MCID: EMB002
MIFTS: 34

Embryoma malady

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Embryoma

Aliases & Descriptions for Embryoma:

Name: Embryoma 12 14
Blastoma, Nos 12
Blastoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4766
NCIt 47 C8997
SNOMED-CT 64 86049000
UMLS 69 C0936282

Summaries for Embryoma

Disease Ontology : 12 A carcinosarcoma and embryonal cancer that is located in embryonic tissue and results_in a mass of rapidly growing cells.

MalaCards based summary : Embryoma, also known as blastoma, nos, is related to pulmonary blastoma and vulvar benign neoplasm. An important gene associated with Embryoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Temozolomide and Trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, testis and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and behavior/neurological

Wikipedia : 71 Embryonal tumor is a mass of rapidly growing cells. It is believed that it begins in embryonic (fetal)... more...

Related Diseases for Embryoma

Diseases related to Embryoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 pulmonary blastoma 11.2
2 vulvar benign neoplasm 10.2 DICER1 SYP
3 bone deterioration disease 10.1 DICER1 SYP
4 exudative glomerulonephritis 10.1 DICER1 SYP
5 duodenal obstruction 10.1 DICER1 SYP
6 infiltrating renal pelvis transitional cell carcinoma 10.1 AFP SYP
7 pancreatic agenesis 10.1 NEUROD1 SYP
8 ovarian germ cell teratoma 10.1 AFP SYP
9 kidney disease 10.1 AFP SYP
10 rectum leiomyoma 10.1 AFP SYP
11 adult botryoid rhabdomyosarcoma 10.1 AFP SYP
12 biliary tract neoplasm 10.1 AFP DICER1
13 medullomyoblastoma 10.1 AFP SYP
14 pneumonia 10.1 AFP DICER1
15 testicular trophoblastic tumor 10.0 AFP SYP
16 arthus reaction 10.0 AFP SYP
17 urinary tract papillary transitional cell benign neoplasm 10.0 NEUROD1 SYP
18 struma ovarii 10.0 AFP SYP
19 cavernous hemangioma of face 10.0 CTNNB1 SYP
20 bone benign neoplasm 10.0 CTNNB1 SYP
21 bone marrow cancer 10.0 CTNNB1 SYP
22 strabismus 10.0 CTNNB1 SYP
23 childhood central nervous system primitive neuroectodermal neoplasm 10.0 CTNNB1 SYP
24 diabetes mellitus, noninsulin-dependent, 2 10.0 AFP CTNNB1
25 temporal lobe neoplasm 10.0 CTNNB1 SYP
26 prostate stromal sarcoma 9.9 CTNNB1 SYP
27 atopic dermatitis 9.9 AFP SYP
28 nipple neoplasm 9.9 AFP DICER1 SYP
29 pneumothorax 9.9 AFP DICER1 SYP
30 sex differentiation disease 9.9 AFP DICER1 SYP
31 spindle cell rhabdomyosarcoma 9.9 AFP DICER1 SYP
32 submucosal invasive colon adenocarcinoma 9.9 AFP CTNNB1
33 peeling skin syndrome 9.9 CTNNB1 SYP
34 extragonadal germ cell cancer 9.9 CTNNB1 SYP
35 endocrine organ benign neoplasm 9.9 CTNNB1 SYP
36 blastoma 9.9
37 vestibular gland benign neoplasm 9.8 CTNNB1 SYP
38 facial dermatosis 9.8 AFP CTNNB1
39 malignant ovarian mixed epithelial neoplasm 9.8 AFP CTNNB1
40 malignant pleural solitary fibrous tumor 9.8 AFP CTNNB1 SYP
41 hepatitis 9.7
42 thrombosis 9.7
43 sarcoma 9.7
44 thyroiditis 9.7
45 hemihypertrophy 9.7
46 mixed germ cell tumor 9.7
47 gastroesophageal junction adenocarcinoma 9.7 AFP CTNNB1
48 proliferative glomerulonephritis 9.2 AFP CTNNB1 DICER1 NEUROD1 SERPINB8 SYP

Graphical network of the top 20 diseases related to Embryoma:



Diseases related to Embryoma

Symptoms & Phenotypes for Embryoma

GenomeRNAi Phenotypes related to Embryoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.68 DICER1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.68 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.68 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 SERPINB8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.68 SERPINB8
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.68 SERPINB8
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 DICER1 SERPINB8 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.68 CTNNB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.68 DICER1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.68 SERPINB8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.68 DICER1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.68 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 DICER1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.68 CTNNB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.68 DICER1 CTNNB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.68 CTNNB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 SERPINB8
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.68 CTNNB1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.68 SERPINB8

MGI Mouse Phenotypes related to Embryoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 AFP CTNNB1 DICER1 NEUROD1 SYP

Drugs & Therapeutics for Embryoma

Drugs for Embryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
3 Alkylating Agents Phase 2
4 Antineoplastic Agents, Alkylating Phase 2
5 Antimitotic Agents Phase 2
6 Antineoplastic Agents, Phytogenic Phase 2
7 Ado-trastuzumab emtansine Phase 2
8 Antibodies Phase 2
9 Antibodies, Monoclonal Phase 2
10 Immunoglobulins Phase 2
11 Maytansine Phase 2
12
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
13
Dactinomycin Approved 50-76-0 2019 457193
14
Doxorubicin Approved, Investigational 23214-92-8 31703
15
Ifosfamide Approved 3778-73-2 3690
16
Mechlorethamine Approved 51-75-2 4033
17
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
18
Doxil Approved June 1999 31703
19 Anti-Bacterial Agents
20 Antibiotics, Antitubercular
21 Anti-Infective Agents
22 Antirheumatic Agents
23 Immunosuppressive Agents
24 Isophosphamide mustard
25 Nucleic Acid Synthesis Inhibitors
26 Topoisomerase Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase
1 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma Unknown status NCT00936052 Phase 2
2 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 Review of the Paediatric Pleuropulmonary Blastoma French Series Recruiting NCT03044834
5 International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry Recruiting NCT01464606
6 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
9 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769

Search NIH Clinical Center for Embryoma

Genetic Tests for Embryoma

Anatomical Context for Embryoma

MalaCards organs/tissues related to Embryoma:

39
Kidney, Testis, Lung, Ovary, Salivary Gland, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Embryoma:

18
Embryonic Tissue

Publications for Embryoma

Articles related to Embryoma:

(show all 46)
id Title Authors Year
1
Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. ( 16049999 )
2005
2
Diffuse embryoma with intratubular germ-cell neoplasia. ( 15469489 )
2004
3
Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tumor. ( 9159361 )
1997
4
Diffuse embryoma of the testis. ( 7726152 )
1995
5
Diffuse embryoma of the testis. An immunohistochemical study of two cases. ( 7524298 )
1994
6
Embryoma (sialoblastoma) of salivary glands. ( 1444105 )
1992
7
Embryoma (or embryonal tumor) of the parotid gland: report of two cases. ( 3725707 )
1986
8
Diffuse embryoma of the testis. A distinctive form of mixed germ cell tumor. ( 6195930 )
1983
9
Pulmonary blastoma (embryoma lung). A case report with review of literature. ( 1193668 )
1975
10
Renal embryoma in an adult. ( 4339834 )
1972
11
Metastatic renal embryoma: survival following therapy. ( 4293670 )
1967
12
Pulmonary blastoma (embryoma). Report of two cases. ( 5931363 )
1966
13
EMBRYOMA OF KIDNEY IN NEWBORN INFANT: CASE REPORT. ( 14276199 )
1965
14
Radiologic seminar XV: Embryoma of the kidney (Wilm's tumor). ( 13952914 )
1963
15
Primary hepatic malignancy with particular reference to the embryoma of infancy. ( 14492775 )
1961
16
Treatment of pulmonary metastases from malignant embryoma of the testicle with nitrofurazone ( 13820432 )
1960
17
Embryoma of the kidney (Wilms' tumor). ( 14403711 )
1960
18
Malignant embryoma of the neural crest. ( 13746972 )
1960
19
Renal embryoma. ( 13601962 )
1958
20
Polyembryonic embryoma of the ovary of parthenogenetic origin. ( 13426978 )
1957
21
Embryoma of the urinary bladder. ( 13368293 )
1956
22
Bilateral embryoma of the kidney; patient alive and well three years after treatment. ( 13336329 )
1956
23
Embryoma of the kidney; case report of a fourteen-year cure. ( 13334846 )
1956
24
Embryoma of the urinary bladder. ( 13359346 )
1955
25
Adrenogenital syndrome in a male child due to adrenocortical tumor; report of case with hemihypertrophy and subsequent development of embryoma (Wilms' tumor). ( 12983105 )
1952
26
Embryoma of lungs. ( 13015519 )
1952
27
Embryoma of the kidney (Wilms' tumor); a report on two recoveries. ( 14864825 )
1951
28
The effect of preoperative roentgen-ray therapy on arterial hypertension in embryoma (kidney). ( 15395003 )
1949
29
Embryoma of the kidney with symptoms at birth. ( 15409288 )
1949
30
Embryoma of contralateral kidney 10 years following nephrectomy for Wilms' tumor. ( 18130185 )
1949
31
Embryoma of kidney (Wilms' tumor) in children. ( 18137842 )
1949
32
Hypertension in embryoma; Wilms' tumor. ( 18111427 )
1949
33
Embryoma of the testicle in a 5-year old child. ( 18872800 )
1948
34
Wilms' tumor (embryoma of the kidney). ( 18896881 )
1947
35
Embryoma of the kidney (Wilms' tumor). ( 20987926 )
1946
36
Embryoma of the kidney in the adult. ( 20995867 )
1946
37
Wilms' embryoma: A Clinico-Pathological Study. ( 21032107 )
1938
38
EMBRYOMA OF THE KIDNEY (WILMS' TUMOR). ( 17857280 )
1938
39
Wilms' Tumour, or Renal Embryoma of Infancy. ( 19989690 )
1934
40
EMBRYOMA OF THE TESTIS: Sudden Death from Thrombosis of Pulmonary Veins. ( 20772247 )
1925
41
Simple Ovarian Embryoma with Spread into Contiguous Structures. ( 19984494 )
1925
42
EMBRYOMA IN THE OMENTUM CAUSING SYMPTOMS SUGGESTIVE OF URETERAL CALCULUS. ( 20771984 )
1925
43
EMBRYOMA OF THE KIDNEY. ( 17864886 )
1923
44
SARCOMA OR EMBRYOMA OF THE KIDNEY IN INFANTS. ( 17864795 )
1923
45
Cystic Embryoma of Ovary. ( 19981163 )
1920
46
Thyroid Tissue in an Ovarian Embryoma. ( 19975290 )
1911

Variations for Embryoma

Expression for Embryoma

Search GEO for disease gene expression data for Embryoma.

Pathways for Embryoma

Pathways related to Embryoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.53 NEUROD1 SYP

GO Terms for Embryoma

Biological processes related to Embryoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 8.96 CTNNB1 NEUROD1
2 hindbrain development GO:0030902 8.62 CTNNB1 NEUROD1

Molecular functions related to Embryoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.96 CTNNB1 NEUROD1
2 RNA polymerase II activating transcription factor binding GO:0001102 8.62 CTNNB1 NEUROD1

Sources for Embryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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