MCID: EMP001
MIFTS: 43

Empty Sella Syndrome malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Empty Sella Syndrome

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Aliases & Descriptions for Empty Sella Syndrome:

Name: Empty Sella Syndrome 10 45 46 12 36 65
Empty Sella Turcica 45
 
Empty Sella 47

Classifications:



External Ids:

Disease Ontology10 DOID:3642
MeSH36 D004652
NCIt42 C84686
UMLS65 C0014008

Summaries for Empty Sella Syndrome

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NIH Rare Diseases:45 Empty sella syndrome (ess) is a condition that involves the sella turcica, a bony structure at the base of the brain that protects the pituitary gland. there is a primary and secondary form of the condition. the primary form occurs when a structural defect above the pituitary gland increases pressure in the sella turcica and causes the gland to flatten. the secondary form occurs when the pituitary gland is damaged due to injury, a tumor, surgery or radiation therapy. some people with ess have no symptoms. people with secondary ess may have symptoms of decreased pituitary function such as absence of menstruation, infertility, fatigue, and intolerance to stress and infection. in children, ess may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction. treatment focuses on the symptoms present in each person. last updated: 7/14/2014

MalaCards based summary: Empty Sella Syndrome, also known as empty sella turcica, is related to hypogonadism and headache, and has symptoms including pituitary enlargement An important gene associated with Empty Sella Syndrome is PRL (Prolactin), and among its related pathways are Signaling events mediated by PTP1B and Glucocorticoid receptor regulatory network. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are integument and endocrine/exocrine gland.

NINDS:46 Empty Sella Syndrome (ESS) is a disorder that involves the , a bony structure at the base of the brain that surrounds and protects the pituitary gland. ESS is often discovered during radiological imaging tests for pituitary disorders. ESS occurs n up to 25 percent of the population.An individual with ESS may have no symptoms or may have symptoms resulting from partial or complete loss of pituitary function (including headaches, low sex drive, and impotence).

Wikipedia:68 Empty sella syndrome (abbreviated ESS) is where the pituitary gland shrinks or becomes flattened,... more...

Related Diseases for Empty Sella Syndrome

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Diseases related to Empty Sella Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism30.4POMC, PRL
2headache30.1INS, PRL
3pituitary adenoma29.9POMC, PRL, TRH
4acromegaly29.2IGF1, POMC, PRL, TRH
5central retinal vein occlusion27.5IGF1, INS, POMC, PRL, TRH
6obesity27.5IGF1, INS, POMC, PRL, TRH
7pituitary deficiency due to empty sella turcica syndrome12.4
8pseudotumor cerebri10.8
9craniofacial anomalies and anterior segment dysgenesis syndrome10.4
10congenital coronary artery aneurysm10.3POMC, PRL
11cranial nerve disease10.3POMC, PRL
12hypothalamic neoplasm10.3POMC, PRL
13mixed ductal-endocrine carcinoma10.3POMC, PRL
14lipoadenoma10.3IGF1, PRL
15progeria-associated arthropathy10.3IGF1, PRL
16gerstmann syndrome10.3POMC, PRL
17nodular episcleritis10.3POMC, PRL
18cold-induced sweating syndrome 210.3POMC, PRL
19brain angioma10.3IGF1, POMC
20adrenal cortical adenocarcinoma10.3POMC, PRL
21peripheral nerve schwannoma10.3POMC, PRL
22retinitis pigmentosa 4610.3POMC, PRL
23pituitary adenoma, prolactin-secreting10.2IGF1, PRL
24generalized torsion dystonia10.2PRL, TRH
25fatal infantile encephalomyopathy10.2IGF1, POMC
26intracerebral cystic meningioma10.2IGF1, PRL
27acute sphenoidal sinusitis10.2IGF1, POMC
28adenoma10.2
29adrenal carcinoma10.2POMC, PRL
30acth deficiency10.2
31oculoglandular tularemia10.2IGF1, PRL
32allergic asthma10.2POMC, PRL
33disease of mental health10.2POMC, PRL
34hemangioma of spleen10.2IGF1, POMC
35blepharochalasis10.2IGF1, PRL
36isolated levocardia10.2IGF1, POMC
37gasserian ganglion meningioma10.2POMC, TRH
38hyperprolactinemia10.2
39hypopituitarism10.2
40diabetes insipidus10.2
41intracranial hypertension10.2
42hepatic flexure cancer10.2IGF1, POMC
43bipolar ll disorder10.1POMC, TRH
44atrial heart septal defect10.1IGF1, PRL
45pituitary apoplexy10.1
46amenorrhea10.1
47hypothyroidism10.1
48thyroiditis10.1
49precocious puberty10.1
50malignant hyperthermia10.1IGF1, POMC

Graphical network of the top 20 diseases related to Empty Sella Syndrome:



Diseases related to empty sella syndrome

Symptoms for Empty Sella Syndrome

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UMLS symptoms related to Empty Sella Syndrome:


pituitary enlargement

Drugs & Therapeutics for Empty Sella Syndrome

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Drugs for Empty Sella Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones11748

Interventional clinical trials:

idNameStatusNCT IDPhase
1Growth Hormone Deficiency and Empty Sella Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional StudyCompletedNCT02092779
2Da Vinci Transoral Robotic-assisted Surgery of Pituitary GlandNot yet recruitingNCT02743442

Search NIH Clinical Center for Empty Sella Syndrome


Cochrane evidence based reviews: empty sella syndrome

Genetic Tests for Empty Sella Syndrome

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Anatomical Context for Empty Sella Syndrome

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MalaCards organs/tissues related to Empty Sella Syndrome:

33
Pituitary, Brain, Testes, Heart, Lung, Monocytes, Myeloid

Animal Models for Empty Sella Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Empty Sella Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2IGF1, INS, POMC, PRL
2MP:00053797.8IGF1, INS, POMC, PRL, TRH
3MP:00053767.5IGF1, INS, POMC, PRL, TRH
4MP:00036317.2IGF1, INS, POMC, PRL, TRH

Publications for Empty Sella Syndrome

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Articles related to Empty Sella Syndrome:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Septal cartilage plug technique in spontaneous cerebrospinal fluid rhinorrhea postoperatively diagnosed with partial empty sella syndrome. (24911604)
2014
2
Partial empty sella syndrome: a case report and review. (24757313)
2014
3
Empty sella syndrome - beyond being an incidental finding. (23565413)
2012
4
Empty sella syndrome in thyroid cancer survivor. (21837937)
2011
5
Precocious puberty and empty sella syndrome in a girl cured of acute lymphoblastic leukemia. (22308868)
2011
6
Primary pituitary abscess followed by empty sella syndrome in an adolescent girl. (18953655)
2010
7
Diagnostic dilemmas in a patient with anaemia. Empty sella syndrome--a case report. (20806186)
2010
8
Endocrine disturbances in empty sella syndrome: case reports and review of literature. (15901528)
2005
9
Primary empty sella syndrome in a series of 142 patients. (16304986)
2005
10
Empty sella syndrome: incidental findings at computerised tomography. (12789130)
2001
11
Empty sella syndrome following pituitary apoplexy. (10819270)
2000
12
Empty sella syndrome: does it exist in children? (10584841)
1999
13
Empty sella syndrome. (23119635)
1999
14
Primary empty sella syndrome and central retinal vein occlusion. (7746642)
1995
15
Echographic and ophthalmodynamometric study in the empty sella syndrome. (8278157)
1993
16
Transsphenoidal extradural chiasmapexy in the management of the symptomatic primary empty sella syndrome. (8237166)
1993
17
Empty sella syndrome associated with partial hypopituitarism (visualized on MRI scan). (1429078)
1992
18
Can empty sella syndrome be mistaken for a progressive form of nonarteritic ischemic optic neuropathy? (2383186)
1990
19
Transsphenoidal chiasmopexy for long standing visual failure in the secondary empty sella syndrome. (3267311)
1988
20
Empty sella syndrome and pituitary apoplexy. (2896893)
1988
21
Antipituitary antibodies in patients with the primary empty sella syndrome. (3417843)
1988
22
Empty sella syndrome occurring with polyostotic fibrous dysplasia of the midface: report of a case. (3507319)
1987
23
Empty sella syndrome and growth deficiency in childhood. (3667334)
1987
24
Empty sella syndrome in an adolescent. (3700200)
1986
25
Empty sella syndrome caused by syphilitic arachnoiditis. (3951113)
1986
26
Empty sella syndrome. (6723249)
1984
27
Dissociation of serum prolactin response to sequential thyrotropin-releasing hormone and chlorpromazine stimulation in patients with primary empty sella syndrome. (6436062)
1984
28
The empty sella syndrome. (6575148)
1983
29
Empty sella syndrome with visual field disturbance. (6855016)
1983
30
Coexistent primary empty sella syndrome and hyperprolactinemia. Report of 11 cases. (6870411)
1983
31
Empty sella syndrome. (7338504)
1981
32
The primary empty sella syndrome. Diagnosis with metrizamide cisternography. (6895391)
1981
33
Primary empty sella syndrome and hypopituitarism associated with primary hypothyroidism. (6792264)
1981
34
Diagnosis of empty sella syndrome using Amipaque cisternography combined with computerized tomography. (7350285)
1980
35
Empty sella syndrome, pulsating exophthalmos, and calvarial bone defects in a case of neurofibroma. (6782020)
1980
36
Physiopathological aspects of the empty sella syndrome combined with prolactin hypersecretion. (7193954)
1980
37
Familial pseudotumor cerebri and the empty sella syndrome. (6927213)
1980
38
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
39
The primary Empty Sella Syndrome in Hawaii. (914514)
1977
40
Empty sella syndrome with neurofibromatosis. (411749)
1977
41
Primary empty sella syndrome with elevated serum prolactin. (561354)
1977
42
The primary empty sella syndrome: analysis of the clinical characteristics, radiographic features, pituitary function and cerebrospinal fluid adenohypophysial hormone concentrations. (851132)
1977
43
Amenorrhea-galactorrhea associated with the empty-sella syndrome. (560123)
1977
44
The primary empty sella syndrome in a child. (839337)
1977
45
The empty sella syndrome. (904521)
1977
46
Primary empty sella syndrome with visual field defects. (937363)
1976
47
The empty sella syndrome. (1013000)
1976
48
Does pseudotumor cerebri cause the empty sella syndrome? (1168876)
1975
49
The empty sella syndrome. Case report. (5457646)
1970
50

Variations for Empty Sella Syndrome

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Expression for genes affiliated with Empty Sella Syndrome

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Search GEO for disease gene expression data for Empty Sella Syndrome.

Pathways for genes affiliated with Empty Sella Syndrome

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GO Terms for genes affiliated with Empty Sella Syndrome

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Biological processes related to Empty Sella Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:00458219.8IGF1, INS
2positive regulation of glycogen biosynthetic processGO:00457259.7IGF1, INS
3positive regulation of MAPK cascadeGO:00434109.4IGF1, INS
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.4IGF1, INS
5regulation of multicellular organism growthGO:00400149.4IGF1, PRL
6positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4IGF1, INS
7positive regulation of cell growthGO:00303079.2IGF1, INS
8positive regulation of cell migrationGO:00303359.2IGF1, INS
9positive regulation of DNA replicationGO:00457409.1IGF1, INS
10female pregnancyGO:00075659.1IGF1, PRL
11cellular protein metabolic processGO:00442678.7IGF1, INS, PRL

Sources for Empty Sella Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet