MCID: ENC005
MIFTS: 36

Encephalomalacia

Categories: Neuronal diseases

Aliases & Classifications for Encephalomalacia

MalaCards integrated aliases for Encephalomalacia:

Name: Encephalomalacia 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2034
MeSH 41 D004678
NCIt 46 C98920
SNOMED-CT 64 58762006
UMLS 69 C0014068

Summaries for Encephalomalacia

MalaCards based summary : Encephalomalacia is related to porencephaly and encephalomalacia, multilocular. An important gene associated with Encephalomalacia is SUOX (Sulfite Oxidase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Antifolate resistance. The drugs Magnesium Sulfate and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and liver, and related phenotype is mortality/aging.

Related Diseases for Encephalomalacia

Diseases related to Encephalomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 porencephaly 32.0 MTHFR SIX3
2 encephalomalacia, multilocular 11.9
3 osteoporotic fracture 10.3 IL6 MTHFR
4 sudden sensorineural hearing loss 10.3 IL6 MTHFR
5 gastroschisis 10.2 IL6 MTHFR
6 cervical incompetence 10.2 IL6 SERPINH1
7 funisitis 10.2 IL6 SERPINH1
8 ischemic heart disease 10.2 IL6 MTHFR
9 vaginal disease 10.2 IL6 SERPINH1
10 central retinal vein occlusion 10.2 IL6 MTHFR
11 vaginitis 10.2 IL6 SERPINH1
12 transient arthritis 10.2 IL6 MBP
13 molybdenum cofactor deficiency 10.2 MOCS1 MOCS3 SUOX
14 preterm premature rupture of the membranes 10.2 IL6 SERPINH1
15 endometrial disease 10.2 IL6 SERPINH1
16 hematopoietic stem cell transplantation 10.2 IL6 MTHFR
17 transverse myelitis 10.2 IL6 MBP
18 myelitis 10.1 IL6 MBP
19 traumatic brain injury 10.1 IL6 MBP
20 cerebritis 10.1
21 viral encephalitis 10.1 IL6 MBP
22 perinatal necrotizing enterocolitis 10.1 IL6 SERPINH1
23 holocarboxylase synthetase deficiency 10.1 MTHFR PC
24 spinal cord disease 10.0 AVPR2 MBP SERPINH1
25 uterine anomalies 10.0 IL6 MTHFR SERPINH1
26 placenta disease 10.0 IL6 MTHFR SERPINH1
27 meningoencephalitis 10.0 IL6 MBP
28 neuromyelitis optica 9.9 IL6 MBP
29 epilepsy 9.9
30 encephalitis 9.9
31 schizencephaly 9.9 MTHFR SIX3
32 brain injury 9.9 IL6 MBP
33 blood group, i system 9.8
34 hydranencephaly 9.8
35 pancreatitis 9.8
36 herpes simplex 9.8
37 meningitis 9.8
38 muscular dystrophy 9.8
39 retinal vein occlusion 9.8 IL6 MTHFR
40 leukomalacia 9.8 IL6 MBP MYT1
41 alzheimer disease 9.7
42 schizophrenia 9.7
43 aging 9.7
44 propionic acidemia 9.7
45 myocardial infarction 9.7
46 diabetes mellitus, ketosis-prone 9.7
47 bacteremia 2 9.7
48 hyperprolactinemia 9.7
49 carbonic anhydrase va deficiency, hyperammonemia due to 9.7
50 cerebral hemorrhage 9.7

Graphical network of the top 20 diseases related to Encephalomalacia:



Diseases related to Encephalomalacia

Symptoms & Phenotypes for Encephalomalacia

MGI Mouse Phenotypes related to Encephalomalacia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 AVPR2 CPVL IL6 MBP MTHFR MYT1

Drugs & Therapeutics for Encephalomalacia

Drugs for Encephalomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
2 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
3 Anesthetics Phase 4,Phase 3
4 Anti-Arrhythmia Agents Phase 4,Phase 3
5 Anticonvulsants Phase 4,Phase 3
6 calcium channel blockers Phase 4,Phase 3
7 Calcium, Dietary Phase 4,Phase 3
8 Central Nervous System Depressants Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
11
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
12 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
13 Hematinics Phase 3,Phase 1,Phase 2
14 Anti-Asthmatic Agents Phase 2, Phase 3
15 Antioxidants Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 Bronchodilator Agents Phase 2, Phase 3
18 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
19 Neurotransmitter Agents Phase 2, Phase 3
20 Protective Agents Phase 2, Phase 3
21 Respiratory System Agents Phase 2, Phase 3
22 Vasodilator Agents Phase 2, Phase 3
23 Acidophilus Nutraceutical Phase 3
24
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
25
Ampicillin Approved, Vet_approved Phase 2 69-53-4 6249
26
Cefotaxime Approved Phase 2 63527-52-6 5742673 456256
27
Cefoxitin Approved Phase 2 35607-66-0 441199
28
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
29
Mineral oil Approved, Vet_approved Phase 2 8042-47-5
30
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
31
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
32 Pharmaceutical Solutions Phase 1, Phase 2
33 Anti-Inflammatory Agents Phase 2,Phase 1
34 Cortisol succinate Phase 2
35 Hydrocortisone 17-butyrate 21-propionate Phase 2
36 Hydrocortisone acetate Phase 2
37 Hydrocortisone-17-butyrate Phase 2
38 Anti-Bacterial Agents Phase 2
39 Antibiotics, Antitubercular Phase 2
40 Anti-Infective Agents Phase 2
41 Antitubercular Agents Phase 2
42 Gentamicins Phase 2
43 Analgesics, Non-Narcotic Phase 1, Phase 2
44 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
45 Antirheumatic Agents Phase 1, Phase 2
46 Cyclooxygenase Inhibitors Phase 1, Phase 2
47 Calcium polycarbophil Phase 2
48 Carbopol 940 Phase 2
49 Hormone Antagonists Phase 2
50 Hormones Phase 2

Interventional clinical trials:

(show all 18)

# Name Status NCT ID Phase Drugs
1 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
2 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
3 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
4 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
5 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
6 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
7 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed NCT00167544 Phase 2 Hydrocortisone;Placebo
8 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline
9 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
10 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2 Indomethacin;placebo infusion
11 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
12 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
13 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
14 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990
15 In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants Completed NCT01203501
16 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
17 Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants Completed NCT00369005
18 Prediction of Brain Injury in Premature Infants Recruiting NCT02814383

Search NIH Clinical Center for Encephalomalacia

Cochrane evidence based reviews: encephalomalacia

Genetic Tests for Encephalomalacia

Anatomical Context for Encephalomalacia

MalaCards organs/tissues related to Encephalomalacia:

38
Brain, Cerebellum, Liver, Occipital Lobe, Pons, Kidney

Publications for Encephalomalacia

Articles related to Encephalomalacia:

(show top 50) (show all 163)
# Title Authors Year
1
Glioblastoma arising within sites of encephalomalacia from cerebrovascular insult: two cases and a review of the literature. ( 29422364 )
2018
2
Multicystic encephalomalacia secondary to head trauma. ( 28149115 )
2017
3
The Use of Ultrabrief Left Unilateral Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and Right-Sided Encephalomalacia and Stroke: A Case Report. ( 28767530 )
2017
4
Abnormal parietal encephalomalacia associated with schizophrenia: A case report. ( 28272261 )
2017
5
MEG may reveal hidden population of spikes in epilepsy with porencephalic cyst/encephalomalacia. ( 27870647 )
2016
6
Bilateral cystic encephalomalacia following multiple intrauterine transfusions for anti-Kell isoimmunisation. ( 25827913 )
2015
7
Parieto-occipital encephalomalacia in children; clinical and electrophysiological features of twenty-seven cases. ( 26167209 )
2015
8
Bilateral Cortical Encephalomalacia in a Patient Implanted With Bilateral Deep Brain Stimulation for Alzheimer's Disease: Case Report. ( 25850733 )
2015
9
Partial optic atrophy and homonymous quadrantanopia in a patient with occipital encephalomalacia. ( 25810973 )
2015
10
Right frontal lobe encephalomalacia in an adult propionic acidemia patient with neuropsychiatric manifestations. ( 27896115 )
2014
11
Prenatal diagnosis of fetal encephalomalacia after maternal diabetic ketoacidosis. ( 25452892 )
2014
12
Magnetoencephalography helps delineate the extent of the epileptogenic zone for surgical planning in children with intractable epilepsy due to porencephalic cyst/encephalomalacia. ( 25014323 )
2014
13
Angioglioma misdiagnosed as encephalomalacia on magnetic resonance imaging for over a decade. ( 24651748 )
2014
14
Encephalomalacia in surviving twin after single fetal death diagnosed at 18 weeks of gestation in monochorionic twin pregnancy. ( 24009813 )
2013
15
Normal neurodevelopmental outcome despite severe and early extensive encephalomalacia: plasticity, repair or magic? ( 23789815 )
2013
16
Focal symmetrical encephalomalacia in young calves. ( 22904025 )
2012
17
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia. ( 21527781 )
2012
18
Nigropallidal encephalomalacia in horses grazing Rhaponticum repens (creeping knapweed). ( 22443332 )
2012
19
Severe enteroviral encephalitis complicated by encephalomalacia--case presentation. ( 23272531 )
2012
20
Hippocampal sclerosis and encephalomalacia as prognostic factors of tuberculous meningitis-related and herpes simplex encephalitis-related epilepsy. ( 21620739 )
2011
21
Encephalomalacia in the frontal lobe: complication of the endoscopic sinus surgery. ( 22134284 )
2011
22
Multicystic encephalomalacia as an end-stage finding in abusive head trauma. ( 21519862 )
2011
23
Parieto-occipital encephalomalacia in neonatal hyperammonemia with ornithine transcarbamylase deficiency: A case report. ( 19640662 )
2010
24
Acute retinal necrosis and cystic encephalomalacia in a premature neonate. ( 25390403 )
2010
25
Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia. ( 19793632 )
2010
26
Focal symmetrical encephalomalacia in a goat. ( 20807946 )
2010
27
Multicystic encephalomalacia in an uncomplicated twin pregnancy. ( 18400596 )
2008
28
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C-->T mutation. ( 18539994 )
2008
29
Prenatal multicystic encephalomalacia due to anomaly of the aortic arch. ( 17628227 )
2007
30
Encephalomalacia with Enterococcus durans infection in the brain stem and cerebral hemisphere in chicks in Japan. ( 16617999 )
2006
31
HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia. ( 16112158 )
2005
32
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. ( 16264405 )
2005
33
Focal symmetrical encephalomalacia in swine from ingestion of Aeschynomene indica seeds. ( 15587245 )
2004
34
Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins. ( 14981409 )
2004
35
Multicystic encephalomalacia. ( 12841409 )
2003
36
Case 46: encephalomalacia in surviving twin after death of monochorionic co-twin. ( 11997543 )
2002
37
Magnetic resonance imaging features of equine nigropallidal encephalomalacia. ( 11499702 )
2001
38
Brain, liver and plasma unsaturated aldehydes in nutritional encephalomalacia of chicks. ( 10842464 )
2000
39
Cerebellar encephalomalacia on magnetic resonance imaging after removal of acoustic tumor. ( 10388897 )
1999
40
Enterococcus-associated encephalomalacia in one-week-old chicks. ( 9823609 )
1998
41
Focal symmetrical encephalomalacia in a 6-month-old Dorset sheep. ( 9759513 )
1998
42
Excellent surgical results obtained in patients with a depressed frontal fracture leading to frontal encephalomalacia and intractable frontal seizures. ( 9578021 )
1998
43
Encephalomalacia associated with vitamin E deficiency in commercially raised emus. ( 9777163 )
1998
44
Bilateral encephalomalacia in a pig related to latent Aujeszky's disease virus infection. ( 9467307 )
1997
45
Neonatal multifocal encephalomalacia and other lesions in the brains of Georgia chicks: 1991-95. ( 8980822 )
1996
46
Multicystic encephalomalacia in term infants. ( 9118144 )
1996
47
The influence of dietary fatty acids and vitamin E on plasma prostanoids and liver microsomal alkane production in broiler chickens with regard to nutritional encephalomalacia. ( 8750206 )
1995
48
Oedipism in a patient with frontal lobe encephalomalacia. ( 8081352 )
1994
49
Nutritional encephalomalacia in turkeys: diagnosis and growth performance. ( 7832724 )
1994
50
What is your neurologic diagnosis? Encephalomalacia with possible focal ischemia in a dog. ( 8175464 )
1994

Variations for Encephalomalacia

Expression for Encephalomalacia

Search GEO for disease gene expression data for Encephalomalacia.

Pathways for Encephalomalacia

GO Terms for Encephalomalacia

Biological processes related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 telencephalon development GO:0021537 9.16 AVPR2 SIX3
2 molybdopterin cofactor biosynthetic process GO:0032324 8.96 MOCS1 MOCS3
3 Mo-molybdopterin cofactor biosynthetic process GO:0006777 8.62 MOCS1 MOCS3

Molecular functions related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 8.92 MOCS1 MOCS3 MTHFR PC

Sources for Encephalomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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