MCID: ENC005
MIFTS: 27

Encephalomalacia malady

Categories: Neuronal diseases

Aliases & Classifications for Encephalomalacia

Aliases & Descriptions for Encephalomalacia:

Name: Encephalomalacia 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2034
MeSH 42 D004678
NCIt 47 C98920
SNOMED-CT 64 58762006
UMLS 69 C0014068

Summaries for Encephalomalacia

MalaCards based summary : Encephalomalacia is related to porencephaly and cerebritis. An important gene associated with Encephalomalacia is MOCS1 (Molybdenum Cofactor Synthesis 1). The drugs Magnesium Sulfate and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and liver.

Related Diseases for Encephalomalacia

Diseases related to Encephalomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
id Related Disease Score Top Affiliating Genes
1 porencephaly 11.2
2 cerebritis 10.0
3 encephalitis 9.8
4 epilepsy 9.8
5 hydranencephaly 9.7
6 pancreatitis 9.7
7 herpes simplex 9.7
8 meningitis 9.7
9 muscular dystrophy 9.7
10 hyperprolactinemia 9.6
11 hyperammonemia 9.6
12 ornithine transcarbamylase deficiency 9.6
13 retinitis 9.6
14 anoxia 9.6
15 atherosclerosis 9.6
16 seizure disorder 9.6
17 cerebral hemorrhage 9.6
18 hepatitis 9.6
19 infertility 9.6
20 lennox-gastaut syndrome 9.6
21 cerebral lymphoma 9.6
22 lymphoma 9.6
23 neuronitis 9.6
24 partial optic atrophy 9.6
25 vasculitis 9.6
26 disseminated intravascular coagulation 9.6
27 rubella 9.6
28 hepatic coma 9.6
29 cerebral atherosclerosis 9.6
30 arteriosclerosis 9.6
31 congenital rubella 9.6
32 myocardial infarction 9.6
33 acute pancreatitis 9.6
34 herpes simplex encephalitis 9.6
35 bacteremia 9.6
36 ischemia 9.6
37 tuberculous meningitis 9.6

Graphical network of the top 20 diseases related to Encephalomalacia:



Diseases related to Encephalomalacia

Symptoms & Phenotypes for Encephalomalacia

Drugs & Therapeutics for Encephalomalacia

Drugs for Encephalomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3 7487-88-9 24083
2 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
3 Anesthetics Phase 4,Phase 3
4 Anti-Arrhythmia Agents Phase 4,Phase 3
5 Anticonvulsants Phase 4,Phase 3
6 calcium channel blockers Phase 4,Phase 3
7 Calcium, Dietary Phase 4,Phase 3
8 Central Nervous System Depressants Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
11
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
12 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
13 Hematinics Phase 3,Phase 1,Phase 2
14 Anti-Asthmatic Agents Phase 2, Phase 3
15 Antioxidants Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 Bronchodilator Agents Phase 2, Phase 3
18 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
19 Neurotransmitter Agents Phase 2, Phase 3
20 Protective Agents Phase 2, Phase 3
21 Respiratory System Agents Phase 2, Phase 3
22 Vasodilator Agents Phase 2, Phase 3
23 Acidophilus Nutraceutical Phase 3
24
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
25
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
26
Glycerol Approved, Experimental Phase 2 56-81-5 753
27
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
28
Butyric Acid Experimental Phase 2 107-92-6 264
29 Pharmaceutical Solutions Phase 1, Phase 2
30 Anti-Inflammatory Agents Phase 2,Phase 1
31 Cortisol succinate Phase 2
32 Hydrocortisone 17-butyrate 21-propionate Phase 2
33 Hydrocortisone acetate Phase 2
34 Hydrocortisone-17-butyrate Phase 2
35 Analgesics, Non-Narcotic Phase 1, Phase 2
36 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
37 Antirheumatic Agents Phase 1, Phase 2
38 Cyclooxygenase Inhibitors Phase 1, Phase 2
39 Calcium polycarbophil Phase 2
40 Carbopol 940 Phase 2
41 Hormone Antagonists Phase 2
42 Hormones Phase 2
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
44 Mineral Oil Phase 2
45 Progestins Phase 2
46 Psyllium Nutraceutical Phase 2

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4
2 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3
3 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3
4 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Not yet recruiting NCT03110341 Phase 3
5 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3
6 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2
7 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed NCT00167544 Phase 2
8 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2
9 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2
10 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2
11 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2
12 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
13 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990
14 In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants Completed NCT01203501
15 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
16 Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants Completed NCT00369005
17 Prediction of Brain Injury in Premature Infants Recruiting NCT02814383

Search NIH Clinical Center for Encephalomalacia

Cochrane evidence based reviews: encephalomalacia

Genetic Tests for Encephalomalacia

Anatomical Context for Encephalomalacia

MalaCards organs/tissues related to Encephalomalacia:

39
Brain, Cerebellum, Liver, Occipital Lobe, Kidney, Pons

Publications for Encephalomalacia

Articles related to Encephalomalacia:

(show top 50) (show all 159)
id Title Authors Year
1
MEG may reveal hidden population of spikes in epilepsy with porencephalic cyst/encephalomalacia. ( 27870647 )
2016
2
Bilateral Cortical Encephalomalacia in a Patient Implanted With Bilateral Deep Brain Stimulation for Alzheimer's Disease: Case Report. ( 25850733 )
2015
3
Parieto-occipital encephalomalacia in children; clinical and electrophysiological features of twenty-seven cases. ( 26167209 )
2015
4
Partial optic atrophy and homonymous quadrantanopia in a patient with occipital encephalomalacia. ( 25810973 )
2015
5
Bilateral cystic encephalomalacia following multiple intrauterine transfusions for anti-Kell isoimmunisation. ( 25827913 )
2015
6
Right frontal lobe encephalomalacia in an adult propionic acidemia patient with neuropsychiatric manifestations. ( 27896115 )
2014
7
Prenatal diagnosis of fetal encephalomalacia after maternal diabetic ketoacidosis. ( 25452892 )
2014
8
Magnetoencephalography helps delineate the extent of the epileptogenic zone for surgical planning in children with intractable epilepsy due to porencephalic cyst/encephalomalacia. ( 25014323 )
2014
9
Angioglioma misdiagnosed as encephalomalacia on magnetic resonance imaging for over a decade. ( 24651748 )
2014
10
Normal neurodevelopmental outcome despite severe and early extensive encephalomalacia: plasticity, repair or magic? ( 23789815 )
2013
11
Encephalomalacia in surviving twin after single fetal death diagnosed at 18 weeks of gestation in monochorionic twin pregnancy. ( 24009813 )
2013
12
Severe enteroviral encephalitis complicated by encephalomalacia--case presentation. ( 23272531 )
2012
13
Nigropallidal encephalomalacia in horses grazing Rhaponticum repens (creeping knapweed). ( 22443332 )
2012
14
Focal symmetrical encephalomalacia in young calves. ( 22904025 )
2012
15
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia. ( 21527781 )
2012
16
Multicystic encephalomalacia as an end-stage finding in abusive head trauma. ( 21519862 )
2011
17
Encephalomalacia in the frontal lobe: complication of the endoscopic sinus surgery. ( 22134284 )
2011
18
Hippocampal sclerosis and encephalomalacia as prognostic factors of tuberculous meningitis-related and herpes simplex encephalitis-related epilepsy. ( 21620739 )
2011
19
Focal symmetrical encephalomalacia in a goat. ( 20807946 )
2010
20
Acute retinal necrosis and cystic encephalomalacia in a premature neonate. ( 25390403 )
2010
21
Parieto-occipital encephalomalacia in neonatal hyperammonemia with ornithine transcarbamylase deficiency: A case report. ( 19640662 )
2010
22
Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia. ( 19793632 )
2010
23
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C-->T mutation. ( 18539994 )
2008
24
Multicystic encephalomalacia in an uncomplicated twin pregnancy. ( 18400596 )
2008
25
Prenatal multicystic encephalomalacia due to anomaly of the aortic arch. ( 17628227 )
2007
26
Encephalomalacia with Enterococcus durans infection in the brain stem and cerebral hemisphere in chicks in Japan. ( 16617999 )
2006
27
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. ( 16264405 )
2005
28
HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia. ( 16112158 )
2005
29
Focal symmetrical encephalomalacia in swine from ingestion of Aeschynomene indica seeds. ( 15587245 )
2004
30
Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins. ( 14981409 )
2004
31
Multicystic encephalomalacia. ( 12841409 )
2003
32
Case 46: encephalomalacia in surviving twin after death of monochorionic co-twin. ( 11997543 )
2002
33
Magnetic resonance imaging features of equine nigropallidal encephalomalacia. ( 11499702 )
2001
34
Brain, liver and plasma unsaturated aldehydes in nutritional encephalomalacia of chicks. ( 10842464 )
2000
35
Cerebellar encephalomalacia on magnetic resonance imaging after removal of acoustic tumor. ( 10388897 )
1999
36
Focal symmetrical encephalomalacia in a 6-month-old Dorset sheep. ( 9759513 )
1998
37
Excellent surgical results obtained in patients with a depressed frontal fracture leading to frontal encephalomalacia and intractable frontal seizures. ( 9578021 )
1998
38
Enterococcus-associated encephalomalacia in one-week-old chicks. ( 9823609 )
1998
39
Encephalomalacia associated with vitamin E deficiency in commercially raised emus. ( 9777163 )
1998
40
Bilateral encephalomalacia in a pig related to latent Aujeszky's disease virus infection. ( 9467307 )
1997
41
Neonatal multifocal encephalomalacia and other lesions in the brains of Georgia chicks: 1991-95. ( 8980822 )
1996
42
Multicystic encephalomalacia in term infants. ( 9118144 )
1996
43
The influence of dietary fatty acids and vitamin E on plasma prostanoids and liver microsomal alkane production in broiler chickens with regard to nutritional encephalomalacia. ( 8750206 )
1995
44
Oedipism in a patient with frontal lobe encephalomalacia. ( 8081352 )
1994
45
What is your neurologic diagnosis? Encephalomalacia with possible focal ischemia in a dog. ( 8175464 )
1994
46
Nutritional encephalomalacia in turkeys: diagnosis and growth performance. ( 7832724 )
1994
47
Lipoxygenase and other enzymes of arachidonic acid metabolism in the brain of chicks affected by nutritional encephalomalacia. ( 8462729 )
1993
48
Encephalomalacia in first-week chicks. ( 8488665 )
1993
49
Immunohistological study of encephalomalacia in pigs infected with Aujeszky's disease virus. ( 8396159 )
1993
50
Hydranencephaly/multicystic encephalomalacia: association with congenital rubella infection. ( 8375892 )
1993

Variations for Encephalomalacia

Expression for Encephalomalacia

Search GEO for disease gene expression data for Encephalomalacia.

Pathways for Encephalomalacia

GO Terms for Encephalomalacia

Sources for Encephalomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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