Aliases & Classifications for Enamel Erosion

MalaCards integrated aliases for Enamel Erosion:

Name: Enamel Erosion 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:2497
ICD9CM 34 521.31
UMLS 69 C1456161

Summaries for Enamel Erosion

MalaCards based summary : Enamel Erosion is related to dentine erosion and alpha thalassemia-x-linked intellectual disability syndrome. An important gene associated with Enamel Erosion is GPI (Glucose-6-Phosphate Isomerase), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs sodium fluoride and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes.

Related Diseases for Enamel Erosion

Graphical network of the top 20 diseases related to Enamel Erosion:



Diseases related to Enamel Erosion

Symptoms & Phenotypes for Enamel Erosion

Drugs & Therapeutics for Enamel Erosion

Drugs for Enamel Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 3,Phase 2 7681-49-4
2 Anti-Infective Agents Phase 3,Phase 2
3 Anti-Infective Agents, Local Phase 3,Phase 2
4 Cariostatic Agents Phase 3,Phase 2
5 Fluorides Phase 3,Phase 2
6 Listerine Phase 3,Phase 2
7 Protective Agents Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions Completed NCT01641237 Phase 3 sodium fluoride;no added fluoride in a silica base
2 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
3 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
4 In Vivo Investigation of Initial Stages of Enamel Erosion Completed NCT02533466

Search NIH Clinical Center for Enamel Erosion

Genetic Tests for Enamel Erosion

Anatomical Context for Enamel Erosion

MalaCards organs/tissues related to Enamel Erosion:

38
Testes

Publications for Enamel Erosion

Articles related to Enamel Erosion:

(show top 50) (show all 153)
# Title Authors Year
1
ATR-FTIR spectroscopy and I1-EDXRF spectrometry monitoring of enamel erosion caused by medicaments used in the treatment of respiratory diseases. ( 29134721 )
2018
2
Fluoride toothpastes containing micrometric or nano-sized sodium trimetaphosphate reduce enamel erosion in vitro. ( 29037096 )
2018
3
Effect of Mouthrinses containing Olive Oil, Fluoride, and Their Combination on Enamel Erosion: An in vitro Study. ( 29422460 )
2018
4
Nd:YAG laser irradiation associated with fluoridated gels containing photo absorbers in the prevention of enamel erosion. ( 28500516 )
2017
5
Frequency of Application of AmF/NaF/SnCl2 Solution and Its Potential in Controlling Human Enamel Erosion Progression: An in situ Study. ( 28125809 )
2017
6
Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo. ( 28637033 )
2017
7
In situ evaluation of fluoride-, stannous- and polyphosphate-containing solutions against enamel erosion. ( 28552363 )
2017
8
AmF/NaF/SnCl2 solution reduces in situ enamel erosion - profilometry and cross-sectional nanoindentation analysis. ( 28273206 )
2017
9
Remineralizing effect of a zinc-hydroxyapatite toothpaste on enamel erosion caused by soft drinks: Ultrastructural analysis. ( 28828151 )
2017
10
In vitro enamel erosion and abrasion-inhibiting effect of different fluoride varnishes. ( 28167334 )
2017
11
A novel approach to study in situ enamel erosion and abrasion lesions. ( 28232081 )
2017
12
A New Laser-Processing Strategy for Improving Enamel Erosion Resistance. ( 28665779 )
2017
13
Effects of tannin-fluoride and milk-fluoride mixture on human enamel erosion from inappropriately chlorinated pool water. ( 28904314 )
2017
14
Effect of Fluoride Varnish Containing CPP-ACP on Preventing Enamel Erosion. ( 29109803 )
2017
15
Effect of CPP-ACP or a Potassium Nitrate Sodium Fluoride Dentifrice on Enamel Erosion Prevention. ( 28288296 )
2017
16
Protective effect of zinc-hydroxyapatite toothpastes on enamel erosion: An in vitro study. ( 28149475 )
2017
17
A new hand-held optical reflectometer to measure enamel erosion: correlation with surface hardness and calcium release. ( 27121129 )
2016
18
Protective effects of a zinc-hydroxyapatite toothpaste on enamel erosion: SEM study. ( 28149449 )
2016
19
Toothpastes and enamel erosion/abrasion- impact of active ingredients and the particulate fraction. ( 27650640 )
2016
20
In vitro effect of low-fluoride toothpastes containing sodium trimetaphosphate on enamel erosion. ( 26964595 )
2016
21
Influence of Calcium Phosphate and Apatite Containing Products on Enamel Erosion. ( 27430013 )
2016
22
In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion. ( 27020912 )
2016
23
Analysis of the Early Stages and Evolution of Dental Enamel Erosion. ( 27224566 )
2016
24
A simple, sensitive and non-destructive technique for characterizing bovine dental enamel erosion: attenuated total reflection Fourier transform infrared spectroscopy. ( 27025266 )
2016
25
Protective effect of casein phosphopeptide-amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies. ( 25917931 )
2015
26
In vitro effect of calcium-containing prescription-strength fluoride toothpastes on bovine enamel erosion under hyposalivation-simulating conditions. ( 25864237 )
2015
27
Effect of home-bleaching gels modified by calcium and/or fluoride and the application of nano-hydroxyapatite paste on in vitro enamel erosion susceptibility. ( 26083582 )
2015
28
Enamel erosion and mechanical tooth wear in medieval Icelanders. ( 26358010 )
2015
29
Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. ( 26435410 )
2015
30
COa88 laser emission modes to control enamel erosion. ( 25988247 )
2015
31
Combined Tin-Containing Fluoride Solution and CO2 Laser Treatment Reduces Enamel Erosion in vitro. ( 26418736 )
2015
32
In vitro effect of low-fluoride toothpastes containing sodium trimetaphosphate on enamel erosion. ( 26092765 )
2015
33
Effect of sodium fluoride and stannous chloride associated with Nd:YAG laser irradiation on the progression of enamel erosion. ( 26227298 )
2015
34
In Vitro Effects of Resin Infiltration on Enamel Erosion Inhibition. ( 25587972 )
2015
35
Protective effect of fluoride varnish and fluoride gel on enamel erosion: roughness, SEM-EDS, and A/-EDXRF studies. ( 25626779 )
2015
36
Sequence of stannous and sodium fluoride solutions to prevent enamel erosion. ( 26454222 )
2015
37
Effect of High-Fluoride Dentifrice on Enamel Erosion Adjacent to Restorations In Vitro. ( 26266646 )
2015
38
Measuring initial enamel erosion with quantitative light-induced fluorescence and optical coherence tomography: an in vitro validation study. ( 24481141 )
2014
39
The effect of saliva substitutes on enamel erosion in vitro. ( 24705070 )
2014
40
Combined effect of a fluoride-, stannous- and chitosan-containing toothpaste and stannous-containing rinse on the prevention of initial enamel erosion-abrasion. ( 24440712 )
2014
41
Er:YAG laser irradiation to control the progression of enamel erosion: an in situ study. ( 24985348 )
2014
42
Benefits of a dentifrice containing 8% arginine, calcium carbonate, and sodium monofluorophosphate on enamel erosion. ( 24933796 )
2014
43
Fluoride varnishes containing calcium glycerophosphate: fluoride uptake and the effect on in vitro enamel erosion. ( 25416637 )
2014
44
Calcium lactate pre-rinse increased fluoride protection against enamel erosion in a randomized controlled in situ trial. ( 24582799 )
2014
45
Potential of CO2 lasers (10.6 A/m) associated with fluorides in inhibiting human enamel erosion. ( 25337934 )
2014
46
A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. ( 25147133 )
2014
47
Effect of fluoride gels supplemented with sodium trimetaphosphate on enamel erosion and abrasion: in vitro study. ( 24581857 )
2014
48
Enamel erosion and prevention efficacy characterized by confocal laser scanning microscope. ( 24706542 )
2014
49
Enamel erosion--advanced mineralisation technology. Guest foreword. ( 24993849 )
2014
50
The CPP-ACP relieved enamel erosion from a carbonated soft beverage: an in vitro AFM and XRD study. ( 24581849 )
2014

Variations for Enamel Erosion

Expression for Enamel Erosion

Search GEO for disease gene expression data for Enamel Erosion.

Pathways for Enamel Erosion

Pathways related to Enamel Erosion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Enamel Erosion

Cellular components related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.5 MTF1 SMARCA2 SMARCA4
2 chromatin remodeling GO:0006338 9.26 SMARCA2 SMARCA4
3 response to cadmium ion GO:0046686 9.16 GPI MTF1
4 ATP-dependent chromatin remodeling GO:0043044 8.96 SMARCA2 SMARCA4
5 transcription by RNA polymerase II GO:0006366 8.92 MTF1 NCBP1 SMARCA2 SMARCA4

Molecular functions related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription coactivator activity GO:0001105 9.26 SMARCA2 SMARCA4
2 DNA-dependent ATPase activity GO:0008094 9.16 SMARCA2 SMARCA4
3 transcription coactivator activity GO:0003713 9.13 MTF1 SMARCA2 SMARCA4
4 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Enamel Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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