Aliases & Classifications for Elephantiasis

MalaCards integrated aliases for Elephantiasis:

Name: Elephantiasis 12 72 51 3 41 14 69
Elephantiasis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4976
MeSH 41 D004604
NCIt 46 C34569
UMLS 69 C0013882

Summaries for Elephantiasis

CDC : 3 Lymphatic filariasis, considered globally as a neglected tropical disease , is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards based summary : Elephantiasis, also known as elephantiasis nos, is related to erysipelas and filarial elephantiasis. An important gene associated with Elephantiasis is NF1 (Neurofibromin 1), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. The drugs Albendazole and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and liver.

Wikipedia : 72 Elephantiasis is a symptom of a variety of diseases, where parts of a person\'s body swell to massive... more...

Related Diseases for Elephantiasis

Diseases related to Elephantiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 erysipelas 30.2 ELANE ELN
2 filarial elephantiasis 12.5
3 podoconiosis 12.0
4 hydrocele 11.3
5 cerebral aneurysms 10.3 ELANE ELN
6 mid-dermal elastolysis 10.3 ELANE ELN
7 cerebral arterial disease 10.3 ELN NF1
8 lymphedema 10.3
9 alpha-1-antitrypsin deficiency 10.3 ELANE ELN
10 status asthmaticus 10.2 ELANE RNASE3
11 pulmonary emphysema 10.2 ELANE ELN
12 neurofibrosarcoma 10.2 INSRR NF1
13 adult respiratory distress syndrome 10.2 ELANE ELN
14 bronchopulmonary dysplasia 10.2 ELANE RNASE3
15 leukocyte disease 10.2 ELANE RNASE3
16 filariasis 10.1
17 bronchial disease 10.1 ELANE RNASE3
18 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 ELANE RNASE3
19 cellulitis 10.1 GJC2 RNASE3
20 aortic aneurysm, familial abdominal, 1 10.1 ELANE ELN
21 lymphangitis 10.1
22 bronchitis 10.1 ELANE RNASE3
23 autosomal genetic disease 10.1 ELANE NF1
24 neurofibromatosis, type iv, of riccardi 10.1
25 body mass index quantitative trait locus 11 10.1
26 body mass index quantitative trait locus 9 10.1
27 body mass index quantitative trait locus 8 10.1
28 body mass index quantitative trait locus 7 10.1
29 body mass index quantitative trait locus 12 10.1
30 body mass index quantitative trait locus 14 10.1
31 body mass index quantitative trait locus 18 10.1
32 loiasis 10.1 MFF SRCIN1
33 sclerosing keratitis 10.0 MFF SRCIN1
34 deep keratitis 10.0 MFF SRCIN1
35 body mass index quantitative trait locus 4 10.0
36 body mass index quantitative trait locus 10 10.0
37 pulmonary disease, chronic obstructive 10.0 ELANE ELN RNASE3
38 anterior scleritis 10.0 MFF SRCIN1
39 respiratory system disease 9.9 ELANE RNASE3
40 lymphadenitis 9.9
41 hidradenitis suppurativa 9.9
42 hidradenitis 9.9
43 mycobacterium tuberculosis 1 9.9
44 morbid obesity 9.9
45 onchocerciasis 9.9
46 lymphangiosarcoma 9.9
47 neurofibroma 9.9
48 wegener granulomatosis 9.8 ELANE ELN
49 blood group, vel system 9.8
50 venous insufficiency 9.8

Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to Elephantiasis

Symptoms & Phenotypes for Elephantiasis

Drugs & Therapeutics for Elephantiasis

Drugs for Elephantiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
2
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 46936176 6474909
3
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 90-89-1 3052
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
5
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 1 55268-74-1 4891
6
Azithromycin Approved Phase 4,Phase 2 83905-01-5 53477736 447043 55185
7 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
10 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Lipoxygenase Inhibitors Phase 4,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Antimalarials Phase 4,Phase 3,Phase 2
15 Anticonvulsants Phase 4
16
Glycerol Approved, Investigational Phase 3 56-81-5 753
17
Petrolatum Approved, Investigational Phase 3 8009-03-8
18 Disinfectants Phase 3
19 Eusol Phase 3
20 Protective Agents Phase 3
21 Sodium hypochlorite Phase 3
22 Vitamins Phase 3
23 Milbemycin Phase 3,Phase 2
24
Rifampin Approved Phase 2 13292-46-1 5381226 5458213
25 Artemisinine Phase 2
26 Artemisinins Phase 2
27
Dihydroartemisinin Phase 2 71939-50-9 6918483
28
Piperaquine Phase 2 4085-31-8 5079497
29 Anti-Asthmatic Agents Phase 2
30 Antibodies Phase 2
31 Antibodies, Monoclonal Phase 2
32 Immunoglobulins Phase 2
33 Respiratory System Agents Phase 2
34 Antibiotics, Antitubercular Phase 2
35 Antitubercular Agents Phase 2
36 Cytochrome P-450 CYP3A Inducers Phase 2
37 Nucleic Acid Synthesis Inhibitors Phase 2
38 Imatinib Mesylate Phase 2 123596
39 Protein Kinase Inhibitors Phase 2
40
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
41 Pharmaceutical Solutions Phase 1
42
Mebendazole Approved, Vet_approved 31431-39-7 4030
43
Piperazine Approved, Vet_approved 110-85-0 4837
44
Permethrin Approved, Investigational 52645-53-1 40326
45
Suramin Approved, Investigational 145-63-1 5361
46
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
47 Piperazine citrate
48 Liver Extracts
49 Citrate Nutraceutical

Interventional clinical trials:

(show top 50) (show all 60)

# Name Status NCT ID Phase Drugs
1 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
2 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4 Diethylcarbamazine;Ivermectin
3 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4 Diethylcarbamazine;Albendazole;Doxycycline
4 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
5 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Not yet recruiting NCT03014167 Phase 4 Albendazole
6 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4 Praziquantel
7 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Not yet recruiting NCT03052998 Phase 4 Ivermectin
8 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
9 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
10 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
11 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
12 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
13 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
14 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
15 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
16 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3 Doxycycline;Placebo
17 Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Completed NCT00511004 Phase 2 Albendazole;Diethylcarbamazine
18 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2 Doxycycline
19 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00339417 Phase 2 Albendazole;Ivermectin
20 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00375583 Phase 2 DEC/Albendazole
21 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
22 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Completed NCT01111305 Phase 2 Reslizumab;Diethylcarbamazine
23 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
24 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
25 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2 Doxycycline
26 Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Active, not recruiting NCT01975441 Phase 2 Diethylcarbamazine;Albendazole;Ivermectin
27 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
28 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
29 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
30 Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside Recruiting NCT03383614 Phase 1 LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
31 Relative Bioavailability Study of Emodepside IR-tablets and Solution Recruiting NCT03383523 Phase 1 Emodepside (BAY 44-4400)
32 Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE) Active, not recruiting NCT02845713 Phase 1 Ivermectin, Diethylcarbamazine Albendazole (IDA)
33 Exhaled NO Testing in Filariasis Completed NCT01628497
34 Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Completed NCT01629771
35 Research for Elim of Filariasis Completed NCT00145223
36 Research for Elimination of Lymphatic Filariasis (ICIDR) Completed NCT00406627
37 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Completed NCT01905423 Albendazole and diethylcarbamazine
38 Interaction Between HIV and Lymphatic Filariasis Completed NCT00295698 Diethylcarbamazine
39 Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area Completed NCT00139100 antimicrobial agent in soap
40 Medical Implications of Coinfection With Malaria and Filariasis Parasites Completed NCT00471666
41 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
42 Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis Completed NCT00344279
43 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
44 Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites Completed NCT00341666
45 Safety and Efficacy of Drug Combinations Against Triple Infections Completed NCT01050517 albendazole + ivermectin + praziquantel;albendazole + ivermectin + (1 week later) praziquantel
46 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
47 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
48 Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280 ivermectin and albendazole
49 Prevalence Studies After Triple Drug Therapy for Lymphatic Filariasis Recruiting NCT03352206 2 drug dose - DA;3 drug dose - IDA
50 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Recruiting NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA

Search NIH Clinical Center for Elephantiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: elephantiasis

Genetic Tests for Elephantiasis

Anatomical Context for Elephantiasis

MalaCards organs/tissues related to Elephantiasis:

38
Skin, Testes, Liver, Lymph Node, Bone, Thyroid, Cervix

Publications for Elephantiasis

Articles related to Elephantiasis:

(show top 50) (show all 439)
# Title Authors Year
1
Podoconiosis: Nonfilarial endemic elephantiasis. ( 29371058 )
2018
2
Wuchereria bancrofti infection at four primary schools and surrounding communities with no previous blood surveys in northern Uganda: the prevalence after mass drug administrations and a report on suspected non-filarial endemic elephantiasis. ( 28814926 )
2017
3
Elephantiasis nostras verrucosa: a rare complication of lower limb lymphoedema. ( 28847994 )
2017
4
Beta Human Papillomavirus Infection Is Prevalent in Elephantiasis and Exhibits a Productive Phenotype: A Case-Control Study. ( 28253203 )
2017
5
Elephantiasis nostras verrucosa. ( 29067989 )
2017
6
Giant elephantiasis and inguino-scrotal hernia. ( 28617809 )
2017
7
A Case of Exuberant Elephantiasis Nostras Verrucosa. ( 28865510 )
2017
8
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
9
Abdominal Elephantiasis Nostras Verrucosa: An Underrecognized Disorder. ( 27784526 )
2016
10
Evolution of Skin during Rehabilitation for Elephantiasis Using Intensive Treatment. ( 27999691 )
2016
11
Giant elephantiasis neuromatosa in the setting of neurofibromatosis type 1: A case report. ( 27284375 )
2016
12
Elephantiasis nostras verrucosa secondary to congestive cardiac failure. ( 26944379 )
2016
13
Elephantiasis Nostras Verrucosa. Excision with full-thickness skin grafting of the penis, scrotum, and perineal area. ( 27900063 )
2016
14
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. ( 26119541 )
2015
15
Elephantiasis nostras verrucosa occurring in voluntary shut-in ("hikikomori"). ( 25500212 )
2015
16
The diagnostic challenge of mapping elephantiasis in the Tigray region of northern Ethiopia. ( 26518364 )
2015
17
Scrotal elephantiasis secondary to recalcitrant hidradenitis suppurativa. ( 26087097 )
2015
18
Scroto-perineal hidradenitis suppurativa complicated by giant scrotal elephantiasis. ( 25837812 )
2015
19
Resolution of septic shock in a patient with myelomeningocele (spina bifida) complicated with deforming Elephantiasis Nostras Verrucosa. ( 25623264 )
2015
20
Vulval elephantiasis. ( 26500880 )
2015
21
A case of progressive elephantiasis nostras verrucosa. ( 25832960 )
2015
22
Successful Surgical Treatment for Elephantiasis Nostras Verrucosa Using a New Designed Column Flap. ( 25573979 )
2015
23
Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy? ( 26281791 )
2015
24
Liposuction Normalizes Lymphedema Induced Adipose Tissue Hypertrophy in Elephantiasis of the Leg - A Prospective Study with a Ten-Year Follow-Up. ( 26397659 )
2015
25
Massive Soft Tissue Neurofibroma (Elephantiasis Neuromatosa): Case Report and Review of Literature. ( 25694465 )
2015
26
Maggot Therapy for Elephantiasis Nostras Verrucosa Reveals New Applications and New Complications: A Case Report. ( 24861094 )
2014
27
Elephantiasis nostras verrucosa of lower limb: a case report. ( 25369015 )
2014
28
Elephantiasis nostras verrucosa. ( 24682133 )
2014
29
Elephantiasis nostras verrucosa. ( 24856044 )
2014
30
Photoclinic. Elephantiasis nostras verrucosa secondary to lymphedema praecox. ( 24979570 )
2014
31
Debulking surgery for elephantiasis nostras with large ectatic podoplanin-negative lymphatic vessels in patients with lipo-lymphedema. ( 24741382 )
2014
32
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. ( 24946801 )
2014
33
Recurrent unilateral vulval elephantiasis: a case report. ( 24971141 )
2014
34
A surgical challenge: Idiopathic scrotal elephantiasis. ( 25132898 )
2014
35
Elephantiasis nostras verrucosa as a manifestation of morbid obesity. ( 25406220 )
2014
36
Images in clinical medicine. Elephantiasis nostras verrucosa. ( 24963571 )
2014
37
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. ( 25059525 )
2014
38
NF1 truncating mutations associated to aggressive clinical phenotype with elephantiasis neuromatosa and solid malignancies. ( 24922668 )
2014
39
Excision of Elephantiasis Nostras Verrucosa Lesions in a Patient With Hereditary Lymphedema: Case Report and Review of the Literature. ( 25441846 )
2014
40
Elephantiasis nostras verrucosa in a patient with obesity and chronic venous insufficiency. ( 23432135 )
2013
41
What is your diagnosis? Elephantiasis nostras verrucosa of the back. ( 23513550 )
2013
42
Penile elephantiasis: a rare consequence of inappropriate use of condom as external urinary collection receptacle. ( 23355598 )
2013
43
Double autologous lymph node transplantation (ALNT) at the level of the knee and inguinal region for advanced lymphoedema of the lower limb (elephantiasis). ( 24269710 )
2013
44
Images in clinical medicine. Elephantiasis neuromatosa. ( 23635072 )
2013
45
Giant penile elephantiasis after circumcision: a devastating complication. ( 24042209 )
2013
46
Obesity-associated abdominal elephantiasis. ( 23606857 )
2013
47
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. ( 22487446 )
2012
48
A brief history of elephantiasis. ( 22715171 )
2012
49
Elephantiasis nostras verrucosa. ( 23150746 )
2012
50
Vulval elephantiasis: a case report. ( 23198192 )
2012

Variations for Elephantiasis

Expression for Elephantiasis

Search GEO for disease gene expression data for Elephantiasis.

Pathways for Elephantiasis

Pathways related to Elephantiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 ELANE ELN

GO Terms for Elephantiasis

Cellular components related to Elephantiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 ELANE RNASE3

Biological processes related to Elephantiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.26 ELANE ELN
2 antimicrobial humoral response GO:0019730 9.16 ELANE RNASE3
3 skeletal muscle tissue development GO:0007519 8.96 ELN NF1
4 cell communication GO:0007154 8.62 GJC2 NF1

Sources for Elephantiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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