HE
MCID: EHR002
MIFTS: 46

Ehrlichiosis (HE) malady

Infectious category

Summaries for Ehrlichiosis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including headache, fatigue and rash. An important gene associated with Ehrlichiosis is MAP2 (microtubule-associated protein 2). The compounds succinylacetone and neopterin have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, and related mouse phenotype immune system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia:64 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Aliases & Classifications for Ehrlichiosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
ehrlichiosis:
Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

ehrlichiosis 8 43 10 45 49 61
human ehrlichiosis 8 43 61
he 43


External Ids:

Disease Ontology8 DOID:10242
MeSH35 D016873
ICD9CM27 082.4, 082.40
MESH via Orphanet36 D016873
SNOMED-CT57 77361002
ICD10 via Orphanet26 A48.8
SNOMED-CT via Orphanet58 77361002
UMLS via Orphanet62 C0085399

Related Diseases for Ehrlichiosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1human monocytic ehrlichiosis31.1MAP2, ECHS1, RGR, UCK2, MMP12
2human granulocytic anaplasmosis30.7SELPLG, RGR, FUT7, MMP12
3arthritis29.9IL18R1, MMP12, CXCL2
4lyme disease10.6
5babesiosis10.5
6hypereosinophilic syndrome10.5
7rocky mountain spotted fever10.4
8spotted fever10.4
9tick-borne encephalitis10.3
10toxic shock syndrome10.2
11thrombocytopenia10.2
12mini stroke10.1
13secondary hypereosinophilic syndrome10.1
14primary hypereosinophilic syndrome10.1
15n syndrome10.1
16tick infestation10.1
17body dysmorphic disorder10.1
18hashimoto's encephalitis10.1
19lymphoid hypereosinophilic syndrome10.1
20tuberculosis10.0MPP1
21sickle cell disease10.0TFRC
22anaplastic large cell lymphoma10.0IL18R1
23pneumonia10.0MMP12, CXCL2
24celiac disease10.0MMP12, TFRC
25histiocytosis10.0FSCN2
26sarcoidosis10.0IL18R1, CYBB
27asthma10.0IL18R1, SELPLG, MMP12
28hereditary spherocytosis10.0TFRC, ANK1
29ischemia10.0SELPLG, MAP2, CXCL2
30rhyns syndrome10.0CYBB, FSCN2, RGR
31malaria10.0MPP1, IL18R1, TFRC
32peritonitis10.0IL18R1, CXCL2, SELPLG
33cadasil10.0SELPLG, IL18R1, MAP2, MMP12
34multiple sclerosis10.0TFRC, IL18R1, MAP2, SELPLG, MMP12
35siderosis10.0TFRC, GPT
36atherosclerosis10.0CYBB, IL18R1, SELPLG, MMP12
37hepatitis10.0TFRC, GPT
38leukemia10.0CXCL2, IL18R1, TFRC, FUT7, SELPLG, CYBB
39viral infectious disease10.0GPT, TFRC, IL18R1, CXCL2
40ipex syndrome10.0GPT, IL18R1, MAP2, MPP1, TFRC, TNFRSF9
41burkitt's lymphoma10.0MAP2, TFRC, MPP1, FUT7, TNFRSF9
42melanoma10.0MPP1, MAP2, CXCL2, TFRC, IL18R1, MMP12
43hemophagocytic lymphohistiocytosis9.9
44adult respiratory distress syndrome9.9
45tick paralysis9.9
46sennetsu fever9.9
47chagas disease9.9
48pancytopenia9.9
49thrombotic thrombocytopenic purpura9.9
50appendicitis9.9

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Clinical Features for Ehrlichiosis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 4)
  • headache
  • fatigue
  • rash
  • muscle aches

Drugs & Therapeutics for Ehrlichiosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ehrlichiosis

Drug clinical trials:

Search ClinicalTrials for Ehrlichiosis

Search NIH Clinical Center for Ehrlichiosis

Search CenterWatch for Ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

Sources:
14FMA
See all sources

FMA organs/tissues related to Ehrlichiosis:

14
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ehrlichiosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.0FUT7, SELPLG, MMP12, IL18R1, CYBB, ANK1

Publications for Ehrlichiosis

Sources:
51PubMed
See all sources

Articles related to Ehrlichiosis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Serum cardiac troponin I concentrations in naturally occurring myelosuppressive and non-myelosuppressive canine monocytic ehrlichiosis. (22633176)
2012
2
Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia. (22267937)
2011
3
Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. (21108506)
2010
4
Evaluation of a serum-based PCR assay for the diagnosis of canine monocytic ehrlichiosis. (19419823)
2009
5
Acute infection with human monocytic ehrlichiosis: the tip of the iceberg? (18364633)
2008
6
Detection of Ehrlichia canis by PCR in different tissues obtained during necropsy from dogs surveyed for naturally occurring canine monocytic ehrlichiosis. (17368942)
2008
7
Sero-prevalence and risk indicators for canine ehrlichiosis in three rural areas of Brazil. (17204439)
2007
8
More about human monocytotropic ehrlichiosis in Brazil: serological evidence of nine new cases. (16767308)
2006
9
Characteristic peripheral blood findings in human ehrlichiosis. (14976527)
2004
10
Polymerase chain reaction in detection of human granulocytic ehrlichiosis (HGE) agent DNA in Ixodes ricinus ticks. (15232900)
2003
11
Portal vein and aortic thromboses in a Siberian husky with ehrlichiosis and hypothyroidism. (14510331)
2003
12
Ehrlichia chaffeensis infections among HIV-infected patients in a human monocytic ehrlichiosis-endemic area. (14519250)
2003
13
Comparison of PCR assays for detection of the agent of human granulocytic ehrlichiosis, Anaplasma phagocytophilum. (12574272)
2003
14
Ehrlichiosis in Ixodes ricinus and wild mammals. (12141732)
2002
15
Outcomes of treated human granulocytic ehrlichiosis cases. (11971774)
2002
16
The prevalence of Borrelia burgdorfieri (Spirochaetales: spirochaetaceae) and the agent of human granulocytic ehrlichiosis (Rickettsiaceae: Ehrlichieae) in Ixodes scapularis (Acari:Ixodidae) collected during 1998 and 1999 from Minnesota. (11931260)
2002
17
Novel potential reservoirs for Borrelia sp. and the agent of human granulocytic ehrlichiosis in Colorado. (12038153)
2002
18
Molecular typing of the etiologic agent of human granulocytic ehrlichiosis. (11526190)
2001
19
Equine monocytic Ehrlichiosis (Potomac horse fever) in horses in Uruguay and southern Brazil. (11580069)
2001
20
Human granulocytic ehrlichiosis agent inhibits superoxide anion generation by human neutrophils. (11083784)
2000
21
Human monocytic ehrlichiosis: a potentially severe disease in children. (10922287)
2000
22
Improved sensitivity of PCR for diagnosis of human granulocytic ehrlichiosis using epank1 genes of Ehrlichia phagocytophila-group ehrlichiae. (10618115)
2000
23
Minimal change nephrotic syndrome: a possible complication of ehrlichiosis. (10460510)
1999
24
Quantification of the human granulocytic ehrlichiosis agent based on analysis of rRNA isolated from control and infected HL-60 cells. (10448059)
1999
25
Changes in expression of the 44-kilodalton outer surface membrane antigen (p44 kD) for monitoring progression of infection and antimicrobial susceptibility of the human granulocytic ehrlichiosis (HGE) agent in HL-60 cells. (10198216)
1999
26
Human granulocytic ehrlichiosis in western Europe. (10206853)
1999
27
Recent advances in determining the pathogenesis of canine monocytic ehrlichiosis. (10449445)
1999
28
Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky Mountain spotted fever and ehrlichiosis. (9934930)
1999
29
Comparison of Ehrlichia chaffeensis recombinant proteins for serologic diagnosis of human monocytotropic ehrlichiosis. (10405403)
1999
30
Polymerase chain reaction detection efficiency of the human granulocytic ehrlichiosis agent (Rickettsiaceae: Ehrlichieae) in ticks (Acari: Ixodidae) is dependent on the DNA extraction method. (10593061)
1999
31
Immunoserologic evidence of Human Granulocytic Ehrlichiosis in Danish patients with Lyme neuroborreliosis. (9730306)
1998
32
Serologic evidence of a natural infection of white-tailed deer with the agent of human granulocytic ehrlichiosis in Wisconsin and Maryland. (9801331)
1998
33
Update: human ehrlichiosis--Maryland and Wisconsin, 1994. (9656961)
1998
34
Cytoplasmic, nuclear, and platelet autoantibodies in human granulocytic ehrlichiosis patients. (9650944)
1998
35
Seroprevalence of human granulocytic ehrlichiosis among permanent residents of northwestern Wisconsin. (9868666)
1998
36
Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains. (9527787)
1998
37
Canine ehrlichiosis in the Comunidad de Madrid in central Spain. (9668507)
1998
38
Perinatal transmission of human granulocytic ehrlichiosis. (9874610)
1998
39
Fever, leukopenia, and thrombocytopenia in a patient with acute Lyme borreliosis were due to human granulocytic ehrlichiosis. (9455582)
1998
40
The agent of Human Granulocytic Ehrlichiosis resides in an endosomal compartment. (9576758)
1998
41
Positive Lyme disease serology in patients with clinical and laboratory evidence of human granulocytic ehrlichiosis. (9024062)
1997
42
Antibodies to multiple tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in white-footed mice. (9249691)
1997
43
The human granulocytic ehrlichiosis (HGE) agent in Swedish ticks. (11864185)
1997
44
Human monocytic ehrlichiosis in children. (9200384)
1997
45
False-positive Lyme disease serology in human granulocytic ehrlichiosis. (8598802)
1996
46
Human ehrlichiosis. (8900357)
1996
47
Serological evidence of human granulocytic ehrlichiosis in Norway. (8950565)
1996
48
From the Centers for Disease Control and Prevention. Human ehrlichiosis--Maryland, 1994. (8849737)
1996
49
Ehrlichiosis in Belgium. (7475691)
1995
50
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992

Genetic Variations for Ehrlichiosis

Expression for genes affiliated with Ehrlichiosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

Compounds for genes affiliated with Ehrlichiosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Ehrlichiosis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1succinylacetone4510.4CYBB, TFRC
2neopterin4510.3GPT, IL18R1, TFRC
3polylactosamine4510.2SELPLG, FUT7
4polysaccharide4510.1FUT7, SELPLG, IL18R1, TFRC
5n acetylcysteine4510.1TFRC, CXCL2, MMP12, GPT
6acridine4510.1TFRC, MPP2
7sialic acid4510.0FUT7, SELPLG, TFRC
8ethanol45 50 11 2413.0MAP2, CXCL2, IL18R1, GPT
9fibrinogen4510.0CXCL2, MMP12, GPT, SELPLG
10oxygen45 2410.9CYBB, CXCL2, IL18R1, MMP12, SELPLG
11vegf459.8TFRC, MAP2, CYBB, CXCL2, IL18R1, MMP12
12mannose 6-phosphate45 2410.7MPP2, MPP1, TFRC
13serine459.7MAP2, CYBB, CXCL2, IL18R1, MMP12, SELPLG
14dexamethasone45 50 29 1112.6TNFRSF9, TFRC, CYBB, CXCL2, IL18R1, MMP12
15glucose459.6MPP1, MPP2, MAP2, CYBB, IL18R1, GPT
16lipid459.6MPP1, ANK1, CXCL2, IL18R1, MMP12, GPT
17glycogen45 2410.4MPP2, MAP2, CXCL2, GPT
18tyrosine458.9SELPLG, NSUN5, TNFRSF9, TFRC, MPP1, ANK1

GO Terms for genes affiliated with Ehrlichiosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stereociliumGO:03242010.1FSCN2, MPP1
2cortical cytoskeletonGO:0308639.8ANK1, MPP1
3integral to plasma membraneGO:0058879.1SELPLG, TNFRSF9, TFRC, MPP1, MPP2, CYBB

Molecular functions related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanylate kinase activityGO:00438510.0MPP2, MPP1

Products for genes affiliated with Ehrlichiosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ehrlichiosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet