HE
MCID: EHR002
MIFTS: 53

Ehrlichiosis (HE) malady

Rare diseases, Infectious diseases, Blood diseases categories

Summaries for Ehrlichiosis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including rash, fatigue and muscle aches. An important gene associated with Ehrlichiosis is MAP2 (microtubule-associated protein 2), and among its related pathways are Phagosome and HIF-1 signaling pathway. The compounds nocodazole and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotypes are nervous system and hematopoietic system.

Disease Ontology:9 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in ehrlichia chaffeensis or anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. the infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia:66 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Aliases & Classifications for Ehrlichiosis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 28ICD9CM, 36MeSH, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
ehrlichiosis:
Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

ehrlichiosis 9 44 11 46 50 63
human ehrlichiosis 9 44 63
he 44


External Ids:

Disease Ontology9 DOID:10242
ICD9CM28 082.40, 082.4
MeSH36 D016873
MESH via Orphanet37 D016873
SNOMED-CT59 77361002
ICD10 via Orphanet27 A48.8
SNOMED-CT via Orphanet60 77361002
UMLS via Orphanet64 C0085399

Related Diseases for Ehrlichiosis

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18GeneCards, 19GeneDecks
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Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1human monocytic ehrlichiosis31.1MMP12, RGR, MAP2
2human granulocytic anaplasmosis30.7RGR, SELPLG, MMP12
3leukemia29.8SELPLG, CYBB, TFRC
4lyme disease10.6
5babesiosis10.5
6rocky mountain spotted fever10.3
7spotted fever10.3
8encephalitis10.3
9tick-borne encephalitis10.3
10thrombocytopenia10.2
11tick infestation10.2
12hepatitis10.1
13celiac disease10.0MMP12, TFRC
14amyotrophic lateral sclerosis10.0TFRC, MAP2
15cork-handlers' disease10.0TFRC, MMP12
16pulmonary disease, chronic obstructive10.0SELPLG, MMP12
17vascular disease10.0SELPLG, MAP2
18brain cancer10.0MAP2, TFRC
19rhyns syndrome10.0RGR, CYBB
20lung small cell carcinoma10.0SELPLG, MAP2
21malignant glioma10.0MAP2, MMP12, TFRC
22immunodeficiency with hyper igm type 210.0TFRC, MAP2
23cerebrovascular disease10.0SELPLG, MMP12, MAP2
24melanoma10.0MMP12, TFRC, MAP2
25myeloid leukemia10.0TFRC, CYBB
26ipex syndrome10.0MAP2, CYBB, TFRC
27coronary artery disease9.9CYBB, SELPLG, MMP12
28atherosclerosis9.9MMP12, SELPLG, CYBB
29multiple sclerosis9.9MMP12, SELPLG, TFRC, MAP2
30thrombotic thrombocytopenic purpura9.9
31appendicitis9.9
32hemophagocytic lymphohistiocytosis9.9
33adult respiratory distress syndrome9.9
34tick paralysis9.9
35cat-scratch disease9.9
36sennetsu fever9.9
37q fever9.9
38cerebritis9.9
39chagas disease9.9
40pancytopenia9.9
41colorado tick fever9.9
42angioedema9.9
43arthritis9.9
44demyelinating polyneuropathy9.9
45diarrhea9.9
46histoplasmosis9.9
47hypothyroidism9.9
48lactic acidosis9.9
49leishmaniasis9.9
50malaria9.9

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Symptoms for Ehrlichiosis

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9Disease Ontology
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Symptoms:

9
  • rash
  • fatigue
  • muscle aches
  • headache

Drugs & Therapeutics for Ehrlichiosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Ehrlichiosis

Search CenterWatch for Ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Ehrlichiosis:

34
Monocytes, Testes, T cells, Bone marrow, Bone, Lung, Pancreas, B cells, Myeloid, Liver, Lymph node, Whole blood, Eye

FMA organs/tissues related to Ehrlichiosis:

15
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ehrlichiosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2MAP2, MMP12, CYBB, TFRC
2MP:00053977.9MMP12, SELPLG, CYBB, TFRC
3MP:00053877.7TFRC, CYBB, SELPLG, MMP12

Publications for Ehrlichiosis

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53PubMed
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Articles related to Ehrlichiosis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Prevalence of borreliosis, anaplasmosis, ehrlichiosis and Dirofilaria immitis in dogs and vectors in Voronezh Reserve (Russia). (24054985)
2013
2
Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis. (24144475)
2013
3
Social-ecological factors determine spatial variation in human incidence of tick-borne ehrlichiosis. (24280291)
2013
4
Serum acute phase proteins as clinical phase indicators and outcome predictors in naturally occurring canine monocytic ehrlichiosis. (21564293)
2011
5
Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. (21108506)
2010
6
Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia. (19018569)
2009
7
The importance of early treatment with doxycycline in human ehrlichiosis. (18344803)
2008
8
Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis. (17562770)
2007
9
Two cases of human granulocytic ehrlichiosis in Sardinia, Italy confirmed by PCR. (17114774)
2006
10
Surveys on seroprevalence of canine monocytic ehrlichiosis among dogs living in the Ivory Coast and Gabon and evaluation of a quick commercial test kit dot-ELISA. (17114755)
2006
11
Bone marrow mastocytosis in dogs with myelosuppressive monocytic ehrlichiosis (Ehrlichia canis): a retrospective study. (16967415)
2006
12
Evaluation of neutrophil oxidative metabolism in canine monocytic ehrlichiosis. (16134067)
2005
13
Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. (14742542)
2004
14
Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. (14734762)
2004
15
Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. (12817434)
2003
16
Comparison of patients fulfilling criteria for confirmed and probable human granulocytic ehrlichiosis. (12860648)
2003
17
Evaluation of cytology in the diagnosis of acute canine monocytic ehrlichiosis (Ehrlichia canis): a comparison between five methods. (12458168)
2003
18
Ehrlichiosis in anemic, thrombocytopenic, or tick-infested dogs from a hospital population in South Brazil. (14637030)
2003
19
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
20
Ehrlichiosis in Ixodes ricinus and wild mammals. (12141732)
2002
21
Granulocytic ehrlichiosis in Swedish dogs and horses. (12141731)
2002
22
Serologic evidence of ehrlichiosis among humans and wild animals in The Netherlands. (11915850)
2002
23
Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction. (11716122)
2001
24
Molecular typing of the etiologic agent of human granulocytic ehrlichiosis. (11526190)
2001
25
Serologic evidence of human monocytic and granulocytic ehrlichiosis in Israel. (10827125)
2000
26
Human granulocytic ehrlichiosis agent infection in a pony vaccinated with a Borrelia burgdorferi recombinant OspA vaccine and challenged by exposure to naturally infected ticks. (10618280)
2000
27
Survival of the human granulocytic ehrlichiosis agent under refrigeration conditions. (10835014)
2000
28
A simian model of human granulocytic ehrlichiosis. (10403332)
1999
29
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. (10225882)
1999
30
Human granulocytic ehrlichiosis in Northern California: two case descriptions with genetic analysis of the Ehrlichiae. (10476747)
1999
31
Recurrent human granulocytic ehrlichiosis and Lyme disease. (10383360)
1999
32
Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry. (9725558)
1998
33
Immunoserologic evidence of Human Granulocytic Ehrlichiosis in Danish patients with Lyme neuroborreliosis. (9730306)
1998
34
Serologic evidence of a natural infection of white-tailed deer with the agent of human granulocytic ehrlichiosis in Wisconsin and Maryland. (9801331)
1998
35
Granulocytic ehrlichiosis: an emerging or rediscovered tick-borne disease? (9879965)
1998
36
Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: evaluation of a 6-week course. (9650986)
1998
37
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. (9455892)
1998
38
Detection of the agent of human granulocytic ehrlichiosis (HGE) in UK ticks using polymerase chain reaction. (10030718)
1998
39
Serological evidence of human granulocytic ehrlichiosis in Switzerland. (9665305)
1998
40
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
41
Characterization of an immunoreactive protein from the agent of human granulocytic ehrlichiosis. (9114402)
1997
42
Human ehrlichiosis--Maryland, 1994. (8926996)
1996
43
A human case of monocytic ehrlichiosis with adult respiratory distress syndrome in northern California. (8764635)
1996
44
Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. (8748270)
1996
45
Human ehrlichiosis in the United States. (8714253)
1996
46
Apoptosis of gamma/delta T cells in human ehrlichiosis. (8623774)
1996
47
Human ehrlichiosis. (7591456)
1995
48
Ehrlichiosis in Belgium. (7475691)
1995
49
Human ehrlichiosis in a liver transplant recipient. (7482752)
1995
50
From the Centers for Disease Control and Prevention. Human granulocytic ehrlichiosis--New York, 1995. (7674488)
1995

Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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51PathCards, 31KEGG
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Pathways related to Ehrlichiosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CYBB, TFRC
29.1CYBB, TFRC

Compounds for genes affiliated with Ehrlichiosis

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 52PharmGKB
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Compounds related to Ehrlichiosis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1nocodazole46 1210.8MAP2, TFRC
2ionomycin469.5TFRC, MAP2
3sialic acid469.5TFRC, SELPLG
4carbohydrates469.4SELPLG, TFRC
5succinylacetone469.4CYBB, TFRC
6phorbol-12-myristate469.4TFRC, CYBB
7okadaic acid46 6210.2MAP2, CYBB
8phosphatidylinositol469.2TFRC, MMP12, MAP2
9vitamin a46 25 1211.2RGR, TFRC
10dmso469.0TFRC, CYBB, MAP2
11h2o2469.0MAP2, CYBB, TFRC
12phosphatidylserine46 30 1210.9SELPLG, CYBB
13nitric oxide46 25 1210.9MAP2, MMP12, CYBB
14retinoic acid46 259.8MAP2, CYBB, TFRC
15vegf468.5TFRC, CYBB, MMP12, MAP2
16oxygen46 259.4MAP2, MMP12, SELPLG, CYBB
17dexamethasone46 52 30 1211.3MMP12, SELPLG, CYBB, TFRC
18serine467.9MAP2, MMP12, SELPLG, CYBB, TFRC
19tyrosine467.9TFRC, CYBB, SELPLG, MMP12, MAP2

GO Terms for genes affiliated with Ehrlichiosis

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17Gene Ontology
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Cellular components related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.1RGR, SELPLG, CYBB, TFRC

Molecular functions related to Ehrlichiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.6RGR, MAP2, SELPLG, CYBB, TFRC

Products for genes affiliated with Ehrlichiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ehrlichiosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet