HE
MCID: EHR002
MIFTS: 54

Ehrlichiosis (HE) malady

Infectious diseases category

Summaries for Ehrlichiosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including rash, fatigue and muscle aches. An important gene associated with Ehrlichiosis is MAP2 (microtubule-associated protein 2). The compounds succinylacetone and neopterin have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotype immune system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia:63 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Aliases & Classifications for Ehrlichiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
ehrlichiosis:
Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

ehrlichiosis 8 42 10 44 48 60
human ehrlichiosis 8 42 60
he 42


External Ids:

Disease Ontology8 DOID:10242
MeSH34 D016873
ICD9CM27 082.4, 082.40
MESH via Orphanet35 D016873
SNOMED-CT56 77361002
ICD10 via Orphanet26 A48.8
SNOMED-CT via Orphanet57 77361002
UMLS via Orphanet61 C0085399

Related Diseases for Ehrlichiosis

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17GeneCards, 18GeneDecks
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Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1human monocytic ehrlichiosis31.0MAP2, ECHS1, RGR, UCK2, MMP12
2human granulocytic anaplasmosis30.6SELPLG, RGR, FUT7, MMP12
3hepatitis30.0TFRC, GPT
4arthritis29.8IL18R1, MMP12, CXCL2
5malaria29.8MPP1, IL18R1, TFRC
6leukemia29.8CXCL2, IL18R1, TFRC, FUT7, SELPLG, CYBB
7lyme disease10.5
8babesiosis10.5
9rocky mountain spotted fever10.3
10spotted fever10.3
11encephalitis10.3
12tick-borne encephalitis10.2
13toxic shock syndrome10.1
14thrombocytopenia10.1
15tick infestation10.1
16hypereosinophilic syndrome10.1
17primary hypereosinophilic syndrome10.1
18body dysmorphic disorder10.0
19dysentery10.0
20hashimoto's encephalitis10.0
21lymphoid hypereosinophilic syndrome10.0
22secondary hypereosinophilic syndrome10.0
23tuberculosis10.0MPP1
24sickle cell disease10.0TFRC
25anaplastic large cell lymphoma10.0IL18R1
26pneumonia10.0MMP12, CXCL2
27celiac disease10.0MMP12, TFRC
28histiocytosis10.0FSCN2
29sarcoidosis10.0IL18R1, CYBB
30asthma10.0IL18R1, SELPLG, MMP12
31hereditary spherocytosis10.0TFRC, ANK1
32ischemia10.0SELPLG, MAP2, CXCL2
33rhyns syndrome10.0CYBB, FSCN2, RGR
34peritonitis10.0IL18R1, CXCL2, SELPLG
35cadasil10.0SELPLG, IL18R1, MAP2, MMP12
36multiple sclerosis10.0TFRC, IL18R1, MAP2, SELPLG, MMP12
37siderosis10.0TFRC, GPT
38atherosclerosis10.0CYBB, IL18R1, SELPLG, MMP12
39viral infectious disease10.0GPT, TFRC, IL18R1, CXCL2
40ipex syndrome10.0GPT, IL18R1, MAP2, MPP1, TFRC, TNFRSF9
41burkitt's lymphoma10.0MAP2, TFRC, MPP1, FUT7, TNFRSF9
42melanoma10.0MPP1, MAP2, CXCL2, TFRC, IL18R1, MMP12
43hemophagocytic lymphohistiocytosis9.9
44adult respiratory distress syndrome9.9
45tick paralysis9.9
46cat-scratch disease9.9
47sennetsu fever9.9
48q fever9.9
49cerebritis9.9
50chagas disease9.9

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Clinical Features for Ehrlichiosis

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8Disease Ontology
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Symptoms:

8
  • rash
  • fatigue
  • muscle aches
  • headache

Drugs & Therapeutics for Ehrlichiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ehrlichiosis

Drug clinical trials:

Search ClinicalTrials for Ehrlichiosis

Search NIH Clinical Center for Ehrlichiosis

Search CenterWatch for Ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Ehrlichiosis:

32
Monocytes, Testes, T cells, Bone marrow, Bone, Lung, Pancreas, B cells, Myeloid, Liver, Lymph node, Whole blood, Eye

FMA organs/tissues related to Ehrlichiosis:

14
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ehrlichiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.0FUT7, SELPLG, MMP12, IL18R1, CYBB, ANK1

Publications for Ehrlichiosis

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50PubMed
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Articles related to Ehrlichiosis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis. (23907060)
2013
2
Emergence of bovine ehrlichiosis in Belgian cattle herds. (21771546)
2011
3
Blood smear analysis in babesiosis, ehrlichiosis, relapsing fever, malaria, and Chagas disease. (18646588)
2008
4
Ocular manifestations of natural canine monocytic ehrlichiosis (Ehrlichia canis): a retrospective study of 90 cases. (17445073)
2007
5
Human ehrlichiosis: clinical and ecological challenges. (17713299)
2007
6
Toxoplasma gondii genotyping in a dog co-infected with distemper virus and ehrlichiosis rickettsia. (17221136)
2006
7
Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002. (16103612)
2005
8
In vivo and in vitro studies on Anaplasma phagocytophilum infection of the myeloid cells of a patient with chronic myelogenous leukaemia and human granulocytic ehrlichiosis. (15113857)
2004
9
Detection of pathogenic Ehrlichia in ticks collected at acquisition sites of human ehrlichiosis in Missouri. (15119113)
2004
10
Ehrlichiosis in anemic, thrombocytopenic, or tick-infested dogs from a hospital population in South Brazil. (14637030)
2003
11
Equine ehrlichiosis in Italy. (12860637)
2003
12
Molecular evidence of coinfection of Borrelia burgdorferi sensu lato, human granulocytic ehrlichiosis agent, and Babesia microti in ticks from northwestern Poland. (12659331)
2003
13
Human granulocytic ehrlichiosis as a common cause of tick-associated fever in Southeast Sweden: report from a prospective clinical study. (12030391)
2002
14
Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis. (12183586)
2002
15
Transcript heterogeneity of the p44 multigene family in a human granulocytic ehrlichiosis agent transmitted by ticks. (11854198)
2002
16
Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction. (11716122)
2001
17
Infection of mice with the agent of human granulocytic ehrlichiosis after different routes of inoculation. (11372031)
2001
18
Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis. (11450674)
2001
19
Evaluation of a polyvalent enzyme-linked immunosorbent assay incorporating a recombinant p44 antigen for diagnosis of granulocytic ehrlichiosis in dogs and horses. (11197555)
2001
20
Human monocytic ehrlichiosis: an emerging pathogen in transplantation. (11435982)
2001
21
Population-based incidence of human granulocytic ehrlichiosis in northwestern Wisconsin, 1997-1999. (11709792)
2001
22
Survival of the human granulocytic ehrlichiosis agent under refrigeration conditions. (10835014)
2000
23
Serologic evidence of human monocytic and granulocytic ehrlichiosis in israel (10827126)
2000
24
The agent of human granulocytic ehrlichiosis induces the production of myelosuppressing chemokines without induction of proinflammatory cytokines. (10882598)
2000
25
Seroprevalence of ehrlichiosis, Lyme borreliosis and tick-borne encephalitis infections in children and young adults in Slovenia. (11098535)
2000
26
Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. (10754283)
2000
27
First report of human granulocytic ehrlichiosis from southern Europe (Spain). (10905986)
2000
28
Canine ehrlichiosis caused simultaneously by Ehrlichia canis and Ehrlichia platys. (11092236)
2000
29
The emergence of another tickborne infection in the 12-town area around Lyme, Connecticut: human granulocytic ehrlichiosis. (10751139)
2000
30
Human granulocytic ehrlichiosis in Bulgaria. (9988323)
1999
31
Adaptation of the agent of the human monocyte ehrlichiosis (Ehrlichia chaffeensis) to HL60. (10348219)
1999
32
Serologic testing of horses for granulocytic ehrlichiosis, using indirect fluorescent antibody staining and immunoblot analysis. (10328436)
1999
33
Prevalence of antibodies against the human granulocytic ehrlichiosis agent in Lyme borreliosis patients from Germany. (10357060)
1999
34
A further case of acute human granulocytic ehrlichiosis in Slovenia. (10421051)
1999
35
Serological evidence of human granulocytic ehrlichiosis in Switzerland. (9665305)
1998
36
Characterization of monoclonal antibodies to the 44-kilodalton major outer membrane protein of the human granulocytic ehrlichiosis agent. (9774579)
1998
37
Geographic risk for lyme disease and human granulocytic ehrlichiosis in southern New York state. (9835546)
1998
38
Human granulocytic ehrlichiosis in Europe: clinical and laboratory findings for four patients from Slovenia. (9770134)
1998
39
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
40
Clinical features and serology of 14 dogs affected by granulocytic ehrlichiosis in Sweden. (9076917)
1997
41
Transmission of the agent of human granulocytic ehrlichiosis by host-seeking Ixodus scapularis (Acari:Ixodidae) in southern New York state. (9220669)
1997
42
Human granulocytic ehrlichiosis in a renal transplant patient: case report and review of the literature. (9355830)
1997
43
Human ehrlichiosis--Maryland, 1994. (8926996)
1996
44
Platelet dysfunction associated with experimental acute canine ehrlichiosis. (8890464)
1996
45
Exposure to deer blood may be a cause of human granulocytic ehrlichiosis. (8816164)
1996
46
Equine granulocytic ehrlichiosis in Connecticut caused by an agent resembling the human granulocytotropic ehrlichia. (8789032)
1996
47
Clinical and laboratory characteristics of human granulocytic ehrlichiosis. (8604172)
1996
48
Serum protein alterations in canine ehrlichiosis. (9017886)
1996
49
Human ehrlichiosis. (7591456)
1995
50
Human granulocytic ehrlichiosis in Europe. (7658904)
1995

Genetic Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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Compounds for genes affiliated with Ehrlichiosis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Ehrlichiosis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1succinylacetone4410.4CYBB, TFRC
2neopterin4410.3GPT, IL18R1, TFRC
3polylactosamine4410.2SELPLG, FUT7
4polysaccharide4410.1FUT7, SELPLG, IL18R1, TFRC
5n acetylcysteine4410.1TFRC, CXCL2, MMP12, GPT
6acridine4410.1TFRC, MPP2
7sialic acid4410.0FUT7, SELPLG, TFRC
8ethanol44 49 11 2413.0MAP2, CXCL2, IL18R1, GPT
9fibrinogen4410.0CXCL2, MMP12, GPT, SELPLG
10oxygen44 2410.9CYBB, CXCL2, IL18R1, MMP12, SELPLG
11vegf449.8TFRC, MAP2, CYBB, CXCL2, IL18R1, MMP12
12mannose 6-phosphate44 2410.7MPP2, MPP1, TFRC
13serine449.7MAP2, CYBB, CXCL2, IL18R1, MMP12, SELPLG
14dexamethasone44 49 28 1112.6TNFRSF9, TFRC, CYBB, CXCL2, IL18R1, MMP12
15glucose449.6MPP1, MPP2, MAP2, CYBB, IL18R1, GPT
16lipid449.6MPP1, ANK1, CXCL2, IL18R1, MMP12, GPT
17glycogen44 2410.4MPP2, MAP2, CXCL2, GPT
18tyrosine448.9SELPLG, NSUN5, TNFRSF9, TFRC, MPP1, ANK1

GO Terms for genes affiliated with Ehrlichiosis

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16Gene Ontology
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Cellular components related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stereociliumGO:03242010.1FSCN2, MPP1
2cortical cytoskeletonGO:0308639.8ANK1, MPP1
3integral to plasma membraneGO:0058879.1SELPLG, TNFRSF9, TFRC, MPP1, MPP2, CYBB

Molecular functions related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanylate kinase activityGO:00438510.0MPP2, MPP1

Products for genes affiliated with Ehrlichiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ehrlichiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet