MCID: ESN011
MIFTS: 38

Eisenmenger Syndrome malady

Rare diseases, Respiratory diseases categories

Aliases & Classifications for Eisenmenger Syndrome

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Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Eisenmenger Syndrome:

Name: Eisenmenger Syndrome 45 47 51
 
Eisenmenger Complex 65


Classifications:



Characteristics (Orphanet epidemiological data):

51
eisenmenger syndrome:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Belgium),1-9/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood; Age of death: adult


External Ids:

Orphanet51 97214
ICD10 via Orphanet28 I27.2

Summaries for Eisenmenger Syndrome

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NIH Rare Diseases:45 Eisenmenger syndrome is a rare progressive heart condition caused by a structural error in the heart, typically a "hole in the heart" (ventricular septal defect) present at birth (congenital heart defect). this causes abnormal blood flow in the heart, resulting in high pressure within the pulmonary artery, the main blood vessel that connects the heart to the lungs (pulmonary hypertension). last updated: 10/21/2010

MalaCards based summary: Eisenmenger Syndrome, also known as eisenmenger complex, is related to ventricular septal defect and myocardial infarction. An important gene associated with Eisenmenger Syndrome is THBD (Thrombomodulin), and among its related pathways are NTHi-Induced Signaling and Complement and coagulation cascades. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are normal and skeleton.

Related Diseases for Eisenmenger Syndrome

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Diseases related to Eisenmenger Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1ventricular septal defect30.9PLAT, VWF
2myocardial infarction29.8EDN1, PLAT, THBD, VWF
3hypertension, essential29.4BMPR2, EDN1, PLAT, TGFB1, THBD, VWF
4pulmonary hypertension10.7
5congenital heart disease10.7
6adult syndrome10.5
7patent ductus arteriosus10.4
8coronary heart disease 310.4
9coronary heart disease 510.3
10child syndrome10.3
11kid syndrome10.3
12endotheliitis10.3
13coronary heart disease 210.3
14coronary heart disease 610.3
15vascular malformation10.3
16uniparental disomy of 610.2THBD, VWF
17crohn's disease10.2EDN1, VWF
18parotitis10.2EDN1, VWF
19pulmonary valve agenesis - fallot's tetralogy - absence of ductus arteriosus10.2THBD, VWF
20extrahepatic bile duct papillary adenoma10.2EDN1, VWF
21sternum cancer10.2THBD, VWF
22iga nephropathy 110.2
23pulmonary hypertension, primary, 310.2
24tetralogy of fallot10.2
25pulmonary hypertension, primary, 210.2
26poland syndrome10.2
27vascular disease10.2
28withdrawal disorder10.2
29heritable pulmonary arterial hypertension10.2
30coronary arteries congenital malformation10.2
31pediatric hypertension10.2
32dawson disease10.2
33truncus arteriosus10.2
34idiopathic and/or familial pulmonary arterial hypertension10.2
35nevada syndrome10.2
36logopenic progressive aphasia10.2TGFBR1, TGFBR2
37loeys-dietz syndrome type 2a10.2TGFBR1, TGFBR2
38skin fragility-woolly hair-palmoplantar keratoderma syndrome10.2TGFBR1, TGFBR2
39familial treacher collins syndrome10.2TGFBR1, TGFBR2
40congenital epstein-barr virus infection10.2BMPR2, EDN1
41thumb absent short stature immune deficiency10.2THBD, VWF
42chronic purulent otitis media10.2BMPR2, EDN1
43premature chromatid separation trait10.2TGFBR1, TGFBR2
44umod-associated kidney disease10.1TGFBR1, TGFBR2
45chronic fatigue syndrome10.1THBD, VWF
46ovarian mucinous malignant adenofibroma10.1TGFBR1, TGFBR2
47merlob grunebaum reisner syndrome10.1PLAT, THBD
48norum disease10.1PLAT, THBD
49choroid necrotic melanoma10.1TGFBR1, TGFBR2
50gestational diabetes10.1EDN1, THBD, VWF

Graphical network of the top 20 diseases related to Eisenmenger Syndrome:



Diseases related to eisenmenger syndrome

Symptoms for Eisenmenger Syndrome

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Drugs & Therapeutics for Eisenmenger Syndrome

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Drugs for Eisenmenger Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bosentanapproved, investigationalPhase 4, Phase 399147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
2
Iloprostapproved, investigationalPhase 47378919-13-86443959
Synonyms:
(16R,S)-Methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I(sub 2)
(5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
(5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric acid
(E)-5-(3aS,4R,5R,6aS)-5-Hydroxy-4((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-inyl)perhydropentalen-2-yliden)valeriansaeure
73873-87-7
78919-13-8
AC1NSK5T
AC1O5JIJ
AC1O5JP3
AC1Q1J28
ACT-213105
C22H32O4
CHEMBL138694
CHEMBL236025
CHEMBL494
CID10937300
CID11639089
CID5311181
CID6435293
CID6435378
CID9885245
 
CID9975807
Ciloprost
D02721
E-1030
Endoprost
HMS2090A19
ILOPROST
Ilomedin
Ilomedine
Iloprost
Iloprost (INN)
Iloprost [BAN:INN]
Iloprostum
Iloprostum [Latin]
L000996
LS-101845
NCGC00181784-01
PDSP2_001536
SH-401
UNII-JED5K35YGL
Ventavis
Ventavis (TN)
ZK 36374
ZK-36374
ZK-363775
[3H]-Iloprost
3
Sildenafilapproved, investigationalPhase 3, Phase 1, Phase 2296139755-83-25212
Synonyms:
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-D)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
139755-83-2
171599-83-0 (citrate)
1udt
1xos
2h42
5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (Sildenafil or Viagra)
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one(Sildenafil)
5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
5-{2-(ethyloxy)-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
AC-938
AC1L1JUI
Ambap139755-83-2
Aphrodil
Aphrodil (TN)
BAS 04213629
BIDD:GT0352
BRD-K79759585-001-02-1
BSPBio_003424
C07259
C22H30N6O4S
CHEBI:9139
CHEMBL192
CID5212
Caverta
D08514
DB00203
DivK1c_006894
HMS1684K08
HMS1922B19
HMS2089M12
HMS2093O17
HSDB 7305
 
I06-0023
Jsp002373
KBio1_001838
KBio2_002035
KBio2_004603
KBio2_007171
KBio3_002927
KBioGR_001052
KBioSS_002035
LS-111655
MLS001240224
MLS001304737
MolPort-001-995-394
MolPort-002-885-861
NCGC00095099-01
NCGC00095099-02
NCGC00159496-02
Revatio
SMR000752512
SPBio_001775
SPECTRUM1504099
Sildenafil
Sildenafil (INN)
Sildenafil Citrate
Sildenafil Viagra
Sildenafil [INN:BAN]
Sildenafil citrate
SpecPlus_000798
Spectrum2_001648
Spectrum3_001892
Spectrum4_000586
Spectrum5_001508
Spectrum_001555
UK-92,480-10
UK-92480
UNII-3M7OB98Y7H
VIA
Viagra
sildenafil
4Phosphodiesterase 5 InhibitorsPhase 3, Phase 2, Phase 1518
5
MilrinoneapprovedPhase 1, Phase 22678415-72-24197
Synonyms:
-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4&prime
1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
111GE027
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
78415-72-2
AB00514027
AC-4730
AC1L1HMP
AC1Q2EBX
BIDD:GT0197
BPBio1_001156
BRN 3546821
BSPBio_001050
C07224
C12H9N3O
CAS-78415-72-2
CCRIS 3795
CHEBI:50693
CHEMBL189
CID4197
CPD000058475
Corotrop
Corotrope
D00417
DB00235
EINECS 278-903-6
EN002063
EU-0100737
HMS1571E12
HMS2051L10
HMS2090J14
I06-0259
LS-44610
Lopac-M-4659
Lopac0_000737
 
M 4659
M1663
M4659_SIGMA
MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER
MLS000028818
MLS001424052
Milrila
Milrila (TN)
Milrinona
Milrinona [Spanish]
Milrinone
Milrinone (JAN/USAN/INN)
Milrinone Lactate
Milrinone [USAN:BAN:INN]
Milrinonum
Milrinonum [Latin]
NCGC00015675-01
NCGC00015675-02
NCGC00015675-04
NCGC00015675-07
NCGC00025189-01
NCGC00025189-02
NCGC00025189-03
NCGC00164390-01
PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER
Prestwick0_001065
Prestwick1_001065
Prestwick2_001065
Prestwick3_001065
Primacor
S2484_Selleck
SAM001246611
SBB055743
SMR000058475
SPBio_002965
Tocris-1504
UNII-JU9YAX04C7
WIN 47203-2
Win-47203
Win-47203-2
YM 018
ZINC09224016
milrinone
6
Tadalafilapproved, investigationalPhase 2137171596-29-5110635
Synonyms:
(6R,12AR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
171596-29-5
1xoz
6-BENZO[1,3]dioxol-5-yl-2-methyl-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
AC1L380B
ADCIRCA
Acdirca
Adcirca
C429886
CHEBI:41488
CHEMBL779
CID110635
CPD000466321
Cialis
Cialis (TN)
Cialis, GF 196960, IC 351, ICOS 351, Tadalafil
D02008
DB00820
FT-0080116
GF 196960
GF-196960
 
HMS2051N17
HSDB 7303
IC 351
IC-351
ICOS 351
Ic351
KS-1117
LS-186558
LS-187015
LS-187770
Lilly brand of tadalafil
MLS000759426
MLS001165782
MLS001195644
MLS001424132
MolPort-002-885-864
S1512_Selleck
SAM001246586
SMR000466321
Tadalafil
Tadalafil (JAN/USAN/INN)
Tadalafil [USAN]
Tadanafil
UNII-742SXX0ICT
ZINC03993855
7Phosphodiesterase 3 InhibitorsPhase 1, Phase 2111
8
Treprostinilapproved, investigational7181846-19-754786, 6918140
Synonyms:
((1R,2R,3aS,9aS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate
(1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl] oxy]acetic acid
({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
15 AU81
15AU81
2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
289480-64-4 (Sodium salt)
81846-19-7
AC1L1HPX
AC1OCF2J
CHEBI:50861
CID11246284
CID54786
CID6918140
CID9800580
D06213
DB00374
L001079
LRX 15
 
LS-177654
LS-187014
LS-187645
Orenitram
Remodulin
Remodulin (TN)
Treprostinil
Treprostinil (USAN/INN)
Treprostinil [USAN:INN]
Treprostinil sodium
Treprostinilo
Treprostinilum
Tyvaso
U 62840
U-62,840
UNII-RUM6K67ESG
UT-15
Uniprost
Viveta
[[(1R,2R,3aS,9aS)-2-Hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphtalen-5-yl]oxy]acetic acid
treprostinilo
treprostinilum
9
imatinibapproved567152459-95-5644241, 5291
Synonyms:
112GI019
152459-95-5
1iep
1xbb
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide methanesulfonate
4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
AC-524
AC1L1K0Z
AKOS000280662
BIDD:GT0047
BRD-K92723993-066-02-9
Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- (9CI)
CCRIS 9076
CGP 57148B
CGP57148
CGP57148B
CHEBI:45783
CHEMBL941
CID5291
Cgp 57148
D08066
DB00619
DB03261
EN002706
FT-0083542
Glamox
Glamox (TN)
 
Gleevec
Glivec
HMS2089D03
I01-1232
Imatinib
Imatinib (INN)
Imatinib Mesylate
Imatinib Methansulfonate
Imatinib [INN:BAN]
Imatinib free base
Imatinibum
Kinome_3724
LS-182208
LS-187106
MolPort-000-883-342
N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
NCGC00159456-02
NCGC00159456-03
NCGC00159456-04
NSC743414
STI
STI 571
STI-571
STI571
STK617705
UNII-BKJ8M8G5HI
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
imatinib
nchembio.117-comp23
nchembio.162-comp5
nchembio.282-comp6
nchembio.83-comp14
sti-571
10
Epoprostenolapproved3035121-78-95280427, 5282411
Synonyms:
(5E)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3R)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
(5Z)-5-[(4R,5R)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
(5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoic acid
(5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoic acid
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid
(5Z,13E,15S)-6,9a-epoxy-11a,15-dihydroxyprosta-5,13-dienoate
(5Z,13E,15S)-6,9a-epoxy-11a,15-dihydroxyprosta-5,13-dienoic acid
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid
(5Z,13e)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
(5Z,9a,11a,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oate
(5Z,9a,11a,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
(5Z,9alpha,11alpha,13E,15S)-11,15-dihydroxy-6,9-epoxyprosta-5,13-dien-1-oic acid
(5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oate
(5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
(5Z,9alpha,11alpha,13e,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
(Z)-(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S)-3-hydroxy-1-octenyl)-2H-cyclopenta(b)furan-delta(sup 2,delta)-valeric acid
136626-78-3
35121-78-9
5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
5-[5-hydroxy-4-(3-hydroxyoct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
6,9-alpha-Epoxy-11-alpha,15(S)-dihydroxyprosta-5(Z),13(E)-dien-1-oic acid
61849-14-7
63748-50-5
63859-31-4
AC1L18LX
AC1L3FZB
AC1NQX0K
AC1NR00P
AC1O51WG
AC1O5HI7
AR-1I7150
BIDD:GT0514
BRD-K64054020-001-02-7
BRN 1690090
BSPBio_001496
Bio2_000216
Bio2_000696
C01312
CHEBI:15552
CHEMBL1139
CHEMBL307845
CID114805
CID11969614
CID159
CID5280427
CID5282411
CID6434194
CID6450541
 
CID9864371
CID9975312
Caripul
D00106
DB01240
Epoprostanol
Epoprostenol
Epoprostenol (TN)
Epoprostenol (USAN/INN)
Epoprostenol [USAN:INN]
Epoprostenolum
Epoprostenolum [INN-Latin]
Flolan
HMS1791K18
HMS1989K18
IDI1_033966
KB-IV-24
KBio2_000216
KBio2_002784
KBio2_005352
KBio3_000431
KBio3_000432
KBioGR_000216
KBioSS_000216
LMFA03010087
LS-125828
NCGC00161285-01
NCGC00161285-02
NCGC00161285-03
PDSP1_001721
PDSP2_001704
PG-I2
PGI(sub 2)
PGI2
PGX
Prostacyclin
Prostacyclin I2
Prostacycline
Prostacyclins
Prostaglandin I
Prostaglandin I(2)
Prostaglandin I2
Prostaglandin X
Prostaglandin x
Prostaglandins X
SMP2_000227
TRY 200
Try-200
U 53,217
U-53217
UNII-DCR9Z582X0
Vasocyclin
epoprostenol
prostacyclin
prostaglandin I2
11
Allopurinolapproved125315-30-02094
Synonyms:
1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one
1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidine-4-one
184856-42-6
1H-Pyrazolo(3,4-D)pyrimidin-4-ol
22767-92-6
315-30-0
39464-14-7
4'-Hydroxypyrazolol(3,4-D)pyrimidine
4-HPP
4-Hydroxy-1H-pyrazolo(3,4-D)pyrimidine
4-Hydroxy-3,4-pyrazolopyrimidine
4-Hydroxypyrazolo(3,4-D)pyrimidine
4-Hydroxypyrazolopyrimidine
4-Hydroxypyrazolyl(3,4-D)pyrimidine
4H-Pyrazolo(3,4-D)pyrimidin-4-one
7HP
A 8003
A0907
A8003_SIGMA
AC-019
AC1L1CWL
AC1Q6FWV
AC1Q6GP7
AKOS000267490
AKOS000269759
AL-100
Adenock
Ailural
Ailurial
Allo-Puren
Allohexal
Allohexan
Alloprin
Allopur
Allopurin
Allopurinol
Allopurinol Sodium
Allopurinol(I)
Allopurinolum
Allopurinolum [INN-Latin]
Allorin
Allozym
Allpargin
Allural
Aloprim
Alopurinol
Alopurinol [INN-Spanish]
Aloral
Alositol
Aluline
Anoprolin
Anzief
Apo-Allopurinol
Apulonga
Apurin
Apurol
Atisuril
B. W. 56-158
BB_SC-5394
BIM-0061756.0001
BSPBio_001798
BW 56-158
BW 56158
BW-56-158
Bio-0799
Bleminol
Bloxanth
C5H4N4O
CCRIS 626
CHEBI:40279
CHEBI:495607
CHEMBL1467
CID2094
CPD-9024
CPD000059083
Caplenal
Capurate
Cellidrin
Cosuric
D000493
DB00437
Dabrosin
Dabroson
DivK1c_000685
Dura Al
EINECS 206-250-9
EN000932
EU-0100102
Embarin
Epidropal
Epuric
Foligan
Geapur
Gichtex
Gotax
HMS1920A15
HMS2091G15
HMS502C07
HPP
 
HSDB 3004
Hamarin
Hexanuret
I03-0052
IDI1_000685
Jenapurinol
Jsp005881
KBio1_000685
KBio2_000386
KBio2_002954
KBio2_005522
KBio3_001298
KBioGR_000550
KBioSS_000386
Ketanrift
Ketobun-A
LS-1180
Ledopur
Lopac-A-8003
Lopac0_000102
Lopurin
Lysuron
MLS000069453
MLS001148183
Milurit
Milurite
Miniplanor
MolPort-000-141-383
MolPort-000-870-337
MolPort-004-758-159
MolPort-004-758-166
MolPort-004-758-167
MolPort-004-758-643
Monarch
NCGC00015094-01
NCGC00015094-03
NCGC00015094-06
NCGC00091134-01
NCGC00091134-02
NCGC00091134-03
NCGC00094580-01
NCGC00094580-02
NCIOpen2_001825
NINDS_000685
NSC 101655
NSC 1390
NSC-1390
NSC101655
NSC1390
Nektrohan
Novopurol
Pan Quimica
Prestwick_511
Progout
Pureduct
Purinol
Quimica, Pan
Remid
Riball
Rimapurinol
Roucol
S1630_Selleck
SAM002554884
SMR000059083
SPBio_000056
SPECTRUM1500108
STK378584
STK711106
Sigapurol
Spectrum2_000098
Spectrum3_000289
Spectrum4_000135
Spectrum5_000768
Spectrum_000026
Suspendol
Takanarumin
Tipuric
UNII-63CZ7GJN5I
Urbol
Uribenz
Uricemil
Uridocid
Uriprim
Uripurinol
Uritas
Urobenyl
Urolit
Urosin
Urtias
Urtias 100
Xanthomax
Xanturat
Xanturic
Zygout
Zyloprim
Zyloprim (tn)
Zyloric
allopurinol
nchembio.92-comp3
nchembio732-comp4
12
Ironapproved9577439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
13Tezosentan61

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger PhysiologyCompletedNCT00317486Phase 4
2Bosentan in Treatment of Pulmonary Arterial HypertensionCompletedNCT00266162Phase 4
3BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger PhysiologyCompletedNCT00367770Phase 4
4Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart DiseaseActive, not recruitingNCT01383083Phase 4
5Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers SyndromeCompletedNCT00303004Phase 3
6Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger SyndromeRecruitingNCT01743001Phase 3
7Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger SyndromeRecruitingNCT01739400Phase 3
8Therapy of Pulmonary Arterial Hypertension (PAH) - Treatment With Sildenafil in Eisenmenger PatientsTerminatedNCT00586794Phase 3
9Phosphodiesterase-5 Inhibitor in Eisenmenger SyndromeCompletedNCT01200732Phase 2
10Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary HypertensionCompletedNCT02595541Phase 1, Phase 2
11Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart DefectsRecruitingNCT01397110Phase 2
12The Effects of Inhaled Iloprost on Congenital Heart Disease With Eisenmenger SyndromeCompletedNCT01283958
13Effects Oxygen Supplementation Determined Better Exercise Capacity in Eisenmenger SyndromeCompletedNCT02661802
14Sleep-disordered Breathing in Eisenmenger SyndromeCompletedNCT02614417
15Eisenmenger's Syndrome in Adults With CHDCompletedNCT00266903
16Eisenmenger Quality Enhancement Research InitiativeRecruitingNCT01623492
17Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline MalateRecruitingNCT01683981Phase 0
18Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart ValvesRecruitingNCT02119442
19COMPERA / COMPERA-KIDSRecruitingNCT01347216
20Eisenmenger Syndrome in the Nordic CountriesActive, not recruitingNCT01976533
21Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart DiseaseTerminatedNCT01319045

Search NIH Clinical Center for Eisenmenger Syndrome

Genetic Tests for Eisenmenger Syndrome

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Anatomical Context for Eisenmenger Syndrome

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MalaCards organs/tissues related to Eisenmenger Syndrome:

33
Heart, Lung, Brain, Endothelial, Testes

Animal Models for Eisenmenger Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Eisenmenger Syndrome:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5BMPR2, EDN1, TGFBR1, TGFBR2, THBD, VIP
2MP:00053908.0BMPR2, EDN1, PLAT, TGFBR1, TGFBR2, TGFBR3
3MP:00053818.0EDN1, PLAT, TGFB1, TGFBR2, THBD, VWF
4MP:00053807.9BMPR2, EDN1, TGFB1, TGFBR1, TGFBR2, THBD
5MP:00053887.1BMPR2, PLAT, TGFB1, TGFBR1, TGFBR2, THBD
6MP:00053697.0BMPR2, EDN1, PLAT, TGFB1, TGFBR1, TGFBR2
7MP:00053846.8BMPR2, PLAT, TGFB1, TGFBR1, TGFBR2, TGFBR3
8MP:00036316.6BMPR2, EDN1, PLAT, TGFB1, TGFBR1, TGFBR2
9MP:00053976.5BMPR2, PLAT, TGFB1, TGFBR1, TGFBR2, TGFBR3
10MP:00053766.2BMPR2, EDN1, PLAT, TGFB1, TGFBR1, TGFBR2
11MP:00053856.0BMPR2, EDN1, PLAT, TGFB1, TGFBR1, TGFBR2
12MP:00107686.0BMPR2, EDN1, PLAT, TGFB1, TGFBR1, TGFBR2
13MP:00053875.9BMPR2, PLAT, TGFB1, TGFBR1, TGFBR2, TGFBR3

Publications for Eisenmenger Syndrome

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Articles related to Eisenmenger Syndrome:

(show top 50)    (show all 226)
idTitleAuthorsYear
1
Clinical and Prognostic Value of Depressive Symptoms and N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Eisenmenger Syndrome. (26355727)
2015
2
Pulmonary arterial wall thickness in Eisenmenger Syndrome: Prospective, cross-sectional, controlled clinical trial. (26110269)
2015
3
The exceptional and far-flung manifestations of heart failure in Eisenmenger syndrome. (24275297)
2014
4
Effect of bosentan therapy on ventricular and atrial function in adults with Eisenmenger syndrome. A prospective, multicenter study using conventional and Speckle tracking echocardiography. (24682249)
2014
5
Survival in Eisenmenger syndrome: a paradigm shift in outcomes research for adult congenital heart disease? (25099648)
2014
6
Inflammatory markers are elevated in Eisenmenger syndrome. (23666048)
2013
7
Impact of sildenafil on survival of patients with Eisenmenger syndrome. (23553708)
2013
8
Clubbing, cyanosis and a new diagnosis of atrial septal defect in a parturient: a straightforward diagnosis of Eisenmenger syndrome? (23329721)
2013
9
Red blood cell distribution width predicts survival in patients with Eisenmenger syndrome. (24317786)
2013
10
Patent ductus arteriosus with Eisenmenger syndrome. (23583537)
2013
11
Paracardiac mass on chest X-ray in a patient with Eisenmenger syndrome. (23102605)
2013
12
Successful pregnancy and delivery in a woman with a single ventricle and Eisenmenger syndrome. (24198451)
2013
13
Eisenmenger syndrome in an adult patient with a large patent ductus arteriosus. (24293472)
2013
14
Six-minute walk test distance and resting oxygen saturations but not functional class predict outcome in adult patients with Eisenmenger syndrome. (23962785)
2013
15
Vaginal delivery in a patient of Eisenmenger syndrome. (23897525)
2012
16
Successful pregnancy outcome with eisenmenger syndrome. (23372294)
2012
17
Effects of inhaled iloprost on congenital heart disease with Eisenmenger syndrome. (22349672)
2012
18
The management of Eisenmenger syndrome in the modern treatment era: a case report. (22130823)
2011
19
Oral sildenafil treatment for Eisenmenger syndrome: a prospective, open-label, multicentre study. (21948962)
2011
20
The adult patient with eisenmenger syndrome: a medical update after dana point part I: epidemiology, clinical aspects and diagnostic options. (22043211)
2010
21
Combination therapy with bosentan and sildenafil in Eisenmenger syndrome: a randomized, placebo-controlled, double-blinded trial. (20202971)
2010
22
The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part II: Medical Treatment - Study Results. (22043212)
2010
23
Therapeutic methods used in patients with Eisenmenger syndrome. (19950085)
2009
24
Down patients with Eisenmenger syndrome: is bosentan treatment an option? (18579234)
2009
25
Eisenmenger syndrome--a unique form of pulmonary arterial hypertension. (20196469)
2009
26
Clinical and hemodynamic picture of Eisenmenger syndrome. (20196474)
2009
27
Eisenmenger syndrome: identifying the clues for arrhythmia. (18258531)
2008
28
Kinking of the main stem of the left coronary artery in the setting of Eisenmenger syndrome: an unusual cause of angina pectoris. (17953779)
2008
29
Superior vena cava obstruction due to markedly enlarged right pulmonary artery in Eisenmenger syndrome. (17088314)
2007
30
Adult patients with Eisenmenger syndrome report flying safely on commercial airlines. (17164484)
2007
31
Eisenmenger syndrome: towards identifying the risk factors for death. (16793920)
2006
32
Long-term behavior of endothelial and coagulation markers in Eisenmenger syndrome. (16708119)
2006
33
Update for nurse anesthetists. Eisenmenger syndrome: an anesthetic conundrum. (16786918)
2006
34
Initial experience with Bosentan therapy in patients with the Eisenmenger syndrome: Tetralogy of Fallot? (15670566)
2005
35
Use of long-term combined therapy with inhaled iloprost and oral sildenafil in an adult patient with eisenmenger syndrome. (16230890)
2005
36
Initial experience with bosentan therapy in patients with the Eisenmenger syndrome. (15246919)
2004
37
Pulmonary thrombosis in adults with Eisenmenger syndrome. (14662263)
2003
38
Heart-lung transplantation for Eisenmenger syndrome: early and long-term results. (11789765)
2001
39
Failure of medicine: evolution of an atrial septal defect to an Eisenmenger syndrome. (11041126)
2000
40
Eisenmenger syndrome in pregnancy. (11013476)
2000
41
Eisenmenger syndrome in adults]. (10321257)
1999
42
Noncardiac surgery in Eisenmenger syndrome. (9935034)
1999
43
Images in cardiovascular medicine. Huge dilatation of pulmonary arteries due To ventricular septal defect with the Eisenmenger syndrome. (8941151)
1996
44
Successful pulmonary resection after spontaneous hemopneumothorax in the Eisenmenger syndrome. (1877044)
1991
45
Improvement of exercise capacity after nifedipine in patients with Eisenmenger syndrome complicating ventricular septal defect. (1841020)
1991
46
The anaesthetic management of the Eisenmenger syndrome. (4004057)
1985
47
Eisenmenger syndrome--a clinical and haemodynamic study. (7169456)
1982
48
Eisenmenger syndrome in pregnancy: a possible cause of neonatal polycythemia and persistent fetal circulation. (7145258)
1982
49
Presentation and natural history of Eisenmenger syndrome. (5557481)
1971
50
Atresia of the left atrioventricular valve associated with corrected transposition of the great vessels. A cause of the Eisenmenger syndrome. (14403995)
1960

Variations for Eisenmenger Syndrome

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Expression for genes affiliated with Eisenmenger Syndrome

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Search GEO for disease gene expression data for Eisenmenger Syndrome.

Pathways for genes affiliated with Eisenmenger Syndrome

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Pathways related to Eisenmenger Syndrome according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TGFBR1, TGFBR2
2
Show member pathways
9.2PLAT, THBD, VWF
3
Show member pathways
9.2PLAT, THBD, VWF
49.1BMPR2, TGFBR1, TGFBR2
5
Show member pathways
9.1TGFBR1, TGFBR2, TGFBR3
6
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
7
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
8
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
98.8TGFB1, TGFBR1, TGFBR2
108.8TGFB1, TGFBR1, TGFBR2
118.8TGFB1, TGFBR1, TGFBR2
12
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
13
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
14
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
158.8TGFB1, TGFBR1, TGFBR2
16
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
178.8TGFB1, TGFBR1, TGFBR2
18
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
19
Show member pathways
8.8TGFB1, TGFBR1, TGFBR2
20
Angiogenesis (CST)
Show member pathways
8.7TGFB1, TGFBR1, TGFBR2
21
Show member pathways
8.3BMPR2, TGFB1, TGFBR1, TGFBR2
228.3BMPR2, TGFB1, TGFBR1, TGFBR2
23
TGF-beta signaling pathway (KEGG)
Show member pathways
8.3BMPR2, TGFB1, TGFBR1, TGFBR2
24
Show member pathways
8.3BMPR2, TGFB1, TGFBR1, TGFBR2
25
Show member pathways
8.3TGFB1, TGFBR1, TGFBR2, TGFBR3
268.3TGFB1, TGFBR1, TGFBR2, TGFBR3
278.3TGFB1, TGFBR1, TGFBR2, TGFBR3
28
Show member pathways
8.3TGFB1, TGFBR1, TGFBR2, TGFBR3
298.3TGFB1, TGFBR1, TGFBR2, TGFBR3
308.3TGFB1, TGFBR1, TGFBR2, TGFBR3
318.3TGFB1, TGFBR1, TGFBR2, TGFBR3
32
Show member pathways
7.9EDN1, TGFB1, TGFBR1, TGFBR2, TGFBR3
33
Show member pathways
7.7BMPR2, TGFB1, TGFBR1, TGFBR2, TGFBR3
347.7BMPR2, TGFB1, TGFBR1, TGFBR2, TGFBR3
35
TGF-beta Signaling Pathway (sino)
Show member pathways
7.7BMPR2, TGFB1, TGFBR1, TGFBR2, TGFBR3
367.6PLAT, TGFB1, TGFBR1, TGFBR2, TGFBR3
37
Show member pathways
6.6BMPR2, EDN1, PLAT, TGFB1, TGFBR1, TGFBR2

GO Terms for genes affiliated with Eisenmenger Syndrome

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Cellular components related to Eisenmenger Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Weibel-Palade bodyGO:003309310.4EDN1, VWF
2transforming growth factor beta receptor homodimeric complexGO:007002210.2TGFBR1, TGFBR2
3external side of plasma membraneGO:00098979.6TGFBR2, TGFBR3, VWF
4receptor complexGO:00432359.2TGFBR1, TGFBR2, TGFBR3
5extracellular spaceGO:00056157.3BMPR2, EDN1, PLAT, TGFB1, TGFBR3, THBD
6cell surfaceGO:00099867.0BMPR2, PLAT, TGFB1, TGFBR2, TGFBR3, THBD

Biological processes related to Eisenmenger Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1body fluid secretionGO:000758910.4EDN1, VIP
2negative regulation of blood coagulationGO:003019510.4EDN1, THBD
3regulation of sensory perception of painGO:005193010.3EDN1, VIP
4peptidyl-threonine phosphorylationGO:001810710.1TGFBR1, TGFBR2
5positive regulation of epithelial cell migrationGO:001063410.1BMPR2, TGFBR2
6regulation of protein bindingGO:004339310.1TGFBR1, TGFBR3
7cardiac epithelial to mesenchymal transitionGO:006031710.1TGFBR1, TGFBR3
8transmembrane receptor protein serine/threonine kinase signaling pathwayGO:000717810.1BMPR2, TGFBR1
9activin receptor signaling pathwayGO:003292410.1BMPR2, TGFBR1
10lens development in camera-type eyeGO:000208810.1TGFBR1, TGFBR2
11embryonic cranial skeleton morphogenesisGO:004870110.0TGFBR1, TGFBR2
12common-partner SMAD protein phosphorylationGO:000718210.0TGFB1, TGFBR2
13patterning of blood vesselsGO:00015699.9EDN1, TGFBR2
14positive regulation of SMAD protein import into nucleusGO:00603919.8TGFB1, TGFBR1
15positive regulation of odontogenesisGO:00424829.8EDN1, TGFB1
16positive regulation of bone mineralizationGO:00305019.7BMPR2, TGFB1
17in utero embryonic developmentGO:00017019.7EDN1, TGFBR1, TGFBR2
18signal transduction by protein phosphorylationGO:00230149.7BMPR2, TGFBR1, TGFBR2
19myeloid dendritic cell differentiationGO:00430119.6TGFB1, TGFBR2
20positive regulation of endothelial cell proliferationGO:00019389.6BMPR2, TGFBR1, VIP
21heart developmentGO:00075079.5EDN1, TGFBR1, TGFBR2
22digestive tract developmentGO:00485659.5TGFB1, TGFBR2
23palate developmentGO:00600219.4TGFBR1, TGFBR2, TGFBR3
24response to cholesterolGO:00707239.3TGFB1, TGFBR1, TGFBR2
25cellular response to transforming growth factor beta stimulusGO:00715609.3EDN1, TGFB1, TGFBR1
26epithelial to mesenchymal transitionGO:00018379.3TGFB1, TGFBR1, TGFBR3
27positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.3BMPR2, TGFB1, TGFBR1
28germ cell migrationGO:00083549.2TGFB1, TGFBR1
29organ regenerationGO:00311009.1TGFB1, TGFBR2, TGFBR3
30wound healingGO:00420609.1TGFB1, TGFBR1, TGFBR2
31regulation of cell proliferationGO:00421279.1BMPR2, TGFB1, TGFBR2
32cell growthGO:00160498.9EDN1, TGFB1, TGFBR3
33pathway-restricted SMAD protein phosphorylationGO:00603898.9TGFB1, TGFBR1, TGFBR2, TGFBR3
34negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305128.8TGFB1, TGFBR1, TGFBR2, TGFBR3
35protein phosphorylationGO:00064688.6BMPR2, TGFB1, TGFBR1, TGFBR2
36transforming growth factor beta receptor signaling pathwayGO:00071798.6TGFB1, TGFBR1, TGFBR2, TGFBR3
37regulation of gene expressionGO:00104688.5TGFB1, TGFBR1, TGFBR2
38response to hypoxiaGO:00016668.5EDN1, PLAT, TGFB1, TGFBR3
39positive regulation of cell proliferationGO:00082848.4EDN1, TGFB1, TGFBR1, TGFBR2, VIP
40blood coagulationGO:00075968.3PLAT, TGFB1, THBD, VWF

Molecular functions related to Eisenmenger Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:00198389.8BMPR2, TGFBR1
2type I transforming growth factor beta receptor bindingGO:00347139.7TGFB1, TGFBR2
3type III transforming growth factor beta receptor bindingGO:00347149.6TGFB1, TGFBR2
4transforming growth factor beta-activated receptor activityGO:00050249.5TGFBR1, TGFBR2, TGFBR3
5transmembrane receptor protein serine/threonine kinase activityGO:00046759.4BMPR2, TGFBR1, TGFBR2
6receptor signaling protein serine/threonine kinase activityGO:00047029.4BMPR2, TGFBR1, TGFBR2
7glycosaminoglycan bindingGO:00055399.2TGFBR2, TGFBR3
8transforming growth factor beta bindingGO:00504319.2TGFBR1, TGFBR2, TGFBR3
9SMAD bindingGO:00463329.1TGFBR1, TGFBR2, TGFBR3
10type II transforming growth factor beta receptor bindingGO:00051149.0TGFB1, TGFBR1, TGFBR3
11glycoprotein bindingGO:00019488.7PLAT, TGFB1, VWF

Sources for Eisenmenger Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
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36MeSH
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38MGI
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42NCIt
43NDF-RT
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47Novoseek
49OMIM
50OMIM via Orphanet
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60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet