MCID: ECZ002
MIFTS: 49

Eczema Herpeticum malady

Categories: Infectious diseases, Skin diseases, Eye diseases

Aliases & Classifications for Eczema Herpeticum

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Aliases & Descriptions for Eczema Herpeticum:

Name: Eczema Herpeticum 10 47 12 65
Herpes Simplex Eyelid Dermatitis 10 65
Herpes Simplex Dermatitis 10 65
 
Herpes Simplex Virus Eyelid Dermatitis 10
Herpes Simplex Dermatitis of Eyelid 10
Herpes Simplex Virus Dermatitis 10

Classifications:



External Ids:

Disease Ontology10 DOID:9123
ICD1027 B00.0
ICD9CM29 054.0, 054.41
MeSH36 D007617
NCIt42 C35620
UMLS65 C0153037, C0854331, C0936250

Summaries for Eczema Herpeticum

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Disease Ontology:10 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including watery blisters, fever and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways are Type II interferon signaling (IFNG) and TSLP Signaling Pathway. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:68 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

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Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Symptoms for Eczema Herpeticum

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Symptoms:

 10
  • watery blisters
  • fever
  • swelling of the lymph nodes

Drugs & Therapeutics for Eczema Herpeticum

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Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FormaldehydeexperimentalPhase 07350-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
2Immunologic Factors18483
3methicillin148
4Anti-Infective Agents17220
5VaccinesPhase 06085
6interferons1930
7Antiviral Agents8071
8Interferon-gamma137

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic DermatitisCompletedNCT00438022
2The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA)CompletedNCT00822276
3Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic DermatitisCompletedNCT00515047
4ADRN Influenza Vaccine PilotCompletedNCT01518478Phase 0
5ADRN Barrier/Immunoprofiling Exploratory Pilot StudyCompletedNCT02115399
6Role of Antimicrobial Peptides in Host Defense Against Vaccinia VirusCompletedNCT00407069
7Atopic Dermatitis Research Network (ADRN) Influenza Vaccine StudyCompletedNCT01737710
8Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and PsoriasisCompletedNCT00407979
9Immune Response to Varicella Vaccination in Children With Atopic DermatitisCompletedNCT00406081
10Interferon Responses in Eczema HerpeticumRecruitingNCT01429311
11Registry for the Atopic Dermatitis Research NetworkRecruitingNCT01494142

Search NIH Clinical Center for Eczema Herpeticum

Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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MalaCards organs/tissues related to Eczema Herpeticum:

33
Skin, Lymph node, Thyroid, Prostate, Bone, Colon, Breast

FMA organs/tissues related to Eczema Herpeticum:

16
Skin

Animal Models for Eczema Herpeticum or affiliated genes

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MGI Mouse Phenotypes related to Eczema Herpeticum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.4CAMP, IFNG, IL7R, IRF2, IRF7, TSLP
2MP:00053876.4CAMP, IFNG, IL7R, IRF2, IRF3, IRF7

Publications for Eczema Herpeticum

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Articles related to Eczema Herpeticum:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Validation of database search strategies for the epidemiological study of eczema herpeticum. (26822010)
2016
2
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. (26198597)
2015
3
A corneal dendritic lesion with a skin eruption: eczema herpeticum, an important differential diagnosis. (25636633)
2015
4
Eczema Herpeticum in a Wrestler. (24714395)
2014
5
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. (24379126)
2014
6
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. (23600999)
2013
7
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). (22908727)
2012
8
Eczema herpeticum complicating topical 5-Fluorouracil therapy. (23010835)
2012
9
Eczema herpeticum. (22433376)
2012
10
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. (22575249)
2012
11
Eczema herpeticum: a medical emergency. (23242894)
2012
12
The clinical spectrum and therapeutic challenge of eczema herpeticum. (21261703)
2011
13
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. (22084327)
2011
14
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. (21255038)
2011
15
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. (21510509)
2011
16
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)
2010
17
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. (19541356)
2009
18
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
19
Molecular pathogenesis and clinical implications of eczema herpeticum. (18620613)
2008
20
Eczema herpeticum complicating Parthenium dermatitis. (16036117)
2005
21
High frequency of detection of herpes simplex virus DNA in the oral cavity of patients with eczema herpeticum. (15316162)
2004
22
Eczema herpeticum: a dermatologic emergency. (12430518)
2002
23
Photo quiz. Eczema herpeticum. (11398758)
2001
24
Eczema herpeticum during treatment of atopic dermatitis with 0.1% tacrolimus ointment. (11096198)
2000
25
Detection of Herpes simplex virus DNA in non-herpetic areas of patients with eczema herpeticum. (10773695)
2000
26
Microbiology of infected eczema herpeticum. (9555806)
1998
27
Eczema herpeticum in association with familial benign chronic pemphigus. (8432925)
1993
28
Eczema herpeticum induced by sun exposure. (1634302)
1992
29
Eczema herpeticum occurring in autografted skin. (2061459)
1991
30
A rapidly progressive papulovesicular eruption. Eczema herpeticum/Kaposi's varicelliform eruption. (2684026)
1989
31
Severe eczema herpeticum is associated with prolonged depression of cell-mediated immunity to herpes simplex virus. (2545414)
1989
32
Death from eczema herpeticum in a child with severe eczema, mental retardation and cataracts. (2704016)
1989
33
Eczema herpeticum. Clinical and laboratory features. (2835199)
1988
34
Increasing incidence of eczema herpeticum: analysis of seventy-five cases. (3204177)
1988
35
Treatment of eczema herpeticum with oral acyclovir. (3044093)
1988
36
Eczema herpeticum in three siblings: clinical features and acyclovir treatment. (3546436)
1986
37
Eczema herpeticum treated with oral acyclovir. (3771849)
1986
38
Acyclovir therapy for eczema herpeticum in infants. (4051523)
1985
39
Is eczema herpeticum associated with the use of hot tubs? (4011510)
1985
40
Eczema herpeticum of the child. An unusual manifestation of herpes simplex virus infection. (2996817)
1985
41
Treatment of eczema herpeticum with systemic acyclovir. (3977349)
1985
42
A case of femoral neuropathy associated with eczema herpeticum. (55494)
1976
43
Editorial: Methylene blue for eczema herpeticum. (1173927)
1975
44
Eczema vaccinatum and eczema herpeticum in Darier disease. (4121405)
1973
45
Visceral involvement by herpes simplex virus in eczema herpeticum. (4300208)
1968
46
ECZEMA HERPETICUM AS COMPLICATION OF DARIER'S DISEASE. (14295511)
1965
47
RECURRENT ECZEMA HERPETICUM. WIDESPREAD CUTANEOUS HERPES SIMPLEX IN ATOPIC PATIENT WITHOUT ACTIVE ATOPIC DERMATITIS. (14164964)
1964
48
Kaposi's varicelliform eruption (eczema herpeticum) treated with prednisone. (13567719)
1958
49
Treatment of eczema herpeticum with gamma globulin. (13468788)
1957
50

Variations for Eczema Herpeticum

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Expression for genes affiliated with Eczema Herpeticum

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Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

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Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IRF2
29.6IL7R, TSLP
3
Show member pathways
9.3IRF3, IRF7
4
Show member pathways
9.2IFNG, IL7R, TSLP
59.2IFNG, IL7R, TSLP
69.1IFNG, IL7R, IRF2
7
Show member pathways
8.9IRF2, IRF3, IRF7
8
Show member pathways
8.9IRF2, IRF3, IRF7
98.9IRF2, IRF3, IRF7
10
Show member pathways
8.5IFNG, IRF2, IRF3, IRF7
11
Show member pathways
8.5IFNG, IRF2, IRF3, IRF7
12
Show member pathways
7.1CAMP, IFNG, IL7R, IRF2, IRF3, IRF7

GO Terms for genes affiliated with Eczema Herpeticum

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Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MDA-5 signaling pathwayGO:003953010.0IRF3, IRF7
2response to virusGO:000961510.0IFNG, IRF7
3positive regulation of interferon-beta productionGO:003272810.0IRF3, IRF7
4type I interferon signaling pathwayGO:006033710.0IRF3, IRF7
5regulation of immune responseGO:005077610.0IFNG, IRF7
6positive regulation of interferon-alpha productionGO:00327279.9IRF3, IRF7
7toll-like receptor signaling pathwayGO:00022249.7IRF3, IRF7
8toll-like receptor 3 signaling pathwayGO:00341389.4IRF3, IRF7
9TRIF-dependent toll-like receptor signaling pathwayGO:00356669.3IRF3, IRF7
10cellular response to lipopolysaccharideGO:00712229.2CAMP, IFNG
11defense response to bacteriumGO:00427429.1CAMP, IFNG
12MyD88-independent toll-like receptor signaling pathwayGO:00027569.0IRF3, IRF7
13cytokine-mediated signaling pathwayGO:00192218.8IFNG, IL7R, IRF3, IRF7
14regulation of transcription, DNA-templatedGO:00063558.6IFNG, IRF2, IRF3, IRF7
15negative regulation of transcription from RNA polymerase II promoterGO:00001228.6IFNG, IRF2, IRF3, IRF7

Sources for Eczema Herpeticum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet