MCID: ECZ002
MIFTS: 47

Eczema Herpeticum malady

Categories: Infectious diseases, Skin diseases, Eye diseases

Aliases & Classifications for Eczema Herpeticum

Aliases & Descriptions for Eczema Herpeticum:

Name: Eczema Herpeticum 12 52 14 69
Herpes Simplex Eyelid Dermatitis 12 69
Kaposi Varicelliform Eruption 42 69
Herpes Simplex Dermatitis 12 69
Herpes Simplex Virus Eyelid Dermatitis 12
Herpes Simplex Dermatitis of Eyelid 12
Herpes Simplex Virus Dermatitis 12
Eczema Herpeticum [ambiguous] 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9123
ICD10 33 B00.0
ICD9CM 35 054.0 054.41
MeSH 42 D007617
NCIt 47 C35620

Summaries for Eczema Herpeticum

Disease Ontology : 12 A herpes simplex that results_in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary : Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and atopic dermatitis, and has symptoms including watery blisters, fever and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Formaldehyde and methicillin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 dermatitis 10.5
2 atopic dermatitis 10.5
3 herpes simplex 10.3
4 myofibroma 10.1 FLG IFNG
5 oral cavity cancer 10.1 FLG IFNG
6 intravascular papillary endothelial hyperplasia 10.1 IFNG IFNGR1
7 giant cell glioblastoma 10.1 IFNG IFNGR1
8 crustacean allergy 10.1 IFNG IFNGR1
9 heart conduction disease 10.1 IFNG IRF2
10 anal atresia, hypospadias, and penoscrotal inversion 10.1 IFNG IFNGR1
11 microcephaly 10.1 IFNG IFNGR1
12 isolated growth hormone deficiency 10.1 IFNG IFNGR1
13 pemphigus 10.1
14 albinism 10.1 IDO1 IFNG
15 rift valley fever 10.0 IFNG IFNGR1
16 balkan nephropathy 10.0 FLG IFNG
17 tracheitis 10.0 IFNG TSLP
18 chronic thromboembolic pulmonary hypertension 10.0 IDO1 IFNG
19 isolated klippel-feil syndrome 10.0 IDO1 IFNG
20 paratyphoid fever 10.0 FLG IFNG
21 gangliosidosis gm2 10.0 FLG IFNG TSLP
22 hyperimmunoglobulin syndrome 10.0 IFNG IRF3
23 mental retardation, autosomal dominant 18 10.0 FLG IFNG TSLP
24 epidermolysis bullosa 10.0 FLG IFNG TSLP
25 darier disease 10.0
26 pemphigus vulgaris 10.0
27 liver inflammatory pseudotumor 10.0 IFNG IFNGR1
28 severe acute respiratory syndrome 10.0 IRF3 IRF7
29 classic type lipoma 9.9 IFNG IFNGR1
30 spermatocytoma 9.9 IRF3 IRF7
31 benign eccrine breast spiradenoma 9.9 IFNG IFNGR1
32 ichthyosis vulgaris 9.8
33 hailey-hailey disease 9.8
34 mycosis fungoides 9.8
35 burns 9.8
36 cataract 9.8
37 tinea cruris 9.8
38 ichthyosis 9.8
39 perinephritis 9.8
40 femoral neuropathy 9.8
41 folliculitis 9.8
42 neuropathy 9.8
43 genital herpes 9.8
44 smallpox 9.8
45 meningitis 9.8
46 fasciitis 9.8
47 neonatal herpes 9.8
48 pneumococcal meningitis 9.8
49 exophthalmos 9.8 IFNG IRF3 IRF7
50 eczematous dermatitis of eyelid 9.8 IFNG IRF3 IRF7

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to Eczema Herpeticum

Symptoms & Phenotypes for Eczema Herpeticum

Symptoms:

12
  • watery blisters
  • fever
  • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 IDO1 IFNG IFNGR1 IRF2 IRF7 TSLP
2 immune system MP:0005387 9.17 IDO1 IFNG IFNGR1 IRF2 IRF3 IRF7

Drugs & Therapeutics for Eczema Herpeticum

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Early Phase 1 50-00-0 712
2 methicillin
3 interferons
4 Vaccines Early Phase 1
5 Anti-Bacterial Agents
6 Anti-Infective Agents
7 Interferon-gamma
8 Antiviral Agents

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic Dermatitis Completed NCT00515047
2 Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic Dermatitis Completed NCT00438022
3 Interferon Responses in Eczema Herpeticum Completed NCT01429311
4 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276
5 Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Pilot Completed NCT01518478 Early Phase 1
6 Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Study Completed NCT01737710
7 Immune Response to Varicella Vaccination in Children With Atopic Dermatitis Completed NCT00406081
8 ADRN Barrier/Immunoprofiling Exploratory Pilot Study Completed NCT02115399
9 Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis Completed NCT00407979
10 Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus Completed NCT00407069
11 Etiology of Eczema Herpeticum (EH) Recruiting NCT03038932
12 Registry for the Atopic Dermatitis Research Network Recruiting NCT01494142

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

Anatomical Context for Eczema Herpeticum

MalaCards organs/tissues related to Eczema Herpeticum:

39
Skin, Lymph Node, T Cells, Testes, Bone, Colon, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Eczema Herpeticum:

18
Skin

Publications for Eczema Herpeticum

Articles related to Eczema Herpeticum:

(show top 50) (show all 136)
id Title Authors Year
1
A child presenting with primary gingivostomatitis and eczema herpeticum. ( 26864720 )
2016
2
Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: AA pilot study. ( 27523434 )
2016
3
Relationship Between the Presence of Eczema Herpeticum and the Significance of Clinical and Laboratory Tests in Korean Children With Atopic Dermatitis. ( 27713812 )
2016
4
Defective natural killer cell activity in a mouse model of eczema herpeticum. ( 27476888 )
2016
5
Management of eczema herpeticum in a Burn Unit. ( 27812048 )
2016
6
A Fatal Case of Eczema Herpeticum With Septic Shock Due to Methicillin-Resistant Staphylococcus aureus. ( 27369040 )
2016
7
Oral treatment with valacyclovir for HSV-2-associated eczema herpeticum in a 9-month-old infant: A case report. ( 27442669 )
2016
8
Validation of database search strategies for the epidemiological study of eczema herpeticum. ( 26822010 )
2016
9
Eczema Herpeticum: Would You Know It If You Saw It? ( 26241712 )
2015
10
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. ( 26198597 )
2015
11
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. ( 26343451 )
2015
12
A corneal dendritic lesion with a skin eruption: eczema herpeticum, an important differential diagnosis. ( 25636633 )
2015
13
Fifteen-minute consultation: eczema herpeticum in a child. ( 25406412 )
2014
14
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. ( 24379126 )
2014
15
Eczema Herpeticum in a Wrestler. ( 24714395 )
2014
16
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. ( 25159465 )
2014
17
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? ( 23387866 )
2013
18
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. ( 22994962 )
2013
19
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-I^-producing CD8+ T cells. ( 23600999 )
2013
20
Topical corticosteroids and hospital length of stay in children with eczema herpeticum. ( 23039248 )
2013
21
Why is eczema herpeticum unexpectedly rare? ( 23439082 )
2013
22
Eczema herpeticum complicating topical 5-Fluorouracil therapy. ( 23010835 )
2012
23
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). ( 22908727 )
2012
24
Eczema herpeticum: a medical emergency. ( 23242894 )
2012
25
Eczema herpeticum. ( 22433376 )
2012
26
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. ( 22575249 )
2012
27
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. ( 22113474 )
2012
28
Eczema herpeticum. ( 21852062 )
2012
29
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-I^ response. ( 21458658 )
2011
30
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. ( 21211653 )
2011
31
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. ( 21510509 )
2011
32
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. ( 21255038 )
2011
33
Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum. ( 22110485 )
2011
34
Eczema herpeticum in pregnancy. ( 25386284 )
2011
35
The clinical spectrum and therapeutic challenge of eczema herpeticum. ( 21261703 )
2011
36
Eczema herpeticum: making the diagnosis in the emergency department. ( 18584994 )
2011
37
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. ( 22084327 )
2011
38
History of eczema herpeticum is associated with the inability to induce human I^-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis. ( 20545685 )
2010
39
Eczema herpeticum in a patient with terminal renal failure under narrow-band uvb therapy. ( 20606898 )
2010
40
Kaposi's varicelliform eruption (eczema herpeticum) in an infant. ( 20706828 )
2010
41
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. ( 20466416 )
2010
42
Localized eczema herpeticum with unilateral ocular involvement. ( 20976420 )
2010
43
Eczema herpeticum and eczema vaccinatum in children. ( 20954612 )
2010
44
A case of eczema herpeticum with hailey-hailey disease. ( 20523813 )
2009
45
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. ( 19541356 )
2009
46
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. ( 19733298 )
2009
47
Eczema herpeticum and clinical criteria for investigating smallpox. ( 19624930 )
2009
48
Monomorphic rash on the neck. Eczema herpeticum . ( 19817343 )
2009
49
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. ( 18713601 )
2008
50
Eczema herpeticum in pregnancy and neonatal herpes infection. ( 18669762 )
2008

Variations for Eczema Herpeticum

Expression for Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for Eczema Herpeticum

Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 IFNG IFNGR1 IRF2 IRF3 IRF7
2
Show member pathways
12.59 IFNG IFNGR1 IRF3 IRF7
3
Show member pathways
12.36 IFNG IFNGR1 IRF3 IRF7
4
Show member pathways
12.26 IFNG IRF2 IRF3 IRF7
5
Show member pathways
11.9 IFNG IFNGR1 IRF3
6
Show member pathways
11.87 IFNG IFNGR1 TSLP
7 11.85 IDO1 IFNG IRF2 IRF3 IRF7
8 11.78 IRF2 IRF3 IRF7
9
Show member pathways
11.67 IFNG IRF2 IRF3 IRF7
10
Show member pathways
11.56 IFNG IFNGR1
11
Show member pathways
11.51 IFNG IFNGR1 IRF2 IRF3 IRF7
12 11.46 IFNG IRF2
13 11.39 IFNG IFNGR1
14
Show member pathways
11.26 IFNG IFNGR1
15 11.08 IDO1 IFNG
16 11.03 IFNG TSLP
17 11 IFNG IFNGR1 IRF2
18
Show member pathways
10.86 IRF3 IRF7

GO Terms for Eczema Herpeticum

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.84 IFNG IRF2 IRF3 IRF7
2 response to virus GO:0009615 9.58 IFNG IFNGR1 IRF7
3 positive regulation of type I interferon production GO:0032481 9.55 IRF3 IRF7
4 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.52 IRF3 IRF7
5 positive regulation of interferon-beta production GO:0032728 9.51 IRF3 IRF7
6 type I interferon signaling pathway GO:0060337 9.5 IRF2 IRF3 IRF7
7 positive regulation of interleukin-12 production GO:0032735 9.49 IDO1 IFNG
8 regulation of type I interferon production GO:0032479 9.48 IRF3 IRF7
9 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.46 IFNG IFNGR1
10 positive regulation of interferon-alpha production GO:0032727 9.43 IRF3 IRF7
11 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.37 IRF3 IRF7
12 type I interferon biosynthetic process GO:0045351 9.26 IRF3 IRF7
13 defense response to virus GO:0051607 9.26 IFNG IFNGR1 IRF3 IRF7
14 MDA-5 signaling pathway GO:0039530 9.16 IRF3 IRF7
15 interferon-gamma-mediated signaling pathway GO:0060333 9.02 IFNG IFNGR1 IRF2 IRF3 IRF7

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulatory region DNA binding GO:0000975 8.8 IRF2 IRF3 IRF7

Sources for Eczema Herpeticum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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