ERMS
MCID: EMB005
MIFTS: 48

Embryonal Rhabdomyosarcoma (ERMS) malady

Summaries for Embryonal Rhabdomyosarcoma

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Embryonal rhabdomyosarcoma (ERMS) is a rare histological form of cancer of connective tissue wherein the... more...

MalaCards: Embryonal Rhabdomyosarcoma, also known as rhabdomyosarcoma embryonal, is related to alveolar rhabdomyosarcoma and neurofibromatosis. An important gene associated with Embryonal Rhabdomyosarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Neural Crest Differentiation and Endometrial cancer. The compounds estrogen and paclitaxel have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Embryonal Rhabdomyosarcoma

Sources:
43NIH Rare Diseases, 61UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

embryonal rhabdomyosarcoma 8 43 10
rhabdomyosarcoma embryonal 43 45
botryoid rhabdomyosarcoma 43 61
spindle cell rhabdomyosarcomas 43
rhabdomyosarcoma, embryonal 61
erms 43


External Ids:

Disease Ontology8 DOID:3246
MeSH35 D018233
SNOMED-CT57 404051002, 14269005
NCIt40 C8971

Related Diseases for Embryonal Rhabdomyosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Embryonal Rhabdomyosarcoma family:

rhabdomyosarcoma, embryonal, 2

Diseases related to Embryonal Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1alveolar rhabdomyosarcoma31.1PAX7, PAX3, MYOG, MYOD1, MYCN, DES
2neurofibromatosis30.4HRAS
3wilms tumor30.1DES, MYCN, MYOD1, MYOG, CYR61
4adenocarcinoma30.1MYCN, GLI1, CYR61, EIF4EBP1, HRAS, SLC16A1
5noonan syndrome30.1DES, CYR61, SGCA
6orbit embryonal rhabdomyosarcoma10.8
7botryoid rhabdomyosarcoma10.8
8prostate embryonal rhabdomyosarcoma10.7
9embryonal sarcoma10.7
10breast rhabdomyosarcoma10.4
11vagina botryoid rhabdomyosarcoma10.4
12spindle cell rhabdomyosarcoma10.4
13vulvar childhood botryoid-type embryonal rhabdomyosarcoma10.4
14bile duct rhabdomyosarcoma10.4
15gallbladder rhabdomyosarcoma10.3
16adult vagina botryoid rhabdomyosarcoma10.3
17costello syndrome10.3
18testis rhabdomyosarcoma10.3
19liver rhabdomyosarcoma10.3
20choledochal cyst10.3
21n syndrome10.3
22soft tissue sarcoma10.3
23teratoma10.3
24mycobacterium abscessus10.3
25uterine inversion10.2
26adult botryoid rhabdomyosarcoma10.2
27childhood vagina botryoid rhabdomyosarcoma10.2
28vagina sarcoma10.2
29uterine sarcoma10.2
30vulvovaginal rhabdomyosarcoma10.2
31renal wilms' tumor10.2
32adult pleomorphic rhabdomyosarcoma10.2
33focal segmental glomerulosclerosis10.1
34acute pancreatitis10.1
35dubowitz syndrome10.1
36embryonal extrahepatic bile duct rhabdomyosarcoma10.1
37tuberous sclerosis10.1
38prostatic cyst10.1
39sudden infant death syndrome10.1
40small cell carcinoma10.1
41mixed type rhabdomyosarcoma10.1
42anus rhabdomyosarcoma10.1
43rectum rhabdomyosarcoma10.1
44ectomesenchymoma10.1
45ovary rhabdomyosarcoma10.1
46mediastinum rhabdomyosarcoma10.1
47childhood botryoid rhabdomyosarcoma10.1
48facioscapulohumeral muscular dystrophy10.1
49uterine carcinosarcoma10.1
50bladder sarcoma10.1

Graphical network of the top 20 diseases related to Embryonal Rhabdomyosarcoma:



Diseases related to embryonal rhabdomyosarcoma

Clinical Features for Embryonal Rhabdomyosarcoma

Drugs & Therapeutics for Embryonal Rhabdomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Embryonal Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Embryonal Rhabdomyosarcoma

Search NIH Clinical Center for Embryonal Rhabdomyosarcoma

Search CenterWatch for Embryonal Rhabdomyosarcoma

Genetic Tests for Embryonal Rhabdomyosarcoma

Anatomical Context for Embryonal Rhabdomyosarcoma

Animal Models for Embryonal Rhabdomyosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Embryonal Rhabdomyosarcoma

Sources:
51PubMed
See all sources

Articles related to Embryonal Rhabdomyosarcoma:

(show top 50)    (show all 434)
idTitleAuthorsYear
1
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
2
Embryonal rhabdomyosarcoma of the uterus in a 35-year-old woman: case report and review of the literature. (24020141)
2013
3
Adult case of large sinonasal embryonal rhabdomyosarcoma with intracranial extension. (23599096)
2013
4
Chromosomal and genetic changes produced in tumoral progression of embryonal rhabdomyosarcoma. (23379258)
2013
5
Embryonal rhabdomyosarcoma of the female genital tract: 5 years' experience. (23350353)
2012
6
Primary embryonal rhabdomyosarcoma of the prostate in adults: report of a case and review of the literature. (21427103)
2011
7
Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. (21948088)
2011
8
Embryonal rhabdomyosarcoma of the testis. (21470524)
2011
9
Embryonal rhabdomyosarcoma with metastases confined to the lungs: report from the CWS Study Group. (21370403)
2011
10
Embryonal rhabdomyosarcoma of the uterine cervix in a 47-year-old woman. (21410833)
2011
11
Embryonal rhabdomyosarcoma of the rectum: report of a case and possible treatment option. (19486088)
2010
12
Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. (20019182)
2010
13
Late relapse of botryoid embryonal rhabdomyosarcoma of the vagina in prepubertal age. (19415026)
2009
14
Intranuclear cytoplasmic inclusions--an extremely unusual finding in embryonal rhabdomyosarcoma: Report of a case diagnosed by fine-needle aspiration biopsy. (19530098)
2009
15
Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy. (19361657)
2009
16
Embryonal rhabdomyosarcoma in a young Maine coon cat. (19122064)
2009
17
Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma. (18377424)
2008
18
Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma. (17585318)
2007
19
Myogenin and desmin immunohistochemistry in the assessment of post-chemotherapy genitourinary embryonal rhabdomyosarcoma: prognostic and management implications. (16945640)
2006
20
Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma. (16729016)
2006
21
Teratoma in an adolescent with malignant transformation into embryonal rhabdomyosarcoma: case report. (17023832)
2006
22
Expression and activity of vascular endothelial growth factor and metalloproteinases in alveolar and embryonal rhabdomyosarcoma cell lines. (16077930)
2005
23
Pathologic quiz case: right upper quadrant abdominal mass in a young woman. Primary hepatorenal embryonal rhabdomyosarcoma with differentiation. (15679450)
2005
24
Embryonal rhabdomyosarcoma of lower lip. (15347880)
2004
25
Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (15024701)
2004
26
Embryonal rhabdomyosarcoma of the tongue in old age. (14969826)
2004
27
Different pattern of matrix metalloproteinases expression in alveolar versus embryonal rhabdomyosarcoma. (15547833)
2004
28
Embryonal rhabdomyosarcoma and chromosomal breakage in a newborn infant with possible Dubowitz syndrome. (10797433)
2000
29
Subsequent urethral relapses with extension into the corpora cavernosa of embryonal rhabdomyosarcoma of the prostate. (10332469)
1999
30
Laryngeal embryonal rhabdomyosarcoma in a child: MRI appearance. (9724448)
1998
31
Primary embryonal rhabdomyosarcoma of the breast in an adolescent female: a case report. (9802822)
1998
32
Embryonal rhabdomyosarcoma of foot with expansive growth between metatarsals. (9060106)
1997
33
Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma. (8635876)
1996
34
A new highly polymorphic DNA restriction site marker in the 5' region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhabdomyosarcoma. (7510263)
1994
35
Bronchial embryonal rhabdomyosarcoma--a case report. (7993655)
1994
36
Cytogenetic analysis of an embryonal rhabdomyosarcoma cell line. (1322234)
1992
37
Embryonal rhabdomyosarcoma of the vagina associated with pregnancy; a case report. (2924994)
1989
38
Embryonal rhabdomyosarcoma of the sphenoid sinus. (3171380)
1988
39
Embryonal rhabdomyosarcoma of the mandible. (3471927)
1987
40
Fine-needle aspiration cytology of prostatic embryonal rhabdomyosarcoma: a case report. (3595414)
1987
41
Embryonal rhabdomyosarcoma in ascitic fluid. Immunocytochemical and DNA flow cytometric study. (3530189)
1986
42
Sonographic and computed tomographic features of embryonal rhabdomyosarcoma of the biliary tract. (6390323)
1984
43
The ultrastructure of alveolar and embryonal rhabdomyosarcoma. A correlative light and electron microscopic study of 17 cases. (6541858)
1984
44
Embryonal rhabdomyosarcoma (botryoid type) of the cervix: a case report and review. (7060985)
1982
45
Five-year survival following cystoprostatectomy for embryonal rhabdomyosarcoma of the prostate. (7426999)
1980
46
Embryonal rhabdomyosarcoma of the bladder and prostate in childhood. (1127815)
1975
47
Combined radical surgery, radiation therapy and chemotherapy in infants with vulvovaginal embryonal rhabdomyosarcoma. (4742656)
1973
48
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the biliary tree. Report of five cases and a review of the literature. (5796778)
1969
49
Primary embryonal rhabdomyosarcoma of the penis in 2-year-old child. (5956780)
1966
50
Two case reports of embryonal rhabdomyosarcoma with primary presentation in the ear. (13468873)
1957

Genetic Variations for Embryonal Rhabdomyosarcoma

Expression for genes affiliated with Embryonal Rhabdomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Embryonal Rhabdomyosarcoma

Search GEO for disease gene expression data for Embryonal Rhabdomyosarcoma.

Pathways for genes affiliated with Embryonal Rhabdomyosarcoma

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Embryonal Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PAX7, PAX3, SNAI1
2
Hide members
10.3KIT, HRAS, EIF4EBP1
310.3FOXO1, EIF4EBP1, HRAS
4
Hide members
10.3FOXO1, EIF4EBP1, HRAS
510.3KIT, HRAS, GLI1, FOXO1
610.2PAX7, PAX3, MYCN, FOXO1

Compounds for genes affiliated with Embryonal Rhabdomyosarcoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Embryonal Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7MYOG, MYOD1
2paclitaxel45 50 1112.5HRAS, EIF4EBP1
3bromodeoxyuridine4510.5DES, MYCN, MYOD1, MYOG, HRAS
4pd 98,0594510.5MYOG, GLI1, EIF4EBP1, HRAS, KIT
5rapamycin4510.5FOXO1, MYOG, EIF4EBP1, HRAS, KIT
6paraffin4510.5DES, MYCN, MYOD1, MYOG, HRAS, KIT
712-o-tetradecanoylphorbol 13-acetate4510.5DES, MYOD1, MYOG, EIF4EBP1, HRAS
8gp 1304510.5KIT, HRAS, MYOD1
9everolimus50 45 1112.5EIF4EBP1, KIT
10lactate4510.5DES, MYCN, KIT, SLC16A4, SLC16A1
11actinomycin d4510.4DES, MYCN, MYOD1, CYR61, EIF4EBP1, KIT
12steroid4510.4DES, MYOD1, MYOG, CYR61, HRAS
13phenylacetate4510.4MYCN, HRAS
14fatty acid4510.4FOXO1, DES, MYOD1, MYOG, SLC16A1
15glucose4510.4SLC16A1, FOXO1, MYOG, GLI1, EIF4EBP1, HRAS
16nitric oxide45 11 2412.4DES, MYCN, MYOG, EIF4EBP1, HRAS, KIT
17leucine4510.4MYCN, MYOD1, EIF4EBP1, HRAS, KIT
18progesterone45 60 29 11 2414.4FOXO1, DES, CYR61, HRAS, KIT
19toluidine4510.4KIT, DES
20oligonucleotide4510.4MYCN, MYOD1, MYOG, CYR61, HRAS, KIT
21phosphatidylinositol4510.4FOXO1, MYOD1, GLI1, CYR61, EIF4EBP1, HRAS
22threonine4510.3FOXO1, DES, MYOD1, EIF4EBP1, HRAS, KIT
23retinoic acid45 2411.3DES, MYCN, MYOD1, MYOG, EIF4EBP1, HRAS
24cysteine4510.3DES, MYOD1, MYOG, CYR61, HRAS, KIT
25testosterone45 60 11 2413.3FOXO1, DES, MYOD1, MYOG, KIT
26vegf4510.3FOXO1, DES, MYCN, MYOD1, MYOG, CYR61
27serine4510.2FOXO1, DES, MYCN, MYOD1, MYOG, EIF4EBP1
28glycogen45 2411.2KIT, EIF4EBP1, DES, FOXO1
29tyrosine4510.1FOXO1, DES, MYCN, MYOD1, MYOG, CYR61
30ly2940024510.1FOXO1, MYOG, EIF4EBP1, HRAS
31doxorubicin45 50 1112.0DES, MYCN, HRAS, KIT

GO Terms for genes affiliated with Embryonal Rhabdomyosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Embryonal Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.8PAX7, SNAI1, MYCN, MYOD1, MYOG, GLI1

Biological processes related to Embryonal Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1monocarboxylic acid transportGO:01571810.5SLC16A4, SLC16A1
2muscle cell fate commitmentGO:04269310.5MYOG, MYOD1
3osteoblast differentiationGO:00164910.5CYR61, GLI1, SNAI1
4positive regulation of cell proliferationGO:00828410.4GLI1, HRAS, KIT, PAX3, TSPAN31
5muscle organ developmentGO:00751710.4PAX3, SGCA, MYOD1
6skeletal muscle fiber developmentGO:04874110.4MYOG, MYOD1
7spinal cord association neuron differentiationGO:02152710.4PAX3, PAX7
8neuron fate commitmentGO:04866310.4PAX7, PAX3
9cellular response to estradiol stimulusGO:07139210.2MYOG, MYOD1
10positive regulation of transcription from RNA polymerase II promoterGO:04594410.2PAX7, FOXO1, MYOD1, MYOG, GLI1, CYR61
11positive regulation of cell migrationGO:03033510.0HRAS, CYR61, SNAI1

Molecular functions related to Embryonal Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.3PAX3, GLI1, MYOD1
2monocarboxylic acid transmembrane transporter activityGO:00802810.0SLC16A1, SLC16A4

Products for genes affiliated with Embryonal Rhabdomyosarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Embryonal Rhabdomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet