MCID: EMB004
MIFTS: 55

Embryonal Carcinoma

Categories: Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Embryonal Carcinoma

MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 12 50 56 14 69
Embryonal Neoplasm 12 69
Embryonal Cancer 12 14
Primary Extragonadal Embryonal Carcinoma 12
Extragonadal Embryonal Carcinoma 69
Carcinoma, Embryonal 42
Carcinoma Embryonal 52
Cancer, Embryonal 69
Cancer Embryonal 52
Embryo Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3308 DOID:688
SNOMED-CT 64 189843003 28047004
Orphanet 56 ORPHA180226
MESH via Orphanet 43 D018236
UMLS via Orphanet 70 C0206659
ICD10 via Orphanet 34 C22.7 C71.9

Summaries for Embryonal Carcinoma

NIH Rare Diseases : 50 embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. it most often develops in young and middle-aged men. it tends to grow rapidly and spread outside the testicle. embryonal carcinomas are classified as nonseminoma germ celltumors. most testicular cancers grow from germ cells, the cells that make sperm. germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. nonseminomas, which are more common, tend to grow more quickly than seminomas. nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types. last updated: 2/1/2012

MalaCards based summary : Embryonal Carcinoma, also known as embryonal neoplasm, is related to ovarian embryonal carcinoma and childhood ovarian embryonal carcinoma. An important gene associated with Embryonal Carcinoma is POU5F1 (POU Class 5 Homeobox 1), and among its related pathways/superpathways are ERK Signaling and Human Embryonic Stem Cell Pluripotency. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and mortality/aging

Disease Ontology : 12 An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Wikipedia : 72 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...

Related Diseases for Embryonal Carcinoma

Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Related Disease Score Top Affiliating Genes
1 ovarian embryonal carcinoma 12.2
2 childhood ovarian embryonal carcinoma 12.1
3 intratubular embryonal carcinoma 12.0
4 central nervous system embryonal carcinoma 11.9
5 germ cell and embryonal cancer 11.9
6 adult central nervous system embryonal carcinoma 11.8
7 non-central nervous system-localized embryonal carcinoma 11.8
8 endodermal sinus tumor 11.7
9 teratocarcinoma 11.6
10 embryonal testis carcinoma 11.5
11 testicular germ cell tumor 11.1
12 childhood embryonal testis carcinoma 11.0
13 pediatric cns embryonal cell carcinoma 10.8
14 polyembryoma 10.7
15 intracranial hypotension 10.7 AFP POU5F1
16 hemihyperplasia, isolated 10.7
17 solar retinopathy 10.6 RARA RARB RARS
18 atypical lipomatous tumor 10.6 AFP POU5F1
19 sella turcica neoplasm 10.6 NES SOX2
20 thoracic outlet syndrome 10.5 AFP POU5F1 SOX2
21 myositis 10.5 AFP TNFRSF8
22 central nervous system disease 10.5 AFP POU5F1 SOX2
23 uremia 10.4 POU5F1 SOX2
24 inner ear cancer 10.4 AFP TNFRSF8
25 ovarian cystic teratoma 10.4 AFP POU5F1 TNFRSF8
26 macular retinal edema 10.4 AFP NES POU5F1 SOX2
27 clear cell squamous cell skin carcinoma 10.3 AFP TNFRSF8
28 epiphora due to excess lacrimation 10.3 GDF3 SOX2
29 malignant sertoli-leydig cell tumor 10.3 NES POU5F1 TNFRSF8
30 partial optic atrophy 10.3 BMP4 GDF3 RARB SOX2
31 neuronitis 10.3
32 brown-vialetto-van laere syndrome 10.3 AFP POU5F1 SOX2 TUBB3
33 malignant syringoma 10.2 AFP POU5F1
34 neurodermatitis 10.1 AFP CRABP1 POU5F1 TDGF1
35 visual cortex disease 10.1 AFP POU5F1 SOX2 TNFRSF8
36 anterolateral myocardial infarction 10.1 AFP POU5F1 SOX2 TNFRSF8
37 spinocerebellar ataxia, autosomal recessive 21 10.1 CRABP1 CRABP2 RARA RARB RARS
38 seminoma 10.0
39 germ cells tumors 10.0
40 teratoma 9.9
41 gonadoblastoma 9.7
42 leukemia 9.7
43 choriocarcinoma 9.7
44 prostatitis 9.7
45 androgen insensitivity 9.6
46 male infertility 9.6
47 infertility 9.6
48 mediastinitis 9.6
49 precocious puberty 9.6
50 hypoxia 9.6

Graphical network of the top 20 diseases related to Embryonal Carcinoma:



Diseases related to Embryonal Carcinoma

Symptoms & Phenotypes for Embryonal Carcinoma

GenomeRNAi Phenotypes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 AFP NDN POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Embryonal Carcinoma:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.27 BMP4 CRABP1 CRABP2 FGF4 GATA4 GDF3
2 cellular MP:0005384 10.26 TUBB3 BMP4 FGF4 GATA4 GDF3 LIF
3 embryo MP:0005380 10.24 GDF3 LIF POU5F1 RARA RARB RARG
4 endocrine/exocrine gland MP:0005379 10.18 AFP BMP4 GATA4 LIF POU5F1 RARA
5 digestive/alimentary MP:0005381 10.11 BMP4 GATA4 LIF POU5F1 RARA RARB
6 integument MP:0010771 10.03 BMP4 GATA4 LIF NDN POU5F1 RARG
7 hearing/vestibular/ear MP:0005377 10 BMP4 CRABP1 CRABP2 RARA RARB RARG
8 nervous system MP:0003631 10 NDN POU5F1 RARA RARB RARG SOX2
9 limbs/digits/tail MP:0005371 9.95 BMP4 CRABP1 CRABP2 FGF4 GATA4 RARA
10 normal MP:0002873 9.93 BMP4 CRABP1 FGF4 GATA4 GDF3 NDN
11 muscle MP:0005369 9.87 BMP4 GATA4 LIF NDN RARA RARB
12 reproductive system MP:0005389 9.65 SOX2 AFP BMP4 FGF4 GATA4 LIF
13 respiratory system MP:0005388 9.32 BMP4 FGF4 GATA4 LIF NDN RARA

Drugs & Therapeutics for Embryonal Carcinoma

Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 298)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 33069-62-4 36314
2
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
6 Albumin-Bound Paclitaxel Phase 4,Phase 2,Phase 3,Phase 1
7 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Antineoplastic Agents, Phytogenic Phase 4,Phase 2,Phase 3,Phase 1
12 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Coagulants Phase 4
15 Fibrin Tissue Adhesive Phase 4
16 Hemostatics Phase 4
17
Bleomycin Approved Phase 2, Phase 3 11056-06-7 5360373
18
Cisplatin Approved Phase 2, Phase 3, Phase 1 15663-27-1 84093 441203 2767
19
Etoposide Approved Phase 2, Phase 3, Phase 1 33419-42-0 36462
20
Lenograstim Approved Phase 2, Phase 3, Phase 1 135968-09-1
21
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
22
Mechlorethamine Approved Phase 3,Phase 1,Phase 2 51-75-2 4033
23
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
24
Octreotide Approved, Investigational Phase 2, Phase 3, Phase 1 83150-76-9 383414 6400441
25
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
26
Sunitinib Approved, Investigational Phase 3,Phase 2,Phase 1 341031-54-7, 557795-19-4 5329102
27
Palivizumab Approved, Investigational Phase 3 188039-54-5
28
Ribavirin Approved Phase 3 36791-04-5 37542
29
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
30
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
31
Captopril Approved Phase 3 62571-86-2 44093
32
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
33
Fluconazole Approved Phase 3 86386-73-4 3365
34
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
35
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
36
Mitotane Approved Phase 3 53-19-0 4211
37
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
38
Peginterferon alfa-2a Approved, Investigational Phase 2, Phase 3 198153-51-4 5360545
39
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
40
Vinblastine Approved Phase 3,Phase 2,Phase 1 865-21-4 13342 241903
41
Axitinib Approved, Investigational Phase 2, Phase 3,Phase 1 319460-85-0 6450551
42
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
43 tannic acid Approved, Nutraceutical Phase 2, Phase 3
44
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538
45
Doxil Approved June 1999 Phase 3,Phase 2 31703
46 Etoposide phosphate Phase 2, Phase 3, Phase 1
47 Topoisomerase Inhibitors Phase 2, Phase 3, Phase 1
48 Alkylating Agents Phase 3,Phase 1,Phase 2
49 Isophosphamide mustard Phase 3,Phase 1,Phase 2
50 Antibodies Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 346)

id Name Status NCT ID Phase Drugs
1 RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine Differentiation Completed NCT01317615 Phase 4 RAD001;Paclitaxel;Carboplatin
2 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4 Fibrin Sealant (Tisseel) used in the Experimental Arm.
3 Stereotactic Body Radiotherapy for Head and Neck Tumors Active, not recruiting NCT01344356 Phase 4
4 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
5 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
6 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
7 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
10 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
11 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
12 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
13 Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor Completed NCT00304070 Phase 3 doxorubicin hydrochloride;cisplatin;mitotane;etoposide
14 A Study of Continued Treatment Among Participants Who Have Responded to Peginterferon Alfa-2a (Pegasys®) or Recombinant Interferon Alfa-2a (Roferon-A®) in Prior Clinical Studies Completed NCT02829775 Phase 2, Phase 3 Pegylated Interferon Alfa-2a;Recombinant Interferon Alfa 2a
15 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
16 Study of Anlotinib in Patients With Medullary Thyroid Carcinoma(ALTER01031) Recruiting NCT02586350 Phase 2, Phase 3 Anlotinib;Placebo
17 Sandostatin LAR and Axitinib vs Pbo in Pnts With Advanced Well-differentiated Non-pancreatic Neuroendocrine Carcinomas Recruiting NCT01744249 Phase 2, Phase 3 Axitinib;Sandostatin LAR;Placebo
18 Radiotherapy or Imiquimod in Complex Lentigo Maligna Recruiting NCT02394132 Phase 3 Imiquimod
19 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy
20 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3 cisplatin;etoposide
21 Octreotide Acetate and Recombinant Interferon Alfa-2b or Bevacizumab in Treating Patients With Metastatic or Locally Advanced, High-Risk Neuroendocrine Tumor Active, not recruiting NCT00569127 Phase 3 Octreotide Acetate
22 Adjuvant Avelumab in Merkel Cell Cancer Not yet recruiting NCT03271372 Phase 3 Avelumab
23 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
24 A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors Terminated NCT00428597 Phase 3 sunitinib malate;Placebo
25 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
26 F16IL2 Plus Paclitaxel in Metastatic Merkel Cell Carcinoma Unknown status NCT02054884 Phase 2 Arm A: F16IL2 in combination with paclitaxel;Arm B: Paclitaxel
27 Bevacizumab Plus Somatostatin Analogue and Metronomic Capecitabine in Patients With Advanced Neuroendocrine Tumors Unknown status NCT01203306 Phase 2 bevacizumab + octreotide LAR + capecitabine
28 Imaging Study in Patients With Cancer of the Head & Neck, Lung, Renal Cell, Brain, Lymphoma and Neuroendocrine Tumours Unknown status NCT00323076 Phase 1, Phase 2 18F-FAZA PET Imaging
29 68-Ga-DOTATATE PET-CT Scan for Diagnosis and Staging of Neuroendocrine Tumors Unknown status NCT01879657 Phase 1, Phase 2 68Ga-DOTATATE PET scan
30 177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms Unknown status NCT01237457 Phase 2 177Lu-DOTATATE
31 Survivin Peptide Vaccination for Patients With Advanced Melanoma, Pancreatic, Colon and Cervical Cancer Unknown status NCT00108875 Phase 1, Phase 2
32 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
33 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
34 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
35 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
36 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
37 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
38 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
39 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
40 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
41 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
42 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
43 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
44 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
45 Study of Gemcitabine, Oxaliplatin, and Paclitaxel in Patients With Refractory Germ Cell Carcinoma Completed NCT00183820 Phase 2 paclitaxel, gemcitabine, and oxaliplatin
46 Multicenter Phase II Study of IMC-A12 in Patients With Thymoma and Thymic Carcinoma Who Have Been Previously Treated With Chemotherapy Completed NCT00965250 Phase 2 IMC-12
47 Sorafenib Phase II Study for Japanese Anaplastic or Medullary Thyroid Carcinoma Patients Completed NCT02114658 Phase 2 Sorafenib (Nexavar,BAY43-9006)
48 Safety and Efficacy of Atiprimod Treatment for Patients With Low to Intermediate Grade Neuroendocrine Carcinoma Completed NCT00388063 Phase 2 Atiprimod
49 Avastin (Bevacizumab) and RAD001 (Everolimus) in Advanced Low or Intermediate Grade Neuroendocrine Carcinoma Completed NCT00607113 Phase 2 Avastin;RAD001
50 RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinoma Completed NCT00113360 Phase 2 RAD001;Octreotide Depot

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

Genetic Tests for Embryonal Carcinoma

Anatomical Context for Embryonal Carcinoma

MalaCards organs/tissues related to Embryonal Carcinoma:

39
Lung, Thyroid, Brain, Kidney, Ovary, Testes, Liver

Publications for Embryonal Carcinoma

Articles related to Embryonal Carcinoma:

(show top 50) (show all 362)
id Title Authors Year
1
Increased expression of prion protein gene is accompanied by demethylation of CpG sites in a mouse embryonal carcinoma cell line, P19C6. ( 28132962 )
2017
2
In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta. ( 28662725 )
2017
3
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
4
Embryonal carcinoma presenting as a calcified solitary testicular mass on ultrasound. ( 28765489 )
2017
5
Whole brain radiotherapy with volumetric-modulated arc therapy for pediatric intracranial embryonic carcinoma prevents permanent alopecia. ( 28042910 )
2017
6
Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. ( 28373885 )
2017
7
MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells. ( 28885616 )
2017
8
2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. ( 28552560 )
2017
9
NANOG gene expression is regulated by the ETS transcription factor ETV4 in human embryonic carcinoma NCCIT cells. ( 28412366 )
2017
10
Endobronchial Embryonal Carcinoma. ( 28323728 )
2017
11
MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. ( 26484393 )
2016
12
Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells. ( 27322683 )
2016
13
Immature Teratoma with Embryonal Carcinoma; a Rare Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl. ( 26870146 )
2016
14
Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma. ( 26453693 )
2016
15
Case report: Malignant germ cell tumour with predominant embryonal carcinoma component in a dysgenetic gonad. ( 27773100 )
2016
16
Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells. ( 27803451 )
2016
17
Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. ( 27247146 )
2016
18
Endobronchial Embryonal Carcinoma. ( 27623424 )
2016
19
SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. ( 27283990 )
2016
20
Production of stable GFP-expressing neural cells from P19 embryonal carcinoma stem cells. ( 28013042 )
2016
21
Testis peritubular myoid cells increase their motility and express matrix-metalloproteinase 9 (MMP-9) after interaction with embryonal carcinoma cells. ( 26711538 )
2016
22
Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. ( 27861613 )
2016
23
Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells. ( 26025920 )
2015
24
CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. ( 26177297 )
2015
25
Pulmonary artery stenosis due to embryonal carcinoma with primary mediastinal location. ( 25754058 )
2015
26
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
27
Embryonal Carcinoma in Cryptorchid Abdominal Testis of an Infant. ( 26137335 )
2015
28
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation. ( 25802994 )
2015
29
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-I^/I'- and retinoic acid receptor-dependent mechanisms. ( 26431381 )
2015
30
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. ( 26102294 )
2015
31
The miR-134 attenuates the expression of transcription factor FOXM1 during pluripotent NT2/D1 embryonal carcinoma cell differentiation. ( 25447206 )
2015
32
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. ( 26226633 )
2015
33
NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3. ( 25729271 )
2015
34
Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells. ( 26509926 )
2015
35
Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1. ( 25756534 )
2015
36
Primary pure and nonsecreting embryonal carcinoma of the anterior third ventricle: a case report. ( 25832366 )
2015
37
Aggressive multimodal therapy may prolong disease-free survival in recurrent primary retroperitoneal embryonal carcinoma. ( 25799960 )
2015
38
Metastatic embryonal carcinoma mimicking locally advanced non-small cell lung cancer. ( 25742895 )
2015
39
The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells. ( 26415227 )
2015
40
Seminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines. ( 24887064 )
2014
41
Transcriptional regulation of OCT4 by the ETS transcription factor ESE-1 in NCCIT human embryonic carcinoma cells. ( 24971534 )
2014
42
Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines. ( 24404135 )
2014
43
microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. ( 24462707 )
2014
44
Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic carcinoma cells. ( 24983502 )
2014
45
Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells. ( 25208472 )
2014
46
AP-1-mediated expression of brain-specific class IVa I^-tubulin in P19 embryonal carcinoma cells. ( 25649943 )
2014
47
Dickkopf-3 alters the morphological response to retinoic acid during neuronal differentiation of human embryonal carcinoma cells. ( 24909558 )
2014
48
miR-27 negatively regulates pluripotency-associated genes in human embryonal carcinoma cells. ( 25369332 )
2014
49
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma. ( 25012595 )
2014
50
Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. ( 23378141 )
2014

Variations for Embryonal Carcinoma

Expression for Embryonal Carcinoma

Search GEO for disease gene expression data for Embryonal Carcinoma.

Pathways for Embryonal Carcinoma

Pathways related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 BMP4 FGF4 LIF RARA RARB RARG
2
Show member pathways
12.35 BMP4 FGF4 GATA4 POU5F1 SOX2 TDGF1
3
Show member pathways
12.28 BMP4 GATA4 GDF3 POU5F1 RARB RARG
4 12.13 AFP BMP4 POU5F1 SOX2 TDGF1
5 11.99 BMP4 LIF POU5F1 SOX2
6 11.89 BMP4 GATA4 LIF NDN RARA
7 11.82 LIF NDN SOX2
8 11.81 BMP4 FGF4 GATA4 TDGF1
9
Show member pathways
11.71 RARA RARB RARG
10 11.71 BMP4 FGF4 NES SOX2
11 11.48 BMP4 GATA4 POU5F1 SOX2
12
Show member pathways
11.42 POU5F1 SOX2 TDGF1
13 11.4 AFP BMP4 FGF4 GATA4 LIF NES
14
Show member pathways
11.37 CRABP1 CRABP2 RARA RARB RARG
15 11.26 RARA RARB RARG
16 11.25 CRABP2 RARA RARB RARG
17 11.1 BMP4 CRABP2 LIF RARG
18 11 CRABP1 CRABP2 RARA RARB RARG
19 10.9 FGF4 POU5F1 SOX2
20
Show member pathways
10.58 BMP4 POU5F1 SOX2

GO Terms for Embryonal Carcinoma

Cellular components related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 AFP CRABP1 CRABP2 GDF3 NDN NES

Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 BMP4 FGF4 LIF RARA RARB RARG
2 regulation of gene expression GO:0010468 9.95 BMP4 FGF4 POU5F1 RARG SOX2
3 negative regulation of cell proliferation GO:0008285 9.87 BMP4 LIF NDN RARA RARB RARG
4 multicellular organism growth GO:0035264 9.85 RARA RARB RARG
5 positive regulation of neuron differentiation GO:0045666 9.85 BMP4 RARA RARB
6 neural tube closure GO:0001843 9.84 BMP4 RARA RARG
7 somatic stem cell population maintenance GO:0035019 9.83 POU5F1 SOX2 TDGF1
8 SMAD protein signal transduction GO:0060395 9.82 AFP BMP4 GDF3
9 ureteric bud development GO:0001657 9.78 BMP4 RARA RARB
10 steroid hormone mediated signaling pathway GO:0043401 9.76 BMP4 RARA RARB RARG
11 endoderm development GO:0007492 9.75 BMP4 GATA4 GDF3
12 outflow tract septum morphogenesis GO:0003148 9.73 BMP4 RARA RARB
13 bone development GO:0060348 9.71 BMP4 RARA RARB RARG
14 negative regulation of chondrocyte differentiation GO:0032331 9.7 BMP4 RARB RARG
15 retinoic acid receptor signaling pathway GO:0048384 9.69 RARA RARB RARG
16 response to vitamin A GO:0033189 9.68 GATA4 RARA
17 face development GO:0060324 9.68 RARA RARG
18 cardiac right ventricle morphogenesis GO:0003215 9.68 BMP4 GATA4
19 endocardial cushion development GO:0003197 9.67 BMP4 GATA4
20 regulation of myelination GO:0031641 9.67 RARA RARB RARG
21 embryonic eye morphogenesis GO:0048048 9.66 RARB RARG
22 positive regulation of programmed cell death GO:0043068 9.66 RARB RARG
23 glomerular visceral epithelial cell development GO:0072015 9.65 BMP4 PODXL
24 embryonic camera-type eye development GO:0031076 9.65 NES RARA RARG
25 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.65 BMP4 FGF4 GATA4 LIF NDN POU5F1
26 epithelium development GO:0060429 9.64 BMP4 RARG
27 cranial suture morphogenesis GO:0060363 9.63 BMP4 FGF4
28 retinal pigment epithelium development GO:0003406 9.63 RARB RARG
29 endodermal cell fate specification GO:0001714 9.62 POU5F1 SOX2
30 chondroblast differentiation GO:0060591 9.62 FGF4 RARA
31 ventricular cardiac muscle cell differentiation GO:0055012 9.61 RARA RARB
32 regulation of cell fate commitment GO:0010453 9.6 BMP4 GDF3
33 trachea cartilage development GO:0060534 9.59 RARA RARG
34 negative regulation of cartilage development GO:0061037 9.54 RARA RARB RARG
35 embryonic hindlimb morphogenesis GO:0035116 9.46 BMP4 FGF4 RARB RARG
36 growth plate cartilage development GO:0003417 9.43 RARA RARB RARG
37 glandular epithelial cell development GO:0002068 8.8 RARA RARB RARG
38 multicellular organism development GO:0007275 10.17 BMP4 CRABP1 FGF4 GDF3 LIF NES
39 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10.13 BMP4 POU5F1 RARA RARB RARG SOX2
40 negative regulation of apoptotic process GO:0043066 10.06 BMP4 FGF4 RARA RARB RARG TDGF1
41 positive regulation of gene expression GO:0010628 10.01 BMP4 FGF4 LIF POU5F1 RARA RARG

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.73 GATA4 RARA RARB RARG
2 sequence-specific DNA binding GO:0043565 9.73 GATA4 POU5F1 RARA RARB RARG SOX2
3 steroid hormone receptor activity GO:0003707 9.5 RARA RARB RARG
4 retinoid X receptor binding GO:0046965 9.48 RARB RARG
5 retinol binding GO:0019841 9.46 CRABP1 CRABP2
6 retinal binding GO:0016918 9.4 CRABP1 CRABP2
7 retinoid binding GO:0005501 9.37 CRABP1 CRABP2
8 growth factor activity GO:0008083 9.35 BMP4 FGF4 GDF3 LIF TDGF1
9 retinoic acid binding GO:0001972 9.33 CRABP1 CRABP2 RARA
10 retinoic acid receptor activity GO:0003708 8.8 RARA RARB RARG

Sources for Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....