MCID: EMB007
MIFTS: 49

Embryonal Sarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Embryonal Sarcoma

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33MalaCards
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MalaCards: Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to sarcoma and rhabdomyosarcoma. An important gene associated with Embryonal Sarcoma is CDK4 (cyclin-dependent kinase 4), and among its related pathways are GADD45 Pathway and Aurora A signaling. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Embryonal Sarcoma

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

embryonal sarcoma 43
undifferentiated sarcoma 62


Related Diseases for Embryonal Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.2DES, MKI67, TP53, VIM, MYOG, S100B
2rhabdomyosarcoma30.3DES, TP53, VIM, MYOD1, MYOG, MDM2
3embryonal rhabdomyosarcoma30.1CDK4, MYOG, MYOD1, DES
4fibrous histiocytoma30.1DES, VIM, S100B
5ovarian cancer30.0MDM2, TP53, CDK4, SLPI
6undifferentiated embryonal sarcoma of the liver11.0
7hepatitis10.6
8prostatitis10.2
9alveolar soft part sarcoma10.1MYOD1
10giant cell glioblastoma10.1MDM2
11dermatofibrosarcoma10.1MDM2
12adenosarcoma10.1DES
13syringoma10.1S100B
14infantile myofibromatosis10.1DES
15fibrous meningioma10.1S100B
16gemistocytic astrocytoma10.1S100B
17juvenile xanthogranuloma10.1S100B
18carney triad10.1KIT
19malignant mesenchymoma10.1MYOD1, MYOG
20choroid plexus papilloma10.1TP53
21gliosarcoma10.1CDK4
22myxoid liposarcoma10.1MDM2, CDK4
23kidney cancer10.1TP53
24anaplastic ependymoma10.1MDM2, S100B
25papilloma10.1TP53
26adenomatoid tumor10.1VIM
27anaplastic oligodendroglioma10.1MDM2, CDK4
28pleomorphic liposarcoma10.1MDM2, KIT
29cutaneous fibrous histiocytoma10.1S100B, DES
30myopathy congenital10.1MYOG, DES
31desmoid tumor10.1KIT, DES
32glomus tumor10.1DES, VIM
33perineurioma10.1VIM, S100B
34clear cell sarcoma10.1S100B, KIT
35epithelioid leiomyosarcoma10.1DES, VIM
36mesenchymal chondrosarcoma10.1DES, VIM
37lipoma10.1CDK4, MDM2, DES
38spindle cell carcinoma10.1DES, VIM
39intraocular melanoma10.1MDM2, CDK4, S100B
40sertoli cell tumor10.1VIM, DES
41myoepithelioma10.1VIM, S100B
42uterine sarcoma10.1DES, MDM2, KIT
43benign meningioma10.1MKI67, MDM2
44malignant mixed mullerian tumor10.1KIT, VIM
45pseudosarcomatous fibromatosis10.1DES, VIM, MYOG
46li-fraumeni syndrome10.1MDM2, TP53
47rhabdoid tumor10.0VIM, DES, MYOD1
48fibroma10.0VIM, DES
49myopathy10.0MYOD1, DES, MYOG
50spindle cell sarcoma10.0DES, VIM, S100B

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to embryonal sarcoma

Symptoms for Embryonal Sarcoma

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Drugs & Therapeutics for Embryonal Sarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Embryonal Sarcoma

Search NIH Clinical Center for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

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Anatomical Context for Embryonal Sarcoma

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33MalaCards
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MalaCards organs/tissues related to Embryonal Sarcoma:

33
Liver, Kidney, Lung, Prostate, Brain, Heart, Smooth muscle, Adrenal gland

Animal Models for Embryonal Sarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Embryonal Sarcoma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4GPC3, MDM2, KIT, TP53
2MP:00053818.9GPC3, MDM2, KIT, TP53, CDK4
3MP:00020068.9MYOD1, CDK4, MDM2, KIT, TP53
4MP:00053678.8CDK4, MDM2, KIT, TP53, GPC3
5MP:00107718.5GPC3, TP53, MYOG, CDK4, MDM2, KIT
6MP:00053908.4GPC3, MDM2, KIT, MYOG, MYOD1, TP53
7MP:00053808.4VIM, MYOG, CDK4, MDM2, KIT, TP53
8MP:00053888.3GPC3, KIT, MYOG, MYOD1, VIM, TP53
9MP:00053898.3VIM, TP53, MYOD1, KIT, MDM2, GPC3
10MP:00030128.1TP53, MALAT1, KIT, MDM2, MYOD1
11MP:00053858.1VIM, TP53, GPC3, DES, MDM2, CDK4
12MP:00053978.1SLPI, CDK4, MDM2, KIT, VIM, GPC3
13MP:00053878.0VIM, TP53, KIT, MDM2, CDK4, SLPI
14MP:00053698.0MYOD1, VIM, TP53, DES, MYOG, KIT
15MP:00028738.0S100B, KIT, MDM2, MYOG, MYOD1, TP53
16MP:00053847.8CDK4, TP53, GPC3, VIM, PEG3, KIT
17MP:00053867.4CDK4, PEG3, DES, VIM, MYOG, S100B
18MP:00053767.2DES, MYOD1, GPC3, TP53, VIM, MYOG
19MP:00053787.1VIM, MYOG, PEG3, GPC3, TP53, MYOD1
20MP:00107686.2MYOD1, VIM, TP53, GPC3, PEG3, DES

Publications for Embryonal Sarcoma

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52PubMed
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Articles related to Embryonal Sarcoma:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
2
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
3
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
4
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
5
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
6
Embryonal sarcoma of the liver in an adult patient. (22690347)
2012
7
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
8
A long-term survival case of adult undifferentiated embryonal sarcoma of liver. (22540346)
2012
9
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
10
Embryonal sarcoma of the liver in an adult mimicking complicated hepatic cyst: MRI findings. (20512902)
2010
11
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
12
A case of embryonal sarcoma of the liver. (21033305)
2010
13
Undifferentiated embryonal sarcoma: a case report. (20207789)
2010
14
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
15
Primary hepatic embryonal sarcoma masquerading as metastatic ovarian cancer. (19549298)
2009
16
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
17
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
18
Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. (17573940)
2007
19
Embryonal sarcoma of liver: an undifferentiated rare primary solid and mucoid to cystic tumour. (18306565)
2007
20
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
21
Pediatric and adult hepatic embryonal sarcoma: a comparative ultrastructural study with morphologic correlations. (17182431)
2006
22
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
23
Mutation of TP53 gene is involved in carcinogenesis of hepatic undifferentiated (embryonal) sarcoma of the adult, in contrast with Wnt or telomerase pathways: an immunohistochemical study of three cases with genomic relation in two cases. (15710230)
2005
24
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
25
Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy. (12673559)
2003
26
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
27
Cystic embryonal sarcoma of the kidney. (12394750)
2002
28
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
29
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
30
Cystic embryonal sarcoma of kidney: a case report. (9635536)
1998
31
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
32
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
33
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
34
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
35
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
36
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
37
Undifferentiated (embryonal) sarcoma arising in conjunction with mesenchymal hamartoma of the liver. (8066077)
1994
38
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
39
Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. (1727675)
1992
40
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
41
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
42
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
43
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
44
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
45
Undifferentiated (embryonal) sarcoma of the liver. (7395519)
1980
46
Embryonal sarcoma of the orbit. A clinical review of 19 Danish cases. (990019)
1976
47
A case of embryonal sarcoma (rhabdomyosarcoma) of the prostate treated with combined surgical and cytostatic therapy. (55104)
1975
48
Pulmonary blastoma (embryonal sarcoma of the lung). (4325327)
1971
49
Embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit. (4284785)
1965
50
Bilateral feline embryonal sarcoma. (13823299)
1960

Variations for Embryonal Sarcoma

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Expression for genes affiliated with Embryonal Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for genes affiliated with Embryonal Sarcoma

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 57SinoBiological, 30KEGG, 54R&D Systems, 60Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDK4, TP53
29.8TP53, MDM2
39.8TP53, MDM2
4
Show member pathways
9.8MDM2, TP53
5
Show member pathways
9.6TP53, MDM2, CDK4
69.6TP53, MDM2, CDK4
7
Show member pathways
Signaling Pathways in Glioblastoma38
9.6TP53, MDM2, CDK4
8
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.6TP53, MDM2, CDK4
99.6TP53, MDM2, CDK4
109.6TP53, MDM2, CDK4
119.6TP53, MDM2, CDK4
12
Show member pathways
Cell cycle38
9.6TP53, MDM2, CDK4
139.6MDM2, CDK4, TP53
149.6CDK4, MDM2, TP53
15
Show member pathways
9.6MDM2, CDK4, TP53
16
Show member pathways
9.6MDM2, TP53, CDK4
17
Show member pathways
9.6MDM2, CDK4, TP53
189.6CDK4, MDM2, TP53
199.6TP53, CDK4, MDM2
209.6MDM2, CDK4, TP53
21
Show member pathways
DNA damage response38
9.6CDK4, TP53, MDM2
229.5TP53, MDM2, GPC3
23
Show member pathways
9.5MYOG, MYOD1
24
Show member pathways
Signal transduction PTEN pathway60
9.5MDM2, TP53, KIT
259.5CDK4, VIM, TP53
269.4VIM, MDM2, TP53
279.2MDM2, CDK4, KIT, TP53
289.2TP53, MDM2, CDK4, KIT
29
Show member pathways
9.2KIT, MDM2, CDK4, TP53
30
Show member pathways
9.2CDK4, MDM2, TP53, MKI67
31
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.2VIM, CDK4, MDM2, TP53
32
Show member pathways
8.6MDM2, CDK4, TP53, KIT, VIM, DES

Compounds for genes affiliated with Embryonal Sarcoma

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1orcein459.9DES, S100B, VIM
2s 100459.8DES, VIM, S100B
3flavopiridol45 1110.5TP53, KIT, MDM2, CDK4
4roscovitine459.5CDK4, VIM, MDM2, TP53
5gefitinib45 51 1111.4KIT, CDK4, MDM2, VIM
6valine459.3CDK4, MDM2, S100B, KIT, VIM
7toluidine459.2VIM, KIT, DES
8thymidylate459.2MDM2, VIM, TP53, MKI67, CDK4
9formaldehyde45 2410.2MKI67, DES, S100B, VIM, KIT
10vincristine45 51 1111.1MDM2, MKI67, TP53, VIM, KIT
11geldanamycin45 51 61 1112.1CDK4, MYOD1, TP53, MDM2, KIT
125fluorouracil459.1MKI67, KIT, MDM2, CDK4, TP53
13irinotecan45 51 1111.0TP53, KIT, MDM2, MKI67
14glycogen45 249.8DES, MKI67, VIM, S100B, KIT, MDM2
15iron45 249.7CDK4, MDM2, DES, SLPI, VIM, S100B
16tgf beta1458.7SLPI, VIM, MYOD1, CDK4, MKI67
17hematoxylin458.7KIT, S100B, VIM, SLPI, MKI67, DES
18estradiol45 24 1110.7DES, SLPI, VIM, MDM2, MKI67, CDK4
19proline458.7VIM, MDM2, MKI67, CDK4, S100B, DES
20doxorubicin45 51 1110.7MDM2, DES, MKI67, TP53, VIM, KIT
21paclitaxel45 51 1110.7MKI67, TP53, VIM, S100B, KIT, MDM2
2212-o-tetradecanoylphorbol 13-acetate458.6DES, CDK4, MYOG, MYOD1, VIM
23methionine458.6KIT, SLPI, S100B, VIM, DES
24ascorbic acid45 249.6SLPI, MKI67, CDK4, MYOG, S100B
25threonine458.5CDK4, DES, MKI67, MYOD1, S100B, KIT
26lactate458.5DES, VIM, S100B, KIT, SLPI, MKI67
27bromodeoxyuridine458.4MYOD1, DES, MKI67, VIM, CDK4, S100B
28progesterone45 29 61 24 1112.4CDK4, KIT, S100B, VIM, TP53, MKI67
29cyclic amp45 249.3DES, VIM, MYOD1, S100B, MDM2, CDK4
30cycloheximide458.3SLPI, MDM2, KIT, MKI67, TP53, CDK4
31butyrate458.2MYOD1, TP53, VIM, CDK4, SLPI, MYOG
325-aza-2deoxycytidine458.2MDM2, PEG3, GPC3, TP53, MYOD1, VIM
33arginine458.2MKI67, MDM2, S100B, MYOD1, VIM, CDK4
34thymidine45 249.2CDK4, DES, MKI67, TP53, S100B, KIT
35creatinine458.2MYOD1, DES, VIM, MYOG, SLPI, S100B
36actinomycin d458.1MYOD1, DES, VIM, SLPI, TP53, MDM2
37nitric oxide45 24 1110.1KIT, S100B, MYOG, MKI67, DES, MDM2
38oxygen45 248.9SLPI, MDM2, S100B, CDK4, MYOG, MYOD1
39glucose457.8MYOD1, MKI67, DES, S100B, KIT, CDK4
40steroid457.6CDK4, SLPI, DES, MDM2, KIT, S100B
41cysteine457.6SLPI, MDM2, DES, VIM, MYOD1, MYOG
42tyrosine457.5DES, S100B, MYOG, KIT, MDM2, CDK4
43paraffin457.5MDM2, KIT, S100B, MYOG, VIM, TP53
44oligonucleotide457.4GPC3, TP53, VIM, MYOD1, MYOG, KIT
45calcium45 51 24 1110.3DES, MYOG, CDK4, MDM2, KIT, S100B
46testosterone45 61 24 1110.2MKI67, VIM, MYOG, S100B, DES, KIT
47retinoic acid45 248.1TP53, MKI67, DES, MYOD1, MYOG, VIM
48estrogen456.8MKI67, TP53, SLPI, CDK4, KIT, S100B
49serine456.8TP53, S100B, SLPI, CDK4, MDM2, KIT
50vegf456.0SLPI, DES, PEG3, CDK4, MDM2, KIT

GO Terms for genes affiliated with Embryonal Sarcoma

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16Gene Ontology
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Cellular components related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.7MDM2, TP53
2transcription factor complexGO:0056679.0MYOD1, MYOG, CDK4
3nucleoplasmGO:0056548.6CDK4, MDM2, MYOG, MYOD1, TP53
4nucleusGO:0056347.1CDK4, MDM2, S100B, MYOG, MYOD1, TP53

Biological processes related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.1MDM2, CDK4
2cellular response to hypoxiaGO:0714569.7MDM2, S100B, TP53
3muscle cell fate commitmentGO:0426939.7MYOG, MYOD1
4positive regulation of cell cycle arrestGO:0711589.6MYOG, TP53
5skeletal muscle fiber developmentGO:0487419.6MYOD1, MYOG
6cellular response to estradiol stimulusGO:0713929.6MYOG, MYOD1
7positive regulation of cell proliferationGO:0082849.6S100B, KIT, MDM2, CDK4
8response to antibioticGO:0466779.5MDM2, TP53
9muscle cell differentiationGO:0426929.5MYOG, MYOD1
10positive regulation of muscle cell differentiationGO:0511499.4MYOD1, MYOG

Molecular functions related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.9MDM2, VIM
2RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0012289.8TP53, MYOG
3chromatin DNA bindingGO:0314909.5MYOD1, MYOG
4ubiquitin protein ligase bindingGO:0316259.4MDM2, MYOD1, TP53
5E-box bindingGO:0708889.4MYOG, MYOD1
6core promoter bindingGO:0010479.2MYOG, MYOD1
7enzyme bindingGO:0198999.2SLPI, MDM2, TP53
8identical protein bindingGO:0428029.1DES, TP53, VIM, S100B, MDM2
9protein bindingGO:0055156.7SLPI, DES, MKI67, GPC3, TP53, VIM

Products for genes affiliated with Embryonal Sarcoma

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  • Antibodies
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  • Antibodies

Sources for Embryonal Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet