MCID: EMB007
MIFTS: 49

Embryonal Sarcoma malady

Rare diseases, Cancer diseases categories

Summaries for Embryonal Sarcoma

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34MalaCards
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MalaCards: Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to sarcoma and rhabdomyosarcoma. An important gene associated with Embryonal Sarcoma is CDK4 (cyclin-dependent kinase 4), and among its related pathways are GADD45 Pathway and Aurora A signaling. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Embryonal Sarcoma

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

embryonal sarcoma 44
undifferentiated sarcoma 63


Related Diseases for Embryonal Sarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.2DES, MKI67, TP53, VIM, MYOG, S100B
2rhabdomyosarcoma30.3DES, TP53, VIM, MYOD1, MYOG, MDM2
3embryonal rhabdomyosarcoma30.1CDK4, MYOG, MYOD1, DES
4fibrous histiocytoma30.1DES, VIM, S100B
5ovarian cancer30.0MDM2, TP53, CDK4, SLPI
6undifferentiated embryonal sarcoma of the liver11.0
7hepatitis10.6
8prostatitis10.2
9alveolar soft part sarcoma10.1MYOD1
10giant cell glioblastoma10.1MDM2
11dermatofibrosarcoma10.1MDM2
12adenosarcoma10.1DES
13syringoma10.1S100B
14infantile myofibromatosis10.1DES
15fibrous meningioma10.1S100B
16gemistocytic astrocytoma10.1S100B
17juvenile xanthogranuloma10.1S100B
18carney triad10.1KIT
19malignant mesenchymoma10.1MYOD1, MYOG
20choroid plexus papilloma10.1TP53
21gliosarcoma10.1CDK4
22myxoid liposarcoma10.1MDM2, CDK4
23kidney cancer10.1TP53
24anaplastic ependymoma10.1MDM2, S100B
25papilloma10.1TP53
26adenomatoid tumor10.1VIM
27anaplastic oligodendroglioma10.1MDM2, CDK4
28pleomorphic liposarcoma10.1MDM2, KIT
29cutaneous fibrous histiocytoma10.1S100B, DES
30myopathy congenital10.1MYOG, DES
31desmoid tumor10.1KIT, DES
32glomus tumor10.1DES, VIM
33perineurioma10.1VIM, S100B
34clear cell sarcoma10.1S100B, KIT
35epithelioid leiomyosarcoma10.1DES, VIM
36mesenchymal chondrosarcoma10.1DES, VIM
37lipoma10.1CDK4, MDM2, DES
38spindle cell carcinoma10.1DES, VIM
39intraocular melanoma10.1MDM2, CDK4, S100B
40sertoli cell tumor10.1VIM, DES
41myoepithelioma10.1VIM, S100B
42uterine sarcoma10.1DES, MDM2, KIT
43benign meningioma10.1MKI67, MDM2
44malignant mixed mullerian tumor10.1KIT, VIM
45pseudosarcomatous fibromatosis10.1DES, VIM, MYOG
46li-fraumeni syndrome10.1MDM2, TP53
47rhabdoid tumor10.0VIM, DES, MYOD1
48fibroma10.0VIM, DES
49myopathy10.0MYOD1, DES, MYOG
50spindle cell sarcoma10.0DES, VIM, S100B

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to embryonal sarcoma

Symptoms for Embryonal Sarcoma

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Drugs & Therapeutics for Embryonal Sarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Embryonal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Embryonal Sarcoma

Search NIH Clinical Center for Embryonal Sarcoma

Search CenterWatch for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

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Anatomical Context for Embryonal Sarcoma

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34MalaCards
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MalaCards organs/tissues related to Embryonal Sarcoma:

34
Liver, Kidney, Lung, Prostate, Brain, Heart, Smooth muscle, Adrenal gland

Animal Models for Embryonal Sarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Embryonal Sarcoma:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4GPC3, MDM2, KIT, TP53
2MP:00053818.9GPC3, MDM2, KIT, TP53, CDK4
3MP:00020068.9MYOD1, CDK4, MDM2, KIT, TP53
4MP:00053678.8CDK4, MDM2, KIT, TP53, GPC3
5MP:00107718.5GPC3, TP53, MYOG, CDK4, MDM2, KIT
6MP:00053908.4GPC3, MDM2, KIT, MYOG, MYOD1, TP53
7MP:00053808.4VIM, MYOG, CDK4, MDM2, KIT, TP53
8MP:00053888.3GPC3, KIT, MYOG, MYOD1, VIM, TP53
9MP:00053898.3VIM, TP53, MYOD1, KIT, MDM2, GPC3
10MP:00030128.1TP53, MALAT1, KIT, MDM2, MYOD1
11MP:00053858.1VIM, TP53, GPC3, DES, MDM2, CDK4
12MP:00053978.1SLPI, CDK4, MDM2, KIT, VIM, GPC3
13MP:00053878.0VIM, TP53, KIT, MDM2, CDK4, SLPI
14MP:00053698.0MYOD1, VIM, TP53, DES, MYOG, KIT
15MP:00028738.0S100B, KIT, MDM2, MYOG, MYOD1, TP53
16MP:00053847.8CDK4, TP53, GPC3, VIM, PEG3, KIT
17MP:00053867.4CDK4, PEG3, DES, VIM, MYOG, S100B
18MP:00053767.2DES, MYOD1, GPC3, TP53, VIM, MYOG
19MP:00053787.1VIM, MYOG, PEG3, GPC3, TP53, MYOD1
20MP:00107686.2MYOD1, VIM, TP53, GPC3, PEG3, DES

Publications for Embryonal Sarcoma

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53PubMed
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Articles related to Embryonal Sarcoma:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
2
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
3
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
4
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
5
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
6
Embryonal sarcoma of the liver in an adult patient. (22690347)
2012
7
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
8
A long-term survival case of adult undifferentiated embryonal sarcoma of liver. (22540346)
2012
9
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
10
Embryonal sarcoma of the liver in an adult mimicking complicated hepatic cyst: MRI findings. (20512902)
2010
11
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
12
A case of embryonal sarcoma of the liver. (21033305)
2010
13
Undifferentiated embryonal sarcoma: a case report. (20207789)
2010
14
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
15
Primary hepatic embryonal sarcoma masquerading as metastatic ovarian cancer. (19549298)
2009
16
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
17
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
18
Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. (17573940)
2007
19
Embryonal sarcoma of liver: an undifferentiated rare primary solid and mucoid to cystic tumour. (18306565)
2007
20
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
21
Pediatric and adult hepatic embryonal sarcoma: a comparative ultrastructural study with morphologic correlations. (17182431)
2006
22
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
23
Mutation of TP53 gene is involved in carcinogenesis of hepatic undifferentiated (embryonal) sarcoma of the adult, in contrast with Wnt or telomerase pathways: an immunohistochemical study of three cases with genomic relation in two cases. (15710230)
2005
24
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
25
Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy. (12673559)
2003
26
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
27
Cystic embryonal sarcoma of the kidney. (12394750)
2002
28
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
29
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
30
Cystic embryonal sarcoma of kidney: a case report. (9635536)
1998
31
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
32
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
33
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
34
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
35
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
36
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
37
Undifferentiated (embryonal) sarcoma arising in conjunction with mesenchymal hamartoma of the liver. (8066077)
1994
38
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
39
Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. (1727675)
1992
40
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
41
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
42
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
43
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
44
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
45
Undifferentiated (embryonal) sarcoma of the liver. (7395519)
1980
46
Embryonal sarcoma of the orbit. A clinical review of 19 Danish cases. (990019)
1976
47
A case of embryonal sarcoma (rhabdomyosarcoma) of the prostate treated with combined surgical and cytostatic therapy. (55104)
1975
48
Pulmonary blastoma (embryonal sarcoma of the lung). (4325327)
1971
49
Embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit. (4284785)
1965
50
Bilateral feline embryonal sarcoma. (13823299)
1960

Variations for Embryonal Sarcoma

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Expression for genes affiliated with Embryonal Sarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for genes affiliated with Embryonal Sarcoma

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 58SinoBiological, 31KEGG, 55R&D Systems, 61Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDK4, TP53
29.8TP53, MDM2
39.8TP53, MDM2
4
Show member pathways
9.8MDM2, TP53
5
Show member pathways
9.6TP53, MDM2, CDK4
69.6TP53, MDM2, CDK4
7
Show member pathways
Signaling Pathways in Glioblastoma39
9.6TP53, MDM2, CDK4
8
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.6TP53, MDM2, CDK4
99.6TP53, MDM2, CDK4
109.6TP53, MDM2, CDK4
119.6TP53, MDM2, CDK4
12
Show member pathways
Cell cycle39
9.6TP53, MDM2, CDK4
139.6MDM2, CDK4, TP53
149.6CDK4, MDM2, TP53
15
Show member pathways
9.6MDM2, CDK4, TP53
16
Show member pathways
9.6MDM2, TP53, CDK4
17
Show member pathways
9.6MDM2, CDK4, TP53
189.6CDK4, MDM2, TP53
199.6TP53, CDK4, MDM2
209.6MDM2, CDK4, TP53
21
Show member pathways
DNA damage response39
9.6CDK4, TP53, MDM2
229.5TP53, MDM2, GPC3
23
Show member pathways
9.5MYOG, MYOD1
24
Show member pathways
Signal transduction PTEN pathway61
9.5MDM2, TP53, KIT
259.5CDK4, VIM, TP53
269.4VIM, MDM2, TP53
279.2MDM2, CDK4, KIT, TP53
289.2TP53, MDM2, CDK4, KIT
29
Show member pathways
9.2KIT, MDM2, CDK4, TP53
30
Show member pathways
9.2CDK4, MDM2, TP53, MKI67
31
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.2VIM, CDK4, MDM2, TP53
32
Show member pathways
8.6MDM2, CDK4, TP53, KIT, VIM, DES

Compounds for genes affiliated with Embryonal Sarcoma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
See all sources

Compounds related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1orcein469.9DES, S100B, VIM
2s 100469.8DES, VIM, S100B
3flavopiridol46 1210.5TP53, KIT, MDM2, CDK4
4roscovitine469.5CDK4, VIM, MDM2, TP53
5gefitinib46 52 1211.4KIT, CDK4, MDM2, VIM
6valine469.3CDK4, MDM2, S100B, KIT, VIM
7toluidine469.2VIM, KIT, DES
8thymidylate469.2MDM2, VIM, TP53, MKI67, CDK4
9formaldehyde46 2510.2MKI67, DES, S100B, VIM, KIT
10vincristine46 52 1211.1MDM2, MKI67, TP53, VIM, KIT
11geldanamycin46 52 62 1212.1CDK4, MYOD1, TP53, MDM2, KIT
125fluorouracil469.1MKI67, KIT, MDM2, CDK4, TP53
13irinotecan46 52 1211.0TP53, KIT, MDM2, MKI67
14glycogen46 259.8DES, MKI67, VIM, S100B, KIT, MDM2
15iron46 259.7CDK4, MDM2, DES, SLPI, VIM, S100B
16tgf beta1468.7SLPI, VIM, MYOD1, CDK4, MKI67
17hematoxylin468.7KIT, S100B, VIM, SLPI, MKI67, DES
18estradiol46 25 1210.7DES, SLPI, VIM, MDM2, MKI67, CDK4
19proline468.7VIM, MDM2, MKI67, CDK4, S100B, DES
20doxorubicin46 52 1210.7MDM2, DES, MKI67, TP53, VIM, KIT
21paclitaxel46 52 1210.7MKI67, TP53, VIM, S100B, KIT, MDM2
2212-o-tetradecanoylphorbol 13-acetate468.6DES, CDK4, MYOG, MYOD1, VIM
23methionine468.6KIT, SLPI, S100B, VIM, DES
24ascorbic acid46 259.6SLPI, MKI67, CDK4, MYOG, S100B
25threonine468.5CDK4, DES, MKI67, MYOD1, S100B, KIT
26lactate468.5DES, VIM, S100B, KIT, SLPI, MKI67
27bromodeoxyuridine468.4MYOD1, DES, MKI67, VIM, CDK4, S100B
28progesterone46 30 62 25 1212.4CDK4, KIT, S100B, VIM, TP53, MKI67
29cyclic amp46 259.3DES, VIM, MYOD1, S100B, MDM2, CDK4
30cycloheximide468.3SLPI, MDM2, KIT, MKI67, TP53, CDK4
31butyrate468.2MYOD1, TP53, VIM, CDK4, SLPI, MYOG
325-aza-2deoxycytidine468.2MDM2, PEG3, GPC3, TP53, MYOD1, VIM
33arginine468.2MKI67, MDM2, S100B, MYOD1, VIM, CDK4
34thymidine46 259.2CDK4, DES, MKI67, TP53, S100B, KIT
35creatinine468.2MYOD1, DES, VIM, MYOG, SLPI, S100B
36actinomycin d468.1MYOD1, DES, VIM, SLPI, TP53, MDM2
37nitric oxide46 25 1210.1KIT, S100B, MYOG, MKI67, DES, MDM2
38oxygen46 258.9SLPI, MDM2, S100B, CDK4, MYOG, MYOD1
39glucose467.8MYOD1, MKI67, DES, S100B, KIT, CDK4
40steroid467.6CDK4, SLPI, DES, MDM2, KIT, S100B
41cysteine467.6SLPI, MDM2, DES, VIM, MYOD1, MYOG
42tyrosine467.5DES, S100B, MYOG, KIT, MDM2, CDK4
43paraffin467.5MDM2, KIT, S100B, MYOG, VIM, TP53
44oligonucleotide467.4GPC3, TP53, VIM, MYOD1, MYOG, KIT
45calcium46 52 25 1210.3DES, MYOG, CDK4, MDM2, KIT, S100B
46testosterone46 62 25 1210.2MKI67, VIM, MYOG, S100B, DES, KIT
47retinoic acid46 258.1TP53, MKI67, DES, MYOD1, MYOG, VIM
48estrogen466.8MKI67, TP53, SLPI, CDK4, KIT, S100B
49serine466.8TP53, S100B, SLPI, CDK4, MDM2, KIT
50vegf466.0SLPI, DES, PEG3, CDK4, MDM2, KIT

GO Terms for genes affiliated with Embryonal Sarcoma

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17Gene Ontology
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Cellular components related to Embryonal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.7MDM2, TP53
2transcription factor complexGO:0056679.0MYOD1, MYOG, CDK4
3nucleoplasmGO:0056548.6CDK4, MDM2, MYOG, MYOD1, TP53
4nucleusGO:0056347.1CDK4, MDM2, S100B, MYOG, MYOD1, TP53

Biological processes related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.1MDM2, CDK4
2cellular response to hypoxiaGO:0714569.7MDM2, S100B, TP53
3muscle cell fate commitmentGO:0426939.7MYOG, MYOD1
4positive regulation of cell cycle arrestGO:0711589.6MYOG, TP53
5skeletal muscle fiber developmentGO:0487419.6MYOD1, MYOG
6cellular response to estradiol stimulusGO:0713929.6MYOG, MYOD1
7positive regulation of cell proliferationGO:0082849.6S100B, KIT, MDM2, CDK4
8response to antibioticGO:0466779.5MDM2, TP53
9muscle cell differentiationGO:0426929.5MYOG, MYOD1
10positive regulation of muscle cell differentiationGO:0511499.4MYOD1, MYOG

Molecular functions related to Embryonal Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.9MDM2, VIM
2RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0012289.8TP53, MYOG
3chromatin DNA bindingGO:0314909.5MYOD1, MYOG
4ubiquitin protein ligase bindingGO:0316259.4MDM2, MYOD1, TP53
5E-box bindingGO:0708889.4MYOG, MYOD1
6core promoter bindingGO:0010479.2MYOG, MYOD1
7enzyme bindingGO:0198999.2SLPI, MDM2, TP53
8identical protein bindingGO:0428029.1DES, TP53, VIM, S100B, MDM2
9protein bindingGO:0055156.7SLPI, DES, MKI67, GPC3, TP53, VIM

Products for genes affiliated with Embryonal Sarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Embryonal Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet