MCID: ENC004
MIFTS: 66

Encephalitis

Categories: Neuronal diseases, Rare diseases, Infectious diseases

Aliases & Classifications for Encephalitis

Summaries for Encephalitis

NINDS : 50 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone can get encephalitis or meningitis.Inflammation from encephalitis and meningitis produce a wide range of symptoms.  Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Symptoms of meningitis, which may appear suddenly, often include high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, and vomiting. Changes in behavior such as confusion, sleepiness, and difficulty waking up may also occur. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head). Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately.

MalaCards based summary : Encephalitis is related to tick-borne encephalitis and herpes simplex encephalitis, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Encephalitis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Azithromycin and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms.

MedlinePlus : 40 Encephalitis is an inflammation of the brain. Usually the cause is a viral infection, but bacteria can also cause it. It can be mild or severe. Most cases are mild. You may have flu-like symptoms. With a mild case, you may just need rest, plenty of fluids, and a pain reliever. Severe cases need immediate treatment. Symptoms of severe cases include Severe headache Sudden fever Drowsiness Vomiting Confusion Seizures In babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. Severe cases may require a stay in the hospital. Treatments include oral and intravenous (IV) medicines to reduce inflammation and treat infection. Patients with breathing difficulties may need artificial respiration. Some people may need physical, speech, and occupational therapy once the illness is under control. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 Encephalitis is inflammation of the brain. Severity is variable. Symptoms may include headache, fever,... more...

Related Diseases for Encephalitis

Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 628)
# Related Disease Score Top Affiliating Genes
1 tick-borne encephalitis 34.1 CCR5 CD209 CXCL10 TLR3
2 herpes simplex encephalitis 34.0 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
3 viral encephalitis 33.5 CCL2 CCL5 CXCL10 IL1B
4 japanese encephalitis 33.3 CCL5 CD209 CLEC4G CLEC4M CXCL10 DDX58
5 west nile virus 32.2 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2
6 herpes simplex 31.1 CD209 DDX58 IRF3 TICAM1 TLR3 TRAF3
7 malaria 30.9 CCL2 CCL5 CXCL10 CXCL9 IL1B
8 dengue virus 30.5 CD209 DDX58 RPSA RSAD2
9 measles 30.4 CD209 DDX58 TLR3
10 rabies 30.3 CCL5 CXCL10 IRF3 TLR3
11 yellow fever 30.3 CCL5 CCR5 RSAD2
12 endotheliitis 30.2 CXCL10 CXCL9
13 viral meningitis 30.2 CCL2 CCL5 CXCL10
14 influenza 30.2 CCL5 DDX58 RSAD2 TLR3
15 stomatitis 30.1 DDX58 IL1B RSAD2
16 chikungunya 29.9 CCL5 DDX58 IL1B RSAD2
17 opsoclonus-myoclonus syndrome 29.8 CXCL10 CXCL9
18 trypanosomiasis 29.8 CCL2 CCL5 IL1B
19 cerebral hemorrhage 29.6 GFAP IL1B
20 mycobacterium tuberculosis 1 29.6 CD209 CXCL10 CXCL9
21 neuritis 29.2 AQP4 CCL2 CCL5 CXCL10 IL1B
22 hepatitis c 29.2 CLEC4M CXCL10 DDX58 IRF3 TLR3
23 hepatitis c virus 29.1 CCR5 CLEC4M DDX58 IRF3 RSAD2
24 systemic lupus erythematosus 29.0 CCL2 CCL5 CCR5 CXCL10 IL1B TREX1
25 demyelinating disease 28.9 AQP4 CCL2 CCL5 CXCL10 IL1B
26 human immunodeficiency virus type 1 28.8 CCL2 CCL5 CCR5 CD209 CLEC4M CXCL10
27 severe acute respiratory syndrome 28.8 CCL2 CCL5 CD209 CLEC4M CXCL10 IRF3
28 multiple sclerosis 28.0 AQP4 CCL2 CCL5 CCR5 CXCL10 CXCL9
29 la crosse encephalitis 12.4
30 eastern equine encephalitis 12.4
31 st. louis encephalitis 12.4
32 limbic encephalitis 12.3
33 western equine encephalitis 12.3
34 rasmussen encephalitis 12.3
35 murray valley encephalitis 12.3
36 granulomatous amebic encephalitis 12.3
37 west nile encephalitis 12.2
38 autoimmune encephalitis 12.2
39 hashimoto's encephalitis 12.2
40 meningitis and encephalitis 12.2
41 venezuelan equine encephalitis 12.2
42 herpes simplex encephalitis 1 12.2
43 limbic encephalitis with lgi1 antibodies 12.2
44 hhv-6 encephalitis 12.2
45 powassan encephalitis 12.2
46 bickerstaff brainstem encephalitis 12.1
47 von economo's disease 12.1
48 herpes simplex encephalitis 2 12.1
49 herpes simplex encephalitis 3 12.1
50 herpes simplex encephalitis 4 12.0

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to Encephalitis

Symptoms & Phenotypes for Encephalitis

UMLS symptoms related to Encephalitis:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, headache, back pain

MGI Mouse Phenotypes related to Encephalitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 TREX1 UNC93B1 TRAF3 DDX58 AQP4 IL1B
2 homeostasis/metabolism MP:0005376 10.13 TREX1 UNC93B1 TLR3 CXCL10 TRAF3 DDX58
3 immune system MP:0005387 10.09 TREX1 UNC93B1 TRAF3 DDX58 AQP4 GFAP
4 liver/biliary system MP:0005370 9.5 TRAF3 TREX1 UNC93B1 DDX58 CCR5 CLEC4G
5 mortality/aging MP:0010768 9.44 TREX1 UNC93B1 TLR3 CXCL10 TRAF3 DDX58

Drugs & Therapeutics for Encephalitis

Drugs for Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 1 83905-01-5 53477736 447043 55185
2
Dimenhydrinate Approved Phase 4 523-87-5 441281
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Ethanol Approved Phase 4 64-17-5 702
5
Formaldehyde Approved, Vet_approved Phase 4,Phase 3 50-00-0 712
6
Minocycline Approved, Investigational Phase 4,Phase 1 10118-90-8 5281021
7
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Phase 2 68-35-9 5215
8
Sulfamethoxazole Approved Phase 4 723-46-6 5329
9
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 58-14-0 4993
10
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
11
Natalizumab Approved, Investigational Phase 4 189261-10-7
12
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
13
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
15 Racepinephrine Approved Phase 4 329-65-7
16
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 1 58-05-9 143 6006
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-30-3 6037
18
Lactitol Investigational Phase 4,Phase 3,Phase 2 585-86-4 3871
19 glucocorticoids Phase 4,Phase 3,Phase 2
20 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
21 Hormone Antagonists Phase 4,Phase 3,Phase 2
22 Hormones Phase 4,Phase 3,Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
24 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
25 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
27 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
29 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
30 Folic Acid Antagonists Phase 4,Phase 2,Phase 1
31 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
33 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3
34 Vitamin B Complex Phase 4,Phase 2,Phase 1
35 Disinfectants Phase 4,Phase 3
36 Antibodies, Blocking Phase 4,Phase 3,Phase 2
37 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
39 Antimalarials Phase 4,Phase 3,Phase 2,Phase 1
40 Antibiotics, Antitubercular Phase 4,Phase 3
41 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Prednisolone acetate Phase 4,Phase 2
44 Methylprednisolone acetate Phase 4,Phase 2
45 Methylprednisolone Hemisuccinate Phase 4,Phase 2
46 Hematinics Phase 4
47 Vasoconstrictor Agents Phase 4
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
49 Epinephryl borate Phase 4
50 Epoetin alfa Phase 4 113427-24-0

Interventional clinical trials:

(show top 50) (show all 286)

# Name Status NCT ID Phase Drugs
1 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
2 Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine Unknown status NCT01398540 Phase 4
3 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
4 TBE Vaccination in Allergic Patients Unknown status NCT02511535 Phase 4
5 A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2 Completed NCT01656200 Phase 4
6 Long-term Immunogenicity and Safety of Fourth Administration of Boryung Cell-Culture Japanese Encephalitis Vaccineinj Completed NCT02532569 Phase 4
7 Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX Completed NCT02526550 Phase 4
8 Immunogenicity of Co-administration of Measles and Japanese Encephalitis Vaccines Completed NCT02643433 Phase 4
9 6-year Antibody Check After Third Vaccination Against Japanese Encephalitis Completed NCT02039440 Phase 4
10 Study to Evaluate Long Term Immunogenicity up to 10 Years After the First Booster Immunization With Tick Borne Encephalitis Vaccine in Adults Who Received 1 of 3 Different Primary Vaccination Schedules Completed NCT01562444 Phase 4
11 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
12 An Extension Study to Determine the Persistence of Tick-borne Encephalitis (TBE)-Specific Antibody Responses Among Children and Adolescents Previously Immunized Against TBE Completed NCT01106482 Phase 4
13 TBE Antibody Persistence and Booster Vaccination Study in Children and Adolescents (Follow-up to Study 209) Completed NCT00161967 Phase 4
14 Long-term Immunogenicity After Receipt of JE Vaccine and Antibody Response and Safety to a Booster Dose Completed NCT02514746 Phase 4
15 Tick-Borne Encephalitis (TBE) Seropersistence After First Booster in Children, Adolescents and Young Adults (Follow-Up to Study 700401) Completed NCT00894686 Phase 4
16 This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population Completed NCT01158599 Phase 4
17 TBE Antibody Persistence and Booster Vaccination Study in Adults (Follow-up to Study 223) Completed NCT00503529 Phase 4
18 Cervicovaginal Immune Responses to 3 Deltoid or Thigh Intramuscular (IM) TicoVac Completed NCT01710189 Phase 4 TicoVac
19 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
20 Immunogenicity and Safety Study of a Rapid Immunization Schedule With FSME-IMMUN 0.5 mL in Healthy Adults Aged 16 - 65 Years Completed NCT00161954 Phase 4
21 Post-licensure Safety Study of IMOJEV® in Thailand Completed NCT01981967 Phase 4
22 Humoral and Cellular Immunity of Low and High-responders After Tick-borne Encephalitis Vaccination Completed NCT00804219 Phase 4
23 Lot-to-lot Consistency Trial of JE Live Attenuated SA 14-14-2 Vaccine Completed NCT01567865 Phase 4
24 Evaluation of Long-Term Immunogenicity in Subjects Boosted With a TBE Vaccine for Adults Completed NCT00311493 Phase 4
25 Study of the Safety, Tolerability and Immune Response of TBE Vaccines Administered to Healthy Children Completed NCT00311441 Phase 4
26 TBE Seropersistence up to 10 Years After First Booster in Adults Completed NCT01582698 Phase 4
27 Study to Investigate the Seropersistence of TBE Virus Antibodies Approx. 3 Years After a Booster Vaccination With FSME-IMMUN 0.25 mL JUNIOR in Children Completed NCT00163618 Phase 4
28 Immunogenicity and Safety Study of a Third Vaccination With FSME-IMMUN 0.5 mL in Subjects Previously Vaccinated According to a Rapid Immunization Schedule (Follow-up to Study 225) Completed NCT00163540 Phase 4
29 Safety and Long-term Evaluation (up to 5 Years) of First Booster Immunization With Novartis' TBE Vaccine for Adults in Adolescents and Adults Completed NCT00387634 Phase 4
30 Influence of Persistent CMV-infection on Immune Senescence Completed NCT00461695 Phase 4
31 Immunogenicity of SA 14-14-2 JE Vaccine Completed NCT01635816 Phase 4
32 Evaluation of Long-Term Immunogenicity in Children and Adolescents Boosted With a New Pediatric TBE Vaccine After Five Years Completed NCT00452621 Phase 4
33 Investigation of the Seropersistence of TBE Antibodies and the Booster Response to FSME-IMMUN 0.5 ml in Adults Aged 18 - 67 Years Completed NCT00161785 Phase 4
34 Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
35 Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events Completed NCT01417949 Phase 4
36 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
37 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
38 Minocycline to Treat Childhood Regressive Autism Completed NCT00409747 Phase 4 Minocycline
39 Kaiser Permanente HIV Cohort Study Completed NCT01339403 Phase 4
40 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03004209 Phase 4 Erythropoietin
41 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
42 The Aim of This Study is to Investigate the Persistence of Antibody Response in Adults up to 15 Years After One Booster Dose of GlaxoSmithKline (GSK) Biologicals' Encepur Adults Vaccine Active, not recruiting NCT03294135 Phase 4
43 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
44 Safety and Effectiveness of Switching Relapsing MS Patients Treated With Natalizumab at Risk for PML to Teriflunomide Active, not recruiting NCT01970410 Phase 4 teriflunomide
45 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
46 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
47 Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) Terminated NCT01211665 Phase 4 Methylprednisolone;Prednisolone
48 A Study to Evaluate the One Year Long-term Persistence of Immune Responses Following Two Different Rabies Vaccine Post-exposure Regimens in Chinese Children Withdrawn NCT03192371 Phase 4
49 Efficacy of Tacrolimus and I.V.-Immunoglobulins in Rasmussen Encephalitis Unknown status NCT00545493 Phase 2, Phase 3 Tacrolimus;i.v. immunoglobulins
50 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3 20% deet insect repellent;placebo control

Search NIH Clinical Center for Encephalitis

Cochrane evidence based reviews: encephalitis

Genetic Tests for Encephalitis

Genetic tests related to Encephalitis:

# Genetic test Affiliating Genes
1 Encephalitis 28

Anatomical Context for Encephalitis

MalaCards organs/tissues related to Encephalitis:

38
Brain, T Cells, Testes, Lung, Spinal Cord, Temporal Lobe, B Cells

Publications for Encephalitis

Articles related to Encephalitis:

(show top 50) (show all 5861)
# Title Authors Year
1
NMDA receptor autoimmunity in mania following HSV encephalitis. ( 29439749 )
2018
2
Semantic language deficit developing following herpes simplex encephalitis: reorganization "cannibalising" language centers? ( 29350572 )
2018
3
Diagnosing tick-borne encephalitis: a re-evaluation of notified cases. ( 29188467 )
2018
4
A case of primary central nervous system lymphoma arising at the site of remote herpes encephalitis. ( 29382621 )
2018
5
A Case of Bell's Palsy Complicated by Subsequent Herpes Simplex Virus Encephalitis. ( 29144221 )
2018
6
Meta-Analyses of Japanese Encephalitis Virus Infection, Dissemination, and Transmission Rates in Vectors. ( 29363456 )
2018
7
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection<i>In</i><i>Vitro</i>and in a Mouse Model. ( 29435494 )
2018
8
A Simple Mechanism Based on Amino Acid Substitutions is not a Critical Determinant of High Mortality of Japanese Encephalitis Virus Infection in Mice. ( 29401664 )
2018
9
Premature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis. ( 29174006 )
2018
10
Changes of Epidemiological Characteristics of Japanese Encephalitis Viral Infection and Birds as a Potential Viral Transmitter in Korea. ( 29441740 )
2018
11
Treatment strategies for autoimmune encephalitis. ( 29399043 )
2018
12
Febrile infection-related epilepsy syndrome (FIRES) with super-refractory status epilepticus revealing autoimmune encephalitis due to GABA<sub>A</sub>R antibodies. ( 29203057 )
2018
13
Severe dysautonomia as a main feature of anti-GAD encephalitis: Report of a paediatric case and literature review. ( 29370977 )
2018
14
Exposure to West Nile virus and tick-borne encephalitis virus in dogs in Spain. ( 29322674 )
2018
15
First detection of tick-borne encephalitis virus RNA in clinical specimens of acutely ill patients in Hungary. ( 29373305 )
2018
16
Possible autoantibody-negative limbic encephalitis after anterior temporal lobectomy for hippocampal sclerosis. ( 29053037 )
2018
17
Glioblastoma as differential diagnosis of autoimmune encephalitis. ( 29383516 )
2018
18
Effect of prior dengue infection on severity and outcome of Japanese encephalitis. ( 29411187 )
2018
19
Hemorrhagic encephalitis associated with H3N2 influenza A viral pneumonia. ( 29440541 )
2018
20
Risk assessment for Japanese encephalitis vaccination. ( 29244615 )
2018
21
Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series. ( 29349679 )
2018
22
Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017. ( 29386094 )
2018
23
Meningoencephaloradiculitis following infection with tick borne encephalitis virus: case report and review of the literature. ( 29313244 )
2018
24
Pediatric Bickerstaff brainstem encephalitis: a systematic review of literature and case series. ( 29177548 )
2018
25
Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children. ( 29227177 )
2018
26
Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus. ( 29343583 )
2018
27
Herpes simplex encephalitis relapse associated with positive N-methyl-D-aspartate receptor antibodies. ( 29450730 )
2018
28
Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies. ( 29379207 )
2018
29
Limbic Encephalitis Manifesting as Selective Amnesia and Seizure-like Activity: A Case Report. ( 29397673 )
2018
30
Autoimmune Encephalitis Epidemiology and a comparison to Infectious Encephalitis. ( 29293273 )
2018
31
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin I+/I^1 heterodimer through high-throughput screening. ( 29337164 )
2018
32
Autoimmune encephalitis with GABA<sub>A</sub>receptor antibodies in a 10-year-old girl. ( 29245105 )
2018
33
Evaluation of a Commercial Multiplex Molecular Panel For the Diagnosis of Infectious Meningitis and Encephalitis. ( 29436421 )
2018
34
Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report. ( 29403279 )
2018
35
The long-term outcome of tick-borne encephalitis in Central Europe. ( 29275872 )
2018
36
Evaluation and Management of Autoimmune Encephalitis: A Clinical Overview for the Practicing Child Psychiatrist. ( 29157501 )
2018
37
Trismus caused by paraneoplastic brainstem encephalitis. ( 29440480 )
2018
38
Severe Disseminated Necrotizing and Granulomatous Lymphadenitis and Encephalitis in a Dog Due to Sporotrichum pruinosum (Teleomorph: Phanerochaete chrysosporium). ( 29191132 )
2018
39
Functional failure of TLR3 and its signaling components contribute to herpes simplex encephalitis. ( 29305044 )
2018
40
Focal Encephalitis, Meningitis and Acute Respiratory Distress Syndrome Associated with Influenza A Infection. ( 29402867 )
2018
41
A protocol for investigating the association of vaccination and anti-NMDA receptor encephalitis. ( 28930529 )
2018
42
Long-term immunogenicity of an initial booster dose of an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC) and the safety and immunogenicity of a second JE-VC booster dose in children previously vaccinated with an inactivated, mouse brain-derived Japanese encephalitis vaccine. ( 29429815 )
2018
43
Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis. ( 29208406 )
2018
44
Comparison of myelin oligodendrocyte glycoprotein (MOG)-antibody disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD) when they co-exist with anti-NMDA (N-methyl-D-aspartate) receptor encephalitis. ( 29414288 )
2018
45
Influenza A(H5N1) Virus Infection in a Child With Encephalitis Complicated by Obstructive Hydrocephalus. ( 29020163 )
2018
46
IFNI^ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis. ( 29352287 )
2018
47
Human T-cell lymphotropic virus (HTLV)-associated encephalopathy: an under-recognised cause of acute encephalitis? Case series and literature review. ( 29423617 )
2018
48
Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. ( 29407211 )
2018
49
Anti-N-methyl-D-aspartate receptor encephalitis associated with acute Toxoplasma gondii infection: A case report. ( 29443773 )
2018
50
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. ( 29113740 )
2018

Variations for Encephalitis

Expression for Encephalitis

Search GEO for disease gene expression data for Encephalitis.

Pathways for Encephalitis

Pathways related to Encephalitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CCL2 CCL5 CCR5 CD209 CXCL10 DDX58
2
Show member pathways
13.32 CCL2 CCL5 CCR5 CXCL10 CXCL9 IL1B
3
Show member pathways
13.29 CCL2 CCL5 CCR5 CXCL10 DDX58 IL1B
4
Show member pathways
12.8 CCL2 CCL5 CD209 IL1B IRF3 TICAM1
5
Show member pathways
12.78 CCL2 CCL5 CCR5 CXCL10 CXCL9
6
Show member pathways
12.61 CCL5 CXCL10 DDX58 IL1B IRF3 TRAF3
7
Show member pathways
12.51 CCR5 DDX58 IRF3 TICAM1 TLR3 TRAF3
8
Show member pathways
12.37 DDX58 IRF3 TICAM1 TLR3 TREX1
9
Show member pathways
12.3 CCL2 CCL5 CXCL10 CXCL9 IL1B IRF3
10
Show member pathways
12.23 CCL2 CXCL10 IL1B TRAF3
11 12.17 CCL2 CCL5 CXCL10 DDX58 IL1B IRF3
12
Show member pathways
12.16 IRF3 TICAM1 TLR3 TRAF3
13
Show member pathways
12.11 CCL2 CCL5 CCR5 CXCL10 CXCL9
14
Show member pathways
12.09 CCL2 CCL5 CD209 CLEC4M CXCL10 DDX58
15 11.99 DDX58 IRF3 TICAM1 TLR3 TRAF3
16 11.93 AQP4 CCL2 CXCL10 GFAP IL1B
17
Show member pathways
11.87 CCL2 CCL5 CCR5 CXCL10 CXCL9
18 11.83 DDX58 IL1B TICAM1 TRAF3
19 11.75 CCL2 CCL5 IL1B
20 11.75 CCL2 CCL5 CXCL10 IL1B TRAF3
21 11.66 IL1B IRF3 TICAM1
22 11.57 CCL2 CCL5 IL1B
23 11.34 CCL2 CCL5 CCR5 CXCL10 IL1B
24 11.31 CXCL10 CXCL9 IL1B
25 11.16 CCL2 CCL5 CXCL10 CXCL9 IL1B
26 10.96 CCL2 CCL5 CXCL10 CXCL9 GFAP IL1B
27 10.83 CCL2 IL1B

GO Terms for Encephalitis

Cellular components related to Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 AQP4 CCR5 CD209 CXCL10 CXCL9

Biological processes related to Encephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 CXCL10 CXCL9 IL1B IRF3 TICAM1
2 viral process GO:0016032 9.97 CCR5 CD209 CLEC4G CLEC4M DDX58 IRF3
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B IRF3 TICAM1 TLR3
4 chemotaxis GO:0006935 9.95 CCL2 CCL5 CCR5 CXCL10 CXCL9
5 defense response GO:0006952 9.94 CCR5 CXCL10 CXCL9 TLR3
6 inflammatory response GO:0006954 9.92 CCL2 CCL5 CCR5 CXCL10 CXCL9 IL1B
7 cellular response to lipopolysaccharide GO:0071222 9.91 CCL2 CCR5 CXCL10 IRF3 TICAM1
8 innate immune response GO:0045087 9.91 CD209 CLEC4M DDX58 IRF3 RSAD2 TICAM1
9 cellular response to interferon-gamma GO:0071346 9.88 AQP4 CCL2 CCL5 TLR3
10 viral entry into host cell GO:0046718 9.88 CD209 CLEC4G CLEC4M RPSA
11 response to virus GO:0009615 9.88 CCL5 CXCL10 DDX58 RSAD2 TLR3
12 cellular response to organic cyclic compound GO:0071407 9.87 CCL2 CCL5 IL1B
13 cell chemotaxis GO:0060326 9.86 CCL2 CCL5 CXCL10
14 neutrophil chemotaxis GO:0030593 9.86 CCL2 CCL5 IL1B
15 positive regulation of T cell proliferation GO:0042102 9.86 CCL5 CD209 IL1B
16 positive regulation of type I interferon production GO:0032481 9.83 IRF3 TICAM1 TLR3
17 positive regulation of interleukin-6 production GO:0032755 9.83 DDX58 IL1B TICAM1 TLR3
18 protein kinase B signaling GO:0043491 9.82 CCL2 CCL5 IL1B
19 toll-like receptor signaling pathway GO:0002224 9.82 TLR3 TRAF3 UNC93B1
20 immune system process GO:0002376 9.81 CD209 CLEC4M DDX58 IRF3 RSAD2 TICAM1
21 negative regulation of type I interferon production GO:0032480 9.8 DDX58 IRF3 TRAF3
22 chemokine-mediated signaling pathway GO:0070098 9.8 CCL2 CCL5 CCR5 CXCL10 CXCL9
23 leukocyte cell-cell adhesion GO:0007159 9.78 CCL5 CD209 CLEC4M
24 positive regulation of interleukin-8 production GO:0032757 9.77 DDX58 IL1B TLR3
25 positive regulation of interferon-beta production GO:0032728 9.77 DDX58 IRF3 TLR3
26 response to exogenous dsRNA GO:0043330 9.76 DDX58 IRF3 TICAM1 TLR3
27 viral genome replication GO:0019079 9.73 CCL2 CD209 CLEC4M
28 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.73 IRF3 TICAM1 TLR3 TRAF3
29 regulation of type I interferon production GO:0032479 9.72 IRF3 TREX1
30 positive regulation of monocyte chemotaxis GO:0090026 9.72 CCL5 CXCL10
31 dendritic cell chemotaxis GO:0002407 9.72 CCL5 CCR5
32 necroptotic process GO:0070266 9.72 TICAM1 TLR3
33 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 TLR3
34 positive regulation of cAMP-mediated signaling GO:0043950 9.71 CXCL10 CXCL9
35 positive regulation of T cell migration GO:2000406 9.71 CCL5 CXCL10
36 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
37 toll-like receptor 3 signaling pathway GO:0034138 9.71 TICAM1 TLR3 UNC93B1
38 positive regulation of cAMP metabolic process GO:0030816 9.7 CXCL10 CXCL9
39 T cell chemotaxis GO:0010818 9.7 CXCL10 CXCL9
40 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 IRF3
41 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 DDX58 IL1B
42 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.68 TICAM1 TLR3
43 modulation by virus of host morphology or physiology GO:0019048 9.68 CD209 CLEC4M
44 positive regulation of interferon-beta biosynthetic process GO:0045359 9.67 TICAM1 TLR3
45 negative regulation of macrophage apoptotic process GO:2000110 9.67 CCL5 CCR5
46 cell-cell recognition GO:0009988 9.67 CD209 CLEC4M
47 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TICAM1 TLR3
48 cellular response to dsRNA GO:0071359 9.66 IRF3 TLR3
49 detection of virus GO:0009597 9.65 DDX58 TLR3
50 virion attachment to host cell GO:0019062 9.62 CD209 CLEC4M

Molecular functions related to Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 CCL2 CCL5 CXCL10 CXCL9 IL1B
2 mannose binding GO:0005537 9.4 CD209 CLEC4M
3 virion binding GO:0046790 9.37 CD209 CLEC4M
4 CXCR3 chemokine receptor binding GO:0048248 9.32 CXCL10 CXCL9
5 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL9
6 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4G CLEC4M RPSA
7 protein binding GO:0005515 10.21 AQP4 CCL2 CCL5 CCR5 CD209 CLEC4G

Sources for Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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