MCID: EMP001
MIFTS: 40

Empty Sella Syndrome malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Empty Sella Syndrome

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Aliases & Descriptions for Empty Sella Syndrome:

Name: Empty Sella Syndrome 11 47 48 38 13 67
Empty Sella Turcica 47
 
Empty Sella 49

Classifications:



External Ids:

Disease Ontology11 DOID:3642
MeSH38 D004652
NCIt44 C84686

Summaries for Empty Sella Syndrome

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Wikipedia:70 Empty sella syndrome (abbreviated ESS) is where the pituitary gland shrinks or becomes flattened,... more...

MalaCards based summary: Empty Sella Syndrome, also known as empty sella turcica, is related to diabetes insipidus and central retinal vein occlusion, and has symptoms including pituitary enlargement An important gene associated with Empty Sella Syndrome is PRL (Prolactin), and among its related pathways are Growth hormone receptor signaling and Signaling events mediated by PTP1B. Affiliated tissues include pituitary, brain and thyroid, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

NINDS:48 Empty Sella Syndrome (ESS) is a disorder that involves the

Related Diseases for Empty Sella Syndrome

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Diseases related to Empty Sella Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus28.9GNRH1, INS, POMC, PRL
2central retinal vein occlusion28.0GH1, INS, POMC, PRL, TRH
3pituitary deficiency due to empty sella turcica syndrome12.3
4craniofacial anomalies and anterior segment dysgenesis syndrome11.2
5intracranial hypertension, idiopathic11.1
6lactic acidosis10.3POMC, PRL
7colloid carcinoma of the pancreas10.3POMC, PRL
8immune system organ benign neoplasm10.3POMC, PRL
9osseous heteroplasia, progressive10.3POMC, PRL
10cold-induced sweating syndrome 210.3POMC, PRL
11congenital epulis10.3POMC, PRL
12fumarate hydratase deficiency10.3GH1, PRL
13ovarian mucinous malignant adenofibroma10.3GH1, PRL
14acute myocarditis10.3POMC, PRL
15hemiplegia alterans10.3INS, PRL
16loeffler endocarditis10.3POMC, PRL
17nasopharyngeal disease10.2POMC, PRL
18paranasal sinus cancer, adult10.2INS, PRL
19postural hypotension10.2GH1, PRL
20autoimmune oophoritis10.2GH1, POMC
21aortic valve atresia10.2GH1, PRL
22benign eccrine breast spiradenoma10.2INS, POMC
23myoclonic cerebellar dyssynergia10.2POMC, PRL
2449, xxxxx10.2GH1, PRL
25scleredema adultorum10.2INS, PRL
26genetic lipodystrophy10.2PRL, TRH
27conjunctival vascular disease10.2INS, POMC
28malignant granular cell skin tumor10.1POMC, TRH
29neurilemmoma of the pleura10.1INS, POMC
30dysthymic disorder10.1INS, PRL
31adenoma10.1
32patellofemoral pain syndrome10.1INS, POMC
33central nervous system angiosarcoma10.1INS, POMC
34acromegaly10.1
35pituitary adenoma10.1
36hypopituitarism10.1
37chronic salpingo-oophoritis10.1POMC, PRL
38echolalia10.1PRL, TRH
39acth deficiency10.1
40chancroid10.1INS, POMC
41hypertelorism, preauricular sinus, punctal pits, and deafness10.1INS, TRH
42keratoacanthoma10.1INS, POMC
43hyperprolactinemia10.0
44intracranial hypertension10.0
45benign prostate phyllodes tumor10.0GNRH1, PRL
46pituitary apoplexy10.0
47amenorrhea10.0
48hypothyroidism10.0
49thyroiditis10.0
50precocious puberty10.0

Graphical network of the top 20 diseases related to Empty Sella Syndrome:



Diseases related to empty sella syndrome

Symptoms for Empty Sella Syndrome

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UMLS symptoms related to Empty Sella Syndrome:


pituitary enlargement

Drugs & Therapeutics for Empty Sella Syndrome

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Drugs for Empty Sella Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones, Hormone Substitutes, and Hormone Antagonists12767
2Hormones13979
3Hormone Antagonists12778

Interventional clinical trials:

idNameStatusNCT IDPhase
1Growth Hormone Deficiency and Empty Sella Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional StudyCompletedNCT02092779
2Da Vinci Transoral Robotic-assisted Surgery of Pituitary GlandRecruitingNCT02743442

Search NIH Clinical Center for Empty Sella Syndrome


Cochrane evidence based reviews: empty sella syndrome

Genetic Tests for Empty Sella Syndrome

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Anatomical Context for Empty Sella Syndrome

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MalaCards organs/tissues related to Empty Sella Syndrome:

35
Pituitary, Brain, Thyroid, Bone, Testes

Animal Models for Empty Sella Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Empty Sella Syndrome:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9GNRH1, INS, POMC, PRL
2MP:00053798.4GNRH1, INS, POMC, PRL, TRH
3MP:00036317.6GNRH1, INS, POMC, PRL, TRH

Publications for Empty Sella Syndrome

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Articles related to Empty Sella Syndrome:

(show top 50)    (show all 193)
idTitleAuthorsYear
1
VISUAL VIGNETTES-PERSISTENT HEADACHES WITH APPARENT EMPTY SELLA SYNDROME. (27967223)
2016
2
Ectopic Acromegaly Arising from a Pituitary Adenoma within the Bony Intersphenoid Septum of a Patient with Empty Sella Syndrome. (27468406)
2016
3
A Case Report of Late Onset Mania Caused by Hyponatremia in a Patient With Empty Sella Syndrome. (26871784)
2016
4
Partial empty sella syndrome: a case report and review. (24757313)
2014
5
Empty sella syndrome - beyond being an incidental finding. (23565413)
2012
6
Empty sella syndrome. (23304808)
2012
7
Empty sella syndrome in thyroid cancer survivor. (21837937)
2011
8
Diagnostic dilemmas in a patient with anaemia. Empty sella syndrome--a case report. (20806186)
2010
9
Transsphenoidal treatment of secondary empty sella syndrome using low field strength intraoperative MRI: case report. (21132613)
2010
10
Empty sella syndrome associated with a hyperfunctioning microadenoma invading the clivus. (18071980)
2007
11
Cardiac tamponade under thyroid hormone replacement therapy in a patient with empty sella syndrome. (17143379)
2006
12
Treatment of empty sella syndrome with ventriculoperitoneal shunt. (15749434)
2005
13
Empty sella syndrome in nevoid basal cell carcinoma syndrome. (10838118)
2000
14
Prader-Labhart-Willi syndrome with central precocious puberty and empty sella syndrome. (10591439)
1999
15
Adrenal adenocarcinoma and empty sella syndrome in a 37-year-old woman. (10533165)
1999
16
Two cases of empty sella syndrome with variable dexamethasone-suppressibility of ACTH and cortisol. (8930530)
1996
17
Transsphenoidal extradural chiasmapexy in the management of the symptomatic primary empty sella syndrome. (8237166)
1993
18
Primary empty sella syndrome and hypogonadotropic hypogonadism in young male patients. (1502422)
1992
19
Empty sella syndrome associated with diabetes insipidus: case report and review of the literature. (2671113)
1989
20
Transsphenoidal chiasmopexy for long standing visual failure in the secondary empty sella syndrome. (3267311)
1988
21
Antipituitary antibodies in patients with the primary empty sella syndrome. (3417843)
1988
22
Empty sella syndrome associated with central nervous system cysticercosis. (3154189)
1988
23
Primary empty sella syndrome and benign intracranial hypertension. (3948665)
1986
24
Headache and the primary empty sella syndrome. (3718697)
1986
25
Adipsic hypernatremia in a patient with pseudotumor cerebri and the primary empty sella syndrome. (4067208)
1985
26
Primary empty sella syndrome with panhypopituitarism in a child. (6543857)
1984
27
The empty sella syndrome. (6575148)
1983
28
Empty sella syndrome with visual field disturbance. (6855016)
1983
29
Coexistent primary empty sella syndrome and hyperprolactinemia. Report of 11 cases. (6870411)
1983
30
Intracranial pressure in patients with the empty sella syndrome without benign intracranial hypertension. (7086441)
1982
31
Empty sella syndrome. (7338504)
1981
32
The primary empty sella syndrome. Diagnosis with metrizamide cisternography. (6895391)
1981
33
Primary empty sella syndrome and hypopituitarism associated with primary hypothyroidism. (6792264)
1981
34
Blood-cerebrospinal fluid barrier for prolactin in empty sella syndrome. (7291947)
1981
35
A case of empty sella syndrome with sufficient hypophyseal function and normal pregnancy. (7250078)
1981
36
CSF circulation in subjects with the empty sella syndrome. (7254514)
1981
37
Familial pseudotumor cerebri and the empty sella syndrome. (6927213)
1980
38
Primary empty sella syndrome with CSF rhinorrhea. (7420665)
1980
39
The Empty Sella syndrome secondary to Rathke's cleft cyst. (7435283)
1980
40
Diagnosis of primary empty sella syndrome by computed tomography. (517991)
1979
41
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
42
The primary Empty Sella Syndrome in Hawaii. (914514)
1977
43
The primary empty sella syndrome: analysis of the clinical characteristics, radiographic features, pituitary function and cerebrospinal fluid adenohypophysial hormone concentrations. (851132)
1977
44
The primary empty sella syndrome in a child. (839337)
1977
45
The empty sella syndrome. (904521)
1977
46
Spontaneous fracture of the dorsum sellae associated with post-irradiation empty sella syndrome. (897994)
1977
47
Primary empty sella syndrome with visual field defects. (937363)
1976
48
The empty sella syndrome. (1013000)
1976
49
Empty sella syndrome secondary to intrasellar cyst in adolescence. (961646)
1976
50
Contiguous internal carotid arteries in empty sella syndrome. (935432)
1976

Variations for Empty Sella Syndrome

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Expression for genes affiliated with Empty Sella Syndrome

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Search GEO for disease gene expression data for Empty Sella Syndrome.

Pathways for genes affiliated with Empty Sella Syndrome

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Pathways related to Empty Sella Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6GH1, PRL
29.5INS, PRL
39.4POMC, PRL
4
Show member pathways
9.3POMC, TRH
59.1GH1, INS, PRL
6
Show member pathways
9.1GH1, INS, PRL
7
Show member pathways
8.9GH1, INS, POMC
8
Show member pathways
8.3GH1, GNRH1, INS, PRL
9
Show member pathways
7.6GH1, GNRH1, POMC, PRL, TRH
10
Show member pathways
7.1GH1, GNRH1, INS, POMC, PRL, TRH

GO Terms for genes affiliated with Empty Sella Syndrome

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Cellular components related to Empty Sella Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.9POMC, TRH
2secretory granule lumenGO:00347749.7INS, POMC
3extracellular spaceGO:00056158.1GH1, GNRH1, INS, POMC
4extracellular regionGO:00055766.8GH1, GNRH1, INS, POMC, PRL, TRH

Biological processes related to Empty Sella Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1glucose transportGO:001575810.0GH1, INS
2negative regulation of feeding behaviorGO:200025210.0INS, TRH
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.9GH1, PRL
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6GH1, INS
5positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5GH1, INS
6positive regulation of JAK-STAT cascadeGO:00464279.3GH1, PRL
7female pregnancyGO:00075659.1GNRH1, PRL
8cell-cell signalingGO:00072678.0GNRH1, INS, POMC, TRH

Molecular functions related to Empty Sella Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:000514810.1GH1, PRL
2neuropeptide hormone activityGO:00051849.3POMC, TRH
3hormone activityGO:00051797.6GH1, GNRH1, INS, POMC, PRL

Sources for Empty Sella Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet