MCID: EHR002
MIFTS: 45

Ehrlichiosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 72 49 55 51 41 14 69
Human Ehrlichiosis 12 49 3 69
He 49

Characteristics:

Orphanet epidemiological data:

55
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD10 32 A77.4 A77.40
ICD9CM 34 082.4 082.40
MeSH 41 D016873
SNOMED-CT 64 77361002
Orphanet 55 ORPHA1902
MESH via Orphanet 42 D016873
UMLS via Orphanet 70 C0085399
ICD10 via Orphanet 33 A48.8

Summaries for Ehrlichiosis

CDC : 3 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human granulocytic anaplasmosis and bartonellosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways/superpathways are Toxoplasmosis and Cell adhesion molecules (CAMs). Affiliated tissues include leukocyte, monocytes and testes, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia : 72 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 human granulocytic anaplasmosis 31.2 ANK1 CD40LG CYBB FUT7 HSPD1 SELPLG
2 bartonellosis 29.6 CD40LG HSPD1
3 cat-scratch disease 29.4 CD40LG HSPD1
4 malaria 28.7 CASP3 CD40LG SELP TFRC
5 human monocytic ehrlichiosis 12.4
6 tick infestation 11.3
7 sennetsu fever 10.9
8 lyme disease 10.3
9 babesiosis 10.3
10 heparin-induced thrombocytopenia 10.2 CD40LG SELP
11 thrombocytopenia due to platelet alloimmunization 10.2 CD40LG SELP
12 primary thrombocytopenia 10.2 CD40LG SELP
13 legg-calve-perthes disease 10.2 CD40LG SELP
14 hemorrhagic fever 10.1 CD40LG TFRC
15 pustulosis palmaris et plantaris 10.1 CD40LG SELPLG
16 heterophyiasis 10.1 CASP3 CD40LG
17 rocky mountain spotted fever 10.1
18 spotted fever 10.1
19 anemia, sideroblastic, 1 10.0 ACO1 TFRC
20 hemophagocytic lymphohistiocytosis 10.0
21 encephalitis 10.0
22 gray platelet syndrome 10.0 CD40LG SELP
23 tick-borne encephalitis 10.0
24 fallopian tube disease 10.0 CD40LG HSPD1
25 salpingitis 10.0 CD40LG HSPD1
26 urethritis 9.9 CD40LG HSPD1
27 thrombocytopenia 9.9
28 endocardium disease 9.9 CD40LG HSPD1
29 carrion's disease 9.8 CD40LG HSPD1
30 lymphoma, non-hodgkin, familial 9.8 CASP3 CD40LG TFRC
31 hepatitis 9.8
32 lymphoma 9.8
33 pancytopenia 9.8
34 cerebritis 9.8
35 meningitis 9.8
36 acute respiratory distress syndrome 9.8
37 pelvic inflammatory disease 9.8 CD40LG HSPD1
38 idiopathic neutropenia 9.7 CASP3 CD40LG
39 atrial standstill 1 9.6
40 dermal ridges-off-the-end 9.6
41 kala-azar 1 9.6
42 episodic pain syndrome, familial, 1 9.6
43 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.6
44 multiple mitochondrial dysfunctions syndrome 5 9.6
45 pulmonary hypertension 9.6
46 adult respiratory distress syndrome 9.6
47 arthritis 9.6
48 b-cell lymphomas 9.6
49 leukemia 9.6
50 neutropenia 9.6

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

Symptoms:

12
  • headache
  • muscle aches
  • fatigue
  • rash

MGI Mouse Phenotypes related to Ehrlichiosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 ANK1 CASP3 CD40LG CYBB FUT7 SELP
2 cardiovascular system MP:0005385 9.91 ANK1 CASP3 CD40LG CYBB FUT7 SELP
3 immune system MP:0005387 9.86 CD40LG CYBB FUT7 SELP SELPLG TFRC
4 integument MP:0010771 9.63 ANK1 CASP3 CD40LG SELP SELPLG TFRC
5 mortality/aging MP:0010768 9.61 ACO1 ANK1 CASP3 CD40LG CYBB HSPD1
6 renal/urinary system MP:0005367 9.1 ANK1 CASP3 CD40LG CYBB SELP SELPLG

Drugs & Therapeutics for Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

The Foundational Model of Anatomy Ontology organs/tissues related to Ehrlichiosis:

18
Leukocyte

MalaCards organs/tissues related to Ehrlichiosis:

38
Monocytes, Testes, T Cells, Neutrophil, Bone Marrow, Bone, Liver

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 555)
# Title Authors Year
1
Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States. ( 29350157 )
2018
2
High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. ( 28750787 )
2017
3
Therapeutic management of canine ehrlichiosis with aid of blood transfusion: a case report. ( 28615848 )
2017
4
Molecular prevalence and haemato-biochemical profile of canine monocytic ehrlichiosis in dogs in and around Hisar, Haryana, India. ( 28848253 )
2017
5
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis. ( 28457353 )
2017
6
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
7
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
8
Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of Punjab. ( 28344412 )
2017
9
Canine Monocytic Ehrlichiosis among working dogs of organised kennels in India: A comprehensive analyses of clinico-pathology, serological and molecular epidemiological approach. ( 29254723 )
2017
10
Ehrlichiosis ( 28722995 )
2017
11
Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. ( 28628845 )
2017
12
Cerebral haemorrhage as a clinical manifestation of human ehrlichiosis. ( 28751428 )
2017
13
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. ( 26918212 )
2016
14
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. ( 27758794 )
2016
15
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. ( 27575459 )
2016
16
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. ( 27088220 )
2016
17
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. ( 26621564 )
2016
18
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. ( 26854345 )
2016
19
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. ( 26621561 )
2016
20
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. ( 27876946 )
2016
21
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. ( 27097347 )
2016
22
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. ( 27633921 )
2016
23
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. ( 27142117 )
2016
24
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. ( 27308282 )
2016
25
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. ( 27388158 )
2016
26
Development of Structure-Based Vaccines for Ehrlichiosis. ( 27076151 )
2016
27
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. ( 26837859 )
2016
28
Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. ( 25649069 )
2015
29
The perils of country life: human monocytic ehrlichiosis. ( 25912197 )
2015
30
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). ( 25957922 )
2015
31
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. ( 26018824 )
2015
32
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. ( 25737562 )
2015
33
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. ( 27065635 )
2015
34
1217: EXTRACORPOREAL MEMBRANE OXYGENATION FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO EHRLICHIOSIS. ( 26570878 )
2015
35
Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. ( 25449215 )
2015
36
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. ( 26083691 )
2015
37
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. ( 25565883 )
2015
38
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). ( 25770893 )
2015
39
Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data. ( 25756797 )
2015
40
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. ( 26616656 )
2015
41
Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in Southern Europe. ( 25561342 )
2015
42
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. ( 26414283 )
2015
43
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. ( 25888870 )
2015
44
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. ( 26062723 )
2015
45
First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania. ( 25867940 )
2015
46
Doxycycline desensitization for a suspected case of ehrlichiosis. ( 24565779 )
2014
47
A novel Ehrlichia genotype strain distinguished by the TRP36 gene naturally infects cattle in Brazil and causes clinical manifestations associated with ehrlichiosis. ( 24915874 )
2014
48
Acute respiratory distress syndrome in human granulocytic ehrlichiosis. ( 25672061 )
2014
49
Clinical history and hematological findings among canines with monocytic ehrlichiosis. ( 24964665 )
2014
50
Intracytoplasmic granulocytic morulae counts on confirmed cases of ehrlichiosis/anaplasmosis in the Northeast. ( 24713739 )
2014

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.6 CASP3 CD40LG CYBB
2 11.29 CD40LG SELP SELPLG
3 10.86 CYBB TFRC
4 9.7 ACO1 TFRC

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.32 CD40LG HSPD1
2 leukocyte cell-cell adhesion GO:0007159 9.26 CD40LG SELP
3 positive regulation of interleukin-12 production GO:0032735 9.16 CD40LG HSPD1
4 positive regulation of interleukin-10 production GO:0032733 8.96 CD40LG HSPD1
5 leukocyte tethering or rolling GO:0050901 8.62 SELP SELPLG

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 HSPD1 SELP

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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