Summaries for Ehrlichiosis

Sources:
6Disease Ontology, 2CDC, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
CDC: Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.2

MalaCards: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is MAP2 (microtubule-associated protein 2), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Molecular Mechanisms of Cancer. The compounds ivig and pge2 have been mentioned in the context of this disorder. Affiliated tissues include leukocyte and monocytes, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Disease Ontology: A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.6

Wikipedia: Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,...44 more...

Aliases & Descriptions for Ehrlichiosis

Sources:
2CDC, 6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 19ICD9CM, 40SNOMED-CT, 24MeSH
See all sources

Aliases & Descriptions:

ehrlichiosis 6 30 8 32 43
human ehrlichiosis 6 30 43
he 30

External Ids:

ICD9CM19 082.40, 082.4
SNOMED-CT40 77361002

Related Diseases for Ehrlichiosis

Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to ehrlichiosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 580)
idRelated DiseaseScoreTop Affiliating Genes
1human monocytic ehrlichiosis32.6IL18R1, MAP2, GPT, TNFRSF9, CXCL2, RGR
2human granulocytic anaplasmosis32.0SELPLG, FUT7, RGR
3breast cancer29.8ATR, IL10, IFNG, TNF
4hepatitis b28.2IL10, GPT, IFNG
5hepatitis c27.4CD40LG, IL10, GPT, IFNG, TNF
6sepsis27.3IL10, TNF
7type 2 diabetes mellitus26.7IL10, GPT, IFNG, F3, TNF, TFRC
8parkinson's disease26.1CD40LG, IL10, MAP2, IFNG, CASP3, TNF
9immunodeficiency26.0CD40LG, IL10, IL18R1, IFNG, TNF
10thrombosis25.9SELPLG, CD40LG, IL10, GPT, IFNG, F3
11familial hypercholesterolemia25.8CD40LG, IL10, GPT, TNF
12diabetes mellitus25.7CD40LG, IL10, IL18R1, GPT, IFNG, F3
13carcinoma25.7SELPLG, ATR, FUT7, MPP1, FSCN2, CD40LG
14hypercholesterolemia25.6SELPLG, CD40LG, IL10, GPT, F3, TNF
15biliary atresia25.6CD40LG, IL10, GPT, IFNG, CASP3, TNF
16hypertension25.4ATR, CD40LG, IL10, GPT, IFNG, F3
17obesity25.4MMP12, IL10, IL18R1, MAP2, GPT, IFNG
18osteoarthritis25.3MMP12, IL10, IL18R1, GPT, IFNG, CASP3
19purpura25.3CD40LG, IL10, IFNG, F3, TNF
20alzheimer's disease25.3SELPLG, MPP1, CD40LG, IL10, MAP2, IFNG
21thyroiditis25.2MPP1, CD40LG, IL10, GPT, IFNG, F3
22colon carcinoma25.2SELPLG, FUT7, IL10, IFNG, CASP3, TNF
23hepatocellular carcinoma25.2MMP12, IL10, IL18R1, GPT, IFNG, F3
24hepatitis25.1ATR, CD40LG, MMP12, IL10, IL18R1, GPT
25neuroblastoma25.1MPP2, IL18R1, MAP2, IFNG, F3, CASP3
26squamous cell carcinoma25.1MPP1, FSCN2, MMP12, IL10, IL18R1, MAP2
27antiphospholipid syndrome25.1SELPLG, CD40LG, F3, TNF
28adenocarcinoma25.1ATR, FUT7, CD40LG, MMP12, IL10, IL18R1
29neuronitis25.0MPP1, MPP2, CD40LG, IL10, IL18R1, ANK1
30coronary heart disease25.0SELPLG, CD40LG, IL10, IL18R1, GPT, IFNG
31anemia25.0ATR, CD40LG, IL10, ANK1, GPT, IFNG
32nephropathy24.9CD40LG, MMP12, IL10, IFNG, F3, CASP3
33osteosarcoma24.9CD40LG, IL10, IL18R1, IFNG, CASP3, TNF
34myocardial infarction24.7SELPLG, ATR, CD40LG, IL10, GPT, IFNG
35pemphigus foliaceus24.6CD40LG, IL10, TNF
36psoriasis24.6SELPLG, CD40LG, MMP12, IL10, IL18R1, GPT
37schizophrenia24.6MPP2, CD40LG, IL10, IL18R1, MAP2, GPT
38liver cirrhosis24.5IL10, GPT, IFNG, F3, TNF
39t-cell leukemia24.5FUT7, CD40LG, IL10, IL18R1, GPT, IFNG
40leukemia/lymphoma24.5CD40LG, IL10, IL18R1, IFNG, CASP3, TNF
41ovarian carcinoma24.5ATR, MMP12, IL10, IFNG, F3, CASP3
42acute liver failure24.5IL10, GPT, F3, TNF
43retinitis24.4MPP2, FSCN2, CD40LG, IL10, IL18R1, MAP2
44neutropenia24.4CD40LG, IL10, GPT, IFNG, F3, CASP3
45cholangitis24.4CD40LG, IL10, GPT, IFNG, F3, TNF
46tuberculosis24.3IL10, IFNG, TNF
47blindness24.3FSCN2, CD40LG, IL10, GPT, IFNG, F3
48sleep apnea24.3CD40LG, IL10, GPT, TNF
49septic shock24.2IL10, IL18R1, F3, TNF
50pancreatitis24.2ATR, FUT7, MPP2, CD40LG, MMP12, IL10

Graphical network of the top 20 diseases related to ehrlichiosis:



Graphical network of diseases related to ehrlichiosis

Clinical Features for Ehrlichiosis

Sources:
6Disease Ontology
See all sources
Symptoms: headache, muscle aches, fatigue, rash.6

Drugs & Therapeutics for Ehrlichiosis

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for ehrlichiosis

Drug clinical trials:

Search ClinicalTrials for ehrlichiosis

Search NIH Clinical Center for ehrlichiosis

Search CenterWatch for ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

Sources:
11FMA, 22MalaCards
See all sources

MalaCards organs/tissues related to ehrlichiosis:

22
Monocytes

FMA organs/tissues related to ehrlichiosis:

11
Leukocyte

Phenotypes for genes affiliated with Ehrlichiosis

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to ehrlichiosis:

25 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:00053979.6TFRC, TNFRSF9, ANK1, FUT7, ATR
2renal/urinary system phenotypeMP:00053679.3CYBB, CASP3, ANK1, ATR, SELPLG
3integument phenotypeMP:00107718.7TNFRSF9, F3, IFNG, ANK1, ATR, SELPLG
4nervous system phenotypeMP:00036318.7CYBB, F3, MAP2, ANK1, MMP12, FSCN2
5immune system phenotypeMP:00053878.2SELPLG, TFRC, CYBB, TNF, IFNG, ANK1
6digestive/alimentary phenotypeMP:00053818.2TFRC, CYBB, CASP3, IFNG, FUT7, ATR
7homeostasis/metabolism phenotypeMP:00053767.7TFRC, CYBB, CASP3, F3, ANK1, MMP12
8tumorigenesisMP:00020067.3CYBB, TNF, F3, IFNG, IL10, FUT7
9reproductive system phenotypeMP:00053897.0TNF, CASP3, IFNG, ANK1, IL10, MMP12
10vision/eye phenotypeMP:00053916.9TNFRSF9, TNF, CASP3, F3, IFNG, IL10
11cardiovascular system phenotypeMP:00053856.4TFRC, CYBB, TNF, CASP3, F3, IFNG
12cellular phenotypeMP:00053845.8F3, CASP3, TNF, TNFRSF9, TFRC, IFNG
13mortality/agingMP:00107685.6F3, CASP3, TNF, TNFRSF9, CYBB, TFRC

Publications for genes affiliated with Ehrlichiosis

Sources:
35PubMed
See all sources

Articles related to ehrlichiosis:

(show all 17)
idTitleAuthorsYearAffiliating Genes
1Human monocytic ehrlichiosis in children. (17529862)Schutze G.E.... Jacobs R.F.2007GPT
2Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. (14734762)Ismail N.... Walker D.H.2004TNF
3Clinical manifestations, epidemiology, and laboratory diagnosis of human monocytotropic ehrlichiosis in a commercial laboratory setting. (12965923)Olano J.P.... Walker D.H.2003GPT
4Characterization and transcriptional analysis of gene clusters for a type IV secretion machinery in human granulocytic and monocytic ehrlichiosis agents. (11895979)Ohashi N.... Rikihisa Y.2002RIT2
5Serodiagnosis of human granulocytic ehrlichiosis by using novel combinations of immunoreactive recombinant proteins. (11427556)Lodes M.J.... Persing D.H.2001ANK1
6Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. (11337387)Martin M.E.... Dumler J.S.2001IFNG, IL10
7Induction of tissue factor procoagulant activity in m yelomonocytic cells inoculated by the agent of human granulocytic ehrlichiosis. (10669164)Behl R.... Key N.S.2000F3
8Specific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent. (10772341)DiPietrantonio A.M.... Wu J.M.2000CASP3
9Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. (10754283)Banerjee R.... Fikrig E.2000CYBB
10Expression of interleukin-1beta, tumor necrosis facto r alpha, and interleukin-6 in human peripheral blood leukocytes exposed to huma n granulocytic ehrlichiosis agent or recombinant major surface protein P44. (10816490)Kim H.Y.... Rikihisa Y.2000PSMC6
11Molecular cloning and characterization of the 120-kilodalton protein gene of Ehrlichia canis and application of the recombinant 120-kilodalton protein for serodiagnosis of canine ehrlichiosis. (10618118)Yu X.J.... Walker D.H.2000NSUN5
12Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1. (10834846)Herron M.J.... Goodman J.L.2000SELPLG, FUT7
13Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. (10225882)Barnewall R.E.... Rikihisa Y.1999TFRC
14Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand. (9927502)Goodman J.L.... Weston B.W.1999FUT7
15Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. (10024584)Mott J.... Rikihisa Y.1999MPP1, MPP2
16Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. (9455892)Ijdo J.W.... Fikrig E.1998CD40LG
17Immunodiagnosis of human granulocytic ehrlichiosis by using culture-derived human isolates. (9620365)Ravyn M.D.... Johnson R.C.1998CD40LG

Expression for genes affiliated with Ehrlichiosis

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Ehrlichiosis

Pathways for genes affiliated with Ehrlichiosis

Sources:
36QIAGEN, 20KEGG, 37R&D Systems
See all sources

Compounds for genes affiliated with Ehrlichiosis

Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to ehrlichiosis according to GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1ivig32 10.6IL18R1
2pge232 10.6CXCL2
3phosphatidylserine32 9 9 12.5ANK1, SELPLG
4ionomycin32 10.5TNFRSF9, MAP2
5carbohydrates32 10.2TFRC, SELPLG, FUT7
6n acetylcysteine32 10.1MMP12, GPT, CXCL2
7histamine32 18 10.9CD40LG, SELPLG, TFRC
8acridine32 9.7TFRC, MPP2, CASP3
9dmso32 9.7MAP2, F3, CYBB
10rapamycin32 42 10.7IFNG, IL18R1
11vesnarinone32 9.3IFNG, TNF, IL18R1
12oxygen32 18 10.2CYBB, CASP3, MAP2, IL18R1, MMP12, SELPLG
13polysaccharide32 9.1FUT7, SELPLG, CD40LG, TFRC, F3, IL18R1
14blys32 9.0TNF, IL10, CD40LG
15vegf32 8.9IL18R1, CD40LG, CXCL2, CYBB, F3, MAP2
16sb 20358032 42 9.9CXCL2, CASP3, TNF, IFNG
17interferon gamma32 8.9IL10, IFNG, TNF
18tuberculin32 8.8IFNG, CD40LG, IL10
19herbimycin a32 42 9.8TNF, PSMC6, TFRC, IFNG, CD40LG
20mycophenolate mofetil32 9 9 10.7IFNG, CD40LG, IL10, GPT, TFRC
21ribavirin32 34 9 9 11.7CD40LG, IL10, GPT, IFNG
222,5-oligoadenylate32 8.7IL10, TNF, IFNG, GPT
23lactate32 8.7TFRC, CXCL2, CD40LG, GPT, CASP3, TNF
24fibrinogen32 8.6CXCL2, F3, GPT, MMP12, TNF, CD40LG
25tarc32 8.6IFNG, IL10, TNF, CXCL2
26il-1232 8.5CD40LG, IL10, IFNG, TNF
27infliximab32 9 9 10.5IL18R1, IL10, IFNG, TNF
28ccl332 8.4IFNG, CXCL2, TNFRSF9, TNF, IL10
29prednisolone32 9 9 10.4IL10, IL18R1, GPT, TNF, IFNG
30etanercept32 9 9 10.3IL10, IL18R1, MMP12, IFNG, TNF
31cysteine32 8.3SELPLG, MPP2, CD40LG, IL18R1, IFNG, CASP3
32pentoxifylline32 9 9 10.3F3, IFNG, TNF, IL10
33thalidomide32 42 9 9 11.2IL18R1, TNF, IFNG, IL10, CD40LG
34natalizumab32 9 9 10.2IFNG, IL10, TNF
35okt332 8.1IFNG, TNF, TFRC, CD40LG, IL18R1, IL10
36ly29400232 8.0IL10, CASP3, TNF, IL18R1, CXCL2
37tyrosine32 8.0CXCL2, ATR, PSMC6, ANK1, IL18R1, TFRC
38rantes32 7.9IL10, CD40LG, IL18R1, IFNG, TNF, CXCL2
39neopterin32 7.9IL18R1, GPT, TNF, IFNG, TFRC, IL10
4015-deoxy-delta-12,14-prostaglandin j232 7.9IL10, IFNG, TNF, CASP3
41tacrolimus32 34 9 9 10.8TFRC, TNF, GPT, IFNG, IL18R1, IL10
42simvastatin32 34 42 9 18 9 12.8IL10, F3, CASP3, GPT, TNF, IFNG
43genistein32 9 18 9 10.8ATR, CD40LG, CASP3, IFNG, TNF, TFRC
44endotoxin32 7.5CXCL2, CD40LG, IL18R1, IFNG, F3, TNF
45retinoic acid32 42 18 9.5CYBB, TNF, CASP3, F3, TFRC, CD40LG
46nitric oxide32 9 18 9 10.4PSMC6, IL18R1, MMP12, CXCL2, IL10, IFNG
47cyclosporin a32 42 8.4GPT, IFNG, IL10, CD40LG, CASP3, IL18R1
48cycloheximide32 7.1CASP3, TNF, F3, PSMC6, IL10, IFNG
49serine32 7.1CXCL2, TFRC, CYBB, CASP3, F3, MAP2
50dexamethasone32 42 34 9 9 11.0CXCL2, SELPLG, CD40LG, MMP12, IL18R1, IL10

GO Terms for genes affiliated with Ehrlichiosis

Sources:
12Gene Ontology
See all sources

Cellular components related to ehrlichiosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7CD40LG, IFNG, TNF, TNFRSF9
2integral to plasma membraneGO:0058877.9SELPLG, RGR, TFRC, CYBB, TNFRSF9, TNF

Biological processes related to ehrlichiosis according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:0510239.6CD40LG, TNF
2positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4TNF, IFNG
4receptor biosynthetic processGO:0328009.1TNF, IL10
5positive regulation of MHC class II biosynthetic processGO:0453488.9CD40LG, IL10, IFNG
6negative regulation of cytokine secretion involved in immune responseGO:0027408.8IL10, TNF
7negative regulation of growth of symbiont in hostGO:0441308.7IL10, IFNG, TNF
8inflammatory responseGO:0069548.2CXCL2, CYBB, TNF, IL10, CD40LG
9anti-apoptosisGO:0069168.2TNF, F3, IL10, CD40LG, ZC3HC1

Molecular functions related to ehrlichiosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.1CD40LG, IL10, IFNG, TNF

Sources for Ehrlichiosis

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS