MCID: ELP001
MIFTS: 36

Elephantiasis malady

Summaries for Elephantiasis

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards: Elephantiasis, also known as elephantiasis nos, is related to filariasis and hydrocele. An important gene associated with Elephantiasis is RNASE3 (ribonuclease, RNase A family, 3). The drug ivermectin and the compounds ozone and n-formylmethionyl-leucylphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone.

Wikipedia:63 Elephantiasis is a syndrome of chronic lymphedema and overlying skin changes. It should not be confused... more...

Aliases & Classifications for Elephantiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

elephantiasis 8 10 44 60
elephantiasis nos 8


External Ids:

Disease Ontology8 DOID:4976
NCIt39 C34569
MeSH34 D004604

Related Diseases for Elephantiasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to elephantiasis

Clinical Features for Elephantiasis

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Drugs & Therapeutics for Elephantiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Elephantiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Elephantiasis

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Anatomical Context for Elephantiasis

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32MalaCards
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MalaCards organs/tissues related to Elephantiasis:

32
Skin, Lymph node, Bone, Thyroid, Testes, Heart, Breast, Cervix

Animal Models for Elephantiasis or affiliated genes

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Publications for Elephantiasis

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50PubMed
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Articles related to Elephantiasis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Intensive outpatient treatment of elephantiasis. (22990514)
2012
2
Comparative dermatology: elephantiasis nostra in verrucous form comparable to coral. (21987163)
2011
3
Elephantiasis nostras verrucosa: an institutional analysis of 21 cases. (21440328)
2011
4
Genital elephantiasis as a complication of chromoblastomycosis: A diagnosis overlooked. (21938115)
2009
5
Structural characteristics of 'Hayward' kiwifruits from elephantiasis-affected plants studied by DRIFT, FT-Raman, NMR, and SEM techniques. (19413311)
2009
6
Elephantiasis nostras verrucosa on the legs and abdomen with morbid obesity in an Indian lady. (19265633)
2008
7
Giant scrotal elephantiasis of inflammatory etiology: a case report. (17543128)
2007
8
Evaluation of the pathology, pathogenesis and aetiology of auricular elephantiasis in slaughter pigs. (12549830)
2002
9
Genital elephantiasis. (12015020)
2002
10
Elephantiasis nostras verrucosa. (11095196)
2000
11
Bone scintigraphy of elephantiasis neuromatosa in Von Recklinghausen's disease. (11043722)
2000
12
Scarification as a risk factor for rapid progression of filarial elephantiasis. (9373650)
1997
13
Chronic elephantiasis. A case report. (7776217)
1995
14
Elephantiasis in SALo TomAc and PrA-ncipe. (7942352)
1994
15
Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC). (8257235)
1993
16
Elephantiasis nostras. (1563290)
1992
17
Angioedema, elephantiasis nostras, and cheilitis granulomatosa. (2338241)
1990
18
Filarial lymphoedema and elephantiasis of lower limb: a review of 44 cases. (3719269)
1986
19
Elephantiasis of the penis and scrotum. A review of 350 cases. (3993854)
1985
20
Classics in oncology: lymphangiosarcoma in postmastectomy lymphedema: a report of six cases in elephantiasis chirurgica. (6793218)
1981
21
The elemental content of lymphatic tissues of barefooted people in Ethiopia, with reference to endemic elephantiasis of the lower legs. (653784)
1978
22
Elephantiasis of eyelids following repeated craniotomy. Case report. (874554)
1977
23
Alkaloids and coumarins of Zanthoxylum elephantiasis [proceedings]. (12347)
1976
24
Endemic elephantiasis of the lower legs--natural history and clinical study. (4818661)
1974
25
The mineral content of inguinal nodes in barefoot people with and without elephantiasis of the legs. (4355230)
1973
26
Surgical treatment of elephantiasis of male genitalia. (4919285)
1970
27
Researches on elephantiasis nostras and elephantiasis tropica with special regard to their initial stage of recurring lymphangitis (lymphangitis recurrens elephantogenica). (5377701)
1969
28
Elephantiasis and Polynesian origins. (4874915)
1968
29
Elephantiasis tropica. (5988600)
1966
30
Elephantiasis gingivae. Report of an affected family with associated hepatomegaly, soft tissue & skeletal abnormalities. (5216911)
1965
31
Topographical distribution of mast cells in human skin. Pathogenesis of tropical elephantiasis. (13944808)
1962
32
Non-bancroftian elephantiasis in Tanganyika. (13276677)
1956
33
Delpech: his contributions to plastic surgery and the astonishing case of scrotal elephantiasis. (13315969)
1956
34
Notes on elephantiasis and hydrocoele due to Wuchereria bancrofti. (14368667)
1955
35
Elephantiasis nostras. (13118728)
1954
36
The effect of adrenocorticotropic hormone on elephantiasis of the lower limb. (13113666)
1953
37
An unusual case of congenital elephantiasis. (14944780)
1952
38
Prophylaxis of postmammectomy lymphedema by the use of gelfoam laminated rolls; a preliminary report, with a review of the theories on the etiology of elephantiasis chirurgica and a summary of previous operations for its control. (14886900)
1952
39
Massive nonfilarial genital elephantiasis; report of a unusual case. (18152295)
1949
40
Surgical treatment of elephantiasis of the lower extremities. (18144011)
1949
41
Surgical treatment of acrotal elephantiasis in West Africa. (15398686)
1949
42
Congenital Elephantiasis. (19992817)
1944
43
Pseudo-elephantiasis: Milroy's Disease. (19990880)
1936
44
ELEPHANTIASIS AND THE CLINICAL IMPLICATIONS OF ITS EXPERIMENTAL REPRODUCTION IN ANIMALS. (17856398)
1934
45
Syphilitic Pseudo-elephantiasis. (19984336)
1925
46
Case of Post-operative Elephantiasis of the Finger. (19979581)
1917
47
Syphilitic Elephantiasis of the Scrotum (Lymphangitis). (19975808)
1912
48
THE OPERATION FOR ELEPHANTIASIS SCROTI. (20764946)
1910
49
ELEPHANTIASIS. (20760223)
1902
50
A Case of Elephantiasis Telangiec-Todes and Molluscum Fibrosum. (20752903)
1890

Genetic Variations for Elephantiasis

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Expression for genes affiliated with Elephantiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Elephantiasis

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Pathways for genes affiliated with Elephantiasis

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Compounds for genes affiliated with Elephantiasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Elephantiasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ozone449.7ELN, RNASE3
2n-formylmethionyl-leucylphenylalanine449.6RNASE3, NCF2
3theophylline44 28 11 2412.4ELN, RNASE3
4h2o2449.3ELN, RNASE3, NCF2

GO Terms for genes affiliated with Elephantiasis

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Products for genes affiliated with Elephantiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Elephantiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet