MCID: ENC004
MIFTS: 56

Encephalitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories

Aliases & Classifications for Encephalitis

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Summaries for Encephalitis

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MedlinePlus:32 Encephalitis is an inflammation of the brain. usually the cause is a viral infection, but bacteria can also cause it. it can be mild or severe. most cases are mild. you may have flu-like symptoms. with a mild case, you may just need rest, plenty of fluids, and a pain reliever. severe cases need immediate treatment. symptoms of severe cases include severe headache sudden fever drowsiness vomiting confusion seizures in babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. severe cases may require a stay in the hospital. treatments include oral and intravenous medicines to reduce inflammation and treat infection. patients with breathing difficulties may need artificial respiration. some people may need physical, speech, and occupational therapy once the illness is under control. nih: national institute of neurological disorders and stroke

MalaCards based summary: Encephalitis is related to limbic encephalitis and tick-borne encephalitis. An important gene associated with Encephalitis is UNC93B1 (unc-93 homolog B1 (C. elegans)), and among its related pathways are Trafficking and processing of endosomal TLR and OX40 Pathway. The compounds polyinosinic-polycytidylic acid and il-12 have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:8 Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures.

NINDS:43 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:64 Encephalitis (from Ancient Greek ?????????, enk more...

Related Diseases for Encephalitis

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Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 522)
idRelated DiseaseScoreTop Affiliating Genes
1limbic encephalitis32.4GAD1
2tick-borne encephalitis32.3RAF1
3st. louis encephalitis32.2RAF1
4herpes simplex31.6TLR3, UNC93B1, CXCL10, GAD1, TAT
5rasmussen encephalitis31.5GAD1, GSR
6yellow fever31.1RAF1
7pneumonia30.9TLR3, CXCL10, CCL2
8west nile fever30.8RAF1
9hemorrhagic fever30.8CD40LG
10newcastle disease30.5IVNS1ABP, CXCL10
11hepatitis30.4TAT, GSR, CXCL10
12demyelinating disease30.4IFNG, CCL2
13dementia30.4TAT, GSR, CXCL10
14malaria30.3TAT, GSR, IFNG
15arthritis30.3IVNS1ABP, TLR3, CXCL10, CCL2, IFNG, TAT
16hiv-130.2TAT, RAF1, GSR, CXCL10
17uveitis30.2CXCL10, CCL2, IFNG
18systemic lupus erythematosus30.2CXCL10, CCL2, IFNG, CD40LG
19influenza30.1IVNS1ABP, TLR3, CXCL10, IFNG, TAT, TRAF3
20dengue hemorrhagic fever30.1CD40LG, IVNS1ABP
21vasculitis30.0CD40LG, TAT, CCL2
22leukemia29.9FER, IFNG, RAF1, CD40LG, TRAF3
23tetanus29.8IFNG, GAD1, TAT, CD40LG
24ulcerative colitis29.8IFNG, CXCL10, TLR3
25graves' disease29.7CXCL10, LGALS3, IFNG, GAD1
26adenocarcinoma29.6CXCL10, LGALS3, RAF1, TAT, TRAF3
27tuberculosis29.5TAT, GSR, IFNG, CXCL10
28hepatitis c29.4TLR3, CXCL10, IFNG, GSR, CD40LG
29rheumatoid arthritis29.4CD40LG, IFNG, CCL2, CXCL10, TLR3, IVNS1ABP
30prostate cancer29.4FER, CXCL10, LGALS3, GSR, RAF1
31breast cancer29.3CXCL10, LGALS3, GSR, RAF1, GAD1, TRAF3
32hepatitis b29.2TLR3, CXCL10, IFNG, GSR, RAF1, TAT
33asthma29.1TLR3, CXCL10, CCL2, IFNG, GSR, RAF1
34ischemia29.0LGALS3, GSR, RAF1, GAD1, TAT
35malignant glioma28.8LGALS3, GSR, RAF1, TAT
36japanese encephalitis11.2
37herpes simplex encephalitis11.1
38venezuelan equine encephalitis11.1
39viral encephalitis11.0
40eastern equine encephalitis11.0
41western equine encephalitis10.9
42murray valley encephalitis10.9
43autoimmune encephalitis10.7
44west nile encephalitis10.7
45west nile virus10.7
46meningitis10.6
47neuronitis10.6
48la crosse encephalitis10.6
49neonatal herpes10.6
50granulomatous amebic encephalitis10.5

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to encephalitis

Symptoms for Encephalitis

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Drugs & Therapeutics for Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Encephalitis

Search NIH Clinical Center for Encephalitis

Genetic Tests for Encephalitis

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Anatomical Context for Encephalitis

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MalaCards organs/tissues related to Encephalitis:

31
Brain, T cells, Testes, Spinal cord, Lung, Temporal lobe, B cells, Monocytes, Kidney, Cortex, Myeloid, Bone, Liver, Eye, Breast, Skin, Endothelial, Pituitary, Bone marrow, Spleen, Cerebellum, Colon, Thyroid, Prostate, Neutrophil, Salivary gland, Occipital lobe, Lymph node, Heart, Pancreas, Ovary, Testis, Tonsil, Olfactory bulb, Thalamus, Amygdala, Trigeminal ganglion

Animal Models for Encephalitis or affiliated genes

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Publications for Encephalitis

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Articles related to Encephalitis:

(show top 50)    (show all 4933)
idTitleAuthorsYear
1
Acute hemorrhagic encephalitis: An unusual presentation of dengue viral infection. (25709166)
2015
2
C-65Neurocognitive Rehabilitation of a West Nile Encephalitis Survivor. (25176908)
2014
3
Encephalitis claims 13 more lives as Indian government launches vaccine against one cause of the outbreak. (24128978)
2013
4
Tick-borne encephalitis virus, Zealand, Denmark, 2011. (23764123)
2013
5
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
6
Magnetic resonance imaging findings in a case of congenital rubella encephalitis. (24489572)
2013
7
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
8
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
9
Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. (22787234)
2012
10
Low coverage and predictors of vaccination uptake against tick-borne encephalitis in Slovenia. (21398380)
2012
11
Pathogenic and vaccine strains of Japanese encephalitis virus elicit different levels of human macrophage effector functions. (22729616)
2012
12
Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011. (22958609)
2012
13
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
14
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
15
Serosurveillance for Japanese encephalitis and West Nile viruses in resident birds in Hawai'i. (20688669)
2010
16
ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV) (24479198)
2010
17
Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem. (20544248)
2010
18
Viral encephalitis associated with pandemic 2009 (H1N1) influenza A. (22767664)
2010
19
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
20
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
21
Tracking eastern equine encephalitis virus perpetuation in the northeastern United States by phylogenetic analysis. (18689638)
2008
22
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
23
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
24
Development of immunofiltration assay by light addressable potentiometric sensor with genetically biotinylated recombinant antibody for rapid identification of Venezuelan equine encephalitis virus. (15251409)
2004
25
Differential diagnosis of West Nile encephalitis. (15353960)
2004
26
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. (14687719)
2003
27
Viral encephalitis: familiar infections and emerging pathogens. (11853816)
2002
28
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
29
Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12. (12388728)
2002
30
First case of Nipah virus encephalitis in Singapore. (11480479)
2001
31
Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. (10841661)
2000
32
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
33
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
34
Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. (9434729)
1997
35
Two possible mechanisms for survival and initiation of Murray Valley encephalitis virus activity in the Kimberley region of Western Australia. (7625542)
1995
36
Experimental transmission of eastern equine encephalitis virus and Highlands J virus via semen of infected tom turkeys. (7677655)
1995
37
Induction of encephalitis in SJL mice by intranasal infection with herpes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. (1849158)
1991
38
Kluver Bucy syndrome with severe amnesia secondary to herpes encephalitis. (3203279)
1988
39
Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986. (2852209)
1988
40
Non-herpes simplex encephalitis is early exclusion of herpes simplex etiology possible? (2824204)
1987
41
Distribution of dopa-oxidase isozymes among mosquito vectors of viral encephalitis. (3917888)
1985
42
Powassan viral encephalitis: a review and experimental studies in the horse and rabbit. (2996203)
1985
43
Immunoglobulins in the cerebrospinal fluid: changes during acute viral encephalitis in mice. (7451970)
1981
44
Viral encephalitis in the OR. (227326)
1979
45
Quantitative studies of the vector competence of Aedes aegypti, Culex annulirostris and other mosquitoes (Diptera: Culicidae) with Murray Valley encephalitis and other Queensland arboviruses. (42801)
1979
46
Eastern equine encephalitis in Massachusetts, 1957-1976. A prospective study centered upon analyses of mosquitoes. (23676)
1978
47
Preparation of inactivated St. Louis encephalitis virus vaccine from hamster kidney cell culture. (5924439)
1966
48
ISOLATIONS OF ST. LOUIS ENCEPHALITIS VIRUS FROM DOMESTIC PIGEONS, COLUMBA LIVIA. (14159988)
1964
49
Development and persistence of western equine encephalitis virus antibodies in experimentally infected pigeons. (13437685)
1957
50
Polyradiculopathy in man produced by St. Louis encephalitis virus (SLE). (13076770)
1953

Variations for Encephalitis

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Expression for genes affiliated with Encephalitis

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Search GEO for disease gene expression data for Encephalitis.

Pathways for genes affiliated with Encephalitis

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Pathways related to Encephalitis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0UNC93B1, TLR3
210.0TRAF3, IFNG
39.9CD40LG, TRAF3
49.7TRAF3, CCL2, CXCL10
59.6IFNG, CCL2, CD40LG
6
Show member pathways
thioredoxin pathway36
9.6GSR, IFNG, CCL2
7
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.6CCL2, RAF1, TRAF3
8
Show member pathways
9.6RAF1, IFNG, TRAF3
99.5TRAF3, TICAM1, TLR3
10
Show member pathways
9.5TLR3, TICAM1, TRAF3
11
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.5CD40LG, RAF1, IFNG
129.4TRAF3, CD40LG, TICAM1
139.4IFNG, LGALS3, CCL2, CXCL10
14
Show member pathways
9.3TREX1, TLR3, TICAM1, CXCL10
159.1TRAF3, TLR3, TICAM1, RAF1
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.1TICAM1, TRAF3, TLR3, RAF1
17
Show member pathways
8.9CCL2, RAF1, IFNG, CD40LG, CXCL10
18
Show member pathways
8.7CCL2, FER, RAF1, CXCL10
19
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.3CCL2, TRAF3, RAF1, IFNG, CXCL10, TICAM1
20
Show member pathways
7.8CCL2, IVNS1ABP, CXCL10, IFNG, TLR3, TICAM1

Compounds for genes affiliated with Encephalitis

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Compounds related to Encephalitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1polyinosinic-polycytidylic acid4410.0TLR3, IFNG, CXCL10
2il-124410.0CD40LG, IFNG, CCL2
3il 104410.0CXCL10, IFNG, CCL2
4gsno449.9CXCL10, IFNG, GSR
5tarc449.9IFNG, CCL2, CXCL10
6ifn-alpha449.9TLR3, IFNG, CXCL10
7ribavirin44 50 1111.8CD40LG, CXCL10, IFNG
8valproate449.7GAD1, CD40LG, GSR
9neopterin449.7IFNG, CD40LG, CXCL10
10poly(i-c)449.7IFNG, TLR3, CXCL10, TICAM1
11allergens449.7IFNG, CXCL10, LGALS3, CD40LG
122,5-oligoadenylate449.6IFNG, TAT, TLR3, CXCL10
13herbimycin a44 6010.6CD40LG, RAF1, CCL2, IFNG
14ccl344 2810.6TAT, IFNG, CCL2, CXCL10
15endotoxin449.5CXCL10, CD40LG, IFNG, CCL2, TLR3
16pdtc449.4CCL2, IFNG, RAF1
17gnrh449.4GSR, GAD1, RAF1, CCL2
18wortmannin449.4LGALS3, CXCL10, TLR3, CCL2, RAF1
19chloroquine44 1 50 28 1113.3GSR, TAT, RAF1, CXCL10
20l-glutamic acid28 24 1111.3TAT, GAD1, GSR
21n acetylcysteine449.2CD40LG, RAF1, GSR, CCL2
22creatinine449.2CD40LG, CXCL10, CCL2, GSR, GAD1
23nitric oxide44 24 1111.2LGALS3, CCL2, IFNG, GAD1, TLR3, CXCL10
24cisplatin44 50 60 1112.1CD40LG, LGALS3, CCL2, GSR, RAF1
25agar449.0TAT, CCL2, CD40LG, LGALS3, RAF1
26nmda44 2810.0GAD1, GSR, CCL2, TAT
27butyrate449.0LGALS3, IFNG, RAF1, TAT
28glutamine449.0LGALS3, CCL2, RAF1, TAT, GAD1
29cyclosporin a44 28 6011.0CD40LG, GAD1, IFNG, TAT, RAF1
30cycloheximide449.0RAF1, IFNG, CXCL10, CCL2, TAT
31pge2449.0RAF1, CD40LG, CCL2, CXCL10, GSR, IFNG
32indomethacin44 28 60 1112.0RAF1, IFNG, CD40LG, TAT, GSR
33histamine44 28 2410.8RAF1, CXCL10, IFNG, CCL2, TAT, CD40LG
34oxygen44 249.8GAD1, TRAF3, GSR, CCL2, LGALS3, TAT
35fibrinogen448.7CD40LG, TAT, CCL2, LGALS3
36adenylate448.7TAT, CXCL10, GSR, CD40LG, IVNS1ABP
37oligonucleotide448.7GAD1, LGALS3, TAT, TLR3, TREX1, TRAF3
38dexamethasone44 50 28 1111.6TAT, CXCL10, CCL2, IFNG, RAF1, TLR3
39rantes448.6CCL2, TLR3, TICAM1, TAT, IFNG, CXCL10
40estrogen448.5CD40LG, TAT, CXCL10, LGALS3, RAF1, GSR
41arginine448.5LGALS3, CCL2, IFNG, GSR, GAD1, CD40LG
42vegf448.5RAF1, TAT, IFNG, CCL2, LGALS3, CXCL10
43retinoic acid44 249.5TAT, TLR3, RAF1, LGALS3, CXCL10, IFNG
44aspartate448.5GAD1, RAF1, TRAF3, CD40LG, TAT, GSR
45genistein44 28 60 1 24 1113.5CXCL10, CCL2, IFNG, GSR, TAT, RAF1
46phosphatidylinositol448.3CXCL10, TLR3, FER, LGALS3, CCL2, RAF1
47cysteine448.3LGALS3, TAT, IFNG, GSR, RAF1, GAD1
48alanine448.1GSR, RAF1, GAD1, CD40LG, TRAF3, CXCL10
49serine448.1CD40LG, LGALS3, TAT, TRAF3, RAF1, CCL2
50tyrosine447.7TAT, GAD1, RAF1, TRAF3, FER, CXCL10

GO Terms for genes affiliated with Encephalitis

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Cellular components related to Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6CD40LG, IFNG, CXCL10
2extracellular spaceGO:00056158.7CD40LG, IFNG, CCL2, LGALS3, CXCL10

Biological processes related to Encephalitis according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-betaGO:003545810.3TREX1, TLR3
2macrophage chemotaxisGO:004824610.1CCL2, LGALS3
3positive regulation of interferon-beta biosynthetic processGO:004535910.1TLR3, TICAM1
4monocyte chemotaxisGO:000254810.1CCL2, LGALS3
5cellular response to interferon-gammaGO:007134610.1CCL2, TLR3
6positive regulation of interleukin-12 productionGO:003273510.0TLR3, IFNG, CD40LG
7neutrophil chemotaxisGO:00305939.9LGALS3, CCL2, IFNG
8positive regulation of chemokine biosynthetic processGO:00450809.9IFNG, TLR3, TICAM1
9positive regulation of tumor necrosis factor productionGO:00327609.8IFNG, TLR3, TICAM1
10TRIF-dependent toll-like receptor signaling pathwayGO:00356669.8TICAM1, TLR3, TRAF3
11response to gamma radiationGO:00103329.8CCL2, CXCL10
12MyD88-independent toll-like receptor signaling pathwayGO:00027569.8TLR3, TICAM1, TRAF3
13toll-like receptor 4 signaling pathwayGO:00341429.8TLR3, TRAF3, TICAM1
14cell surface receptor signaling pathwayGO:00071669.8CCL2, IFNG, CXCL10
15lipopolysaccharide-mediated signaling pathwayGO:00316639.8TICAM1, CCL2
16positive regulation of nitric oxide biosynthetic processGO:00454299.8TICAM1, IFNG
17toll-like receptor 3 signaling pathwayGO:00341389.7TICAM1, TLR3, UNC93B1, TRAF3
18toll-like receptor signaling pathwayGO:00022249.7TRAF3, TLR3, TICAM1, UNC93B1
19chemokine-mediated signaling pathwayGO:00700989.6CCL2, CXCL10
20defense response to virusGO:00516079.4CXCL10, TICAM1, IFNG, TLR3, UNC93B1
21chemotaxisGO:00069359.4CCL2, FER, CXCL10
22inflammatory responseGO:00069549.3CD40LG, TLR3, TICAM1, CXCL10, CCL2
23signal transductionGO:00071659.2TLR3, TRAF3, CXCL10, RAF1, CCL2
24positive regulation of NF-kappaB transcription factor activityGO:00510929.2TICAM1, FER, TLR3
25innate immune responseGO:00450878.7TRAF3, TREX1, TLR3, UNC93B1, TICAM1, LGALS3

Sources for Encephalitis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet