MCID: ELP001
MIFTS: 37

Elephantiasis malady

Categories: Immune diseases

Aliases & Classifications for Elephantiasis

Aliases & Descriptions for Elephantiasis:

Name: Elephantiasis 12 52 3 42 14 69
Elephantiasis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4976
MeSH 42 D004604
NCIt 47 C34569
UMLS 69 C0013882

Summaries for Elephantiasis

CDC : 3 Lymphatic filariasis, considered globally as a neglected tropical disease , is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards based summary : Elephantiasis, also known as elephantiasis nos, is related to filarial elephantiasis and podoconiosis. An important gene associated with Elephantiasis is NF1 (Neurofibromin 1), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. The drugs Albendazole and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes.

Wikipedia : 71 Elephantiasis is a symptom of a variety of diseases, where parts of a person\'s body swell to massive... more...

Related Diseases for Elephantiasis

Diseases related to Elephantiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
id Related Disease Score Top Affiliating Genes
1 filarial elephantiasis 12.3
2 podoconiosis 11.4
3 hydrocele 11.2
4 lymphedema 10.2
5 dancing eyes-dancing feet syndrome 10.2 ELANE ELN
6 benign focal seizures of adolescence 10.2 ELANE ELN
7 tetanus 10.2 ELANE ELN
8 choroid plexus cancer 10.2 ELN NF1
9 bardet-biedl syndrome 8 10.2 ELANE ELN
10 alcoholic hepatitis 10.1 ELANE ELN
11 infectious anterior uveitis 10.1 ELANE RNASE3
12 renal oncocytoma 10.1 ELANE ELN
13 calpainopathy 10.1 ELANE RNASE3
14 acute dacryoadenitis 10.1 ELANE RNASE3
15 filariasis 10.0
16 familial renal papillary carcinoma 10.0 ELANE RNASE3
17 mixed ductal-endocrine carcinoma 10.0 ELANE ELN
18 spontaneous ocular nystagmus 10.0 ELANE RNASE3
19 acute chest syndrome 10.0 ELANE RNASE3
20 lymphangitis 10.0
21 46 xy gonadal dysgenesis 10.0 MFF SRCIN1
22 median arcuate ligament syndrome 10.0 MFF SRCIN1
23 retinitis pigmentosa 51 10.0 ELANE ELN RNASE3
24 obesity 10.0
25 neurofibromatosis 10.0
26 hyperparathyroidism 10.0 MFF SRCIN1
27 inclusion conjunctivitis 10.0 MFF SRCIN1
28 hyperlysinemia 9.9 ELANE ELN RNASE3
29 bare lymphocyte syndrome, type i 9.9 ELANE RNASE3
30 lymphadenitis 9.8
31 hidradenitis suppurativa 9.8
32 hidradenitis 9.8
33 morbid obesity 9.8
34 onchocerciasis 9.8
35 lymphangiosarcoma 9.8
36 tuberculosis 9.8
37 neurofibroma 9.8
38 neurofibromatosis, type 1 9.7
39 venous insufficiency 9.7
40 sarcoma 9.7
41 erysipelas 9.7
42 graves' disease 9.7
43 lymphogranuloma venereum 9.7
44 thyroiditis 9.7
45 actinic keratosis 9.6 GPT2 MFF RNASE3 SRCIN1
46 leprosy 9.5
47 kaposi sarcoma 9.5
48 arteriovenous fistula 9.5
49 burns 9.5
50 congestive heart failure 9.5

Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to Elephantiasis

Symptoms & Phenotypes for Elephantiasis

Drugs & Therapeutics for Elephantiasis

Drugs for Elephantiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
2
Ivermectin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 6474909 46936176
3
Diethylcarbamazine Approved, Vet_approved Phase 4,Phase 2,Phase 1 90-89-1 3052
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
5
Praziquantel Approved, Vet_approved Phase 4 55268-74-1 4891
6
Azithromycin Approved Phase 4,Phase 2 83905-01-5 55185 53477736 447043
7 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
10 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Lipoxygenase Inhibitors Phase 4,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Antimalarials Phase 4,Phase 3,Phase 2
15 Anticonvulsants Phase 4
16
Glycerol Approved, Experimental Phase 3 56-81-5 753
17
Petrolatum Approved Phase 3 8009-03-8
18 Disinfectants Phase 3
19 Eusol Phase 3
20 Protective Agents Phase 3
21 Sodium hypochlorite Phase 3
22 Milbemycin Phase 3,Phase 2
23 Vitamins Phase 3
24
Rifampin Approved Phase 2 13292-46-1 5458213 5381226
25 Artemisinine Phase 2
26 Artemisinins Phase 2
27
Dihydroartemisinin Phase 2 71939-50-9 6918483
28
Piperaquine Phase 2 4085-31-8 5079497
29 Antibiotics, Antitubercular Phase 2
30 Antitubercular Agents Phase 2
31 Cytochrome P-450 CYP3A Inducers Phase 2
32 Nucleic Acid Synthesis Inhibitors Phase 2
33 Antibodies Phase 2
34 Antibodies, Monoclonal Phase 2
35 Immunoglobulins Phase 2
36 Imatinib Mesylate Phase 2 123596
37 Protein Kinase Inhibitors Phase 2
38
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
39
Suramin Approved 145-63-1 5361
40
Mebendazole Approved, Vet_approved 31431-39-7 4030
41
Piperazine Approved, Vet_approved 110-85-0 4837
42 Piperazine citrate
43 Citrate Nutraceutical
44
Citric Acid Nutraceutical, Vet_approved 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 55)
id Name Status NCT ID Phase
1 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4
2 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4
3 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4
4 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4
5 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Not yet recruiting NCT03014167 Phase 4
6 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4
7 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Not yet recruiting NCT03052998 Phase 4
8 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4
9 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
10 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3
11 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3
12 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Not yet recruiting NCT02929134 Phase 3
13 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3
14 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3
15 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Not yet recruiting NCT02078024 Phase 3
16 Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Completed NCT00511004 Phase 2
17 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2
18 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00339417 Phase 2
19 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00375583 Phase 2
20 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2
21 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2
22 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2
23 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2
24 Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Active, not recruiting NCT01975441 Phase 2
25 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Active, not recruiting NCT01111305 Phase 2
26 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2
27 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2
28 First in Man Clinical Trial of Emodepside (BAY 44-4400) Recruiting NCT02661178 Phase 1
29 Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE) Active, not recruiting NCT02845713 Phase 1
30 Exhaled NO Testing in Filariasis Completed NCT01628497
31 Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Completed NCT01629771
32 Research for Elim of Filariasis Completed NCT00145223
33 Research for Elimination of Lymphatic Filariasis (ICIDR) Completed NCT00406627
34 Interaction Between HIV and Lymphatic Filariasis Completed NCT00295698
35 Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area Completed NCT00139100
36 Medical Implications of Coinfection With Malaria and Filariasis Parasites Completed NCT00471666
37 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169
38 Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis Completed NCT00344279
39 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
40 Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites Completed NCT00341666
41 Safety and Efficacy of Drug Combinations Against Triple Infections Completed NCT01050517
42 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
43 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
44 Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280
45 Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis Recruiting NCT02899936
46 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Recruiting NCT02032043
47 Effect of Filarial Infection on Immune Responses in Latent Tuberculosis Recruiting NCT01547884
48 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
49 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Active, not recruiting NCT01905423
50 Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia Active, not recruiting NCT01905436

Search NIH Clinical Center for Elephantiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: elephantiasis

Genetic Tests for Elephantiasis

Anatomical Context for Elephantiasis

MalaCards organs/tissues related to Elephantiasis:

39
Skin, Lymph Node, Testes, Bone, Thyroid, Heart, Cervix

Publications for Elephantiasis

Articles related to Elephantiasis:

(show top 50) (show all 431)
id Title Authors Year
1
Giant elephantiasis neuromatosa in the setting of neurofibromatosis type 1: A case report. ( 27284375 )
2016
2
Elephantiasis nostras verrucosa secondary to congestive cardiac failure. ( 26944379 )
2016
3
Elephantiasis Nostras Verrucosa. Excision with full-thickness skin grafting of the penis, scrotum, and perineal area. ( 27900063 )
2016
4
Abdominal Elephantiasis Nostras Verrucosa: An Underrecognized Disorder. ( 27784526 )
2016
5
Evolution of Skin during Rehabilitation for Elephantiasis Using Intensive Treatment. ( 27999691 )
2016
6
Successful Surgical Treatment for Elephantiasis Nostras Verrucosa Using a New Designed Column Flap. ( 25573979 )
2015
7
Vulval elephantiasis. ( 26500880 )
2015
8
Resolution of septic shock in a patient with myelomeningocele (spina bifida) complicated with deforming Elephantiasis Nostras Verrucosa. ( 25623264 )
2015
9
Scrotal elephantiasis secondary to recalcitrant hidradenitis suppurativa. ( 26087097 )
2015
10
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. ( 26119541 )
2015
11
Elephantiasis nostras verrucosa occurring in voluntary shut-in ("hikikomori"). ( 25500212 )
2015
12
Massive Soft Tissue Neurofibroma (Elephantiasis Neuromatosa): Case Report and Review of Literature. ( 25694465 )
2015
13
Liposuction Normalizes Lymphedema Induced Adipose Tissue Hypertrophy in Elephantiasis of the Leg - A Prospective Study with a Ten-Year Follow-Up. ( 26397659 )
2015
14
A case of progressive elephantiasis nostras verrucosa. ( 25832960 )
2015
15
Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy? ( 26281791 )
2015
16
Scroto-perineal hidradenitis suppurativa complicated by giant scrotal elephantiasis. ( 25837812 )
2015
17
The diagnostic challenge of mapping elephantiasis in the Tigray region of northern Ethiopia. ( 26518364 )
2015
18
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. ( 25059525 )
2014
19
Excision of Elephantiasis Nostras Verrucosa Lesions in a Patient With Hereditary Lymphedema: Case Report and Review of the Literature. ( 25441846 )
2014
20
Photoclinic. Elephantiasis nostras verrucosa secondary to lymphedema praecox. ( 24979570 )
2014
21
Elephantiasis nostras verrucosa as a manifestation of morbid obesity. ( 25406220 )
2014
22
NF1 truncating mutations associated to aggressive clinical phenotype with elephantiasis neuromatosa and solid malignancies. ( 24922668 )
2014
23
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. ( 24946801 )
2014
24
Recurrent unilateral vulval elephantiasis: a case report. ( 24971141 )
2014
25
Elephantiasis nostras verrucosa of lower limb: a case report. ( 25369015 )
2014
26
Images in clinical medicine. Elephantiasis nostras verrucosa. ( 24963571 )
2014
27
Debulking surgery for elephantiasis nostras with large ectatic podoplanin-negative lymphatic vessels in patients with lipo-lymphedema. ( 24741382 )
2014
28
Elephantiasis nostras verrucosa. ( 24682133 )
2014
29
A surgical challenge: Idiopathic scrotal elephantiasis. ( 25132898 )
2014
30
Elephantiasis nostras verrucosa. ( 24856044 )
2014
31
Maggot Therapy for Elephantiasis Nostras Verrucosa Reveals New Applications and New Complications: A Case Report. ( 24861094 )
2014
32
Obesity-associated abdominal elephantiasis. ( 23606857 )
2013
33
Elephantiasis nostras verrucosa in a patient with obesity and chronic venous insufficiency. ( 23432135 )
2013
34
Images in clinical medicine. Elephantiasis neuromatosa. ( 23635072 )
2013
35
What is your diagnosis? Elephantiasis nostras verrucosa of the back. ( 23513550 )
2013
36
Double autologous lymph node transplantation (ALNT) at the level of the knee and inguinal region for advanced lymphoedema of the lower limb (elephantiasis). ( 24269710 )
2013
37
Penile elephantiasis: a rare consequence of inappropriate use of condom as external urinary collection receptacle. ( 23355598 )
2013
38
Giant penile elephantiasis after circumcision: a devastating complication. ( 24042209 )
2013
39
Elephantiasis nostras verrucosa: swelling with verrucose appearance of lower limbs. ( 23064932 )
2012
40
A case of elephantiasis nostras verrucosa treated by acitretin. ( 22395594 )
2012
41
Control of lymphorrhea and treatment of warty excrescences in elephantiasis. ( 23259091 )
2012
42
A brief history of elephantiasis. ( 22715171 )
2012
43
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. ( 22487446 )
2012
44
Verruciform xanthoma: localized lymphedema (elephantiasis) is an essential pathogenic factor. ( 21362016 )
2012
45
Vulval elephantiasis: a case report. ( 23198192 )
2012
46
Intensive outpatient treatment of elephantiasis. ( 22990514 )
2012
47
Genital elephantiasis due to donovanosis: forgotten but not gone yet ... ( 23155109 )
2012
48
Elephantiasis nostras verrucosa: a rare case of thyroid dermopathy. ( 22960831 )
2012
49
Elephantiasis Legs. ( 23114202 )
2012
50
Elephantiasis nostras verrucosa. ( 23150746 )
2012

Variations for Elephantiasis

Expression for Elephantiasis

Search GEO for disease gene expression data for Elephantiasis.

Pathways for Elephantiasis

Pathways related to Elephantiasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.21 ELANE ELN

GO Terms for Elephantiasis

Cellular components related to Elephantiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 ELANE RNASE3

Biological processes related to Elephantiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.26 ELANE ELN
2 antimicrobial humoral response GO:0019730 9.16 ELANE RNASE3
3 skeletal muscle tissue development GO:0007519 8.96 ELN NF1
4 cell communication GO:0007154 8.62 GJC2 NF1

Sources for Elephantiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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