MCID: ECZ002
MIFTS: 45

Eczema Herpeticum malady

Categories: Infectious diseases, Skin diseases, Eye diseases

Aliases & Classifications for Eczema Herpeticum

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Aliases & Descriptions for Eczema Herpeticum:

Name: Eczema Herpeticum 10 47 12 65
Herpes Simplex Eyelid Dermatitis 10 65
Herpes Simplex Dermatitis 10 65
 
Herpes Simplex Virus Eyelid Dermatitis 10
Herpes Simplex Dermatitis of Eyelid 10
Herpes Simplex Virus Dermatitis 10

Classifications:



External Ids:

Disease Ontology10 DOID:9123
ICD1027 B00.0
ICD9CM29 054.0, 054.41
MeSH36 D007617
NCIt42 C35620
UMLS65 C0153037, C0854331, C0936250

Summaries for Eczema Herpeticum

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Disease Ontology:10 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to leukemia and breast cancer, and has symptoms including watery blisters, fever and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways are Type II interferon signaling (IFNG) and TSLP Signaling Pathway. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:68 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

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Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Symptoms for Eczema Herpeticum

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Symptoms:

 10
  • watery blisters
  • fever
  • swelling of the lymph nodes

Drugs & Therapeutics for Eczema Herpeticum

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Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FormaldehydeexperimentalPhase 07350-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
2Immunologic Factors18483
3methicillin148
4Anti-Infective Agents17220
5VaccinesPhase 06085
6interferons1930
7Antiviral Agents8071
8Interferon-gamma137

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic DermatitisCompletedNCT00438022
2The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA)CompletedNCT00822276
3Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic DermatitisCompletedNCT00515047
4ADRN Influenza Vaccine PilotCompletedNCT01518478Phase 0
5ADRN Barrier/Immunoprofiling Exploratory Pilot StudyCompletedNCT02115399
6Role of Antimicrobial Peptides in Host Defense Against Vaccinia VirusCompletedNCT00407069
7Atopic Dermatitis Research Network (ADRN) Influenza Vaccine StudyCompletedNCT01737710
8Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and PsoriasisCompletedNCT00407979
9Immune Response to Varicella Vaccination in Children With Atopic DermatitisCompletedNCT00406081
10Interferon Responses in Eczema HerpeticumRecruitingNCT01429311
11Registry for the Atopic Dermatitis Research NetworkRecruitingNCT01494142

Search NIH Clinical Center for Eczema Herpeticum

Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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MalaCards organs/tissues related to Eczema Herpeticum:

33
Skin, Lymph node, Colon, Endothelial, Breast, Prostate, Bone

FMA organs/tissues related to Eczema Herpeticum:

16
Skin

Animal Models for Eczema Herpeticum or affiliated genes

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MGI Mouse Phenotypes related to Eczema Herpeticum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.4CAMP, IFNG, IL7R, IRF2, IRF7, TSLP
2MP:00053876.4CAMP, IFNG, IL7R, IRF2, IRF3, IRF7

Publications for Eczema Herpeticum

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Articles related to Eczema Herpeticum:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Critical reappraisal of primary osseous composite sarcoma (malignant mesenchymoma) - analysis of four cases and literature review. (27102568)
2016
2
Williams-Beuren Syndrome: Experience of 43 Patients and a Report of an Atypical Case from a Tertiary Care Center in India. (26352091)
2015
3
Diagnosing neurogenic thoracic outlet syndrome with the triple stimulation technique. (26092363)
2015
4
Myxoid epithelioid gastrointestinal stromal tumor harboring an unreported PDGFRA mutation: report of a case and review of the literature. (26191304)
2015
5
DNA typing of HLA-A, -C, -B, AND -DRB1 in the children with autism in the Republic of Macedonia. (25666956)
2015
6
Demodex blepharitis mimicking eyelid sebaceous gland carcinoma. (23565576)
2013
7
IRS1, TCF7L2, ADRB1, PPARG, and HHEX polymorphisms associated with atherogenic risk in Mexican population. (24371822)
2013
8
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. (22004789)
2012
9
Unusual presentation of mycosis fungoides as a lump in the scalp. (22173261)
2011
10
Oxidized low-density lipoprotein is negatively correlated with lecithin-cholesterol acyltransferase activity in type 2 diabetes mellitus. (20890173)
2011
11
Periodontal status in oral mucous membrane pemphigoid: initial results of a case-control study. (20659265)
2011
12
Outcomes of iris-claw anterior chamber versus iris-fixated foldable intraocular lens in subluxated lens secondary to Marfan syndrome. (20466427)
2010
13
Neuropoietin activates STAT3 independent of LIFR activation in adipocytes. (20353755)
2010
14
Characterization of Pt-, Pd-spermine complexes for their effect on polyamine pathway and cisplatin resistance in A2780 ovarian carcinoma cells. (20514439)
2010
15
Anti-neutrophil cytoplasmic autoantibodies against bactericidal/permeability-increasing protein in patients with rheumatoid arthritis and their correlation with bronchial involvement. (20107854)
2010
16
Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. (19412175)
2009
17
Efficacy of tocilizumab and evaluation of clinical remission as determined by CDAI and MMP-3 level. (19609487)
2009
18
Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies. (19786834)
2009
19
Beta-glucan recognition by the innate immune system. (19594628)
2009
20
A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function. (19735726)
2009
21
To knockdown survivin gene expression by siRNA in SO-Rb50 cells]. (19176119)
2008
22
Hemostasis activation in thrombophilic subjects with or without a history of venous thrombosis. (17895509)
2008
23
Jumping translocations in hematological malignancies: a cytogenetic study of five cases. (19027489)
2008
24
Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. (17911252)
2007
25
Treatment of Zoon's balanitis with imiquimod 5% cream. (17679189)
2007
26
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. (17077327)
2007
27
Simultaneous evaluation of maspin and CXCR4 in patients with breast cancer. (16751302)
2007
28
Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease. (17222947)
2007
29
Congenital adrenal hyperplasia and P450 oxidoreductase deficiency. (17223983)
2007
30
Endothelial lipase enhances low density lipoprotein binding and cell association in THP-1 macrophages. (17822686)
2007
31
Molecular bases of type II protein S deficiency: the I203-D204 deletion in the EGF4 domain alters GLA domain function. (16409468)
2006
32
Functional magnetic resonance imaging corresponds to Humphrey perimetry in a patient with pituitary adenoma. (16637851)
2006
33
Nonoperative management of pectus carinatum. (16410105)
2006
34
Prognostic significance of histological features and biological parameters in stage I (pT1 and pT2) colorectal adenocarcinoma. (16860493)
2006
35
Cholecystokinin and leptin: their influence upon the eating behaviour and nutrient intake of dialysis patients. (14671048)
2004
36
Incorporation of the genetic control of alcohol dehydrogenase into a physiologically based pharmacokinetic model for ethanol in humans. (14718645)
2004
37
Dealing with death: HMGB1 as a novel target for cancer therapy. (14763124)
2003
38
Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer. (12488298)
2003
39
Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis. (11694330)
2001
40
Personal review: is profound acid inhibition safe? (10632641)
2000
41
Correlation between tumor tissue aromatase, histological pattern and reproductive status in patients with breast cancer]. (9578729)
1998
42
Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations. (9843715)
1998
43
Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma. (9355979)
1997
44
Modulation of the calpain autoproteolysis by calpastatin and phospholipids. (8954105)
1996
45
Changes in CNS neuropeptide FF-like material, pain sensitivity, and opiate dependence following chronic morphine treatment. (8545244)
1995
46
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. (8380905)
1993
47
Individual differences in activity of glutathione peroxidase and catalase studied in monozygotic twins discordant for smoking. (1358148)
1992
48
The child with peptic esophagitis: a correlation of radiologic signs with esophageal pathology. (7146395)
1982
49
Congenital ichthyosiform erythroderma (epidermolytic hyperkeratosis). (4247929)
1970
50

Variations for Eczema Herpeticum

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Expression for genes affiliated with Eczema Herpeticum

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Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

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Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IRF2
29.6IL7R, TSLP
3
Show member pathways
9.3IRF3, IRF7
4
Show member pathways
9.2IFNG, IL7R, TSLP
59.2IFNG, IL7R, TSLP
69.1IFNG, IL7R, IRF2
7
Show member pathways
8.9IRF2, IRF3, IRF7
8
Show member pathways
8.9IRF2, IRF3, IRF7
98.9IRF2, IRF3, IRF7
10
Show member pathways
8.5IFNG, IRF2, IRF3, IRF7
11
Show member pathways
8.5IFNG, IRF2, IRF3, IRF7
12
Show member pathways
7.1CAMP, IFNG, IL7R, IRF2, IRF3, IRF7

GO Terms for genes affiliated with Eczema Herpeticum

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Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MDA-5 signaling pathwayGO:003953010.0IRF3, IRF7
2response to virusGO:000961510.0IFNG, IRF7
3positive regulation of interferon-beta productionGO:003272810.0IRF3, IRF7
4type I interferon signaling pathwayGO:006033710.0IRF3, IRF7
5regulation of immune responseGO:005077610.0IFNG, IRF7
6positive regulation of interferon-alpha productionGO:00327279.9IRF3, IRF7
7toll-like receptor signaling pathwayGO:00022249.7IRF3, IRF7
8toll-like receptor 3 signaling pathwayGO:00341389.4IRF3, IRF7
9TRIF-dependent toll-like receptor signaling pathwayGO:00356669.3IRF3, IRF7
10cellular response to lipopolysaccharideGO:00712229.2CAMP, IFNG
11defense response to bacteriumGO:00427429.1CAMP, IFNG
12MyD88-independent toll-like receptor signaling pathwayGO:00027569.0IRF3, IRF7
13cytokine-mediated signaling pathwayGO:00192218.8IFNG, IL7R, IRF3, IRF7
14regulation of transcription, DNA-templatedGO:00063558.6IFNG, IRF2, IRF3, IRF7
15negative regulation of transcription from RNA polymerase II promoterGO:00001228.6IFNG, IRF2, IRF3, IRF7

Sources for Eczema Herpeticum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet