MCID: ENC004
MIFTS: 56

Encephalitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories

Summaries for Encephalitis

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MedlinePlus:32 Encephalitis is an inflammation of the brain. usually the cause is a viral infection, but bacteria can also cause it. it can be mild or severe. most cases are mild. you may have flu-like symptoms. with a mild case, you may just need rest, plenty of fluids, and a pain reliever. severe cases need immediate treatment. symptoms of severe cases include severe headache sudden fever drowsiness vomiting confusion seizures in babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. severe cases may require a stay in the hospital. treatments include oral and intravenous medicines to reduce inflammation and treat infection. patients with breathing difficulties may need artificial respiration. some people may need physical, speech, and occupational therapy once the illness is under control. nih: national institute of neurological disorders and stroke

MalaCards based summary: Encephalitis is related to limbic encephalitis and tick-borne encephalitis. An important gene associated with Encephalitis is UNC93B1 (unc-93 homolog B1 (C. elegans)), and among its related pathways are Trafficking and processing of endosomal TLR and OX40 Pathway. The compounds polyinosinic-polycytidylic acid and il-12 have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:9 Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures.

NINDS:42 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:63 Encephalitis (from Ancient Greek ?????????, enk more...

Aliases & Classifications for Encephalitis

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Related Diseases for Encephalitis

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Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 522)
idRelated DiseaseScoreTop Affiliating Genes
1limbic encephalitis32.4GAD1
2tick-borne encephalitis32.3RAF1
3st. louis encephalitis32.2RAF1
4herpes simplex31.6TLR3, UNC93B1, CXCL10, GAD1, TAT
5rasmussen encephalitis31.5GAD1, GSR
6yellow fever31.1RAF1
7pneumonia30.9TLR3, CXCL10, CCL2
8west nile fever30.8RAF1
9hemorrhagic fever30.8CD40LG
10newcastle disease30.5IVNS1ABP, CXCL10
11hepatitis30.4TAT, GSR, CXCL10
12demyelinating disease30.4IFNG, CCL2
13dementia30.4TAT, GSR, CXCL10
14malaria30.3TAT, GSR, IFNG
15arthritis30.3IVNS1ABP, TLR3, CXCL10, CCL2, IFNG, TAT
16hiv-130.2TAT, RAF1, GSR, CXCL10
17uveitis30.2CXCL10, CCL2, IFNG
18systemic lupus erythematosus30.2CXCL10, CCL2, IFNG, CD40LG
19influenza30.1IVNS1ABP, TLR3, CXCL10, IFNG, TAT, TRAF3
20dengue hemorrhagic fever30.1CD40LG, IVNS1ABP
21vasculitis30.0CD40LG, TAT, CCL2
22leukemia29.9FER, IFNG, RAF1, CD40LG, TRAF3
23tetanus29.8IFNG, GAD1, TAT, CD40LG
24ulcerative colitis29.8IFNG, CXCL10, TLR3
25graves' disease29.7CXCL10, LGALS3, IFNG, GAD1
26adenocarcinoma29.6CXCL10, LGALS3, RAF1, TAT, TRAF3
27tuberculosis29.5TAT, GSR, IFNG, CXCL10
28hepatitis c29.4TLR3, CXCL10, IFNG, GSR, CD40LG
29rheumatoid arthritis29.4CD40LG, IFNG, CCL2, CXCL10, TLR3, IVNS1ABP
30prostate cancer29.4FER, CXCL10, LGALS3, GSR, RAF1
31breast cancer29.3CXCL10, LGALS3, GSR, RAF1, GAD1, TRAF3
32hepatitis b29.2TLR3, CXCL10, IFNG, GSR, RAF1, TAT
33asthma29.1TLR3, CXCL10, CCL2, IFNG, GSR, RAF1
34ischemia29.0LGALS3, GSR, RAF1, GAD1, TAT
35malignant glioma28.8LGALS3, GSR, RAF1, TAT
36japanese encephalitis11.2
37herpes simplex encephalitis11.1
38venezuelan equine encephalitis11.1
39viral encephalitis11.0
40eastern equine encephalitis11.0
41western equine encephalitis10.9
42murray valley encephalitis10.9
43autoimmune encephalitis10.7
44west nile encephalitis10.7
45west nile virus10.7
46meningitis10.6
47neuronitis10.6
48la crosse encephalitis10.6
49neonatal herpes10.6
50granulomatous amebic encephalitis10.5

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to encephalitis

Symptoms for Encephalitis

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Drugs & Therapeutics for Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Encephalitis

Search NIH Clinical Center for Encephalitis

Genetic Tests for Encephalitis

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Anatomical Context for Encephalitis

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MalaCards organs/tissues related to Encephalitis:

31
Brain, T cells, Testes, Spinal cord, Lung, Temporal lobe, B cells, Monocytes, Kidney, Cortex, Myeloid, Bone, Liver, Eye, Breast, Skin, Endothelial, Pituitary, Bone marrow, Spleen, Cerebellum, Colon, Thyroid, Prostate, Neutrophil, Salivary gland, Occipital lobe, Lymph node, Heart, Pancreas, Ovary, Testis, Tonsil, Olfactory bulb, Thalamus, Amygdala, Trigeminal ganglion

Animal Models for Encephalitis or affiliated genes

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Publications for Encephalitis

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Articles related to Encephalitis:

(show top 50)    (show all 4933)
idTitleAuthorsYear
1
Acute hemorrhagic encephalitis: An unusual presentation of dengue viral infection. (25709166)
2015
2
C-65Neurocognitive Rehabilitation of a West Nile Encephalitis Survivor. (25176908)
2014
3
Encephalitis claims 13 more lives as Indian government launches vaccine against one cause of the outbreak. (24128978)
2013
4
Tick-borne encephalitis virus, Zealand, Denmark, 2011. (23764123)
2013
5
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
6
Magnetic resonance imaging findings in a case of congenital rubella encephalitis. (24489572)
2013
7
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
8
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
9
Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. (22787234)
2012
10
Low coverage and predictors of vaccination uptake against tick-borne encephalitis in Slovenia. (21398380)
2012
11
Pathogenic and vaccine strains of Japanese encephalitis virus elicit different levels of human macrophage effector functions. (22729616)
2012
12
Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011. (22958609)
2012
13
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
14
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
15
Serosurveillance for Japanese encephalitis and West Nile viruses in resident birds in Hawai'i. (20688669)
2010
16
ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV) (24479198)
2010
17
Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem. (20544248)
2010
18
Viral encephalitis associated with pandemic 2009 (H1N1) influenza A. (22767664)
2010
19
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
20
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
21
Tracking eastern equine encephalitis virus perpetuation in the northeastern United States by phylogenetic analysis. (18689638)
2008
22
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
23
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
24
Development of immunofiltration assay by light addressable potentiometric sensor with genetically biotinylated recombinant antibody for rapid identification of Venezuelan equine encephalitis virus. (15251409)
2004
25
Differential diagnosis of West Nile encephalitis. (15353960)
2004
26
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. (14687719)
2003
27
Viral encephalitis: familiar infections and emerging pathogens. (11853816)
2002
28
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
29
Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12. (12388728)
2002
30
First case of Nipah virus encephalitis in Singapore. (11480479)
2001
31
Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. (10841661)
2000
32
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
33
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
34
Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. (9434729)
1997
35
Two possible mechanisms for survival and initiation of Murray Valley encephalitis virus activity in the Kimberley region of Western Australia. (7625542)
1995
36
Experimental transmission of eastern equine encephalitis virus and Highlands J virus via semen of infected tom turkeys. (7677655)
1995
37
Induction of encephalitis in SJL mice by intranasal infection with herpes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. (1849158)
1991
38
Kluver Bucy syndrome with severe amnesia secondary to herpes encephalitis. (3203279)
1988
39
Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986. (2852209)
1988
40
Non-herpes simplex encephalitis is early exclusion of herpes simplex etiology possible? (2824204)
1987
41
Distribution of dopa-oxidase isozymes among mosquito vectors of viral encephalitis. (3917888)
1985
42
Powassan viral encephalitis: a review and experimental studies in the horse and rabbit. (2996203)
1985
43
Immunoglobulins in the cerebrospinal fluid: changes during acute viral encephalitis in mice. (7451970)
1981
44
Viral encephalitis in the OR. (227326)
1979
45
Quantitative studies of the vector competence of Aedes aegypti, Culex annulirostris and other mosquitoes (Diptera: Culicidae) with Murray Valley encephalitis and other Queensland arboviruses. (42801)
1979
46
Eastern equine encephalitis in Massachusetts, 1957-1976. A prospective study centered upon analyses of mosquitoes. (23676)
1978
47
Preparation of inactivated St. Louis encephalitis virus vaccine from hamster kidney cell culture. (5924439)
1966
48
ISOLATIONS OF ST. LOUIS ENCEPHALITIS VIRUS FROM DOMESTIC PIGEONS, COLUMBA LIVIA. (14159988)
1964
49
Development and persistence of western equine encephalitis virus antibodies in experimentally infected pigeons. (13437685)
1957
50
Polyradiculopathy in man produced by St. Louis encephalitis virus (SLE). (13076770)
1953

Variations for Encephalitis

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Expression for genes affiliated with Encephalitis

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Search GEO for disease gene expression data for Encephalitis.

Pathways for genes affiliated with Encephalitis

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Pathways related to Encephalitis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TLR3, UNC93B1
210.0TRAF3, IFNG
39.9TRAF3, CD40LG
49.7TRAF3, CCL2, CXCL10
59.6CD40LG, IFNG, CCL2
6
Show member pathways
thioredoxin pathway36
9.6GSR, IFNG, CCL2
7
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.6CCL2, RAF1, TRAF3
8
Show member pathways
9.6TRAF3, RAF1, IFNG
9
Show member pathways
9.5TRAF3, TICAM1, TLR3
109.5TLR3, TICAM1, TRAF3
11
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.5CD40LG, RAF1, IFNG
129.4TRAF3, CD40LG, TICAM1
139.4CXCL10, LGALS3, CCL2, IFNG
14
Show member pathways
9.3TREX1, CXCL10, TICAM1, TLR3
159.1TLR3, TICAM1, RAF1, TRAF3
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.1TLR3, TICAM1, RAF1, TRAF3
17
Show member pathways
8.9CXCL10, CCL2, IFNG, RAF1, CD40LG
18
Show member pathways
8.7FER, CXCL10, CCL2, RAF1
19
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.3TLR3, TICAM1, CXCL10, CCL2, IFNG, RAF1
20
Show member pathways
7.8TRAF3, IVNS1ABP, TLR3, TICAM1, CXCL10, CCL2

Compounds for genes affiliated with Encephalitis

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Compounds related to Encephalitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1polyinosinic-polycytidylic acid4310.0TLR3, CXCL10, IFNG
2il-124310.0CCL2, IFNG, CD40LG
3il 104310.0IFNG, CCL2, CXCL10
4gsno439.9GSR, IFNG, CXCL10
5tarc439.9CXCL10, CCL2, IFNG
6ifn-alpha439.9IFNG, CXCL10, TLR3
7ribavirin43 49 1211.8CD40LG, IFNG, CXCL10
8valproate439.7GSR, GAD1, CD40LG
9neopterin439.7CD40LG, IFNG, CXCL10
10poly(i-c)439.7TLR3, TICAM1, CXCL10, IFNG
11allergens439.7CD40LG, IFNG, LGALS3, CXCL10
122,5-oligoadenylate439.6TLR3, CXCL10, IFNG, TAT
13herbimycin a43 5910.6CD40LG, RAF1, IFNG, CCL2
14ccl343 2810.6CXCL10, CCL2, IFNG, TAT
15endotoxin439.5TLR3, CXCL10, CCL2, IFNG, CD40LG
16pdtc439.4CCL2, IFNG, RAF1
17gnrh439.4CCL2, GSR, RAF1, GAD1
18wortmannin439.4TLR3, CXCL10, LGALS3, CCL2, RAF1
19chloroquine43 2 49 28 1213.3TAT, RAF1, GSR, CXCL10
20l-glutamic acid28 24 1211.3TAT, GAD1, GSR
21n acetylcysteine439.2CCL2, GSR, RAF1, CD40LG
22creatinine439.2CXCL10, CCL2, GSR, GAD1, CD40LG
23nitric oxide43 24 1211.2TLR3, CXCL10, LGALS3, CCL2, IFNG, GAD1
24cisplatin43 49 59 1212.1CD40LG, RAF1, GSR, CCL2, LGALS3
25agar439.0LGALS3, CCL2, RAF1, TAT, CD40LG
26nmda43 2810.0TAT, GAD1, GSR, CCL2
27butyrate439.0LGALS3, IFNG, RAF1, TAT
28glutamine439.0LGALS3, CCL2, RAF1, GAD1, TAT
29cyclosporin a43 28 5911.0IFNG, RAF1, GAD1, TAT, CD40LG
30cycloheximide439.0TAT, RAF1, IFNG, CCL2, CXCL10
31pge2439.0CXCL10, CCL2, IFNG, GSR, RAF1, CD40LG
32indomethacin43 28 59 1212.0IFNG, GSR, RAF1, TAT, CD40LG
33histamine43 28 2410.8CXCL10, CCL2, IFNG, RAF1, TAT, CD40LG
34oxygen43 249.8LGALS3, CCL2, GSR, GAD1, TAT, TRAF3
35fibrinogen438.7CD40LG, TAT, CCL2, LGALS3
36adenylate438.7IVNS1ABP, CXCL10, GSR, TAT, CD40LG
37oligonucleotide438.7TLR3, LGALS3, RAF1, GAD1, TAT, TREX1
38dexamethasone43 49 28 1211.6TLR3, CXCL10, CCL2, IFNG, RAF1, TAT
39rantes438.6CD40LG, TLR3, TICAM1, CXCL10, CCL2, IFNG
40estrogen438.5CXCL10, LGALS3, GSR, RAF1, TAT, CD40LG
41arginine438.5LGALS3, CCL2, IFNG, GSR, GAD1, TAT
42vegf438.5CXCL10, LGALS3, CCL2, IFNG, RAF1, TAT
43retinoic acid43 249.5TLR3, CXCL10, LGALS3, IFNG, RAF1, TAT
44aspartate438.5CCL2, GSR, RAF1, GAD1, TAT, CD40LG
45genistein43 28 59 2 24 1213.5CXCL10, CCL2, IFNG, GSR, RAF1, TAT
46phosphatidylinositol438.3TLR3, FER, CXCL10, LGALS3, CCL2, RAF1
47cysteine438.3LGALS3, IFNG, GSR, RAF1, GAD1, TAT
48alanine438.1CXCL10, LGALS3, GSR, RAF1, GAD1, TAT
49serine438.1TLR3, TICAM1, LGALS3, CCL2, RAF1, TAT
50tyrosine437.7TLR3, FER, CXCL10, LGALS3, RAF1, GAD1

GO Terms for genes affiliated with Encephalitis

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Cellular components related to Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6CD40LG, IFNG, CXCL10
2extracellular spaceGO:00056158.7CD40LG, IFNG, CCL2, LGALS3, CXCL10

Biological processes related to Encephalitis according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-betaGO:003545810.3TLR3, TREX1
2macrophage chemotaxisGO:004824610.1CCL2, LGALS3
3positive regulation of interferon-beta biosynthetic processGO:004535910.1TICAM1, TLR3
4monocyte chemotaxisGO:000254810.1LGALS3, CCL2
5cellular response to interferon-gammaGO:007134610.1TLR3, CCL2
6positive regulation of interleukin-12 productionGO:003273510.0CD40LG, IFNG, TLR3
7neutrophil chemotaxisGO:00305939.9IFNG, CCL2, LGALS3
8positive regulation of chemokine biosynthetic processGO:00450809.9IFNG, TICAM1, TLR3
9positive regulation of tumor necrosis factor productionGO:00327609.8TLR3, TICAM1, IFNG
10TRIF-dependent toll-like receptor signaling pathwayGO:00356669.8TLR3, TICAM1, TRAF3
11response to gamma radiationGO:00103329.8CCL2, CXCL10
12MyD88-independent toll-like receptor signaling pathwayGO:00027569.8TRAF3, TICAM1, TLR3
13toll-like receptor 4 signaling pathwayGO:00341429.8TRAF3, TICAM1, TLR3
14cell surface receptor signaling pathwayGO:00071669.8IFNG, CCL2, CXCL10
15lipopolysaccharide-mediated signaling pathwayGO:00316639.8CCL2, TICAM1
16positive regulation of nitric oxide biosynthetic processGO:00454299.8IFNG, TICAM1
17toll-like receptor 3 signaling pathwayGO:00341389.7TLR3, UNC93B1, TICAM1, TRAF3
18toll-like receptor signaling pathwayGO:00022249.7TLR3, UNC93B1, TICAM1, TRAF3
19chemokine-mediated signaling pathwayGO:00700989.6CCL2, CXCL10
20defense response to virusGO:00516079.4IFNG, CXCL10, TICAM1, UNC93B1, TLR3
21chemotaxisGO:00069359.4FER, CXCL10, CCL2
22inflammatory responseGO:00069549.3TLR3, TICAM1, CXCL10, CCL2, CD40LG
23signal transductionGO:00071659.2TLR3, CXCL10, CCL2, RAF1, TRAF3
24positive regulation of NF-kappaB transcription factor activityGO:00510929.2FER, TICAM1, TLR3
25innate immune responseGO:00450878.7TLR3, UNC93B1, TICAM1, LGALS3, RAF1, TREX1

Products for genes affiliated with Encephalitis

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Sources for Encephalitis

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
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46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
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