Aliases & Classifications for Ectropion

MalaCards integrated aliases for Ectropion:

Name: Ectropion 12 29 52 42 14
Ectropion of Eyelid 12
Everted Margin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1570
ICD9CM 35 374.1 374.10
MeSH 42 D004483
UMLS 69 C0013592

Summaries for Ectropion

MalaCards based summary : Ectropion, also known as ectropion of eyelid, is related to ichthyosis, congenital, autosomal recessive 4b and neu-laxova syndrome 1. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Glycine, serine and threonine metabolism and Amino acid synthesis and interconversion (transamination). The drugs Fluorouracil and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 72 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

Related Diseases for Ectropion

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
id Related Disease Score Top Affiliating Genes
1 ichthyosis, congenital, autosomal recessive 4b 31.8 ABCA12 TGM1
2 neu-laxova syndrome 1 31.7 PHGDH PSAT1
3 ichthyosis alopecia eclabion ectropion mental retardation 12.0
4 congenital ectropion uveae 12.0
5 cicatricial ectropion 11.9
6 senile ectropion 11.9
7 mechanical ectropion 11.9
8 spastic ectropion 11.9
9 isolated congenital ectropion 11.9
10 barber-say syndrome 11.8
11 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 11.8
12 blepharocheilodontic syndrome 11.6
13 ichthyosis, congenital, autosomal recessive 1 10.8
14 ichthyosis, congenital, autosomal recessive 4a 10.8
15 mandibulofacial dysostosis with macroblepharon and macrostomia 10.7
16 jones hersh yusk syndrome 10.7
17 neu-laxova syndrome 2 10.7
18 corneal dystrophy, posterior polymorphous, 1 10.7
19 ichthyosis, congenital, autosomal recessive 8 10.7
20 keratosis follicularis spinulosa decalvans, x-linked 10.7
21 gorlin-chaudhry-moss syndrome 10.7
22 ichthyosis, congenital, autosomal recessive 11 10.7
23 ichthyosis, congenital, autosomal recessive 7 10.7
24 ichthyosis, congenital, autosomal recessive 9 10.7
25 ichthyosis, congenital, autosomal recessive 2 10.7
26 sezary's disease 10.7
27 ichthyosis, congenital, autosomal recessive 3 10.7
28 ichthyosis, congenital, autosomal recessive 6 10.7
29 ichthyosis, congenital, autosomal recessive 10 10.7
30 ichthyosis, congenital, autosomal recessive 5 10.7
31 congenital ichthyosiform erythroderma 10.7
32 autism x-linked 4 10.3 MBTPS2 SAT1
33 euryblepharon 10.3
34 kidney cancer, childhood 10.3 MBTPS2 SAT1
35 coenurosis 10.3 PHGDH PSAT1
36 entropion 10.3
37 dysentery 10.3 MBTPS2 SAT1
38 chronic cholangitis 10.3 MBTPS2 SAT1
39 ichthyosis 10.2
40 amyotrophic lateral sclerosis 19 10.2 ABCA12 TGM1
41 deafness, autosomal dominant 53 10.2 ABCA12 TGM1
42 vitamin b12 deficiency 10.1 PHGDH PSAT1
43 cervical clear cell adenocarcinoma 10.1 ABCA12 TGM1
44 ichthyosis vulgaris 10.1 ABCA12 TGM1
45 acute hemorrhagic encephalitis 10.1 NF1 PHGDH
46 cervicitis 10.1
47 otosclerosis 4 10.0 MBTPS2 SAT1
48 richter's syndrome 9.9 ABCA12 TGM1
49 congenital structural myopathy 9.9 MBTPS2 SAT1
50 ptosis 9.9

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion

Symptoms & Phenotypes for Ectropion

MGI Mouse Phenotypes related to Ectropion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 ABCA12 NF1 PAX6 PHGDH PSAT1 SAT1
2 homeostasis/metabolism MP:0005376 9.76 SAT1 TGM1 TWIST2 ABCA12 NF1 PAX6
3 craniofacial MP:0005382 9.72 ABCA12 NF1 PAX6 PSAT1 TWIST2
4 integument MP:0010771 9.35 ABCA12 NF1 PAX6 TGM1 TWIST2
5 neoplasm MP:0002006 8.92 NF1 PAX6 PHGDH SAT1

Drugs & Therapeutics for Ectropion

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2 Immunosuppressive Agents Phase 2
3 Antimetabolites Phase 2
4 Antimetabolites, Antineoplastic Phase 2
5
Ethanol Approved 64-17-5 702
6
acetic acid Approved, Nutraceutical 64-19-7 176
7
Iodine Investigational 7553-56-2 807
8 cadexomer iodine
9
Retinol acetate 127-47-9 10245972

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
4 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
5 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
6 Lacrimal Drainage Resistance Study Completed NCT01766232
7 Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Recruiting NCT03150745
8 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Not yet recruiting NCT02638610

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

Genetic Tests for Ectropion

Genetic tests related to Ectropion:

id Genetic test Affiliating Genes
1 Ectropion 29

Anatomical Context for Ectropion

MalaCards organs/tissues related to Ectropion:

39
Skin, Eye, Cervix, Testes, Lung, Bone

Publications for Ectropion

Articles related to Ectropion:

(show top 50) (show all 448)
id Title Authors Year
1
Newly identified paired box 6 mutation of variant familial aniridia: Congenital iris ectropion with foveal hypoplasia. ( 28300742 )
2017
2
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. ( 27768224 )
2017
3
Upper eyelid ectropion repair. ( 28928260 )
2017
4
Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis. ( 28460993 )
2017
5
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. ( 28380102 )
2017
6
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. ( 28815772 )
2017
7
Ectropion ( 28722958 )
2017
8
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. ( 28658179 )
2017
9
Punctal Ectropion repair using the Raus-Garito clamp. ( 28853961 )
2017
10
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. ( 28746254 )
2017
11
Is it safe to use N-acetylcysteineA in the treatment of bilateralA ectropion on collodion baby? ( 28083950 )
2017
12
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. ( 28314226 )
2017
13
Congenital Ectropion Uveae with Glaucoma: A Case Report. ( 28764212 )
2017
14
Congenital upper eyelids ectropion in Down's syndrome. ( 28194320 )
2017
15
A young Botswana patient with congenital iris ectropion uvea. ( 28154731 )
2016
16
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. ( 27191780 )
2016
17
Lipograft in cicatricial ectropion. ( 27842016 )
2016
18
Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis. ( 27974983 )
2016
19
Tarsal Strip Versus Tarsal Belt in Ectropion Correction: A Statistical Evaluation. ( 27755408 )
2016
20
Misdiagnosed Periocular Pyoderma Gangrenosum Requiring Ectropion Repair With Development of Second Lesion of Pyoderma Gangrenosum at Graft Site. ( 26934168 )
2016
21
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2016
22
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. ( 26674895 )
2016
23
Transposed Corrugator Supercilii Muscle-Tendon Unit Flap for Contralateral Paralytic Medial Ectropion Repair. ( 26987020 )
2016
24
The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion. ( 27785003 )
2016
25
Frangipane's Penitent's ectropion. ( 27986438 )
2016
26
Primary Horizontal Closure With Suspension Sutures for Infraorbital Defects to Achieve Aesthetically Superior Closure and Prevent Ectropion. ( 27224889 )
2016
27
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2016
28
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. ( 27529153 )
2016
29
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. ( 26859652 )
2016
30
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2016
31
Punctal function in lacrimal drainage: the 'pipette sign' and functional ectropion. ( 25944074 )
2015
32
Superficial Temporal Artery Island Flap for Cicatricial Ectropion. ( 26079124 )
2015
33
Cicatricial ectropion secondary to psoriatic arthritis. ( 25810938 )
2015
34
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". ( 25945875 )
2015
35
Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. ( 26186347 )
2015
36
Long-Term Outcome of Combined Lateral Tarsal Strip With Temporal Permanent Tarsorrhaphy for Correction of Paralytic Ectropion Caused By Facial Nerve Palsy. ( 26086924 )
2015
37
Eyelid Necrosis and Secondary Cicatrical Ectropion Secondary to Levamisole-Associated Vasculitis. ( 26398243 )
2015
38
Lower lid ectropion in hypohidrotic ectodermal dysplasia. ( 25802783 )
2015
39
The hybrid approach for reconstruction of severely destructed lower eyelids: combination of skin grafting, temporary tarsorrhaphy, and autologous fat grafting for cicatricial ectropion after injection of commercial grade silicone. ( 25569426 )
2015
40
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. ( 26164158 )
2015
41
Modified auricular cartilage sling for paralytic ectropion. ( 25840523 )
2015
42
Non-surgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid. ( 25639983 )
2015
43
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. ( 25794020 )
2015
44
Use of amniotic membrane graft in the surgical management of cicatricial ectropion associated with cetuximab therapy. ( 25576167 )
2015
45
Eyelid Finger Manipulation in the Treatment of Over-Corrected Blepharoptosis and Post-Blepharoplasty Ectropion-Retraction. ( 25724054 )
2015
46
Frontal osteomyelitis presenting as upper eyelid ectropion: A cautionary tale. ( 26155088 )
2015
47
Post-Blepharoplasty Hematoma Caused Lower-Lid Ectropion and Early Correction. ( 26468816 )
2015
48
Reply: Eyelid Finger Manipulation in the Treatment of Overcorrected Blepharoptosis and Postblepharoplasty Ectropion-Retraction. ( 26186346 )
2015
49
Erlotinib induced ectropion following papulopustular rash. ( 26236413 )
2015
50
Marginal ectropion induced by conjunctival ingrowth after levator resection surgery. ( 24952020 )
2014

Variations for Ectropion

Expression for Ectropion

Search GEO for disease gene expression data for Ectropion.

Pathways for Ectropion

Pathways related to Ectropion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.67 PHGDH PSAT1
2
Show member pathways
10.24 PHGDH PSAT1

GO Terms for Ectropion

Cellular components related to Ectropion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 ABCA12 NF1 PAX6 PHGDH PSAT1 SAT1

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.5 NF1 PAX6 PHGDH
2 neural tube development GO:0021915 9.4 NF1 PHGDH
3 cellular amino acid biosynthetic process GO:0008652 9.37 PHGDH PSAT1
4 regulation of gene expression GO:0010468 9.33 NF1 PAX6 PHGDH
5 spinal cord development GO:0021510 9.26 NF1 PHGDH
6 keratinocyte differentiation GO:0030216 9.13 ABCA12 PAX6 TGM1
7 L-serine biosynthetic process GO:0006564 8.62 PHGDH PSAT1

Sources for Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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