MCID: EHR002
MIFTS: 41

Ehrlichiosis malady

Categories: Rare diseases, Infectious diseases, Blood diseases

Aliases & Classifications for Ehrlichiosis

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 38MeSH, 39MESH via Orphanet, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ehrlichiosis:

Name: Ehrlichiosis 11 47 53 49 38 13 67
Human Ehrlichiosis 11 47 2 67
 
He 47

Characteristics:

Orphanet epidemiological data:

53
ehrlichiosis:
Prevalence: 1-9/1000000 (United States); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:10242
ICD1029 A77.4, A77.40
ICD9CM31 082.4, 082.40
MeSH38 D016873
SNOMED-CT61 77361002
Orphanet53 ORPHA1902
MESH via Orphanet39 D016873
UMLS via Orphanet68 C0085399
ICD10 via Orphanet30 A48.8

Summaries for Ehrlichiosis

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Disease Ontology:11 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary: Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways are amb2 Integrin signaling and Iron metabolism in placenta. Affiliated tissues include leukocyte, monocytes and testes, and related mouse phenotypes are cardiovascular system and renal/urinary system.

Wikipedia:70 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

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Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to ehrlichiosis

Symptoms for Ehrlichiosis

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Symptoms:

 11 (show all 4)
  • headache
  • muscle aches
  • fatigue
  • rash

Drugs & Therapeutics for Ehrlichiosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ehrlichiosis


Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

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Anatomical Context for Ehrlichiosis

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MalaCards organs/tissues related to Ehrlichiosis:

35
Monocytes, Testes, T cells, Neutrophil, Bone marrow, Bone, Liver

FMA organs/tissues related to Ehrlichiosis:

17
Leukocyte

Animal Models for Ehrlichiosis or affiliated genes

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MGI Mouse Phenotypes related to Ehrlichiosis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.8ANK1, CASP3, CYBB, FAM161A, FUT7, SELP
2MP:00053678.8ANK1, CASP3, CYBB, SELP, SELPLG
3MP:00053978.5ANK1, CASP3, CYBB, FAM161A, FUT7, SELP
4MP:00053878.5ANK1, CASP3, CYBB, FAM161A, FUT7, SELP
5MP:00036317.5ANK1, CASP3, CYBB, FAM161A, FSCN2, HSPD1

Publications for Ehrlichiosis

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Articles related to Ehrlichiosis:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. (25888870)
2015
2
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. (26083691)
2015
3
Sinus Bradycardia: Can We Blame Ehrlichiosis? (25232718)
2014
4
An Animal Model of a Newly Emerging Human Ehrlichiosis. (24990203)
2014
5
Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis. (24144475)
2013
6
Serum acute phase proteins as clinical phase indicators and outcome predictors in naturally occurring canine monocytic ehrlichiosis. (21564293)
2011
7
Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. (21108506)
2010
8
Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia. (19018569)
2009
9
Clinical relevance of annual screening using a commercial enzyme-linked immunosorbent assay (SNAP 3Dx) for canine ehrlichiosis. (19411647)
2009
10
Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis. (19805532)
2009
11
The importance of early treatment with doxycycline in human ehrlichiosis. (18344803)
2008
12
Sequence and phylogenetic analysis of the 16S rRNA gene of Ehrlichia canis strains in dogs with clinical monocytic ehrlichiosis. (17624694)
2007
13
Two cases of human granulocytic ehrlichiosis in Sardinia, Italy confirmed by PCR. (17114774)
2006
14
Surveys on seroprevalence of canine monocytic ehrlichiosis among dogs living in the Ivory Coast and Gabon and evaluation of a quick commercial test kit dot-ELISA. (17114755)
2006
15
Validation of chemoprevention of canine monocytic ehrlichiosis with doxycycline. (15863288)
2005
16
Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. (14742542)
2004
17
Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. (12817434)
2003
18
Ehrlichiosis in anemic, thrombocytopenic, or tick-infested dogs from a hospital population in South Brazil. (14637030)
2003
19
Polymerase chain reaction in detection of human granulocytic ehrlichiosis (HGE) agent DNA in Ixodes ricinus ticks. (15232900)
2003
20
Ehrlichiosis in Ixodes ricinus and wild mammals. (12141732)
2002
21
Granulocytic ehrlichiosis in Swedish dogs and horses. (12141731)
2002
22
PCR detection of Borrelia burgdorferi sensu lato, tick-borne encephalitis virus, and the human granulocytic ehrlichiosis agent in Ixodes persulcatus ticks from Western Siberia, Russia. (12354885)
2002
23
Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction. (11716122)
2001
24
Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. (11560261)
2001
25
Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. (11247709)
2001
26
Ehrlichiosis associated vasculitis. (10886489)
2000
27
Human granulocytic ehrlichiosis in Northern California: two case descriptions with genetic analysis of the Ehrlichiae. (10476747)
1999
28
Infection of laboratory mice with the human granulocytic ehrlichiosis agent does not induce antibodies to diagnostically significant Borrelia burgdorferi antigens. (10325386)
1999
29
Epidemiological aspects of human granulocytic Ehrlichiosis in southern Germany. (10666819)
1999
30
Fine structural characterisation of a Rickettsia-like organism in human platelets from patients with symptoms of ehrlichiosis. (10535642)
1999
31
Ehrlichiosis with severe pulmonary manifestations despite early treatment. (10094281)
1999
32
Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry. (9725558)
1998
33
Immunoserologic evidence of Human Granulocytic Ehrlichiosis in Danish patients with Lyme neuroborreliosis. (9730306)
1998
34
Serologic evidence of a natural infection of white-tailed deer with the agent of human granulocytic ehrlichiosis in Wisconsin and Maryland. (9801331)
1998
35
Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: evaluation of a 6-week course. (9650986)
1998
36
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. (9455892)
1998
37
Detection of the agent of human granulocytic ehrlichiosis (HGE) in UK ticks using polymerase chain reaction. (10030718)
1998
38
Update: human ehrlichiosis--Maryland and Wisconsin, 1994. (9656961)
1998
39
Saddleback fever due to human granulocytic ehrlichiosis. (9500331)
1998
40
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
41
Positive Lyme disease serology in patients with clinical and laboratory evidence of human granulocytic ehrlichiosis. (9024062)
1997
42
Human ehrlichiosis--Maryland, 1994. (8926996)
1996
43
Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. (8748270)
1996
44
Human ehrlichiosis in the United States. (8714253)
1996
45
False-positive Lyme disease serology in human granulocytic ehrlichiosis. (8598802)
1996
46
The interface between research and the diagnosis of an emerging tick-borne disease, human ehrlichiosis due to Ehrlichia chaffeensis. (8546547)
1996
47
Central nervous system manifestations of human ehrlichiosis. (8842270)
1996
48
Post-therapy antibody titers in dogs with ehrlichiosis: follow-up study on 68 patients treated primarily with tetracycline and/or doxycycline. (8819054)
1996
49
Ehrlichiosis in Belgium. (7475691)
1995
50
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992

Variations for Ehrlichiosis

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Expression for genes affiliated with Ehrlichiosis

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Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for genes affiliated with Ehrlichiosis

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Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9SELP, SELPLG
29.9ACO1, TFRC

GO Terms for genes affiliated with Ehrlichiosis

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Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:000687910.2ACO1, TFRC
2response to organic cyclic compoundGO:00140709.4CASP3, HSPD1, SELP
3response to lipopolysaccharideGO:00324969.4CASP3, HSPD1, SELP
4response to hypoxiaGO:00016669.2CASP3, HSPD1, TFRC
5visual perceptionGO:00076018.7FAM161A, FSCN2, RGR

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.6HSPD1, SELP

Sources for Ehrlichiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet