MCID: EMB007
MIFTS: 47

Embryonal Sarcoma

Categories: Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Embryonal Sarcoma

MalaCards integrated aliases for Embryonal Sarcoma:

Name: Embryonal Sarcoma 49
Undifferentiated Sarcoma 69

Classifications:



External Ids:

UMLS 69 C0855073

Summaries for Embryonal Sarcoma

MalaCards based summary : Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to undifferentiated embryonal sarcoma of the liver and fibrous histiocytoma, and has symptoms including fever An important gene associated with Embryonal Sarcoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Endometrial cancer and PI3K-Akt signaling pathway. The drugs Vincristine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and kidney, and related phenotypes are Decreased influenza A/WSN/33 replication and behavior/neurological

Related Diseases for Embryonal Sarcoma

Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 undifferentiated embryonal sarcoma of the liver 32.0 CDK4 MALAT1 MDM2 MYOD1 MYOG PEG3
2 fibrous histiocytoma 29.8 DES SERPINA3 VIM
3 embryonal rhabdomyosarcoma 29.1 CDK4 DES MYOD1 MYOG
4 rhabdomyosarcoma 28.9 CDK4 DES MDM2 MYOD1 MYOG TP53
5 histiocytoma 28.7 CDK4 KIT MDM2 MYOD1 SERPINA3 TP53
6 sarcoma 10.7
7 intravascular papillary endothelial hyperplasia 10.6 SERPINA3 VIM
8 hydromyelia 10.6 S100B VIM
9 bednar tumor 10.6 S100B VIM
10 primary hepatic neuroendocrine carcinoma 10.5 S100B VIM
11 malignant giant cell tumor 10.5 S100B TP53
12 acinar cell cystadenocarcinoma 10.5 MKI67 SERPINA3
13 brain ependymoma 10.5 MKI67 TP53
14 retroperitoneal fibrosis 10.5 MDM2 VIM
15 actinic cheilitis 10.5 MDM2 TP53
16 fibrous meningioma 10.5 S100B VIM
17 chordoid meningioma 10.5 S100B VIM
18 spitz nevus 10.5 MKI67 TP53
19 reticular perineurioma 10.5 KIT S100B
20 mast-cell sarcoma 10.5 KIT VIM
21 eccrine porocarcinoma 10.5 S100B VIM
22 prostate embryonal rhabdomyosarcoma 10.5 KIT MYOD1
23 odontogenic myxoma 10.5 S100B SERPINA3 VIM
24 squamous cell carcinoma of the larynx 10.4 MKI67 TP53
25 spiradenoma 10.4 S100B TP53 VIM
26 cerebral primitive neuroectodermal tumor 10.4 S100B TP53 VIM
27 optic nerve glioma 10.4 S100B TP53 VIM
28 mixed type thymoma 10.4 KIT S100B
29 sclerosing liposarcoma 10.4 MDM2 TP53
30 skin glomus tumor 10.4 DES VIM
31 anaplastic ependymoma 10.4 MDM2 S100B VIM
32 malignant mixed mullerian tumor 10.4 KIT VIM
33 ameloblastic carcinoma 10.4 MKI67 VIM
34 infantile digital fibromatosis 10.4 DES VIM
35 prostate rhabdomyosarcoma 10.4 KIT MYOD1
36 lip cancer 10.4 MDM2 TP53
37 extraosseous ewing's sarcoma 10.4 MYOD1 MYOG S100B
38 sarcomatoid squamous cell skin carcinoma 10.4 KIT TP53
39 endometrial mucinous adenocarcinoma 10.4 MKI67 VIM
40 lymphangiomatosis 10.4 DES VIM
41 angiolipoma 10.4 DES VIM
42 ependymoma 10.4 MKI67 S100B VIM
43 primitive neuroectodermal tumor of the cervix uteri 10.4 DES VIM
44 cellular schwannoma 10.4 MDM2 S100B TP53
45 fallopian tube adenocarcinoma 10.4 MYOG TP53
46 cutaneous leiomyosarcoma 10.4 DES VIM
47 female reproductive endometrioid cancer 10.4 CTNNB1 TP53
48 perineurioma 10.3 KIT S100B VIM
49 parachordoma 10.3 DES VIM
50 chordoid glioma 10.3 S100B TP53

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to Embryonal Sarcoma

Symptoms & Phenotypes for Embryonal Sarcoma

UMLS symptoms related to Embryonal Sarcoma:


fever

GenomeRNAi Phenotypes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A/WSN/33 replication GR00195-A-1 8.92 AXIN1 CTNNB1 MDM2 MYOD1

MGI Mouse Phenotypes related to Embryonal Sarcoma:

43 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 MDM2 KIT CDK4 DES AXIN1 CTNNB1
2 cardiovascular system MP:0005385 10.28 GPC3 MDM2 KIT CDK4 DES AXIN1
3 cellular MP:0005384 10.27 GPC3 MDM2 KIT DES CDK4 AXIN1
4 homeostasis/metabolism MP:0005376 10.26 GPC3 MDM2 KIT CTNNB1 DES CDK4
5 mortality/aging MP:0010768 10.26 GPC3 MDM2 KIT CDK4 DES AXIN1
6 growth/size/body region MP:0005378 10.24 KIT GPC3 MDM2 CTNNB1 CDK4 AXIN1
7 embryo MP:0005380 10.2 MDM2 KIT GPC3 CDK4 AXIN1 CTNNB1
8 integument MP:0010771 10.11 GPC3 MDM2 KIT CDK4 CTNNB1 MYOG
9 muscle MP:0005369 10.11 MDM2 KIT CDK4 DES CTNNB1 VIM
10 digestive/alimentary MP:0005381 10.1 GPC3 MDM2 KIT CDK4 AXIN1 CTNNB1
11 normal MP:0002873 10.07 MDM2 KIT MKI67 MYOD1 CDK4 AXIN1
12 craniofacial MP:0005382 10.04 KIT GPC3 MDM2 CTNNB1 AXIN1 TP53
13 limbs/digits/tail MP:0005371 9.97 KIT GPC3 MDM2 CTNNB1 AXIN1 TP53
14 no phenotypic analysis MP:0003012 9.95 MDM2 KIT MKI67 CTNNB1 MYOG MYOD1
15 neoplasm MP:0002006 9.91 MDM2 KIT CTNNB1 CDK4 TP53 MYOD1
16 reproductive system MP:0005389 9.85 MDM2 KIT CDK4 GPC3 AXIN1 CTNNB1
17 pigmentation MP:0001186 9.8 MDM2 KIT GPC3 CDK4 CTNNB1 TP53
18 renal/urinary system MP:0005367 9.8 GPC3 MDM2 KIT CDK4 AXIN1 CTNNB1
19 respiratory system MP:0005388 9.56 GPC3 KIT AXIN1 CTNNB1 VIM MYOD1
20 skeleton MP:0005390 9.23 KIT GPC3 MDM2 CTNNB1 AXIN1 TP53

Drugs & Therapeutics for Embryonal Sarcoma

Drugs for Embryonal Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Idarubicin Approved Phase 3 58957-92-9 42890
7 Trofosfamide Investigational Phase 3 22089-22-1
8 Alkylating Agents Phase 3,Phase 2
9 Nucleic Acid Synthesis Inhibitors Phase 3
10 Anti-Bacterial Agents Phase 3,Phase 1
11 Anti-Infective Agents Phase 3
12 Immunosuppressive Agents Phase 3,Phase 2
13 Antimitotic Agents Phase 3
14 Antibiotics, Antitubercular Phase 3,Phase 1
15 Antineoplastic Agents, Phytogenic Phase 3
16 Antirheumatic Agents Phase 3,Phase 2
17 Topoisomerase Inhibitors Phase 3,Phase 1
18 Etoposide phosphate Phase 3
19
nivolumab Approved Phase 2 946414-94-4
20
Pembrolizumab Approved Phase 2 1374853-91-4
21 Antibodies, Monoclonal Phase 2
22 Immunoglobulins Phase 2
23 Antibodies Phase 2
24
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
25
Doxil Approved June 1999 Phase 1 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
2 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3 trofosfamide, idarubicin, etoposide
3 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2 Pembrolizumab
4 A Study of Nivolumab in Selected Uterine Cancer Patients Recruiting NCT03241745 Phase 2 Nivolumab
5 Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial Recruiting NCT02406781 Phase 2 Combination of MK3475 with Metronomic CP
6 Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children Not yet recruiting NCT03111069 Phase 1 Doxorubicin
7 Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas Completed NCT01802125

Search NIH Clinical Center for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

Anatomical Context for Embryonal Sarcoma

MalaCards organs/tissues related to Embryonal Sarcoma:

38
Liver, Lung, Kidney, Prostate, Adrenal Gland, Heart, Smooth Muscle

Publications for Embryonal Sarcoma

Articles related to Embryonal Sarcoma:

(show top 50) (show all 154)
# Title Authors Year
1
A case of adult undifferentiated embryonal sarcoma of the liver successfully treated with right trisectionectomy: a case report. ( 28144858 )
2017
2
Unresectable Undifferentiated Embryonal Sarcoma of the Liver in an Adult Male Treated with Chemotherapy and Orthotopic Liver Transplantation. ( 29226049 )
2017
3
Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis. ( 28539230 )
2017
4
Undifferentiated embryonal sarcoma of the liver in an adult patient. ( 27377912 )
2016
5
Adult Embryonal Sarcoma of the Liver: Management of a Massive Liver Tumor. ( 27895954 )
2016
6
Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. ( 27562247 )
2016
7
A Case of Ruptured Adult Embryonal Sarcoma of the Liver with Excellent Outcome After Neoadjuvant Chemotherapy. ( 27714652 )
2016
8
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. ( 26925712 )
2016
9
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database. ( 27781381 )
2016
10
Undifferentiated embryonal sarcoma of the liver in a young female: treatment with portal vein embolization and liver trisectonectomy. ( 27621753 )
2016
11
A single-center experience with undifferentiated embryonal sarcoma of the liver. ( 27427850 )
2016
12
Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature. ( 27034807 )
2016
13
The Role of Liver Transplantation in Undifferentiated Embryonal Sarcoma of the Liver in Children. ( 27438021 )
2016
14
Repeated hepatic resections and radio-frequency ablations may improve the survival of adult undifferentiated embryonal sarcoma of the liver: report of two cases. ( 26366352 )
2015
15
Undifferentiated embryonal sarcoma of the liver: a concise review. ( 25611111 )
2015
16
Pre-operatively misdiagnosed undifferentiated embryonal sarcoma of the liver: analysis of 16 cases. ( 26807408 )
2015
17
Undifferentiated Embryonal Sarcoma of Liver. ( 26788276 )
2015
18
Undifferentiated (embryonal) sarcoma of liver. ( 26312248 )
2015
19
Mesenchymal hamartoma or embryonal sarcoma of the liver in childhood: a difficult diagnosis before complete surgical excision. ( 25148740 )
2014
20
Undifferentiated embryonal sarcoma of liver: a multi-institutional experience with 9 cases. ( 25674229 )
2014
21
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. ( 24762610 )
2014
22
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. ( 25603636 )
2014
23
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. ( 25120683 )
2014
24
A Rare Case of Childhood Undifferentiated Embryonal Sarcoma of the Liver Managed Successfully. ( 26157829 )
2014
25
Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report. ( 25038546 )
2014
26
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. ( 25364566 )
2014
27
Undifferentiated embryonal sarcoma in adult liver. ( 25214865 )
2014
28
Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma. ( 24142883 )
2014
29
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. ( 24054758 )
2013
30
Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature. ( 23426588 )
2013
31
Embryonal sarcoma of the liver. ( 23864278 )
2013
32
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. ( 24073982 )
2013
33
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. ( 24079623 )
2013
34
Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. ( 24120702 )
2013
35
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. ( 24210186 )
2013
36
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. ( 22551002 )
2012
37
An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion. ( 23071865 )
2012
38
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. ( 22421287 )
2012
39
Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver. ( 21937079 )
2012
40
A long-term survival case of adult undifferentiated embryonal sarcoma of liver. ( 22540346 )
2012
41
Embryonal sarcoma of the liver in an adult patient. ( 22690347 )
2012
42
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. ( 25374706 )
2012
43
Undifferentiated embryonal sarcoma of the liver in an adult patient: case report. ( 22798120 )
2012
44
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. ( 22146632 )
2011
45
Undifferentiated embryonal sarcoma of liver in an adult masquerading as complicated hydatid cyst. ( 21301015 )
2011
46
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. ( 20925497 )
2011
47
Embryonal sarcoma of the liver in an adult mimicking complicated hepatic cyst: MRI findings. ( 20512902 )
2010
48
A case of embryonal sarcoma of the liver mimicking a hydatid cyst in an adult. ( 20559529 )
2010
49
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. ( 20105209 )
2010
50
Embryonal sarcoma of the liver with chondroid differentiation. ( 21160625 )
2010

Variations for Embryonal Sarcoma

Expression for Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for Embryonal Sarcoma

Pathways related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 AXIN1 CDK4 CTNNB1 KIT MDM2 TP53
2
Show member pathways
12.76 AXIN1 CDK4 CTNNB1 KIT MDM2 TP53
3
Show member pathways
12.62 AXIN1 CDK4 CTNNB1 KIT TP53
4 12.36 AXIN1 CDK4 CTNNB1 KIT MDM2 TP53
5 12.24 CDK4 MDM2 MKI67 TP53 VIM
6
Show member pathways
12.23 AXIN1 CTNNB1 KIT TP53
7 12.16 CTNNB1 GPC3 MDM2 TP53
8 12.05 AXIN1 CDK4 CTNNB1 TP53 VIM
9 11.92 CDK4 CTNNB1 MDM2 TP53
10 11.89 AXIN1 CTNNB1 MDM2 TP53
11 11.87 CDK4 TP53 VIM
12 11.84 CTNNB1 MDM2 TP53
13 11.71 CDK4 MDM2 TP53
14 11.68 AXIN1 CTNNB1 MDM2 TP53
15 11.63 CTNNB1 MKI67 VIM
16 11.62 CDK4 MDM2 TP53
17
Show member pathways
11.48 CTNNB1 MYOD1 MYOG
18 11.33 CDK4 MDM2 TP53
19 11.3 CDK4 MDM2 TP53
20 11.24 DES KIT MYOD1 MYOG
21 11.09 CDK4 MDM2 TP53
22 11.07 AXIN1 CDK4 CTNNB1 MDM2 TP53
23 10.86 AXIN1 CTNNB1

GO Terms for Embryonal Sarcoma

Cellular components related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 9.56 MDM2 MKI67 MYOD1 TP53
2 beta-catenin destruction complex GO:0030877 9.16 AXIN1 CTNNB1
3 transcription factor complex GO:0005667 9.02 CDK4 CTNNB1 MYOD1 MYOG TP53
4 fascia adherens GO:0005916 8.96 CTNNB1 DES

Biological processes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.89 AXIN1 CTNNB1 MYOD1 MYOG TP53
2 positive regulation of cell proliferation GO:0008284 9.85 CDK4 CTNNB1 KIT MDM2 S100B
3 response to drug GO:0042493 9.81 CDK4 CTNNB1 MDM2 TP53
4 positive regulation of gene expression GO:0010628 9.72 CTNNB1 KIT MDM2 TP53 VIM
5 cellular response to hypoxia GO:0071456 9.7 MDM2 S100B TP53
6 response to hyperoxia GO:0055093 9.58 CDK4 TP53
7 anterior/posterior axis specification GO:0009948 9.57 CTNNB1 GPC3
8 positive regulation of myoblast fusion GO:1901741 9.56 MYOD1 MYOG
9 positive regulation of protein export from nucleus GO:0046827 9.55 MDM2 TP53
10 intermediate filament organization GO:0045109 9.54 DES VIM
11 cellular response to growth factor stimulus GO:0071363 9.54 CTNNB1 MDM2 MYOG
12 myotube differentiation GO:0014902 9.48 MYOD1 MYOG
13 positive regulation of skeletal muscle fiber development GO:0048743 9.43 MYOD1 MYOG
14 positive regulation of cell cycle GO:0045787 9.43 CDK4 MDM2 TP53
15 muscle cell fate commitment GO:0042693 9.4 MYOD1 MYOG
16 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
17 positive regulation of muscle cell differentiation GO:0051149 9.13 CTNNB1 MYOD1 MYOG
18 regulation of gene expression GO:0010468 9.02 CDK4 CTNNB1 MDM2 MYOD1 PEG3

Molecular functions related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 AXIN1 DES MDM2 S100B TP53 VIM
2 ubiquitin protein ligase binding GO:0031625 9.67 AXIN1 MDM2 MYOD1 TP53
3 protein C-terminus binding GO:0008022 9.46 CTNNB1 MKI67 TP53 VIM
4 enzyme binding GO:0019899 9.35 AXIN1 CTNNB1 MDM2 MYOD1 TP53
5 I-SMAD binding GO:0070411 9.26 AXIN1 CTNNB1
6 disordered domain specific binding GO:0097718 8.8 CTNNB1 MDM2 TP53

Sources for Embryonal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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