MCID: ECZ002
MIFTS: 47

Eczema Herpeticum malady

Categories: Infectious diseases, Skin diseases, Eye diseases

Aliases & Classifications for Eczema Herpeticum

About this section

Aliases & Descriptions for Eczema Herpeticum:

Name: Eczema Herpeticum 11 50 13 68
Herpes Simplex Eyelid Dermatitis 11 68
Kaposi Varicelliform Eruption 39 68
Herpes Simplex Dermatitis 11 68
 
Herpes Simplex Virus Eyelid Dermatitis 11
Herpes Simplex Dermatitis of Eyelid 11
Herpes Simplex Virus Dermatitis 11

Classifications:



External Ids:

Disease Ontology11 DOID:9123
ICD1030 B00.0
ICD9CM32 054.0, 054.41
MeSH39 D007617
NCIt45 C35620

Summaries for Eczema Herpeticum

About this section
Disease Ontology:11 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including watery blisters, fever and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways are Dendritic Cells Developmental Lineage Pathway and Development and heterogeneity of the ILC family. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:71 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

About this section

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis10.5
2atopic dermatitis10.5
3herpes simplex10.3
4myofibroma10.1FLG, IFNG
5oral cavity cancer10.1FLG, IFNG
6intravascular papillary endothelial hyperplasia10.1IFNG, IFNGR1
7giant cell glioblastoma10.1IFNG, IFNGR1
8crustacean allergy10.1IFNG, IFNGR1
9heart conduction disease10.1IFNG, IRF2
10anal atresia, hypospadias, and penoscrotal inversion10.1IFNG, IFNGR1
11microcephaly10.1IFNG, IFNGR1
12isolated growth hormone deficiency10.1IFNG, IFNGR1
13pemphigus10.1
14albinism10.1IDO1, IFNG
15rift valley fever10.0IFNG, IFNGR1
16balkan nephropathy10.0FLG, IFNG
17tracheitis10.0IFNG, TSLP
18chronic thromboembolic pulmonary hypertension10.0IDO1, IFNG
19isolated klippel-feil syndrome10.0IDO1, IFNG
20paratyphoid fever10.0FLG, IFNG
21gangliosidosis gm210.0FLG, IFNG, TSLP
22hyperimmunoglobulin syndrome10.0IFNG, IRF3
23mental retardation, autosomal dominant 1810.0FLG, IFNG, TSLP
24epidermolysis bullosa10.0FLG, IFNG, TSLP
25darier disease10.0
26pemphigus vulgaris10.0
27liver inflammatory pseudotumor10.0IFNG, IFNGR1
28severe acute respiratory syndrome10.0IRF3, IRF7
29classic type lipoma9.9IFNG, IFNGR1
30spermatocytoma9.9IRF3, IRF7
31benign eccrine breast spiradenoma9.9IFNG, IFNGR1
32ichthyosis vulgaris9.8
33hailey-hailey disease9.8
34mycosis fungoides9.8
35burns9.8
36cataract9.8
37tinea cruris9.8
38ichthyosis9.8
39perinephritis9.8
40femoral neuropathy9.8
41folliculitis9.8
42neuropathy9.8
43genital herpes9.8
44smallpox9.8
45meningitis9.8
46fasciitis9.8
47neonatal herpes9.8
48pneumococcal meningitis9.8
49exophthalmos9.8IFNG, IRF3, IRF7
50eczematous dermatitis of eyelid9.8IFNG, IRF3, IRF7

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Symptoms & Phenotypes for Eczema Herpeticum

About this section

Symptoms:

 11
  • watery blisters
  • fever
  • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IDO1, IFNG, IFNGR1, IRF2, IRF7, TSLP
2MP:00053876.7IDO1, IFNG, IFNGR1, IRF2, IRF3, IRF7

Drugs & Therapeutics for Eczema Herpeticum

About this section

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Formaldehydeapproved, vet_approvedEarly Phase 19350-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalin
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
2methicillin162
3VaccinesEarly Phase 16611
4Anti-Bacterial Agents11226
5interferons2175
6Antiviral Agents9967
7Interferon-gamma152
8Anti-Infective Agents22062

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic DermatitisCompletedNCT00515047
2Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic DermatitisCompletedNCT00438022
3Interferon Responses in Eczema HerpeticumCompletedNCT01429311
4The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA)CompletedNCT00822276
5Atopic Dermatitis Research Network (ADRN) Influenza Vaccine PilotCompletedNCT01518478Early Phase 1
6Atopic Dermatitis Research Network (ADRN) Influenza Vaccine StudyCompletedNCT01737710
7Immune Response to Varicella Vaccination in Children With Atopic DermatitisCompletedNCT00406081
8ADRN Barrier/Immunoprofiling Exploratory Pilot StudyCompletedNCT02115399
9Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and PsoriasisCompletedNCT00407979
10Role of Antimicrobial Peptides in Host Defense Against Vaccinia VirusCompletedNCT00407069
11Etiology of Eczema Herpeticum (EH)RecruitingNCT03038932
12Registry for the Atopic Dermatitis Research NetworkRecruitingNCT01494142

Search NIH Clinical Center for Eczema Herpeticum


Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

About this section

Anatomical Context for Eczema Herpeticum

About this section

MalaCards organs/tissues related to Eczema Herpeticum:

36
Skin, Lymph node, T cells, Testes, Colon, Bone, Bone marrow

FMA organs/tissues related to Eczema Herpeticum:

17
Skin

Publications for Eczema Herpeticum

About this section

Articles related to Eczema Herpeticum:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
A child presenting with primary gingivostomatitis and eczema herpeticum. (26864720)
2016
2
Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: AA pilot study. (27523434)
2016
3
Relationship Between the Presence of Eczema Herpeticum and the Significance of Clinical and Laboratory Tests in Korean Children With Atopic Dermatitis. (27713812)
2016
4
Defective natural killer cell activity in a mouse model of eczema herpeticum. (27476888)
2016
5
Management of eczema herpeticum in a Burn Unit. (27812048)
2016
6
A Fatal Case of Eczema Herpeticum With Septic Shock Due to Methicillin-Resistant Staphylococcus aureus. (27369040)
2016
7
Oral treatment with valacyclovir for HSV-2-associated eczema herpeticum in a 9-month-old infant: A case report. (27442669)
2016
8
Validation of database search strategies for the epidemiological study of eczema herpeticum. (26822010)
2016
9
Eczema Herpeticum: Would You Know It If You Saw It? (26241712)
2015
10
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. (26198597)
2015
11
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. (26343451)
2015
12
A corneal dendritic lesion with a skin eruption: eczema herpeticum, an important differential diagnosis. (25636633)
2015
13
Fifteen-minute consultation: eczema herpeticum in a child. (25406412)
2014
14
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. (24379126)
2014
15
Eczema Herpeticum in a Wrestler. (24714395)
2014
16
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. (25159465)
2014
17
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? (23387866)
2013
18
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. (22994962)
2013
19
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. (23600999)
2013
20
Topical corticosteroids and hospital length of stay in children with eczema herpeticum. (23039248)
2013
21
Why is eczema herpeticum unexpectedly rare? (23439082)
2013
22
Eczema herpeticum complicating topical 5-Fluorouracil therapy. (23010835)
2012
23
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). (22908727)
2012
24
Eczema herpeticum: a medical emergency. (23242894)
2012
25
Eczema herpeticum. (22433376)
2012
26
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. (22575249)
2012
27
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. (22113474)
2012
28
Eczema herpeticum. (21852062)
2012
29
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-I^ response. (21458658)
2011
30
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. (21211653)
2011
31
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. (21510509)
2011
32
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. (21255038)
2011
33
Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum. (22110485)
2011
34
Eczema herpeticum in pregnancy. (25386284)
2011
35
The clinical spectrum and therapeutic challenge of eczema herpeticum. (21261703)
2011
36
Eczema herpeticum: making the diagnosis in the emergency department. (18584994)
2011
37
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. (22084327)
2011
38
History of eczema herpeticum is associated with the inability to induce human I^-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis. (20545685)
2010
39
Eczema herpeticum in a patient with terminal renal failure under narrow-band uvb therapy. (20606898)
2010
40
Kaposi's varicelliform eruption (eczema herpeticum) in an infant. (20706828)
2010
41
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)
2010
42
Localized eczema herpeticum with unilateral ocular involvement. (20976420)
2010
43
Eczema herpeticum and eczema vaccinatum in children. (20954612)
2010
44
A case of eczema herpeticum with hailey-hailey disease. (20523813)
2009
45
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. (19541356)
2009
46
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. (19733298)
2009
47
Eczema herpeticum and clinical criteria for investigating smallpox. (19624930)
2009
48
Monomorphic rash on the neck. Eczema herpeticum . (19817343)
2009
49
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
50
Eczema herpeticum in pregnancy and neonatal herpes infection. (18669762)
2008

Variations for Eczema Herpeticum

About this section

Expression for genes affiliated with Eczema Herpeticum

About this section
Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

About this section

Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IRF2
29.5IFNG, TSLP
3
Show member pathways
9.5IFNG, IFNGR1
4
Show member pathways
9.5IFNG, IFNGR1
59.5IFNG, IFNGR1
69.3IDO1, IFNG
7
Show member pathways
9.1IRF3, IRF7
89.1IFNG, IFNGR1, IRF2
9
Show member pathways
9.1IFNG, IFNGR1, TSLP
10
Show member pathways
9.0IFNG, IFNGR1, IRF3
118.8IRF2, IRF3, IRF7
12
Show member pathways
8.2IFNG, IRF2, IRF3, IRF7
13
Show member pathways
8.2IFNG, IRF2, IRF3, IRF7
14
Show member pathways
8.2IFNG, IFNGR1, IRF3, IRF7
15
Show member pathways
8.2IFNG, IFNGR1, IRF3, IRF7
16
Show member pathways
7.8IFNG, IFNGR1, IRF2, IRF3, IRF7
17
Show member pathways
7.8IFNG, IFNGR1, IRF2, IRF3, IRF7
187.6IDO1, IFNG, IRF2, IRF3, IRF7

GO Terms for genes affiliated with Eczema Herpeticum

About this section

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of interferon-gamma-mediated signaling pathwayGO:006033410.1IFNG, IFNGR1
2positive regulation of interleukin-12 productionGO:003273510.0IDO1, IFNG
3MDA-5 signaling pathwayGO:00395309.8IRF3, IRF7
4positive regulation of interferon-alpha productionGO:00327279.8IRF3, IRF7
5positive regulation of interferon-beta productionGO:00327289.8IRF3, IRF7
6positive regulation of type I interferon productionGO:00324819.7IRF3, IRF7
7positive regulation of type I interferon-mediated signaling pathwayGO:00603409.7IRF3, IRF7
8regulation of type I interferon productionGO:00324799.7IRF3, IRF7
9TRIF-dependent toll-like receptor signaling pathwayGO:00356669.6IRF3, IRF7
10type I interferon biosynthetic processGO:00453519.6IRF3, IRF7
11response to virusGO:00096159.2IFNG, IFNGR1, IRF7
12negative regulation of transcription from RNA polymerase II promoterGO:00001228.9IFNG, IRF2, IRF3, IRF7
13defense response to virusGO:00516078.9IFNG, IFNGR1, IRF3, IRF7
14type I interferon signaling pathwayGO:00603378.8IRF2, IRF3, IRF7
15interferon-gamma-mediated signaling pathwayGO:00603338.5IFNG, IFNGR1, IRF2, IRF3, IRF7

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulatory region DNA bindingGO:00009758.8IRF2, IRF3, IRF7

Sources for Eczema Herpeticum

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet