MCID: ELP001
MIFTS: 36

Elephantiasis malady

Summaries for Elephantiasis

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards: Elephantiasis, also known as elephantiasis nos, is related to filariasis and hydrocele. An important gene associated with Elephantiasis is RNASE3 (ribonuclease, RNase A family, 3). The drug ivermectin and the compounds ozone and n-formylmethionyl-leucylphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes.

Wikipedia:63 Elephantiasis is a syndrome of chronic lymphedema and overlying skin changes. It should not be confused... more...

Aliases & Classifications for Elephantiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

elephantiasis 8 10 44 60
elephantiasis nos 8


External Ids:

Disease Ontology8 DOID:4976
NCIt39 C34569
MeSH34 D004604

Related Diseases for Elephantiasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to elephantiasis

Clinical Features for Elephantiasis

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Drugs & Therapeutics for Elephantiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Elephantiasis

Search NIH Clinical Center for Elephantiasis

Search CenterWatch for Elephantiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Elephantiasis

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Anatomical Context for Elephantiasis

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32MalaCards
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MalaCards organs/tissues related to Elephantiasis:

32
Skin, Lymph node, Testes, Bone, Thyroid, Heart, Breast, Cervix

Animal Models for Elephantiasis or affiliated genes

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Publications for Elephantiasis

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50PubMed
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Articles related to Elephantiasis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
A brief history of elephantiasis. (22715171)
2012
2
Vulval elephantiasis: a case report. (23198192)
2012
3
Bancroftian elephantiasis in Nilphamari, Bangladesh. (21240161)
2011
4
Elephantiasis Nostras Verrucosa (ENV): a complication of congestive heart failure and obesity. (20453188)
2010
5
Elephantiasis nostras verrucosa: successful surgical treatment in a gross deformity. (20101321)
2009
6
Huge filarial elephantiasis vulvae in a Nigerian woman with subfertility. (18368416)
2008
7
Surgical repair of idiopathic scrotal elephantiasis. (18364628)
2008
8
A systematic multiple stage surgical approach for attainment of satisfactory and favourable surgical results in an extremely severe von Recklinghausen's disease, elephantiasis neurofibromatosa. (16817261)
2006
9
Elephantiasis nostras verrucosa. (16988176)
2006
10
Giant scrotal elephantiasis. (15708070)
2005
11
Penile and scrotal elephantiasis caused by indolent Chlamydia trachomatis infection. (12559311)
2003
12
Bilateral groove sign with penoscrotal elephantiasis. (12473811)
2002
13
Inguinal syndrome with penoscrotal elephantiasis. (17657009)
2002
14
Images in vascular medicine. Elephantiasis nostras verrucosa. (11213240)
2000
15
Magnetic resonance imaging of elephantiasis neuromatosa. (9921933)
1998
16
Erysipelas and elephantiasis of the scrotum--surgery and drug therapy. (9253127)
1997
17
Lay reporting of elephantiasis of the leg in northern Ghana. (8594671)
1995
18
Potential use of IgG2-ELISA in the diagnosis of chronic elephantiasis and IgG4-ELISA in the follow-up of microfilaraemic patients infected with Brugia malayi. (7999024)
1994
19
Elephantiasis and a curved pew-end in Suffolk, England. (2202108)
1990
20
Unusual gynaecological presentations of donovanosis as pseudo-elephantiasis and carcinoma of the cervix. (2400365)
1990
21
Elephantiasis nostras: an eight-year observation of progressive nonfilarial elephantiasis of the lower extremity. (3058397)
1988
22
Endemic elephantiasis as a paediatric problem in the tropics. (2441655)
1987
23
Endemic elephantiasis: early signs and symptoms, and control. (6628370)
1983
24
Elephantiasis nostras verrucosa of the ears. (7094628)
1982
25
Non-filarial elephantiasis. (6105431)
1980
26
Elephantiasis and complicated varicose veins in a tropical population. (79117)
1978
27
A modification of the standard technique for repair of scrotal elephantiasis: case report. (887669)
1977
28
Reconstruction of scrotal and penile skin in elephantiasis. (327094)
1977
29
The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks. (1006757)
1976
30
Endemic elephantiasis of the lower legs in Rwanda and Burundi. (1014068)
1976
31
The effect of Streptococcus on the persistence of Brugia malayi and on the production of elephantiasis in cats. (1201891)
1975
32
Enormous elephantiasis of the scrotum. (4116739)
1972
33
A reconsideration of the problem of elephantiasis. (4902966)
1969
34
Studies on elephantiasis of the legs in Ethiopia. (5361766)
1969
35
Severe elephantiasis of penis and scrotum. (5931596)
1966
36
FAMILIAL EXOGENOUS OBESITY COMPLICATED BY NONFILARIAL SCROTAL ELEPHANTIASIS: CASE HISTORY. (14255644)
1965
37
TISSUE MAST CELLS IN FILARIAL ELEPHANTIASIS. (14154281)
1964
38
THE RIDDLE OF TROPICAL ELEPHANTIASIS. (14077777)
1963
39
The treatment of Bancroftian elephantiasis and observations on hyaluronidase. (14407875)
1959
40
The surgical treatment of elephantiasis of the scrotum. (13419569)
1957
41
Elephantiasis of the scrotum. (13246787)
1955
42
Elephantiasis of the lower extremity; case report. (13207679)
1954
43
Elephantiasis of the lower limbs; treatment by dermo-fibro-lipectomy followed by free skin grafting. (14891392)
1951
44
SCROTECTOMY FOR SCROTAL ELEPHANTIASIS. (18731402)
1948
45
Elephantiasis, with special reference to non-parasitic forms. (20984943)
1946
46
The History of the Recognition of a New Venereal Disease, Comprising Climatic Bubo, Lymphogranuloma Inguinale, EsthiomA"ne, Chronic Elephantiasis and Ulceration of the Vulva, the Genito-ano-rectal Syndrome, Inflammatory Stricture of the Rectum: President's Address. (19989013)
1932
47
ELEPHANTIASIS NERVORUM. (17866466)
1931
48
NON-FILARIAL ELEPHANTIASIS. (20775919)
1930
49
Elephantiasis Arabum in the South Sea Islands. (20754851)
1894
50
Case of elephantiasis. (20895878)
1847

Genetic Variations for Elephantiasis

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Expression for genes affiliated with Elephantiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Elephantiasis

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Pathways for genes affiliated with Elephantiasis

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Compounds for genes affiliated with Elephantiasis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Elephantiasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ozone449.7ELN, RNASE3
2n-formylmethionyl-leucylphenylalanine449.6RNASE3, NCF2
3theophylline44 28 11 2412.4ELN, RNASE3
4h2o2449.3ELN, RNASE3, NCF2

GO Terms for genes affiliated with Elephantiasis

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Products for genes affiliated with Elephantiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Elephantiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet