MCID: EHR002
MIFTS: 39

Ehrlichiosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 50 56 52 42 14 69
Human Ehrlichiosis 12 50 3 69
He 50

Characteristics:

Orphanet epidemiological data:

56
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD10 33 A77.4 A77.40
ICD9CM 35 082.4 082.40
MeSH 42 D016873
SNOMED-CT 64 77361002
Orphanet 56 ORPHA1902
MESH via Orphanet 43 D016873
UMLS via Orphanet 70 C0085399
ICD10 via Orphanet 34 A48.8
UMLS 69 C0085399

Summaries for Ehrlichiosis

CDC : 3 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to spotted fever and malaria. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways/superpathways are Toxoplasmosis and Cell adhesion molecules (CAMs). Affiliated tissues include monocytes, testes and neutrophil, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia : 72 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 spotted fever 29.5 CD40LG HSPD1
2 malaria 28.1 CASP3 CD40LG SELP TFRC
3 human monocytic ehrlichiosis 12.3
4 human granulocytic anaplasmosis 11.7
5 tick infestation 11.1
6 sennetsu fever 10.8
7 lyme disease 10.2
8 babesiosis 10.2
9 hereditary amyloidosis 10.1 CD40LG SELP
10 mental depression 10.0 CD40LG SELP
11 hodgkin's lymphoma, nodular sclerosis 10.0 CASP3 CD40LG
12 retromolar area cancer 10.0 CD40LG SELP
13 pyridoxine deficiency 10.0 CD40LG SELPLG
14 rocky mountain spotted fever 10.0
15 hemophagocytic lymphohistiocytosis 9.9
16 encephalitis 9.9
17 tick-borne encephalitis 9.9
18 orbital melanoma 9.9 CASP3 HSPD1
19 thrombocytopenia 9.8
20 osteogenesis imperfecta, type vii 9.8 CD40LG SELP
21 chlamydia 9.7 CD40LG HSPD1
22 leiomyosarcoma 9.7 CD40LG HSPD1
23 pancytopenia 9.7
24 lymphoma 9.7
25 bartonellosis 9.7
26 meningitis 9.7
27 hepatitis 9.7
28 cerebritis 9.7
29 acute respiratory distress syndrome 9.7
30 pancreatic vasoactive intestinal peptide producing tumor 9.7 CD40LG HSPD1
31 basilar artery occlusion 9.6 CD40LG HSPD1
32 hypertrophic elongation of cervix 9.6 CD40LG RIT2
33 restless legs syndrome 9.6 CD40LG HSPD1
34 aseptic meningitis 9.5
35 colorado tick fever 9.5
36 relapsing fever 9.5
37 pancreatitis 9.5
38 diarrhea 9.5
39 demyelinating polyneuropathy 9.5
40 sensorineural hearing loss 9.5
41 coccidioidomycosis 9.5
42 pneumonia 9.5
43 pulmonary hypertension 9.5
44 thrombotic thrombocytopenic purpura 9.5
45 cholestasis 9.5
46 myocarditis 9.5
47 adult respiratory distress syndrome 9.5
48 q fever 9.5
49 polyneuropathy 9.5
50 appendicitis 9.5

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

MGI Mouse Phenotypes related to Ehrlichiosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 FUT7 SELP SELPLG TFRC ANK1 CASP3
2 cardiovascular system MP:0005385 9.91 ANK1 CASP3 CD40LG CYBB FUT7 SELP
3 immune system MP:0005387 9.86 ANK1 CASP3 CD40LG CYBB FUT7 SELP
4 integument MP:0010771 9.63 ANK1 CASP3 CD40LG SELP SELPLG TFRC
5 mortality/aging MP:0010768 9.61 ACO1 ANK1 CASP3 CD40LG CYBB HSPD1
6 renal/urinary system MP:0005367 9.1 ANK1 CASP3 CD40LG CYBB SELP SELPLG

Drugs & Therapeutics for Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

MalaCards organs/tissues related to Ehrlichiosis:

39
Monocytes, Testes, Neutrophil, T Cells, Liver, Bone, Bone Marrow

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 553)
id Title Authors Year
1
Therapeutic management of canine ehrlichiosis with aid of blood transfusion: a case report. ( 28615848 )
2017
2
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis. ( 28457353 )
2017
3
Cerebral haemorrhage as a clinical manifestation of human ehrlichiosis. ( 28751428 )
2017
4
Molecular prevalence and haemato-biochemical profile of canine monocytic ehrlichiosis in dogs in and around Hisar, Haryana, India. ( 28848253 )
2017
5
Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of Punjab. ( 28344412 )
2017
6
Ehrlichiosis ( 28722995 )
2017
7
High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. ( 28750787 )
2017
8
Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. ( 28628845 )
2017
9
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
10
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
11
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. ( 27633921 )
2016
12
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. ( 27308282 )
2016
13
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. ( 26918212 )
2016
14
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. ( 26621561 )
2016
15
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. ( 27388158 )
2016
16
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. ( 27575459 )
2016
17
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. ( 27088220 )
2016
18
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. ( 27097347 )
2016
19
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. ( 27876946 )
2016
20
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. ( 26621564 )
2016
21
Development of Structure-Based Vaccines for Ehrlichiosis. ( 27076151 )
2016
22
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. ( 27142117 )
2016
23
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. ( 26854345 )
2016
24
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. ( 26837859 )
2016
25
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. ( 27758794 )
2016
26
1217: EXTRACORPOREAL MEMBRANE OXYGENATION FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO EHRLICHIOSIS. ( 26570878 )
2015
27
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). ( 25770893 )
2015
28
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. ( 27065635 )
2015
29
Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in Southern Europe. ( 25561342 )
2015
30
Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data. ( 25756797 )
2015
31
The perils of country life: human monocytic ehrlichiosis. ( 25912197 )
2015
32
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. ( 26616656 )
2015
33
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. ( 26018824 )
2015
34
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. ( 26414283 )
2015
35
First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania. ( 25867940 )
2015
36
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. ( 25888870 )
2015
37
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). ( 25957922 )
2015
38
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. ( 25737562 )
2015
39
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. ( 26062723 )
2015
40
Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. ( 25449215 )
2015
41
Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. ( 25649069 )
2015
42
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. ( 26083691 )
2015
43
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. ( 25565883 )
2015
44
Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis. ( 24491580 )
2014
45
Vector-borne pathogens in dogs from Costa Rica: First molecular description of Babesia vogeli and Hepatozoon canis infections with a high prevalence of monocytic ehrlichiosis and the manifestations of co-infection. ( 24315693 )
2014
46
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. ( 25332563 )
2014
47
Sinus Bradycardia: Can We Blame Ehrlichiosis? ( 25232718 )
2014
48
An Animal Model of a Newly Emerging Human Ehrlichiosis. ( 24990203 )
2014
49
A novel Ehrlichia genotype strain distinguished by the TRP36 gene naturally infects cattle in Brazil and causes clinical manifestations associated with ehrlichiosis. ( 24915874 )
2014
50
Doxycycline desensitization for a suspected case of ehrlichiosis. ( 24565779 )
2014

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.6 CASP3 CD40LG CYBB
2 11.29 CD40LG SELP SELPLG
3 10.86 CYBB TFRC
4 9.7 ACO1 TFRC

GO Terms for Ehrlichiosis

Cellular components related to Ehrlichiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.28 ANK1 CASP3 CD40LG CYBB HSPD1 RIT2

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.32 CD40LG HSPD1
2 leukocyte cell-cell adhesion GO:0007159 9.26 CD40LG SELP
3 positive regulation of interleukin-12 production GO:0032735 9.16 CD40LG HSPD1
4 positive regulation of interleukin-10 production GO:0032733 8.96 CD40LG HSPD1
5 leukocyte tethering or rolling GO:0050901 8.62 SELP SELPLG

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 HSPD1 SELP

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....