HE
MCID: EHR002
MIFTS: 38

Ehrlichiosis (HE) malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Ehrlichiosis

About this section
Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ehrlichiosis:

Name: Ehrlichiosis 11 48 54 50 39 13 68
Human Ehrlichiosis 11 48 2 68
 
He 48

Characteristics:

Orphanet epidemiological data:

54
ehrlichiosis:
Prevalence: 1-9/1000000 (United States); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:10242
ICD1030 A77.4, A77.40
ICD9CM32 082.4, 082.40
MeSH39 D016873
SNOMED-CT62 77361002
Orphanet54 ORPHA1902
MESH via Orphanet40 D016873
UMLS via Orphanet69 C0085399
ICD10 via Orphanet31 A48.8

Summaries for Ehrlichiosis

About this section
CDC:2 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards based summary: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is SELPLG (Selectin P Ligand), and among its related pathways are amb2 Integrin signaling and Iron metabolism in placenta. Affiliated tissues include leukocyte, monocytes and testes.

Disease Ontology:11 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia:71 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

About this section

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

About this section

Symptoms:

 11 (show all 4)
  • headache
  • muscle aches
  • fatigue
  • rash

Drugs & Therapeutics for Ehrlichiosis

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ehrlichiosis


Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

About this section

Anatomical Context for Ehrlichiosis

About this section

MalaCards organs/tissues related to Ehrlichiosis:

36
Monocytes, Testes, T cells, Neutrophil, Bone marrow, Bone, Liver

FMA organs/tissues related to Ehrlichiosis:

17
Leukocyte

Publications for Ehrlichiosis

About this section

Articles related to Ehrlichiosis:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. (28518034)
2017
2
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. (27142117)
2016
3
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. (26621561)
2016
4
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. (27308282)
2016
5
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. (27088220)
2016
6
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. (27633921)
2016
7
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. (26854345)
2016
8
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. (27575459)
2016
9
Development of Structure-Based Vaccines for Ehrlichiosis. (27076151)
2016
10
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. (27876946)
2016
11
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. (26837859)
2016
12
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. (26621564)
2016
13
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. (27097347)
2016
14
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. (26918212)
2016
15
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. (27388158)
2016
16
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. (27758794)
2016
17
Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. (25649069)
2015
18
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. (26083691)
2015
19
Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. (25449215)
2015
20
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. (26414283)
2015
21
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. (25888870)
2015
22
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). (25957922)
2015
23
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). (25770893)
2015
24
First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania. (25867940)
2015
25
The perils of country life: human monocytic ehrlichiosis. (25912197)
2015
26
Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in Southern Europe. (25561342)
2015
27
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. (25565883)
2015
28
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. (26616656)
2015
29
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. (27065635)
2015
30
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. (25737562)
2015
31
Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data. (25756797)
2015
32
1217: EXTRACORPOREAL MEMBRANE OXYGENATION FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO EHRLICHIOSIS. (26570878)
2015
33
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. (26018824)
2015
34
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. (26062723)
2015
35
Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis. (24491580)
2014
36
Bayesian spatio-temporal analysis and geospatial risk factors of human monocytic ehrlichiosis. (24992684)
2014
37
Acute respiratory distress syndrome in human granulocytic ehrlichiosis. (25672061)
2014
38
Usefulness of a rapid immuno-migration test for the detection of canine monocytic ehrlichiosis in Africa. (24252768)
2014
39
Vector-borne pathogens in dogs from Costa Rica: First molecular description of Babesia vogeli and Hepatozoon canis infections with a high prevalence of monocytic ehrlichiosis and the manifestations of co-infection. (24315693)
2014
40
Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis in a Child. (24691079)
2014
41
Intracytoplasmic granulocytic morulae counts on confirmed cases of ehrlichiosis/anaplasmosis in the Northeast. (24713739)
2014
42
An Animal Model of a Newly Emerging Human Ehrlichiosis. (24990203)
2014
43
A case of human monocytic ehrlichiosis in Serbia. (24684037)
2014
44
Doxycycline desensitization for a suspected case of ehrlichiosis. (24565779)
2014
45
Serum canine pancreatic lipase immunoreactivity in experimentally induced and naturally occurring canine monocytic ehrlichiosis (Ehrlichia canis). (24530039)
2014
46
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. (25332563)
2014
47
Clinical history and hematological findings among canines with monocytic ehrlichiosis. (24964665)
2014
48
A novel Ehrlichia genotype strain distinguished by the TRP36 gene naturally infects cattle in Brazil and causes clinical manifestations associated with ehrlichiosis. (24915874)
2014
49
Sinus Bradycardia: Can We Blame Ehrlichiosis? (25232718)
2014
50
Social-ecological factors determine spatial variation in human incidence of tick-borne ehrlichiosis. (24280291)
2013

Variations for Ehrlichiosis

About this section

Expression for genes affiliated with Ehrlichiosis

About this section
Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

About this section

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9SELP, SELPLG
29.9ACO1, TFRC
39.8CYBB, TFRC

GO Terms for genes affiliated with Ehrlichiosis

About this section

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:005090110.5SELP, SELPLG
2response to lipopolysaccharideGO:00324969.3CASP3, HSPD1, SELP

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.7HSPD1, SELP

Sources for Ehrlichiosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet