MCID: ECZ002
MIFTS: 49

Eczema Herpeticum

Categories: Infectious diseases, Skin diseases, Eye diseases

Aliases & Classifications for Eczema Herpeticum

MalaCards integrated aliases for Eczema Herpeticum:

Name: Eczema Herpeticum 12 51 14 69
Herpes Simplex Eyelid Dermatitis 12 69
Kaposi Varicelliform Eruption 41 69
Herpes Simplex Dermatitis 12 69
Herpes Simplex Virus Eyelid Dermatitis 12
Herpes Simplex Dermatitis of Eyelid 12
Herpes Simplex Virus Dermatitis 12
Eczema Herpeticum [ambiguous] 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9123
ICD10 32 B00.0
ICD9CM 34 054.0 054.41
MeSH 41 D007617
NCIt 46 C35620

Summaries for Eczema Herpeticum

Disease Ontology : 12 A herpes simplex that results_in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary : Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and dermatitis, atopic, and has symptoms including watery blisters, fever and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Influenza A. The drugs Formaldehyde and methicillin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 dermatitis 30.4 FLG IFNG TSLP
2 dermatitis, atopic 29.8 CAMP FLG IFNG TSLP
3 herpes simplex 10.5
4 esophagitis, eosinophilic, 1 10.2 FLG TSLP
5 pemphigus 10.2
6 benign chronic pemphigus 10.1
7 pemphigus vulgaris, familial 10.1
8 pemphigus vulgaris 10.1
9 pediatric lymphoma 10.0 IRF3 IRF7
10 hepatitis 10.0
11 peanut allergy 10.0 FLG IFNG
12 interferon gamma, receptor 1, deficiency 10.0 IFNG IFNGR1
13 ichthyosis vulgaris 9.9
14 mycosis fungoides 9.9
15 episodic pain syndrome, familial, 1 9.9
16 burns 9.9
17 cataract 9.9
18 tinea cruris 9.9
19 ichthyosis 9.9
20 perinephritis 9.9
21 femoral neuropathy 9.9
22 folliculitis 9.9
23 neuropathy 9.9
24 genital herpes 9.9
25 smallpox 9.9
26 meningitis 9.9
27 fasciitis 9.9
28 neonatal herpes 9.9
29 pneumococcal meningitis 9.9
30 mumps 9.9 IFNG IRF2
31 lepromatous leprosy 9.9 IFNG IFNGR1
32 food allergy 9.9 FLG IFNG
33 typhoid fever 9.9 IFNG IFNGR1
34 ascaris lumbricoides infection 9.9 IFNG TSLP
35 allergic contact dermatitis 9.9 FLG IFNG
36 salmonellosis 9.9 IFNG IFNGR1
37 contact dermatitis 9.8 FLG IFNG
38 keratoconjunctivitis 9.8 IFNG TSLP
39 lymphadenitis 9.8 IFNG IFNGR1
40 osteomyelitis 9.8 IFNG IFNGR1
41 helicobacter pylori infection 9.8 IFNG IFNGR1
42 schistosomiasis 9.8 IFNG IFNGR1
43 severe acute respiratory syndrome 9.7 IFNG IRF3
44 ige responsiveness, atopic 9.7 FLG IFNG TSLP
45 respiratory system disease 9.6 IFNG TSLP
46 mouth disease 9.5 IFNG IRF3
47 lichen planus 9.5 FLG IFNG
48 viral infectious disease 9.4 IFNG IRF3 IRF7
49 hepatitis c virus 9.4 IFNG IRF3 IRF7
50 hepatitis c 9.4 IFNG IRF3 IRF7

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to Eczema Herpeticum

Symptoms & Phenotypes for Eczema Herpeticum

Symptoms:

12
  • watery blisters
  • fever
  • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CAMP IFNG IFNGR1 IRF2 IRF7 TSLP
2 immune system MP:0005387 9.17 CAMP IFNG IFNGR1 IRF2 IRF3 IRF7

Drugs & Therapeutics for Eczema Herpeticum

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Early Phase 1 50-00-0 712
2 methicillin
3 interferons
4 Vaccines Early Phase 1
5 Anti-Bacterial Agents
6 Anti-Infective Agents
7 Interferon-gamma
8 Antiviral Agents

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic Dermatitis Completed NCT00438022
2 Interferon Responses in Eczema Herpeticum Completed NCT01429311
3 Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic Dermatitis Completed NCT00515047
4 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276
5 Registry for the Atopic Dermatitis Research Network Completed NCT01494142
6 Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Pilot Completed NCT01518478 Early Phase 1 Fluzone® Intradermal (Sanofi Pasteur Inc.)
7 Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Study Completed NCT01737710
8 Immune Response to Varicella Vaccination in Children With Atopic Dermatitis Completed NCT00406081
9 ADRN Barrier/Immunoprofiling Exploratory Pilot Study Completed NCT02115399
10 Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis Completed NCT00407979
11 Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus Completed NCT00407069
12 Etiology of Eczema Herpeticum (EH) Recruiting NCT03038932

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

Anatomical Context for Eczema Herpeticum

The Foundational Model of Anatomy Ontology organs/tissues related to Eczema Herpeticum:

18
Skin

MalaCards organs/tissues related to Eczema Herpeticum:

38
Skin, Lymph Node, Colon, T Cells, Testes, Bone, Bone Marrow

Publications for Eczema Herpeticum

Articles related to Eczema Herpeticum:

(show top 50) (show all 143)
# Title Authors Year
1
ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. ( 29371118 )
2018
2
Eczema Herpeticum. ( 28992872 )
2017
3
Epidemiology of eczema herpeticum in hospitalized US children: Analysis of a nationwide cohort. ( 28927889 )
2017
4
Eczema Herpeticum. ( 28813215 )
2017
5
Eczema herpeticum in early pregnancy. ( 28385896 )
2017
6
Characterization of children with recurrent eczema herpeticum and response to treatment with interferon-gamma. ( 29144049 )
2017
7
Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. ( 29155096 )
2017
8
A Fatal Case of Eczema Herpeticum With Septic Shock Due to Methicillin-Resistant Staphylococcus aureus. ( 27369040 )
2016
9
Relationship Between the Presence of Eczema Herpeticum and the Significance of Clinical and Laboratory Tests in Korean Children With Atopic Dermatitis. ( 27713812 )
2016
10
Validation of database search strategies for the epidemiological study of eczema herpeticum. ( 26822010 )
2016
11
Management of eczema herpeticum in a Burn Unit. ( 27812048 )
2016
12
Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: AA pilot study. ( 27523434 )
2016
13
Defective natural killer cell activity in a mouse model of eczema herpeticum. ( 27476888 )
2016
14
A child presenting with primary gingivostomatitis and eczema herpeticum. ( 26864720 )
2016
15
Oral treatment with valacyclovir for HSV-2-associated eczema herpeticum in a 9-month-old infant: A case report. ( 27442669 )
2016
16
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. ( 26198597 )
2015
17
Eczema Herpeticum: Would You Know It If You Saw It? ( 26241712 )
2015
18
A corneal dendritic lesion with a skin eruption: eczema herpeticum, an important differential diagnosis. ( 25636633 )
2015
19
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. ( 26343451 )
2015
20
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. ( 25159465 )
2014
21
Fifteen-minute consultation: eczema herpeticum in a child. ( 25406412 )
2014
22
Eczema Herpeticum in a Wrestler. ( 24714395 )
2014
23
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. ( 24379126 )
2014
24
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? ( 23387866 )
2013
25
Why is eczema herpeticum unexpectedly rare? ( 23439082 )
2013
26
Topical corticosteroids and hospital length of stay in children with eczema herpeticum. ( 23039248 )
2013
27
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. ( 22994962 )
2013
28
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. ( 23600999 )
2013
29
Eczema herpeticum. ( 22433376 )
2012
30
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). ( 22908727 )
2012
31
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. ( 22113474 )
2012
32
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. ( 22575249 )
2012
33
Eczema herpeticum. ( 21852062 )
2012
34
Eczema herpeticum: a medical emergency. ( 23242894 )
2012
35
Eczema herpeticum complicating topical 5-Fluorouracil therapy. ( 23010835 )
2012
36
Eczema herpeticum in pregnancy. ( 25386284 )
2011
37
The clinical spectrum and therapeutic challenge of eczema herpeticum. ( 21261703 )
2011
38
Eczema herpeticum: making the diagnosis in the emergency department. ( 18584994 )
2011
39
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. ( 21510509 )
2011
40
Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum. ( 22110485 )
2011
41
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. ( 22084327 )
2011
42
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. ( 21255038 )
2011
43
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-I^ response. ( 21458658 )
2011
44
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. ( 21211653 )
2011
45
Eczema herpeticum and eczema vaccinatum in children. ( 20954612 )
2010
46
Localized eczema herpeticum with unilateral ocular involvement. ( 20976420 )
2010
47
History of eczema herpeticum is associated with the inability to induce human I^-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis. ( 20545685 )
2010
48
Kaposi's varicelliform eruption (eczema herpeticum) in an infant. ( 20706828 )
2010
49
Eczema herpeticum in a patient with terminal renal failure under narrow-band uvb therapy. ( 20606898 )
2010
50
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. ( 20466416 )
2010

Variations for Eczema Herpeticum

Expression for Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for Eczema Herpeticum

Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 IFNG IFNGR1 IRF2 IRF3 IRF7
2
Show member pathways
12.4 IFNG IFNGR1 IRF3 IRF7
3
Show member pathways
12.3 IFNG IRF2 IRF3 IRF7
4
Show member pathways
12.26 IFNGR1 IRF3 IRF7
5 12.14 IFNG IRF2 IRF3 IRF7
6
Show member pathways
12.07 IFNG IFNGR1 TSLP
7
Show member pathways
12.05 IFNG IFNGR1 IRF3 IRF7
8
Show member pathways
11.93 IFNG IFNGR1 IRF3
9 11.92 CAMP IFNG IFNGR1
10 11.8 IRF2 IRF3 IRF7
11
Show member pathways
11.56 IFNG IFNGR1
12
Show member pathways
11.51 IFNG IFNGR1 IRF2 IRF3 IRF7
13
Show member pathways
11.47 IFNG IRF2 IRF3 IRF7
14 11.45 IFNG IRF2
15
Show member pathways
11.26 IFNG IFNGR1
16 11.04 IFNG TSLP
17 10.9 IFNG IFNGR1 IRF2
18
Show member pathways
10.89 IRF3 IRF7

GO Terms for Eczema Herpeticum

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.83 IFNG IRF2 IRF3 IRF7
2 response to virus GO:0009615 9.58 IFNG IFNGR1 IRF7
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 IFNG TSLP
4 positive regulation of type I interferon production GO:0032481 9.54 IRF3 IRF7
5 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.51 IRF3 IRF7
6 type I interferon signaling pathway GO:0060337 9.5 IRF2 IRF3 IRF7
7 positive regulation of interferon-beta production GO:0032728 9.49 IRF3 IRF7
8 regulation of type I interferon production GO:0032479 9.48 IRF3 IRF7
9 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.46 IFNG IFNGR1
10 positive regulation of interferon-alpha production GO:0032727 9.43 IRF3 IRF7
11 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.37 IRF3 IRF7
12 type I interferon biosynthetic process GO:0045351 9.26 IRF3 IRF7
13 defense response to virus GO:0051607 9.26 IFNG IRF2 IRF3 IRF7
14 MDA-5 signaling pathway GO:0039530 9.16 IRF3 IRF7
15 interferon-gamma-mediated signaling pathway GO:0060333 9.02 IFNG IFNGR1 IRF2 IRF3 IRF7

Sources for Eczema Herpeticum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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