MCID: ENC004
MIFTS: 64

Encephalitis malady

Neuronal diseases category

Summaries for Encephalitis

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8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Encephalitis is an inflammation of the brain. usually the cause is a viral infection, but bacteria can also cause it. it can be mild or severe. most cases are mild. you may have flu-like symptoms. with a mild case, you may just need rest, plenty of fluids, and a pain reliever. severe cases need immediate treatment. symptoms of severe cases include severe headache sudden fever drowsiness vomiting confusion seizures in babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. severe cases may require a stay in the hospital. treatments include oral and intravenous medicines to reduce inflammation and treat infection. patients with breathing difficulties may need artificial respiration. some people may need physical, speech, and occupational therapy once the illness is under control. nih: national institute of neurological disorders and stroke

MalaCards: Encephalitis is related to herpes simplex and tick-borne encephalitis. An important gene associated with Encephalitis is TREX1 (three prime repair exonuclease 1), and among its related pathways are Influenza A and Toll-like receptor signaling pathway. The compounds genistein and vegf have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Disease Ontology:8 Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. the usual cause is a viral infection, but bacteria can also cause it. cases can range from mild to severe. for mild cases, you could have flu-like symptoms. serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures.

NINDS:43 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:63 Encephalitis (from Ancient Greek ἐγκέφαλος, enképhalos “brain”, composed of ἐν, en,... more...

Aliases & Classifications for Encephalitis

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Related Diseases for Encephalitis

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17GeneCards, 18GeneDecks
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Diseases in the Viral Encephalitis family:

encephalitis Autoimmune Encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 486)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex31.6TLR3, IFNA1, UNC93B1, GAD1, CXCL10, TAT
2tick-borne encephalitis31.6RAF1
3st. louis encephalitis31.5RAF1
4venezuelan equine encephalitis31.5SH2D3C
5eastern equine encephalitis31.4SH2D3C
6west nile encephalitis31.2RAF1, STAB2
7meningitis30.9CXCL10
8la crosse encephalitis30.8STAB2
9encephalomyelitis30.8CCL2, IFNG, GAD1, CXCL10
10arthritis30.5CCL2, TLR3, IFNG, IVNS1ABP, CXCL10, TAT
11yellow fever30.4RAF1, PRNT
12measles30.4TLR3, CD40LG
13limbic encephalitis30.4GAD1
14multiple sclerosis30.4CCL2, TLR3, IFNG, IFNA1, GAD1, CXCL10
15influenza30.3TLR3, IFNG, IFNA1, IVNS1ABP, CXCL10, TAT
16rubella30.3CD40LG
17rasmussen encephalitis30.3GSR, GAD1
18pneumonia30.3CXCL10, TLR3, CCL2
19subacute sclerosing panencephalitis30.3IFNA1
20hepatitis30.2IFNA1, CXCL10, TAT, GSR
21dementia30.2GSR, TAT, CXCL10
22lyme disease30.1CD40LG, STAB2
23leukemia30.1IFNG, IFNA1, FER, CD40LG, RAF1
24breast cancer30.0GAD1, CXCL10, RAF1, GSR
25malaria30.0GSR, TAT, IFNG
26alzheimer's disease30.0TLR3, GAD1, RAF1, GSR
27acquired immunodeficiency syndrome30.0TAT, IFNA1
28myasthenia gravis30.0IFNG
29systemic lupus erythematosus29.9CCL2, IFNG, IFNA1, CD40LG, CXCL10
30thrombocytopenia29.9IFNA1, CD40LG, RAF1
31newcastle disease29.9IFNA1, IVNS1ABP, CXCL10
32lupus erythematosus29.9TREX1, CD40LG
33thyroiditis29.9IFNA1
34hypertension29.9CCL2
35acute leukemia29.9GSR
36tetanus29.8IFNG, GAD1, CD40LG, TAT
37hepatitis b29.8CXCL10, IFNA1, IFNG
38prostate cancer29.8GSR, RAF1, CXCL10, FER
39viral hepatitis29.8IFNA1
40viral infectious disease29.6CCL2, TLR3, IFNG, IFNA1, GAD1, IVNS1ABP
41hepatitis c29.6TLR3, IFNG, IFNA1, CD40LG, CXCL10, GSR
42asthma29.6CCL2, TLR3, IFNG, CXCL10, RAF1, GSR
43rheumatoid arthritis29.6CCL2, TLR3, IFNG, IVNS1ABP, CD40LG, CXCL10
44ischemia29.6GAD1, TAT, RAF1, GSR
45tuberculosis29.6GSR, TAT, CXCL10, IFNG
46graves' disease29.6CXCL10, GAD1, IFNG
47dengue hemorrhagic fever29.6CD40LG, IVNS1ABP
48cryoglobulinemia29.6CD40LG, IFNA1
49severe acute respiratory syndrome29.6CXCL10, SH2D3C
50glomerulonephritis29.6CD40LG, CCL2

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to encephalitis

Clinical Features for Encephalitis

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Drugs & Therapeutics for Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Encephalitis

Search NIH Clinical Center for Encephalitis

Search CenterWatch for Encephalitis

Genetic Tests for Encephalitis

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Anatomical Context for Encephalitis

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32MalaCards
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MalaCards organs/tissues related to Encephalitis:

32
Brain, T cells, Testes, Spinal cord, Temporal lobe, Lung, B cells, Monocytes, Kidney, Cortex, Myeloid, Bone, Liver, Eye, Breast, Skin, Pituitary, Spleen, Colon, Prostate, Endothelial, Thyroid, Bone marrow, Salivary gland, Cerebellum, Lymph node, Olfactory bulb, Occipital lobe, Thalamus, Ovary, Tonsil, Pancreas, Heart, Amygdala, Trigeminal ganglion

Animal Models for Encephalitis or affiliated genes

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36MGI
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Publications for Encephalitis

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50PubMed
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Articles related to Encephalitis:

(show top 50)    (show all 4594)
idTitleAuthorsYear
1
Age-Related Susceptibility to Japanese Encephalitis Virus in Domestic Ducklings and Chicks. (24394476)
2014
2
Regional Impact of Climate on Japanese Encephalitis in Areas Located near the Three Gorges Dam. (24404159)
2014
3
A bio-nanocapsule containing envelope protein domain III of Japanese encephalitis virus protects mice against lethal Japanese encephalitis virus infection. (23773026)
2013
4
Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis. (24369299)
2013
5
Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes. (23074319)
2013
6
Rapid progression and brain atrophy in anti-AMPA receptor encephalitis. (23796872)
2013
7
In vitro inhibition of Japanese encephalitis virus replication by capsid-targeted virus inactivation. (23321201)
2013
8
Phase III clinical trials comparing the immunogenicity and safety of Vero cell-derived Japanese encephalitis vaccine ENCEVAC(R) with those of mouse brain-derived vaccine using the Beijing-1 strain. (24334689)
2013
9
New estimates of incidence of encephalitis in England. (23969035)
2013
10
ssICAM-1, IL-21 and IL-23 in patients with tick borne encephalitis and neuroborreliosis. (22705151)
2012
11
Eastern equine encephalitis: MRI findings in two patients. (22928238)
2012
12
Pertussis-associated encephalitis/encephalopathy with marked demyelination in an unimmunized child. (22795552)
2012
13
Host responses to live-attenuated Venezuelan equine encephalitis virus (TC-83): comparison of naA^ve, vaccine responder and nonresponder to TC-83 challenge in human peripheral blood mononuclear cells. (22617845)
2012
14
Myasthenia gravis appearing 18 years after resection of benign thymoma with subsequent limbic encephalitis. (22483854)
2012
15
Immunogenicity of Japanese encephalitis virus envelope protein by Hyphantria cunea nuclear polyhedrosis virus vector in guinea pig. (22544685)
2012
16
Evaluation of CXCL10, CXCL11, CXCL12 and CXCL13 chemokines in serum and cerebrospinal fluid in patients with tick borne encephalitis (TBE). (22008312)
2011
17
Risk factors for Japanese encephalitis: a case-control study. (20109262)
2010
18
In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases. (19170891)
2009
19
Replicon particles of Venezuelan equine encephalitis virus as a reductionist murine model for encephalitis. (19225006)
2009
20
Risk factors for Nipah virus encephalitis in Bangladesh. (18826814)
2008
21
Pitfalls in diagnosing limbic encephalitis - a case report. (18384457)
2008
22
Conference report of the 9th meeting of the International Scientific Working Group of Tick Borne Encephalitis (ISW TBE). Tick Borne Encephalitis: from epidemiology to current vaccination recommendations. (17977628)
2007
23
Complete inactivation of Venezuelan equine encephalitis virus by 1,5-iodonaphthylazide. (17493582)
2007
24
Structure and immunogenicity of alternative forms of the simian immunodeficiency virus gag protein expressed using Venezuelan equine encephalitis virus replicon particles. (17275057)
2007
25
Packaging the replicon RNA of the Far-Eastern subtype of tick-borne encephalitis virus into single-round infectious particles: development of a heterologous gene delivery system. (15917116)
2005
26
Tick-borne encephalitis. (12628808)
2003
27
First case of Nipah virus encephalitis in Singapore. (11480479)
2001
28
Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5' untranslated region. (11264360)
2001
29
(18)F-fluorodeoxyglucose positron emission tomography and MR imaging findings in Rasmussen encephalitis. (11498416)
2001
30
Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. (10841661)
2000
31
Expression of the two major envelope proteins of equine arteritis virus as a heterodimer is necessary for induction of neutralizing antibodies in mice immunized with recombinant Venezuelan equine encephalitis virus replicon particles. (11044106)
2000
32
Anomia as a symptom of herpes simplex encephalitis. (8362693)
1993
33
Herpes simplex encephalitis: a diagnostic and therapeutic reapprisal. (8300459)
1993
34
Molecular evidence for the origin of the widespread Venezuelan equine encephalitis epizootic of 1969 to 1972. (1469368)
1992
35
St. Louis encephalitis in Arkansas. (1517179)
1992
36
Immunoaffinity purification of the NS1 protein of Murray Valley encephalitis virus: selection of the appropriate ligand and optimal conditions for elution. (1648569)
1991
37
Herpes simplex encephalitis. Immunohistological demonstration of spread of virus via olfactory and trigeminal pathways after infection of facial skin in mice. (6379105)
1984
38
Behavior disturbances during recovery from herpes simplex encephalitis. (6481383)
1984
39
Postinfectious encephalopathy after treatment of herpes simplex encephalitis with acyclovir. (6728706)
1984
40
Comparative vector competence of Culex tarsalis and Culex quinquefasciatus from the coachella, imperial, and San Joaquin Valleys of California for St. Louis encephalitis virus. (6301301)
1983
41
Acute viral encephalitis. (6799055)
1981
42
Multiple cerebral hematoma and viral encephalitis. (7422119)
1980
43
Isolation of Mucambo virus, a member of the Venezuelan equine encephalitis virus complex in the State of SALo Paulo, Brasil. (675033)
1978
44
The 1964 outbreak of St. Louis encephalitis in the Delaware Valey. 2. Laboratory studies of cases and serologic diagnostic procedures. (4968057)
1968
45
ARTHROPOD-BORNE VIRUS INFECTIONS IN WESTERN NEW GUINEA. I. REPORT OF A CASE OF MURRAY VALLEY ENCEPHALITIS IN A PAPUAN WOMAN. (14317227)
1965
46
Maze performance of mature rats recovered from early postnatal infection with Murray Valley encephalitis virus. (13654571)
1959
47
Murray Valley encephalitis virus: preparation of an infective "ribonucleic acid" fraction. (13793450)
1959
48
Polyradiculopathy in man produced by St. Louis encephalitis virus (SLE). (13076770)
1953
49
The hemagglutinin of St. Louis encephalitis virus. II. Physico-chemical properties and nature of its reaction with erythrocytes. (13035119)
1953
50
Isolation of St. Louis encephalitis virus from the peripheral blood of a human subject. (21023178)
1946

Genetic Variations for Encephalitis

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Expression for genes affiliated with Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalitis

Search GEO for disease gene expression data for Encephalitis.

Pathways for genes affiliated with Encephalitis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 52R&D Systems, 12EMD Millipore
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Pathways related to Encephalitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3RAF1, TICAM1, CCL2, TLR3, IFNG, IFNA1
2
Hide members
11.2TICAM1, CCL2, TLR3, IFNG, IFNA1, CXCL10
3
Hide members
11.2TICAM1, TLR3, IFNG, IFNA1, UNC93B1, TREX1
4
Hide members
10.9IFNG, IFNA1, GAD1, CD40LG
5
Hide members
10.9TICAM1, TLR3, IFNA1, RAF1
610.9TICAM1, TLR3, IFNA1, RAF1
7
Hide members
10.9RAF1, FER, IFNA1, IFNG
810.8GSR, IFNG, CCL2
9
Hide members
10.8IFNA1, TREX1, CXCL10
10
Hide members
10.8RAF1, CXCL10, IFNA1
11
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.8IFNA1, TLR3, TICAM1
1210.7UNC93B1, TLR3

Compounds for genes affiliated with Encephalitis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1genistein44 28 59 2 11 2416.6CCL2, IFNG, CD40LG, CXCL10, TAT, RAF1
2vegf4411.6CCL2, IFNG, IFNA1, CD40LG, CXCL10, TAT
3alanine4411.6IFNA1, GAD1, CD40LG, CXCL10, TAT, RAF1
4retinoic acid44 2412.5TLR3, IFNG, IFNA1, CD40LG, CXCL10, TAT
5histamine44 28 2413.5CCL2, IFNG, CD40LG, CXCL10, TAT, RAF1
6pge24411.5CCL2, IFNG, CD40LG, CXCL10, RAF1, GSR
7cyclosporin a44 28 5913.5IFNG, IFNA1, GAD1, CD40LG, TAT, RAF1
82,5-oligoadenylate4411.4TLR3, IFNG, IFNA1, CXCL10, TAT
9poly(i-c)4411.4TICAM1, TLR3, IFNG, IFNA1, CXCL10
10ccl344 2812.4TAT, CXCL10, IFNA1, IFNG, CCL2
11chloroquine44 2 49 28 1115.4IFNA1, CXCL10, TAT, RAF1, GSR
12aspartate4411.4RAF1, TAT, CD40LG, GAD1, CCL2
13dexamethasone44 49 28 1114.4TLR3, IFNA1, CD40LG, TAT, RAF1
14arginine4411.4CCL2, IFNG, GAD1, CD40LG, TAT, GSR
15actinomycin d4411.3CCL2, IFNG, IFNA1, CD40LG, TAT
16il-124411.3CCL2, IFNG, IFNA1, CD40LG
17polyinosinic-polycytidylic acid4411.3TLR3, IFNG, IFNA1, CXCL10
18ifn-alpha4411.3TLR3, IFNG, IFNA1, CXCL10
19neopterin4411.3IFNG, IFNA1, CD40LG, CXCL10
20cisplatin44 49 59 1114.3CCL2, IFNA1, CD40LG, RAF1, GSR
21cycloheximide4411.2IFNA1, CXCL10, TAT, RAF1
22herbimycin a44 5912.2CCL2, IFNG, CD40LG, RAF1
23rantes4411.2CD40LG, IFNA1, IFNG
24creatinine4411.2CCL2, GAD1, CD40LG, CXCL10, GSR
25tacrolimus44 49 1113.2IFNG, IFNA1, CXCL10, RAF1
26imiquimod44 28 59 1114.2TLR3, IFNG, IFNA1
27prednisolone44 28 1113.1TAT, GAD1, IFNA1
28gsno4411.1GSR, CXCL10, IFNG
29mycophenolate mofetil44 49 1113.1IFNG, IFNA1, CD40LG
30valproate4411.1GSR, CD40LG, GAD1
31il 104411.1CXCL10, IFNG, CCL2
32ribavirin44 49 1113.1CD40LG, IFNG
33adenylate4411.1IVNS1ABP, CD40LG, CXCL10, TAT, GSR
34tarc4411.1CCL2, IFNG, CXCL10
35cycloferon4411.1IFNA1, IFNG
36gnrh4411.1GSR, RAF1, GAD1
37melphalan44 1112.0IFNG, IFNA1, GSR
38agar4411.0RAF1, TAT, CCL2
39endotoxin4411.0TLR3
40rituximab44 49 1113.0RAF1, CD40LG, IFNA1
41betaseron4411.0IFNA1, IFNG
42allergens4411.0IFNG, CD40LG, CXCL10
43indomethacin44 59 28 1114.0TAT
44resiquimod44 5911.8TLR3, IFNA1
453-hydroxyanthranilic acid44 2411.8IFNG, IFNA1
46n acetylcysteine4410.8GSR, RAF1, CD40LG, CCL2
47thalidomide44 49 59 1113.8IFNG, IFNA1, CD40LG
483-Sulfinoalanine11 2411.7GSR, GAD1
49pdtc4410.7CCL2, RAF1
50l-glutamic acid28 11 2412.5TAT, GSR, GAD1

GO Terms for genes affiliated with Encephalitis

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16Gene Ontology
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Cellular components related to Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9CXCL10, CD40LG, STAB2, IFNG

Biological processes related to Encephalitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160711.2CXCL10, UNC93B1, IFNG, TLR3, TICAM1
2inflammatory responseGO:00695411.1TICAM1, CCL2, TLR3, CD40LG, CXCL10
3positive regulation of chemokine biosynthetic processGO:04508011.0IFNG, TLR3, TICAM1
4positive regulation of interleukin-12 productionGO:03273511.0TLR3, IFNG, CD40LG
5innate immune responseGO:04508711.0TICAM1, TLR3, UNC93B1, TREX1, RAF1
6positive regulation of tumor necrosis factor productionGO:03276010.9IFNG, TLR3, TICAM1
7toll-like receptor 3 signaling pathwayGO:03413810.8UNC93B1, TLR3, TICAM1
8positive regulation of interferon-beta biosynthetic processGO:04535910.8TICAM1, TLR3
9positive regulation of NF-kappaB transcription factor activityGO:05109210.8FER, TLR3, TICAM1
10defense response to bacteriumGO:04274210.7TLR3, IFNG, STAB2
11toll-like receptor signaling pathwayGO:00222410.5UNC93B1, TLR3, TICAM1

Products for genes affiliated with Encephalitis

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  • Antibodies
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Sources for Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet