Encephalitis malady

NINDS: Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.³¹

MalaCards: Encephalitis is related to japanese encephalitis and tick-borne encephalitis. An important gene associated with Encephalitis is TREX1 (three prime repair exonuclease 1), and among its related pathways are Measles and Immune System. The compounds nitric oxide and cysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are vision/eye and endocrine/exocrine gland.

Disease Ontology: Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures.⁶

MedlinePlus: Encephalitis is an inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache sudden fever drowsiness vomiting confusion seizures for mild cases, you may just need rest, plenty of fluids and a pain reliever. for severe cases, you might need to be hospitalized. fortunately, encephalitis is uncommon in the united states. nih: national institute of neurological disorders and stroke²³

Wikipedia: Encephalitis is an acute inflammation of the brain. Encephalitis with meningitis is known as...⁴⁴ more...

Aliases & Descriptions:

encephalitis 6 31 8 32 23 43

Diseases related to encephalitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 959)

id	Related Disease	Score	Top Affiliating Genes
1	japanese encephalitis	40.0	SENP8, RAF1, FUBP1, JUN, CD40LG, IVNS1ABP
2	tick-borne encephalitis	39.7	ZNF354B, RAF1, SCRIB, SAT1, B2M, IVNS1ABP
3	limbic encephalitis	36.8	SH2D1A, BRSK2, LGI1, GSR, GRIA1, GRIN2B
4	venezuelan equine encephalitis	36.2	SH2D3A, SH2D3C, RAB5A, RAB7A, BCAR3, LGALS3
5	viral encephalitis	35.7	VCAM1, MX1, MBP, ADA
6	rasmussen encephalitis	35.0	BMP6, SCN1A, SCN2B, CHRNA7, GZMB, GSR
7	herpes simplex	34.5	PIK3CG, REV3L, VEGFA, MYD88, RAF1, BDNF
8	immunodeficiency	34.3	MYD88, BMP6, CIITA, MOG, CD79A, CD4
9	herpes simplex encephalitis	34.1	UNC93B1, S100B, IL2RB, APOE, ELANE, TLR3
10	west nile virus	33.9	RAB5A, SCN1A, MX1, CD40LG, IVNS1ABP, IL1B
11	eastern equine encephalitis	33.8	SH2D3C, CLNK, MT-CYB, IFNA1, IFNG, EXOC7
12	la crosse encephalitis	33.3	PAK6, CD40LG, HUWE1, STAB2, PRNT, POLR2A
13	meningitis	33.1	ZNF32, PIK3CG, SELE, VEGFA, MYD88, BMP6
14	meningitis and encephalitis	32.9	CAT, NTF3, NTF4, CRP, SOD1, GDNF
15	murray valley encephalitis	32.7	RAF1, IFT81, HRSP12, PPP1R14B, KRAS, STRBP
16	encephalomyelitis	32.5	CNP, CNR1, CNTF, VEGFA, VCAM1, BMP6
17	granulomatous amebic encephalitis	32.4	ENTPD2, GMPPB, HM13, PDE8A
18	st. louis encephalitis	32.3	RAF1, CD40LG, GPR162, IFNA8, NRCAM
19	west nile encephalitis	32.2	BST2, ITPRIP, INVS, IL12A, OAS1, OAS2
20	arthritis	32.1	FGF1, IL17A, IL1B, IL6, TNF, TNFRSF1A
21	aicardi-goutieres syndrome	32.0	SCN1A, CD4, ITIH4, AQP4, APP, MBP
22	western equine encephalitis	31.9	SH2D3C, CLNK, FANCL, ERF, NTSR1, STAB2
23	subacute sclerosing panencephalitis	31.3	MX1, S100B, MOG, CD46, IL10, IL12B
24	acquired immunodeficiency syndrome	31.3	RAF1, CIITA, MT-CYB, S100B, B2M, CD4
25	multiple sclerosis	30.7	MOG, IL12A, IL1B, APOE, MBP, CCR5
26	hepatitis	30.6	GZMB, GSR, IL2RB, GPT, IFNA1, IFNB1
27	neurologic diseases	30.3	SH2D1A, CNTF, CHI3L1, B2M, MOG, CD9
28	rabies	30.2	VEGFA, BCL2, CHI3L1, MX1, CD274, ITIH4
29	bacterial meningitis	30.2	IL1B, CCL4, CCL3, CRP, TLR2, C5AR1
30	meningoencephalitis	30.0	B2M, CD79A, CD4, CD40LG, IL6, APP
31	neuronitis	29.9	PIK3CG, SH2D1A, CNP, CNR1, CNR2, CNTF
32	measles	29.8	PIK3CG, SH2D1A, SELE, VCAM1, MYD88, CIITA
33	trypanosomiasis	29.7	PIK3CG, SELE, VCAM1, MYD88, BMP6, JUN
34	parkinson's disease	29.3	CNR1, CNTF, PAWR, BDNF, CIITA, CHRNA7
35	cerebral malaria	29.2	SELE, VCAM1, IL10, IL12B, IL1B, IFNG
36	adrenoleukodystrophy	29.2	S100B, MOG, IL1B, IL4, IL6, MBP
37	neurodegeneration	28.9	PIK3CG, CNR1, CNR2, CNTF, VEGFA, BMP6
38	teratoma	28.8	BCL2, JUN, GSR, GRN, ENO2, ERVK-6
39	acute disseminated encephalomyelitis	28.6	CNTF, MOG, IL10, AQP4, MBP, HLA-DQB1
40	viral meningitis	28.5	IL16, IL6, CCL5, NTF3, CRP, CXCR3
41	diabetes insipidus	28.4	S100B, AVP, AQP4, TPO, CRP, ACP1
42	lyme disease	28.2	CIITA, CD40LG, IL17A, IL1B, IL6, MBP
43	paraneoplastic syndromes	28.1	CD79A, GSR, IL5, IL6, ENO2, AMPH
44	febrile seizures	28.1	CNR1, BDNF, SCN1A, LGI1, IL10, IL1B
45	temporal lobe epilepsy	28.1	BDNF, LGI1, GRIN2B, AQP4, CALB1, NTF3
46	thymoma	28.1	RAF1, BCL2, KCNH2, B2M, CD8A, CD4
47	hepatic encephalopathy	28.0	S100B, IL18, IL6, AQP4, GPT, ALB
48	hepatitis c	27.9	CIITA, MX1, JUN, CD40LG, GSR, IL10
49	hepatitis a	27.5	MX1, B2M, CD79A, CD4, CD40LG, IL10
50	chronic fatigue syndrome	27.2	B2M, CD4, GSR, IL10, IL2RB, IL4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to encephalitis:

²²

MGI Mouse Phenotypes related to encephalitis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye phenotype	MP:0005391	INF	CNP, CNTN1, SELE, VEGFA, MYD88, RAF1
2	endocrine/exocrine gland phenotype	MP:0005379	11.4	CNP, SCRIB, CD40LG, IL2RB, FANCL, IFNG
3	skeleton phenotype	MP:0005390	10.9	PIK3CG, CNP, CNR1, VEGFA, MYD88, BMP6
4	reproductive system phenotype	MP:0005389	10.8	SH2D3C, CNP, VEGFA, BECN1, PAK6, SCRIB
5	respiratory system phenotype	MP:0005388	10.8	CNP, BDNF, SCRIB, CHRNA7, CDK5, IVNS1ABP
6	liver/biliary system phenotype	MP:0005370	10.1	VEGFA, UNC93B1, SAT1, FURIN, ITIH4, FLNA
7	hematopoietic system phenotype	MP:0005397	10.0	SH2D1A, SH2D3C, REV3L, CNTF, BST2, MYD88
8	normal phenotype	MP:0002873	10.0	SELE, BRSK2, VEGFA, PAWR, PAK6, BDNF
9	renal/urinary system phenotype	MP:0005367	9.8	MYD88, BCL2, UNC93B1, AVP, INVS, AQP4
10	immune system phenotype	MP:0005387	9.8	SH2D1A, SH2D3C, REV3L, CNP, CNR2, CNTF
11	digestive/alimentary phenotype	MP:0005381	9.6	CNP, VEGFA, BDNF, BCL2, SCRIB, LGALS3
12	muscle phenotype	MP:0005369	9.5	PIK3CG, CNP, CNTF, CNTN1, VEGFA, RAF1
13	no phenotypic analysis	MP:0003012	9.3	SH2D3C, CNR1, BST2, VEGFA, VCAM1, MYD88
14	behavior/neurological phenotype	MP:0005386	9.0	SH2D3C, CNP, CNR1, CNTF, CNTN1, CNTNAP2
15	adipose tissue phenotype	MP:0005375	8.4	CNR1, MYD88, BCL2, LGI1, SAT1, IL18
16	integument phenotype	MP:0010771	7.8	PIK3CG, CNR1, CNR2, CNTNAP2, BRSK2, RAF1
17	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, REV3L, SELE, VEGFA, VCAM1, MYD88
18	mortality/aging	MP:0010768	INF	SH2D3C, REV3L, CNP, CNR1, CNTN1, SELE
19	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CG, REV3L, CNP, CNR1, CNTF, SELE
20	cellular phenotype	MP:0005384	INF	PIK3CG, SH2D1A, SH2D3C, REV3L, CNR1, CNTF
21	growth/size phenotype	MP:0005378	INF	PIK3CG, REV3L, CNP, CNR1, CNTN1, CNTNAP2
22	tumorigenesis	MP:0002006	INF	REV3L, MYD88, BECN1, BCL2, BCL2L1, SCRIB
23	embryogenesis phenotype	MP:0005380	INF	REV3L, RAF1, BECN1, KCNH2, SCRIB, FURIN
24	nervous system phenotype	MP:0003631	INF	SH2D3C, REV3L, CNP, CNR1, CNTF, CNTN1
25	craniofacial phenotype	MP:0005382	INF	REV3L, BDNF, KCNH2, ITGA4, , FLNA

Articles related to encephalitis:

(show top 50)    (show all 243)

id	Title	Authors	Year	Affiliating Genes
1	Cannabinoid receptor expression in HIV encephalitis a nd HIV-associated neuropathologic comorbidities. (21450051)	Cosenza-Nashat M.A.... Lee S.C.	2011	CNR1, CNR2
2	MYBPC1 computational phosphoprotein network construct ion and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-con trol patients. (21061152)	Wang L.... Sun L.	2011	MYBPC1
3	T cell factor-1 negatively regulates expression of IL -17 family of cytokines and protects mice from experimental autoimmune encephal omyelitis. (21339363)	Yu Q.... Sen J.M.	2011	TCF7
4	A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection. (21216866)	Kindberg E.... Svensson L.	2011	TLR3
5	La protein can simultaneously bind to both 3'- and 5' -noncoding regions of Japanese encephalitis virus genome. (21294637)	Vashist S.... Vrati S.	2011	SSB
6	Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat mod el of Parkinson's disease induced by Japanese encephalitis virus. (19879254)	Hamaue N.... Aoki T.	2010	COMT
7	Variability in the 2'-5'-oligoadenylate synthetase ge ne cluster is associated with human predisposition to tick-borne encephalitis v irus-induced disease. (21050126)	Barkhash A.V.... Brinton M.A.	2010	OAS1, OAS2, OAS3
8	C-terminal fragment of human laminin-binding protein contains a receptor domain for venezuelan equine encephalitis and tick-borne en cephalitis viruses. (19961413)	Malygin A.A.... Loktev V.B.	2009	LGALS3, RPSA
9	Alpha interferon as an adenovirus-vectored vaccine adjuvant and antiviral in Venezuelan equine encephalitis virus infection. (19264673)	O'Brien L.... Phillpotts R.	2009	IFNA1
10	AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. (19338055)	Lai M.... Dalmau J.	2009	GRIA1
11	Possible congenital infection with La Crosse encephal itis virus--West Virginia, 2006-2007. (19145220)		2009	CD40LG
12	Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis. (18046731)	Gorantla S.... Gendelman H.E.	2008	IL10
13	The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. (18768981)	Chan Y.L.... Lin Y.L.	2008	RSAD2
14	Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling. (18042258)	Werme K.... Johansson M.	2008	SCRIB
15	Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice. (18842892)	Do Carmo S.... Rassart E.	2008	APOD
16	Peroxisome proliferator-activated receptor-gamma activation suppresses HIV-1 replication in an animal model of encephalitis. (18670212)	Potula R.... Persidsky Y.	2008	PPARG
17	CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis. (18678898)	McCandless E.E.... Klein R.S.	2008	CXCR4
18	Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression. (17267491)	Aguilar P.V.... Basler C.F.	2007	IFNA1
19	TLR3 deficiency in patients with herpes simplex encephalitis. (17872438)	Zhang S.-Y.... Casanova J.-L.	2007	TLR3
20	Cerebrospinal fluid-infiltrating CD4+ T cells recogni ze Borrelia burgdorferi lysine-enriched protein domains and central nervous sys tem autoantigens in early lyme encephalitis. (17060473)	LA1nemann J.D.... Martin R.	2007	CNP
21	Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor. (17603244)	Okamoto S.... Uchino M.	2007	GSR
22	Elevated concentration of the chemokine CCL3 (MIP-1alpha) in cerebrospinal fluid and serum of patients with tick borne encephalitis. (17357337)	Grygorczuk S.... Hermanowska-Szpakowicz T.	2006	CCL3
23	Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)	Ances B.M.... Dalmau J.	2005	PPP1R9B
24	HLA class II involvement in HIV-associated Toxoplasmic encephalitis development. (15885635)	Habegger de Sorrentino A.... Salomon H.	2005	HLA-DQB1, HLA-DRB1
25	Antibodies to DNA in the blood of patients with tick -borne encephalitis (15456145)	Garmashova N.V.... NevinskiA- G.A.	2004	GPT
26	Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. (15079019)	Thieben M.J.... Vernino S.	2004	TPO, GAD2
27	Non-herpetic acute limbic encephalitis: cerebrospinal fluid cytokines and magnetic resonance imaging findings. (14964578)	Asaoka K.... Eizuru Y.	2004	IL6, IFNG
28	Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. (14739339)	Kurt-Jones E.A.... Finberg R.W.	2004	CCL2
29	Altered P-glycoprotein expression in AIDS patients with HIV encephalitis. (15535131)	Langford D.... Masliah E.	2004	ABCB1
30	Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. (14997933)	Ferrer I.... Costa-JussA! F.	2004	APP
31	Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus (12708317)	Gavrilov B.G.... Sverdlov E.D.	2003	IFIT2, IFIT1
32	Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. (12594292)	Boven L.A.... Power C.	2003	F2R
33	Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses. (12083816)	Nikiforova N.N.... Sverdlov E.D.	2002	SAT1
34	Cell cycle proteins exhibit altered expression patter ns in lentiviral-associated encephalitis. (11896158)	Jordan-Sciutto K.L.... Wiley C.A.	2002	E2F1
35	Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. (11574916)	Zink M.C.... Clements J.E.	2001	CCL2
36	Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. (10595922)	Dallasta L.M.... Achim C.L.	1999	TJP1
37	Time course of chemokines in the cerebrospinal fluid and serum during herpes simplex type 1 encephalitis. (9600681)	RAPsler A.... Sprenger H.	1998	CCL3
38	Neurodegeneration of somatostatin-immunoreactive neur ons in HIV encephalitis. (9100666)	Fox L.... Masliah E.	1997	SST
39	Proinflammatory cytokine levels in cerebrospinal fluid from children with acute encephalitis (9394601)	Ichiyama T.... Furukawa S.	1997	IL1B
40	Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages. (9311828)	Lechner F.... Peterhans E.	1997	IL12B
41	Blood levels of protein markers of inflammation and nutrition in the meningo-encephalitis phase of human African trypanosomiasis (9289245)	Monnet D.... Yapo A.E.	1997	TF
42	Secretion of tick-borne encephalitis virus glycoproteins E and NS1 heterocomplex in the late stage of infection (9304300)	Matveeva V.A.... Morozova O.V.	1997	IVNS1ABP
43	Accumulation of beta-amyloid precursor protein in HIV encephalitis: relationship with neuropsychological abnormalities. (9225683)	Giometto B.... Scaravilli F.	1997	APP, RPS27A
44	Major histocompatibility complex class I expression on neurons in subacute sclerosing panencephalitis and experimental subacute measles encephalitis. (8786403)	Gogate N.... Dhib-Jalbut S.	1996	HLA-B
45	Up-regulation of major histocompatibility complex class II antigen expression in the central nervous system of dogs with spontaneous canine distemper virus encephalitis. (8870829)	Alldinger S.... Kremmer E.	1996	CIITA
46	Chronic steroid-responsive encephalitis without autoantibodies to glutamate receptor GluR3. (8559386)	Krauss G.L.... Niedermeyer E.	1996	GRIA3
47	Hyperfixation of 99mTc-HMPAO and hypofixation of 123I-iomazenil in acute herpes encephalitis. (7662908)	Launes J.... Iivanainen M.	1995	TSPO
48	Human cerebral cortical cell lines from patients with unilateral megalencephaly and Rasmussen's encephalitis. (7700510)	Ronnett G.V.... Snyder S.H.	1994	SST, CCK
49	Cytokines and other markers of intrathecal immune response in patients with herpes simplex encephalitis. (8077727)	Aurelius E.... StrannegAYrd O.	1994	IL2RB
50	Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. (8036512)	Rogers S.W.... McNamara J.O.	1994	GRIA3

Genes related to encephalitis according to GeneCards:

(show top 50)    (show all 297)

id	Symbol	Description	Score	GeneCards Section Context
1	TREX1	three prime repair exonuclease 1	11.0	Publications, Summaries
2	ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	11.0	Aliases & Descriptions
3	FER	fer (fps/fes related) tyrosine kinase	11.0	Aliases & Descriptions
4	PRNT	prion protein (testis specific)	11.0
5	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
6	MYH16	myosin, heavy chain 16 pseudogene	11.0	Summaries
7	TLR3	toll-like receptor 3	11.0	Publications
8	IVNS1ABP	influenza virus NS1A binding protein	11.0	Publications
9	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
10	STAB2	stabilin 2	11.0
11	CD40LG	CD40 ligand	11.0	Publications
12	GSR	glutathione reductase	11.0	Publications
13	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	11.0
14	IFNA1	interferon, alpha 1	11.0	Publications
15	UNC93B1	unc-93 homolog B1 (C. elegans)	11.0	Publications
16	SH2D3C	SH2 domain containing 3C	11.0
17	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
18	TAT	tyrosine aminotransferase	11.0	Publications
19	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
20	GFAP	glial fibrillary acidic protein	11.0	Publications
21	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
22	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
23	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0	Publications
24	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0
25	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
26	IFNG	interferon, gamma	11.0	Publications
27	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
28	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B	11.0
29	IFIT2	interferon-induced protein with tetratricopeptide repeats 2	11.0	Publications
30	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
31	ERF	Ets2 repressor factor	11.0
32	HRSP12	heat-responsive protein 12	11.0
33	SH2D3A	SH2 domain containing 3A	11.0
34	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa	11.0	Publications
35	OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	11.0	Publications
36	OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	11.0	Publications
37	MOG	myelin oligodendrocyte glycoprotein	11.0	Publications
38	SAT1	spermidine/spermine N1-acetyltransferase 1	11.0	Publications
39	ICAM2	intercellular adhesion molecule 2	11.0	Publications
40	ICAM3	intercellular adhesion molecule 3	11.0	Publications
41	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	11.0	Functions, Publications
42	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
43	TYK2	tyrosine kinase 2	11.0	Publications
44	CALB1	calbindin 1, 28kDa	11.0	Publications
45	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
46	GRIA3	glutamate receptor, ionotropic, AMPA 3	11.0	Publications
47	CLNK	cytokine-dependent hematopoietic cell linker	11.0
48	HELLS	helicase, lymphoid-specific	11.0	Publications
49	AMPH	amphiphysin	11.0	Publications
50	IFNB1	interferon, beta 1, fibroblast	11.0	Publications

Pathways related to encephalitis according to GeneDecks:

(show top 50)    (show all 173)

id	Pathway	Score	Top Affiliating Genes
1	Measles20	11.8	PIK3CG, SH2D1A, MYD88, MX1, CD46, IL12A
2	Immune System38	11.6	VCAM1, RAB7A, CLEC5A, UNC93B1, LGALS3, CIITA
3	IL-6 Pathway36	11.2	BMP6, RAF1, IL10, IL12A, IL12B, IL16
4	Hepatitis C20	11.2	PIK3CG, RAF1, CLDN5, MAPK8, MAPK14, IFIT1
5	Influenza A20	11.2	PIK3CG, MYD88, RAF1, CIITA, MX1, FURIN
6	Toll-like receptor signaling pathway20	10.9	PIK3CG, MYD88, JUN, FOS, IL12A, IL12B
7	ERK Signaling36	10.9	BMP6, RAF1, PAK6, ITGA4, IL10, IL12A
8	Chagas disease (American trypanosomiasis)20	10.8	PIK3CG, MYD88, JUN, FOS, IL10, IL12A
9	Endothelin-1 Signaling Pathway36	10.7	BMP6, RAF1, IL10, IL12A, IL12B, IL16
10	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.6	GZMB, IL12B, IL17A, IL1B, IL4, IL6
11	Jak-STAT signaling pathway20	10.6	PIK3CG, CNTF, BCL2L1, IL10, IL12A, IL12B
12	Cytokine-cytokine receptor interaction20	10.5	CNTF, VEGFA, CD40LG, IL10, IL12A, IL12B
13	RAR-Gamma-RXR-Alpha Degradation36	10.5	IL12A, IL15, IL16, MAPK14, CCL4, CCL7
14	Cytokine Network36	10.5	IL10, IL12A, IL12B, IL15, IL16, IL18
15	Neuroscience3	10.5	CNP, CNTNAP2, BRSK2, S100B, CDK5, GRIA1
16	Malaria20	10.5	SELE, VCAM1, MYD88, CD40LG, GYPC, IL10
17	African trypanosomiasis20	10.4	SELE, VCAM1, MYD88, IL10, IL12A, IL12B
18	Akt Signaling36	10.4	PIK3CG, RAF1, CD4, FGF1, IL10, IL12B
19	Regulation of eIF4 and p70S6K36	10.3	CD4, ITGA4, FGF1, IL12A, IL12B, IL15
20	TRAF Pathway36	10.3	MYD88, JUN, FOS, IL12A, IL12B, IL1B
21	Rheumatoid arthritis20	9.9	VEGFA, JUN, FOS, IL15, IL17A, IL18
22	Leishmaniasis20	9.9	MYD88, JUN, ITGA4, FOS, FCGR3A, IL10
23	SOCS Pathway36	9.8	BMP6, BCL2, CD4, FGF1, IL10, IL12A
24	MIF Mediated Glucocorticoid Regulation36	9.8	BMP6, BCL2, IL10, IL12A, IL12B, IL15
25	Th1 Differentiation37	9.7	JUN, CD4, FOS, IL10, IL12A, IL12B
26	Rho Family GTPases36	9.7	BMP6, RAF1, PAK6, BDNF, BCL2, JUN
27	all-trans-Retinoic Acid Signaling in Brain36	9.7	BMP6, BCL2, IL10, IL12A, IL12B, IL15
28	Cell adhesion molecules (CAMs)20	9.6	CNTN1, CNTNAP2, CLDN5, CD8A, CD4, ITGA4
29	T cell receptor signaling pathway20	9.6	PIK3CG, RAF1, PAK6, JUN, CD8A, CD4
30	PGC1Alpha Pathway36	9.6	BMP6, BCL2, CD4, IL12A, IL12B, IL15
31	Tuberculosis20	9.6	MYD88, RAF1, RAB5A, RAB7A, BCL2, CIITA
32	Pertussis20	9.5	MYD88, JUN, FOS, IL10, IL12A, IL12B
33	Amyotrophic lateral sclerosis (ALS)20	9.5	RAB5A, BCL2, BCL2L1, GRIA1, GRIN2B, MAPK14
34	PEDF Induced Signaling36	9.4	BMP6, RAF1, BDNF, BCL2, BCL2L1, FOS
35	MIF Regulation of Innate Immune Cells36	9.4	BMP6, BCL2, JUN, FOS, IL10, IL12A
36	STAT3 Pathway36	9.4	BMP6, RAF1, BCL2, CD4, IL10, IL12A
37	PAK Pathway36	9.3	BMP6, PAK6, BDNF, BCL2, FGF1, IL10
38	NFAT Signaling and Lymphocyte Interactions36	9.2	BMP6, BCL2, CD4, FCER2, IL12A, IL12B
39	p38 Signaling36	9.2	BMP6, BDNF, BCL2, CD4, FGF1, IL10
40	Glucocorticoid Receptor Signaling36	9.1	BMP6, BCL2, JUN, CD4, FOS, IL10
41	14-3-3 Induced Apoptosis36	9.1	MYD88, BCL2, JUN, FOS, IL1B, FADD
42	Toxoplasmosis20	9.1	PIK3CG, MYD88, BCL2, BCL2L1, CIITA, CD40LG
43	Tec Kinases Signaling36	9.1	MYD88, BMP6, PAK6, BDNF, BCL2, CD4
44	JAK-STAT Pathway36	9.0	BMP6, RAF1, BDNF, BCL2, JUN, CD4
45	Apoptotic Pathways Triggered By HIV136	9.0	BCL2, BCL2L1, CD4, FADD, MAPK8, MAP3K5
46	JNK Pathway36	8.9	BMP6, RAF1, PAK6, BCL2, JUN, CD4
47	TGF-Beta Pathway36	8.9	BMP6, BDNF, BCL2, JUN, CD4, FOS
48	MAPK Family Pathway36	8.9	BMP6, RAF1, BDNF, BCL2, JUN, CD4
49	Antioxidant Action of Vitamin-C36	8.9	BMP6, BDNF, BCL2, JUN, CD4, FOS
50	Molecular Mechanisms of Cancer36	8.8	PIK3CG, BMP6, RAF1, BDNF, BCL2, BCL2L1

Compounds related to encephalitis according to GeneDecks:

(show top 50)    (show all 486)

id	Compound	Score	Top Affiliating Genes
1	nitric oxide32 9 18 9	15.1	CNTF, SELE, VCAM1, MYD88, BMP6, LGALS3
2	cysteine32	11.4	RAF1, RAB5A, BCL2L1, LGALS3, CHRNA7, S100B
3	rantes32	11.3	SELE, VCAM1, MYD88, BMP6, CIITA, MX1
4	cyclosporin a32 42	12.1	PIK3CG, RAF1, CIITA, S100B, B2M, JUN
5	ivig32	11.1	FCGR3A, IL18R1, MBP, CCL4, CCR5, IFNB1
6	fibrinogen32	11.1	SELE, VCAM1, LGALS3, FURIN, CD79A, CD40LG
7	egcg32	11.1	PIK3CG, RAF1, BCL2L1, ITIH4, APP, MAPK8
8	glutamate32	11.1	CNP, CNR1, CNR2, BMP6, LGALS3, CD79A
9	poly(i-c)32	11.1	VCAM1, MX1, IL12B, IL15, IL18, IL1B
10	morphine32 9 9	13.0	CNR1, CDK5, ITIH4, GRIA1, IL5, CCL4
11	il 1032	10.9	BMP6, CD8A, IL10, IL12B, IL15, IL18
12	parthenolide32	10.9	PIK3CG, BCL2L1, IL6, MAPK8, MAPK14, CCL2
13	atp32	10.8	MYD88, MYBPC1, BDNF, BCL2L1, LGALS3, MX1
14	ifn-alpha32	10.8	MX1, IL10, IL17A, IL18, IL2RB, IL6
15	ribonucleic acid32	10.8	BMP6, CIITA, CD9, FOS, GZMB, FGF1
16	hyaluronic acid32 18	11.8	BMP6, CHI3L1, B2M, GZMB, FGF1, GPT
17	calcium32 9 18 9	13.8	SH2D1A, CNR1, CNTF, MYBPC1, CLEC5A, CLNK
18	neopterin32	10.7	MX1, B2M, CD79A, CD4, CD40LG, CD9
19	aspirin32 34 18	12.7	CNR1, SELE, BMP6, RAF1, LGALS3, CD79A
20	glutamine32	10.6	PIK3CG, BMP6, RAF1, LGALS3, S100B, B2M
21	thalidomide32 42 9 9	13.6	VEGFA, BCL2L1, B2M, CD40LG, IL10, IL18
22	heparin32 9 18 9	13.6	PIK3CG, RAF1, LGALS3, FURIN, CD79A, CD4
23	arginine32	10.5	CNR1, CNR2, CNTF, KCNH2, SAT1, S100B
24	imiquimod32 42 9 9	13.5	BMP6, MX1, IL10, IL12B, IL18, IL5
25	4-hydroxynonenal32 18	11.5	JUN, FOS, GSR, IL10, APOE, APP
26	mdms32	10.5	CIITA, S100B, CD4, CD9, IL10, CCL4
27	forskolin32 42 9 9	13.3	CNP, CNR2, CNTF, BMP6, RAF1, BDNF
28	indomethacin32 9 9	12.3	CNR1, BMP6, RAF1, BDNF, B2M, CD79A
29	cholesterol32 9 18 9	13.3	CNR2, SELE, VCAM1, RAB7A, BECN1, BDNF
30	15-deoxy-delta-12,14-prostaglandin j232	10.3	PIK3CG, VEGFA, VCAM1, BMP6, BCL2L1, JUN
31	prostacyclin32	10.2	SELE, VEGFA, VCAM1, BMP6, FGF1, IL10
32	okt332	10.2	SELE, VCAM1, BMP6, CD79A, CD40LG, FCER2
33	cyclic amp32 18	11.1	CNR1, CNR2, CNTF, BDNF, KCNH2, CIITA
34	pge232	10.1	CNTF, SELE, VCAM1, RAF1, CIITA, CHRNA7
35	prednisolone32 9 9	12.0	VCAM1, BMP6, CD79A, GZMB, IL10, IL18
36	glatiramer acetate32 9 9	12.0	BDNF, CIITA, MOG, IL10, IL4, IL5
37	testosterone32 9 18 9	12.9	CNTF, SELE, VCAM1, RAF1, PAK6, BDNF
38	mptp32	9.6	BDNF, BCL2, BCL2L1, CHRNA7, MAPK8, CALB1
39	pdtc32	9.5	PIK3CG, SELE, VCAM1, RAF1, BCL2, BCL2L1
40	phosphatidylserine32 9 9	11.5	SELE, BCL2, CD79A, GZMB, MAPT, CASP1
41	imatinib32 34 9 9	12.2	PIK3CG, VEGFA, BMP6, RAF1, PAWR, BCL2
42	tacrolimus32 34 9 9	12.1	BMP6, RAF1, CD79A, ITGA4, GZMB, IL10
43	chloroquine32 34 9 9	12.0	BMP6, RAF1, KCNH2, CIITA, B2M, CD79A
44	sb 20358032 42	9.9	SELE, VEGFA, VCAM1, BMP6, BCL2, BCL2L1
45	curcumin32	8.9	PIK3CG, VEGFA, VCAM1, RAF1, BCL2, BCL2L1
46	dexamethasone32 42 34 9 9	12.9	VEGFA, VCAM1, BMP6, RAF1, BCL2, BCL2L1
47	doxorubicin32 34 9 9	INF	PIK3CG, SELE, VEGFA, BMP6, RAF1, PAWR
48	alanine32	INF	CNR1, CNTF, SELE, VCAM1, BMP6, RAF1
49	paclitaxel32 34 9 9	INF	PIK3CG, VEGFA, BMP6, RAF1, BDNF, BCL2
50	cisplatin32 34 9 9	INF	REV3L, CNR2, VEGFA, BMP6, RAF1, BDNF

Cellular components related to encephalitis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	12.5	PTS, PTGS1, PTPN11, DDX42, DDX58, DDX60
2	neuronal cell body	GO:043025	10.2	CALB1, SST, NTRK2, TGFB2, TGFB3, DPYSL5
3	external side of plasma membrane	GO:009897	9.9	ADA, CXCR4, CXCR3, CXCL9, CXCL12, CXCL10
4	cell surface	GO:009986	9.6	ADA, GRIN2B, GRIA1, ITGA4, CD46, FURIN
5	axon	GO:030424	9.6	EPHB1, ADRB2, STAT1, TGFB2, TNFRSF1A, CALB1
6	dendrite	GO:030425	9.2	CCK, ALOX5, CALB1, DPYSL5, STAT1, EPHB1
7	membrane raft	GO:045121	9.1	TNF, TNFRSF1A, PTPRC, KRAS, EPHB1, CASP8
8	integral to plasma membrane	GO:005887	INF	NTRK2, PTPRC, TNFRSF1A, TNF, TPO, HLA-DRB1
9	extracellular region	GO:005576	INF	PRL, PRNT, TF, TGFB3, TGFB2, TG
10	plasma membrane	GO:005886	INF	PTPRC, ICAM2, ICAM1, IFNAR2, GPR162, CCR5
11	extracellular space	GO:005615	INF	TNFRSF1A, IL6ST, IL6, IL5, IL4, IL32
12	cytosol	GO:005829	INF	PTPN11, DDX58, OAS1, OAS2, OAS3, OASL

Biological processes related to encephalitis according to GeneDecks:

(show top 50)    (show all 80)

id	Name	GO ID	Score	Top Affiliating Genes
1	type I interferon-mediated signaling pathway	GO:060337	11.6	ISG15, MX1, IFIT1, IFIT2, IFNA8, IFNAR2
2	cytokine-mediated signaling pathway	GO:019221	11.6	CX3CL1, STAT1, STAT2, TYK2, KRAS, RPS27A
3	cell-cell signaling	GO:007267	11.4	CXCL9, CCR5, CCL3, TXN, SST, NTF3
4	response to virus	GO:009615	11.4	IFIT2, ZNF175, BST2, MYD88, BECN1, UNC93B1
5	cellular response to interferon-gamma	GO:071346	11.4	CCL2, CCL5, NOS2, CCL3, AQP4, IL18
6	virus-host interaction	GO:019048	11.4	IL2RB, IL16, ISG15, POLA1, CD46, SCRIB
7	chemotaxis	GO:006935	11.3	CCR5, IL4, CXCR3, C3AR1, CCL2, CXCL9
8	positive regulation of tumor necrosis factor production	GO:032760	11.3	TLR3, TICAM1, IL18, TLR2, TNFRSF1A, IFNG
9	positive regulation of T cell proliferation	GO:042102	11.2	VCAM1, IL12A, IFNG, CCL5, IL6ST, IL6
10	aging	GO:007568	11.2	CCL5, TGFB2, TSPO, PTGS1, F3, CCL2
11	interferon-gamma-mediated signaling pathway	GO:060333	11.1	VCAM1, CIITA, B2M, IFNG, ICAM1, HLA-B
12	negative regulation of viral genome replication	GO:045071	11.1	TNF, OAS1, OAS3, OASL, RSAD2, CCL5
13	positive regulation of inflammatory response	GO:050729	11.1	IL12B, IL15, IL18, CCL3, TLR2, TGM2
14	defense response to virus	GO:051607	11.0	RSAD2, TLR3, TICAM1, CXCL10, CXCL9, IL12B
15	neutrophil chemotaxis	GO:030593	11.0	CCL2, IFNG, TGFB2, CX3CL1, IL1B, C5AR1
16	lipopolysaccharide-mediated signaling pathway	GO:031663	10.9	IL18, CCL3, CCL5, TNF, NFKBIA, TLR2
17	positive regulation of apoptotic process	GO:043065	10.9	CCK, PTPRC, TSPO, TLR3, TGFB2, SOD1
18	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.9	CAT, IL6, IL1B, FER, MYD88, ICAM1
19	platelet activation	GO:030168	10.8	TGFB3, TF, CX3CL1, SOD1, PECAM1, PIK3CG
20	MAPK cascade	GO:000165	10.8	CCL5, CCL3, CCR5, CCL2, MAP3K5, IL1B
21	inflammatory response	GO:006954	10.8	CCL4, CNR2, PIK3CG, SELE, MYD88, BMP6
22	blood coagulation	GO:007596	10.8	PTPN11, PIK3CG, NOS2, MAPK14, RAF1, PECAM1
23	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.7	NFKBIA, MAPK14, TNF, GDNF, E2F1, ADRB2
24	positive regulation of chemokine biosynthetic process	GO:045080	10.7	TICAM1, TLR3, TNF, IFNG, IL4, MYD88
25	response to lipopolysaccharide	GO:032496	10.7	SELE, FER, IL12A, JUN, IDO1, CXCL10
26	leukocyte cell-cell adhesion	GO:007159	10.6	PTPRC, ICAM1, CD40LG, ITGA4, SELE, VCAM1
27	angiogenesis	GO:001525	10.6	STAB2, JUN, PIK3CG, FGF1, EPHB1, CXCR3
28	positive regulation of smooth muscle cell proliferation	GO:048661	10.6	TGM2, ELANE, CCL5, IL6, JUN, CX3CL1
29	positive regulation of gene expression	GO:010628	10.5	VEGFA, TGFB2, KRAS, PLP1, NTRK2, CCL5
30	negative regulation of growth of symbiont in host	GO:044130	10.5	IFNG, TNF, ELANE, IL10, MYD88, IL12B
31	platelet degranulation	GO:002576	10.5	SOD1, ALB, PECAM1, TGFB3, TF, APP
32	positive regulation of neuron apoptotic process	GO:043525	10.4	JUN, CCL3, IL18, TGFB2, TNF, HRK
33	cellular response to mechanical stimulus	GO:071260	10.3	FADD, TLR3, IL18, IL1B, MAPK8, CASP1
34	cellular response to organic cyclic compound	GO:071407	10.3	CCL2, IL18, GRIN2B, IL1B, CCL3, CCL5
35	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.2	F2R, BST2, MYD88, S100B, FLNA, IL1B
36	activation of MAPK activity	GO:000187	10.2	PTPN11, RPS27A, MAPK14, IL1B, CHRNA7, TGFB3
37	cell surface receptor signaling pathway	GO:007166	10.2	MYD88, CD274, MAPK14, CCL2, CD4, CCR5
38	response to hypoxia	GO:001666	10.1	CHRNA7, IL18, IL1B, CCL2, CAT, CASP1
39	humoral immune response	GO:006959	9.9	NOTCH2, TNF, IFNB1, CCL2, IL6, BCL2
40	negative regulation of smooth muscle cell proliferation	GO:048662	9.9	PPARG, APOD, IL15, IL12B, IFNG, COMT
41	cellular response to organic substance	GO:071310	9.9	CASP1, CALB1, MAP2, IL1B, CD68, BCL2
42	B cell proliferation	GO:042100	9.9	IFNB1, BCL2, CD79A, CD40LG, IL10, PTPRC
43	immune response	GO:006955	9.9	GEM, IL5, IL4, IL32, IL18R1, IL18
44	induction of apoptosis	GO:006917	9.9	STAT1, HRK, TNF, PPARG, NOTCH2, TLR2
45	signal transduction	GO:007165	9.8	DPYSL5, TG, TLR3, TLR2, PPARG, NTF3
46	negative regulation of neuron apoptotic process	GO:043524	9.8	JUN, NTF3, F2R, BCL2L1, NTRK2, KRAS
47	apoptotic process	GO:006915	9.7	BCL2, GRK1, BCL2L1, GZMB, E2F1, CXCR4
48	anti-apoptosis	GO:006916	9.5	CCL2, APOE, IL1B, IL10, CD40LG, BCL2L1
49	innate immune response	GO:045087	9.4	PIK3CG, BST2, MYD88, TICAM1, CLEC5A, MAPK14
50	response to drug	GO:042493	9.0	GAL, TNF, ABCB1, CCL2, CASP1, ICAM1

Molecular functions related to encephalitis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	double-stranded RNA binding	GO:003725	11.1	STRBP, TLR3, EIF2AK2, OASL, OAS3, OAS2
2	chemokine activity	GO:008009	10.7	CXCL10, CXCL11, CXCL12, CXCL9, CX3CL1, CCL5
3	cytokine activity	GO:005125	10.6	CXCL9, IL32, IL1B, IL18, IL17A, IL16
4	2-5-oligoadenylate synthetase activity	GO:001730	10.5	OASL, OAS3, OAS2, OAS1
5	growth factor activity	GO:008083	10.3	IL5, IL6, NTF3, NTF4, TGFB2, TGFB3
6	receptor binding	GO:005102	10.0	CRAT, NOS2, TGFB2, CX3CL1, CXCL10, CXCL12
7	protein homodimerization activity	GO:042803	9.8	CRP, NTRK2, SUPV3L1, PTS, TREX1, HM13
8	protein heterodimerization activity	GO:046982	9.3	NPM1, POLA1, TGFB3, TGFB2, TLR2, ENO2
9	protein binding	GO:005515	7.9	CX3CL1, ELANE, ACP1, EIF2AK2, ABCB1, LTF