MCID: EMB007
MIFTS: 42

Embryonal Sarcoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Embryonal Sarcoma

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Embryonal Sarcoma, Aliases & Descriptions:

Name: Embryonal Sarcoma 41
 
Undifferentiated Sarcoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Embryonal Sarcoma

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MalaCards based summary: Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to embryonal rhabdomyosarcoma and fibrous histiocytoma. An important gene associated with Embryonal Sarcoma is CDK4 (cyclin-dependent kinase 4), and among its related pathways are GADD45 Pathway and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are pigmentation and digestive/alimentary.

Related Diseases for Embryonal Sarcoma

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Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma30.4CDK4, MYOG, MYOD1, DES
2fibrous histiocytoma30.3DES, VIM, S100B
3sarcoma30.1DES, MKI67, TP53, VIM, MYOG, S100B
4rhabdomyosarcoma29.7DES, TP53, VIM, MYOD1, MYOG, MDM2
5undifferentiated embryonal sarcoma of the liver11.0
6hepatitis10.6
7alveolar soft-part sarcoma10.6MYOD1
8giant cell glioblastoma10.6MDM2
9dermatofibrosarcoma protuberans10.6MDM2
10adenosarcoma10.6DES
11syringoma10.5S100B
12infantile myofibromatosis10.5DES
13fibrous meningioma10.5S100B
14gemistocytic astrocytoma10.5S100B
15juvenile xanthogranuloma10.5S100B
16carney triad10.5KIT
17malignant mesenchymoma10.5MYOD1, MYOG
18myoma10.4DES, MYOG
19connective tissue benign neoplasm10.4CDK4, MDM2
20choroid plexus papilloma10.4TP53
21gliosarcoma10.4CDK4
22myxoid liposarcoma10.4MDM2, CDK4
23renal cell carcinoma10.4TP53
24anaplastic ependymoma10.4MDM2, S100B
25papilloma10.4TP53
26adenomatoid tumor10.4VIM
27anaplastic oligodendroglioma10.4MDM2, CDK4
28pleomorphic liposarcoma10.4MDM2, KIT
29cutaneous fibrous histiocytoma10.4S100B, DES
30myopathy congenital10.3MYOG, DES
31desmoid disease, hereditary10.3KIT, DES
32glomus tumor10.3DES, VIM
33perineurioma10.3VIM, S100B
34clear cell sarcoma10.3S100B, KIT
35epithelioid leiomyosarcoma10.3DES, VIM
36mesenchymal chondrosarcoma10.3DES, VIM
37lipoma10.3CDK4, MDM2, DES
38spindle cell carcinoma10.3DES, VIM
39uveal melanoma10.3MDM2, CDK4, S100B
40sertoli cell tumor10.3VIM, DES
41uterine sarcoma10.3DES, MDM2, KIT
42myoepithelioma10.3VIM, S100B
43benign meningioma10.2MKI67, MDM2
44malignant mixed mullerian tumor10.2KIT, VIM
45pseudosarcomatous fibromatosis10.2DES, VIM, MYOG
46li-fraumeni syndrome10.2MDM2, TP53
47rhabdoid tumor10.2VIM, DES, MYOD1
48prostatitis10.2
49fibroma10.2VIM, DES
50myopathy10.2MYOD1, DES, MYOG

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to embryonal sarcoma

Symptoms for Embryonal Sarcoma

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Drugs & Therapeutics for Embryonal Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Embryonal Sarcoma

Search NIH Clinical Center for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

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Anatomical Context for Embryonal Sarcoma

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MalaCards organs/tissues related to Embryonal Sarcoma:

31
Liver, Kidney, Lung, Prostate, Brain, Heart, Adrenal gland

Animal Models for Embryonal Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Embryonal Sarcoma:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4GPC3, MDM2, KIT, TP53
2MP:00053818.9GPC3, MDM2, KIT, TP53, CDK4
3MP:00020068.9MYOD1, CDK4, MDM2, KIT, TP53
4MP:00053678.8CDK4, MDM2, KIT, TP53, GPC3
5MP:00107718.5GPC3, TP53, MYOG, CDK4, MDM2, KIT
6MP:00053908.4GPC3, MDM2, KIT, MYOG, MYOD1, TP53
7MP:00053808.4VIM, MYOG, CDK4, MDM2, KIT, TP53
8MP:00053888.3GPC3, KIT, MYOG, MYOD1, VIM, TP53
9MP:00053898.3VIM, TP53, MYOD1, KIT, MDM2, GPC3
10MP:00030128.1TP53, MALAT1, KIT, MDM2, MYOD1
11MP:00053858.1VIM, TP53, GPC3, DES, MDM2, CDK4
12MP:00053978.1SLPI, CDK4, MDM2, KIT, VIM, GPC3
13MP:00053878.0VIM, TP53, KIT, MDM2, CDK4, SLPI
14MP:00053698.0MYOD1, VIM, TP53, DES, MYOG, KIT
15MP:00028738.0S100B, KIT, MDM2, MYOG, MYOD1, TP53
16MP:00053847.8CDK4, TP53, GPC3, VIM, PEG3, KIT
17MP:00053867.4CDK4, PEG3, DES, VIM, MYOG, S100B
18MP:00053767.2DES, MYOD1, GPC3, TP53, VIM, MYOG
19MP:00053787.1VIM, MYOG, PEG3, GPC3, TP53, MYOD1
20MP:00107686.2MYOD1, VIM, TP53, GPC3, PEG3, DES

Publications for Embryonal Sarcoma

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Articles related to Embryonal Sarcoma:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Undifferentiated embryonal sarcoma of the liver: a concise review. (25611111)
2015
2
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. (25120683)
2014
3
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. (25603636)
2014
4
Mesenchymal hamartoma or embryonal sarcoma of the liver in childhood: a difficult diagnosis before complete surgical excision. (25148740)
2014
5
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. (24762610)
2014
6
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
7
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
8
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
9
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
10
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
11
Embryonal sarcoma of the liver in an adult patient. (22690347)
2012
12
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. (25374706)
2012
13
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
14
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
15
Embryonal sarcoma of the liver in an adult mimicking complicated hepatic cyst: MRI findings. (20512902)
2010
16
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
17
A case of embryonal sarcoma of the liver. (21033305)
2010
18
Undifferentiated embryonal sarcoma: a case report. (20207789)
2010
19
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. (19809302)
2010
20
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
21
Primary hepatic embryonal sarcoma masquerading as metastatic ovarian cancer. (19549298)
2009
22
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
23
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
24
Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. (17573940)
2007
25
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
26
Pediatric and adult hepatic embryonal sarcoma: a comparative ultrastructural study with morphologic correlations. (17182431)
2006
27
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
28
Mutation of TP53 gene is involved in carcinogenesis of hepatic undifferentiated (embryonal) sarcoma of the adult, in contrast with Wnt or telomerase pathways: an immunohistochemical study of three cases with genomic relation in two cases. (15710230)
2005
29
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
30
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
31
Cystic embryonal sarcoma of the kidney. (12394750)
2002
32
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
33
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
34
Cystic embryonal sarcoma of kidney: a case report. (9635536)
1998
35
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
36
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
37
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
38
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
39
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
40
Undifferentiated (embryonal) sarcoma arising in conjunction with mesenchymal hamartoma of the liver. (8066077)
1994
41
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
42
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
43
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
44
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
45
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
46
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
47
Embryonal sarcoma of the orbit. A clinical review of 19 Danish cases. (990019)
1976
48
A case of embryonal sarcoma (rhabdomyosarcoma) of the prostate treated with combined surgical and cytostatic therapy. (55104)
1975
49
Embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit. (4284785)
1965
50
Bilateral feline embryonal sarcoma. (13823299)
1960

Variations for Embryonal Sarcoma

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Expression for genes affiliated with Embryonal Sarcoma

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Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for genes affiliated with Embryonal Sarcoma

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Pathways related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, CDK4
29.8TP53, MDM2
39.8TP53, MDM2
4
Show member pathways
9.8TP53, MDM2
5
Show member pathways
9.6TP53, MDM2, CDK4
6
Show member pathways
Signaling Pathways in Glioblastoma36
9.6TP53, MDM2, CDK4
7
Show member pathways
Cell cycle36
9.6TP53, MDM2, CDK4
89.6TP53, MDM2, CDK4
9
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.6TP53, MDM2, CDK4
10
Show member pathways
9.6TP53, MDM2, CDK4
119.6TP53, MDM2, CDK4
129.6TP53, MDM2, CDK4
13
Show member pathways
9.6CDK4, MDM2, TP53
149.6CDK4, MDM2, TP53
159.6CDK4, MDM2, TP53
16
Show member pathways
9.6CDK4, MDM2, TP53
179.6CDK4, MDM2, TP53
189.6CDK4, MDM2, TP53
199.6CDK4, MDM2, TP53
209.6CDK4, MDM2, TP53
21
Show member pathways
DNA damage response36
9.6CDK4, MDM2, TP53
229.5MDM2, TP53, GPC3
23
Show member pathways
9.5MYOD1, MYOG
24
Show member pathways
Signal transduction PTEN pathway58
9.5MDM2, KIT, TP53
259.5CDK4, VIM, TP53
269.4TP53, VIM, MDM2
27
Show member pathways
9.2TP53, KIT, MDM2, CDK4
289.2CDK4, MDM2, KIT, TP53
299.2TP53, KIT, MDM2, CDK4
30
Show member pathways
9.2MKI67, TP53, MDM2, CDK4
31
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
9.2CDK4, MDM2, VIM, TP53
32
Show member pathways
8.6DES, TP53, VIM, KIT, MDM2, CDK4

Compounds for genes affiliated with Embryonal Sarcoma

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Compounds related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1orcein439.9DES, S100B, VIM
2s 100439.8DES, VIM, S100B
3flavopiridol43 1210.5TP53, KIT, MDM2, CDK4
4roscovitine439.5CDK4, VIM, MDM2, TP53
5gefitinib43 49 1211.4KIT, CDK4, MDM2, VIM
6valine439.3CDK4, MDM2, S100B, KIT, VIM
7toluidine439.2VIM, KIT, DES
8thymidylate439.2MDM2, VIM, TP53, MKI67, CDK4
9formaldehyde43 2410.2MKI67, DES, S100B, VIM, KIT
10vincristine43 49 1211.1MDM2, MKI67, TP53, VIM, KIT
11geldanamycin43 49 59 1212.1CDK4, MYOD1, TP53, MDM2, KIT
125fluorouracil439.1MKI67, KIT, MDM2, CDK4, TP53
13irinotecan43 49 1211.0TP53, KIT, MDM2, MKI67
14glycogen43 249.8DES, MKI67, VIM, S100B, KIT, MDM2
15iron43 249.7CDK4, MDM2, DES, SLPI, VIM, S100B
16tgf beta1438.7SLPI, VIM, MYOD1, CDK4, MKI67
17hematoxylin438.7KIT, S100B, VIM, SLPI, MKI67, DES
18estradiol43 24 1210.7DES, SLPI, VIM, MDM2, MKI67, CDK4
19proline438.7VIM, MDM2, MKI67, CDK4, S100B, DES
20doxorubicin43 49 1210.7MDM2, DES, MKI67, TP53, VIM, KIT
21paclitaxel43 49 1210.7MKI67, TP53, VIM, S100B, KIT, MDM2
2212-o-tetradecanoylphorbol 13-acetate438.6DES, CDK4, MYOG, MYOD1, VIM
23methionine438.6KIT, SLPI, S100B, VIM, DES
24ascorbic acid43 249.6SLPI, MKI67, CDK4, MYOG, S100B
25threonine438.5CDK4, DES, MKI67, MYOD1, S100B, KIT
26lactate438.5DES, VIM, S100B, KIT, SLPI, MKI67
27bromodeoxyuridine438.4MYOD1, DES, MKI67, VIM, CDK4, S100B
28progesterone43 28 59 24 1212.4CDK4, KIT, S100B, VIM, TP53, MKI67
29cyclic amp43 249.3DES, VIM, MYOD1, S100B, MDM2, CDK4
30cycloheximide438.3SLPI, MDM2, KIT, MKI67, TP53, CDK4
31butyrate438.2MYOD1, TP53, VIM, CDK4, SLPI, MYOG
325-aza-2deoxycytidine438.2MDM2, PEG3, GPC3, TP53, MYOD1, VIM
33arginine438.2MKI67, MDM2, S100B, MYOD1, VIM, CDK4
34thymidine43 249.2CDK4, DES, MKI67, TP53, S100B, KIT
35creatinine438.2MYOD1, DES, VIM, MYOG, SLPI, S100B
36actinomycin d438.1MYOD1, DES, VIM, SLPI, TP53, MDM2
37nitric oxide43 24 1210.1KIT, S100B, MYOG, MKI67, DES, MDM2
38oxygen43 248.9SLPI, MDM2, S100B, CDK4, MYOG, MYOD1
39glucose437.8MYOD1, MKI67, DES, S100B, KIT, CDK4
40steroid437.6CDK4, SLPI, DES, MDM2, KIT, S100B
41cysteine437.6SLPI, MDM2, DES, VIM, MYOD1, MYOG
42tyrosine437.5DES, S100B, MYOG, KIT, MDM2, CDK4
43paraffin437.5MDM2, KIT, S100B, MYOG, VIM, TP53
44oligonucleotide437.4GPC3, TP53, VIM, MYOD1, MYOG, KIT
45calcium43 49 24 1210.3DES, MYOG, CDK4, MDM2, KIT, S100B
46testosterone43 59 24 1210.2MKI67, VIM, MYOG, S100B, DES, KIT
47retinoic acid43 248.1TP53, MKI67, DES, MYOD1, MYOG, VIM
48estrogen436.8MKI67, TP53, SLPI, CDK4, KIT, S100B
49serine436.8TP53, S100B, SLPI, CDK4, MDM2, KIT
50vegf436.0SLPI, DES, PEG3, CDK4, MDM2, KIT

GO Terms for genes affiliated with Embryonal Sarcoma

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Cellular components related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.7MDM2, TP53
2transcription factor complexGO:00056679.0MYOD1, MYOG, CDK4
3nucleoplasmGO:00056548.6CDK4, MDM2, MYOG, MYOD1, TP53
4nucleusGO:00056347.1CDK4, MDM2, S100B, MYOG, MYOD1, TP53

Biological processes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:007115710.1MDM2, CDK4
2cellular response to hypoxiaGO:00714569.7MDM2, S100B, TP53
3muscle cell fate commitmentGO:00426939.7MYOG, MYOD1
4positive regulation of cell cycle arrestGO:00711589.6MYOG, TP53
5skeletal muscle fiber developmentGO:00487419.6MYOD1, MYOG
6cellular response to estradiol stimulusGO:00713929.6MYOG, MYOD1
7positive regulation of cell proliferationGO:00082849.6S100B, KIT, MDM2, CDK4
8response to antibioticGO:00466779.5MDM2, TP53
9muscle cell differentiationGO:00426929.5MYOG, MYOD1
10positive regulation of muscle cell differentiationGO:00511499.4MYOD1, MYOG

Molecular functions related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.9MDM2, VIM
2RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00012289.8TP53, MYOG
3chromatin DNA bindingGO:00314909.5MYOD1, MYOG
4ubiquitin protein ligase bindingGO:00316259.4MDM2, MYOD1, TP53
5E-box bindingGO:00708889.4MYOG, MYOD1
6core promoter bindingGO:00010479.2MYOG, MYOD1
7enzyme bindingGO:00198999.2SLPI, MDM2, TP53
8identical protein bindingGO:00428029.1DES, TP53, VIM, S100B, MDM2
9protein bindingGO:00055156.7SLPI, DES, MKI67, GPC3, TP53, VIM

Products for genes affiliated with Embryonal Sarcoma

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Sources for Embryonal Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet