MCID: EMB007
MIFTS: 34

Embryonal Sarcoma malady

Cancer diseases category

Summaries for Embryonal Sarcoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to sarcoma and hepatitis. An important gene associated with Embryonal Sarcoma is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and TP53 network. The compounds estrogen and orcein have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Embryonal Sarcoma

About this section
Sources:
42NIH Rare Diseases, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

embryonal sarcoma 42
undifferentiated sarcoma 60


Related Diseases for Embryonal Sarcoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.5VIM, S100B, MDM2, DES, MKI67, MYOD1
2hepatitis30.8GPC3
3embryonal rhabdomyosarcoma30.4DES, MYOD1, MYOG, CDK4
4rhabdomyosarcoma30.4VIM, S100B, MDM2, DES, MYOD1, MYOG
5neuroblastoma30.0TP53
6angiosarcoma30.0VIM, SERPINA3
7pituitary adenoma30.0CDK4, MKI67
8seminoma30.0GPC3, KIT, SLPI
9adenoma30.0MKI67, MYOD1, CDK4, TP53
10chondrosarcoma30.0DES, CDK4, SERPINA3, MDM2, S100B, VIM
11peritonitis30.0SLPI
12hepatoblastoma30.0GPC3
13embryonal cancer29.9MYOD1, MYOG, GPC3, KIT
14fibrous histiocytoma29.9VIM, S100B, DES, SERPINA3
15ovarian cancer29.9TP53, SLPI, CDK4, MDM2
16liver sarcoma11.0
17hepatitis a10.3
18kidney sarcoma10.3
19pleomorphic undifferentiated sarcoma10.3
20cystic kidney10.2
21lung sarcoma10.2
22undifferentiated embryonal sarcoma of the liver10.2
23prostate sarcoma10.1
24prostatitis10.1
25cardiac tamponade10.0
26liver angiosarcoma10.0
27penis sarcoma10.0
28extraskeletal myxoid chondrosarcoma10.0
29bone ewing's sarcoma10.0
30brain ependymoma10.0
31extraosseous ewing's sarcoma10.0
32myxoid chondrosarcoma10.0
33hellp syndrome10.0
34blastoma10.0
35orbit embryonal rhabdomyosarcoma10.0
36prostate embryonal rhabdomyosarcoma10.0
37systemic lupus erythematosus10.0
38liver rhabdomyosarcoma10.0
39brain sarcoma10.0
40appendicitis10.0
41bladder sarcoma10.0
42conjunctivitis10.0
43eosinophilia10.0
44heart sarcoma10.0
45histiocytoma10.0
46liver disease10.0
47lupus erythematosus10.0
48orbit rhabdomyosarcoma10.0
49prostate rhabdomyosarcoma10.0
50pulmonary blastoma10.0

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to embryonal sarcoma

Clinical Features for Embryonal Sarcoma

About this section

Drugs & Therapeutics for Embryonal Sarcoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Embryonal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Embryonal Sarcoma

Search NIH Clinical Center for Embryonal Sarcoma

Search CenterWatch for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

About this section

Anatomical Context for Embryonal Sarcoma

About this section

Animal Models for Embryonal Sarcoma or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Embryonal Sarcoma

About this section

Genetic Variations for Embryonal Sarcoma

About this section

Expression for genes affiliated with Embryonal Sarcoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for genes affiliated with Embryonal Sarcoma

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore, 53Reactome
See all sources

Pathways related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, MDM2
29.8TP53, MDM2
3
Hide members
9.8TP53, MDM2
4
Hide members
9.5MDM2, CDK4, TP53
5
Hide members
9.5TP53, CDK4, MDM2
69.5TP53, CDK4, MDM2
7
Hide members
9.5TP53, CDK4, MDM2
89.5TP53, CDK4, MDM2
9
Transcription P53 signaling pathway
Hide members
9.5MDM2, CDK4, TP53
10
Hide members
9.4AXIN1, KIT, TP53
119.4VIM, CDK4, TP53
12
Hide members
9.2AXIN1, CDK4, MDM2, VIM
139.2TP53, AXIN1, CDK4, MDM2
149.2MDM2, CDK4, KIT, TP53
15
Hide members
9.1TP53, KIT, AXIN1, MDM2
168.9MDM2, CDK4, AXIN1, KIT, TP53
17
Hide members
8.1VIM, MDM2, DES, CDK4, AXIN1, KIT

Compounds for genes affiliated with Embryonal Sarcoma

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1estrogen449.8MYOD1, MYOG
2orcein449.8VIM, DES, S100B
3butyrate449.7MYOD1, MYOG
4s 100449.7DES, S100B, VIM
5paclitaxel44 49 1111.6MDM2, S100B, TP53, CDK4
6vincristine44 49 1111.5KIT, MKI67, VIM
7acetylcholine44 49 28 11 2413.4MYOD1, MYOG, SERPINA3
8toluidine449.4DES, VIM, KIT
9flavopiridol44 1110.3MDM2, CDK4, TP53, KIT
10roscovitine449.3VIM, MDM2, CDK4, TP53
11glucose449.3MYOG, SLPI, SERPINA3
12creatinine449.1MYOD1, SERPINA3, SLPI
13valine449.1CDK4, SERPINA3, VIM, MDM2, S100B, KIT
14thymidylate448.9MDM2, MKI67, CDK4, TP53, VIM
15geldanamycin44 49 59 1111.9KIT, TP53, MYOD1, MDM2, CDK4
16formaldehyde44 249.9DES, S100B, VIM, KIT, MKI67
17methotrexate44 49 1110.8SERPINA3, VIM, MDM2, MKI67, KIT
185fluorouracil448.6MKI67, MDM2, CDK4, TP53, KIT
195-aza-2deoxycytidine448.6GPC3, TP53, MDM2, MYOD1, VIM
20irinotecan44 49 1110.6TP53, MKI67, KIT, MDM2
21glycogen44 249.5KIT, CDK4, MKI67, DES, MDM2, S100B
22serine448.4MYOD1, S100B, SERPINA3, MYOG, MKI67, DES
23methionine448.4SLPI, KIT, DES, S100B, VIM, SERPINA3
24proline448.3TP53, DES, MDM2, S100B, VIM, MKI67
25doxorubicin44 49 1110.3KIT, CDK4, MKI67, DES, MDM2, VIM
26iron44 249.3DES, CDK4, SLPI, MDM2, SERPINA3, S100B
27leucine448.2CDK4, S100B, VIM, MYOD1, SERPINA3, KIT
28hematoxylin448.2MKI67, VIM, SLPI, KIT, DES, S100B
29tgf beta1448.1CDK4, SLPI, VIM, MKI67, MYOD1
30estradiol44 11 2410.0DES, MDM2, VIM, MKI67, CDK4, SLPI
31threonine448.0MKI67, KIT, S100B, MDM2, DES, MYOD1
32bromodeoxyuridine448.0S100B, MKI67, MYOD1, MYOG, CDK4, DES
33lactate447.9SLPI, KIT, MKI67, DES, S100B, VIM
34cyclic amp44 248.8VIM, CDK4, SLPI, MYOD1, DES, MDM2
35progesterone44 59 28 11 2411.8MDM2, VIM, TP53, SERPINA3, KIT, CDK4
36alanine447.6VIM, S100B, MDM2, MYOD1, CDK4, SLPI
37actinomycin d447.6KIT, VIM, MDM2, DES, MYOD1, SLPI
38thymidine44 248.6TP53, MKI67, CDK4, KIT, SLPI, DES
39arginine447.5VIM, MDM2, DES, MKI67, MYOD1, CDK4
40nitric oxide44 11 249.5S100B, SLPI, MDM2, MYOG, DES, CDK4
41calcium44 49 11 2410.3S100B, MYOD1, CDK4, DES, KIT, SERPINA3
42steroid447.3DES, CDK4, MDM2, MKI67, MYOD1, MYOG
43oxygen44 248.0S100B, SERPINA3, MYOD1, SLPI, CDK4, MKI67
44cysteine446.8MYOG, DES, MDM2, CDK4, KIT, SLPI
45tyrosine446.7MYOG, SLPI, KIT, S100B, MDM2, DES
46paraffin446.7SERPINA3, CDK4, KIT, MYOG, DES, MYOD1
47oligonucleotide446.6VIM, KIT, MDM2, MYOD1, MYOG, CDK4
48testosterone44 59 11 249.5MYOD1, MYOG, KIT, SLPI, MKI67, DES
49retinoic acid44 247.1SLPI, SERPINA3, VIM, CDK4, KIT, MYOG
50vegf446.1TP53, SLPI, CDK4, KIT, MYOG, MKI67

GO Terms for genes affiliated with Embryonal Sarcoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.7TP53, MDM2, MKI67, MYOD1, MYOG, CDK4

Biological processes related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:0714569.5TP53, MDM2, S100B
2muscle cell fate commitmentGO:0426939.4MYOG, MYOD1
3skeletal muscle fiber developmentGO:0487419.3MYOG, MYOD1
4positive regulation of cell proliferationGO:0082849.3KIT, CDK4, MDM2, S100B
5cellular response to estradiol stimulusGO:0713929.2MYOD1, MYOG
6positive regulation of cell cycle arrestGO:0711589.2TP53, MYOG

Molecular functions related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.5TP53, AXIN1, MDM2
2RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positiGO:0012289.2TP53, MYOG
3ubiquitin protein ligase bindingGO:0316259.1TP53, AXIN1, MYOD1
4enzyme bindingGO:0198998.5MDM2, AXIN1, SLPI, TP53
5identical protein bindingGO:0428028.5VIM, S100B, MDM2, DES, AXIN1, TP53
6protein bindingGO:0055155.4TP53, VIM, S100B, MDM2, DES, MKI67

Products for genes affiliated with Embryonal Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Embryonal Sarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet