MCID: EMB007
MIFTS: 43

Embryonal Sarcoma malady

Cancer category

Summaries for Embryonal Sarcoma

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33MalaCards
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MalaCards: Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to angiosarcoma and adenoma. An important gene associated with Embryonal Sarcoma is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are Cell cycle and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds estrogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Embryonal Sarcoma

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

embryonal sarcoma 43
undifferentiated sarcoma 61


Related Diseases for Embryonal Sarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1angiosarcoma30.0SERPINA3, VIM
2adenoma30.0CDK4, MYOD1, TP53, MKI67
3ependymoma30.0MDM2, VIM, S100B, MKI67
4fibrous histiocytoma30.0S100B, SERPINA3, VIM, DES
5pleomorphic undifferentiated sarcoma10.5
6undifferentiated embryonal sarcoma of the liver10.3
7cardiac tamponade10.0
8liver angiosarcoma10.0
9penis sarcoma10.0
10extraskeletal myxoid chondrosarcoma10.0
11bone ewing's sarcoma10.0
12brain ependymoma10.0
13hellp syndrome10.0
14blastoma10.0
15orbit embryonal rhabdomyosarcoma10.0
16prostate embryonal rhabdomyosarcoma10.0
17systemic lupus erythematosus10.0
18liver rhabdomyosarcoma10.0
19brain sarcoma10.0
20appendicitis10.0
21bladder sarcoma10.0
22gliosarcoma10.0CDK4
23dermatofibrosarcoma10.0MDM2
24alveolar soft part sarcoma10.0MYOD1
25giant cell glioblastoma10.0MDM2
26histiocytosis10.0S100B
27hemangioblastoma10.0S100B
28arthritis10.0SERPINA3
29peritonitis10.0SLPI
30wegener's granulomatosis10.0SLPI
31syringoma10.0S100B
32germ cell tumors10.0KIT
33uterine carcinosarcoma10.0KIT
34adenosarcoma10.0DES
35fibrous meningioma10.0S100B
36myelodysplastic syndromes10.0KIT
37infantile myofibromatosis10.0DES
38kidney cancer10.0TP53
39acute leukemia10.0KIT
40hepatoblastoma10.0GPC3
41thyroid cancer10.0TP53
42lymphangioleiomyomatosis10.0DES
43hepatitis10.0GPC3
44gemistocytic astrocytoma10.0S100B
45malignant mesenchymoma10.0MYOG, MYOD1
46ductal carcinoma in situ10.0TP53
47neuroblastoma10.0TP53
48juvenile xanthogranuloma10.0S100B
49malignant fibroxanthoma10.0TP53
50papilloma10.0TP53

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to embryonal sarcoma

Clinical Features for Embryonal Sarcoma

Drugs & Therapeutics for Embryonal Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Embryonal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Embryonal Sarcoma

Search NIH Clinical Center for Embryonal Sarcoma

Search CenterWatch for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

Anatomical Context for Embryonal Sarcoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Embryonal Sarcoma:

33
Brain, Heart, Smooth muscle, Kidney, Liver, Lung, Adrenal gland, Prostate, Cervix, T cells

Animal Models for Embryonal Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Embryonal Sarcoma

Sources:
51PubMed
See all sources

Articles related to Embryonal Sarcoma:

(show top 50)    (show all 153)
idTitleAuthorsYear
1
Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma. (24142883)
2014
2
Embryonal sarcoma of the liver in an adult patient. (22690347)
2012
3
A long-term survival case of adult undifferentiated embryonal sarcoma of liver. (22540346)
2012
4
Undifferentiated embryonal sarcoma of the liver in an adult patient: case report. (22798120)
2012
5
Undifferentiated (embryonal) liver sarcoma: synchronous and metachronous occurrence with neoplasms other than mesenchymal liver hamartoma. (21414822)
2011
6
Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group. (21618411)
2011
7
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. (20925497)
2011
8
A case of embryonal sarcoma of the liver. (21033305)
2010
9
Undifferentiated embryonal sarcoma: a case report. (20207789)
2010
10
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
11
A case of embryonal sarcoma of the liver mimicking a hydatid cyst in an adult. (20559529)
2010
12
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of liver in an adult male. (19937942)
2010
13
Trisomy 8 as a sole aberration in embryonal rhabdomyosarcoma (sarcoma botryoides) of the vagina. (19963119)
2009
14
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
15
Embryonal sarcoma of the liver in a young. (19221536)
2009
16
Liver transplant for relapsed undifferentiated embryonal sarcoma in a young child. (20005995)
2009
17
Childhood undifferentiated embryonal liver sarcoma: clinical features and immunohistochemistry analysis. (18926232)
2008
18
Management of undifferentiated embryonal sarcoma of the liver in pregnancy. (17267894)
2007
19
Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. (17378682)
2007
20
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
21
Pregnancy and delivery in a patient with metastatic embryonal sarcoma of the liver. (11975972)
2002
22
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
23
Hepatic undifferentiated embryonal sarcoma: malignant evolution of mesenchymal hamartoma? Study of one case with immunohistochemical and flow cytometric emphasis. (11211901)
2001
24
Hepatic undifferentiated (embryonal) sarcoma in an adult: a case report and review of the literature. (11111784)
2000
25
Embryonal sarcoma of the liver: multiple recurrences and histologic dedifferentiation. (10219344)
1999
26
Cystic embryonal sarcoma of kidney: a case report. (9635536)
1998
27
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
28
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
29
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
30
Hepatic undifferentiated embryonal sarcoma: MR findings. (9022777)
1997
31
Primary multilocular cystic undifferentiated (embryonal) sarcoma of the liver in childhood resembling hydatid cyst of the liver. (9166061)
1997
32
Cytopathology of undifferentiated (embryonal) sarcoma of the liver. (7587875)
1995
33
Primary multicystic undifferentiated embryonal sarcoma of the liver in an adult presenting with peripheral eosinophilia. (7847778)
1994
34
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
35
Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. (1727675)
1992
36
Undifferentiated (embryonal) sarcoma of the liver: report of three cases. (1421867)
1992
37
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
38
Undifferentiated (embryonal) sarcoma of the liver. A clinicopathologic study of a survivor treated with combined technique therapy. (2766226)
1989
39
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
40
Undifferentiated (embryonal) sarcoma of the liver: ultrastructural and immunohistochemical similarities with malignant fibrous histiocytoma. (2989150)
1985
41
Undifferentiated (embryonal) liver sarcoma of childhood: evidence of leiomyoblastic differentiation. (6687281)
1983
42
Embryonal rhabdomyosarcoma of the middle ear presenting as sarcoma botryoides. Favorable outcome in a 12-year-old boy. (7085331)
1982
43
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
44
Undifferentiated (embryonal) sarcoma of the liver. (7395519)
1980
45
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the common bile duct: a case report. (992649)
1976
46
Embryonal sarcoma of the lower urinary tract in children: 5-year survival in 2 cases after radical treatment. (4136714)
1974
47
An ultrastructural study of embryonal rhabdomyosarcoma (Sarcoma botryoides) of the bladder. (4349351)
1973
48
Embryonal sarcoma of the prostate in infancy and childhood. Report of four cases. (5099270)
1971
49
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the middle ear. (5502806)
1970
50
Embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit. (4284785)
1965

Genetic Variations for Embryonal Sarcoma

Expression for genes affiliated with Embryonal Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for genes affiliated with Embryonal Sarcoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8TP53, MDM2
29.8MDM2, TP53
39.8TP53, MDM2
4
Hide members
9.5MDM2, TP53, CDK4
5
Hide members
9.5CDK4, TP53, MDM2
69.5TP53, CDK4, MDM2
7
Hide members
9.5TP53, CDK4, MDM2
89.5TP53, CDK4, MDM2
9
Transcription P53 signaling pathway
Hide members
9.5MDM2, TP53, CDK4
10
Hide members
9.4AXIN1, TP53, KIT
119.4VIM, CDK4, TP53
12
Hide members
9.2VIM, MDM2, CDK4, AXIN1
139.2AXIN1, MDM2, CDK4, TP53
149.2KIT, MDM2, CDK4, TP53
15
Hide members
9.1AXIN1, MDM2, KIT, TP53
168.9CDK4, AXIN1, TP53, MDM2, KIT
17
Hide members
8.1VIM, MDM2, DES, CDK4, AXIN1, KIT

Compounds for genes affiliated with Embryonal Sarcoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
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Compounds related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1estrogen459.8MYOD1, MYOG
2orcein459.8VIM, DES, S100B
3butyrate459.7MYOD1, MYOG
4s 100459.7DES, S100B, VIM
5paclitaxel45 50 1111.6MDM2, S100B, TP53, CDK4
6vincristine45 50 1111.5KIT, MKI67, VIM
7acetylcholine45 50 29 11 2413.4MYOD1, MYOG, SERPINA3
8toluidine459.4DES, VIM, KIT
9flavopiridol45 1110.3MDM2, CDK4, TP53, KIT
10roscovitine459.3VIM, MDM2, CDK4, TP53
11glucose459.3MYOG, SLPI, SERPINA3
12creatinine459.1MYOD1, SERPINA3, SLPI
13valine459.1CDK4, SERPINA3, VIM, MDM2, S100B, KIT
14thymidylate458.9MDM2, MKI67, CDK4, TP53, VIM
15geldanamycin45 50 60 1111.9KIT, TP53, MYOD1, MDM2, CDK4
16formaldehyde45 249.9DES, S100B, VIM, KIT, MKI67
17methotrexate45 50 1110.8SERPINA3, VIM, MDM2, MKI67, KIT
185fluorouracil458.6MKI67, MDM2, CDK4, TP53, KIT
195-aza-2deoxycytidine458.6GPC3, TP53, MDM2, MYOD1, VIM
20irinotecan45 50 1110.6TP53, MKI67, KIT, MDM2
21glycogen45 249.5KIT, CDK4, MKI67, DES, MDM2, S100B
22serine458.4MYOD1, S100B, SERPINA3, MYOG, MKI67, DES
23methionine458.4SLPI, KIT, DES, S100B, VIM, SERPINA3
24proline458.3TP53, DES, MDM2, S100B, VIM, MKI67
25doxorubicin45 50 1110.3KIT, CDK4, MKI67, DES, MDM2, VIM
26iron45 249.3DES, CDK4, SLPI, MDM2, SERPINA3, S100B
27leucine458.2CDK4, S100B, VIM, MYOD1, SERPINA3, KIT
28hematoxylin458.2MKI67, VIM, SLPI, KIT, DES, S100B
29tgf beta1458.1CDK4, SLPI, VIM, MKI67, MYOD1
30estradiol45 11 2410.0DES, MDM2, VIM, MKI67, CDK4, SLPI
31threonine458.0MKI67, KIT, S100B, MDM2, DES, MYOD1
32bromodeoxyuridine458.0S100B, MKI67, MYOD1, MYOG, CDK4, DES
33lactate457.9SLPI, KIT, MKI67, DES, S100B, VIM
34cyclic amp45 248.8VIM, CDK4, SLPI, MYOD1, DES, MDM2
35progesterone45 60 29 11 2411.8MDM2, VIM, TP53, SERPINA3, KIT, CDK4
36alanine457.6VIM, S100B, MDM2, MYOD1, CDK4, SLPI
37actinomycin d457.6KIT, VIM, MDM2, DES, MYOD1, SLPI
38thymidine45 248.6TP53, MKI67, CDK4, KIT, SLPI, DES
39arginine457.5VIM, MDM2, DES, MKI67, MYOD1, CDK4
40nitric oxide45 11 249.5S100B, SLPI, MDM2, MYOG, DES, CDK4
41calcium45 50 11 2410.3S100B, MYOD1, CDK4, DES, KIT, SERPINA3
42steroid457.3DES, CDK4, MDM2, MKI67, MYOD1, MYOG
43oxygen45 248.0S100B, SERPINA3, MYOD1, SLPI, CDK4, MKI67
44cysteine456.8MYOG, DES, MDM2, CDK4, KIT, SLPI
45tyrosine456.7MYOG, SLPI, KIT, S100B, MDM2, DES
46paraffin456.7SERPINA3, CDK4, KIT, MYOG, DES, MYOD1
47oligonucleotide456.6VIM, KIT, MDM2, MYOD1, MYOG, CDK4
48testosterone45 60 11 249.5MYOD1, MYOG, KIT, SLPI, MKI67, DES
49retinoic acid45 247.1SLPI, SERPINA3, VIM, CDK4, KIT, MYOG
50vegf456.1TP53, SLPI, CDK4, KIT, MYOG, MKI67

GO Terms for genes affiliated with Embryonal Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.7TP53, MDM2, MKI67, MYOD1, MYOG, CDK4

Biological processes related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:0714569.5TP53, MDM2, S100B
2muscle cell fate commitmentGO:0426939.4MYOG, MYOD1
3skeletal muscle fiber developmentGO:0487419.3MYOG, MYOD1
4positive regulation of cell proliferationGO:0082849.3KIT, CDK4, MDM2, S100B
5cellular response to estradiol stimulusGO:0713929.2MYOD1, MYOG
6positive regulation of cell cycle arrestGO:0711589.2TP53, MYOG

Molecular functions related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.5TP53, AXIN1, MDM2
2RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positiGO:0012289.2MYOG, TP53
3ubiquitin protein ligase bindingGO:0316259.1AXIN1, TP53, MYOD1
4enzyme bindingGO:0198998.5TP53, SLPI, AXIN1, MDM2
5identical protein bindingGO:0428028.5AXIN1, DES, MDM2, TP53, S100B, VIM
6protein bindingGO:0055155.4MDM2, S100B, DES, MKI67, MYOD1, CDK4

Products for genes affiliated with Embryonal Sarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Embryonal Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet