MCID: EMP001
MIFTS: 42

Empty Sella Syndrome malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Empty Sella Syndrome

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Aliases & Descriptions for Empty Sella Syndrome:

Name: Empty Sella Syndrome 10 45 46 12 36 65
Empty Sella Turcica 45
 
Empty Sella 47

Classifications:



External Ids:

Disease Ontology10 DOID:3642
MeSH36 D004652
NCIt42 C84686
UMLS65 C0014008

Summaries for Empty Sella Syndrome

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NIH Rare Diseases:45 Empty sella syndrome (ess) is a condition that involves the sella turcica, a bony structure at the base of the brain that protects the pituitary gland. there is a primary and secondary form of the condition. the primary form occurs when a structural defect above the pituitary gland increases pressure in the sella turcica and causes the gland to flatten. the secondary form occurs when the pituitary gland is damaged due to injury, a tumor, surgery or radiation therapy. some people with ess have no symptoms. people with secondary ess may have symptoms of decreased pituitary function such as absence of menstruation, infertility, fatigue, and intolerance to stress and infection. in children, ess may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction. treatment focuses on the symptoms present in each person. last updated: 7/14/2014

MalaCards based summary: Empty Sella Syndrome, also known as empty sella turcica, is related to pulmonary embolism and obesity. An important gene associated with Empty Sella Syndrome is PRL (Prolactin), and among its related pathways are Signaling events mediated by PTP1B and Glucocorticoid receptor regulatory network. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are integument and endocrine/exocrine gland.

NINDS:46 Empty Sella Syndrome (ESS) is a disorder that involves the , a bony structure at the base of the brain that surrounds and protects the pituitary gland. ESS is often discovered during radiological imaging tests for pituitary disorders. ESS occurs n up to 25 percent of the population.An individual with ESS may have no symptoms or may have symptoms resulting from partial or complete loss of pituitary function (including headaches, low sex drive, and impotence).

Wikipedia:68 Empty sella syndrome (abbreviated ESS) is where the pituitary gland shrinks or becomes flattened,... more...

Related Diseases for Empty Sella Syndrome

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Graphical network of the top 20 diseases related to Empty Sella Syndrome:



Diseases related to empty sella syndrome

Symptoms for Empty Sella Syndrome

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Drugs & Therapeutics for Empty Sella Syndrome

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Drugs for Empty Sella Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones11748

Interventional clinical trials:

idNameStatusNCT IDPhase
1Growth Hormone Deficiency and Empty Sella Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional StudyCompletedNCT02092779
2Da Vinci Transoral Robotic-assisted Surgery of Pituitary GlandNot yet recruitingNCT02743442

Search NIH Clinical Center for Empty Sella Syndrome


Cochrane evidence based reviews: empty sella syndrome

Genetic Tests for Empty Sella Syndrome

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Anatomical Context for Empty Sella Syndrome

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MalaCards organs/tissues related to Empty Sella Syndrome:

33
Pituitary, Brain, Testes, Lung, Breast, Liver, Bone

Animal Models for Empty Sella Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Empty Sella Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2IGF1, INS, POMC, PRL
2MP:00053797.8IGF1, INS, POMC, PRL, TRH
3MP:00053767.5IGF1, INS, POMC, PRL, TRH
4MP:00036317.2IGF1, INS, POMC, PRL, TRH

Publications for Empty Sella Syndrome

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Articles related to Empty Sella Syndrome:

(show top 50)    (show all 187)
idTitleAuthorsYear
1
Propensity Score-Based Approaches to Confounding by Indication in Individual Patient Data Meta-Analysis: Non-Standardized Treatment for Multidrug Resistant Tuberculosis. (27022741)
2016
2
High-Dose Desflurane for Tocolysis During Intrapartum Myelomeningocele Repair in a Patient with Post-Adriamycin Cardiomyopathy. (27182782)
2016
3
Distress of ostracism: oxytocin receptor gene polymorphism confers sensitivity to social exclusion. (25564674)
2015
4
Identification of a major causative agent of human cercarial dermatitis, Trichobilharzia franki (MA1ller and Kimmig 1994), in southern England and its evolutionary relationships with other European populations. (24946974)
2014
5
Post-cardiac surgery thrombotic thrombocytopenic purpura with digital ischaemia. (23659403)
2013
6
Gestational diabetes: the silent epidemic. (24377123)
2013
7
Evaluation of Expression of Lipases and Phospholipases of Malassezia restricta in Patients with Seborrheic Dermatitis. (24003273)
2013
8
Atrioventricular node reentrant tachycardia in patients with congenitally corrected transposition of the great arteries and results of radiofrequency catheter ablation. (23159417)
2012
9
Processing speed and executive abilities in children with phenylketonuria. (22866986)
2012
10
Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo. (22908963)
2012
11
Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication: A case report and review of literature. (22375266)
2012
12
Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population. (22729917)
2012
13
FoxM1: a master regulator of tumor metastasis. (21712406)
2011
14
Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome. (20603623)
2011
15
Vertigo is associated with advanced degenerative changes in patients with cervical spondylosis. (21597927)
2011
16
Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration. (19435814)
2009
17
Polycystin-1 and -2 dosage regulates pressure sensing. (19879844)
2009
18
Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study. (19500428)
2009
19
Phosphorylation-dependent Lys63-linked polyubiquitination of Daxx is essential for sustained TNF-{alpha}-induced ASK1 activation. (19789334)
2009
20
Vascular contraction and preeclampsia: downregulation of the Angiotensin receptor 1 by hemopexin in vitro. (19414647)
2009
21
Tumour necrosis factor (TNF)-alpha primes murine neutrophils when triggered via formyl peptide receptor-related sequence 2, the murine orthologue of human formyl peptide receptor-like 1, through a process involving the type I TNF receptor and subcellular granule mobilization. (18710405)
2008
22
CD28 downregulation on CD4+ T cells is associated with age of kidney transplant recipient. (18346013)
2008
23
The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men. (18192542)
2008
24
The antigenic binding sites of autoantibodies to factor XII in patients with recurrent pregnancy losses. (18278180)
2008
25
Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma. (17660949)
2007
26
Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors. (17096850)
2006
27
Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population. (16358261)
2006
28
Seborrheic distributed papules with palmoplantar hyperkeratosis--quiz case. Diagnosis: Ichthyosis hystrix, Curth-Macklin type. (15967930)
2005
29
Periodic secretion of adrenocorticotropin in a patient with Cushing's disease manifested during pregnancy. (16006722)
2005
30
Ileostomy carcinomas a review: the latent risk after colectomy for ulcerative colitis and familial adenomatous polyposis. (16232232)
2005
31
Early but not lasting improvement of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease) after infliximab therapy: relationships with variations in cytokine levels in suction blister fluids. (16197383)
2005
32
Tritrichomonas foetus induces apoptotic cell death in bovine vaginal epithelial cells. (15213160)
2004
33
N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications. (12752494)
2003
34
Transcription factor REST dependent proteins are comparable between Down syndrome and control brains: challenging a hypothesis. (15068239)
2003
35
A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. (11292354)
2001
36
Eight novel mutations of the androgen receptor gene in patients with androgen insensitivity syndrome. (11587068)
2001
37
A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. (11500818)
2001
38
Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma. (9916806)
1999
39
Hepatic adenoma and focal nodular hyperplasia: MR findings with superparamagnetic iron oxide-enhanced MRI. (9559234)
1998
40
Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: an immunohistochemical analysis. (9083936)
1997
41
Branch retinal artery occlusion by diathermy of a persistent hyaloid artery. (9439377)
1997
42
Recurrent infection of continuous subcutaneous insulin infusion sites with Mycobacterium fortuitum. (8612446)
1995
43
Construction of a novel bifunctional biogenic amine receptor by two point mutations of the H2-histamine receptor. (8529106)
1995
44
Endobronchial leiomyoma. (8500802)
1993
45
Sequestration of amyloid beta-peptide. (8239272)
1993
46
IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM-rheumatoid factor production in patients with rheumatoid arthritis. (1379131)
1992
47
First genomic sequence of a human Ig variable lambda gene belonging to subgroup III. (2124677)
1990
48
Coccidiosis in swine. (3488114)
1986
49
Denture stomatitis. 3. Histopathology of trauma- and candida-induced inflammatory lesions of the palatal mucosa. (5275807)
1970
50

Variations for Empty Sella Syndrome

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Expression for genes affiliated with Empty Sella Syndrome

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Search GEO for disease gene expression data for Empty Sella Syndrome.

Pathways for genes affiliated with Empty Sella Syndrome

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GO Terms for genes affiliated with Empty Sella Syndrome

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Biological processes related to Empty Sella Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:00458219.8IGF1, INS
2positive regulation of glycogen biosynthetic processGO:00457259.7IGF1, INS
3positive regulation of MAPK cascadeGO:00434109.4IGF1, INS
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.4IGF1, INS
5regulation of multicellular organism growthGO:00400149.4IGF1, PRL
6positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4IGF1, INS
7positive regulation of cell growthGO:00303079.2IGF1, INS
8positive regulation of cell migrationGO:00303359.2IGF1, INS
9positive regulation of DNA replicationGO:00457409.1IGF1, INS
10female pregnancyGO:00075659.1IGF1, PRL
11cellular protein metabolic processGO:00442678.7IGF1, INS, PRL

Sources for Empty Sella Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet