MCID: EHR002
MIFTS: 45

Ehrlichiosis malady

Rare diseases, Infectious diseases, Blood diseases categories

Aliases & Classifications for Ehrlichiosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 3CDC, 33MeSH, 27ICD9CM, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Ehrlichiosis, Aliases & Descriptions:

Name: Ehrlichiosis 9 41 11 43 47 60
Human Ehrlichiosis 9 41 3 60
 
He 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
ehrlichiosis:
Prevalence: 1-9/1000000 (United States); Age of onset: All ages


External Ids:

Disease Ontology9 DOID:10242
MeSH33 D016873
ICD9CM27 082.40, 082.4
Orphanet47 1902
SNOMED-CT55 77361002
MESH via Orphanet34 D016873
ICD10 via Orphanet26 A48.8
UMLS via Orphanet61 C0085399

Summaries for Ehrlichiosis

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Disease Ontology:9 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is MAP2 (microtubule-associated protein 2), and among its related pathways are Phagosome and HIF-1 signaling pathway. The compounds nocodazole and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotypes are nervous system and hematopoietic system.

Wikipedia:63 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

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Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1human monocytic ehrlichiosis31.1MMP12, MAP2, RGR
2human granulocytic anaplasmosis30.6RGR, MMP12, SELPLG
3leukemia29.3SELPLG, CYBB, TFRC
4lyme disease10.6
5babesiosis10.6
6rocky mountain spotted fever10.3
7encephalitis10.3
8spotted fever10.3
9tick-borne encephalitis10.3
10hemophagocytic lymphohistiocytosis10.2
11thrombocytopenia10.2
12tick infestation10.2
13celiac disease10.1MMP12, TFRC
14amyotrophic lateral sclerosis 110.1MAP2, TFRC
15hepatitis10.1
16acute respiratory distress syndrome10.1
17cork-handlers' disease10.1TFRC, MMP12
18pulmonary disease, chronic obstructive10.1MMP12, SELPLG
19vascular disease10.1MAP2, SELPLG
20brain cancer10.1MAP2, TFRC
21retinitis pigmentosa autosomal recessive10.0RGR, CYBB
22small cell cancer of the lung, somatic10.0MAP2, SELPLG
23malignant glioma9.9MAP2, MMP12, TFRC
24malaria9.9
25adult respiratory distress syndrome9.9
26arthritis9.9
27b-cell lymphomas9.9
28neutropenia9.9
29thrombotic thrombocytopenic purpura9.9
30appendicitis9.9
31tick paralysis9.9
32cat-scratch disease9.9
33coccidioidomycosis9.9
34sennetsu fever9.9
35q fever9.9
36cerebritis9.9
37chagas disease9.9
38pancytopenia9.9
39colorado tick fever9.9
40angioedema9.9
41cholestasis9.9
42demyelinating polyneuropathy9.9
43diarrhea9.9
44histoplasmosis9.9
45hypothyroidism9.9
46lactic acidosis9.9
47leishmaniasis9.9
48meningitis9.9
49myocarditis9.9
50nephrotic syndrome9.9

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Symptoms for Ehrlichiosis

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Symptoms:

 9
  • headache
  • muscle aches
  • fatigue
  • rash

Drugs & Therapeutics for Ehrlichiosis

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Drug clinical trials:

Search ClinicalTrials for Ehrlichiosis

Search NIH Clinical Center for Ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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MalaCards organs/tissues related to Ehrlichiosis:

31
Monocytes, Testes, T cells, Neutrophil, Bone marrow, Bone, Eye, Whole blood, Lymph node, Liver, Lung, Pancreas, Myeloid, B cells

FMA organs/tissues related to Ehrlichiosis:

14
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

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MGI Mouse Phenotypes related to Ehrlichiosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2MAP2, MMP12, CYBB, TFRC
2MP:00053977.9MMP12, SELPLG, CYBB, TFRC
3MP:00053877.7TFRC, CYBB, SELPLG, MMP12

Publications for Ehrlichiosis

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Articles related to Ehrlichiosis:

(show top 50)    (show all 515)
idTitleAuthorsYear
1
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. (25888870)
2015
2
Sinus Bradycardia: Can We Blame Ehrlichiosis? (25232718)
2014
3
Prevalence of borreliosis, anaplasmosis, ehrlichiosis and Dirofilaria immitis in dogs and vectors in Voronezh Reserve (Russia). (24054985)
2013
4
Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis. (24144475)
2013
5
Social-ecological factors determine spatial variation in human incidence of tick-borne ehrlichiosis. (24280291)
2013
6
Serum acute phase proteins as clinical phase indicators and outcome predictors in naturally occurring canine monocytic ehrlichiosis. (21564293)
2011
7
Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. (21108506)
2010
8
Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia. (19018569)
2009
9
The importance of early treatment with doxycycline in human ehrlichiosis. (18344803)
2008
10
Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis. (17562770)
2007
11
Two cases of human granulocytic ehrlichiosis in Sardinia, Italy confirmed by PCR. (17114774)
2006
12
Surveys on seroprevalence of canine monocytic ehrlichiosis among dogs living in the Ivory Coast and Gabon and evaluation of a quick commercial test kit dot-ELISA. (17114755)
2006
13
Bone marrow mastocytosis in dogs with myelosuppressive monocytic ehrlichiosis (Ehrlichia canis): a retrospective study. (16967415)
2006
14
Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. (14742542)
2004
15
Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. (14734762)
2004
16
Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. (12817434)
2003
17
Comparison of patients fulfilling criteria for confirmed and probable human granulocytic ehrlichiosis. (12860648)
2003
18
Evaluation of cytology in the diagnosis of acute canine monocytic ehrlichiosis (Ehrlichia canis): a comparison between five methods. (12458168)
2003
19
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
20
Ehrlichiosis in Ixodes ricinus and wild mammals. (12141732)
2002
21
Granulocytic ehrlichiosis in Swedish dogs and horses. (12141731)
2002
22
Serologic evidence of ehrlichiosis among humans and wild animals in The Netherlands. (11915850)
2002
23
Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction. (11716122)
2001
24
Molecular typing of the etiologic agent of human granulocytic ehrlichiosis. (11526190)
2001
25
Serologic evidence of human monocytic and granulocytic ehrlichiosis in Israel. (10827125)
2000
26
Human granulocytic ehrlichiosis agent infection in a pony vaccinated with a Borrelia burgdorferi recombinant OspA vaccine and challenged by exposure to naturally infected ticks. (10618280)
2000
27
Survival of the human granulocytic ehrlichiosis agent under refrigeration conditions. (10835014)
2000
28
A simian model of human granulocytic ehrlichiosis. (10403332)
1999
29
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. (10225882)
1999
30
Human granulocytic ehrlichiosis in Northern California: two case descriptions with genetic analysis of the Ehrlichiae. (10476747)
1999
31
Recurrent human granulocytic ehrlichiosis and Lyme disease. (10383360)
1999
32
Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry. (9725558)
1998
33
Immunoserologic evidence of Human Granulocytic Ehrlichiosis in Danish patients with Lyme neuroborreliosis. (9730306)
1998
34
Serologic evidence of a natural infection of white-tailed deer with the agent of human granulocytic ehrlichiosis in Wisconsin and Maryland. (9801331)
1998
35
Granulocytic ehrlichiosis: an emerging or rediscovered tick-borne disease? (9879965)
1998
36
Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: evaluation of a 6-week course. (9650986)
1998
37
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. (9455892)
1998
38
Detection of the agent of human granulocytic ehrlichiosis (HGE) in UK ticks using polymerase chain reaction. (10030718)
1998
39
Serological evidence of human granulocytic ehrlichiosis in Switzerland. (9665305)
1998
40
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
41
Characterization of an immunoreactive protein from the agent of human granulocytic ehrlichiosis. (9114402)
1997
42
Human ehrlichiosis--Maryland, 1994. (8926996)
1996
43
A human case of monocytic ehrlichiosis with adult respiratory distress syndrome in northern California. (8764635)
1996
44
Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. (8748270)
1996
45
Human ehrlichiosis in the United States. (8714253)
1996
46
Apoptosis of gamma/delta T cells in human ehrlichiosis. (8623774)
1996
47
Human ehrlichiosis. (7591456)
1995
48
Ehrlichiosis in Belgium. (7475691)
1995
49
Human ehrlichiosis in a liver transplant recipient. (7482752)
1995
50
From the Centers for Disease Control and Prevention. Human granulocytic ehrlichiosis--New York, 1995. (7674488)
1995

Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CYBB, TFRC
29.1CYBB, TFRC

Compounds for genes affiliated with Ehrlichiosis

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Compounds related to Ehrlichiosis according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1nocodazole43 1210.8MAP2, TFRC
2ionomycin439.5TFRC, MAP2
3sialic acid439.5TFRC, SELPLG
4carbohydrates439.4SELPLG, TFRC
5succinylacetone439.4CYBB, TFRC
6phorbol-12-myristate439.4TFRC, CYBB
7okadaic acid43 5910.2MAP2, CYBB
8phosphatidylinositol439.2TFRC, MMP12, MAP2
9vitamin a43 24 1211.2RGR, TFRC
10dmso439.0TFRC, CYBB, MAP2
11h2o2439.0MAP2, CYBB, TFRC
12phosphatidylserine43 28 1210.9SELPLG, CYBB
13nitric oxide43 24 1210.9MAP2, MMP12, CYBB
14retinoic acid43 249.8MAP2, CYBB, TFRC
15vegf438.5TFRC, CYBB, MMP12, MAP2
16oxygen43 249.4MAP2, MMP12, SELPLG, CYBB
17dexamethasone43 49 28 1211.3MMP12, SELPLG, CYBB, TFRC
18serine437.9MAP2, MMP12, SELPLG, CYBB, TFRC
19tyrosine437.9TFRC, CYBB, SELPLG, MMP12, MAP2

GO Terms for genes affiliated with Ehrlichiosis

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Cellular components related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.1RGR, SELPLG, CYBB, TFRC

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.6RGR, MAP2, SELPLG, CYBB, TFRC

Products for genes affiliated with Ehrlichiosis

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  • Antibodies
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  • Kits and Assays

Sources for Ehrlichiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet