MCID: ENC004
MIFTS: 56

Encephalitis malady

Neuronal category

Summaries for Encephalitis

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Encephalitis is an inflammation of the brain. usually the cause is a viral infection, but bacteria can also cause it. it can be mild or severe. most cases are mild. you may have flu-like symptoms. with a mild case, you may just need rest, plenty of fluids, and a pain reliever. severe cases need immediate treatment. symptoms of severe cases include severe headache sudden fever drowsiness vomiting confusion seizures in babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. severe cases may require a stay in the hospital. treatments include oral and intravenous medicines to reduce inflammation and treat infection. patients with breathing difficulties may need artificial respiration. some people may need physical, speech, and occupational therapy once the illness is under control. nih: national institute of neurological disorders and stroke

MalaCards: Encephalitis is related to tick-borne encephalitis and venezuelan equine encephalitis. An important gene associated with Encephalitis is TREX1 (three prime repair exonuclease 1), and among its related pathways are Influenza A and Toll-like receptor signaling pathway. The compounds genistein and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Disease Ontology:8 Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures.

NINDS:44 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:64 Encephalitis (from Ancient Greek ἐγκέφαλος, egképhalos “brain”, composed of ἐν en,... more...

Aliases & Classifications for Encephalitis

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
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Related Diseases for Encephalitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the viral encephalitis family:

encephalitis autoimmune encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 485)
idRelated DiseaseScoreTop Affiliating Genes
1tick-borne encephalitis31.7RAF1
2venezuelan equine encephalitis31.6SH2D3C
3limbic encephalitis31.5GAD1
4eastern equine encephalitis31.4SH2D3C
5west nile encephalitis31.3RAF1, STAB2
6rasmussen encephalitis31.1GAD1, GSR
7st. louis encephalitis31.0RAF1
8arthritis30.5TAT, IFNG, TLR3, IVNS1ABP, CCL2, CXCL10
9la crosse encephalitis30.5STAB2
10yellow fever30.5RAF1, PRNT
11measles30.4CD40LG, TLR3
12rubella30.4CD40LG
13subacute sclerosing panencephalitis30.3IFNA1
14lyme disease30.2CD40LG, STAB2
15hepatitis e30.2CD40LG
16hemorrhagic fever30.1CD40LG
17acquired immunodeficiency syndrome30.0IFNA1, TAT
18hepatitis c30.0CXCL10, GSR, IFNA1, IFNG, TLR3, CD40LG
19systemic lupus erythematosus30.0CCL2, IFNG, IFNA1, CD40LG, CXCL10
20thrombocytopenia30.0IFNA1, RAF1, CD40LG
21newcastle disease30.0CXCL10, IVNS1ABP, IFNA1
22acute leukemia29.9GSR
23tetanus29.8TAT, CD40LG, IFNG, GAD1
24alzheimer's disease29.8TLR3, GAD1, RAF1, GSR
25hepatitis b29.8IFNA1, CXCL10, IFNG
26thyroiditis29.8IFNA1
27viral infectious disease29.6TAT, RAF1, CD40LG, IVNS1ABP, GAD1, IFNA1
28asthma29.6RAF1, CXCL10, IFNG, TLR3, CCL2, GSR
29tuberculosis29.6GSR, CXCL10, IFNG, TAT
30graves' disease29.6CXCL10, IFNG, GAD1
31dengue hemorrhagic fever29.6IVNS1ABP, CD40LG
32cryoglobulinemia29.6CD40LG, IFNA1
33severe acute respiratory syndrome29.6SH2D3C, CXCL10
34nephritis29.6CD40LG, CCL2
35vasculitis29.6CCL2, CD40LG, TAT
36kawasaki disease29.6CCL2
37viral hepatitis29.6IFNA1
38vitiligo29.6GSR
39arthropathy29.6CXCL10, IVNS1ABP
40japanese encephalitis11.1
41herpes simplex encephalitis11.1
42viral encephalitis11.0
43western equine encephalitis10.9
44murray valley encephalitis10.9
45west nile virus10.7
46autoimmune encephalitis10.7
47bickerstaff brainstem encephalitis10.6
48neonatal herpes10.5
49n syndrome10.5
50granulomatous amebic encephalitis10.5

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to encephalitis

Clinical Features for Encephalitis

Drugs & Therapeutics for Encephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Encephalitis

Drug clinical trials:

Search ClinicalTrials for Encephalitis

Search NIH Clinical Center for Encephalitis

Search CenterWatch for Encephalitis

Genetic Tests for Encephalitis

Anatomical Context for Encephalitis

Animal Models for Encephalitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Encephalitis

Sources:
51PubMed
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Articles related to Encephalitis:

(show top 50)    (show all 4596)
idTitleAuthorsYear
1
Detection and genetic characterization of tick-borne encephalitis virus (TBEV) derived from ticks removed from red foxes (Vulpes vulpes) and isolated from spleen samples of red deer (Cervus elaphus) in Croatia. (24035586)
2014
2
CD8 T lymphocytes encephalitis mimicking brain tumor in HIV-1 infection. (24277438)
2013
3
Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod. (24024233)
2013
4
A severe case of Angiostrongylus eosinophilic meningitis with encephalitis and neurologic sequelae in Hawa'i. (23901383)
2013
5
Fatal herpes encephalitis in a patient with small cell lung cancer following prophylactic cranial radiation--a case report with review of literature. (23898089)
2013
6
Data from the World Health Organization (WHO) National Network Laboratory for Japanese Encephalitis. (23853435)
2013
7
Provenance and geographic spread of St. Louis encephalitis virus. (23760463)
2013
8
Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis. (23031498)
2012
9
Antiviral Activity of Baicalein and Quercetin against the Japanese Encephalitis Virus. (23222683)
2012
10
A DNA vaccine for venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates. (21450977)
2011
11
Comparison of immune response generated against Japanese encephalitis virus envelope protein expressed by DNA vaccines under macrophage associated versus ubiquitous expression promoters. (21806845)
2011
12
Cross protection against lethal West Nile virus challenge in mice immunized with recombinant E protein domain III of Japanese encephalitis virus. (21515306)
2011
13
Limbic encephalitis presenting as a post-partum psychiatric condition. (21705029)
2011
14
Enzootic activity of pixuna and Rio Negro viruses (Venezuelan equine encephalitis complex) in a neotropical region of Argentina. (19402767)
2010
15
Unilateral Acute Retinal Necrosis 2 Months After Herpes Simplex Encephalitis. (20337321)
2010
16
Comparative analysis of immune responses to Russian spring-summer encephalitis and Omsk hemorrhagic fever viruses in mouse models. (20875909)
2010
17
MRI appearance of Rasmussen encephalitis. (19294372)
2009
18
Ocular motor and lid apraxia as initial symptom of anti-Ma1/Ma2-associated encephalitis. (19188579)
2009
19
Non-paraneoplastic limbic encephalitis associated with antibodies to potassium channels leading to bilateral hippocampal sclerosis in a pre-pubertal girl. (19251579)
2009
20
Potassium channel antibody-associated encephalitis with hypothalamic lesions and intestinal pseudo-obstruction. (18378260)
2008
21
Risk factors associated with St. Louis encephalitis seroprevalence in two populations from CA^rdoba, Argentina. (17915268)
2007
22
A chronic progressive case of enteroviral limbic encephalitis associated with autoantibody to glutamate receptor epsilon2. (17389802)
2007
23
Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. (17875912)
2007
24
Visualization of Central European tick-borne encephalitis infection in fatal human cases. (15977642)
2005
25
Venezuelan equine encephalitis virus-vectored vaccines protect mice against anthrax spore challenge. (12595467)
2003
26
Tick-borne encephalitis with hemorrhagic syndrome, Novosibirsk region, Russia, 1999. (12781020)
2003
27
Decreased antioxidant-defence mechanisms in cerebrospinal fluid (CSF) in patients with tick-borne encephalitis (TBE)]. (12418140)
2002
28
Limbic encephalitis and late-onset psychosis. (10910808)
2000
29
Rasmussen encephalitis in childhood. (10447611)
1999
30
Use of the polymerase chain reaction in the diagnosis of herpes simplex encephalitis: a decision analysis model. (9809689)
1998
31
HIV encephalitis and HIV leukoencephalopathy are associated with distinct clinical and radiological subtypes of the AIDS dementia complex. (9108957)
1997
32
Involvement of the white matter in the initial stage of herpes simplex encephalitis. (1501948)
1992
33
Venezuelan equine encephalitis-specific immunoglobulin responses: live attenuated TC-83 versus inactivated C-84 vaccine. (1474379)
1992
34
Specific activation of B-cell clones within the central nervous system in course of herpes simplex encephalitis. (1966066)
1990
35
Obstacle to early diagnosis of herpes simplex encephalitis via CSF. (1975373)
1990
36
Non-invasive diagnosis of herpes simplex encephalitis. (1967796)
1990
37
Powassan encephalitis in new brunswick. (21233909)
1990
38
Rasmussen encephalitis: epilepsia partialis continua secondary to chronic encephalitis. (2127355)
1990
39
Arbovirus isolations from mosquitoes collected during and after the 1982-1983 epizootic of western equine encephalitis in Argentina. (2880521)
1987
40
Biopsy histopathology in herpes simplex encephalitis and in encephalitis of undefined etiology. (6098083)
1984
41
Early detection in suspected herpes simplex encephalitis. (6494957)
1984
42
Clinical aspects of La Crosse encephalitis: preliminary report. (6867032)
1983
43
Teratological effects of western equine encephalitis virus on the fetal nervous system of Macaca mulatta. (7064113)
1982
44
Acute viral encephalitis. (6793180)
1981
45
St. Louis encephalitis: the Chicago experience. (434304)
1979
46
Effects of influenza, mumps, and western equine encephalitis viruses on fetal rhesus monkeys (Macaca mulatta). (117564)
1979
47
Mumps virus meningitis and encephalitis without parotitis. (750438)
1978
48
Studies of arthropod-borne virus infections in Chiroptera. 8. Evidence of natural St. Louis encephalitis virus infection in bats. (5453911)
1970
49
Overwintering of Western equine encephalitis virus. (13704125)
1960
50
Sequelae of western equine encephalitis. (14853039)
1951

Genetic Variations for Encephalitis

Expression for genes affiliated with Encephalitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Encephalitis

Search GEO for disease gene expression data for Encephalitis.

Pathways for genes affiliated with Encephalitis

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 53R&D Systems, 12EMD Millipore
See all sources

Pathways related to Encephalitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3IVNS1ABP, TICAM1, CCL2, TLR3, IFNG, IFNA1
2
Hide members
11.2RAF1, CXCL10, TICAM1, CCL2, IFNG, IFNA1
3
Hide members
11.2CD40LG, TREX1, IFNG, UNC93B1, IFNA1, TLR3
4
Hide members
10.9GAD1, IFNA1, CD40LG, IFNG
5
Hide members
10.9RAF1, TICAM1, TLR3, IFNA1
610.9TICAM1, IFNA1, RAF1, TLR3
7
Hide members
10.9RAF1, IFNG, IFNA1, FER
810.8IFNG, CCL2, GSR
9
Hide members
10.8CXCL10, TREX1, IFNA1
10
Hide members
10.8RAF1, CXCL10, IFNA1
11
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.8IFNA1, TLR3, TICAM1
1210.7UNC93B1, TLR3

Compounds for genes affiliated with Encephalitis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1genistein45 29 60 2 11 2416.6IFNG, CCL2, GSR, RAF1, TAT, CD40LG
2vegf4511.6TAT, CD40LG, CXCL10, CCL2, IFNG, IFNA1
3alanine4511.6RAF1, TAT, GSR, CD40LG, IFNA1, GAD1
4retinoic acid45 2412.5CXCL10, TAT, RAF1, IFNA1, TLR3, IFNG
5histamine45 29 2413.5CXCL10, RAF1, TAT, CD40LG, IFNG, CCL2
6pge24511.5RAF1, CXCL10, GSR, CD40LG, CCL2, IFNG
7cyclosporin a45 29 6013.5IFNG, IFNA1, GAD1, CD40LG, TAT, RAF1
82,5-oligoadenylate4511.4IFNG, TLR3, TAT, CXCL10, IFNA1
9poly(i-c)4511.4TICAM1, IFNG, IFNA1, CXCL10, TLR3
10ccl345 2912.4IFNG, IFNA1, CCL2, CXCL10, TAT
11chloroquine45 2 50 29 1115.4TAT, RAF1, GSR, IFNA1, CXCL10
12aspartate4511.4TAT, GAD1, CD40LG, CCL2, RAF1
13dexamethasone45 50 29 1114.4CD40LG, RAF1, TLR3, IFNA1, TAT
14arginine4511.4TAT, CCL2, GSR, GAD1, CD40LG, IFNG
15actinomycin d4511.3TAT, CD40LG, IFNA1, IFNG, CCL2
16il-124511.3CD40LG, CCL2, IFNG, IFNA1
17polyinosinic-polycytidylic acid4511.3CXCL10, IFNG, TLR3, IFNA1
18ifn-alpha4511.3CXCL10, IFNA1, TLR3, IFNG
19neopterin4511.3IFNG, IFNA1, CXCL10, CD40LG
20cisplatin45 50 60 1114.3GSR, RAF1, CD40LG, IFNA1, CCL2
21cycloheximide4511.2RAF1, TAT, IFNA1, CXCL10
22herbimycin a45 6012.2RAF1, CD40LG, IFNG, CCL2
23rantes4511.2CD40LG, IFNA1, IFNG
24creatinine4511.2CD40LG, GAD1, CCL2, GSR, CXCL10
25tacrolimus45 50 1113.2IFNG, RAF1, CXCL10, IFNA1
26imiquimod45 29 60 1114.2IFNA1, TLR3, IFNG
27prednisolone45 29 1113.1IFNA1, GAD1, TAT
28gsno4511.1GSR, CXCL10, IFNG
29mycophenolate mofetil45 50 1113.1CD40LG, IFNA1, IFNG
30valproate4511.1GSR, GAD1, CD40LG
31il 104511.1IFNG, CXCL10, CCL2
32ribavirin45 50 1113.1IFNG, CD40LG
33adenylate4511.1IVNS1ABP, CD40LG, GSR, TAT, CXCL10
34tarc4511.1CCL2, CXCL10, IFNG
35cycloferon4511.1IFNA1, IFNG
36gnrh4511.1GSR, GAD1, RAF1
37melphalan45 1112.0IFNA1, IFNG, GSR
38agar4511.0TAT, RAF1, CCL2
39endotoxin4511.0TLR3
40rituximab45 50 1113.0RAF1, CD40LG, IFNA1
41betaseron4511.0IFNG, IFNA1
42allergens4511.0CXCL10, IFNG, CD40LG
43indomethacin45 60 29 1114.0TAT
44resiquimod45 6011.8IFNA1, TLR3
453-hydroxyanthranilic acid45 2411.8IFNA1, IFNG
46n acetylcysteine4510.8CCL2, CD40LG, RAF1, GSR
47thalidomide45 50 60 1113.8CD40LG, IFNA1, IFNG
483-Sulfinoalanine11 2411.7GSR, GAD1
49pdtc4510.7RAF1, CCL2
50l-glutamic acid29 11 2412.5TAT, GSR, GAD1

GO Terms for genes affiliated with Encephalitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9CXCL10, CD40LG, STAB2, IFNG

Biological processes related to Encephalitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160711.2CXCL10, UNC93B1, IFNG, TLR3, TICAM1
2inflammatory responseGO:00695411.1TICAM1, CCL2, TLR3, CD40LG, CXCL10
3positive regulation of chemokine biosynthetic processGO:04508011.0IFNG, TLR3, TICAM1
4positive regulation of interleukin-12 productionGO:03273511.0TLR3, IFNG, CD40LG
5innate immune responseGO:04508711.0TICAM1, TLR3, UNC93B1, TREX1, RAF1
6positive regulation of tumor necrosis factor productionGO:03276010.9IFNG, TLR3, TICAM1
7toll-like receptor 3 signaling pathwayGO:03413810.8UNC93B1, TLR3, TICAM1
8positive regulation of interferon-beta biosynthetic processGO:04535910.8TICAM1, TLR3
9positive regulation of NF-kappaB transcription factor activityGO:05109210.8FER, TLR3, TICAM1
10defense response to bacteriumGO:04274210.7TLR3, IFNG, STAB2
11toll-like receptor signaling pathwayGO:00222410.5UNC93B1, TLR3, TICAM1

Products for genes affiliated with Encephalitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Encephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet