MCID: EMB005
MIFTS: 54

Embryonal Rhabdomyosarcoma

Categories: Rare diseases, Genetic diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Embryonal Rhabdomyosarcoma

MalaCards integrated aliases for Embryonal Rhabdomyosarcoma:

Name: Embryonal Rhabdomyosarcoma 12 49 28 14
Rhabdomyosarcoma, Embryonal 72 41 69
Rhabdomyosarcoma Embryonal 49 51
Botryoid Rhabdomyosarcoma 49 69
Spindle Cell Rhabdomyosarcomas 49
Erms 49

Classifications:



External Ids:

Disease Ontology 12 DOID:3246
MeSH 41 D018233
NCIt 46 C8971
SNOMED-CT 64 14269005 404051002

Summaries for Embryonal Rhabdomyosarcoma

Disease Ontology : 12 A rhabdomyosarcoma wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo; it occurs most often in the head and neck area or in the genital or urinary organs.

MalaCards based summary : Embryonal Rhabdomyosarcoma, also known as rhabdomyosarcoma, embryonal, is related to spindle cell rhabdomyosarcoma and botryoid rhabdomyosarcoma. An important gene associated with Embryonal Rhabdomyosarcoma is PAX3 (Paired Box 3), and among its related pathways/superpathways are Pathways in cancer and Wnt / Hedgehog / Notch. The drugs Cyclophosphamide and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, prostate and cervix, and related phenotypes are behavior/neurological and cellular

Wikipedia : 72 Sarcoma botryoides or botryoid sarcoma or botryoid rhabdomyosarcoma is a subtype of embryonal... more...

Related Diseases for Embryonal Rhabdomyosarcoma

Diseases in the Embryonal Rhabdomyosarcoma family:

Rhabdomyosarcoma, Embryonal, 2 Rhabdomyosarcoma, Embryonal, 1

Diseases related to Embryonal Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 spindle cell rhabdomyosarcoma 32.6 DES MB MYOD1
2 botryoid rhabdomyosarcoma 31.5 DES DICER1 FOXO1 MB MYOD1 MYOG
3 ectomesenchymoma 30.7 DES PAX3
4 cervical polyp 30.5 DES MYOD1
5 cystic nephroma 30.3 DES DICER1
6 pleuropulmonary blastoma 30.2 DICER1 MB
7 soft tissue sarcoma 30.1 EWSR1 FOXO1
8 blastoma 29.8 DICER1 IGF2
9 embryonal sarcoma 29.4 CDK4 DES MYOD1 MYOG
10 medullomyoblastoma 29.1 DES MB MYCN MYOD1 MYOG
11 leiomyosarcoma 29.1 CDK4 DES IGF2 MB MYOG
12 rhabdomyosarcoma 2 28.0 CDK4 DES FOXO1 MB MYCN MYOD1
13 rhabdomyosarcoma 26.6 CDK4 DES DICER1 EWSR1 FOXO1 GLI1
14 parameningeal embryonal rhabdomyosarcoma 12.4
15 prostate embryonal rhabdomyosarcoma 12.3
16 orbit embryonal rhabdomyosarcoma 12.3
17 vulvar childhood botryoid-type embryonal rhabdomyosarcoma 12.1
18 rhabdomyosarcoma, embryonal, 1 11.2
19 embryonal extrahepatic bile duct rhabdomyosarcoma 11.1
20 mixed type rhabdomyosarcoma 11.1
21 childhood botryoid rhabdomyosarcoma 11.1
22 childhood vagina botryoid rhabdomyosarcoma 11.1
23 giant cell myocarditis 10.5 DES MB
24 myofibroma 10.5 DES MB
25 pulmonary blastoma 10.5 DES DICER1
26 orbit rhabdomyosarcoma 10.5 MB MYOG
27 prostatitis 10.4
28 adenosarcoma 10.4 DES MB
29 horner's syndrome 10.4 DES MYOD1
30 sarcoma 10.4
31 pseudosarcomatous fibromatosis 10.4 DES MYOG
32 meninges sarcoma 10.3 IGF2 MB
33 infantile myofibromatosis 10.3 DES MB
34 ischemic fasciitis 10.3 CDK4 DES
35 mixed liposarcoma 10.3 CDK4 MB
36 malignant triton tumor 10.3 DES MB MYOD1
37 mesenchymoma 10.3 DES MB MYOD1
38 childhood kidney cell carcinoma 10.3 FOXO1 PAX3
39 dedifferentiated liposarcoma 10.2 CDK4 DES
40 alveolar soft part sarcoma 10.2 DES MB MYOD1
41 biphasic synovial sarcoma 10.2 DES EWSR1
42 gallbladder sarcoma 10.2 DES MYOD1 MYOG
43 orbital cancer 10.2 EWSR1 MB
44 mycobacterium abscessus 10.2
45 kidney rhabdoid cancer 10.2 EWSR1 MB
46 adult fibrosarcoma 10.2 MB MYOD1 MYOG
47 cervicitis 10.2
48 bilateral retinoblastoma 10.2 DES MB MYCN
49 conventional leiomyosarcoma 10.2 MYOD1 MYOG PAX7
50 extraskeletal ewing sarcoma 10.2 DES EWSR1

Graphical network of the top 20 diseases related to Embryonal Rhabdomyosarcoma:



Diseases related to Embryonal Rhabdomyosarcoma

Symptoms & Phenotypes for Embryonal Rhabdomyosarcoma

MGI Mouse Phenotypes related to Embryonal Rhabdomyosarcoma:

43 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.35 DES FOXO1 DICER1 CDK4 GLI1 IGF2
2 cellular MP:0005384 10.34 DES FOXO1 DICER1 CDK4 GLI1 MB
3 growth/size/body region MP:0005378 10.34 FOXO1 DICER1 CDK4 GLI1 MB IGF2
4 embryo MP:0005380 10.32 FOXO1 DICER1 CDK4 MB IGF2 GLI1
5 cardiovascular system MP:0005385 10.3 DES DICER1 CDK4 MB FOXO1 IGF2
6 mortality/aging MP:0010768 10.29 DES FOXO1 DICER1 CDK4 GLI1 MB
7 homeostasis/metabolism MP:0005376 10.28 DES DICER1 CDK4 MB FOXO1 IGF2
8 muscle MP:0005369 10.23 FOXO1 DES DICER1 CDK4 MB IGF2
9 hematopoietic system MP:0005397 10.2 DICER1 CDK4 IGF2 MB FOXO1 MYCN
10 craniofacial MP:0005382 10.19 FOXO1 DICER1 GLI1 IGF2 MYCN PAX3
11 digestive/alimentary MP:0005381 10.19 CDK4 GLI1 FOXO1 IGF2 PAX3 MYCN
12 endocrine/exocrine gland MP:0005379 10.17 DICER1 CDK4 IGF2 GLI1 FOXO1 PAX3
13 no phenotypic analysis MP:0003012 10.1 FOXO1 DICER1 IGF2 GLI1 MYCN MYOG
14 integument MP:0010771 10.07 DICER1 CDK4 IGF2 FOXO1 MYOG PAX3
15 normal MP:0002873 10.07 FOXO1 DICER1 CDK4 GLI1 MYCN MYOG
16 limbs/digits/tail MP:0005371 10.05 DICER1 GLI1 FOXO1 IGF2 PAX3 MYCN
17 neoplasm MP:0002006 10.03 FOXO1 DICER1 CDK4 GLI1 PAX3 MYOD1
18 liver/biliary system MP:0005370 9.97 DICER1 CDK4 IGF2 FOXO1 MYCN PAX3
19 renal/urinary system MP:0005367 9.87 DICER1 CDK4 GLI1 IGF2 MYCN PAX3
20 reproductive system MP:0005389 9.86 CDK4 DICER1 GLI1 FOXO1 IGF2 MYOD1
21 respiratory system MP:0005388 9.85 DICER1 MB IGF2 GLI1 MYCN MYOG
22 skeleton MP:0005390 9.61 DICER1 FOXO1 IGF2 PAX3 MYOD1 MYOG
23 vision/eye MP:0005391 9.17 DICER1 CDK4 IGF2 MYCN PAX3 PTCH1

Drugs & Therapeutics for Embryonal Rhabdomyosarcoma

Drugs for Embryonal Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
2
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
3
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
4
Irinotecan Approved, Investigational Phase 3,Phase 2 97682-44-5, 100286-90-6 60838
5
Morphine Approved, Investigational Phase 3,Phase 1,Phase 2 57-27-2 5288826
6
Everolimus Approved Phase 3 159351-69-6 6442177
7
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 6436030 5284616
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Camptothecin Experimental Phase 3,Phase 2 7689-03-4
10 Alkylating Agents Phase 3,Phase 2
11 Anti-Bacterial Agents Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 3,Phase 2
13 Anti-Infective Agents Phase 3,Phase 2
14 Antimitotic Agents Phase 3,Phase 2
15 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
16 Antirheumatic Agents Phase 3,Phase 2
17 Immunosuppressive Agents Phase 3,Phase 2
18 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
19 topoisomerase I inhibitors Phase 3,Phase 2
20 Topoisomerase Inhibitors Phase 3,Phase 2
21 Antifungal Agents Phase 3
22
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
23
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
24
Etoposide Approved Phase 2 33419-42-0 36462
25
Ifosfamide Approved Phase 2 3778-73-2 3690
26
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
27
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
28
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
29
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
30
Doxil Approved June 1999 Phase 2 31703
31 Antibodies Phase 2,Phase 1
32 Antibodies, Monoclonal Phase 2,Phase 1
33 Dermatologic Agents Phase 2
34 Etoposide phosphate Phase 2
35 Immunoglobulins Phase 2,Phase 1
36 Isophosphamide mustard Phase 2 0
37 Keratolytic Agents Phase 2
38 Podophyllotoxin Phase 2 518-28-5
39 Imatinib Mesylate Phase 2 123596
40 Protein Kinase Inhibitors Phase 2,Phase 1
41 insulin Phase 1, Phase 2
42 Insulin, Globin Zinc Phase 1, Phase 2
43 Mitogens Phase 1, Phase 2
44 Keyhole-limpet hemocyanin Phase 1, Phase 2
45 Vaccines Phase 1, Phase 2
46
Formaldehyde Approved, Vet_approved 50-00-0 712

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00354835 Phase 3 Irinotecan Hydrochloride;Cyclophosphamide;Vincristine Sulfate
2 Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma Recruiting NCT02567435 Phase 3 Cyclophosphamide;Irinotecan Hydrochloride;Temsirolimus;Vincristine Sulfate
3 Vincristine, Dactinomycin, and Cyclophosphamide in Treating Patients With Embryonal Rhabdomyosarcoma Unknown status NCT00245089 Phase 2 cyclophosphamide;vincristine sulfate
4 Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Embryonal Rhabdomyosarcoma Unknown status NCT00245141 Phase 2 cyclophosphamide;vincristine sulfate
5 Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma Completed NCT01055314 Phase 2 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Irinotecan Hydrochloride;Temozolomide;Vincristine Sulfate Liposome
6 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
7 Insulin-like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination With the Src Family Kinase (SFK) Inhibitor Dasatinib in People With Embryonal and Alveolar Rhabdomyosarcoma Recruiting NCT03041701 Phase 1, Phase 2 Dasatinib;Ganitumab
8 Therapy to Treat Ewing's Sarcoma, Rhabdomyosarcoma or Neuroblastoma Active, not recruiting NCT00923351 Phase 1, Phase 2 Tumor Purged/CD25 Depleted Lymphocytes;rhIL-7
9 Studying Mechanisms of Radiation Therapy Resistance in Samples From Younger Patients With Rhabdomyosarcoma Completed NCT01626170
10 Biomarkers in Patients With Advanced Rhabdomyosarcoma Completed NCT01668095
11 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
12 Genetic Mutational Analysis of Saliva or Buccal Mucosa Samples From Patients With Embryonal or Alveolar Rhabdomyosarcoma Recruiting NCT03296371
13 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
14 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Embryonal Rhabdomyosarcoma

Cochrane evidence based reviews: rhabdomyosarcoma, embryonal

Genetic Tests for Embryonal Rhabdomyosarcoma

Genetic tests related to Embryonal Rhabdomyosarcoma:

# Genetic test Affiliating Genes
1 Embryonal Rhabdomyosarcoma 28

Anatomical Context for Embryonal Rhabdomyosarcoma

MalaCards organs/tissues related to Embryonal Rhabdomyosarcoma:

38
Skeletal Muscle, Prostate, Cervix, Bone, Liver, Lung, Tongue

Publications for Embryonal Rhabdomyosarcoma

Articles related to Embryonal Rhabdomyosarcoma:

(show top 50) (show all 498)
# Title Authors Year
1
Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations. ( 29230040 )
2018
2
Congenital embryonal rhabdomyosarcoma; multiple lesions. ( 28103501 )
2017
3
When Chemotherapy Is Not Enough-Management of Prostatic Embryonal Rhabdomyosarcoma in an Infant. ( 29155187 )
2017
4
Mandibular embryonal rhabdomyosarcoma with cartilaginous metaplasia: report of a case and review of literature. ( 29029988 )
2017
5
A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition. ( 28194276 )
2017
6
Clinicopathological analysis of concomitant hepatic embryonal rhabdomyosarcoma and hepatocellular carcinoma. ( 28554759 )
2017
7
Embryonal Rhabdomyosarcoma of the Cervix: A Rare Disease at an Uncommon Age. ( 29375950 )
2017
8
Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells. ( 28985758 )
2017
9
Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient. ( 28421158 )
2017
10
NELL1, whose high expression correlates with negative outcomes, has different methylation patterns in alveolar and embryonal rhabdomyosarcoma. ( 28380437 )
2017
11
Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma. ( 28524158 )
2017
12
The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. ( 28614716 )
2017
13
The prognostic value of early radiographic response in children and adolescents with embryonal rhabdomyosarcoma stage IV, metastases confined to the lungs: A report from the Cooperative Weichteilsarkom Studiengruppe (CWS). ( 28306214 )
2017
14
Massive Embryonal Rhabdomyosarcoma of the Hand in an Infant With Metastasis at Birth: Management Dilemma. ( 28718313 )
2017
15
A rare case of embryonal rhabdomyosarcoma of the parapharyngeal space. ( 28530261 )
2017
16
Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient: Case report. ( 29291204 )
2017
17
A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. ( 28923841 )
2017
18
Stage 1 embryonal rhabdomyosarcoma of the female genital tract: a retrospective clinical study of nine cases. ( 28173865 )
2017
19
Embryonal rhabdomyosarcoma of the biliary tree: A rare cause of obstructive jaundice in children which can mimic choledochal cysts. ( 29089679 )
2017
20
12-O-tetradecanoylphorbol-13-acetate and EZH2 inhibition: A novel approach for promoting myogenic differentiation in embryonal rhabdomyosarcoma cells. ( 28722764 )
2017
21
45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to 12 weeks of ARST0331 chemotherapy: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. ( 28548706 )
2017
22
Pediatric Anaplastic Embryonal Rhabdomyosarcoma: Targeted Therapy Guided by Genetic Analysis and a Patient-Derived Xenograft Study. ( 29376028 )
2017
23
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population. ( 26897742 )
2016
24
Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma. ( 27589201 )
2016
25
The Hippo effector TAZ (WWTR1) transforms myoblasts and its abundance is associated with reduced survival in embryonal rhabdomyosarcoma. ( 27184927 )
2016
26
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome. ( 27896549 )
2016
27
Embryonal rhabdomyosarcoma of the perineum in an adult: a case report. ( 27998313 )
2016
28
Embryonal Rhabdomyosarcoma of the Cervix in Young Women. ( 27003182 )
2016
29
Embryonal rhabdomyosarcoma of the epididymis presenting as epididymitis: A case report. ( 27073679 )
2016
30
Spindle Cell Variant of Embryonal Rhabdomyosarcoma: A Rare Entity with Diagnostic Challenges. ( 27656457 )
2016
31
Embryonal rhabdomyosarcoma: A rare oral tumor. ( 27721622 )
2016
32
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation. ( 27764816 )
2016
33
Survivin selective inhibitor YM155 promotes cisplatina89induced apoptosis in embryonal rhabdomyosarcoma. ( 26983495 )
2016
34
Embryonal rhabdomyosarcoma in a child exposed to chemotherapy in utero: a mere coincidence? ( 27802874 )
2016
35
Myxoma virus therapy for human embryonal rhabdomyosarcoma in a nude mouse model. ( 27579297 )
2016
36
Embryonal Rhabdomyosarcoma of the Oesophagus in a Young Dog. ( 27865423 )
2016
37
Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient - case report and review of clinicopathological features. ( 27357857 )
2016
38
Fertility-sparing surgery for the management of young women with embryonal rhabdomyosarcoma of the cervix: A case series. ( 27642626 )
2016
39
Primary embryonal rhabdomyosarcoma of the liver. ( 28039349 )
2016
40
c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines. ( 27104757 )
2016
41
Frequent HRAS Mutations in Malignant Ectomesenchymoma: Overlapping Genetic Abnormalities With Embryonal Rhabdomyosarcoma. ( 26872011 )
2016
42
Embryonal Rhabdomyosarcoma of the Oral Cavity. ( 27743320 )
2016
43
Embryonal rhabdomyosarcoma arising from the uterine corpus in a postmenopausal female: a surgical case challenging the genuine diagnosis on a cytology specimen. ( 26755204 )
2016
44
RECENT INSIGHTS INTO NOTCH SIGNALING IN EMBRYONAL RHABDOMYOSARCOMA. ( 26343114 )
2015
45
Metastasis to bilateral breasts from maxillary embryonal rhabdomyosarcoma demonstrated on F-18 FDG PET/CECT. ( 26853388 )
2015
46
Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma. ( 26783483 )
2015
47
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
48
PEComa of the terminal ileum mesentery as a secondary tumour in an adult survivor of embryonal rhabdomyosarcoma. ( 26628881 )
2015
49
A Case of Embryonal Rhabdomyosarcoma Presenting as a Lobulated Protrusion From the UrethralA Meatus at Birth. ( 26166669 )
2015
50
Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. ( 26056800 )
2015

Variations for Embryonal Rhabdomyosarcoma

Cosmic variations for Embryonal Rhabdomyosarcoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM13016 PTPN11 soft tissue,bladder,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 21
2 COSM532 KRAS soft tissue,bladder,rhabdomyosarcoma,embryonal c.38G>A p.G13D 21

Copy number variations for Embryonal Rhabdomyosarcoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 95623 15 78300000 102531392 Amplification Embryonal rhabdomyosarcoma
2 106824 17 1 24000000 Deletion Embryonal rhabdomyosarcoma
3 149787 2 93300000 243199373 Copy number Embryonal rhabdomyosarcoma
4 194807 5 144500000 180915260 Deletion Embryonal rhabdomyosarcoma
5 230851 8 1 45600000 Amplification Embryonal rhabdomyosarcoma

Expression for Embryonal Rhabdomyosarcoma

Search GEO for disease gene expression data for Embryonal Rhabdomyosarcoma.

Pathways for Embryonal Rhabdomyosarcoma

GO Terms for Embryonal Rhabdomyosarcoma

Cellular components related to Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.4 CDK4 DES DICER1 EWSR1 FOXO1 GLI1

Biological processes related to Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.97 EWSR1 FOXO1 GLI1 IGF2 MYCN MYOD1
2 multicellular organism development GO:0007275 9.8 CDK4 GLI1 IGF2 MYOD1 MYOG PAX3
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.7 FOXO1 GLI1 MYCN MYOD1 MYOG PAX3
4 skeletal muscle fiber development GO:0048741 9.58 MYOD1 MYOG
5 positive regulation of muscle cell differentiation GO:0051149 9.58 MYOD1 MYOG
6 regulation of smoothened signaling pathway GO:0008589 9.57 GLI1 PTCH1
7 skeletal muscle tissue regeneration GO:0043403 9.56 MYOG PAX7
8 positive regulation of myoblast differentiation GO:0045663 9.55 MYOD1 MYOG
9 myoblast differentiation GO:0045445 9.54 MYOD1 MYOG
10 skeletal muscle tissue development GO:0007519 9.54 MYOD1 MYOG PAX7
11 positive regulation of myoblast fusion GO:1901741 9.52 MYOD1 MYOG
12 prostate gland development GO:0030850 9.51 GLI1 PTCH1
13 dorsal/ventral neural tube patterning GO:0021904 9.49 PAX7 PTCH1
14 myotube differentiation GO:0014902 9.48 MYOD1 MYOG
15 positive regulation of skeletal muscle fiber development GO:0048743 9.43 MYOD1 MYOG
16 muscle cell fate commitment GO:0042693 9.4 MYOD1 MYOG
17 muscle organ development GO:0007517 9.26 MYOD1 MYOG PAX3 PAX7
18 positive regulation of transcription, DNA-templated GO:0045893 9.17 FOXO1 GLI1 MYCN MYOD1 MYOG PAX3
19 transcription, DNA-templated GO:0006351 10.06 EWSR1 FOXO1 GLI1 MYCN MYOD1 MYOG

Molecular functions related to Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.87 DICER1 FOXO1 GLI1 MYCN MYOD1 MYOG
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.56 GLI1 MYCN MYOD1 MYOG
3 sequence-specific DNA binding GO:0043565 9.55 FOXO1 MYOD1 MYOG PAX3 PAX7
4 DNA binding transcription factor activity GO:0003700 9.43 FOXO1 MYCN MYOD1 MYOG PAX3 PAX7
5 cyclin binding GO:0030332 9.37 CDK4 PTCH1
6 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 8.8 GLI1 MYOD1 MYOG

Sources for Embryonal Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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