MCID: ENC005
MIFTS: 27

Encephalomalacia

Categories: Neuronal diseases

Aliases & Classifications for Encephalomalacia

MalaCards integrated aliases for Encephalomalacia:

Name: Encephalomalacia 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2034
MeSH 42 D004678
NCIt 47 C98920
SNOMED-CT 64 58762006
UMLS 69 C0014068

Summaries for Encephalomalacia

MalaCards based summary : Encephalomalacia is related to porencephaly and cerebritis. An important gene associated with Encephalomalacia is SUOX (Sulfite Oxidase). The drugs Magnesium Sulfate and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and liver.

Related Diseases for Encephalomalacia

Diseases related to Encephalomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 porencephaly 11.2
2 cerebritis 10.0
3 encephalitis 9.8
4 epilepsy 9.8
5 herpes simplex 9.7
6 meningitis 9.7
7 muscular dystrophy 9.7
8 hydranencephaly 9.7
9 pancreatitis 9.7
10 hepatitis 9.6
11 infertility 9.6
12 seizure disorder 9.6
13 lennox-gastaut syndrome 9.6
14 cerebral lymphoma 9.6
15 lymphoma 9.6
16 neuronitis 9.6
17 partial optic atrophy 9.6
18 vasculitis 9.6
19 disseminated intravascular coagulation 9.6
20 rubella 9.6
21 hepatic coma 9.6
22 cerebral atherosclerosis 9.6
23 schizophrenia 9.6
24 arteriosclerosis 9.6
25 congenital rubella 9.6
26 myocardial infarction 9.6
27 acute pancreatitis 9.6
28 herpes simplex encephalitis 9.6
29 bacteremia 9.6
30 ischemia 9.6
31 tuberculous meningitis 9.6
32 hyperprolactinemia 9.6
33 hyperammonemia 9.6
34 ornithine transcarbamylase deficiency 9.6
35 retinitis 9.6
36 aneurysm 9.6
37 atherosclerosis 9.6
38 anoxia 9.6
39 cerebral hemorrhage 9.6
40 cerebral aneurysms 9.6

Graphical network of the top 20 diseases related to Encephalomalacia:



Diseases related to Encephalomalacia

Symptoms & Phenotypes for Encephalomalacia

Drugs & Therapeutics for Encephalomalacia

Drugs for Encephalomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3 7487-88-9 24083
2 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
3 calcium channel blockers Phase 4,Phase 3
4 Central Nervous System Depressants Phase 4,Phase 3
5 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
6 Anesthetics Phase 4,Phase 3
7 Anti-Arrhythmia Agents Phase 4,Phase 3
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anticonvulsants Phase 4,Phase 3
10 Calcium, Dietary Phase 4,Phase 3
11
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
12 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
13 Hematinics Phase 3,Phase 1,Phase 2
14 Respiratory System Agents Phase 2, Phase 3
15 Neurotransmitter Agents Phase 2, Phase 3
16 Vasodilator Agents Phase 2, Phase 3
17 Anti-Asthmatic Agents Phase 2, Phase 3
18 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
19 Protective Agents Phase 2, Phase 3
20 Autonomic Agents Phase 2, Phase 3
21 Bronchodilator Agents Phase 2, Phase 3
22 Antioxidants Phase 2, Phase 3
23 Acidophilus Nutraceutical Phase 3
24
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
25
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
26
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
27
Glycerol Approved, Investigational Phase 2 56-81-5 753
28
Ampicillin Approved, Vet_approved Phase 2 69-53-4 6249
29
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
30
Cefoxitin Approved Phase 2 35607-66-0 441199
31
Mineral oil Approved, Vet_approved Phase 2 8042-47-5
32
Butyric Acid Experimental Phase 2 107-92-6 264
33 Pharmaceutical Solutions Phase 1, Phase 2
34 Cortisol succinate Phase 2
35 Hydrocortisone 17-butyrate 21-propionate Phase 2
36 Hydrocortisone acetate Phase 2
37 Hydrocortisone-17-butyrate Phase 2
38 Anti-Inflammatory Agents Phase 2,Phase 1
39 Progestins Phase 2
40 Gentamicins Phase 2
41 Cyclooxygenase Inhibitors Phase 1, Phase 2
42 Analgesics, Non-Narcotic Phase 1, Phase 2
43 Hormone Antagonists Phase 2
44 Hormones Phase 2
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
46 Anti-Bacterial Agents Phase 2
47 Anti-Infective Agents Phase 2
48 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
49 Antibiotics, Antitubercular Phase 2
50 Antirheumatic Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
2 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
3 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
4 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
5 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
6 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
7 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed NCT00167544 Phase 2 Hydrocortisone;Placebo
8 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline
9 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
10 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2 Indomethacin;placebo infusion
11 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
12 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
13 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
14 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990
15 In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants Completed NCT01203501
16 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
17 Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants Completed NCT00369005
18 Prediction of Brain Injury in Premature Infants Recruiting NCT02814383

Search NIH Clinical Center for Encephalomalacia

Cochrane evidence based reviews: encephalomalacia

Genetic Tests for Encephalomalacia

Anatomical Context for Encephalomalacia

MalaCards organs/tissues related to Encephalomalacia:

39
Brain, Cerebellum, Liver, Occipital Lobe, Kidney, Pons

Publications for Encephalomalacia

Articles related to Encephalomalacia:

(show top 50) (show all 162)
id Title Authors Year
1
Abnormal parietal encephalomalacia associated with schizophrenia: A case report. ( 28272261 )
2017
2
The Use of Ultrabrief Left Unilateral Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and Right-Sided Encephalomalacia and Stroke: A Case Report. ( 28767530 )
2017
3
Multicystic encephalomalacia secondary to head trauma. ( 28149115 )
2017
4
MEG may reveal hidden population of spikes in epilepsy with porencephalic cyst/encephalomalacia. ( 27870647 )
2016
5
Bilateral cystic encephalomalacia following multiple intrauterine transfusions for anti-Kell isoimmunisation. ( 25827913 )
2015
6
Parieto-occipital encephalomalacia in children; clinical and electrophysiological features of twenty-seven cases. ( 26167209 )
2015
7
Partial optic atrophy and homonymous quadrantanopia in a patient with occipital encephalomalacia. ( 25810973 )
2015
8
Bilateral Cortical Encephalomalacia in a Patient Implanted With Bilateral Deep Brain Stimulation for Alzheimer's Disease: Case Report. ( 25850733 )
2015
9
Right frontal lobe encephalomalacia in an adult propionic acidemia patient with neuropsychiatric manifestations. ( 27896115 )
2014
10
Prenatal diagnosis of fetal encephalomalacia after maternal diabetic ketoacidosis. ( 25452892 )
2014
11
Magnetoencephalography helps delineate the extent of the epileptogenic zone for surgical planning in children with intractable epilepsy due to porencephalic cyst/encephalomalacia. ( 25014323 )
2014
12
Angioglioma misdiagnosed as encephalomalacia on magnetic resonance imaging for over a decade. ( 24651748 )
2014
13
Normal neurodevelopmental outcome despite severe and early extensive encephalomalacia: plasticity, repair or magic? ( 23789815 )
2013
14
Encephalomalacia in surviving twin after single fetal death diagnosed at 18 weeks of gestation in monochorionic twin pregnancy. ( 24009813 )
2013
15
Focal symmetrical encephalomalacia in young calves. ( 22904025 )
2012
16
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia. ( 21527781 )
2012
17
Nigropallidal encephalomalacia in horses grazing Rhaponticum repens (creeping knapweed). ( 22443332 )
2012
18
Severe enteroviral encephalitis complicated by encephalomalacia--case presentation. ( 23272531 )
2012
19
Encephalomalacia in the frontal lobe: complication of the endoscopic sinus surgery. ( 22134284 )
2011
20
Hippocampal sclerosis and encephalomalacia as prognostic factors of tuberculous meningitis-related and herpes simplex encephalitis-related epilepsy. ( 21620739 )
2011
21
Multicystic encephalomalacia as an end-stage finding in abusive head trauma. ( 21519862 )
2011
22
Parieto-occipital encephalomalacia in neonatal hyperammonemia with ornithine transcarbamylase deficiency: A case report. ( 19640662 )
2010
23
Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia. ( 19793632 )
2010
24
Acute retinal necrosis and cystic encephalomalacia in a premature neonate. ( 25390403 )
2010
25
Focal symmetrical encephalomalacia in a goat. ( 20807946 )
2010
26
Multicystic encephalomalacia in an uncomplicated twin pregnancy. ( 18400596 )
2008
27
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C-->T mutation. ( 18539994 )
2008
28
Prenatal multicystic encephalomalacia due to anomaly of the aortic arch. ( 17628227 )
2007
29
Encephalomalacia with Enterococcus durans infection in the brain stem and cerebral hemisphere in chicks in Japan. ( 16617999 )
2006
30
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. ( 16264405 )
2005
31
HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia. ( 16112158 )
2005
32
Focal symmetrical encephalomalacia in swine from ingestion of Aeschynomene indica seeds. ( 15587245 )
2004
33
Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins. ( 14981409 )
2004
34
Multicystic encephalomalacia. ( 12841409 )
2003
35
Case 46: encephalomalacia in surviving twin after death of monochorionic co-twin. ( 11997543 )
2002
36
Magnetic resonance imaging features of equine nigropallidal encephalomalacia. ( 11499702 )
2001
37
Brain, liver and plasma unsaturated aldehydes in nutritional encephalomalacia of chicks. ( 10842464 )
2000
38
Cerebellar encephalomalacia on magnetic resonance imaging after removal of acoustic tumor. ( 10388897 )
1999
39
Encephalomalacia associated with vitamin E deficiency in commercially raised emus. ( 9777163 )
1998
40
Enterococcus-associated encephalomalacia in one-week-old chicks. ( 9823609 )
1998
41
Focal symmetrical encephalomalacia in a 6-month-old Dorset sheep. ( 9759513 )
1998
42
Excellent surgical results obtained in patients with a depressed frontal fracture leading to frontal encephalomalacia and intractable frontal seizures. ( 9578021 )
1998
43
Bilateral encephalomalacia in a pig related to latent Aujeszky's disease virus infection. ( 9467307 )
1997
44
Multicystic encephalomalacia in term infants. ( 9118144 )
1996
45
Neonatal multifocal encephalomalacia and other lesions in the brains of Georgia chicks: 1991-95. ( 8980822 )
1996
46
The influence of dietary fatty acids and vitamin E on plasma prostanoids and liver microsomal alkane production in broiler chickens with regard to nutritional encephalomalacia. ( 8750206 )
1995
47
Nutritional encephalomalacia in turkeys: diagnosis and growth performance. ( 7832724 )
1994
48
Oedipism in a patient with frontal lobe encephalomalacia. ( 8081352 )
1994
49
What is your neurologic diagnosis? Encephalomalacia with possible focal ischemia in a dog. ( 8175464 )
1994
50
Encephalomalacia in first-week chicks. ( 8488665 )
1993

Variations for Encephalomalacia

Expression for Encephalomalacia

Search GEO for disease gene expression data for Encephalomalacia.

Pathways for Encephalomalacia

GO Terms for Encephalomalacia

Sources for Encephalomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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