MCID: ENC004
MIFTS: 65

Encephalitis malady

Neuronal diseases, Infectious diseases, Rare diseases categories
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Summaries for Encephalitis

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8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Encephalitis is an inflammation of the brain. usually the cause is a viral infection, but bacteria can also cause it. it can be mild or severe. most cases are mild. you may have flu-like symptoms. with a mild case, you may just need rest, plenty of fluids, and a pain reliever. severe cases need immediate treatment. symptoms of severe cases include severe headache sudden fever drowsiness vomiting confusion seizures in babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. severe cases may require a stay in the hospital. treatments include oral and intravenous medicines to reduce inflammation and treat infection. patients with breathing difficulties may need artificial respiration. some people may need physical, speech, and occupational therapy once the illness is under control. nih: national institute of neurological disorders and stroke

MalaCards: Encephalitis is related to tick-borne encephalitis and limbic encephalitis. An important gene associated with Encephalitis is UNC93B1 (unc-93 homolog B1 (C. elegans)), and among its related pathways are Trafficking and processing of endosomal TLR and OX40 Pathway. The compounds polyinosinic-polycytidylic acid and il-12 have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:8 Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures.

NINDS:44 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:65 Encephalitis (from Ancient Greek ?????????, enk more...

Aliases & Classifications for Encephalitis

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8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Related Diseases for Encephalitis

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17GeneCards, 18GeneDecks
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Diseases in the Viral Encephalitis family:

encephalitis Autoimmune Encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 516)
idRelated DiseaseScoreTop Affiliating Genes
1tick-borne encephalitis31.8RAF1
2limbic encephalitis31.7GAD1
3st. louis encephalitis31.7RAF1
4herpes simplex31.7TAT, TLR3, UNC93B1, CXCL10, GAD1
5rasmussen encephalitis31.2GSR, GAD1
6west nile encephalitis31.1RAF1
7encephalomyelitis30.9CXCL10, CCL2, IFNG, GAD1
8yellow fever30.6RAF1
9pneumonia30.5TLR3, CCL2, CXCL10
10arthritis30.5CCL2, IVNS1ABP, TLR3, CXCL10, IFNG, TAT
11multiple sclerosis30.4IFNG, CXCL10, CCL2, GSR, GAD1, TLR3
12influenza30.3TAT, IVNS1ABP, TLR3, CXCL10, IFNG, TRAF3
13hemorrhagic fever30.3CD40LG
14hepatitis30.3GSR, TAT, CXCL10
15dementia30.3CXCL10, GSR, TAT
16malaria30.1GSR, IFNG, TAT
17newcastle disease30.1CXCL10, IVNS1ABP
18leukemia30.1TRAF3, CD40LG, IFNG, FER, RAF1
19systemic lupus erythematosus30.0CXCL10, CCL2, CD40LG, IFNG
20adenocarcinoma30.0RAF1, CXCL10, LGALS3, TAT, TRAF3
21breast cancer29.9GSR, LGALS3, RAF1, GAD1, CXCL10, TRAF3
22tetanus29.8GAD1, IFNG, TAT, CD40LG
23dengue hemorrhagic fever29.7IVNS1ABP, CD40LG
24prostate cancer29.7FER, RAF1, CXCL10, GSR, LGALS3
25hepatitis b29.7TLR3, TAT, GSR, IFNG, CXCL10, RAF1
26autoimmune thyroiditis29.7GAD1, IFNG, LGALS3
27vasculitis29.7TAT, CD40LG, CCL2
28ulcerative colitis29.7TLR3, CXCL10, IFNG
29graves' disease29.6LGALS3, IFNG, GAD1, CXCL10
30tuberculosis29.6TAT, CXCL10, IFNG, GSR
31hepatitis c29.6GSR, CD40LG, CXCL10, IFNG, TLR3
32rheumatoid arthritis29.6CCL2, CD40LG, CXCL10, IFNG, TLR3, IVNS1ABP
33asthma29.5CXCL10, CCL2, TLR3, IFNG, RAF1, GSR
34ischemia29.5GAD1, RAF1, LGALS3, GSR, TAT
35malignant glioma29.4GSR, LGALS3, TAT, RAF1
36japanese encephalitis11.1
37herpes simplex encephalitis11.1
38venezuelan equine encephalitis11.1
39viral encephalitis11.0
40eastern equine encephalitis10.9
41western equine encephalitis10.9
42murray valley encephalitis10.9
43west nile virus10.7
44autoimmune encephalitis10.6
45meningitis10.6
46la crosse encephalitis10.6
47neuronitis10.6
48neonatal herpes10.5
49cerebritis10.5
50granulomatous amebic encephalitis10.5

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to encephalitis

Symptoms for Encephalitis

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Drugs & Therapeutics for Encephalitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Encephalitis

Search NIH Clinical Center for Encephalitis

Genetic Tests for Encephalitis

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Anatomical Context for Encephalitis

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33MalaCards
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MalaCards organs/tissues related to Encephalitis:

33
Brain, T cells, Testes, Spinal cord, Lung, Temporal lobe, B cells, Monocytes, Kidney, Cortex, Myeloid, Bone, Skin, Pituitary, Breast, Eye, Liver, Thyroid, Endothelial, Spleen, Bone marrow, Colon, Prostate, Cerebellum, Salivary gland, Ovary, Lymph node, Pancreas, Heart, Occipital lobe, Olfactory bulb, Thalamus, Trigeminal ganglion, Tonsil

Animal Models for Encephalitis or affiliated genes

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37MGI
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Publications for Encephalitis

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52PubMed
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Articles related to Encephalitis:

(show top 50)    (show all 4554)
idTitleAuthorsYear
1
Encephalitis claims 13 more lives as Indian government launches vaccine against one cause of the outbreak. (24128978)
2013
2
Tick-borne encephalitis virus, Zealand, Denmark, 2011. (23764123)
2013
3
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
4
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
5
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
6
Serological evidence for eastern equine encephalitis virus activity in white-tailed deer, Odocoileus virginianus, in Vermont, 2010. (23208886)
2013
7
Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. (22787234)
2012
8
Low coverage and predictors of vaccination uptake against tick-borne encephalitis in Slovenia. (21398380)
2012
9
Pathogenic and vaccine strains of Japanese encephalitis virus elicit different levels of human macrophage effector functions. (22729616)
2012
10
Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011. (22958609)
2012
11
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
12
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
13
Serosurveillance for Japanese encephalitis and West Nile viruses in resident birds in Hawai'i. (20688669)
2010
14
Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem. (20544248)
2010
15
Viral encephalitis associated with pandemic 2009 (H1N1) influenza A. (22767664)
2010
16
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
17
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
18
Tracking eastern equine encephalitis virus perpetuation in the northeastern United States by phylogenetic analysis. (18689638)
2008
19
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
20
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
21
Rehabilitation of West Nile Fever (WNF) encephalitis in elderly. (15911034)
2005
22
Development of immunofiltration assay by light addressable potentiometric sensor with genetically biotinylated recombinant antibody for rapid identification of Venezuelan equine encephalitis virus. (15251409)
2004
23
Differential diagnosis of West Nile encephalitis. (15353960)
2004
24
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. (14687719)
2003
25
Viral encephalitis: familiar infections and emerging pathogens. (11853816)
2002
26
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
27
Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12. (12388728)
2002
28
Tick-borne encephalitis virus NS1 glycoprotein during acute and persistent infection of cells. (11410315)
2001
29
First case of Nipah virus encephalitis in Singapore. (11480479)
2001
30
Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. (10841661)
2000
31
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
32
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
33
Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. (9434729)
1997
34
Two possible mechanisms for survival and initiation of Murray Valley encephalitis virus activity in the Kimberley region of Western Australia. (7625542)
1995
35
Experimental transmission of eastern equine encephalitis virus and Highlands J virus via semen of infected tom turkeys. (7677655)
1995
36
Induction of encephalitis in SJL mice by intranasal infection with herpes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. (1849158)
1991
37
Kluver Bucy syndrome with severe amnesia secondary to herpes encephalitis. (3203279)
1988
38
Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986. (2852209)
1988
39
Non-herpes simplex encephalitis is early exclusion of herpes simplex etiology possible? (2824204)
1987
40
Distribution of dopa-oxidase isozymes among mosquito vectors of viral encephalitis. (3917888)
1985
41
Powassan viral encephalitis: a review and experimental studies in the horse and rabbit. (2996203)
1985
42
Immunoglobulins in the cerebrospinal fluid: changes during acute viral encephalitis in mice. (7451970)
1981
43
Virion polypeptide heterogeneity among virulent and avirulent strains of eastern equine encephalitis (EEE) virus. (6268022)
1981
44
Viral encephalitis in the OR. (227326)
1979
45
Quantitative studies of the vector competence of Aedes aegypti, Culex annulirostris and other mosquitoes (Diptera: Culicidae) with Murray Valley encephalitis and other Queensland arboviruses. (42801)
1979
46
Eastern equine encephalitis in Massachusetts, 1957-1976. A prospective study centered upon analyses of mosquitoes. (23676)
1978
47
Preparation of inactivated St. Louis encephalitis virus vaccine from hamster kidney cell culture. (5924439)
1966
48
ISOLATIONS OF ST. LOUIS ENCEPHALITIS VIRUS FROM DOMESTIC PIGEONS, COLUMBA LIVIA. (14159988)
1964
49
Development and persistence of western equine encephalitis virus antibodies in experimentally infected pigeons. (13437685)
1957
50
Polyradiculopathy in man produced by St. Louis encephalitis virus (SLE). (13076770)
1953

Variations for Encephalitis

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Expression for genes affiliated with Encephalitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalitis

Search GEO for disease gene expression data for Encephalitis.

Pathways for genes affiliated with Encephalitis

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50PathCards, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 5Cell Signaling Technology, 54R&D Systems
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Pathways related to Encephalitis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TLR3, UNC93B1
210.0TRAF3, IFNG
39.9TRAF3, CD40LG
49.7TRAF3, CCL2, CXCL10
59.6CD40LG, IFNG, CCL2
6
Show member pathways
thioredoxin pathway38
9.6GSR, IFNG, CCL2
7
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.6CCL2, RAF1, TRAF3
8
Show member pathways
9.6TRAF3, RAF1, IFNG
9
Show member pathways
9.5TRAF3, TICAM1, TLR3
109.5TLR3, TICAM1, TRAF3
11
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.5CD40LG, RAF1, IFNG
129.4TRAF3, CD40LG, TICAM1
139.4CXCL10, LGALS3, CCL2, IFNG
14
Show member pathways
9.3TREX1, CXCL10, TICAM1, TLR3
159.1TLR3, TICAM1, RAF1, TRAF3
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1TLR3, TICAM1, RAF1, TRAF3
17
Show member pathways
8.9CXCL10, CCL2, IFNG, RAF1, CD40LG
18
Show member pathways
8.7FER, CXCL10, CCL2, RAF1
19
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.3TLR3, TICAM1, CXCL10, CCL2, IFNG, RAF1
20
Show member pathways
7.8TRAF3, IVNS1ABP, TLR3, TICAM1, CXCL10, CCL2

Compounds for genes affiliated with Encephalitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1polyinosinic-polycytidylic acid4510.0TLR3, CXCL10, IFNG
2il-124510.0CCL2, IFNG, CD40LG
3il 104510.0IFNG, CCL2, CXCL10
4gsno459.9GSR, IFNG, CXCL10
5tarc459.9CXCL10, CCL2, IFNG
6ifn-alpha459.9IFNG, CXCL10, TLR3
7ribavirin45 51 1111.8CD40LG, IFNG, CXCL10
8valproate459.7GSR, GAD1, CD40LG
9neopterin459.7CD40LG, IFNG, CXCL10
10poly(i-c)459.7TLR3, TICAM1, CXCL10, IFNG
11allergens459.7CD40LG, IFNG, LGALS3, CXCL10
122,5-oligoadenylate459.6TLR3, CXCL10, IFNG, TAT
13herbimycin a45 6110.6CD40LG, RAF1, IFNG, CCL2
14ccl345 2910.6CXCL10, CCL2, IFNG, TAT
15endotoxin459.5TLR3, CXCL10, CCL2, IFNG, CD40LG
16pdtc459.4CCL2, IFNG, RAF1
17gnrh459.4CCL2, GSR, RAF1, GAD1
18wortmannin459.4TLR3, CXCL10, LGALS3, CCL2, RAF1
19chloroquine45 3 51 29 1113.3TAT, RAF1, GSR, CXCL10
20l-glutamic acid29 24 1111.3TAT, GAD1, GSR
21n acetylcysteine459.2CCL2, GSR, RAF1, CD40LG
22creatinine459.2CXCL10, CCL2, GSR, GAD1, CD40LG
23nitric oxide45 24 1111.2TLR3, CXCL10, LGALS3, CCL2, IFNG, GAD1
24cisplatin45 51 61 1112.1CD40LG, RAF1, GSR, CCL2, LGALS3
25agar459.0LGALS3, CCL2, RAF1, TAT, CD40LG
26nmda45 2910.0TAT, GAD1, GSR, CCL2
27butyrate459.0LGALS3, IFNG, RAF1, TAT
28glutamine459.0LGALS3, CCL2, RAF1, GAD1, TAT
29cyclosporin a45 29 6111.0IFNG, RAF1, GAD1, TAT, CD40LG
30cycloheximide459.0TAT, RAF1, IFNG, CCL2, CXCL10
31pge2459.0CXCL10, CCL2, IFNG, GSR, RAF1, CD40LG
32indomethacin45 29 61 1112.0IFNG, GSR, RAF1, TAT, CD40LG
33histamine45 29 2410.8CXCL10, CCL2, IFNG, RAF1, TAT, CD40LG
34oxygen45 249.8LGALS3, CCL2, GSR, GAD1, TAT, TRAF3
35fibrinogen458.7CD40LG, TAT, CCL2, LGALS3
36adenylate458.7IVNS1ABP, CXCL10, GSR, TAT, CD40LG
37oligonucleotide458.7TLR3, LGALS3, RAF1, GAD1, TAT, TREX1
38dexamethasone45 51 29 1111.6TLR3, CXCL10, CCL2, IFNG, RAF1, TAT
39rantes458.6CD40LG, TLR3, TICAM1, CXCL10, CCL2, IFNG
40estrogen458.5CXCL10, LGALS3, GSR, RAF1, TAT, CD40LG
41arginine458.5LGALS3, CCL2, IFNG, GSR, GAD1, TAT
42vegf458.5CXCL10, LGALS3, CCL2, IFNG, RAF1, TAT
43retinoic acid45 249.5TLR3, CXCL10, LGALS3, IFNG, RAF1, TAT
44aspartate458.5CCL2, GSR, RAF1, GAD1, TAT, CD40LG
45genistein45 29 61 3 24 1113.5CXCL10, CCL2, IFNG, GSR, RAF1, TAT
46phosphatidylinositol458.3TLR3, FER, CXCL10, LGALS3, CCL2, RAF1
47cysteine458.3LGALS3, IFNG, GSR, RAF1, GAD1, TAT
48alanine458.1CXCL10, LGALS3, GSR, RAF1, GAD1, TAT
49serine458.1TLR3, TICAM1, LGALS3, CCL2, RAF1, TAT
50tyrosine457.7TLR3, FER, CXCL10, LGALS3, RAF1, GAD1

GO Terms for genes affiliated with Encephalitis

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16Gene Ontology
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Cellular components related to Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6CD40LG, IFNG, CXCL10
2extracellular spaceGO:0056158.7CD40LG, IFNG, CCL2, LGALS3, CXCL10

Biological processes related to Encephalitis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-betaGO:03545810.3TLR3, TREX1
2macrophage chemotaxisGO:04824610.1CCL2, LGALS3
3positive regulation of interferon-beta biosynthetic processGO:04535910.1TICAM1, TLR3
4monocyte chemotaxisGO:00254810.1LGALS3, CCL2
5cellular response to interferon-gammaGO:07134610.1TLR3, CCL2
6positive regulation of interleukin-12 productionGO:03273510.0CD40LG, IFNG, TLR3
7neutrophil chemotaxisGO:0305939.9IFNG, CCL2, LGALS3
8positive regulation of chemokine biosynthetic processGO:0450809.9IFNG, TICAM1, TLR3
9positive regulation of tumor necrosis factor productionGO:0327609.8TLR3, TICAM1, IFNG
10TRIF-dependent toll-like receptor signaling pathwayGO:0356669.8TLR3, TICAM1, TRAF3
11response to gamma radiationGO:0103329.8CCL2, CXCL10
12MyD88-independent toll-like receptor signaling pathwayGO:0027569.8TRAF3, TICAM1, TLR3
13toll-like receptor 4 signaling pathwayGO:0341429.8TRAF3, TICAM1, TLR3
14cell surface receptor signaling pathwayGO:0071669.8IFNG, CCL2, CXCL10
15lipopolysaccharide-mediated signaling pathwayGO:0316639.8CCL2, TICAM1
16positive regulation of nitric oxide biosynthetic processGO:0454299.8IFNG, TICAM1
17toll-like receptor 3 signaling pathwayGO:0341389.7TLR3, UNC93B1, TICAM1, TRAF3
18toll-like receptor signaling pathwayGO:0022249.7TLR3, UNC93B1, TICAM1, TRAF3
19chemokine-mediated signaling pathwayGO:0700989.6CCL2, CXCL10
20defense response to virusGO:0516079.4IFNG, CXCL10, TICAM1, UNC93B1, TLR3
21chemotaxisGO:0069359.4FER, CXCL10, CCL2
22inflammatory responseGO:0069549.3TLR3, TICAM1, CXCL10, CCL2, CD40LG
23signal transductionGO:0071659.2TLR3, CXCL10, CCL2, RAF1, TRAF3
24positive regulation of NF-kappaB transcription factor activityGO:0510929.2FER, TICAM1, TLR3
25innate immune responseGO:0450878.7TLR3, UNC93B1, TICAM1, LGALS3, RAF1, TREX1

Products for genes affiliated with Encephalitis

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Sources for Encephalitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet