MCID: EMB007
MIFTS: 49

Embryonal Sarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Embryonal Sarcoma

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MalaCards based summary: Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to embryonal rhabdomyosarcoma and fibrous histiocytoma. An important gene associated with Embryonal Sarcoma is CDK4 (cyclin-dependent kinase 4), and among its related pathways are GADD45 Pathway and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Embryonal Sarcoma

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Embryonal Sarcoma, Aliases & Descriptions:

Name: Embryonal Sarcoma 42
 
Undifferentiated Sarcoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Embryonal Sarcoma

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Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma30.4DES, MYOD1, MYOG, CDK4
2fibrous histiocytoma30.4DES, VIM, S100B
3sarcoma30.1MKI67, TP53, VIM, MYOD1, MYOG, S100B
4ovarian cancer30.0TP53, MDM2, CDK4, SLPI
5rhabdomyosarcoma29.7S100B, MDM2, CDK4, MYOG, MYOD1, VIM
6undifferentiated embryonal sarcoma of the liver11.0
7hepatitis10.6
8alveolar soft part sarcoma10.6MYOD1
9giant cell glioblastoma10.6MDM2
10dermatofibrosarcoma protuberans10.6MDM2
11adenosarcoma10.6DES
12syringoma10.5S100B
13infantile myofibromatosis10.5DES
14fibrous meningioma10.5S100B
15gemistocytic astrocytoma10.5S100B
16juvenile xanthogranuloma10.5S100B
17carney triad10.5KIT
18malignant mesenchymoma10.5MYOD1, MYOG
19myoma10.4DES, MYOG
20choroid plexus papilloma10.4TP53
21gliosarcoma10.4CDK4
22myxoid liposarcoma10.4MDM2, CDK4
23kidney cancer10.4TP53
24anaplastic ependymoma10.4S100B, MDM2
25papilloma10.4TP53
26adenomatoid tumor10.4VIM
27pleomorphic liposarcoma10.4MDM2, KIT
28cutaneous fibrous histiocytoma10.4DES, S100B
29anaplastic oligodendroglioma10.4CDK4, MDM2
30myopathy congenital10.3DES, MYOG
31desmoid tumor10.3DES, KIT
32paraganglioma10.3VIM, DES
33perineurioma10.3VIM, S100B
34clear cell sarcoma10.3KIT, S100B
35epithelioid leiomyosarcoma10.3VIM, DES
36mesenchymal chondrosarcoma10.3DES, VIM
37lipoma10.3CDK4, MDM2, DES
38spindle cell carcinoma10.3DES, VIM
39uveal melanoma10.3S100B, MDM2, CDK4
40sertoli cell tumor10.3DES, VIM
41myoepithelioma10.3VIM, S100B
42uterine sarcoma10.3DES, KIT, MDM2
43malignant mixed mullerian tumor10.2VIM, KIT
44benign meningioma10.2MKI67, MDM2
45pseudosarcomatous fibromatosis10.2DES, VIM, MYOG
46li-fraumeni syndrome10.2TP53, MDM2
47fibroma10.2DES, VIM
48rhabdoid tumor10.2DES, VIM, MYOD1
49prostatitis10.2
50myopathy10.2DES, MYOD1, MYOG

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to embryonal sarcoma

Symptoms for Embryonal Sarcoma

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Drugs & Therapeutics for Embryonal Sarcoma

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Drug clinical trials:

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Search NIH Clinical Center for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

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Anatomical Context for Embryonal Sarcoma

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MalaCards organs/tissues related to Embryonal Sarcoma:

32
Liver, Kidney, Lung, Prostate, Brain, Heart, Smooth muscle, Adrenal gland

Animal Models for Embryonal Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Embryonal Sarcoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4GPC3, TP53, KIT, MDM2
2MP:00053818.9CDK4, MDM2, KIT, TP53, GPC3
3MP:00020068.9TP53, MYOD1, KIT, MDM2, CDK4
4MP:00053678.8GPC3, TP53, KIT, MDM2, CDK4
5MP:00107718.5GPC3, TP53, MYOG, S100B, KIT, MDM2
6MP:00053908.4GPC3, TP53, MYOD1, MYOG, KIT, MDM2
7MP:00053808.4GPC3, TP53, VIM, MYOG, KIT, MDM2
8MP:00053888.3GPC3, TP53, VIM, MYOD1, MYOG, KIT
9MP:00053898.3GPC3, TP53, VIM, MYOD1, KIT, MDM2
10MP:00030128.1TP53, MYOD1, MALAT1, KIT, MDM2
11MP:00053858.1DES, GPC3, TP53, VIM, MYOD1, KIT
12MP:00053978.1GPC3, TP53, VIM, KIT, MDM2, CDK4
13MP:00053878.0GPC3, TP53, VIM, KIT, MDM2, CDK4
14MP:00053698.0CDK4, DES, TP53, VIM, MYOD1, MYOG
15MP:00028738.0TP53, MYOD1, MYOG, MALAT1, S100B, KIT
16MP:00053847.8PEG3, GPC3, TP53, VIM, KIT, MDM2
17MP:00053867.4DES, PEG3, TP53, VIM, MYOG, S100B
18MP:00053767.2DES, GPC3, TP53, VIM, MYOD1, MYOG
19MP:00053787.1PEG3, GPC3, TP53, VIM, MYOD1, MYOG
20MP:00107686.2DES, PEG3, GPC3, TP53, VIM, MYOD1

Publications for Embryonal Sarcoma

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Articles related to Embryonal Sarcoma:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. (25120683)
2014
2
Mesenchymal hamartoma or embryonal sarcoma of the liver in childhood: a difficult diagnosis before complete surgical excision. (25148740)
2014
3
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. (24762610)
2014
4
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
5
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
6
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
7
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
8
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
9
Embryonal sarcoma of the liver in an adult patient. (22690347)
2012
10
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. (25374706)
2012
11
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
12
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
13
Embryonal sarcoma of the liver in an adult mimicking complicated hepatic cyst: MRI findings. (20512902)
2010
14
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
15
A case of embryonal sarcoma of the liver. (21033305)
2010
16
Undifferentiated embryonal sarcoma: a case report. (20207789)
2010
17
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. (19809302)
2010
18
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
19
Primary hepatic embryonal sarcoma masquerading as metastatic ovarian cancer. (19549298)
2009
20
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
21
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
22
Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. (17573940)
2007
23
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
24
Pediatric and adult hepatic embryonal sarcoma: a comparative ultrastructural study with morphologic correlations. (17182431)
2006
25
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
26
Mutation of TP53 gene is involved in carcinogenesis of hepatic undifferentiated (embryonal) sarcoma of the adult, in contrast with Wnt or telomerase pathways: an immunohistochemical study of three cases with genomic relation in two cases. (15710230)
2005
27
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
28
Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy. (12673559)
2003
29
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
30
Cystic embryonal sarcoma of the kidney. (12394750)
2002
31
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
32
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
33
Cystic embryonal sarcoma of kidney: a case report. (9635536)
1998
34
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
35
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
36
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
37
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
38
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
39
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
40
Undifferentiated (embryonal) sarcoma arising in conjunction with mesenchymal hamartoma of the liver. (8066077)
1994
41
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
42
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
43
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
44
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
45
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
46
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
47
Embryonal sarcoma of the orbit. A clinical review of 19 Danish cases. (990019)
1976
48
A case of embryonal sarcoma (rhabdomyosarcoma) of the prostate treated with combined surgical and cytostatic therapy. (55104)
1975
49
Embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit. (4284785)
1965
50
Bilateral feline embryonal sarcoma. (13823299)
1960

Variations for Embryonal Sarcoma

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Expression for genes affiliated with Embryonal Sarcoma

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Expression patterns in normal tissues for genes affiliated with Embryonal Sarcoma

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Pathways for genes affiliated with Embryonal Sarcoma

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Pathways related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, CDK4
29.8TP53, MDM2
39.8TP53, MDM2
4
Show member pathways
9.8TP53, MDM2
5
Show member pathways
9.6TP53, MDM2, CDK4
6
Show member pathways
Signaling Pathways in Glioblastoma37
9.6TP53, MDM2, CDK4
7
Show member pathways
Cell cycle37
9.6TP53, MDM2, CDK4
89.6TP53, MDM2, CDK4
9
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.6TP53, MDM2, CDK4
10
Show member pathways
9.6TP53, MDM2, CDK4
119.6TP53, MDM2, CDK4
129.6TP53, MDM2, CDK4
13
Show member pathways
9.6CDK4, MDM2, TP53
149.6CDK4, MDM2, TP53
159.6CDK4, MDM2, TP53
16
Show member pathways
9.6CDK4, MDM2, TP53
179.6CDK4, MDM2, TP53
189.6CDK4, MDM2, TP53
199.6CDK4, MDM2, TP53
209.6CDK4, MDM2, TP53
21
Show member pathways
DNA damage response37
9.6CDK4, MDM2, TP53
229.5MDM2, TP53, GPC3
23
Show member pathways
9.5MYOD1, MYOG
24
Show member pathways
Signal transduction PTEN pathway60
9.5MDM2, KIT, TP53
259.5CDK4, VIM, TP53
269.4TP53, VIM, MDM2
27
Show member pathways
9.2TP53, KIT, MDM2, CDK4
289.2CDK4, MDM2, KIT, TP53
299.2TP53, KIT, MDM2, CDK4
30
Show member pathways
9.2MKI67, TP53, MDM2, CDK4
31
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.2CDK4, MDM2, VIM, TP53
32
Show member pathways
8.6DES, TP53, VIM, KIT, MDM2, CDK4

Compounds for genes affiliated with Embryonal Sarcoma

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Compounds related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1orcein449.9DES, S100B, VIM
2s 100449.8DES, VIM, S100B
3flavopiridol44 1110.5TP53, KIT, MDM2, CDK4
4roscovitine449.5CDK4, VIM, MDM2, TP53
5gefitinib44 50 1111.4KIT, CDK4, MDM2, VIM
6valine449.3CDK4, MDM2, S100B, KIT, VIM
7toluidine449.2VIM, KIT, DES
8thymidylate449.2MDM2, VIM, TP53, MKI67, CDK4
9formaldehyde44 2410.2MKI67, DES, S100B, VIM, KIT
10vincristine44 50 1111.1MDM2, MKI67, TP53, VIM, KIT
11geldanamycin44 50 61 1112.1CDK4, MYOD1, TP53, MDM2, KIT
125fluorouracil449.1MKI67, KIT, MDM2, CDK4, TP53
13irinotecan44 50 1111.0TP53, KIT, MDM2, MKI67
14glycogen44 249.8DES, MKI67, VIM, S100B, KIT, MDM2
15iron44 249.7CDK4, MDM2, DES, SLPI, VIM, S100B
16tgf beta1448.7SLPI, VIM, MYOD1, CDK4, MKI67
17hematoxylin448.7KIT, S100B, VIM, SLPI, MKI67, DES
18estradiol44 24 1110.7DES, SLPI, VIM, MDM2, MKI67, CDK4
19proline448.7VIM, MDM2, MKI67, CDK4, S100B, DES
20doxorubicin44 50 1110.7MDM2, DES, MKI67, TP53, VIM, KIT
21paclitaxel44 50 1110.7MKI67, TP53, VIM, S100B, KIT, MDM2
2212-o-tetradecanoylphorbol 13-acetate448.6DES, CDK4, MYOG, MYOD1, VIM
23methionine448.6KIT, SLPI, S100B, VIM, DES
24ascorbic acid44 249.6SLPI, MKI67, CDK4, MYOG, S100B
25threonine448.5CDK4, DES, MKI67, MYOD1, S100B, KIT
26lactate448.5DES, VIM, S100B, KIT, SLPI, MKI67
27bromodeoxyuridine448.4MYOD1, DES, MKI67, VIM, CDK4, S100B
28progesterone44 28 61 24 1112.4CDK4, KIT, S100B, VIM, TP53, MKI67
29cyclic amp44 249.3DES, VIM, MYOD1, S100B, MDM2, CDK4
30cycloheximide448.3SLPI, MDM2, KIT, MKI67, TP53, CDK4
31butyrate448.2MYOD1, TP53, VIM, CDK4, SLPI, MYOG
325-aza-2deoxycytidine448.2MDM2, PEG3, GPC3, TP53, MYOD1, VIM
33arginine448.2MKI67, MDM2, S100B, MYOD1, VIM, CDK4
34thymidine44 249.2CDK4, DES, MKI67, TP53, S100B, KIT
35creatinine448.2MYOD1, DES, VIM, MYOG, SLPI, S100B
36actinomycin d448.1MYOD1, DES, VIM, SLPI, TP53, MDM2
37nitric oxide44 24 1110.1KIT, S100B, MYOG, MKI67, DES, MDM2
38oxygen44 248.9SLPI, MDM2, S100B, CDK4, MYOG, MYOD1
39glucose447.8MYOD1, MKI67, DES, S100B, KIT, CDK4
40steroid447.6CDK4, SLPI, DES, MDM2, KIT, S100B
41cysteine447.6SLPI, MDM2, DES, VIM, MYOD1, MYOG
42tyrosine447.5DES, S100B, MYOG, KIT, MDM2, CDK4
43paraffin447.5MDM2, KIT, S100B, MYOG, VIM, TP53
44oligonucleotide447.4GPC3, TP53, VIM, MYOD1, MYOG, KIT
45calcium44 50 24 1110.3DES, MYOG, CDK4, MDM2, KIT, S100B
46testosterone44 61 24 1110.2MKI67, VIM, MYOG, S100B, DES, KIT
47retinoic acid44 248.1TP53, MKI67, DES, MYOD1, MYOG, VIM
48estrogen446.8MKI67, TP53, SLPI, CDK4, KIT, S100B
49serine446.8TP53, S100B, SLPI, CDK4, MDM2, KIT
50vegf446.0SLPI, DES, PEG3, CDK4, MDM2, KIT

GO Terms for genes affiliated with Embryonal Sarcoma

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Cellular components related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.7MDM2, TP53
2transcription factor complexGO:0056679.0MYOD1, MYOG, CDK4
3nucleoplasmGO:0056548.6CDK4, MDM2, MYOG, MYOD1, TP53
4nucleusGO:0056347.1CDK4, MDM2, S100B, MYOG, MYOD1, TP53

Biological processes related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.1MDM2, CDK4
2cellular response to hypoxiaGO:0714569.7MDM2, S100B, TP53
3muscle cell fate commitmentGO:0426939.7MYOG, MYOD1
4positive regulation of cell cycle arrestGO:0711589.6MYOG, TP53
5skeletal muscle fiber developmentGO:0487419.6MYOD1, MYOG
6cellular response to estradiol stimulusGO:0713929.6MYOG, MYOD1
7positive regulation of cell proliferationGO:0082849.6S100B, KIT, MDM2, CDK4
8response to antibioticGO:0466779.5MDM2, TP53
9muscle cell differentiationGO:0426929.5MYOG, MYOD1
10positive regulation of muscle cell differentiationGO:0511499.4MYOD1, MYOG

Molecular functions related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.9MDM2, VIM
2RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0012289.8TP53, MYOG
3chromatin DNA bindingGO:0314909.5MYOD1, MYOG
4ubiquitin protein ligase bindingGO:0316259.4MDM2, MYOD1, TP53
5E-box bindingGO:0708889.4MYOG, MYOD1
6core promoter bindingGO:0010479.2MYOG, MYOD1
7enzyme bindingGO:0198999.2SLPI, MDM2, TP53
8identical protein bindingGO:0428029.1DES, TP53, VIM, S100B, MDM2
9protein bindingGO:0055156.7SLPI, DES, MKI67, GPC3, TP53, VIM

Products for genes affiliated with Embryonal Sarcoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Embryonal Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet