MCID: EMB004
MIFTS: 59

Embryonal Carcinoma

Categories: Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Embryonal Carcinoma

MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 12 49 55 14 69
Embryonal Neoplasm 12 69
Embryonal Cancer 12 14
Primary Extragonadal Embryonal Carcinoma 12
Extragonadal Embryonal Carcinoma 69
Carcinoma, Embryonal 41
Carcinoma Embryonal 51
Cancer, Embryonal 69
Cancer Embryonal 51
Embryo Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3308 DOID:688
SNOMED-CT 64 189843003 28047004
Orphanet 55 ORPHA180226
MESH via Orphanet 42 D018236
UMLS via Orphanet 70 C0206659
ICD10 via Orphanet 33 C22.7 C71.9

Summaries for Embryonal Carcinoma

NIH Rare Diseases : 49 Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ celltumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types. Last updated: 2/1/2012

MalaCards based summary : Embryonal Carcinoma, also known as embryonal neoplasm, is related to ovarian embryonal carcinoma and embryonal testis carcinoma. An important gene associated with Embryonal Carcinoma is POU5F1 (POU Class 5 Homeobox 1), and among its related pathways/superpathways are ERK Signaling and Developmental Biology. The drugs Bleomycin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include the ovaries or, ovary and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Wikipedia : 72 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...

Related Diseases for Embryonal Carcinoma

Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 ovarian embryonal carcinoma 33.7 AFP POU5F1 SOX2 TNFRSF8
2 embryonal testis carcinoma 33.6 AFP POU5F1
3 germ cell and embryonal cancer 33.5 AFP POU5F1 SOX2
4 intratubular embryonal carcinoma 33.5 AFP KIT POU5F1 TNFRSF8
5 teratocarcinoma 32.3 CRABP1 FGF4 POU5F1 RARA RARB TDGF1
6 mixed germ cell tumor 30.4 AFP KIT
7 teratoma 30.4 AFP KIT POU5F1 SOX2
8 seminoma 30.4 AFP KIT POU5F1 TNFRSF8
9 malignant teratoma 30.1 AFP POU5F1
10 childhood ovarian embryonal carcinoma 12.2
11 central nervous system embryonal carcinoma 12.1
12 adult central nervous system embryonal carcinoma 12.0
13 non-central nervous system-localized embryonal carcinoma 12.0
14 endodermal sinus tumor 11.8
15 testicular germ cell tumor 11.2
16 childhood embryonal testis carcinoma 11.2
17 childhood teratocarcinoma of the testis 10.9
18 pediatric cns embryonal cell carcinoma 10.9
19 polyembryoma 10.9
20 extragonadal germ cell cancer 10.5 AFP POU5F1
21 hepatic angiomyolipoma 10.5 AFP KIT
22 brain germinoma 10.5 AFP KIT POU5F1
23 malignant germ cell tumor 10.5 AFP FGF4
24 keratomalacia 10.5 RARA RARB RARS
25 central nervous system teratoma 10.4 NES SOX2
26 orbital cyst 10.4 GDF3 SOX2
27 neuronitis 10.4
28 endometrial small cell carcinoma 10.4 AFP KIT
29 ovarian solid teratoma 10.3 AFP TNFRSF8
30 venous hemangioma 10.3 POU5F1 SOX2
31 sternum cancer 10.3 AFP TNFRSF8
32 rete testis adenocarcinoma 10.3 AFP KIT
33 central nervous system germ cell tumor 10.2 AFP NES POU5F1 SOX2
34 microphthalmia 10.2 BMP4 GDF3 RARB SOX2
35 conventional fibrosarcoma 10.2 KIT TNFRSF8
36 testicular infarct 10.2 AFP KIT POU5F1 TNFRSF8
37 malignant leydig cell tumor 10.1 KIT NES POU5F1 TNFRSF8
38 mediastinal cancer 10.1 AFP KIT
39 cell type cancer 10.1 AFP KIT POU5F1 SOX2 TUBB3
40 germ cells tumors 10.1
41 mixed germ cell cancer 10.1 AFP CRABP1 POU5F1 TDGF1
42 acute promyelocytic leukemia 10.0 CRABP1 CRABP2 RARA RARB RARS
43 extragonadal seminoma 10.0 AFP KIT POU5F1 SOX2 TNFRSF8
44 testicular germ cell tumor 1 10.0
45 prostatitis 9.9
46 ewing sarcoma 9.9 KIT NES POU5F1 SOX2 TNFRSF8
47 gonadoblastoma 9.8
48 leukemia 9.8
49 choriocarcinoma 9.8
50 androgen insensitivity syndrome 9.7

Graphical network of the top 20 diseases related to Embryonal Carcinoma:



Diseases related to Embryonal Carcinoma

Symptoms & Phenotypes for Embryonal Carcinoma

GenomeRNAi Phenotypes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 NDN POU5F1 AFP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Embryonal Carcinoma:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 NDN RARB POU5F1 RARG RARA GATA4
2 mortality/aging MP:0010768 10.27 RARB NDN POU5F1 RARG RARA GDF3
3 embryo MP:0005380 10.24 RARB POU5F1 RARG RARA GATA4 BMP4
4 endocrine/exocrine gland MP:0005379 10.18 RARA RARB POU5F1 RARG GATA4 BMP4
5 digestive/alimentary MP:0005381 10.11 RARA RARB POU5F1 RARG GATA4 BMP4
6 hearing/vestibular/ear MP:0005377 10.06 RARB RARG RARA BMP4 CRABP1 CRABP2
7 integument MP:0010771 10.03 RARS KIT NDN POU5F1 RARG GATA4
8 limbs/digits/tail MP:0005371 10.01 RARA RARB GATA4 BMP4 CRABP1 CRABP2
9 nervous system MP:0003631 10 KIT RARA NDN RARB POU5F1 RARG
10 normal MP:0002873 9.97 SOX2 RARB NDN POU5F1 RARG RARA
11 muscle MP:0005369 9.87 RARA KIT NDN RARB GATA4 BMP4
12 reproductive system MP:0005389 9.65 RARA RARB POU5F1 RARG GATA4 BMP4
13 respiratory system MP:0005388 9.32 RARB NDN RARG RARA BMP4 KIT

Drugs & Therapeutics for Embryonal Carcinoma

Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 2, Phase 3 11056-06-7 5360373
2
Cisplatin Approved Phase 2, Phase 3, Phase 1 15663-27-1 2767 441203 84093
3
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 2, Phase 3, Phase 1 135968-09-1
5
Paclitaxel Approved, Vet_approved Phase 2, Phase 3, Phase 1 33069-62-4 36314
6
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
7
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
8
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
9
Captopril Approved Phase 3 62571-86-2 44093
10
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
11
Palivizumab Approved, Investigational Phase 3 188039-54-5
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
14
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
15
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
16
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
17
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
18
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Albumin-Bound Paclitaxel Phase 2, Phase 3, Phase 1
21 Anti-Bacterial Agents Phase 2, Phase 3
22 Antibiotics, Antitubercular Phase 2, Phase 3
23 Antimitotic Agents Phase 2, Phase 3, Phase 1
24 Antineoplastic Agents, Phytogenic Phase 2, Phase 3, Phase 1
25 Etoposide phosphate Phase 2, Phase 3
26 Topoisomerase Inhibitors Phase 2, Phase 3
27 Alkylating Agents Phase 3,Phase 1,Phase 2
28 Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
29 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
30 Anti-Infective Agents Phase 3,Phase 1,Phase 2
31 Antimetabolites Phase 3,Phase 1,Phase 2
32 Antiviral Agents Phase 3,Phase 1,Phase 2
33 Angiotensin-Converting Enzyme Inhibitors Phase 3
34 Antihypertensive Agents Phase 3
35 Antirheumatic Agents Phase 3
36 HIV Protease Inhibitors Phase 3
37
protease inhibitors Phase 3
38 Antibodies Phase 3,Phase 2,Phase 1
39 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
40 Immunoglobulins Phase 3,Phase 2,Phase 1
41 Antifungal Agents Phase 3
42 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
43 Cytochrome P-450 CYP3A Inhibitors Phase 3
44 Cytochrome P-450 Enzyme Inhibitors Phase 3
45 Hormone Antagonists Phase 3,Phase 1,Phase 2
46 Hormones Phase 3,Phase 1,Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
48 Hydroxyitraconazole Phase 3
49 Steroid Synthesis Inhibitors Phase 3
50 Antiparasitic Agents Phase 3

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
4 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
6 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
15 Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors Completed NCT01851200 Phase 2 Brentuximab Vedotin
16 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
19 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
20 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
21 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
26 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
27 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
28 Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Recruiting NCT02689219 Phase 2 Brentuximab Vedotin
29 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
30 MEN-10755 in Treating Patients With Solid Tumors Completed NCT00003982 Phase 1 sabarubicin
31 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
32 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
33 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
34 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
35 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
36 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045
37 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800
38 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
39 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

Genetic Tests for Embryonal Carcinoma

Anatomical Context for Embryonal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Carcinoma:

18
The Ovaries Or

MalaCards organs/tissues related to Embryonal Carcinoma:

38
Ovary, Testes, Bone, Bone Marrow, Brain, Testis, Liver

Publications for Embryonal Carcinoma

Articles related to Embryonal Carcinoma:

(show top 50) (show all 372)
# Title Authors Year
1
DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells. ( 29372665 )
2018
2
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. ( 29439916 )
2018
3
Clinical Outcome of Retroperitoneal Lymph Node Dissection after Chemotherapy in Patients with Pure Embryonal Carcinoma in the Orchiectomy Specimen. ( 29410311 )
2018
4
The expression of the embryonic gene Cripto-1 is regulated by OCT4 in human embryonal carcinoma NCCIT cells. ( 29223130 )
2018
5
In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta. ( 28662725 )
2017
6
Endobronchial Embryonal Carcinoma. ( 28323728 )
2017
7
Ovarian Embryonal Carcinoma in a Dog. ( 29169625 )
2017
8
2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. ( 28552560 )
2017
9
Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. ( 29236132 )
2017
10
Increased expression of prion protein gene is accompanied by demethylation of CpG sites in a mouse embryonal carcinoma cell line, P19C6. ( 28132962 )
2017
11
Embryonal Carcinoma with Immature Teratoma: A Homeopathic Case Report. ( 29080895 )
2017
12
Whole brain radiotherapy with volumetric-modulated arc therapy for pediatric intracranial embryonic carcinoma prevents permanent alopecia. ( 28042910 )
2017
13
Embryonal carcinoma presenting as a calcified solitary testicular mass on ultrasound. ( 28765489 )
2017
14
Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons. ( 29057906 )
2017
15
MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells. ( 28885616 )
2017
16
A Rare Case of Embryonal Carcinoma in a Patient with Turner Syndrome without Y Chromosomal Material but Mutations in KIT, AKT1, and ZNF358 Demonstrated Using Exome Sequencing. ( 29197878 )
2017
17
Novel variant of OCT4B4 is differentially expressed in human embryonic stem and embryonic carcinoma cells. ( 28633916 )
2017
18
Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. ( 28373885 )
2017
19
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
20
NANOG gene expression is regulated by the ETS transcription factor ETV4 in human embryonic carcinoma NCCIT cells. ( 28412366 )
2017
21
Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells. ( 27803451 )
2016
22
Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. ( 27247146 )
2016
23
SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. ( 27283990 )
2016
24
Case report: Malignant germ cell tumour with predominant embryonal carcinoma component in a dysgenetic gonad. ( 27773100 )
2016
25
Immature Teratoma with Embryonal Carcinoma; a Rare Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl. ( 26870146 )
2016
26
Endobronchial Embryonal Carcinoma. ( 27623424 )
2016
27
Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells. ( 27322683 )
2016
28
Testis peritubular myoid cells increase their motility and express matrix-metalloproteinase 9 (MMP-9) after interaction with embryonal carcinoma cells. ( 26711538 )
2016
29
Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma. ( 26453693 )
2016
30
Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. ( 27861613 )
2016
31
Production of stable GFP-expressing neural cells from P19 embryonal carcinoma stem cells. ( 28013042 )
2016
32
MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. ( 26484393 )
2016
33
The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells. ( 26415227 )
2015
34
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation. ( 25802994 )
2015
35
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. ( 26102294 )
2015
36
CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. ( 26177297 )
2015
37
NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3. ( 25729271 )
2015
38
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. ( 26226633 )
2015
39
Aggressive multimodal therapy may prolong disease-free survival in recurrent primary retroperitoneal embryonal carcinoma. ( 25799960 )
2015
40
The miR-134 attenuates the expression of transcription factor FOXM1 during pluripotent NT2/D1 embryonal carcinoma cell differentiation. ( 25447206 )
2015
41
Embryonal Carcinoma in Cryptorchid Abdominal Testis of an Infant. ( 26137335 )
2015
42
Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells. ( 26509926 )
2015
43
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-I^/I'- and retinoic acid receptor-dependent mechanisms. ( 26431381 )
2015
44
Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1. ( 25756534 )
2015
45
Primary pure and nonsecreting embryonal carcinoma of the anterior third ventricle: a case report. ( 25832366 )
2015
46
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
47
Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells. ( 26025920 )
2015
48
Metastatic embryonal carcinoma mimicking locally advanced non-small cell lung cancer. ( 25742895 )
2015
49
Pulmonary artery stenosis due to embryonal carcinoma with primary mediastinal location. ( 25754058 )
2015
50
Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells. ( 25208472 )
2014

Variations for Embryonal Carcinoma

Expression for Embryonal Carcinoma

Search GEO for disease gene expression data for Embryonal Carcinoma.

Pathways for Embryonal Carcinoma

Pathways related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 BMP4 FGF4 KIT RARA RARB RARG
2
Show member pathways
13.39 FGF4 KIT POU5F1 RARA RARB RARG
3 12.71 BMP4 FGF4 KIT RARA RARB
4
Show member pathways
12.38 BMP4 FGF4 GATA4 POU5F1 SOX2 TDGF1
5
Show member pathways
12.35 BMP4 GATA4 GDF3 POU5F1 RARB RARG
6 12.14 AFP BMP4 POU5F1 SOX2 TDGF1
7 11.96 BMP4 GATA4 NDN RARA
8 11.75 BMP4 FGF4 GATA4 KIT TDGF1
9
Show member pathways
11.71 RARA RARB RARG
10 11.71 BMP4 FGF4 NES SOX2
11
Show member pathways
11.47 CRABP1 CRABP2 RARA RARB RARG
12
Show member pathways
11.43 POU5F1 SOX2 TDGF1
13 11.42 BMP4 FGF4 KIT
14 11.35 AFP BMP4 FGF4 GATA4 NES PODXL
15 11.33 CRABP2 RARA RARB RARG
16 11.28 BMP4 GATA4 KIT POU5F1 SOX2
17 11.24 RARA RARB RARG
18 11 CRABP1 CRABP2 RARA RARB RARG
19 10.9 FGF4 POU5F1 SOX2
20
Show member pathways
10.61 BMP4 POU5F1 SOX2

GO Terms for Embryonal Carcinoma

Cellular components related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 AFP CRABP1 CRABP2 GDF3 KIT NDN

Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 BMP4 FGF4 GATA4 NDN POU5F1 RARA
2 positive regulation of cell migration GO:0030335 9.95 BMP4 KIT PODXL TDGF1
3 regulation of gene expression GO:0010468 9.95 BMP4 FGF4 POU5F1 RARG SOX2
4 positive regulation of cell proliferation GO:0008284 9.95 BMP4 FGF4 KIT RARA RARB RARG
5 male gonad development GO:0008584 9.86 GATA4 KIT RARA
6 positive regulation of neuron differentiation GO:0045666 9.85 BMP4 RARA RARB
7 multicellular organism growth GO:0035264 9.85 RARA RARB RARG
8 neural tube closure GO:0001843 9.85 BMP4 RARA RARG
9 SMAD protein signal transduction GO:0060395 9.82 AFP BMP4 GDF3
10 ureteric bud development GO:0001657 9.78 BMP4 RARA RARB
11 somatic stem cell population maintenance GO:0035019 9.78 KIT POU5F1 SOX2 TDGF1
12 endoderm development GO:0007492 9.75 BMP4 GATA4 GDF3
13 outflow tract septum morphogenesis GO:0003148 9.74 BMP4 RARA RARB
14 steroid hormone mediated signaling pathway GO:0043401 9.73 BMP4 RARA RARB RARG
15 negative regulation of chondrocyte differentiation GO:0032331 9.7 BMP4 RARB RARG
16 response to vitamin A GO:0033189 9.69 GATA4 RARA
17 face development GO:0060324 9.69 RARA RARG
18 retinoic acid receptor signaling pathway GO:0048384 9.69 RARA RARB RARG
19 cardiac right ventricle morphogenesis GO:0003215 9.68 BMP4 GATA4
20 endocardial cushion development GO:0003197 9.68 BMP4 GATA4
21 embryonic eye morphogenesis GO:0048048 9.67 RARB RARG
22 positive regulation of programmed cell death GO:0043068 9.67 RARB RARG
23 regulation of myelination GO:0031641 9.67 RARA RARB RARG
24 bone development GO:0060348 9.67 BMP4 RARA RARB RARG
25 glomerular visceral epithelial cell development GO:0072015 9.65 BMP4 PODXL
26 epithelium development GO:0060429 9.64 BMP4 RARG
27 cranial suture morphogenesis GO:0060363 9.64 BMP4 FGF4
28 lymphoid progenitor cell differentiation GO:0002320 9.63 BMP4 KIT
29 retinal pigment epithelium development GO:0003406 9.63 RARB RARG
30 embryonic camera-type eye development GO:0031076 9.63 NES RARA RARG
31 endodermal cell fate specification GO:0001714 9.62 POU5F1 SOX2
32 chondroblast differentiation GO:0060591 9.62 FGF4 RARA
33 ventricular cardiac muscle cell differentiation GO:0055012 9.61 RARA RARB
34 regulation of cell fate commitment GO:0010453 9.6 BMP4 GDF3
35 trachea cartilage development GO:0060534 9.59 RARA RARG
36 negative regulation of cartilage development GO:0061037 9.43 RARA RARB RARG
37 growth plate cartilage development GO:0003417 9.33 RARA RARB RARG
38 embryonic hindlimb morphogenesis GO:0035116 9.26 BMP4 FGF4 RARB RARG
39 glandular epithelial cell development GO:0002068 8.8 RARA RARB RARG
40 multicellular organism development GO:0007275 10.2 BMP4 CRABP1 FGF4 GDF3 NES POU5F1
41 negative regulation of transcription by RNA polymerase II GO:0000122 10.14 BMP4 POU5F1 RARA RARB RARG SOX2
42 negative regulation of apoptotic process GO:0043066 10.06 BMP4 FGF4 RARA RARB RARG TDGF1
43 negative regulation of cell proliferation GO:0008285 10.03 BMP4 NDN RARA RARB RARG TNFRSF8
44 positive regulation of gene expression GO:0010628 10.01 BMP4 FGF4 KIT POU5F1 RARA RARG

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.71 GATA4 RARA RARB RARG
2 sequence-specific DNA binding GO:0043565 9.63 GATA4 POU5F1 RARA RARB RARG SOX2
3 growth factor activity GO:0008083 9.56 BMP4 FGF4 GDF3 TDGF1
4 steroid hormone receptor activity GO:0003707 9.5 RARA RARB RARG
5 retinoid X receptor binding GO:0046965 9.48 RARB RARG
6 retinol binding GO:0019841 9.46 CRABP1 CRABP2
7 retinal binding GO:0016918 9.43 CRABP1 CRABP2
8 retinoid binding GO:0005501 9.37 CRABP1 CRABP2
9 retinoic acid binding GO:0001972 9.13 CRABP1 CRABP2 RARA
10 retinoic acid receptor activity GO:0003708 8.8 RARA RARB RARG

Sources for Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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58 PubMed
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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