MCID: ENC006
MIFTS: 48

Encephalomyelitis malady

Summaries for Encephalomyelitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number... more...

MalaCards: Encephalomyelitis, also known as encephalitis &/or myelitis, is related to hepatitis c and arthritis. An important gene associated with Encephalomyelitis is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Matrix Metalloproteinases and GPCR Pathway. The compounds gm 6001 and gi 254023x have been mentioned in the context of this disorder.

Aliases & Classifications for Encephalomyelitis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

encephalomyelitis 8 45 61
encephalitis &/or myelitis 8
encephalitis/myelitis nos 8
encephalomyelitis nos 8


Related Diseases for Encephalomyelitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c30.2MMP7
2arthritis30.1MMP13, MMP17, MMP12, MMP8, MMP10
3sensory peripheral neuropathy29.7ELAVL4, ELAVL3
4allergic encephalomyelitis11.2
5acute disseminated encephalomyelitis11.2
6chronic fatigue syndrome10.7
7western equine encephalitis10.5
8postinfectious encephalomyelitis10.5
9n syndrome10.4
10myoclonus10.4
11immune-mediated encephalomyelitis10.3
12hepatitis e10.3
13measles10.3
14uveitis10.3
15myelitis10.2
16hepatitis d10.2
17hepatitis a10.2
18subacute sclerosing panencephalitis10.2
19neuromyelitis optica10.2
20rabies10.2
21eastern equine encephalitis10.2
22transverse myelitis10.2
23japanese encephalitis10.2
24micro syndrome10.2
25acute transverse myelitis10.2
26vaccinia10.1
27st. louis encephalitis10.1
28orchitis10.1
29viral encephalitis10.1
30gliomatosis cerebri10.1
31stiff-person syndrome10.1
32vasculitis10.1
33acute hemorrhagic leukoencephalitis10.1
34rift valley fever10.1
35aseptic meningitis10.1
36small cell carcinoma10.1
37venezuelan equine encephalitis10.1
38plasmodium vivax malaria10.1
39scrub typhus10.1
40retinal vasculitis10.1
41typhus10.1
42char syndrome10.1
43guillain-barr� syndrome10.1
44hypersomnia10.1
45hepatitis c virus10.1
46adenocarcinoma10.0MMP26, MMP11, MMP7, MMP12, MMP10, MMP13
47lung cancer10.0MMP8, MMP7, MMP10, MMP13, MMP12, ELAVL3
48squamous cell carcinoma10.0MMP12, MMP10, MMP13, MMP7, MMP26, MMP11
49rheumatoid arthritis10.0MMP13, MMP19, MMP8, MMP12, MMP11
50multiple sclerosis10.0MMP19, MMP12, MMP8, MMP7

Graphical network of the top 20 diseases related to Encephalomyelitis:



Diseases related to encephalomyelitis

Clinical Features for Encephalomyelitis

Drugs & Therapeutics for Encephalomyelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Encephalomyelitis

Search NIH Clinical Center for Encephalomyelitis

Search CenterWatch for Encephalomyelitis

Genetic Tests for Encephalomyelitis

Anatomical Context for Encephalomyelitis

Animal Models for Encephalomyelitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Encephalomyelitis

Sources:
51PubMed
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Articles related to Encephalomyelitis:

(show top 50)    (show all 1889)
idTitleAuthorsYear
1
Previous infection with Staphylococcus aureus strains attenuated experimental encephalomyelitis. (24401094)
2014
2
Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development. (24154625)
2013
3
Anti-glycine receptor antibody mediated progressive encephalomyelitis with rigidity and myoclonus associated with breast cancer. (23936697)
2013
4
Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis. (24252604)
2013
5
Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: a rare fatal complication. (23485346)
2013
6
'The letting go, the building up, [and] the gradual process of rebuilding': identity change and post-traumatic growth in myalgic encephalomyelitis/chronic fatigue syndrome. (22963543)
2013
7
Mice deficient in interferon-gamma or interferon-gamma receptor 1 have distinct inflammatory responses to acute viral encephalomyelitis. (24204622)
2013
8
Complexity of trophic factor signaling in experimental autoimmune encephalomyelitis: differential expression of neurotrophic and gliotrophic factors. (23763772)
2013
9
Extensive acute disseminated encephalomyelitis in a young girl responding to intravenous methylprednisolone. (24092604)
2013
10
The MAO inhibitor phenelzine can improve functional outcomes in mice with established clinical signs in experimental autoimmune encephalomyelitis (EAE). (23777648)
2013
11
Simultaneous development of acute disseminated encephalomyelitis and Guillain-BarrAc syndrome associated with H1N1 09 influenza vaccination. (22728497)
2012
12
Multiphasic acute disseminated encephalomyelitis (ADEM) following influenza type A (swine specific H1N1). (21997495)
2012
13
Treg cell resistance to apoptosis in DNA vaccination for experimental autoimmune encephalomyelitis treatment. (23166807)
2012
14
Impact of acupuncture by using life-energy (qi) oriental needle on the paralysis of rats with experimental autoimmune encephalomyelitis. (22809030)
2012
15
Immunoenrichment microwave and magnetic proteomics for quantifying CD47 in the experimental autoimmune encephalomyelitis model of multiple sclerosis. (23160929)
2012
16
The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis. (22788993)
2012
17
A preliminary prospective study of nutritional, psychological and combined therapies for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in a private care setting. (23166120)
2012
18
Bithalamic compromise in acute disseminated encephalomyelitis following H1N1 influenza vaccine. (21755147)
2011
19
Acute disseminated encephalomyelitis associated with optic neuritis and marked peri-papillary hemorrhages. (21941362)
2011
20
Relapsing acute disseminated encephalomyelitis in children: further evaluation of the diagnosis. (20823029)
2010
21
T cells facilitate recovery from Venezuelan equine encephalitis virus-induced encephalomyelitis in the absence of antibody. (20181704)
2010
22
Long-term expression of tissue-inhibitor of matrix metalloproteinase-1 in the murine central nervous system does not alter the morphological and behavioral phenotype but alleviates the course of experimental allergic encephalomyelitis. (20558576)
2010
23
Experimental study of implantation of neurotropin-3 modified olfactory ensheathing cells in experimental allergic encephalomyelitis]. (20017332)
2009
24
p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation. (19458044)
2009
25
Acute disseminated encephalomyelitis presenting as acute psychotic disorder. (19129570)
2008
26
Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. (18997868)
2008
27
von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis. (18688020)
2008
28
Scrub typhus-associated acute disseminated encephalomyelitis. (17214088)
2006
29
Central brain herniation secondary to fulminant acute disseminated encephalomyelitis: implications for neurosurgical management. Case report. (16961146)
2006
30
Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis. (16628262)
2006
31
Catatonic syndrome related to acute disseminated encephalomyelitis (ADEM). (16733085)
2006
32
Evaluating association and transmission of eight inflammatory genes with Viliuisk encephalomyelitis susceptibility. (15182325)
2004
33
Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2 alpha in the central nervous system of SJL mice with experimental allergic encephalomyelitis. (15160394)
2004
34
Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. (12745627)
2003
35
Acute disseminated encephalomyelitis in children: outcome and prognosis. (12973660)
2003
36
Bilateral anterior optic neuritis in adult measles infection without encephalomyelitis. (12429258)
2002
37
Mycophenolate mofetil treatment accelerates recovery from experimental allergic encephalomyelitis. (11562063)
2001
38
Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. (11376180)
2001
39
Elevated cerebrospinal fluid level of ciliary neurotrophic factor in acute disseminated encephalomyelitis. (10980311)
2000
40
Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat. (10537116)
1999
41
Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis. (10319881)
1999
42
Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. (9203563)
1997
43
Depletion of T lymphocytes with immunotoxin retards the progress of experimental allergic encephalomyelitis in rhesus monkeys. (9140093)
1997
44
Seasonal variation in the vector competence of Culex tarsalis (Diptera:Culicidae) from the Coachella Valley of California for western equine encephalomyelitis and St. Louis encephalitis viruses. (8667391)
1996
45
Allergic Encephalomyelitis in Common Marmosets: Pathogenesis of a Multiple Sclerosis-like Lesion (8954853)
1996
46
The proximal peripheral nervous system is a major site of demyelination in experimental autoimmune encephalomyelitis induced in the Lewis rat by a myelin basic protein-specific T cell clone. (7545859)
1995
47
Interleukin-10 prevents experimental allergic encephalomyelitis in rats. (7515815)
1994
48
Rift Valley fever virus-induced encephalomyelitis and hepatitis in calves. (1448895)
1992
49
Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys; disseminated encephalomyelitis produced in monkeys with their own brain tissue. (18113912)
1949
50
Experimental studies on acute disseminated encephalomyelitis in the rhesus monkey. (18856255)
1948

Genetic Variations for Encephalomyelitis

Expression for genes affiliated with Encephalomyelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalomyelitis

Search GEO for disease gene expression data for Encephalomyelitis.

Pathways for genes affiliated with Encephalomyelitis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 12EMD Millipore
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Compounds for genes affiliated with Encephalomyelitis

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR
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Compounds related to Encephalomyelitis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1gm 60016012.2MMP20, MMP12, MMP8, MMP10, MMP23B, MMP23A
2gi 254023x6012.2MMP11, MMP7, MMP27, MMP25, MMP28, MMP19
3uk 3833676012.2MMP19, MMP20, MMP12, MMP8, MMP10, MMP23B
4batimastat45 60 1114.2MMP26, MMP10, MMP23B, MMP23A, MMP13, MMP24
5marimastat45 60 1114.2MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
6calcium45 50 11 2415.0MMP20, MMP12, MMP8, MMP10, MMP13, MMP24
7matrigel4511.1MMP13, MMP10, MMP12, MMP19, MMP7
8oligonucleotide4511.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
9vegf4511.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
10fibrinogen4511.1MMP13, MMP8, MMP12, MMP7, MMP26
11(4-aminophenyl)mercuric acetate4511.1MMP13, MMP10, MMP8, MMP7
12zinc45 2412.1MMP13, MMP8, MMP12, MMP7, MMP11, MMP26
13n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid45 1112.0MMP20, MMP12, MMP10
14hydroxamate4511.0MMP12, MMP8, MMP13
15progesterone45 60 29 11 2414.9MMP15, MMP8, MMP7, MMP11, MMP26
16barbiturate4510.8MMP8, MMP13
17serine4510.8MMP12, MMP8, MMP10, MMP13
18clodronate45 50 1112.6MMP8, MMP13
19p0024510.6MMP13, MMP8, MMP7
20hocl4510.3MMP7, MMP8

GO Terms for genes affiliated with Encephalomyelitis

Sources:
16Gene Ontology
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Cellular components related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557811.6MMP26, MMP24, MMP13, MMP23B, MMP10, MMP8
2extracellular regionGO:00557610.9MMP13, MMP10, MMP8, MMP12, MMP20, MMP19
3extracellular matrixGO:03101210.7MMP21, MMP11, MMP15

Biological processes related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteolysisGO:00650811.7MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
2collagen catabolic processGO:03057411.4MMP27, MMP19, MMP20, MMP12, MMP8, MMP10
3extracellular matrix disassemblyGO:02261711.3MMP15, MMP11, MMP7, MMP19, MMP20, MMP12
4extracellular matrix organizationGO:03019810.9MMP15, MMP13, MMP10, MMP8, MMP12, MMP20
5positive regulation of catalytic activityGO:04308510.7MMP17, MMP24, MMP15

Molecular functions related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00827011.8MMP15, MMP24, MMP13, MMP23B, MMP10, MMP8
2metalloendopeptidase activityGO:00422211.7MMP20, MMP19, MMP28, MMP25, MMP27, MMP7
3calcium ion bindingGO:00550911.7MMP15, MMP21, MMP17, MMP11, MMP24, MMP13
4AU-rich element bindingGO:01709110.6ELAVL4, ELAVL3
5enzyme activator activityGO:00804710.4MMP15, MMP24, MMP17

Products for genes affiliated with Encephalomyelitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Encephalomyelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet