MCID: ELP001
MIFTS: 36

Elephantiasis malady

Summaries for Elephantiasis

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards: Elephantiasis, also known as elephantiasis nos, is related to filariasis and hydrocele. An important gene associated with Elephantiasis is RNASE3 (ribonuclease, RNase A family, 3). The drug ivermectin and the compounds ozone and n-formylmethionyl-leucylphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone.

Wikipedia:63 Elephantiasis is a syndrome of chronic lymphedema and overlying skin changes. It should not be confused... more...

Aliases & Classifications for Elephantiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

elephantiasis 8 10 44 60
elephantiasis nos 8


External Ids:

Disease Ontology8 DOID:4976
NCIt39 C34569
MeSH34 D004604

Related Diseases for Elephantiasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to elephantiasis

Clinical Features for Elephantiasis

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Drugs & Therapeutics for Elephantiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Elephantiasis

Search CenterWatch for Elephantiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Elephantiasis

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Anatomical Context for Elephantiasis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Elephantiasis:

32
Skin, Lymph node, Bone, Thyroid, Testes, Heart, Breast, Cervix

Animal Models for Elephantiasis or affiliated genes

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Publications for Elephantiasis

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50PubMed
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Articles related to Elephantiasis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
What is your diagnosis? Elephantiasis nostras verrucosa of the back. (23513550)
2013
2
Images in clinical medicine. Elephantiasis neuromatosa. (23635072)
2013
3
Genital elephantiasis due to donovanosis: forgotten but not gone yet ... (23155109)
2012
4
Podoconiosis - non-filarial geochemical elephantiasis - a neglected tropical disease? (20096054)
2010
5
An integrative treatment for lower limb lymphedema (elephantiasis). (20180687)
2010
6
Elephantiasis of the external genitalia: a sequel to cutaneous tuberculosis. (20049271)
2009
7
What is your call?: cobblestone-like skin. Elephantiasis nostras verrucosa. (18809899)
2008
8
Elephantiasis nostras verrucosa or "mossy foot lesions" in lymphedema praecox: report of a case. (18202337)
2008
9
Syphilitic elephantiasis of penis and scrotum. (18270952)
2007
10
The burden of non-filarial elephantiasis in Ethiopia. (17764710)
2007
11
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
12
Prevalence of podoconiosis (endemic non-filarial elephantiasis) in Wolaitta, Southern Ethiopia. (14620426)
2003
13
Congenital elephantiasis-like lymphangiomatosis of a lower limb. (12636021)
2003
14
Adverse reactions following diethylcarbamazine (DEC) intake in 'endemic normals', microfilaraemics and elephantiasis patients. (10492800)
1999
15
Elephantiasis in Pawe settlement area: podoconiosis or bancroftian filariasis? (10214438)
1997
16
Kaposi's sarcoma with elephantiasis associated with AIDS. (7550778)
1995
17
Elephantiasis neuromatosa: a clinicopathologic study of four cases. (1401977)
1992
18
The effects of 5,6 benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India. Preliminary results. (2690762)
1989
19
Angiosarcoma in a limb with arteriovenous fistulas and elephantiasis. (2592800)
1989
20
Facial elephantiasis neurofibromatosa--excision and skin graft. (2516422)
1989
21
The possible role of soil particles in the aetiology of non-filarial (endemic) elephantiasis: a macrophage cytotoxicity assay. (3787683)
1986
22
Verrucous elephantiasis of the scrotum: an unusual variant of genital lymphedema. (3959208)
1986
23
Treatment of elephantiasis in a community with timorian filariasis. (3992641)
1985
24
Pre-elephantiasic stage of endemic nonfilarial elephantiasis of lower legs: "podoconiosis". (6464174)
1984
25
Elephantiasis and its relation to filarial immunity. (7147010)
1982
26
Elephantiasis of the scrotum. (6804519)
1982
27
The long term effects of repeated diethylcarbamazine administration with special reference to microfilaraemia and elephantiasis. (6118029)
1981
28
Endemic elephantiasis of the lower legs as a health hazard of barefooted agriculturalists in Cameroon, West Africa. (7235457)
1981
29
Filarial elephantiasis in French Polynesia: a study concerning the beliefs of 127 patients about the origin of their disease. (45325)
1979
30
Elephantiasis neuromatosa of the penis. Light and electron microscopical studies. (4818737)
1974
31
Elephantiasis and silicates. (4345985)
1972
32
Elephantiasis nostra and elephantiasis tropica: a comparative study. (13691391)
1960
33
The pathogenicity of Onchocerca volvulus in relation to lymphadenopathy and elephantiasis. (13472417)
1957
34
Neurofibromatosis; a case report of elephantiasis neuromatosa of the right lower extremity, with invasion of the popliteal artery. (13354124)
1956
35
Elephantiasis nostras; report of a case. (13268541)
1955
36
ELEPHANTIASIS nostras. (13036197)
1953
37
Surgical treatment of elephantiasis of the lower extremity. (14819502)
1951
38
The surgical treatment of elephantiasis. (15400276)
1950
39
Elephantiasis and the Kondoleon operation; a 20-year postoperative follow-up. (15401946)
1950
40
Elephantiasis nostras nasalis; circumscribed lymphedema of the nose. (14797434)
1950
41
Ptosis with elephantiasis and ectropion. (15425615)
1950
42
Successful removal of an elephantiasis scrotum weighing 70 pounds (35srs.) in a very poor surgical risk case. (15398191)
1949
43
Elephantiasis nostras of external ears. (20277322)
1946
44
A case of elephantiasis treated by primary skin-grafting. (20283936)
1946
45
Elephantiasis Nostras Verrucosa. (19990358)
1935
46
Elephantiasis of the Lip. (19975019)
1911
47
A Peculiar Form of Elephantiasis. (19973496)
1909
48
Two Cases of Elephantiasis graecorum. (19972861)
1908
49
Observations on the Treatment of Elephantiasis Arabum by Ligature of the Main Artery of the Limb: With a Case in which Cure was Effected by Ligature of the External Iliac Artery. (20744930)
1867
50
On a case of Elephantiasis Arabum, or Elephas, successfully treated by the application of a ligature to the main artery of the limb, with remarks. (20896275)
1866

Genetic Variations for Elephantiasis

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Expression for genes affiliated with Elephantiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Elephantiasis

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Pathways for genes affiliated with Elephantiasis

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Compounds for genes affiliated with Elephantiasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Elephantiasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ozone449.7ELN, RNASE3
2n-formylmethionyl-leucylphenylalanine449.6RNASE3, NCF2
3theophylline44 28 11 2412.4ELN, RNASE3
4h2o2449.3ELN, RNASE3, NCF2

GO Terms for genes affiliated with Elephantiasis

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Products for genes affiliated with Elephantiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Elephantiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet