

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Genetic tests related to Ectropion:

id Genetic test Affiliating Genes
1 Ectropion27

Anatomical Context for Ectropion

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MalaCards organs/tissues related to Ectropion:

36
Skin, Eye, Cervix, Testes, Lung, Bone

Publications for Ectropion

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Articles related to Ectropion:

(show top 50)    (show all 435)
idTitleAuthorsYear
1
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. (27768224)
2017
2
Is it safe to use N-acetylcysteineA in the treatment of bilateralA ectropion on collodion baby? (28083950)
2017
3
Misdiagnosed Periocular Pyoderma Gangrenosum Requiring Ectropion Repair With Development of Second Lesion of Pyoderma Gangrenosum at Graft Site. (26934168)
2016
4
Modified lateral tarsal strip for involutional entropion and ectropion surgery. (27817116)
2016
5
Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis. (27974983)
2016
6
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. (27191780)
2016
7
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. (27893584)
2016
8
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. (27529153)
2016
9
Primary Horizontal Closure With Suspension Sutures for Infraorbital Defects to Achieve Aesthetically Superior Closure and Prevent Ectropion. (27224889)
2016
10
Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. (26859652)
2016
11
Transposed Corrugator Supercilii Muscle-Tendon Unit Flap for Contralateral Paralytic Medial Ectropion Repair. (26987020)
2016
12
Tarsal Strip Versus Tarsal Belt in Ectropion Correction: A Statistical Evaluation. (27755408)
2016
13
Lipograft in cicatricial ectropion. (27842016)
2016
14
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. (26674895)
2016
15
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. (27429229)
2016
16
The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion. (27785003)
2016
17
Frangipane's Penitent's ectropion. (27986438)
2016
18
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. (26164158)
2015
19
Post-Blepharoplasty Hematoma Caused Lower-Lid Ectropion and Early Correction. (26468816)
2015
20
Superficial Temporal Artery Island Flap for Cicatricial Ectropion. (26079124)
2015
21
Reply: Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. (26186346)
2015
22
The hybrid approach for reconstruction of severely destructed lower eyelids: combination of skin grafting, temporary tarsorrhaphy, and autologous fat grafting for cicatricial ectropion after injection of commercial grade silicone. (25569426)
2015
23
Eyelid Necrosis and Secondary Cicatrical Ectropion Secondary to Levamisole-Associated Vasculitis. (26398243)
2015
24
Frontal osteomyelitis presenting as upper eyelid ectropion: A cautionary tale. (26155088)
2015
25
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. (25794020)
2015
26
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". (25945875)
2015
27
Lower lid ectropion in hypohidrotic ectodermal dysplasia. (25802783)
2015
28
Eyelid Finger Manipulation in the Treatment of Over-Corrected Blepharoptosis and Post-Blepharoplasty Ectropion-Retraction. (25724054)
2015
29
Use of amniotic membrane graft in the surgical management of cicatricial ectropion associated with cetuximab therapy. (25576167)
2015
30
Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. (26186347)
2015
31
Long-Term Outcome of Combined Lateral Tarsal Strip With Temporal Permanent Tarsorrhaphy for Correction of Paralytic Ectropion Caused By Facial Nerve Palsy. (26086924)
2015
32
Punctal function in lacrimal drainage: the 'pipette sign' and functional ectropion. (25944074)
2015
33
Modified auricular cartilage sling for paralytic ectropion. (25840523)
2015
34
Non-surgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid. (25639983)
2015
35
Cicatricial ectropion secondary to psoriatic arthritis. (25810938)
2015
36
Erlotinib induced ectropion following papulopustular rash. (26236413)
2015
37
Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures. (25025386)
2014
38
Inverting Sutures With Systemic Retinoids and Lubrication Can Correct Ectropion in Ichthyosis. (25216196)
2014
39
Free transplantation of autogenous palmaris longus tendon in the repair of cicatricial ectropion of lower eyelid. (24693868)
2014
40
Re: "inverting sutures for tarsal ectropion (the leicester modified suture technique)". (24614559)
2014
41
Management of Cicatricial Ectropion Secondary to Pyoderma Gangrenosum. (24410585)
2014
42
Paralytic ectropion treatment with lateral periosteal flap canthoplasty and introduction of the ectropion severity score. (25289344)
2014
43
Re: "inverting sutures for tarsal ectropion (the leicester modified suture technique)". (24614558)
2014
44
Ectropion in a case of collodion baby. (25489540)
2014
45
Marginal ectropion induced by conjunctival ingrowth after levator resection surgery. (24952020)
2014
46
Cicatricial ectropion in grzybowski type of multiple eruptive keratoacanthomas. (24481503)
2014
47
Treatment of extrinsic ectropion on burned face with facial suspension technique. (24997529)
2014
48
Caruncular Fixation in Medial Canthal Tendon Repair: The Minimally Invasive Purse String Suture for Tendinous Laxity and Medial Ectropion. (24911533)
2014
49
Age-matched, case-controlled comparison of clinical indicators for development of entropion and ectropion. (24734167)
2014
50
A simple method for the treatment of cicatricial ectropion and eyelid contraction in patients with periocular burn: Vertical V-Y advancement of the eyelid. (25306087)
2014

Variations for Ectropion

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Expression for genes affiliated with Ectropion

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Search GEO for disease gene expression data for Ectropion.

Pathways for genes affiliated with Ectropion

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Pathways related to Ectropion according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2PHGDH, PSAT1
2
Show member pathways
9.2PHGDH, PSAT1

GO Terms for genes affiliated with Ectropion

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Biological processes related to Ectropion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratinizationGO:003142410.4ABCA12, TGM1
2keratinocyte differentiationGO:003021610.3ABCA12, TGM1
3L-serine biosynthetic processGO:00065649.7PHGDH, PSAT1
4neural tube developmentGO:00219159.7NF1, PHGDH
5spinal cord developmentGO:00215109.2NF1, PHGDH

Sources for Ectropion

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet