MCID: ENM002
MIFTS: 26

Enamel Erosion malady

Categories: Oral diseases

Aliases & Classifications for Enamel Erosion

Aliases & Descriptions for Enamel Erosion:

Name: Enamel Erosion 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:2497
ICD9CM 35 521.31
UMLS 69 C1456161

Summaries for Enamel Erosion

MalaCards based summary : Enamel Erosion is related to eversion of lacrimal punctum and alzheimer's disease 13. An important gene associated with Enamel Erosion is GPI (Glucose-6-Phosphate Isomerase), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs sodium fluoride and Anti-Infective Agents have been mentioned in the context of this disorder.

Related Diseases for Enamel Erosion

Graphical network of the top 20 diseases related to Enamel Erosion:



Diseases related to Enamel Erosion

Symptoms & Phenotypes for Enamel Erosion

Drugs & Therapeutics for Enamel Erosion

Drugs for Enamel Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 3,Phase 2 7681-49-4
2 Anti-Infective Agents Phase 3,Phase 2
3 Anti-Infective Agents, Local Phase 3,Phase 2
4 Cariostatic Agents Phase 3,Phase 2
5 Fluorides Phase 3,Phase 2
6 Listerine Phase 3,Phase 2
7 Protective Agents Phase 3,Phase 2
8 Fluorophosphate Phase 3
9
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
10
Salicylic acid Approved, Vet_approved 69-72-7 338
11
Mepivacaine Approved, Vet_approved 96-88-8 4062
12 Calcium, Dietary
13 Caseins
14 Olaflur
15 Fluorides, Topical
16 Antifungal Agents
17 Dermatologic Agents
18 Keratolytic Agents
19 Anesthetics

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions Completed NCT01641237 Phase 3
2 Pilot Study Utilising an Impression Technique to Capture in Vivo Images of Teeth Completed NCT02676219 Phase 3
3 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2
4 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model Completed NCT00752089 Phase 2
5 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
6 In Vivo Investigation of Initial Stages of Enamel Erosion Completed NCT02533466
7 Impact of Milk on Erosion/Abrasion of Enamel and Dentin - an in Situ Study Completed NCT01566357
8 Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion Completed NCT01657903
9 Can Surface Roughness Predict Progression of Tooth Wear? Completed NCT03178968
10 Evaluation of a Low-fluoride Anticaries Toothpaste Completed NCT01094210
11 Clinical Comparison of Two Resin Composites on Diastema Closure and Reshaping at Four Years Completed NCT02893735
12 Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study Recruiting NCT02780973
13 Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion Recruiting NCT02087345
14 Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion Active, not recruiting NCT03112278
15 NCCL Direct Composite Restoration Performance With Self-Etch and Multimode Adhesives Active, not recruiting NCT02698371

Search NIH Clinical Center for Enamel Erosion

Genetic Tests for Enamel Erosion

Anatomical Context for Enamel Erosion

Publications for Enamel Erosion

Articles related to Enamel Erosion:

(show top 50) (show all 136)
id Title Authors Year
1
Toothpastes and enamel erosion/abrasion- impact of active ingredients and the particulate fraction. ( 27650640 )
2016
2
In vitro effect of low-fluoride toothpastes containing sodium trimetaphosphate on enamel erosion. ( 26964595 )
2016
3
A new hand-held optical reflectometer to measure enamel erosion: correlation with surface hardness and calcium release. ( 27121129 )
2016
4
In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion. ( 27020912 )
2016
5
Analysis of the Early Stages and Evolution of Dental Enamel Erosion. ( 27224566 )
2016
6
A simple, sensitive and non-destructive technique for characterizing bovine dental enamel erosion: attenuated total reflection Fourier transform infrared spectroscopy. ( 27025266 )
2016
7
Influence of Calcium Phosphate and Apatite Containing Products on Enamel Erosion. ( 27430013 )
2016
8
Combined Tin-Containing Fluoride Solution and CO2 Laser Treatment Reduces Enamel Erosion in vitro. ( 26418736 )
2015
9
In Vitro Effects of Resin Infiltration on Enamel Erosion Inhibition. ( 25587972 )
2015
10
Protective effect of casein phosphopeptide-amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies. ( 25917931 )
2015
11
COa88 laser emission modes to control enamel erosion. ( 25988247 )
2015
12
Sequence of stannous and sodium fluoride solutions to prevent enamel erosion. ( 26454222 )
2015
13
Effect of home-bleaching gels modified by calcium and/or fluoride and the application of nano-hydroxyapatite paste on in vitro enamel erosion susceptibility. ( 26083582 )
2015
14
Enamel erosion and mechanical tooth wear in medieval Icelanders. ( 26358010 )
2015
15
Effect of sodium fluoride and stannous chloride associated with Nd:YAG laser irradiation on the progression of enamel erosion. ( 26227298 )
2015
16
In vitro effect of calcium-containing prescription-strength fluoride toothpastes on bovine enamel erosion under hyposalivation-simulating conditions. ( 25864237 )
2015
17
In vitro effect of low-fluoride toothpastes containing sodium trimetaphosphate on enamel erosion. ( 26092765 )
2015
18
Effect of High-Fluoride Dentifrice on Enamel Erosion Adjacent to Restorations In Vitro. ( 26266646 )
2015
19
Protective effect of fluoride varnish and fluoride gel on enamel erosion: roughness, SEM-EDS, and A/-EDXRF studies. ( 25626779 )
2015
20
Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. ( 26435410 )
2015
21
Er:YAG laser irradiation to control the progression of enamel erosion: an in situ study. ( 24985348 )
2014
22
A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. ( 25147133 )
2014
23
Fluoride varnishes containing calcium glycerophosphate: fluoride uptake and the effect on in vitro enamel erosion. ( 25416637 )
2014
24
Measuring initial enamel erosion with quantitative light-induced fluorescence and optical coherence tomography: an in vitro validation study. ( 24481141 )
2014
25
Benefits of a dentifrice containing 8% arginine, calcium carbonate, and sodium monofluorophosphate on enamel erosion. ( 24933796 )
2014
26
Calcium lactate pre-rinse increased fluoride protection against enamel erosion in a randomized controlled in situ trial. ( 24582799 )
2014
27
Combined effect of a fluoride-, stannous- and chitosan-containing toothpaste and stannous-containing rinse on the prevention of initial enamel erosion-abrasion. ( 24440712 )
2014
28
Three-dimensional profilometric assessment of early enamel erosion simulating gastric regurgitation. ( 24995810 )
2014
29
The effect of saliva substitutes on enamel erosion in vitro. ( 24705070 )
2014
30
Enamel erosion and prevention efficacy characterized by confocal laser scanning microscope. ( 24706542 )
2014
31
Enamel erosion--advanced mineralisation technology. Guest foreword. ( 24993849 )
2014
32
In vitro assessment of artificial saliva formulations on initial enamel erosion remineralization. ( 24269764 )
2014
33
Sodium fluoride and casein phosphopeptide-amorphous calcium phosphate cream plus sodium fluoride efficacy in preventing enamel erosion in a simulated oral environment study model. ( 25307910 )
2014
34
The CPP-ACP relieved enamel erosion from a carbonated soft beverage: an in vitro AFM and XRD study. ( 24581849 )
2014
35
Potential of CO2 lasers (10.6 A/m) associated with fluorides in inhibiting human enamel erosion. ( 25337934 )
2014
36
Effect of fluoride gels supplemented with sodium trimetaphosphate on enamel erosion and abrasion: in vitro study. ( 24581857 )
2014
37
In vitro effect of calcium nanophosphate and high-concentrated fluoride agents on enamel erosion: an AFM study. ( 23782170 )
2013
38
Protective effect of CO2 laser (10.6 I1m) and fluoride on enamel erosion in vitro. ( 22370619 )
2013
39
Effect of fluoride varnish supplemented with sodium trimetaphosphate on enamel erosion and abrasion: an in situ/ex vivo study. ( 24095984 )
2013
40
Effect of fluoride varnish supplemented with sodium trimetaphosphate on enamel erosion and abrasion. ( 24640433 )
2013
41
Effect of acidic solution viscosity on enamel erosion. ( 23315475 )
2013
42
Inhibition of enamel erosion by stannous and fluoride containing rinsing solutions. ( 23519818 )
2013
43
Effect of pretreatment with an Er:YAG laser and fluoride on the prevention of dental enamel erosion. ( 24149579 )
2013
44
Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion. ( 24346043 )
2013
45
Inhibition of enamel erosion by stannous fluoride containing rinsing solutions. ( 23781557 )
2013
46
Effect of a common diet and regular beverage on enamel erosion in various temperatures: an in-vitro study. ( 24910648 )
2013
47
Enamel erosion depths measured on impressions by a white light interferometer. ( 22724578 )
2013
48
The effects of smoothies on enamel erosion: an in situ study. ( 23909804 )
2013
49
Measuring enamel erosion: a comparative study of contact profilometry, non-contact profilometry and confocal laser scanning microscopy. ( 24209832 )
2013
50
Preventive effect of different toothpastes on enamel erosion: AFM and SEM studies. ( 24374971 )
2013

Variations for Enamel Erosion

Expression for Enamel Erosion

Search GEO for disease gene expression data for Enamel Erosion.

Pathways for Enamel Erosion

Pathways related to Enamel Erosion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Enamel Erosion

Cellular components related to Enamel Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Enamel Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 MTF1 SMARCA2 SMARCA4
2 transcription from RNA polymerase II promoter GO:0006366 9.43 MTF1 SMARCA2 SMARCA4
3 negative regulation of cell growth GO:0030308 9.37 SMARCA2 SMARCA4
4 regulation of transcription from RNA polymerase II promoter GO:0006357 9.33 MTF1 SMARCA2 SMARCA4
5 chromatin remodeling GO:0006338 8.96 SMARCA2 SMARCA4
6 response to cadmium ion GO:0046686 8.62 GPI MTF1

Molecular functions related to Enamel Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 helicase activity GO:0004386 9.37 SMARCA2 SMARCA4
2 histone binding GO:0042393 9.32 SMARCA2 SMARCA4
3 RNA polymerase II transcription coactivator activity GO:0001105 9.26 SMARCA2 SMARCA4
4 DNA-dependent ATPase activity GO:0008094 9.16 SMARCA2 SMARCA4
5 transcription coactivator activity GO:0003713 9.13 MTF1 SMARCA2 SMARCA4
6 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Enamel Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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