MCID: ECZ002
MIFTS: 46

Eczema Herpeticum malady

Categories: Infectious diseases, Skin diseases, Eye diseases

Aliases & Classifications for Eczema Herpeticum

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Aliases & Descriptions for Eczema Herpeticum:

Name: Eczema Herpeticum 11 49 13 67
Herpes Simplex Eyelid Dermatitis 11 67
Kaposi Varicelliform Eruption 38 67
Herpes Simplex Dermatitis 11 67
 
Herpes Simplex Virus Eyelid Dermatitis 11
Herpes Simplex Dermatitis of Eyelid 11
Herpes Simplex Virus Dermatitis 11

Classifications:



External Ids:

Disease Ontology11 DOID:9123
ICD1029 B00.0
ICD9CM31 054.0, 054.41
MeSH38 D007617
NCIt44 C35620

Summaries for Eczema Herpeticum

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Disease Ontology:11 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including watery blisters, fever and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways are Dendritic Cells Developmental Lineage Pathway and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:70 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

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Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis10.5
2atopic dermatitis10.5
3herpes simplex10.3
4nut allergy10.3FLG, IFNG
5orbit alveolar rhabdomyosarcoma10.3FLG, IFNG
6inflammatory linear verrucous epidermal nevus10.2IFNG, IFNGR1
7wissler's syndrome10.2FLG, IFNG
8churg-strauss syndrome10.2FLG, IFNG
9goat milk allergy10.2IFNG, IFNGR1
10sarcoid meningitis10.2IFNG, TSLP
11atrial tachyarrhythmia with short pr interval10.2IFNG, IFNGR1
12askin's tumor10.2IFNG, IFNGR1
13hypospadias10.1IFNG, IFNGR1
14exophthalmos10.1IFNG, TSLP
15cutaneous porphyria10.1IFNG, IFNGR1
16lung sarcoma10.1FLG, IFNG
17blind hypotensive eye10.1IFNG, TSLP
18pemphigus10.1
19pleomorphic lipoma10.1IFNG, IFNGR1
20tertiary neurosyphilis10.0IDO1, IFNG
21calcifying epithelial odontogenic tumor10.0IDO1, IFNG
22multiple system atrophy, cerebellar type10.0IDO1, IFNG
23keratosis10.0IFNG, IFNGR1
24inner ear disease10.0IFNG, IRF3
25psychologic dyspareunia10.0IDO1, IFNG
26darier disease10.0
27pemphigus vulgaris10.0
28hepatic angiomyolipoma10.0FLG, IFNG, TSLP
29atopy9.9FLG, IFNG, TSLP
30dyskeratosis congenita9.9FLG, IFNG, TSLP
31mixed lacrimal gland cancer9.9IFNG, IFNGR1
32hypertensive encephalopathy9.9IFNG, TSLP
33taylor's syndrome9.9IFNG, IRF3
34lethal midline granuloma9.9IFNG, IFNGR1
35ichthyosis vulgaris9.8
36hailey-hailey disease9.8
37mycosis fungoides9.8
38burns9.8
39cataract9.8
40tinea cruris9.8
41perinephritis9.8
42femoral neuropathy9.8
43folliculitis9.8
44neuropathy9.8
45genital herpes9.8
46smallpox9.8
47meningitis9.8
48fasciitis9.8
49neonatal herpes9.8
50pneumococcal meningitis9.8

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Symptoms for Eczema Herpeticum

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Symptoms:

 11
  • watery blisters
  • fever
  • swelling of the lymph nodes

Drugs & Therapeutics for Eczema Herpeticum

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Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Formaldehydeapproved, vet_approvedEarly Phase 18450-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalin
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
2methicillin155
3VaccinesEarly Phase 16428
4Anti-Bacterial Agents10884
5interferons2137
6Antiviral Agents9732
7Interferon-gamma145
8Anti-Infective Agents21402

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic DermatitisCompletedNCT00515047
2Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic DermatitisCompletedNCT00438022
3Interferon Responses in Eczema HerpeticumCompletedNCT01429311
4The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA)CompletedNCT00822276
5ADRN Influenza Vaccine PilotCompletedNCT01518478Early Phase 1
6Atopic Dermatitis Research Network (ADRN) Influenza Vaccine StudyCompletedNCT01737710
7Immune Response to Varicella Vaccination in Children With Atopic DermatitisCompletedNCT00406081
8ADRN Barrier/Immunoprofiling Exploratory Pilot StudyCompletedNCT02115399
9Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and PsoriasisCompletedNCT00407979
10Role of Antimicrobial Peptides in Host Defense Against Vaccinia VirusCompletedNCT00407069
11Registry for the Atopic Dermatitis Research NetworkRecruitingNCT01494142

Search NIH Clinical Center for Eczema Herpeticum


Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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MalaCards organs/tissues related to Eczema Herpeticum:

35
Skin, Lymph node, Colon, T cells, Testes, Bone, Breast

FMA organs/tissues related to Eczema Herpeticum:

17
Skin

Animal Models for Eczema Herpeticum or affiliated genes

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MGI Mouse Phenotypes related to Eczema Herpeticum:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IDO1, IFNG, IFNGR1, IRF2, IRF7, TSLP
2MP:00053876.7IDO1, IFNG, IFNGR1, IRF2, IRF3, IRF7

Publications for Eczema Herpeticum

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Articles related to Eczema Herpeticum:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Validation of database search strategies for the epidemiological study of eczema herpeticum. (26822010)
2016
2
Relationship Between the Presence of Eczema Herpeticum and the Significance of Clinical and Laboratory Tests in Korean Children With Atopic Dermatitis. (27713812)
2016
3
A child presenting with primary gingivostomatitis and eczema herpeticum. (26864720)
2016
4
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. (26198597)
2015
5
A corneal dendritic lesion with a skin eruption: eczema herpeticum, an important differential diagnosis. (25636633)
2015
6
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. (26343451)
2015
7
Eczema Herpeticum in a Wrestler. (24714395)
2014
8
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. (24379126)
2014
9
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. (23600999)
2013
10
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? (23387866)
2013
11
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. (22994962)
2013
12
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. (22575249)
2012
13
Eczema herpeticum: a medical emergency. (23242894)
2012
14
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. (22113474)
2012
15
The clinical spectrum and therapeutic challenge of eczema herpeticum. (21261703)
2011
16
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)
2010
17
Localized eczema herpeticum with unilateral ocular involvement. (20976420)
2010
18
Eczema herpeticum and clinical criteria for investigating smallpox. (19624930)
2009
19
Monomorphic rash on the neck. Eczema herpeticum . (19817343)
2009
20
A case of eczema herpeticum with hailey-hailey disease. (20523813)
2009
21
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
22
Images in emergency medicine. Eczema herpeticum. (18565383)
2008
23
Eczema herpeticum in pregnancy and neonatal herpes infection. (18669762)
2008
24
Eczema herpeticum in a patient with atopicdermatitis treated with topical tacrolimus. (16185024)
2005
25
Eczema herpeticum localized to area of tinea cruris. (14739507)
2004
26
Eczema herpeticum during treatment of atopic dermatitis with 0.1% tacrolimus ointment. (11096198)
2000
27
Eczema herpeticum in children with atopic dermatitis. (10910542)
1999
28
Dermacase. Eczema herpeticum. (7920046)
1994
29
Eczema herpeticum induced by sun exposure. (1634302)
1992
30
Treatment of ocular disease in eczema herpeticum. (2118723)
1990
31
A rapidly progressive papulovesicular eruption. Eczema herpeticum/Kaposi's varicelliform eruption. (2684026)
1989
32
Severe eczema herpeticum is associated with prolonged depression of cell-mediated immunity to herpes simplex virus. (2545414)
1989
33
Eczema herpeticum. Clinical and laboratory features. (2835199)
1988
34
Treatment of eczema herpeticum with systemic acyclovir. (3977349)
1985
35
Eczema herpeticum in a patient with Darier's disease during treatment with etretinate. (4078062)
1985
36
Oral acyclovir in eczema herpeticum. (6421367)
1984
37
Severe atopic eczema, recurrent pneumococcal meningitis and recurrent eczema herpeticum. (6481746)
1984
38
Treatment of eczema herpeticum with acyclovir. (6849557)
1983
39
Eczema herpeticum in a man of 68. (7117645)
1982
40
Eczema herpeticum. (591662)
1977
41
Eczema herpeticum. Treatment with methylene blue and light. (170870)
1975
42
Eczema vaccinatum and eczema herpeticum in Darier disease. (4121405)
1973
43
Eczema herpeticum and pregnancy. (4347263)
1973
44
Recurrent eczema herpeticum associated with ichthyosis vulgaris. (4114690)
1972
45
Visceral involvement by herpes simplex virus in eczema herpeticum. (4300208)
1968
46
Eczema herpeticum, primary and recurrent. (4159394)
1966
47
KAPOSI'S SYNDROME: A CASE OF ECZEMA HERPETICUM COMPLICATED BY VARICELLA DURING CONVALESCENCE; REVIEW OF CURRENT OPINIONS. (14261914)
1965
48
Treatment of eczema herpeticum with gamma globulin. (13468788)
1957
49
Kaposi's varicelliform eruption (eczema herpeticum) with typical and atypical visceral necrosis. (13243173)
1955
50
An unusual epidemic of Kaposi's varicelliform eruption (eczema herpeticum). (13189825)
1954

Variations for Eczema Herpeticum

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Expression for genes affiliated with Eczema Herpeticum

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Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

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Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IRF2
29.5IFNG, TSLP
39.5IFNG, IFNGR1
4
Show member pathways
9.5IFNG, IFNGR1
59.3IDO1, IFNG
6
Show member pathways
9.1IRF3, IRF7
79.1IFNG, IFNGR1, IRF2
8
Show member pathways
9.0IFNG, IFNGR1, IRF3
9
Show member pathways
8.8IRF2, IRF3, IRF7
10
Show member pathways
8.8IRF2, IRF3, IRF7
118.8IRF2, IRF3, IRF7
12
Show member pathways
8.2IFNG, IRF2, IRF3, IRF7
13
Show member pathways
8.2IFNG, IFNGR1, IRF3, IRF7
14
Show member pathways
8.2IFNG, IFNGR1, IRF3, IRF7
15
Show member pathways
7.8IFNG, IFNGR1, IRF2, IRF3, IRF7
167.6IDO1, IFNG, IRF2, IRF3, IRF7

GO Terms for genes affiliated with Eczema Herpeticum

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Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of interferon-gamma-mediated signaling pathwayGO:006033410.0IFNG, IFNGR1
2positive regulation of interleukin-12 productionGO:00327359.8IDO1, IFNG
3type I interferon biosynthetic processGO:00453519.8IRF3, IRF7
4MDA-5 signaling pathwayGO:00395309.8IRF3, IRF7
5positive regulation of type I interferon-mediated signaling pathwayGO:00603409.7IRF3, IRF7
6TRIF-dependent toll-like receptor signaling pathwayGO:00356669.6IRF3, IRF7
7positive regulation of interferon-alpha productionGO:00327279.5IRF3, IRF7
8positive regulation of interferon-beta productionGO:00327289.5IRF3, IRF7
9positive regulation of type I interferon productionGO:00324819.4IRF3, IRF7
10type I interferon signaling pathwayGO:00603379.3IRF2, IRF3, IRF7
11response to virusGO:00096159.0IFNG, IFNGR1, IRF7
12interferon-gamma-mediated signaling pathwayGO:00603338.3IFNG, IFNGR1, IRF2, IRF3, IRF7
13negative regulation of transcription from RNA polymerase II promoterGO:00001228.2IFNG, IRF2, IRF3, IRF7

Sources for Eczema Herpeticum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet