Eczema malady

MedlinePlus: Eczema is a term for several different types of skin swelling. eczema is also called dermatitis. it is not dangerous, but most types cause red, swollen and itchy skin. factors that can cause eczema include other diseases, irritating substances, allergies and your genetic makeup. eczema is not contagious. the most common type of eczema is atopic dermatitis. it is an allergic condition that makes your skin dry and itchy. it is most common in babies and children. eczema is a chronic disease. you can prevent some types of eczema by avoiding irritants, stress, and the things you are allergic to.²³

MalaCards: Eczema is related to eczema herpeticum and atopy. An important gene associated with Eczema is IL4R (interleukin 4 receptor), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Tyrosine metabolism p.1 (dopamine). The drugs methdilazine and methdilazine hydrochloride and the compounds ivig and budesonide have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and monocytes, and related mouse phenotypes are craniofacial and respiratory system.

Wikipedia: Eczema or atopic dermatitis (from Greek ἔκζεμα ēkzema, \"to boil over\") is a form of...⁴⁴ more...

eczema 17 32 23 43

Diseases related to eczema by text searches and GeneDecks gene sharing:

(show top 50)    (show all 806)

id	Related Disease	Score	Top Affiliating Genes
1	eczema herpeticum	33.7	CDSN, FLG2, FLG, IL7R, IGHE, CASP14
2	atopy	32.0	MS4A2, IL4R, PLA2G7
3	asthma	31.6	IL13, CCL11, TNF, PLA2G7
4	food allergy	31.1	FOXP3, IL13, IL4, IL5, CCL11, IGES
5	wiskott-aldrich syndrome	29.7	WAS, WASL, BTK, CD40LG, ITK, FCER2
6	ichthyosis vulgaris	28.7	CDSN, FLG2, FLG, SPRR3, KRT14
7	epidermolysis bullosa pruriginosa	28.4	MMP1, FLG, IL31
8	epidermolysis bullosa	28.0	CD79A, CD151, MMP1, FLG, IL2RB, IL31
9	allergic rhinitis	28.0	SELE, VIP, IL13, IL4, IL5, IGES
10	hyper-ige syndrome	27.9	IGES, IGHE, DOCK8, STAT3
11	contact dermatitis	27.1	SELE, LCE3B, LCE3C, LBR, FLG, IL10
12	atopic dermatitis	26.5	SELE, VIP, CMA1, LGALS3, LBR, LALBA
13	urticaria	23.5	SELE, CMA1, MS4A2, CD79A, CD40LG, FCER1A
14	vaccinia	23.3	WAS, WASL, IL10, IL17A, IL18, IL2
15	mycosis fungoides	22.9	SELE, CD40LG, IL10, IL13, IL16, IL17A
16	dermatitis	22.0	BTK, SELE, VIP, CMA1, LGALS3, LCE3B
17	bronchial asthma	21.4	SELE, VIP, CMA1, MS4A2, MPO, CD79A
18	inflammatory bowel disease	21.3	SELE, VIP, MPO, CD14, MMP1, FOXP3
19	herpes simplex	21.2	LGALS3, LBR, CD79A, CD40LG, CD1D, IL10
20	blindness	19.3	SELE, VIP, RARA, MPO, CD79A, CD40LG
21	rhinitis	17.9	BTK, SELE, VIP, CMA1, MS4A2, MPO
22	epidermolytic hyperkeratosis	14.1	FLG, KRT14, KLK7, KLK8, DEFB4A
23	helminthiasis	14.0	IL13, IL5, IGHE, RNASE3
24	allergic bronchopulmonary aspergillosis	14.0	IL4, IL5, IGES, IGHE
25	extrinsic allergic alveolitis	14.0	CD14, FCER2, IL18, IGHE
26	intrinsic asthma	14.0	FCER2, IL4, IL5, CCL5, IGES, IGHE
27	netherton syndrome	14.0	CDSN, FLG, IGHE, SPINK5, KLK7, DSC1
28	paragonimiasis	14.0	IL5, CCL17, IGHE, RNASE3
29	allergic conjunctivitis	14.0	IL13, IL4, IL5, CCL11, IGHE, RNASE3
30	chronic sphenoidal sinusitis	14.0	IL13, IL4, IL5, CCL11, IGES, IGHE
31	egg allergy	13.9	IL4, IL5, IGHE
32	eosinophilic gastroenteritis	13.9	IL5, CCL11, IGES, IGHE, RNASE3, PRG2
33	kimura disease	13.9	IL13, IL4, IL5, CCL11, CCR3, IGES
34	eosinophilic pneumonia	13.9	IL13, IL5, CCL11, CCL17, CCL5, IGHE
35	autoimmune enteropathy	13.9	FOXP3, IL17A, CSN1S1
36	chronic eosinophilic pneumonia	13.8	IL5, CCL11, RNASE3
37	respiratory failure	13.8	CMA1, IL13, CCL11, CCL17, CCR3, CCL5
38	giant papillary conjunctivitis	13.8	IL5, CCL11, RNASE3
39	b cell deficiency	13.8	BTK, CD79A, IL4, IL5, IGHE
40	toxocariasis	13.8	CD40LG, IGHE, RNASE3
41	immunodeficiency with hyper igm type 1	13.7	BTK, CD79A, CD40LG, IL4, IGHE
42	chronic rhinitis	13.7	MPO, CALCA, RNASE3, EPX
43	pthirus pubis infestation	13.7	FCER2, IL5, CCL11, IGHE, NGF, EPX
44	exanthem	13.7	IL5, CCL27, CCL11
45	corneal ulcer	13.7	CCL11, CCR3, NGF, PRG2
46	pulmonary eosinophilia	13.7	IL13, IL4, IL5, CCL11, CCL17, CCR3
47	cryptosporidiosis	13.7	CD40LG, IL4, CCL11, CCL5
48	endogenous depression	13.7	MAOA, CRH, PF4
49	dancing eyes-dancing feet syndrome	13.7	TNFSF13, TNFSF13B, POMC
50	immunodeficiency with hyper igm	13.7	CD79A, CD40LG, IGHE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 methdilazine, methdilazine hydrochloride, zinc (as zinc oxide)

MalaCards organs/tissues related to eczema:

²²

MGI Mouse Phenotypes related to eczema:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.1	FCER1G, IL17A, FLG, GATA3, FOXP3, LBR
2	respiratory system phenotype	MP:0005388	10.0	CLEC7A, CD14, CD1D, CALCA, TP63, CRH
3	renal/urinary system phenotype	MP:0005367	9.6	MAOB, FADS2, AQP3, IL5RA, FCER1G, CD151
4	endocrine/exocrine gland phenotype	MP:0005379	9.4	TLR2, CD40LG, IL2, IL2RB, CDSN, LALBA
5	digestive/alimentary phenotype	MP:0005381	8.5	AQP3, FADS1, FADS2, CCL2, CCR5, IFNG
6	other phenotype	MP:0005395	8.4	IL2, CRH, TLR2, STAT3, IL13, CD40LG
7	integument phenotype	MP:0010771	8.4	PAH, BTK, TGM3, STAT6, CSN1S1, POMC
8	liver/biliary system phenotype	MP:0005370	8.3	IL6, CD1D, IL12RB2, IL2, CCR5, IFNG
9	skeleton phenotype	MP:0005390	8.2	STAT3, GATA3, TP63, PLAU, IL6, CALCA
10	normal phenotype	MP:0002873	7.9	WASL, SELE, DSC1, TPT1, CRH, NR3C1
11	nervous system phenotype	MP:0003631	7.7	MAOB, LBR, LGALS3, PAH, WASL, TLR4
12	mortality/aging	MP:0010768	7.0	FLG, FOXP3, CD151, CD1D, CD14, CDSN
13	adipose tissue phenotype	MP:0005375	6.4	NR3C1, TNF, CCL2, IL6, LBR, CD14
14	reproductive system phenotype	MP:0005389	6.1	CCL2, IL13, IL4, IL6, IFNG, FADS2
15	growth/size phenotype	MP:0005378	6.1	IL13, STAT6, ADRB2, ADIPOQ, GATA3, IL18
16	vision/eye phenotype	MP:0005391	5.3	IL18, IL10, FOXP3, LBR, PAH, RARA
17	muscle phenotype	MP:0005369	5.1	ADIPOQ, ADRB2, MPO, IL10, IL18, IL6
18	tumorigenesis	MP:0002006	4.1	ADIPOQ, TLR4, TIMP1, STAT3, STAT6, SOD2
19	homeostasis/metabolism phenotype	MP:0005376	3.9	GATA3, ADIPOQ, FCER1A, CCL2, CCR5, CCR3
20	behavior/neurological phenotype	MP:0005386	3.7	TLR2, AQP3, VIP, CCL2, CCR5, IFNG
21	cardiovascular system phenotype	MP:0005385	2.5	MPO, CDSN, LGALS3, ICAM1, CLEC4E, RARA
22	immune system phenotype	MP:0005387	INF	CD151, ITK, FLG, IL6, AQP3, FADS1
23	hematopoietic system phenotype	MP:0005397	INF	IGHE, ITK, CD151, CD1D, LGALS3, CLEC4E
24	cellular phenotype	MP:0005384	INF	STAT3, TGFB2, DSC1, TLR9, TLR4, TLR2

Articles related to eczema:

(show top 50)    (show all 177)

id	Title	Authors	Year	Affiliating Genes
1	IL13 genetic polymorphisms, smoking, and eczema in wo men: a case-control study in Japan. (22013915)	Miyake Y.... Arakawa M.	2011	IL13
2	Association screening in the Epidermal Differentiatio n Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. (21490620)	Marenholz I.... Lee Y.A.	2011	SPRR3
3	The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patient s. (21765951)	Chen Y.... Karlsson M.C.	2011	TNFSF13B, TNFSF13, TNFSF12
4	Human atopic dermatitis complicated by eczema herpeti cum is associated with abnormalities in IFN-I^ response. (21458658)	Leung D.Y.... Barnes K.C.	2011	IFNG
5	Filaggrin null mutations increase the risk and persis tence of hand eczema in subjects with atopic dermatitis: results from a general population study. (20426775)	Thyssen J.P.... Johansen J.D.	2010	FLG
6	Case-Control Study of Eczema Associated with IL13 Gen etic Polymorphisms in Japanese Children. (20975284)	Miyake Y.... Hirota Y.	2010	IL13
7	Japanese-specific filaggrin gene mutations in Japanes e patients suffering from atopic eczema and asthma. (20686498)	Osawa R.... Shimizu H.	2010	FLG
8	Filaggrin loss-of-function mutations are associated w ith early-onset eczema, eczema severity and transepidermal water loss at 3 mont hs of age. (21137118)	Flohr C.... Lack G.	2010	FLG
9	Filaggrin null-mutations may be associated with a dis tinct subtype of atopic hand eczema. (20814636)	Thyssen J.P.... MennAc T.	2010	FLG
10	Meta-analysis of filaggrin polymorphisms in eczema an d asthma: robust risk factors in atopic disease. (19501237)	RodrA-guez E.... Weidinger S.	2009	FLG
11	Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. (19133922)	LiedAcn A.... D'Amato M.	2009	CRNN
12	Filaggrin mutations may confer susceptibility to chro nic hand eczema characterized by combined allergic and irritant contact dermati tis. (19538184)	Molin S.... Prinz J.C.	2009	FLG
13	Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. (18331416)	Nagel G.... Weiland S.K.	2009	ADIPOQ
14	Enhanced expression of the antimicrobial peptide LL-3 7 in lesional skin of adults with atopic eczema. (19309368)	Ballardini N.... Agerberth B.	2009	CAMP
15	Viewing a humorous film decreases IgE production by seminal B cells from patients with atopic eczema. (19154860)	Kimata H.	2009	LGALS3, IGHE
16	FLG mutation p.Lys4021X in the C-terminal imperfect f ilaggrin repeat in Japanese patients with atopic eczema. (19663875)	Nemoto-Hasebe I.... Shimizu H.	2009	FLG
17	Filaggrin mutations that confer risk of atopic dermat itis confer greater risk for eczema herpeticum. (19733298)	Gao P.S.... Leung D.Y.	2009	FLG
18	Use of Phadiatop Infant in diagnosis of specific sensitization in young children with wheeze or eczema. (18221462)	Lau S.... Wahn U.	2008	IGHE
19	Eczema and X-linked agammaglobulinaemia. (18076688)	Hunter H.L.... Edgar J.D.	2008	BTK
20	Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk. (18774391)	Weidinger S.... Irvine A.D.	2008	KLK7, SPINK5, FLG
21	Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. (18578563)	Bisgaard H.... Custovic A.	2008	FLG
22	Filaggrin mutations, atopic eczema, hay fever, and asthma in children. (18396323)	Weidinger S.... Kabesch M.	2008	FLG
23	Structural and functional alterations in the beta2-adrenoceptor are caused by a point mutation in patients with atopic eczema. (17845212)	Schallreuter K.U.... Wood J.M.	2007	ADRB2
24	Atopic eczema: genetics or environment? (18247450)	Wuthrich B.... Schmid-Grendelmeier P.	2007	FLG
25	Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. (17121586)	Negoro T.... Tobe T.	2006	STAT6, IL4, IL10
26	Increased expression of RANTES, CCR3 and CCR5 in the lesional skin of patients with atopic eczema. (16449815)	Kato Y.... Kawana S.	2006	CCR5, CCR3, CCL5
27	Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure. (16403101)	KrAomer U.... Behrendt H.	2006	IGHE
28	Comparison of fecal microflora in children with atopic eczema/dermatitis syndrome according to IgE sensitization to food. (16618364)	Kendler M.... Jecht E.	2006	CSN1S1, IGHE
29	Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. (16159638)	Graves P.E.... Martinez F.D.	2005	ITK, HAVCR1, HAVCR2
30	Candida albicans-specific lymphoproliferative and cytokine (IL-4 and IFN-gamma) responses in atopic eczema dermatitis syndrome. Evidence of CD4/CD8 and CD3/CD16+CD56 ratio elevations in vitro. (15946244)	Kosonen J.... Savolainen J.	2005	IL4, IFNG
31	Role of immunoglobulin E sensitization in eczema, pre viously referred to as atopic dermatitis. (20476939)	Johansson S.G.... Williams H.	2005	IGHE
32	Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. (15693914)	Viljanen M.... Savilahti E.	2005	CD79A, RNASE3
33	IgE-binding components of cultured human keratinocytes in atopic eczema/dermatitis syndrome and their crossreactivity with Malassezia furfur. (14763930)	Kortekangas-Savolainen O.... Savolainen J.	2004	IGHE
34	Elevated levels of IgG and IgG4 to Malassezia allergens in atopic eczema patients with IgE reactivity to Malassezia. (15345907)	Johansson C.... Scheynius A.	2004	IGHE
35	Enhanced platelet activation in patients with atopic eczema/dermatitis syndrome. (16134004)	Kasperska-Zaj C A.... Rogala B.	2004	PPBP
36	Suckling reduces allergic skin responses and plasma levels of neuropeptide and neurotrophin in lactating women with atopic eczema/dermatitis syndrome. (14707470)	Kimata H.	2003	NTF3, VIP
37	Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema. (12709813)	JAorvikallio A.... Naukkarinen A.	2003	CALCA
38	Orange-induced skin lesions in patients with atopic eczema: evidence for a non-IgE-mediated mechanism. (12636022)	Brockow K.... Ring J.	2003	RNASE3
39	Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency. (14651577)	Murphy L.A.... Atherton D.J.	2003	TPMT
40	The relationship among markers of allergy, asthma, allergic rhinitis, and eczema in Costa Rica. (12000480)	CeledA^n J.C.... Weiss S.T.	2002	IGHE, IGES
41	An interaction between the IL-4Ralpha gene and infection is associated with atopic eczema in young children. (12100043)	Callard R.E.... Henderson J.	2002	IL4R
42	Starvation reduces allergen-induced skin wheal responses and plasma substance P and vasoactive intestinal peptide in patients with atopic eczema/dermatitis syndrome. (12406028)	Kimata H.	2002	VIP
43	Lack of association between atopic eczema and the genetic variants of interleukin-4 and the interleukin-4 receptor alpha chain gene: heterogeneity of genetic backgrounds on immunoglobulin E production in atopic eczema patients. (11678851)	Tanaka K.... Montgomery D.S.	2001	IL4, IL4R, IGHE
44	Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease. (10336597)	Tanaka K.... Furuyama J.	1999	CMA1
45	Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema. (9452885)	Schallreuter K.U.... BA1ttner G.	1997	MAOA, PNMT
46	Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes. (7748751)	Latchman Y.... Brostoff J.	1995	FCER2
47	Lesional expression of interferon-gamma in atopic eczema. (7905045)	Grewe M.... Krutmann J.	1994	IFNG
48	Immunopathogenesis of atopic eczema (8079299)	Bjerke J.R.	1994	IGHE
49	Recent developments in the treatment of childhood ato pic eczema. (2066937)	David T.J.	1991	IFNG
50	Atopic eczema, Langerhans cells and allergy. (1937874)	Ring J.... Przybilla B.	1991	PRG2, TPT1, RNASE3

Genes related to eczema according to GeneCards:

(show top 50)    (show all 126)

id	Symbol	Description	Score	GeneCards Section Context
1	IL4R	interleukin 4 receptor	11.1	Summaries, Publications
2	COL6A5	collagen, type VI, alpha 5	11.0	Summaries, Publications
3	WAS	Wiskott-Aldrich syndrome	11.0	Aliases & Descriptions, Orthologs
4	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
5	FLG	filaggrin	11.0	Publications
6	CAMP	cathelicidin antimicrobial peptide	11.0	Publications
7	IL31	interleukin 31	11.0	Publications
8	CRLF2	cytokine receptor-like factor 2	11.0	Publications
9	KLK12	kallikrein-related peptidase 12	11.0
10	CMA1	chymase 1, mast cell	11.0	Publications, Functions
11	KLK8	kallikrein-related peptidase 8	11.0
12	TSLP	thymic stromal lymphopoietin	11.0	Publications
13	IGES	immunoglobulin E concentration, serum	11.0	Publications
14	AQP3	aquaporin 3 (Gill blood group)	11.0	Publications
15	CCL27	chemokine (C-C motif) ligand 27	11.0
16	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
17	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
18	SPN	sialophorin	11.0
19	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
20	IL7R	interleukin 7 receptor	11.0	Publications
21	IL4	interleukin 4	11.0	Publications
22	KRT14	keratin 14	11.0
23	LBR	lamin B receptor	11.0	Publications
24	IL13	interleukin 13	11.0	Publications
25	FOXP3	forkhead box P3	11.0
26	CD14	CD14 molecule	11.0	Publications
27	LCE3B	late cornified envelope 3B	10.9	Publications
28	LCE3C	late cornified envelope 3C	10.9	Publications
29	CRNN	cornulin	10.9	Publications
30	SPRR3	small proline-rich protein 3	10.9	Publications
31	TNFSF12	tumor necrosis factor (ligand) superfamily, member 12	10.9	Publications
32	CLEC4E	C-type lectin domain family 4, member E	10.9	Publications
33	FLG2	filaggrin family member 2	10.9
34	HRNR	hornerin	10.9	Publications
35	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	10.9	Publications
36	FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	10.9	Publications
37	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	10.9	Publications
38	CDSN	corneodesmosin	10.9
39	GGCT	gamma-glutamylcyclotransferase	10.9
40	TSPAN32	tetraspanin 32	10.9	Publications
41	HAVCR2	hepatitis A virus cellular receptor 2	10.9	Publications
42	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	10.9	Publications
43	PNMT	phenylethanolamine N-methyltransferase	10.9	Publications
44	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	10.9	Publications
45	KLK7	kallikrein-related peptidase 7	10.9	Publications
46	CLEC7A	C-type lectin domain family 7, member A	10.9	Publications
47	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	10.9	Publications
48	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	10.9	Publications
49	CD53	CD53 molecule	10.9	Publications
50	DEFB4A	defensin, beta 4A	10.9	Publications

Pathways related to eczema according to GeneDecks:

(show top 50)    (show all 107)

id	Pathway	Score	Top Affiliating Genes
1	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.1	GATA3, STAT6, TGFB2, IL4R, IL4, FCER1A
2	Tyrosine metabolism p.1 (dopamine)10	10.1	PAH, ABP1, PNMT, MAOA, AOC3, MAOB
3	RAR-Gamma-RXR-Alpha Degradation36	9.9	TNFSF13B, TNFSF13, CCL5, CCL18, CCL17, CCL11
4	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	IL13, TGFB2, IL6, IL5, IL4R, IL4
5	PGC1Alpha Pathway36	9.6	IL18, IL16, IL13, IL10RA, BTK, IL2
6	NFAT Signaling and Lymphocyte Interactions36	9.3	IL5, IL4, IL2RB, IL2, IL16, IL13
7	JNK Pathway36	9.3	IL2RB, PPBP, NTF3, CCL11, IL7R, IL6
8	Asthma20	9.3	EPX, CD40LG, MS4A2, FCER1A, FCER1G, PRG2
9	Chemokine signaling pathway20	9.3	PPBP, CCL5, CCL18, CCR3, CCL17, CCR5
10	Hematopoietic cell lineage20	9.0	IL4, FCER2, CD1D, CD14, IL4R, IL7R
11	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	IL17A, TLR4, STAT3, TLR9, IFNG, IL6
12	Regulation of eIF4 and p70S6K36	9.0	IL13, IL16, IL18, CCL11, CCL18, BTK
13	Intestinal immune network for IgA production20	8.9	IL5, IL6, TNFSF13, TNFSF13B, IL2, CD40LG
14	MSP-RON Signaling36	8.9	KLK8, TLR4, TLR2, KLK7, KLK12, TNF
15	IL-6 Pathway36	8.8	BTK, IL10, IL16, IL18, IL4, IL5
16	Jak-STAT signaling pathway20	8.8	IL10, IL10RA, IL12RB2, IL13, IL2, IL2RB
17	Endothelin-1 Signaling Pathway36	8.8	BTK, IL10, IL13, IL16, IL18, IL2
18	Transendothelial Migration of Leukocytes36	8.8	CCR3, CCL18, CCL5, ICAM1, PF4, PRG2
19	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	FOXP3, IL10, IL2, IL2RB, TNF, TGFB2
20	Measles20	8.4	IL6, IL2, IL2RB, IL4, STAT3, TLR9
21	ERK Signaling36	8.4	TNFSF12, TNFSF13, TNFSF13B, PPBP, PF4, TIMP1
22	THC Differentiation Pathway36	8.3	IL2, TNF, IFNG, IL4, IL18, IL12RB2
23	Tuberculosis20	8.1	CLEC4E, CAMP, FCER1G, CLEC7A, TLR4, TGFB2
24	Cytokine Network36	8.0	TNF, IL13, IL16, IL18, IL2, IL4
25	Glucocorticoid Receptor Signaling36	8.0	NR3C1, TNFSF13B, CCL5, CCL18, CCL17, CCL11
26	African trypanosomiasis20	8.0	TLR9, SELE, IL18, IL10, TNF, ICAM1
27	SOCS Pathway36	7.9	STAT3, TNFSF13B, CCL5, CCL18, CCL17, CCL11
28	IL-10 Pathway36	7.8	IL10, IL10RA, IL6, TNF, STAT3, TLR4
29	Molecular Mechanisms of Cancer36	7.8	PRG2, TGFB2, TIMP1, PF4, PPBP, NTF3
30	TGF-Beta Pathway36	7.8	CCL18, CCL17, CCL11, CCL2, CCL27, IL7R
31	Immune response MIF-mediated glucocorticoid regulation10	7.5	MMP1, IL2, IL6, NR3C1, TNF, IFNG
32	Immune response_MIF-mediated glucocorticoid regulation41	7.5	MMP1, IL2, IL6, IFNG, ICAM1, TNF
33	Th1 Differentiation37	7.5	IL10, IL12RB2, IL2, IL18, IFNG, TNF
34	Rheumatoid arthritis20	7.2	ICAM1, IFNG, CCL5, CCL2, IL6, IL18
35	all-trans-Retinoic Acid Signaling in Brain36	7.2	CCL18, CCL5, TNF, TNFSF12, TNFSF13, TNFSF13B
36	JAK-STAT Pathway36	7.2	STAT3, TGFB2, TIMP1, PPBP, NTF3, TNFSF13B
37	PEDF Induced Signaling36	7.2	SOD2, CCL27, IL6, IL5, IL4, IL2
38	Chagas disease (American trypanosomiasis)20	7.2	IL2, TLR4, TLR2, TLR9, CCL2, IFNG
39	MIF Regulation of Innate Immune Cells36	7.2	BTK, CD14, IL10, IL13, IL16, IL18
40	Malaria20	7.0	IL6, IL18, IL10, CD40LG, SELE, CCL2
41	MIF Mediated Glucocorticoid Regulation36	7.0	IL18, CCL27, TLR4, PF4, IL6, IL5
42	PAK Pathway36	7.0	CCL18, CCL17, CCL11, CCL2, CCL27, IL6
43	Akt Signaling36	6.9	NTF3, IL16, IL18, IL2, IL2RB, IL4
44	Rho Family GTPases36	6.9	IL6, WASL, IL5, IL4, IL2, IL18
45	MAPK Family Pathway36	6.5	IL4, BTK, IL2RB, IL2, IL18, IL16
46	STAT3 Pathway36	6.1	STAT3, PF4, TNFSF13B, TNFSF13, IL7R, IL6
47	Cytokine-cytokine receptor interaction20	6.1	TGFB2, CCL18, CCR3, CCL17, CCR5, CCL11
48	p38 Signaling36	6.0	CCL27, IL13, IL12RB2, IL10RA, IL10, BTK
49	Antioxidant Action of Vitamin-C36	6.0	IL4, NTF3, PPBP, PLA2G7, PF4, TIMP1
50	Tec Kinases Signaling36	5.2	CCL2, CCL5, IL4R, IL4, IL2RB, IL2

Compounds related to eczema according to GeneDecks:

(show top 50)    (show all 388)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.6	BTK, CCR5, PLA2G7
2	budesonide32 42 9 9	13.1	IL5RA, CCL11, IGHE, NR3C1, RNASE3, POMC
3	endotoxin32	9.7	CD14, IL18, IL2RB, CCL11, CAMP, PLA2G7
4	latex32	9.6	WAS, WASL, LGALS3, CD14, FLG, IL18
5	salbutamol32 34 9 18 9	13.6	VIP, CD79A, FCER2, IL10, IL13, IL18
6	salmeterol32 42 9 9	12.5	IL13, IL2, IL4, IL5, CCL11, CCL5
7	methacholine32 9 9	10.9	VIP, MPO, CD79A, CD14, IL13, IL17A
8	epinephrine32 9 18 9	11.8	SELE, VIP, PAH, LBR, CD79A, MMP1
9	n acetylcysteine32	8.7	SELE, CD79A, MMP1, IL18, IL2RB, CCL11
10	rolipram32 42	9.6	SELE, IL10, IL13, IL4, IL5, CCL11
11	heparin32 9 18 9	11.5	CMA1, LGALS3, LBR, LALBA, MPO, CD79A
12	aspartate32	8.4	VIP, RARA, PAH, LALBA, CD14, CD40LG
13	h2o232	8.3	VIP, PAH, LGALS3, LBR, MPO, CD79A
14	pge232	8.2	SELE, VIP, CD14, MMP1, FOXP3, FCER2
15	fmlp32	8.0	MPO, CD14, FCER2, IL13, IL5, CCL2
16	cysteine32	8.0	BTK, RARA, CMA1, PAH, LGALS3, LBR
17	polysaccharide32	7.9	SELE, LGALS3, LALBA, CD79A, CD14, CD40LG
18	estrogen32	7.9	VIP, RARA, LGALS3, LALBA, MMP1, IL18
19	butyrate32	7.8	RARA, LGALS3, MPO, CD14, IL18, IL5
20	groalpha32	7.8	SELE, IL10, IL13, IL17A, IL18, CCL2
21	glutamine32	7.7	VIP, PAH, LGALS3, LALBA, CD14, FCER2
22	calcium32 9 18 9	10.7	WAS, BTK, VIP, RARA, CMA1, PAH
23	aspirin32 34 18	9.6	SELE, LGALS3, CD79A, CD40LG, MMP1, IL13
24	lipoteichoic acid32	7.5	SELE, CD14, IL10, IL18, IL6, CCL2
25	cholesterol32 9 18 9	10.4	SELE, CMA1, LBR, CD14, IL18, IL2RB
26	tarc32	7.3	IL10, IL13, IL18, IL4, IL4R, IL5
27	phosphatidylinositol32	7.2	WAS, WASL, BTK, RARA, LGALS3, CD14
28	pentoxifylline32 9 9	9.2	LBR, MPO, CD14, MMP1, IL10, IL13
29	infliximab32 9 9	9.1	SELE, LBR, MMP1, FLG, IL10, IL17A
30	tacrolimus32 34 9 9	10.1	CD79A, IL10, IL13, IL16, IL17A, IL18
31	paraffin32	7.1	RARA, CMA1, LGALS3, MPO, CD79A, CD14
32	gm-csf32	7.0	CD14, IL10, IL13, IL18, IL2, IL4
33	tgf beta132	7.0	RARA, MMP1, FOXP3, IL10, IL13, IL18
34	creatinine32	6.8	SELE, MPO, CD79A, CD14, CD40LG, MMP1
35	ccl332	6.7	IL10, IL13, IL18, IL6, CCL27, CCL2
36	pdtc32	6.4	SELE, MMP1, FCER2, IL18, IL4, IL6
37	norepinephrine32 9 18 9	9.4	SELE, VIP, PAH, LBR, CD79A, CD14
38	fibrinogen32	6.3	BTK, SELE, LGALS3, LALBA, CD79A, CD14
39	vitamin d32	6.3	RARA, PAH, LGALS3, LBR, CD79A, CD14
40	ly29400232	6.2	SELE, RARA, IL10, IL13, IL17A, IL18
41	il 1032	6.2	IL10, IL10RA, IL13, IL18, IL2, IL2RB
42	herbimycin a32 42	7.0	SELE, CD14, CD40LG, MMP1, FCER2, IL2
43	lipid32	6.0	WAS, WASL, BTK, SELE, RARA, LGALS3
44	alanine32	5.7	SELE, VIP, RARA, PAH, LGALS3, LALBA
45	rantes32	5.3	SELE, VIP, LBR, CD14, CD40LG, MMP1
46	cyclosporin a32 42	5.6	VIP, LBR, CD79A, CD14, CD40LG, ITK
47	actinomycin d32	4.5	SELE, RARA, CD40LG, IL13, IL17A, IL2
48	retinoic acid32 42 18	6.2	RARA, LGALS3, LBR, MPO, CD79A, CD14
49	histamine32 18	4.5	BTK, SELE, VIP, CMA1, LBR, LALBA
50	dexamethasone32 42 34 9 9	6.6	VIP, RARA, CLEC7A, LBR, CD79A, CD14

Cellular components related to eczema according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	9.0	TNF, CD14, CD79A, MS4A2, SELE, BTK
2	cell surface	GO:009986	8.6	CD14, RARA, CD1D, TGFB2, CD53, AOC3
3	external side of plasma membrane	GO:009897	8.1	CCR5, IL4, IL2RB, IL17A, IL13, FCER2
4	integral to plasma membrane	GO:005887	7.4	CCR3, CCR5, FADS2, IL4R, IL2RB, TLR4
5	plasma membrane	GO:005886	6.0	FCER1G, IL10RA, IL16, IL2RB, IL5RA, LGALS3
6	extracellular region	GO:005576	5.8	VIP, CCL2, CCL17, CCL5, CCL11, IFNG
7	extracellular space	GO:005615	4.1	IL2, ICAM1, CALCA, TPT1, TNF, TNFSF12

Biological processes related to eczema according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:008544	10.7	CDSN, WAS, KLK7, KRT14, CASP14, NTF3
2	positive regulation of interleukin-10 production	GO:032733	10.4	FCER1G, TLR9, TLR4, IL4, CD40LG
3	keratinization	GO:031424	10.4	SPRR3, LCE3C, LCE3B, TGM3, HRNR
4	type 2 immune response	GO:042092	10.2	IL10, IL18, IL4
5	negative regulation of interferon-gamma production	GO:032689	10.1	TLR4, IL10, GATA3, RARA, FOXP3
6	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	CD40LG, IL10, IL4, TLR4, IFNG
7	positive regulation of interleukin-12 production	GO:032735	10.1	TLR9, TLR2, TLR4, IFNG, CD40LG
8	positive regulation of tumor necrosis factor production	GO:032760	10.1	IFNG, IL18, FCER1G, CD14, NOD1, PF4
9	response to radiation	GO:009314	10.0	IL18, TGFB2, NGF, NR3C1, CCL11
10	defense response to bacterium	GO:042742	10.0	TLR4, PPBP, RNASE3, NOD1, SPN, CAMP
11	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.0	TLR4, TLR2, CCL2, FCER2, TLR9
12	positive regulation of interleukin-13 production	GO:032736	10.0	RARA, GATA3, IL4
13	positive regulation of T cell proliferation	GO:042102	10.0	CD1D, CCL5, IFNG, SPN, IL4, IL6
14	positive regulation of B cell proliferation	GO:030890	9.9	CD40LG, TLR4, IL5, IL4, IL2, IL13
15	positive regulation of interleukin-8 production	GO:032757	9.8	IL18, TLR2, TLR4, TLR9, ADIPOQ, CALCA
16	positive regulation of inflammatory response	GO:050729	9.7	IL18, TLR9, TLR4, TLR2, PLA2G7, IL2
17	leukocyte cell-cell adhesion	GO:007159	9.7	CD40LG, CCL5, CALCA, SELE, ICAM1
18	negative regulation of tumor necrosis factor production	GO:032720	9.6	RARA, IL10, POMC, TLR4, ADIPOQ
19	chemotaxis	GO:006935	9.6	CCR5, CCL11, CCL2, CCL27, IL4, SPN
20	positive regulation of osteoclast differentiation	GO:045672	9.5	TNF, IL17A, CCL5, IFNG
21	positive regulation of cytokine secretion	GO:050715	9.5	TLR2, TNF, IL10, CD14, CLEC4E
22	cellular response to tumor necrosis factor	GO:071356	9.4	ICAM1, CCL5, IL18, CCL2, GATA3
23	negative regulation of growth of symbiont in host	GO:044130	9.4	TLR2, IL10, IFNG, CAMP, TNF
24	monocyte chemotaxis	GO:002548	9.4	IL6, CCL2, CCL5, CALCA
25	positive regulation of NF-kappaB import into nucleus	GO:042346	9.3	TLR2, TLR9, TLR4, TNF
26	negative regulation of interleukin-6 production	GO:032715	9.3	TNF, TLR4, TLR9, IL10
27	cell surface receptor signaling pathway	GO:007166	9.3	IL7R, IL12RB2, SPN, CCR5, CD14, ADRB2
28	cellular response to lipopolysaccharide	GO:071222	9.2	IFNG, IL10, CD14, CCL2, CCR5, ICAM1
29	immune response	GO:006955	9.2	PRG2, IL18, IL17A, IL16, IL13, CLEC4E
30	response to virus	GO:009615	9.2	FOXP3, IFNG, TPT1, TNF, GATA3, OAS2
31	defense response to Gram-positive bacterium	GO:050830	9.1	IL6, CAMP, TNF, NOD1, TLR2
32	lipopolysaccharide-mediated signaling pathway	GO:031663	9.1	CCL2, CCL5, TNF, TLR2, TLR4, IL18
33	positive regulation of nitric oxide biosynthetic process	GO:045429	9.0	TLR4, TLR2, TNF, ICAM1, IFNG
34	cell-cell signaling	GO:007267	9.0	FADS1, NTF3, IL2, IL18, IL17A, IL13
35	response to ethanol	GO:045471	9.0	STAT3, ADIPOQ, GATA3, IL13, TLR4, ICAM1
36	positive regulation of interleukin-6 production	GO:032755	8.9	IL6, TLR4, TLR2, NOD1, TNF, FCER1G
37	positive regulation of chemokine production	GO:032722	8.9	TLR9, TLR2, TNF, IL18, TLR4, IL6
38	response to activity	GO:014823	8.8	IL10, CCL2, CCL5, TNF, TLR4, NR3C1
39	humoral immune response	GO:006959	8.7	TNF, CCL2, IL6, GATA3, MS4A2, IFNG
40	positive regulation of interferon-gamma production	GO:032729	8.6	IL12RB2, IL18, IL2, TNF, TLR4, CD40LG
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.4	IL6, BTK, ICAM1, TNF, TLR2, NOD1
42	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.2	NGF, TNF, IL5, IL4, IL10, IL6
43	signal transduction	GO:007165	8.1	CCL2, STAT6, POMC, GATA3, IL13, CCL11
44	positive regulation of cell proliferation	GO:008284	8.1	TGFB2, VIP, RARA, IL12RB2, ADRB2, TIMP1
45	cytokine-mediated signaling pathway	GO:019221	7.9	CCL2, IL2RB, IL12RB2, IL6, IL5, STAT3
46	response to glucocorticoid stimulus	GO:051384	7.9	ADIPOQ, NGF, TNF, IL10, IL6, CCL2
47	response to drug	GO:042493	7.7	TGFB2, STAT3, IL4, ABP1, NGF, IL10
48	anti-apoptosis	GO:006916	7.7	CCL2, IL10, NR3C1, MPO, NGF, CD40LG
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.0	TP63, TLR4, TLR2, NTF3, TNF, RARA
50	inflammatory response	GO:006954	6.6	TLR9, NGF, NOD1, TNF, CALCA, CCL5

Molecular functions related to eczema according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	IgE binding	GO:019863	10.5	FCER2, FCER1G, FCER1A, MS4A2, LGALS3
2	primary amine oxidase activity	GO:008131	10.3	AOC3, MAOA, MAOB, ABP1
3	IgE receptor activity	GO:019767	10.1	FCER1G, MS4A2, FCER1A
4	chemokine activity	GO:008009	9.8	CCL11, CCL18, CCL5, CCL2, PPBP, PF4
5	tumor necrosis factor receptor binding	GO:005164	9.3	TNFSF13, TNFSF12, TNF, CD40LG, TNFSF13B
6	protein homodimerization activity	GO:042803	9.2	NOD1, ABP1, TGFB2, ADRB2, ADIPOQ, NR3C1
7	receptor binding	GO:005102	8.8	TGFB2, RARA, CALCA, POMC, CRH, NTF3
8	growth factor activity	GO:008083	8.4	TGFB2, NGF, PPBP, NTF3, IL6, IL4
9	cytokine activity	GO:005125	7.1	IL2, IL16, IL17A, IL18, TSLP, IL31