MCID: ECT005
MIFTS: 39

Ectropion malady

Categories: Eye diseases

Aliases & Classifications for Ectropion

Aliases & Descriptions for Ectropion:

Name: Ectropion 12 29 52 42 14
Ectropion of Eyelid 12
Everted Margin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1570
ICD9CM 35 374.1 374.10
MeSH 42 D004483
UMLS 69 C0013592

Summaries for Ectropion

MalaCards based summary : Ectropion, also known as ectropion of eyelid, is related to ichthyosis, autosomal recessive 4b and cicatricial ectropion. An important gene associated with Ectropion is TGM1 (Transglutaminase 1). The drugs Ethanol and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 71 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

Related Diseases for Ectropion

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
id Related Disease Score Top Affiliating Genes
1 ichthyosis, autosomal recessive 4b 31.7 ABCA12 TGM1
2 cicatricial ectropion 12.0
3 congenital ectropion uveae 12.0
4 senile ectropion 12.0
5 mechanical ectropion 11.9
6 spastic ectropion 11.9
7 isolated congenital ectropion 11.9
8 barber-say syndrome 11.8
9 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 11.8
10 ichthyosis alopecia eclabion ectropion mental retardation 11.7
11 blepharocheilodontic syndrome 11.5
12 ichthyosis, congenital, autosomal recessive 1 10.8
13 neu-laxova syndrome1 10.8
14 ichthyosis, congenital, autosomal recessive 4a 10.8
15 jones hersh yusk syndrome 10.7
16 mandibulofacial dysostosis with macroblepharon and macrostomia 10.7
17 sezary's disease 10.7
18 ichthyosis, congenital, autosomal recessive 9 10.7
19 ichthyosis, congenital, autosomal recessive 2 10.7
20 ichthyosis, congenital, autosomal recessive 3 10.7
21 congenital ichthyosiform erythroderma 10.7
22 ichthyosis, congenital, autosomal recessive 6 10.7
23 ichthyosis, congenital, autosomal recessive 10 10.7
24 ichthyosis, congenital, autosomal recessive 5 10.7
25 neu-laxova syndrome 2 10.7
26 keratosis follicularis spinulosa decalvans, x-linked 10.7
27 ichthyosis, congenital, autosomal recessive 8 10.7
28 ichthyosis, congenital, autosomal recessive 11 10.7
29 ichthyosis, congenital, autosomal recessive 7 10.7
30 euryblepharon 10.3
31 entropion 10.3
32 ichthyosis 10.2
33 velocardiofacial syndrome 10.2 ABCA12 TGM1
34 amyotrophic lateral sclerosis 19 10.1 ABCA12 TGM1
35 cervicitis 10.1
36 dermatitis, atopic 2 10.1 ABCA12 TGM1
37 cataract 15, multiple types 10.0 DSG4 TGM1
38 tinea profunda 10.0 DNAAF3 DOCK8
39 preauricular tag, isolated, autosomal dominant, 1 10.0 ABCA12 TGM1
40 solitary bone cyst 10.0 ABCA12 DSG4 TGM1
41 burns 9.9
42 lagophthalmos 9.9
43 ptosis 9.9
44 facial paralysis 9.9
45 pyoderma gangrenosum 9.8
46 pyoderma 9.8
47 vaginitis 9.8
48 senile entropion 9.8
49 mucositis 9.8
50 ampulla of vater clear cell adenocarcinoma 9.7 ABCA12 DOCK8 KMT2D TGM1

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion

Symptoms & Phenotypes for Ectropion

MGI Mouse Phenotypes related to Ectropion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 ABCA12 DNAAF3 DSG4 KMT2D NF1 PSAT1
2 craniofacial MP:0005382 9.8 ABCA12 KMT2D NF1 PSAT1 TWIST2 UROS
3 homeostasis/metabolism MP:0005376 9.76 KMT2D NF1 PSAT1 TGM1 TWIST2 UROS
4 integument MP:0010771 9.43 ABCA12 DSG4 NF1 TGM1 TWIST2 UROS
5 respiratory system MP:0005388 9.02 ABCA12 DNAAF3 KMT2D NF1 TWIST2

Drugs & Therapeutics for Ectropion

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2
Fluorouracil Approved Early Phase 1 51-21-8 3385
3
acetic acid Approved, Nutraceutical 64-19-7 176
4 cadexomer iodine
5
Iodine 7553-56-2 807
6
Retinol acetate 127-47-9 10245972
7 Antimetabolites Early Phase 1
8 Antimetabolites, Antineoplastic Early Phase 1
9 Immunosuppressive Agents Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3
4 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
5 Lacrimal Drainage Resistance Study Completed NCT01766232
6 Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Recruiting NCT03150745
7 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Not yet recruiting NCT02705352 Early Phase 1
8 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Not yet recruiting NCT02638610

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

Genetic Tests for Ectropion

Genetic tests related to Ectropion:

id Genetic test Affiliating Genes
1 Ectropion 29

Anatomical Context for Ectropion

MalaCards organs/tissues related to Ectropion:

39
Skin, Eye, Cervix, Lung, Testes, Bone

Publications for Ectropion

Articles related to Ectropion:

(show top 50) (show all 436)
id Title Authors Year
1
Newly identified paired box 6 mutation of variant familial aniridia: Congenital iris ectropion with foveal hypoplasia. ( 28300742 )
2017
2
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. ( 27768224 )
2017
3
Is it safe to use N-acetylcysteineA in the treatment of bilateralA ectropion on collodion baby? ( 28083950 )
2017
4
Primary Horizontal Closure With Suspension Sutures for Infraorbital Defects to Achieve Aesthetically Superior Closure and Prevent Ectropion. ( 27224889 )
2016
5
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. ( 26859652 )
2016
6
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2016
7
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2016
8
Transposed Corrugator Supercilii Muscle-Tendon Unit Flap for Contralateral Paralytic Medial Ectropion Repair. ( 26987020 )
2016
9
Lipograft in cicatricial ectropion. ( 27842016 )
2016
10
Frangipane's Penitent's ectropion. ( 27986438 )
2016
11
Tarsal Strip Versus Tarsal Belt in Ectropion Correction: A Statistical Evaluation. ( 27755408 )
2016
12
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2016
13
The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion. ( 27785003 )
2016
14
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. ( 26674895 )
2016
15
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. ( 27191780 )
2016
16
Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis. ( 27974983 )
2016
17
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. ( 27529153 )
2016
18
Misdiagnosed Periocular Pyoderma Gangrenosum Requiring Ectropion Repair With Development of Second Lesion of Pyoderma Gangrenosum at Graft Site. ( 26934168 )
2016
19
Use of amniotic membrane graft in the surgical management of cicatricial ectropion associated with cetuximab therapy. ( 25576167 )
2015
20
Frontal osteomyelitis presenting as upper eyelid ectropion: A cautionary tale. ( 26155088 )
2015
21
Long-Term Outcome of Combined Lateral Tarsal Strip With Temporal Permanent Tarsorrhaphy for Correction of Paralytic Ectropion Caused By Facial Nerve Palsy. ( 26086924 )
2015
22
Superficial Temporal Artery Island Flap for Cicatricial Ectropion. ( 26079124 )
2015
23
Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. ( 26186347 )
2015
24
Post-Blepharoplasty Hematoma Caused Lower-Lid Ectropion and Early Correction. ( 26468816 )
2015
25
The hybrid approach for reconstruction of severely destructed lower eyelids: combination of skin grafting, temporary tarsorrhaphy, and autologous fat grafting for cicatricial ectropion after injection of commercial grade silicone. ( 25569426 )
2015
26
Non-surgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid. ( 25639983 )
2015
27
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". ( 25945875 )
2015
28
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. ( 26164158 )
2015
29
Eyelid Necrosis and Secondary Cicatrical Ectropion Secondary to Levamisole-Associated Vasculitis. ( 26398243 )
2015
30
Modified auricular cartilage sling for paralytic ectropion. ( 25840523 )
2015
31
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. ( 25794020 )
2015
32
Punctal function in lacrimal drainage: the 'pipette sign' and functional ectropion. ( 25944074 )
2015
33
Eyelid Finger Manipulation in the Treatment of Over-Corrected Blepharoptosis and Post-Blepharoplasty Ectropion-Retraction. ( 25724054 )
2015
34
Reply: Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. ( 26186346 )
2015
35
Lower lid ectropion in hypohidrotic ectodermal dysplasia. ( 25802783 )
2015
36
Cicatricial ectropion secondary to psoriatic arthritis. ( 25810938 )
2015
37
Erlotinib induced ectropion following papulopustular rash. ( 26236413 )
2015
38
Ectropion in a case of collodion baby. ( 25489540 )
2014
39
The tarsal belt procedure for the correction of ectropion: description and outcome in 42 cases. ( 24993105 )
2014
40
Caruncular Fixation in Medial Canthal Tendon Repair: The Minimally Invasive Purse String Suture for Tendinous Laxity and Medial Ectropion. ( 24911533 )
2014
41
Paralytic ectropion treatment with lateral periosteal flap canthoplasty and introduction of the ectropion severity score. ( 25289344 )
2014
42
Re: "inverting sutures for tarsal ectropion (the leicester modified suture technique)". ( 24614559 )
2014
43
Age-matched, case-controlled comparison of clinical indicators for development of entropion and ectropion. ( 24734167 )
2014
44
Inverting Sutures With Systemic Retinoids and Lubrication Can Correct Ectropion in Ichthyosis. ( 25216196 )
2014
45
Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures. ( 25025386 )
2014
46
A simple method for the treatment of cicatricial ectropion and eyelid contraction in patients with periocular burn: Vertical V-Y advancement of the eyelid. ( 25306087 )
2014
47
Management of Cicatricial Ectropion Secondary to Pyoderma Gangrenosum. ( 24410585 )
2014
48
Eyelid lifting for ectropion and scleral show in facial palsy disease. ( 25572490 )
2014
49
Reply re: "inverting sutures for tarsal ectropion (The Leicester modified suture technique)". ( 24614560 )
2014
50
Cervical Ectropion and Intra-Uterine Contraceptive Device (IUCD): a five-year retrospective study of family planning clients of a tertiary health institution in Lagos Nigeria. ( 25539789 )
2014

Variations for Ectropion

Expression for Ectropion

Search GEO for disease gene expression data for Ectropion.

Pathways for Ectropion

GO Terms for Ectropion

Cellular components related to Ectropion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 DSG4 TGM1

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 ABCA12 DSG4 TGM1
2 keratinocyte differentiation GO:0030216 8.8 ABCA12 DSG4 TGM1

Sources for Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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