MCID: ELP001
MIFTS: 39

Elephantiasis malady

Immune diseases category
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Summaries for Elephantiasis

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CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards based summary: Elephantiasis, also known as elephantiasis nos, is related to onchocerciasis and filarial elephantiasis. An important gene associated with Elephantiasis is RNASE3 (ribonuclease, RNase A family, 3). The drug ivermectin and the compounds ozone and theophylline have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone.

Wikipedia:65 Elephantiasis is a symptom of a variety of diseases, where parts of a person\'s body swell to massive... more...

Aliases & Classifications for Elephantiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT
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Elephantiasis, Aliases & Descriptions:

Name: Elephantiasis 8 10 44 62
 
Elephantiasis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:4976
MeSH34 D004604
NCIt39 C34569

Related Diseases for Elephantiasis

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Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to elephantiasis

Symptoms for Elephantiasis

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Drugs & Therapeutics for Elephantiasis

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Drug clinical trials:

Search ClinicalTrials for Elephantiasis

Search NIH Clinical Center for Elephantiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Elephantiasis

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Anatomical Context for Elephantiasis

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MalaCards organs/tissues related to Elephantiasis:

32
Skin, Lymph node, Bone, Thyroid, Testes, Heart, Breast, Cervix

Animal Models for Elephantiasis or affiliated genes

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Publications for Elephantiasis

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Articles related to Elephantiasis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Photoclinic. Elephantiasis nostras verrucosa secondary to lymphedema praecox. (24979570)
2014
2
Elephantiasis nostras verrucosa. (23150746)
2012
3
Genital elephantiasis due to donovanosis: forgotten but not gone yet ... (23155109)
2012
4
Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. (22487446)
2012
5
Comparative dermatology: elephantiasis nostra in verrucous form comparable to coral. (21987163)
2011
6
Giant scrotal elephantiasis: an idiopathic case. (20378026)
2010
7
Elephantiasis Nostras Verrucosa (ENV): a complication of congestive heart failure and obesity. (20453188)
2010
8
Distribution of filarial elephantiasis and hydrocele in Matara district, Sri Lanka, as reported by local leaders, and an immunological survey in areas with relatively high clinical rates. (18508407)
2008
9
Giant scrotal elephantiasis of inflammatory etiology: a case report. (17543128)
2007
10
Elephantiasis neuromatosa in neurofibromatis type I. MRI findings with review of the literature. (16528208)
2006
11
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
12
Idiopathic scrotal elephantiasis. (15708072)
2005
13
Penile and scrotal elephantiasis caused by indolent Chlamydia trachomatis infection. (12559311)
2003
14
Lymphatic Filariasis (Elephantiasis) Elimination: A public health success and development opportunity. (13129436)
2003
15
Bilateral groove sign with penoscrotal elephantiasis. (12473811)
2002
16
Neurofibromatosis, gigantism, elephantiasis neuromatosa and recurrent massive subperiosteal hematoma: a new case report and review of 7 case reports from the literature. (11383296)
2001
17
Lay reporting of elephantiasis of the leg in northern Ghana. (8594671)
1995
18
History of elephantiasis. (8125703)
1993
19
Elephantiasis nostras. (1563290)
1992
20
Elephantiasis nostras verrucosa: beneficial effect of oral etretinate therapy. (1419764)
1992
21
Endemic non-filarial elephantiasis in Iringa District, Tanzania: a study of 30 patients. (3256993)
1988
22
Treatment of elephantiasis in a community with timorian filariasis. (3992641)
1985
23
Pre-elephantiasic stage of endemic nonfilarial elephantiasis of lower legs: "podoconiosis". (6464174)
1984
24
Prevalence of nonfilarial elephantiasis in selected towns in India. (6672090)
1983
25
Malignant schwannoma in neurofibromatous elephantiasis of the upper extremity. (6807594)
1982
26
Elephantiasis and its relation to filarial immunity. (7147010)
1982
27
Endemic elephantiasis of the lower legs in the United Cameroon Republic. (7245337)
1981
28
The long term effects of repeated diethylcarbamazine administration with special reference to microfilaraemia and elephantiasis. (6118029)
1981
29
Elephantiasis nostras verrucosa. (7356700)
1980
30
Elephantiasis nostras. (7353400)
1980
31
The elemental content of lymphatic tissues of barefooted people in Ethiopia, with reference to endemic elephantiasis of the lower legs. (653784)
1978
32
The relationship between endemic elephantiasis of the lower legs and the local soils and climate. (4439458)
1974
33
Non-filarial elephantiasis in Ethiopia. Analytical study of inorganic material in lymph nodes. (4339966)
1972
34
HISTAMINE CONTENT OF SKIN AFFECTED WITH FILARIAL ELEPHANTIASIS. (14154282)
1964
35
Lymphangiography in filarial lymphoedema and elephantiasis. (13880280)
1961
36
Early Tahitian views on elephantiasis. (13443422)
1957
37
Elephantiasis chirurgica: cause and prevention. (14361994)
1955
38
Notes on elephantiasis and hydrocoele due to Wuchereria bancrofti. (14368667)
1955
39
Elephantiasis nostras; similarity of its clinical symptomatology and pathology with elephantiasis tropica vel filarica. (13241040)
1955
40
Elephantiasis nostras. (13118728)
1954
41
Elephantiasis of the lower extremity; case report. (13207679)
1954
42
Elephantiasis nostras. (14848412)
1951
43
Congenital elephantiasis associated with constriction by anomalous bands. (18894608)
1948
44
Diffuse myxoma of lower extremity with elephantiasis. (21001755)
1946
45
Pseudo-Elephantiasis of the Hands. (19989521)
1933
46
Elephantiasis Treated by Kondoleon's Operation. (19988779)
1932
47
Elephantiasis Associated with Tertiary Syphilis. (19974269)
1910
48
Elephantiasis treated by Lymphangioplasty. (19973368)
1909
49
Two Cases of Elephantiasis graecorum. (19972861)
1908
50
Case of elephantiasis. (20895878)
1847

Variations for Elephantiasis

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Expression for genes affiliated with Elephantiasis

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Expression patterns in normal tissues for genes affiliated with Elephantiasis

Search GEO for disease gene expression data for Elephantiasis.

Pathways for genes affiliated with Elephantiasis

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Compounds for genes affiliated with Elephantiasis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Elephantiasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ozone449.7ELN, RNASE3
2theophylline44 28 24 1112.6ELN, RNASE3
3carbohydrates449.5ELN, RNASE3
4manganese44 2410.5ELN, RNASE3
5hyaluronic acid44 2410.4RNASE3, ELN
6formaldehyde44 2410.2ELN, RNASE3

GO Terms for genes affiliated with Elephantiasis

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Products for genes affiliated with Elephantiasis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Elephantiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet