MCID: EHR002
MIFTS: 44

Ehrlichiosis malady

Categories: Rare diseases, Infectious diseases, Blood diseases

Aliases & Classifications for Ehrlichiosis

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 37MeSH, 66UMLS, 2CDC, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Ehrlichiosis:

Name: Ehrlichiosis 11 46 13 52 48 37 66
Human Ehrlichiosis 11 46 2 66
 
He 46

Characteristics:

Orphanet epidemiological data:

52
ehrlichiosis:
Prevalence: 1-9/1000000 (United States); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:10242
ICD1028 A77.4, A77.40
ICD9CM30 082.4, 082.40
MeSH37 D016873
SNOMED-CT60 77361002
Orphanet52 ORPHA1902
ICD10 via Orphanet29 A48.8
MESH via Orphanet38 D016873
UMLS via Orphanet67 C0085399

Summaries for Ehrlichiosis

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Disease Ontology:11 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary: Ehrlichiosis, also known as human ehrlichiosis, is related to spotted fever and human monocytic ehrlichiosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is SELPLG (Selectin P Ligand), and among its related pathways are Iron metabolism in placenta and Cell adhesion molecules (CAMs). Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotypes are integument and renal/urinary system.

Wikipedia:69 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

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Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1spotted fever30.2CD40LG, HSPD1
2human monocytic ehrlichiosis12.3
3human granulocytic anaplasmosis11.7
4sennetsu fever10.9
5tick infestation10.5
6lyme disease10.3
7babesiosis10.3
8parasitic helminthiasis infectious disease10.3CASP3, CD40LG
9loin pain hematuria syndrome10.2CD40LG, SELPLG
10stickler sydrome, type i, nonsyndromic ocular10.1CD40LG, SELP
11atrophic gastritis10.1CD40LG, SELP
12ornithosis10.1CD40LG, HSPD1
13rocky mountain spotted fever10.1
14fallopian tube leiomyosarcoma10.1CD40LG, HSPD1
15small intestinal vasoactive intestinal peptide producing tumor10.1CD40LG, HSPD1
16typhus10.1ACO1, TFRC
17hemophagocytic lymphohistiocytosis10.0
18encephalitis10.0
19tick-borne encephalitis10.0
20restless legs syndrome10.0CD40LG, HSPD1
21retroperitoneal fibrosis10.0CASP3, CD40LG
22gray platelet syndrome10.0CD40LG, SELP
23gemistocytic astrocytoma9.9CASP3, CD40LG, SELP
24thrombocytopenia9.9
25bile duct signet ring cell carcinoma9.9CD40LG, HSPD1
26phagocyte bactericidal dysfunction9.8CASP3, HSPD1, SELP
27hepatitis9.8
28lymphoma9.8
29bartonellosis9.8
30meningitis9.8
31acute respiratory distress syndrome9.8
32platelet storage pool deficiency9.7CD40LG, SELP
33malaria9.7
34pulmonary hypertension9.7
35adult respiratory distress syndrome9.7
36arthritis9.7
37b-cell lymphomas9.7
38leukemia9.7
39neutropenia9.7
40thrombotic thrombocytopenic purpura9.7
41q fever9.7
42respiratory failure9.7
43cat-scratch disease9.7
44tick paralysis9.7
45nephrotic syndrome9.7
46optic neuritis9.7
47chagas disease9.7
48aseptic meningitis9.7
49pancytopenia9.7
50relapsing fever9.7

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Symptoms for Ehrlichiosis

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Symptoms:

 11
  • h
  • m
  • f
  • r

Drugs & Therapeutics for Ehrlichiosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ehrlichiosis


Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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MalaCards organs/tissues related to Ehrlichiosis:

34
Monocytes, Testes, T cells, Neutrophil, Bone marrow, Bone, Liver

FMA organs/tissues related to Ehrlichiosis:

17
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

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MGI Mouse Phenotypes related to Ehrlichiosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.7ANK1, CASP3, CD40LG, SELP, SELPLG, TFRC
2MP:00053677.9ANK1, CASP3, CD40LG, CYBB, SELP, SELPLG
3MP:00053847.3CASP3, CD40LG, FAM161A, FUT7, HSPD1, SELP
4MP:00053877.2ANK1, CASP3, CD40LG, CYBB, FAM161A, FUT7
5MP:00107687.1ACO1, ANK1, CASP3, CD40LG, CYBB, HSPD1
6MP:00053977.1ANK1, CASP3, CD40LG, CYBB, FAM161A, FUT7
7MP:00053857.0ANK1, CASP3, CD40LG, CYBB, FAM161A, FUT7
8MP:00036316.2ANK1, CASP3, CD40LG, CYBB, FAM161A, FSCN2

Publications for Ehrlichiosis

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Articles related to Ehrlichiosis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. (25888870)
2015
2
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. (26083691)
2015
3
Sinus Bradycardia: Can We Blame Ehrlichiosis? (25232718)
2014
4
An Animal Model of a Newly Emerging Human Ehrlichiosis. (24990203)
2014
5
Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis. (24144475)
2013
6
Serum acute phase proteins as clinical phase indicators and outcome predictors in naturally occurring canine monocytic ehrlichiosis. (21564293)
2011
7
Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. (21108506)
2010
8
Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia. (19018569)
2009
9
Clinical relevance of annual screening using a commercial enzyme-linked immunosorbent assay (SNAP 3Dx) for canine ehrlichiosis. (19411647)
2009
10
Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis. (19805532)
2009
11
The importance of early treatment with doxycycline in human ehrlichiosis. (18344803)
2008
12
Sequence and phylogenetic analysis of the 16S rRNA gene of Ehrlichia canis strains in dogs with clinical monocytic ehrlichiosis. (17624694)
2007
13
Two cases of human granulocytic ehrlichiosis in Sardinia, Italy confirmed by PCR. (17114774)
2006
14
Surveys on seroprevalence of canine monocytic ehrlichiosis among dogs living in the Ivory Coast and Gabon and evaluation of a quick commercial test kit dot-ELISA. (17114755)
2006
15
Validation of chemoprevention of canine monocytic ehrlichiosis with doxycycline. (15863288)
2005
16
Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. (14742542)
2004
17
Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. (12817434)
2003
18
Ehrlichiosis in anemic, thrombocytopenic, or tick-infested dogs from a hospital population in South Brazil. (14637030)
2003
19
Polymerase chain reaction in detection of human granulocytic ehrlichiosis (HGE) agent DNA in Ixodes ricinus ticks. (15232900)
2003
20
Ehrlichiosis in Ixodes ricinus and wild mammals. (12141732)
2002
21
Granulocytic ehrlichiosis in Swedish dogs and horses. (12141731)
2002
22
PCR detection of Borrelia burgdorferi sensu lato, tick-borne encephalitis virus, and the human granulocytic ehrlichiosis agent in Ixodes persulcatus ticks from Western Siberia, Russia. (12354885)
2002
23
Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction. (11716122)
2001
24
Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. (11560261)
2001
25
Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. (11247709)
2001
26
Ehrlichiosis associated vasculitis. (10886489)
2000
27
Human granulocytic ehrlichiosis in Northern California: two case descriptions with genetic analysis of the Ehrlichiae. (10476747)
1999
28
Infection of laboratory mice with the human granulocytic ehrlichiosis agent does not induce antibodies to diagnostically significant Borrelia burgdorferi antigens. (10325386)
1999
29
Epidemiological aspects of human granulocytic Ehrlichiosis in southern Germany. (10666819)
1999
30
Fine structural characterisation of a Rickettsia-like organism in human platelets from patients with symptoms of ehrlichiosis. (10535642)
1999
31
Ehrlichiosis with severe pulmonary manifestations despite early treatment. (10094281)
1999
32
Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry. (9725558)
1998
33
Immunoserologic evidence of Human Granulocytic Ehrlichiosis in Danish patients with Lyme neuroborreliosis. (9730306)
1998
34
Serologic evidence of a natural infection of white-tailed deer with the agent of human granulocytic ehrlichiosis in Wisconsin and Maryland. (9801331)
1998
35
Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: evaluation of a 6-week course. (9650986)
1998
36
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. (9455892)
1998
37
Detection of the agent of human granulocytic ehrlichiosis (HGE) in UK ticks using polymerase chain reaction. (10030718)
1998
38
Update: human ehrlichiosis--Maryland and Wisconsin, 1994. (9656961)
1998
39
Saddleback fever due to human granulocytic ehrlichiosis. (9500331)
1998
40
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
41
Positive Lyme disease serology in patients with clinical and laboratory evidence of human granulocytic ehrlichiosis. (9024062)
1997
42
Human ehrlichiosis--Maryland, 1994. (8926996)
1996
43
Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. (8748270)
1996
44
Human ehrlichiosis in the United States. (8714253)
1996
45
False-positive Lyme disease serology in human granulocytic ehrlichiosis. (8598802)
1996
46
The interface between research and the diagnosis of an emerging tick-borne disease, human ehrlichiosis due to Ehrlichia chaffeensis. (8546547)
1996
47
Central nervous system manifestations of human ehrlichiosis. (8842270)
1996
48
Post-therapy antibody titers in dogs with ehrlichiosis: follow-up study on 68 patients treated primarily with tetracycline and/or doxycycline. (8819054)
1996
49
Ehrlichiosis in Belgium. (7475691)
1995
50
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992

Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8ACO1, TFRC
29.4CD40LG, SELP, SELPLG

GO Terms for genes affiliated with Ehrlichiosis

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Cellular components related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.5CD40LG, SELP, TFRC
2integral component of plasma membraneGO:00058878.4CD40LG, CYBB, RGR, SELP, SELPLG, TFRC

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:000715910.1CD40LG, SELP
2positive regulation of interleukin-12 productionGO:00327359.9CD40LG, HSPD1
3positive regulation of interleukin-10 productionGO:00327339.9CD40LG, HSPD1
4B cell proliferationGO:00421009.9CD40LG, HSPD1
5response to organic cyclic compoundGO:00140709.3CASP3, HSPD1, SELP
6response to lipopolysaccharideGO:00324969.2CASP3, HSPD1, SELP
7response to hypoxiaGO:00016668.9CASP3, HSPD1, TFRC
8visual perceptionGO:00076018.7FAM161A, FSCN2, RGR

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.6HSPD1, SELP

Sources for Ehrlichiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet