Aliases & Classifications for Ectropion

MalaCards integrated aliases for Ectropion:

Name: Ectropion 12 28 51 41 14
Ectropion of Eyelid 12
Everted Margin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1570
ICD9CM 34 374.1 374.10
MeSH 41 D004483
UMLS 69 C0013592

Summaries for Ectropion

MalaCards based summary : Ectropion, also known as ectropion of eyelid, is related to blepharocheilodontic syndrome 1 and ichthyosis, congenital, autosomal recessive 4b. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Adherens junction and Glycine, serine and threonine metabolism. The drugs Fluorouracil and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

Related Diseases for Ectropion

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 blepharocheilodontic syndrome 1 33.1 CDH1 CTNND1
2 ichthyosis, congenital, autosomal recessive 4b 32.1 ABCA12 TGM1
3 ichthyosis, congenital, autosomal recessive 4a 31.6 ABCA12 TGM1
4 neu-laxova syndrome 1 31.5 PHGDH PSAT1
5 ichthyosis, congenital, autosomal recessive 1 31.1 ABCA12 TGM1
6 euryblepharon 31.0 CDH1 CTNND1
7 distichiasis 30.0 CDH1 CTNND1
8 glaucoma 3, primary congenital, a 28.8 NF1 PAX6
9 ichthyosis alopecia eclabion ectropion mental retardation 12.1
10 cicatricial ectropion 12.1
11 congenital ectropion uveae 12.1
12 senile ectropion 12.1
13 mechanical ectropion 12.1
14 spastic ectropion 12.1
15 isolated congenital ectropion 12.0
16 barber-say syndrome 11.9
17 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 11.9
18 mandibulofacial dysostosis with macroblepharon and macrostomia 11.1
19 jones hersh yusk syndrome 10.9
20 corneal dystrophy, posterior polymorphous, 1 10.8
21 gorlin-chaudhry-moss syndrome 10.8
22 ichthyosis, congenital, autosomal recessive 2 10.8
23 keratosis follicularis spinulosa decalvans, x-linked 10.8
24 ichthyosis, congenital, autosomal recessive 11 10.8
25 ichthyosis, congenital, autosomal recessive 5 10.8
26 ichthyosis, congenital, autosomal recessive 3 10.8
27 ichthyosis, congenital, autosomal recessive 6 10.8
28 ichthyosis, congenital, autosomal recessive 8 10.8
29 ichthyosis, congenital, autosomal recessive 7 10.8
30 ichthyosis, congenital, autosomal recessive 9 10.8
31 ichthyosis, congenital, autosomal recessive 10 10.8
32 neu-laxova syndrome 2 10.8
33 blepharocheilodontic syndrome 2 10.8
34 congenital ichthyosiform erythroderma 10.8
35 sezary's disease 10.8
36 entropion 10.4
37 ichthyosis 10.3
38 cervicitis 10.2
39 granulomatous amebic encephalitis 10.1 PHGDH PSAT1
40 phosphoserine aminotransferase deficiency 10.1 PHGDH PSAT1
41 eyelid disease 10.0 ABCA12 TGM1
42 ichthyosis vulgaris 10.0 ABCA12 TGM1
43 chronic polyneuropathy 10.0 NF1 PHGDH
44 burns 10.0
45 ptosis 10.0
46 lagophthalmos 10.0
47 facial paralysis 10.0
48 serine deficiency 10.0 PHGDH PSAT1
49 vaginitis 9.9
50 macrostomia, isolated 9.9

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion

Symptoms & Phenotypes for Ectropion

MGI Mouse Phenotypes related to Ectropion:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.98 ABCA12 CDH1 CTNND1 NF1 PAX6 PHGDH
2 growth/size/body region MP:0005378 9.92 ABCA12 CDH1 NF1 PAX6 PHGDH PSAT1
3 homeostasis/metabolism MP:0005376 9.86 TGM1 TWIST2 ABCA12 CDH1 NF1 PAX6
4 craniofacial MP:0005382 9.8 ABCA12 NF1 PAX6 PSAT1 TWIST2
5 digestive/alimentary MP:0005381 9.77 CDH1 CTNND1 NF1 PAX6 TWIST2
6 integument MP:0010771 9.7 ABCA12 CDH1 CTNND1 NF1 PAX6 TGM1
7 mortality/aging MP:0010768 9.56 ABCA12 CDH1 CTNND1 NF1 PAX6 PHGDH
8 neoplasm MP:0002006 9.02 CDH1 CTNND1 NF1 PAX6 PHGDH

Drugs & Therapeutics for Ectropion

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2 Antimetabolites Phase 2
3 Antimetabolites, Antineoplastic Phase 2
4 Immunosuppressive Agents Phase 2
5
Ethanol Approved 64-17-5 702
6
Iodine Approved, Investigational 7553-56-2 807
7
acetic acid Approved, Nutraceutical 64-19-7 176
8 cadexomer iodine
9
Retinol acetate 127-47-9 10245972

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
4 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
5 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610
6 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
7 Lacrimal Drainage Resistance Study Completed NCT01766232
8 Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Recruiting NCT03150745

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

Genetic Tests for Ectropion

Genetic tests related to Ectropion:

# Genetic test Affiliating Genes
1 Ectropion 28

Anatomical Context for Ectropion

MalaCards organs/tissues related to Ectropion:

38
Skin, Eye, Cervix, Testes, Lung, Bone

Publications for Ectropion

Articles related to Ectropion:

(show top 50) (show all 460)
# Title Authors Year
1
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. ( 29346172 )
2018
2
Reversible cicatricial ectropion associated with EGFR inhibitors. ( 29336655 )
2018
3
Severe ectropion in lamellar ichthyosis managed medically with oral acitretin. ( 29334142 )
2018
4
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. ( 27768224 )
2017
5
Upper eyelid ectropion repair. ( 28928260 )
2017
6
Is it safe to use N-acetylcysteineA in the treatment of bilateralA ectropion on collodion baby? ( 28083950 )
2017
7
Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis. ( 28460993 )
2017
8
The Lateral Tarsal Strip for Paralytic Ectropion in Patients with Leprosy. ( 29200763 )
2017
9
Recurrent Lower Eyelid Ectropion After Graft Surgery Using Autogenous Palmaris Longus Tendon. ( 29227410 )
2017
10
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. ( 28658179 )
2017
11
Ectropion ( 28722958 )
2017
12
Congenital ectropion uveae with glaucoma: a case report. ( 29027062 )
2017
13
Comparison of Polypropylene Sling with Combined Transconjunctival Retractor Plication and Lateral Tarsal Strip for Correction of Involutional Lower Eye Lid Ectropion. ( 29081868 )
2017
14
Newly identified paired box 6 mutation of variant familial aniridia: Congenital iris ectropion with foveal hypoplasia. ( 28300742 )
2017
15
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. ( 28746254 )
2017
16
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. ( 28314226 )
2017
17
Punctal Ectropion repair using the Raus-Garito clamp. ( 28853961 )
2017
18
Entropion and ectropion repair: a snapshot of surgical practice in the United Kingdom. ( 29053043 )
2017
19
Congenital upper eyelids ectropion in Down's syndrome. ( 28194320 )
2017
20
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. ( 28380102 )
2017
21
Vertical-to-Horizontal Rotational Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel Surgical Technique. ( 29181406 )
2017
22
Congenital Ectropion Uveae with Glaucoma: A Case Report. ( 28764212 )
2017
23
Cicatricial ectropion in a patient treated with dupilumab. ( 29260094 )
2017
24
Ectropion, Lower Eyelid Reconstruction ( 29262075 )
2017
25
Subcuticular Suture Technique: Alternative to Frost Suture to Prevent Ectropion After Transcutaneous Incision of Lower Eyelid. ( 29038637 )
2017
26
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. ( 28815772 )
2017
27
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. ( 27529153 )
2016
28
Lipograft in cicatricial ectropion. ( 27842016 )
2016
29
The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion. ( 27785003 )
2016
30
Frangipane's Penitent's ectropion. ( 27986438 )
2016
31
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. ( 27191780 )
2016
32
Primary Horizontal Closure With Suspension Sutures for Infraorbital Defects to Achieve Aesthetically Superior Closure and Prevent Ectropion. ( 27224889 )
2016
33
Tarsal Strip Versus Tarsal Belt in Ectropion Correction: A Statistical Evaluation. ( 27755408 )
2016
34
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2016
35
Transposed Corrugator Supercilii Muscle-Tendon Unit Flap for Contralateral Paralytic Medial Ectropion Repair. ( 26987020 )
2016
36
Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis. ( 27974983 )
2016
37
A young Botswana patient with congenital iris ectropion uvea. ( 28154731 )
2016
38
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2016
39
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2016
40
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. ( 26674895 )
2016
41
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. ( 26859652 )
2016
42
Misdiagnosed Periocular Pyoderma Gangrenosum Requiring Ectropion Repair With Development of Second Lesion of Pyoderma Gangrenosum at Graft Site. ( 26934168 )
2016
43
Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. ( 26186347 )
2015
44
Eyelid Finger Manipulation in the Treatment of Over-Corrected Blepharoptosis and Post-Blepharoplasty Ectropion-Retraction. ( 25724054 )
2015
45
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". ( 25945875 )
2015
46
Frontal osteomyelitis presenting as upper eyelid ectropion: A cautionary tale. ( 26155088 )
2015
47
Modified auricular cartilage sling for paralytic ectropion. ( 25840523 )
2015
48
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. ( 25794020 )
2015
49
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. ( 26164158 )
2015
50
Post-Blepharoplasty Hematoma Caused Lower-Lid Ectropion and Early Correction. ( 26468816 )
2015

Variations for Ectropion

Expression for Ectropion

Search GEO for disease gene expression data for Ectropion.

Pathways for Ectropion

GO Terms for Ectropion

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.5 NF1 PAX6 PHGDH
2 neural tube development GO:0021915 9.48 NF1 PHGDH
3 cellular amino acid biosynthetic process GO:0008652 9.46 PHGDH PSAT1
4 adherens junction organization GO:0034332 9.43 CDH1 CTNND1
5 spinal cord development GO:0021510 9.4 NF1 PHGDH
6 pituitary gland development GO:0021983 9.37 CDH1 PAX6
7 keratinocyte differentiation GO:0030216 9.33 ABCA12 PAX6 TGM1
8 entry of bacterium into host cell GO:0035635 9.26 CDH1 CTNND1
9 L-serine biosynthetic process GO:0006564 8.96 PHGDH PSAT1
10 brain development GO:0007420 8.92 CTNND1 NF1 PAX6 PHGDH

Molecular functions related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 CDH1 CTNND1

Sources for Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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