MCID: EHR002
MIFTS: 41

Ehrlichiosis malady

Categories: Rare diseases, Infectious diseases, Blood diseases

Aliases & Classifications for Ehrlichiosis

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ehrlichiosis:

Name: Ehrlichiosis 11 48 54 50 39 13 68
Human Ehrlichiosis 11 48 2 68
 
He 48

Characteristics:

Orphanet epidemiological data:

54
ehrlichiosis:
Prevalence: 1-9/1000000 (United States); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:10242
ICD1030 A77.4, A77.40
ICD9CM32 082.4, 082.40
MeSH39 D016873
SNOMED-CT62 77361002
Orphanet54 ORPHA1902
MESH via Orphanet40 D016873
UMLS via Orphanet69 C0085399
ICD10 via Orphanet31 A48.8

Summaries for Ehrlichiosis

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Disease Ontology:11 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways are amb2 Integrin signaling and Iron metabolism in placenta. Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotypes are Mildly decreased CFP-tsO45G cell surface transport and cardiovascular system.

Wikipedia:71 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

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Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

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Symptoms:

 11 (show all 4)
  • headache
  • muscle aches
  • fatigue
  • rash

GenomeRNAi Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00360-A-17.3ACO1, ANK1, FAM161A, FSCN2, FUT7, HSPD1

MGI Mouse Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.8ANK1, CASP3, CYBB, FAM161A, FUT7, SELP
2MP:00053678.8ANK1, CASP3, CYBB, SELP, SELPLG
3MP:00053978.5ANK1, CASP3, CYBB, FAM161A, FUT7, SELP
4MP:00053878.5ANK1, CASP3, CYBB, FAM161A, FUT7, SELP
5MP:00036317.5ANK1, CASP3, CYBB, FAM161A, FSCN2, HSPD1

Drugs & Therapeutics for Ehrlichiosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ehrlichiosis


Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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MalaCards organs/tissues related to Ehrlichiosis:

36
Monocytes, Testes, T cells, Neutrophil, Bone marrow, Bone, Liver

FMA organs/tissues related to Ehrlichiosis:

17
Leukocyte

Publications for Ehrlichiosis

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Articles related to Ehrlichiosis:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Development of Structure-Based Vaccines for Ehrlichiosis. (27076151)
2016
2
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. (27575459)
2016
3
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. (27308282)
2016
4
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. (26854345)
2016
5
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. (27388158)
2016
6
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. (27758794)
2016
7
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. (27142117)
2016
8
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. (26837859)
2016
9
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. (26918212)
2016
10
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. (26621564)
2016
11
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. (27633921)
2016
12
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. (27876946)
2016
13
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. (27088220)
2016
14
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. (27097347)
2016
15
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. (26621561)
2016
16
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. (25888870)
2015
17
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. (26083691)
2015
18
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. (26616656)
2015
19
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. (27065635)
2015
20
Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. (25449215)
2015
21
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. (26018824)
2015
22
Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. (25649069)
2015
23
Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data. (25756797)
2015
24
First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania. (25867940)
2015
25
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. (26062723)
2015
26
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. (26414283)
2015
27
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). (25957922)
2015
28
The perils of country life: human monocytic ehrlichiosis. (25912197)
2015
29
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. (25737562)
2015
30
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). (25770893)
2015
31
1217: EXTRACORPOREAL MEMBRANE OXYGENATION FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO EHRLICHIOSIS. (26570878)
2015
32
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. (25565883)
2015
33
Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in Southern Europe. (25561342)
2015
34
Sinus Bradycardia: Can We Blame Ehrlichiosis? (25232718)
2014
35
An Animal Model of a Newly Emerging Human Ehrlichiosis. (24990203)
2014
36
Vector-borne pathogens in dogs from Costa Rica: First molecular description of Babesia vogeli and Hepatozoon canis infections with a high prevalence of monocytic ehrlichiosis and the manifestations of co-infection. (24315693)
2014
37
A novel Ehrlichia genotype strain distinguished by the TRP36 gene naturally infects cattle in Brazil and causes clinical manifestations associated with ehrlichiosis. (24915874)
2014
38
Intracytoplasmic granulocytic morulae counts on confirmed cases of ehrlichiosis/anaplasmosis in the Northeast. (24713739)
2014
39
Doxycycline desensitization for a suspected case of ehrlichiosis. (24565779)
2014
40
Serum canine pancreatic lipase immunoreactivity in experimentally induced and naturally occurring canine monocytic ehrlichiosis (Ehrlichia canis). (24530039)
2014
41
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. (25332563)
2014
42
Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis. (24491580)
2014
43
Clinical history and hematological findings among canines with monocytic ehrlichiosis. (24964665)
2014
44
Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis in a Child. (24691079)
2014
45
A case of human monocytic ehrlichiosis in Serbia. (24684037)
2014
46
Bayesian spatio-temporal analysis and geospatial risk factors of human monocytic ehrlichiosis. (24992684)
2014
47
Usefulness of a rapid immuno-migration test for the detection of canine monocytic ehrlichiosis in Africa. (24252768)
2014
48
Acute respiratory distress syndrome in human granulocytic ehrlichiosis. (25672061)
2014
49
Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis. (24144475)
2013
50
Study of ehrlichiosis in kennel dogs under treatment and prevention during seven months in Dakar (Senegal). (24018180)
2013

Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9SELP, SELPLG
29.9ACO1, TFRC

GO Terms for genes affiliated with Ehrlichiosis

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Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:000687910.5ACO1, TFRC
2response to lipopolysaccharideGO:00324969.8CASP3, HSPD1, SELP
3response to hypoxiaGO:00016669.8CASP3, HSPD1, TFRC
4response to organic cyclic compoundGO:00140709.8CASP3, HSPD1, SELP
5visual perceptionGO:00076018.7FAM161A, FSCN2, RGR

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.6HSPD1, SELP

Sources for Ehrlichiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet