MCID: ECT005
MIFTS: 45

Ectropion malady

Eye diseases category

Summaries for Ectropion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

MalaCards: Ectropion, also known as ectropion, unspecified, is related to lagophthalmos and alopecia. An important gene associated with Ectropion is TGM1 (transglutaminase 1). The compound heme have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Ectropion

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

ectropion 8 10 44
ectropion, unspecified 8
unspecified ectropion 8
ectropion of eyelid 8
everted margin 8
ectropion nos 8


External Ids:

Disease Ontology8 DOID:1570
ICD9CM27 374.1, 374.10
MeSH34 D004483
ICD1025 H02.1

Related Diseases for Ectropion

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17GeneCards, 18GeneDecks
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Diseases related to Ectropion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1lagophthalmos30.3MBD5, LAX1
2alopecia29.7MBTPS2
3congenital ichthyosiform erythroderma29.7TGM1, ABCA12, ABHD5, CYP4F22
4cicatricial ectropion10.7
5entropion10.6
6glaucoma10.4
7senile ectropion10.4
8cervicitis10.4
9mechanical ectropion10.3
10senile entropion10.2
11facial paralysis10.2
12barber say syndrome10.2
13burns10.1
14spastic ectropion10.1
15vaginitis10.1
16ichthyosis alopecia eclabion ectropion mental retardation10.1
17blepharo-cheilo-odontic syndrome10.1
18ichthyosis - alopecia - eclabion - ectropion - intellectual deficit10.1
19neurofibromatosis10.0
20juvenile glaucoma10.0
21paralytic lagophthalmos10.0
22herpes zoster10.0
23basal cell carcinoma10.0
24hypertrichosis10.0
25ectropion inferior cleft lip and or palate10.0
26congenital ectropion uveae10.0
27ichthyosis vulgaris10.0TGM1
28keratosis follicularis spinulosa decalvans10.0SAT1
29keratosis follicularis10.0MBTPS2, SAT1
30harlequin type ichthyosis10.0ABCA12, TGM1
31neutral lipid storage disease10.0ABHD5, AADAC
32autosomal recessive congenital ichthyosis10.0ABCA12, CYP4F22, TGM1
33keratoconjunctivitis sicca10.0
34clear cell adenocarcinoma10.0
35cervical clear cell adenocarcinoma10.0
36pyoderma gangrenosum10.0
37sezary's disease10.0
38adenocarcinoma10.0
39cervical adenocarcinoma10.0
40corneal ulcer10.0
41keratoconjunctivitis10.0
42myasthenia gravis10.0
43papilloma10.0
44pyoderma10.0
45vaginal discharge10.0
46ichthyosis, autosomal recessive 4b10.0
47ichthyosis, congenital, autosomal recessive 110.0
48ichthyosis, congenital, autosomal recessive 210.0
49isolated congenital ectropion10.0
50cicatricial entropion9.8

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to ectropion

Clinical Features for Ectropion

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Drugs & Therapeutics for Ectropion

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ectropion

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Anatomical Context for Ectropion

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32MalaCards
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MalaCards organs/tissues related to Ectropion:

32
Skin, Eye, Cervix, Bone, Lung, Testes

Animal Models for Ectropion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ectropion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.0ABHD5, NF1, UROS, MBD5, SAT1
2MP:00107717.2TGM1, MBD5, UROS, NF1, ABHD5, ABCA12
3MP:00053786.7SAT1, MBD5, UROS, NF1, ABHD5, ABCA12
4MP:00053766.5SAT1, MBD5, UROS, NF1, ABHD5, ABCA12

Publications for Ectropion

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50PubMed
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Articles related to Ectropion:

(show top 50)    (show all 380)
idTitleAuthorsYear
1
Severe chronic blepharitis and scarring ectropion associated with discoid lupus erythematosus. (22845188)
2013
2
The lateral tarsal strip in ectropion surgery: is it effective when performed in isolation? (22402697)
2012
3
Entropion-ectropion: the influence of axial globe length on lower eyelid malposition. (22581083)
2012
4
Involutional entropion and ectropion of the lower eyelid: prevalence and associated risk factors in the elderly population. (21415800)
2011
5
Using bipedicled myocutaneous Tripier flap to correct ectropion after excision of lower eyelid basal cell carcinoma. (21403553)
2011
6
A bilateral cicatricial ectropion and bilateral upper lid shortening caused by 5-fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency. (21077799)
2011
7
Maternal skin allograft for cicatricial ectropion in congenital icthyosis. (20090485)
2010
8
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. (20439802)
2010
9
Basal cell carcinoma masquerading as the chronic ectropion of lamellar ichthyosis. (18384607)
2008
10
Invited discussion: midface lifting as an adjunct procedure in lower eyelid ectropion repair. (18046144)
2007
11
Congenital iris ectropion as an indicator of variant aniridia. (16622108)
2006
12
Correspondence: avoiding lower eyelid ectropion after full thickness skin grafting. (16703868)
2006
13
Bilateral juvenile glaucoma with iridotrabecular dysgenesis, congenital ectropion uveae, and thickened corneal nerves. (15618973)
2005
14
Severe post thermal burn cicatricial ectropion with corneal ulceration: an illustrative case. (16554865)
2005
15
Presence of the R1748X mutation in the NF1 gene in a Brazilian patient with ectropion uveae. (15627836)
2004
16
Prevalence and associations with ectropion in an older population: the Blue Mountains Eye Study. (11446446)
2001
17
Ectropion caused by periocular dermatitis. (11174423)
2001
18
Prevention of ectropion in reconstruction of facial defects. (11400823)
2001
19
The lateral transorbital canthopexy for correction and prevention of ectropion: report of a procedure, grading system, and outcome study. (10925417)
2000
20
Temporary tarsorrhaphy suture to prevent or treat scleral show and ectropion secondary to laser resurfacing or laser blepharoplasty. (10987484)
2000
21
Surgical treatment of cicatricial ectropion in lamellar ichthyosis. (12045963)
1999
22
Not just a cervical ectropion. Three case reports of diethylstilbestrol (DES) exposed women presenting with vaginal discharge and cervical ectropion. (15512425)
1999
23
Low-dose methotrexate as an adjunctive therapy with surgery for ectropion complicating dermatomyositis. (8829501)
1996
24
Hypertrichosis, atrophic skin, ectropion, and macrostomia (Barber-Say syndrome): report of a new case. (8368246)
1993
25
Late presentation of congenital ectropion of the eyelids in a child with Down syndrome: a case report and review of the literature. (1533873)
1992
26
Angle closure glaucoma following a combined blepharoplasty and ectropion repair. (1390424)
1992
27
Extrinsic eyelid ectropion. (1872541)
1991
28
Floppy eyelid syndrome associated with marked lower eyelid ectropion. (2817070)
1989
29
Surgical correction of entropion and ectropion in the same lid. (3336659)
1988
30
Severe ectropion: repair with a modified Tripier flap. (3602157)
1987
31
V-Y advancement for anal ectropion. (3743303)
1986
32
Repair of anal stricture and mucosal ectropion by simple flap procedures. (3943427)
1986
33
The histopathology of involutional ectropion. (4038795)
1985
34
Lower eyelid ectropion following chemical face peeling. (6472784)
1984
35
Prevention of ectropion by horizontal shortening of the lower lid during blepharoplasty. (6614752)
1983
36
Management of paralytic ectropion. (7041761)
1981
37
Double wedge resection for severe involutional ectropion. (379728)
1979
38
Repair of entropion and ectropion. (361598)
1978
39
Cicatricial ectropion. (974864)
1976
40
Senile ectropion. (974868)
1976
41
Surgical correction of severe cicatricial ectropion caused by chickenpox. (4607136)
1974
42
Senile entropion and ectropion. (5480563)
1970
43
Observations on trachomatous entropion and ectropion. (5919261)
1966
44
PIGMENT SPOTS OF THE IRIS AND ECTROPION UVEAE. (14088677)
1963
45
Congenital ectropion and distichiasis; etiologic and hereditary factors: a report of cases and review of the literature. (13556836)
1957-1958
46
Cicatricial ectropion; report of the plastic repair of a bilateral case. (13372726)
1956
47
Horizontal excision of tarsus; in the correction of ectropion luxurians. (13180647)
1954
48
Ptosis with elephantiasis and ectropion. (15425615)
1950
49
SUBCUTANEOUS SPLITTING OF THE LID IN THE OPERATIVE TREATMENT OF SENILE ECTROPION*. (18170136)
1945
50
Case of Ichthyosis of the Skin, with Ectropion. (19985195)
1926

Genetic Variations for Ectropion

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Expression for genes affiliated with Ectropion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ectropion

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Pathways for genes affiliated with Ectropion

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Compounds for genes affiliated with Ectropion

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28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Ectropion according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1heme28 11 2411.5CYP4V2, CYP4F22, UROS

GO Terms for genes affiliated with Ectropion

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16Gene Ontology
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Biological processes related to Ectropion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinizationGO:0314249.7TGM1, ABCA12
2positive regulation of triglyceride catabolic processGO:0108989.6AADAC, ABHD5

Molecular functions related to Ectropion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:0044979.8CYP4V2, CYP4F22
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:0167059.7CYP4V2, CYP4F22
3triglyceride lipase activityGO:0048069.6AADAC, ABHD5

Products for genes affiliated with Ectropion

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Ectropion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet