MCID: ECZ002
MIFTS: 45

Eczema Herpeticum malady

Infectious, Eye categories

Summaries for Eczema Herpeticum

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in human herpesvirus 1 or human herpesvirus 2. the infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to atopic dermatitis and pemphigus, and has symptoms including fever, watery blisters and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is TSLP (thymic stromal lymphopoietin), and among its related pathways are TSLP Signaling Pathway and MSP-RON Signaling. The compounds ionomycin and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are integument and immune system.

Wikipedia:64 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Aliases & Classifications for Eczema Herpeticum

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Eye


Aliases & Descriptions:

eczema herpeticum 8 10 45 61
herpes simplex eyelid dermatitis 8 61
herpes simplex dermatitis 8 61
herpes simplex virus eyelid dermatitis 8
herpes simplex dermatitis of eyelid 8
herpes simplex virus dermatitis 8


External Ids:

Disease Ontology8 DOID:9123
ICD9CM27 054.41
ICD1025 B00.0

Related Diseases for Eczema Herpeticum

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis31.1CAMP, IFNG, FLG, IGHE, CDSN, TSLP
2pemphigus30.6DSC1
3ichthyosis vulgaris30.3FLG, FLG2
4pemphigus vulgaris10.4
5genital herpes10.2
6folliculitis10.2
7hailey-hailey disease10.2
8infectious mononucleosis10.2
9tinea cruris10.2
10femoral neuropathy10.2
11mycosis fungoides10.2
12smallpox10.2
13neonatal herpes10.2
14mental retardation10.2
15pneumococcal meningitis10.2
16omenn syndrome10.0IGHE
17eosinophilic esophagitis10.0TSLP
18sinusitis10.0IGHE
19rhinitis10.0IGHE
20strongyloidiasis10.0IGHE
21mumps10.0IRF2
22pulmonary eosinophilia10.0IGHE
23lichen planus10.0FLG
24contact dermatitis10.0FLG
25cholesteatoma10.0FLG
26candidiasis10.0IFNG
27keratosis10.0FLG
28hyper ige syndrome10.0IGHE, IFNG
29tetanus10.0IFNG
30congenital ichthyosiform erythroderma10.0FLG
31hepatitis c10.0IL7R, IFNG
32gamma chain deficiency10.0TSLP, IL7R
33nonepidermolytic palmoplantar keratoderma10.0FLG, KLK8
34hepatitis b10.0IFNG
35atopy10.0IFNG, FLG, IGHE, TSLP
36allergic rhinitis10.0IFNG, FLG, IGHE, TSLP
37netherton syndrome10.0DSC1, IGHE, CDSN, TSLP
38severe combined immunodeficiency10.0IL7R, IFNG
39leukemia10.0IL7R, CRLF2, IRF2, IFNG
40allergic asthma10.0IFNG, CRLF2, FLG, IGHE, TSLP
41viral infectious disease10.0TSLP, IL7R, IRF2, IFNG
42asthma10.0CAMP, IFNG, FLG, IGHE, TSLP
43dermatitis10.0IFNG, FLG, DSC1, IGHE, TSLP
44psoriasis9.9KLK8, CASP14, CAMP, IFNG, IRF2, FLG
45skin disease9.9CAMP, IFNG, IRF2, FLG, DSC1, IGHE

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Clinical Features for Eczema Herpeticum

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • fever
  • watery blisters
  • swelling of the lymph nodes

Drugs & Therapeutics for Eczema Herpeticum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eczema Herpeticum

Drug clinical trials:

Search ClinicalTrials for Eczema Herpeticum

Search NIH Clinical Center for Eczema Herpeticum

Search CenterWatch for Eczema Herpeticum

Genetic Tests for Eczema Herpeticum

Anatomical Context for Eczema Herpeticum

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Eczema Herpeticum:

33
Skin, Lymph node, Bone marrow, Colon, Breast, T cells

FMA organs/tissues related to Eczema Herpeticum:

14
Skin

Animal Models for Eczema Herpeticum or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Eczema Herpeticum:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0TSLP
2MP:00053877.8IFNG, IRF2, FLG, DSC1, IGHE, CDSN

Publications for Eczema Herpeticum

Sources:
51PubMed
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Articles related to Eczema Herpeticum:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. (24379126)
2014
2
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. (23600999)
2013
3
Topical corticosteroids and hospital length of stay in children with eczema herpeticum. (23039248)
2013
4
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. (22994962)
2013
5
Why is eczema herpeticum unexpectedly rare? (23439082)
2013
6
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). (22908727)
2012
7
Eczema herpeticum. (22433376)
2012
8
Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum. (22110485)
2011
9
Eczema herpeticum: making the diagnosis in the emergency department. (18584994)
2011
10
Kaposi's varicelliform eruption (eczema herpeticum) in an infant. (20706828)
2010
11
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. (19541356)
2009
12
Monomorphic rash on the neck. Eczema herpeticum . (19817343)
2009
13
Kaposi varicelliform eruption (eczema herpeticum). (18700121)
2008
14
Images in emergency medicine. Eczema herpeticum. (18565383)
2008
15
Eczema herpeticum in a patient with atopicdermatitis treated with topical tacrolimus. (16185024)
2005
16
Photo Quiz. What is your diagnosis? Eczema herpeticum superinfection in a patient with pemphigus vulgaris. (15186043)
2004
17
Eczema herpeticum in two elderly patients. (17656983)
2002
18
Photo quiz. Eczema herpeticum. (11398758)
2001
19
Recurrent eczema herpeticum: an underrecognised condition. (11158702)
2001
20
Detection of Herpes simplex virus DNA in non-herpetic areas of patients with eczema herpeticum. (10773695)
2000
21
Virus characterization studies in eczema herpeticum. (9580819)
1998
22
Comparison of the association with eczema herpeticum in the two predominant genotypes of herpes simplex virus type 1. (8877767)
1996
23
Eczema herpeticum in pregnancy successfully treated with acyclovir. (7980319)
1994
24
Suspected transmission of eczema herpeticum in a thermal bath establishment. (7889977)
1994
25
Eczema herpeticum in association with familial benign chronic pemphigus. (8432925)
1993
26
Eczema herpeticum. Clinical and laboratory features. (2835199)
1988
27
Increasing incidence of eczema herpeticum: analysis of seventy-five cases. (3204177)
1988
28
Management of eczema herpeticum. (3372774)
1988
29
Eczema herpeticum in three siblings: clinical features and acyclovir treatment. (3546436)
1986
30
Acyclovir therapy for eczema herpeticum in infants. (4051523)
1985
31
Is eczema herpeticum associated with the use of hot tubs? (4011510)
1985
32
Eczema herpeticum in a patient with Darier's disease during treatment with etretinate. (4078062)
1985
33
Recurrent eczema herpeticum in an adult. (3910696)
1985
34
Oral acyclovir in eczema herpeticum. (6421367)
1984
35
Treatment of eczema herpeticum with acyclovir. (6849557)
1983
36
Treatment of eczema herpeticum with vidarabine. (7103530)
1982
37
Atopic dermatitis, eczema herpeticum, infectious mononucleosis, and depressed cell-mediated immunity. (204057)
1978
38
Eczema herpeticum caused by herpesvirus type 2. A case in a patient with Darier disease. (196558)
1977
39
A case of femoral neuropathy associated with eczema herpeticum. (55494)
1976
40
Editorial: Methylene blue for eczema herpeticum. (1173927)
1975
41
Eczema vaccinatum and eczema herpeticum in Darier disease. (4121405)
1973
42
Recurrent eczema herpeticum associated with ichthyosis vulgaris. (4114690)
1972
43
Eczema herpeticum: presenting as hand, foot and mouth syndrome. (4338452)
1972
44
Eczema herpeticum. (4309780)
1969
45
Visceral involvement by herpes simplex virus in eczema herpeticum. (4300208)
1968
46
KAPOSI'S SYNDROME: A CASE OF ECZEMA HERPETICUM COMPLICATED BY VARICELLA DURING CONVALESCENCE; REVIEW OF CURRENT OPINIONS. (14261914)
1965
47
RECURRENT ECZEMA HERPETICUM. WIDESPREAD CUTANEOUS HERPES SIMPLEX IN ATOPIC PATIENT WITHOUT ACTIVE ATOPIC DERMATITIS. (14164964)
1964
48
Eczema herpeticum (Kaposi's varicelliform eruption) in an adult. (13642883)
1959
49
Kaposi's varicelliform eruption (eczema herpeticum) treated with prednisone. (13567719)
1958
50
Treatment of eczema herpeticum with gamma globulin. (13468788)
1957

Genetic Variations for Eczema Herpeticum

Expression for genes affiliated with Eczema Herpeticum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 30KEGG
See all sources

Pathways related to Eczema Herpeticum according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TSLP, IL7R, CRLF2
29.5KLK12, KLK8, IFNG
3
Hide members
9.4OAS2, IL7R, IRF2, IFNG
49.3TSLP, IL7R, CRLF2, IFNG

Compounds for genes affiliated with Eczema Herpeticum

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Eczema Herpeticum according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ionomycin459.7IL7R, IFNG, CAMP
22,5-oligoadenylate459.6IFNG, IRF2, OAS2
3allergens459.4TSLP, IGHE, FLG, IFNG
4infliximab45 50 1111.4IGHE, FLG, IFNG
5tarc459.3IFNG, IGHE, TSLP
6retinoic acid45 248.9CASP14, CAMP, IFNG, IRF2, FLG, DSC1

GO Terms for genes affiliated with Eczema Herpeticum

Sources:
16Gene Ontology
See all sources

Cellular components related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.7CDSN, DSC1
2extracellular regionGO:0055768.2IL7R, CDSN, IGHE, CRLF2, IFNG, CAMP

Biological processes related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:0603339.6OAS2, IRF2, IFNG
2negative regulation of myelinationGO:0316429.4IFNG, KLK8
3keratinocyte differentiationGO:0302169.0TGM3, CDSN, FLG

Products for genes affiliated with Eczema Herpeticum

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eczema Herpeticum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet