MCID: ECZ002
MIFTS: 52

Eczema Herpeticum malady

Infectious diseases, Eye diseases, Skin diseases categories

Summaries for Eczema Herpeticum

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in human herpesvirus 1 or human herpesvirus 2. the infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including swelling of the lymph nodes, fever and watery blisters. An important gene associated with Eczema Herpeticum is KLK12 (kallikrein-related peptidase 12), and among its related pathways are Immune response IFN alpha beta signaling pathway and MSP-RON Signaling. The compounds polymyxin b and citrulline have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:66 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Aliases & Classifications for Eczema Herpeticum

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Eye diseases, Skin diseases


Aliases & Descriptions:

eczema herpeticum 9 11 46 63
herpes simplex eyelid dermatitis 9 63
herpes simplex dermatitis 9 63
herpes simplex virus eyelid dermatitis 9
herpes simplex dermatitis of eyelid 9
herpes simplex virus dermatitis 9


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Disease Ontology9 DOID:9123
ICD9CM28 054.41
ICD1026 B00.0

Related Diseases for Eczema Herpeticum

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Symptoms for Eczema Herpeticum

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9Disease Ontology
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Symptoms:

9
  • swelling of the lymph nodes
  • fever
  • watery blisters

Drugs & Therapeutics for Eczema Herpeticum

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Eczema Herpeticum

Search NIH Clinical Center for Eczema Herpeticum

Search CenterWatch for Eczema Herpeticum

Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Eczema Herpeticum:

34
Skin, Lymph node, T cells, Breast, Colon, Bone, Bone marrow

FMA organs/tissues related to Eczema Herpeticum:

15
Skin

Animal Models for Eczema Herpeticum or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Eczema Herpeticum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5FLG, IRF2, TSLP, IFNG, IL7R, CAMP
2MP:00053977.2CAMP, IGHE, FLG, IRF2, TSLP, IFNG

Publications for Eczema Herpeticum

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53PubMed
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Articles related to Eczema Herpeticum:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. (24379126)
2014
2
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. (23600999)
2013
3
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? (23387866)
2013
4
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). (22908727)
2012
5
Eczema herpeticum complicating topical 5-Fluorouracil therapy. (23010835)
2012
6
Eczema herpeticum. (22433376)
2012
7
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. (22575249)
2012
8
Eczema herpeticum: a medical emergency. (23242894)
2012
9
The clinical spectrum and therapeutic challenge of eczema herpeticum. (21261703)
2011
10
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. (22084327)
2011
11
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. (21255038)
2011
12
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. (21510509)
2011
13
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. (21211653)
2011
14
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)
2010
15
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. (19541356)
2009
16
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
17
Molecular pathogenesis and clinical implications of eczema herpeticum. (18620613)
2008
18
Risk factors of atopic dermatitis patients for eczema herpeticum. (17170734)
2007
19
Eczema herpeticum complicating Parthenium dermatitis. (16036117)
2005
20
High frequency of detection of herpes simplex virus DNA in the oral cavity of patients with eczema herpeticum. (15316162)
2004
21
Eczema herpeticum localized to area of tinea cruris. (14739507)
2004
22
Eczema herpeticum: a dermatologic emergency. (12430518)
2002
23
Photo quiz. Eczema herpeticum. (11398758)
2001
24
Eczema herpeticum during treatment of atopic dermatitis with 0.1% tacrolimus ointment. (11096198)
2000
25
Detection of Herpes simplex virus DNA in non-herpetic areas of patients with eczema herpeticum. (10773695)
2000
26
Microbiology of infected eczema herpeticum. (9555806)
1998
27
Eczema herpeticum in association with familial benign chronic pemphigus. (8432925)
1993
28
Eczema herpeticum induced by sun exposure. (1634302)
1992
29
Eczema herpeticum occurring in autografted skin. (2061459)
1991
30
Severe eczema herpeticum is associated with prolonged depression of cell-mediated immunity to herpes simplex virus. (2545414)
1989
31
Death from eczema herpeticum in a child with severe eczema, mental retardation and cataracts. (2704016)
1989
32
Eczema herpeticum. Clinical and laboratory features. (2835199)
1988
33
Increasing incidence of eczema herpeticum: analysis of seventy-five cases. (3204177)
1988
34
Treatment of eczema herpeticum with oral acyclovir. (3044093)
1988
35
Eczema herpeticum in three siblings: clinical features and acyclovir treatment. (3546436)
1986
36
Eczema herpeticum treated with oral acyclovir. (3771849)
1986
37
Acyclovir therapy for eczema herpeticum in infants. (4051523)
1985
38
Is eczema herpeticum associated with the use of hot tubs? (4011510)
1985
39
Eczema herpeticum of the child. An unusual manifestation of herpes simplex virus infection. (2996817)
1985
40
Treatment of eczema herpeticum with systemic acyclovir. (3977349)
1985
41
Treatment of eczema herpeticum with vidarabine. (7103530)
1982
42
A case of femoral neuropathy associated with eczema herpeticum. (55494)
1976
43
Editorial: Methylene blue for eczema herpeticum. (1173927)
1975
44
Eczema herpeticum. Treatment with methylene blue and light. (170870)
1975
45
Eczema vaccinatum and eczema herpeticum in Darier disease. (4121405)
1973
46
Visceral involvement by herpes simplex virus in eczema herpeticum. (4300208)
1968
47
ECZEMA HERPETICUM AS COMPLICATION OF DARIER'S DISEASE. (14295511)
1965
48
RECURRENT ECZEMA HERPETICUM. WIDESPREAD CUTANEOUS HERPES SIMPLEX IN ATOPIC PATIENT WITHOUT ACTIVE ATOPIC DERMATITIS. (14164964)
1964
49
Kaposi's varicelliform eruption (eczema herpeticum) treated with prednisone. (13567719)
1958
50
Treatment of eczema herpeticum with gamma globulin. (13468788)
1957

Variations for Eczema Herpeticum

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Expression for genes affiliated with Eczema Herpeticum

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

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51PathCards, 61Thomson Reuters, 56Reactome, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Eczema Herpeticum

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Sources:
46Novoseek, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 12DrugBank
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Compounds related to Eczema Herpeticum according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1polymyxin b469.9IFNG, CAMP
2citrulline46 2510.9IFNG, FLG
3rolipram46 62 3011.8IFNG, CAMP
4salbutamol46 52 30 25 1213.8IGHE, CAMP
5pgd2469.7IGHE, CAMP
6budesonide46 52 1211.6IGHE, IFNG
7calcitriol46 62 25 1212.6CAMP, IFNG, FLG
8fluticasone propionate46 52 62 1212.6IGHE, IFNG
9ionomycin469.5CAMP, IL7R, IFNG
10pentoxifylline46 1210.5CAMP, IFNG
112,5-oligoadenylate469.5OAS2, IRF2, IFNG
12l-nmma469.4IFNG, IGHE
13tarc469.4IGHE, TSLP, IFNG
14ivig469.3IGHE, IFNG
15infliximab46 52 1211.3IGHE, FLG, IFNG
16pge1469.2CAMP, IGHE
17histamine46 30 2511.2CAMP, IFNG, IGHE
18actinomycin d469.1CAMP, IFNG, IGHE
19heparin46 30 25 1212.1CAMP, IL7R, IGHE
20nitric oxide46 25 1211.1CAMP, IFNG, IRF2, FLG
21allergens469.0IFNG, TSLP, FLG, IGHE
22tyrosine468.9CAMP, IL7R, TSLP, IRF2, FLG
23retinoic acid46 259.5IGHE, FLG, IRF2, IFNG, CAMP

GO Terms for genes affiliated with Eczema Herpeticum

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17Gene Ontology
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Biological processes related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type I interferon signaling pathwayGO:0603379.7IRF2, OAS2
2establishment of skin barrierGO:0614369.5FLG, FLG2
3interferon-gamma-mediated signaling pathwayGO:0603339.2IFNG, IRF2, OAS2
4cytokine-mediated signaling pathwayGO:0192218.9OAS2, IRF2, IFNG

Molecular functions related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.4IL7R, IGHE

Products for genes affiliated with Eczema Herpeticum

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eczema Herpeticum

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet