MCID: ECZ002
MIFTS: 49

Eczema Herpeticum malady

Infectious diseases, Eye diseases categories

Summaries for Eczema Herpeticum

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in human herpesvirus 1 or human herpesvirus 2. the infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including swelling of the lymph nodes, fever and watery blisters. An important gene associated with Eczema Herpeticum is TSLP (thymic stromal lymphopoietin), and among its related pathways are TSLP Signaling Pathway and MSP-RON Signaling. The compounds ionomycin and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are integument and immune system.

Wikipedia:63 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Aliases & Classifications for Eczema Herpeticum

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Eye diseases


Aliases & Descriptions:

eczema herpeticum 8 10 44 60
herpes simplex eyelid dermatitis 8 60
herpes simplex dermatitis 8 60
herpes simplex virus eyelid dermatitis 8
herpes simplex dermatitis of eyelid 8
herpes simplex virus dermatitis 8


External Ids:

Disease Ontology8 DOID:9123
ICD9CM27 054.41
ICD1025 B00.0

Related Diseases for Eczema Herpeticum

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis31.1IFNG, FLG, DSC1, IGHE, TSLP
2atopic dermatitis31.1CAMP, IFNG, FLG, IGHE, CDSN, TSLP
3pemphigus30.6DSC1
4ichthyosis vulgaris30.2FLG, FLG2
5herpes simplex10.7
6genital herpes10.2
7perinephritis10.2
8folliculitis10.2
9hailey-hailey disease10.2
10infectious mononucleosis10.2
11tinea cruris10.2
12femoral neuropathy10.2
13mycosis fungoides10.2
14cataract10.2
15fasciitis10.2
16meningitis10.2
17neuropathy10.2
18smallpox10.2
19omenn syndrome10.0IGHE
20eosinophilic esophagitis10.0TSLP
21sinusitis10.0IGHE
22rhinitis10.0IGHE
23strongyloidiasis10.0IGHE
24mumps10.0IRF2
25pulmonary eosinophilia10.0IGHE
26lichen planus10.0FLG
27contact dermatitis10.0FLG
28cholesteatoma10.0FLG
29candidiasis10.0IFNG
30keratosis10.0FLG
31hyper ige syndrome10.0IGHE, IFNG
32tetanus10.0IFNG
33congenital ichthyosiform erythroderma10.0FLG
34hepatitis c10.0IL7R, IFNG
35gamma chain deficiency10.0TSLP, IL7R
36nonepidermolytic palmoplantar keratoderma10.0FLG, KLK8
37hepatitis b10.0IFNG
38atopy10.0IFNG, FLG, IGHE, TSLP
39allergic rhinitis10.0IFNG, FLG, IGHE, TSLP
40netherton syndrome10.0DSC1, IGHE, CDSN, TSLP
41severe combined immunodeficiency10.0IL7R, IFNG
42leukemia10.0IL7R, CRLF2, IRF2, IFNG
43allergic asthma10.0IFNG, CRLF2, FLG, IGHE, TSLP
44viral infectious disease10.0TSLP, IL7R, IRF2, IFNG
45asthma10.0CAMP, IFNG, FLG, IGHE, TSLP
46psoriasis9.9KLK8, CASP14, CAMP, IFNG, IRF2, FLG
47skin disease9.9CAMP, IFNG, IRF2, FLG, DSC1, IGHE

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Clinical Features for Eczema Herpeticum

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8Disease Ontology
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Symptoms:

8
  • swelling of the lymph nodes
  • fever
  • watery blisters

Drugs & Therapeutics for Eczema Herpeticum

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Eczema Herpeticum

Search NIH Clinical Center for Eczema Herpeticum

Search CenterWatch for Eczema Herpeticum

Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Eczema Herpeticum:

32
Skin, Lymph node, T cells, Breast, Colon, Bone, Bone marrow

FMA organs/tissues related to Eczema Herpeticum:

14
Skin

Animal Models for Eczema Herpeticum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eczema Herpeticum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0TSLP
2MP:00053877.8IFNG, IRF2, FLG, DSC1, IGHE, CDSN

Publications for Eczema Herpeticum

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50PubMed
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Articles related to Eczema Herpeticum:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? (23387866)
2013
2
Eczema herpeticum complicating topical 5-Fluorouracil therapy. (23010835)
2012
3
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. (22575249)
2012
4
Eczema herpeticum: a medical emergency. (23242894)
2012
5
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. (22084327)
2011
6
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. (21211653)
2011
7
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-I^ response. (21458658)
2011
8
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)
2010
9
Localized eczema herpeticum with unilateral ocular involvement. (20976420)
2010
10
Eczema herpeticum in a patient with terminal renal failure under narrow-band uvb therapy. (20606898)
2010
11
Eczema herpeticum and clinical criteria for investigating smallpox. (19624930)
2009
12
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. (19733298)
2009
13
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
14
Molecular pathogenesis and clinical implications of eczema herpeticum. (18620613)
2008
15
Eczema herpeticum in pregnancy and neonatal herpes infection. (18669762)
2008
16
Risk factors of atopic dermatitis patients for eczema herpeticum. (17170734)
2007
17
Cathelicidin deficiency predisposes to eczema herpeticum. (16630942)
2006
18
Eczema herpeticum complicating Parthenium dermatitis. (16036117)
2005
19
High frequency of detection of herpes simplex virus DNA in the oral cavity of patients with eczema herpeticum. (15316162)
2004
20
Eczema herpeticum localized to area of tinea cruris. (14739507)
2004
21
Close association of predominant genotype of herpes simplex virus type 1 with eczema herpeticum analyzed using restriction fragment length polymorphism of polymerase chain reaction. (12668262)
2003
22
Eczema herpeticum: a dermatologic emergency. (12430518)
2002
23
Painful skin erosions and fever in an infant. Eczema herpeticum. (11272689)
2001
24
Eczema herpeticum in children with atopic dermatitis. (10910542)
1999
25
Pathological case of the month. Eczema herpeticum. (10437768)
1999
26
Microbiology of infected eczema herpeticum. (9555806)
1998
27
Treatment of recurrent eczema herpeticum in pregnancy with acyclovir. (18476099)
1996
28
Dermacase. Eczema herpeticum. (7920046)
1994
29
Hand eczema herpeticum. (8261809)
1993
30
Eczema herpeticum induced by sun exposure. (1634302)
1992
31
Eczema herpeticum occurring in autografted skin. (2061459)
1991
32
Treatment of ocular disease in eczema herpeticum. (2118723)
1990
33
A rapidly progressive papulovesicular eruption. Eczema herpeticum/Kaposi's varicelliform eruption. (2684026)
1989
34
Death from eczema herpeticum in a child with severe eczema, mental retardation and cataracts. (2704016)
1989
35
Immune responses to herpes simplex virus in patients with facial herpes simplex and those with eczema herpeticum. (2840941)
1988
36
Eczema herpeticum: a potentially fatal disease. (3032327)
1987
37
Eczema herpeticum treated with oral acyclovir. (3771849)
1986
38
Eczema herpeticum of the child. An unusual manifestation of herpes simplex virus infection. (2996817)
1985
39
Severe atopic eczema, recurrent pneumococcal meningitis and recurrent eczema herpeticum. (6481746)
1984
40
Treatment with acyclovir of genital herpes simplex virus infection complicated by eczema herpeticum. (6744011)
1984
41
Eczema herpeticum in a man of 68. (7117645)
1982
42
Eczema herpeticum. (7100087)
1982
43
Eczema herpeticum. (6930073)
1980
44
Eczema herpeticum: atopic dermatitis complicated by primary herpetic gingivostomatitis. (292955)
1979
45
Eczema herpeticum. Treatment with methylene blue and light. (170870)
1975
46
Eczema herpeticum and pregnancy. (4347263)
1973
47
ECZEMA HERPETICUM AS COMPLICATION OF DARIER'S DISEASE. (14295511)
1965
48
Kaposi's varicelliform eruption (eczema herpeticum) with typical and atypical visceral necrosis. (13243173)
1955
49
Eczema herpeticum Kaposi's varicelliform eruption; report of three recurrent cases. (14349391)
1955
50
An unusual epidemic of Kaposi's varicelliform eruption (eczema herpeticum). (13189825)
1954

Genetic Variations for Eczema Herpeticum

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Expression for genes affiliated with Eczema Herpeticum

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

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37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG
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Pathways related to Eczema Herpeticum according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TSLP, IL7R, CRLF2
29.5KLK12, KLK8, IFNG
3
Hide members
9.4OAS2, IL7R, IRF2, IFNG
49.3TSLP, IL7R, CRLF2, IFNG

Compounds for genes affiliated with Eczema Herpeticum

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Eczema Herpeticum according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ionomycin449.7IL7R, IFNG, CAMP
22,5-oligoadenylate449.6IFNG, IRF2, OAS2
3allergens449.4TSLP, IGHE, FLG, IFNG
4infliximab44 49 1111.4IGHE, FLG, IFNG
5tarc449.3IFNG, IGHE, TSLP
6retinoic acid44 248.9CASP14, CAMP, IFNG, IRF2, FLG, DSC1

GO Terms for genes affiliated with Eczema Herpeticum

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16Gene Ontology
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Cellular components related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.7CDSN, DSC1
2extracellular regionGO:0055768.2IL7R, CDSN, IGHE, CRLF2, IFNG, CAMP

Biological processes related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:0603339.6OAS2, IRF2, IFNG
2negative regulation of myelinationGO:0316429.4IFNG, KLK8
3keratinocyte differentiationGO:0302169.0TGM3, CDSN, FLG

Products for genes affiliated with Eczema Herpeticum

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Sources for Eczema Herpeticum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet