MCID: ECZ002
MIFTS: 49

Eczema Herpeticum malady

Infectious diseases, Eye diseases categories

Summaries for Eczema Herpeticum

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in human herpesvirus 1 or human herpesvirus 2. the infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including swelling of the lymph nodes, watery blisters and fever. An important gene associated with Eczema Herpeticum is TSLP (thymic stromal lymphopoietin), and among its related pathways are TSLP Signaling Pathway and MSP-RON Signaling. The compounds ionomycin and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related mouse phenotypes are integument and immune system.

Wikipedia:63 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Aliases & Classifications for Eczema Herpeticum

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Eye diseases


Aliases & Descriptions:

eczema herpeticum 8 10 44 60
herpes simplex eyelid dermatitis 8 60
herpes simplex dermatitis 8 60
herpes simplex virus eyelid dermatitis 8
herpes simplex dermatitis of eyelid 8
herpes simplex virus dermatitis 8


External Ids:

Disease Ontology8 DOID:9123
ICD9CM27 054.41
ICD1025 B00.0

Related Diseases for Eczema Herpeticum

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis31.1IFNG, FLG, DSC1, IGHE, TSLP
2atopic dermatitis31.1CAMP, IFNG, FLG, IGHE, CDSN, TSLP
3pemphigus30.6DSC1
4ichthyosis vulgaris30.2FLG, FLG2
5herpes simplex10.7
6genital herpes10.2
7perinephritis10.2
8folliculitis10.2
9hailey-hailey disease10.2
10infectious mononucleosis10.2
11tinea cruris10.2
12femoral neuropathy10.2
13mycosis fungoides10.2
14cataract10.2
15fasciitis10.2
16meningitis10.2
17neuropathy10.2
18smallpox10.2
19omenn syndrome10.0IGHE
20eosinophilic esophagitis10.0TSLP
21sinusitis10.0IGHE
22rhinitis10.0IGHE
23strongyloidiasis10.0IGHE
24mumps10.0IRF2
25pulmonary eosinophilia10.0IGHE
26lichen planus10.0FLG
27contact dermatitis10.0FLG
28cholesteatoma10.0FLG
29candidiasis10.0IFNG
30keratosis10.0FLG
31hyper ige syndrome10.0IGHE, IFNG
32tetanus10.0IFNG
33congenital ichthyosiform erythroderma10.0FLG
34hepatitis c10.0IL7R, IFNG
35gamma chain deficiency10.0TSLP, IL7R
36nonepidermolytic palmoplantar keratoderma10.0FLG, KLK8
37hepatitis b10.0IFNG
38atopy10.0IFNG, FLG, IGHE, TSLP
39allergic rhinitis10.0IFNG, FLG, IGHE, TSLP
40netherton syndrome10.0DSC1, IGHE, CDSN, TSLP
41severe combined immunodeficiency10.0IL7R, IFNG
42leukemia10.0IL7R, CRLF2, IRF2, IFNG
43allergic asthma10.0IFNG, CRLF2, FLG, IGHE, TSLP
44viral infectious disease10.0TSLP, IL7R, IRF2, IFNG
45asthma10.0CAMP, IFNG, FLG, IGHE, TSLP
46psoriasis9.9KLK8, CASP14, CAMP, IFNG, IRF2, FLG
47skin disease9.9CAMP, IFNG, IRF2, FLG, DSC1, IGHE

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to eczema herpeticum

Clinical Features for Eczema Herpeticum

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8Disease Ontology
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Symptoms:

8
  • swelling of the lymph nodes
  • watery blisters
  • fever

Drugs & Therapeutics for Eczema Herpeticum

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Eczema Herpeticum

Drug clinical trials:

Search ClinicalTrials for Eczema Herpeticum

Search NIH Clinical Center for Eczema Herpeticum

Search CenterWatch for Eczema Herpeticum

Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Eczema Herpeticum:

32
Skin, Lymph node, T cells, Colon, Breast, Bone marrow, Bone

FMA organs/tissues related to Eczema Herpeticum:

14
Skin

Animal Models for Eczema Herpeticum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eczema Herpeticum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0TSLP
2MP:00053877.8IFNG, IRF2, FLG, DSC1, IGHE, CDSN

Publications for Eczema Herpeticum

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50PubMed
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Articles related to Eczema Herpeticum:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. (24379126)
2014
2
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. (22994962)
2013
3
Why is eczema herpeticum unexpectedly rare? (23439082)
2013
4
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). (22908727)
2012
5
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. (22113474)
2012
6
Eczema herpeticum. (21852062)
2012
7
The clinical spectrum and therapeutic challenge of eczema herpeticum. (21261703)
2011
8
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. (21255038)
2011
9
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. (21510509)
2011
10
History of eczema herpeticum is associated with the inability to induce human I^-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis. (20545685)
2010
11
Eczema herpeticum and eczema vaccinatum in children. (20954612)
2010
12
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. (19541356)
2009
13
A case of eczema herpeticum with hailey-hailey disease. (20523813)
2009
14
Images in emergency medicine. Eczema herpeticum. (18565383)
2008
15
Eczema herpeticum: a case report. (15790373)
2005
16
Eczema herpeticum in a patient with atopicdermatitis treated with topical tacrolimus. (16185024)
2005
17
Eczema herpeticum during treatment of atopic dermatitis with 1% pimecrolimus cream. (16396803)
2005
18
High frequency of detection of herpes simplex virus DNA in the oral cavity of patients with eczema herpeticum. (15316162)
2004
19
Photo Quiz. What is your diagnosis? Eczema herpeticum superinfection in a patient with pemphigus vulgaris. (15186043)
2004
20
Eczema herpeticum: a dermatologic emergency. (12430518)
2002
21
Eczema herpeticum in two elderly patients. (17656983)
2002
22
Recurrent eczema herpeticum: an underrecognised condition. (11158702)
2001
23
Eczema herpeticum in parthenium dermatitis. (11205385)
2001
24
Eczema herpeticum during treatment of atopic dermatitis with 0.1% tacrolimus ointment. (11096198)
2000
25
Detection of Herpes simplex virus DNA in non-herpetic areas of patients with eczema herpeticum. (10773695)
2000
26
Eczema herpeticum in children with atopic dermatitis. (10910542)
1999
27
Microbiology of infected eczema herpeticum. (9555806)
1998
28
Treatment of recurrent eczema herpeticum in pregnancy with acyclovir. (18476099)
1996
29
Comparison of the association with eczema herpeticum in the two predominant genotypes of herpes simplex virus type 1. (8877767)
1996
30
Concentration and kinetic studies of intravenous acyclovir in serum and breast milk of a patient with eczema herpeticum. (7751454)
1995
31
Severe eczema herpeticum is associated with prolonged depression of cell-mediated immunity to herpes simplex virus. (2545414)
1989
32
Increasing incidence of eczema herpeticum: analysis of seventy-five cases. (3204177)
1988
33
Treatment of eczema herpeticum with oral acyclovir. (3044093)
1988
34
Management of eczema herpeticum. (3372774)
1988
35
Eczema herpeticum: a potentially fatal disease. (3105692)
1987
36
Eczema herpeticum in three siblings: clinical features and acyclovir treatment. (3546436)
1986
37
Is eczema herpeticum associated with the use of hot tubs? (4011510)
1985
38
Treatment of eczema herpeticum with systemic acyclovir. (3977349)
1985
39
Atopic dermatitis, eczema herpeticum, infectious mononucleosis, and depressed cell-mediated immunity. (204057)
1978
40
Eczema herpeticum caused by herpesvirus type 2. A case in a patient with Darier disease. (196558)
1977
41
Eczema herpeticum. (591662)
1977
42
A case of femoral neuropathy associated with eczema herpeticum. (55494)
1976
43
Eczema vaccinatum and eczema herpeticum in Darier disease. (4121405)
1973
44
Recurrent eczema herpeticum associated with ichthyosis vulgaris. (4114690)
1972
45
Eczema herpeticum. (4309780)
1969
46
Eczema herpeticum, primary and recurrent. (4159394)
1966
47
KAPOSI'S SYNDROME: A CASE OF ECZEMA HERPETICUM COMPLICATED BY VARICELLA DURING CONVALESCENCE; REVIEW OF CURRENT OPINIONS. (14261914)
1965
48
RECURRENT ECZEMA HERPETICUM. WIDESPREAD CUTANEOUS HERPES SIMPLEX IN ATOPIC PATIENT WITHOUT ACTIVE ATOPIC DERMATITIS. (14164964)
1964
49
Eczema herpeticum (Kaposi's varicelliform eruption) in an adult. (13642883)
1959
50
Treatment of eczema herpeticum with gamma globulin. (13468788)
1957

Genetic Variations for Eczema Herpeticum

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Expression for genes affiliated with Eczema Herpeticum

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for genes affiliated with Eczema Herpeticum

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG
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Pathways related to Eczema Herpeticum according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TSLP, IL7R, CRLF2
29.5KLK12, KLK8, IFNG
3
Hide members
9.4OAS2, IL7R, IRF2, IFNG
49.3TSLP, IL7R, CRLF2, IFNG

Compounds for genes affiliated with Eczema Herpeticum

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Eczema Herpeticum according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ionomycin449.7IL7R, IFNG, CAMP
22,5-oligoadenylate449.6IFNG, IRF2, OAS2
3allergens449.4TSLP, IGHE, FLG, IFNG
4infliximab44 49 1111.4IGHE, FLG, IFNG
5tarc449.3IFNG, IGHE, TSLP
6retinoic acid44 248.9CASP14, CAMP, IFNG, IRF2, FLG, DSC1

GO Terms for genes affiliated with Eczema Herpeticum

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16Gene Ontology
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Cellular components related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.7CDSN, DSC1
2extracellular regionGO:0055768.2IL7R, CDSN, IGHE, CRLF2, IFNG, CAMP

Biological processes related to Eczema Herpeticum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:0603339.6OAS2, IRF2, IFNG
2negative regulation of myelinationGO:0316429.4IFNG, KLK8
3keratinocyte differentiationGO:0302169.0TGM3, CDSN, FLG

Products for genes affiliated with Eczema Herpeticum

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eczema Herpeticum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet