HE
MCID: EHR002
MIFTS: 54

Ehrlichiosis (HE) malady

Infectious diseases category

Summaries for Ehrlichiosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including muscle aches, rash and fatigue. An important gene associated with Ehrlichiosis is MAP2 (microtubule-associated protein 2). The compounds succinylacetone and neopterin have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotype immune system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia:63 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Aliases & Classifications for Ehrlichiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
ehrlichiosis:
Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

ehrlichiosis 8 42 10 44 48 60
human ehrlichiosis 8 42 60
he 42


External Ids:

Disease Ontology8 DOID:10242
MeSH34 D016873
ICD9CM27 082.4, 082.40
MESH via Orphanet35 D016873
SNOMED-CT56 77361002
ICD10 via Orphanet26 A48.8
SNOMED-CT via Orphanet57 77361002
UMLS via Orphanet61 C0085399

Related Diseases for Ehrlichiosis

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17GeneCards, 18GeneDecks
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Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1human monocytic ehrlichiosis31.0MAP2, ECHS1, RGR, UCK2, MMP12
2human granulocytic anaplasmosis30.6SELPLG, RGR, FUT7, MMP12
3hepatitis30.0TFRC, GPT
4arthritis29.8IL18R1, MMP12, CXCL2
5malaria29.8MPP1, IL18R1, TFRC
6leukemia29.8CXCL2, IL18R1, TFRC, FUT7, SELPLG, CYBB
7lyme disease10.5
8babesiosis10.5
9rocky mountain spotted fever10.3
10spotted fever10.3
11encephalitis10.3
12tick-borne encephalitis10.2
13toxic shock syndrome10.1
14thrombocytopenia10.1
15tick infestation10.1
16hypereosinophilic syndrome10.1
17primary hypereosinophilic syndrome10.1
18body dysmorphic disorder10.0
19dysentery10.0
20hashimoto's encephalitis10.0
21lymphoid hypereosinophilic syndrome10.0
22secondary hypereosinophilic syndrome10.0
23tuberculosis10.0MPP1
24sickle cell disease10.0TFRC
25anaplastic large cell lymphoma10.0IL18R1
26pneumonia10.0MMP12, CXCL2
27celiac disease10.0MMP12, TFRC
28histiocytosis10.0FSCN2
29sarcoidosis10.0IL18R1, CYBB
30asthma10.0IL18R1, SELPLG, MMP12
31hereditary spherocytosis10.0TFRC, ANK1
32ischemia10.0SELPLG, MAP2, CXCL2
33rhyns syndrome10.0CYBB, FSCN2, RGR
34peritonitis10.0IL18R1, CXCL2, SELPLG
35cadasil10.0SELPLG, IL18R1, MAP2, MMP12
36multiple sclerosis10.0TFRC, IL18R1, MAP2, SELPLG, MMP12
37siderosis10.0TFRC, GPT
38atherosclerosis10.0CYBB, IL18R1, SELPLG, MMP12
39viral infectious disease10.0GPT, TFRC, IL18R1, CXCL2
40ipex syndrome10.0GPT, IL18R1, MAP2, MPP1, TFRC, TNFRSF9
41burkitt's lymphoma10.0MAP2, TFRC, MPP1, FUT7, TNFRSF9
42melanoma10.0MPP1, MAP2, CXCL2, TFRC, IL18R1, MMP12
43hemophagocytic lymphohistiocytosis9.9
44adult respiratory distress syndrome9.9
45tick paralysis9.9
46cat-scratch disease9.9
47sennetsu fever9.9
48q fever9.9
49cerebritis9.9
50chagas disease9.9

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Clinical Features for Ehrlichiosis

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8Disease Ontology
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Symptoms:

8
  • muscle aches
  • rash
  • fatigue
  • headache

Drugs & Therapeutics for Ehrlichiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ehrlichiosis

Drug clinical trials:

Search ClinicalTrials for Ehrlichiosis

Search NIH Clinical Center for Ehrlichiosis

Search CenterWatch for Ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Ehrlichiosis:

32
Monocytes, Testes, T cells, Bone, Bone marrow, Pancreas, B cells, Myeloid, Whole blood, Lung, Eye, Lymph node, Liver

FMA organs/tissues related to Ehrlichiosis:

14
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Ehrlichiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.0FUT7, SELPLG, MMP12, IL18R1, CYBB, ANK1

Publications for Ehrlichiosis

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Sources:
50PubMed
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Articles related to Ehrlichiosis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Myocarditis after trimethoprim/sulfamethoxazole treatment for ehrlichiosis. (24274783)
2013
2
An assessment of whole blood and fractions by nested PCR as a DNA source for diagnosing canine ehrlichiosis and anaplasmosis. (22973174)
2012
3
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. (19955322)
2010
4
Clinical relevance of annual screening using a commercial enzyme-linked immunosorbent assay (SNAP 3Dx) for canine ehrlichiosis. (19411647)
2009
5
Clinical outcomes of solid organ transplant recipients with ehrlichiosis. (19228344)
2009
6
Comparison of two clinic-based immunoassays with the immunofluorescence antibody test for the field diagnosis of canine monocytic ehrlichiosis. (19621766)
2009
7
Diminished hematopoietic activity associated with alterations in innate and adaptive immunity in a mouse model of human monocytic ehrlichiosis. (19451243)
2009
8
All eyes on ehrlichiosis. (19633508)
2009
9
Protective heterologous immunity against fatal ehrlichiosis and lack of protection following homologous challenge. (18285501)
2008
10
Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis. (17562770)
2007
11
Two cases of human granulocytic ehrlichiosis in Sardinia, Italy confirmed by PCR. (17114774)
2006
12
Anti-Hepatozoon canis serum antibodies and gamonts in naturally-occurring canine monocytic ehrlichiosis. (15845277)
2005
13
Clinical, epidemiologic, and environmental surveillance for ehrlichiosis and anaplasmosis in an endemic area of northern California. (16007950)
2005
14
Comparison of patients fulfilling criteria for confirmed and probable human granulocytic ehrlichiosis. (15764167)
2004
15
Human granulocytic ehrlichiosis in Germany: evidence from serological studies, tick analyses, and a case of equine ehrlichiosis. (12860611)
2003
16
A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in Germany. (12740667)
2003
17
Human Granulocytic Ehrlichiosis in Belgium: an underestimated cause of disease. (12860146)
2003
18
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
19
Serologic evidence of ehrlichiosis among humans and wild animals in The Netherlands. (11915850)
2002
20
Treatment of human granulocytic ehrlichiosis during pregnancy and risk of perinatal transmission. (12578161)
2002
21
Diagnosis of human granulocytic ehrlichiosis: state of the art. (12804164)
2002
22
Seroprevalence of human granulocytic ehrlichiosis in high-risk groups in Denmark. (11303811)
2001
23
Susceptibility of cattle to infection with Ehrlichia equi and the agent of human granulocytic ehrlichiosis. (11318369)
2001
24
Coinfecting deer-associated zoonoses: Lyme disease, babesiosis, and ehrlichiosis. (11486290)
2001
25
First cases of acute human granulocytic ehrlichiosis in Poland. (11347671)
2001
26
The first report of canine ehrlichiosis in Australia. (11599816)
2001
27
Ehrlichiosis ... in Hawaii? An unusual presentation. (10832209)
2000
28
Human granulocytic ehrlichiosis in Northern California: two case descriptions with genetic analysis of the Ehrlichiae. (10476747)
1999
29
Infection of laboratory mice with the human granulocytic ehrlichiosis agent does not induce antibodies to diagnostically significant Borrelia burgdorferi antigens. (10325386)
1999
30
Epidemiological aspects of human granulocytic Ehrlichiosis in southern Germany. (10666819)
1999
31
Ehrlichiosis--ticks, dogs, and doxycycline. (10403860)
1999
32
Disparity in the natural cycles of Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis. (10221871)
1999
33
Human granulocytic ehrlichiosis during pregnancy treated successfully with rifampin. (9675481)
1998
34
Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. (9632594)
1998
35
Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. (9817875)
1998
36
Human granulocytic ehrlichiosis in New York. (9554683)
1998
37
Investigation of splenic functions in canine monocytic ehrlichiosis. (9618865)
1998
38
Human ehrlichiosis in central Europe. (10048172)
1998
39
Ehrlichiosis in children. (9290602)
1997
40
Deer ticks (Ixodes scapularis) and the agents of Lyme disease and human granulocytic ehrlichiosis in a New York City park. (9284380)
1997
41
Human ehrlichiosis in Thailand. (9298007)
1997
42
Comparison of major antigenic proteins of six strains of the human granulocytic ehrlichiosis agent by Western immunoblot analysis. (9316916)
1997
43
An indirect immunofluorescence assay using a cell culture-derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis. (9163471)
1997
44
A case of acute monocytic ehrlichiosis with prominent neurologic signs. (9191777)
1997
45
Polymerase chain reaction evidence of Ehrlichia chaffeensis, an etiologic agent of human ehrlichiosis, in dogs from southeast Virginia. (8836370)
1996
46
Ehrlichiosis--in pursuit of an emerging infection. (8532005)
1996
47
Direct cultivation of the causative agent of human granulocytic ehrlichiosis. (8531996)
1996
48
Human ehrlichiosis in a liver transplant recipient. (7482752)
1995
49
Human ehrlichiosis in the UK. (7491006)
1995
50
Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR. (8567911)
1995

Genetic Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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Compounds for genes affiliated with Ehrlichiosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Ehrlichiosis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1succinylacetone4410.4TFRC, CYBB
2neopterin4410.3GPT, TFRC, IL18R1
3polylactosamine4410.2FUT7, SELPLG
4acridine4410.1TFRC, MPP2
5polysaccharide4410.1FUT7, IL18R1, TFRC, SELPLG
6n acetylcysteine4410.1TFRC, CXCL2, MMP12, GPT
7sialic acid4410.0TFRC, SELPLG, FUT7
8ethanol44 49 11 2413.0GPT, CXCL2, MAP2, IL18R1
9fibrinogen4410.0SELPLG, GPT, MMP12, CXCL2
10oxygen44 2410.9CYBB, CXCL2, IL18R1, MMP12, SELPLG
11vegf449.8MMP12, IL18R1, CXCL2, CYBB, MAP2, TFRC
12mannose 6-phosphate44 2410.7MPP2, TFRC, MPP1
13serine449.7CXCL2, CYBB, SELPLG, IL18R1, MMP12, MAP2
14dexamethasone44 49 28 1112.6TNFRSF9, TFRC, CXCL2, IL18R1, MMP12, SELPLG
15glucose449.6MPP1, MAP2, GPT, IL18R1, MPP2, CYBB
16lipid449.6GPT, MMP12, IL18R1, CXCL2, ANK1, MPP1
17glycogen44 2410.4MPP2, MAP2, CXCL2, GPT
18tyrosine448.9SELPLG, NSUN5, MAP2, CYBB, CXCL2, IL18R1

GO Terms for genes affiliated with Ehrlichiosis

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16Gene Ontology
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Cellular components related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stereociliumGO:03242010.1FSCN2, MPP1
2cortical cytoskeletonGO:0308639.8ANK1, MPP1
3integral to plasma membraneGO:0058879.1SELPLG, TNFRSF9, TFRC, MPP1, MPP2, CYBB

Molecular functions related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanylate kinase activityGO:00438510.0MPP2, MPP1

Products for genes affiliated with Ehrlichiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ehrlichiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet