MCID: ENC006
MIFTS: 55

Encephalomyelitis malady

Summaries for Encephalomyelitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number... more...

MalaCards: Encephalomyelitis, also known as encephalitis &/or myelitis, is related to multiple sclerosis and lung cancer. An important gene associated with Encephalomyelitis is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Matrix Metalloproteinases and GPCR Pathway. The compounds gm 6001 and gi 254023x have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Aliases & Classifications for Encephalomyelitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

encephalomyelitis 8 44 60
encephalitis &/or myelitis 8
encephalitis/myelitis nos 8
encephalomyelitis nos 8


Related Diseases for Encephalomyelitis

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17GeneCards, 18GeneDecks
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Diseases related to Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis31.2MMP19, MMP12, MMP8, MMP7
2lung cancer30.2MMP8, MMP7, MMP10, MMP13, MMP12, ELAVL3
3arthritis30.0MMP13, MMP17, MMP12, MMP8, MMP10
4hepatitis c29.9MMP7
5glioblastoma multiforme29.9MMP12, MMP7, MMP15
6rheumatoid arthritis29.7MMP13, MMP19, MMP8, MMP12, MMP11
7breast cancer29.7MMP11, MMP13, MMP7, MMP26, MMP17
8chondrosarcoma29.7MMP13, MMP7
9sensory peripheral neuropathy29.7ELAVL4, ELAVL3
10acute disseminated encephalomyelitis11.1
11chronic fatigue syndrome10.7
12encephalitis10.6
13western equine encephalitis10.5
14st. louis encephalitis10.5
15influenza10.4
16neuronitis10.4
17neuritis10.3
18pneumonia10.3
19louping ill10.3
20central nervous system disease10.3
21meningitis10.3
22nervous system disease10.3
23optic neuritis10.3
24malaria10.3
25measles10.2
26hepatitis10.2
27uveitis10.2
28myelitis10.2
29herpes simplex10.2
30postinfectious encephalomyelitis10.2
31subacute sclerosing panencephalitis10.2
32neuromyelitis optica10.2
33rabies10.2
34eastern equine encephalitis10.2
35immune-mediated encephalomyelitis10.2
36cerebritis10.1
37japanese encephalitis10.1
38hepatitis a10.1
39neuropathy10.1
40plasmodium malariae malaria10.1
41orchitis10.1
42viral encephalitis10.1
43stiff-person syndrome10.1
44leukemia10.1
45pertussis10.1
46poliomyelitis10.1
47retinitis10.1
48vasculitis10.1
49allergic encephalomyelitis10.1
50acute hemorrhagic leukoencephalitis10.0

Graphical network of the top 20 diseases related to Encephalomyelitis:



Diseases related to encephalomyelitis

Clinical Features for Encephalomyelitis

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Drugs & Therapeutics for Encephalomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Encephalomyelitis

Search NIH Clinical Center for Encephalomyelitis

Search CenterWatch for Encephalomyelitis

Genetic Tests for Encephalomyelitis

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Anatomical Context for Encephalomyelitis

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32MalaCards
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MalaCards organs/tissues related to Encephalomyelitis:

32
T cells, Brain, Spinal cord, B cells, Bone, Bone marrow, Lung, Monocytes, Endothelial, Pituitary, Retina, Cortex, Testes, Myeloid, Breast, Thyroid, Skeletal muscle, Eye, Pineal, Nk cells, Prostate, Heart, Skin, Liver, Kidney, Lymph node, Spleen, Whole blood, Thymus, Cerebellum, Thalamus

Animal Models for Encephalomyelitis or affiliated genes

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Publications for Encephalomyelitis

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50PubMed
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Articles related to Encephalomyelitis:

(show top 50)    (show all 1888)
idTitleAuthorsYear
1
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. (22718491)
2013
2
Protein kinase C gamma (PKCI^) as a novel marker to assess the functional status of the corticospinal tract in experimental autoimmune encephalomyelitis (EAE). (23385082)
2013
3
1,25-Dihydroxyvitamin D3 suppresses TLR8 expression and TLR8-mediated inflammatory responses in monocytes in vitro and experimental autoimmune encephalomyelitis in vivo. (23516559)
2013
4
The magnetic resonance imaging appearance of monophasic acute disseminated encephalomyelitis: an update post application of the 2007 consensus criteria. (23608688)
2013
5
A metagenomic approach to investigate the microbial causes of myalgic encephalomyelitis/chronic fatigue syndrome: moving beyond XMRV. (24273702)
2013
6
Independent and interdependent immunoregulatory effects of IL-27, IFN-I^, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis. (23455508)
2013
7
Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells isolated from experimental autoimmune encephalomyelitis mice. (23532769)
2013
8
Glycine receptor antibody mediated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM): a rare but treatable neurological syndrome. (23564494)
2013
9
The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. (22733814)
2012
10
Life-saving decompressive craniectomy for acute disseminated encephalomyelitis in a child: a case report. (22399246)
2012
11
18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions. (22738927)
2012
12
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. (22796435)
2012
13
Active induction of experimental autoimmune encephalomyelitis by MOG35-55 peptide immunization is associated with differential responses in separate compartments of the choroid plexus. (22870943)
2012
14
Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice. (23077723)
2012
15
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis. (21131060)
2011
16
Acute disseminated encephalomyelitis as the first presentation of CNS tuberculosis: report of a case with brief review. (21139988)
2010
17
Childhood multiple sclerosis mimicking acute disseminated encephalomyelitis. (19904508)
2009
18
PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis. (18645614)
2008
19
Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains. (19094215)
2008
20
Acute disseminated encephalomyelitis after liver transplantation. (15824267)
2005
21
Quantifying immunohistochemical staining of phospho-eIF2alpha, heme oxygenase-2 and NADPH cytochrome P450 reductase in oligodendrocytes during experimental autoimmune encephalomyelitis. (15910982)
2005
22
Acute disseminated encephalomyelitis presenting as conversion disorder. (15939989)
2005
23
The head MRI by fluid attenuated inversion recovery (FLAIR) was useful for diagnosis in the patient with post influenza vaccinal acute disseminated encephalomyelitis (ADEM)]. (15461029)
2004
24
Post-infectious encephalomyelitis associated with St. Louis encephalitis virus infection. (15534266)
2004
25
CD8alpha dendritic cells and immune protection from experimental allergic encephalomyelitis. (15320897)
2004
26
Tolerance induction by molecular mimicry: prevention and suppression of experimental autoimmune encephalomyelitis with the milk protein butyrophilin. (14978022)
2004
27
Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. (15161628)
2004
28
Transfer of severe experimental autoimmune encephalomyelitis by IL-12- and IL-18-potentiated T cells is estrogen sensitive. (12707362)
2003
29
Expression of the long form of human FLIP by retroviral gene transfer of hemopoietic stem cells exacerbates experimental autoimmune encephalomyelitis. (12574377)
2003
30
A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein. (12869140)
2003
31
In situ cytokine immune responses in acute disseminated encephalomyelitis: insights into pathophysiologic mechanisms. (12673567)
2003
32
Acute disseminated encephalomyelitis after para-influenza infection post bone marrow transplantation. (11999589)
2002
33
Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL/J mice. (12776697)
2002
34
Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat. (11424629)
2001
35
Scrub typhus encephalomyelitis with prominent focal neurologic signs. (11115244)
2000
36
The role of the antigen-presenting cell in Fas-mediated direct and bystander killing: potential in vivo function of Fas in experimental allergic encephalomyelitis. (9916681)
1999
37
Contrasting effects of anti-adhesion molecule therapy in experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis. (10408964)
1999
38
NMR studies in demyelinating and non-demyelinating experimental allergic encephalomyelitis. An approach involving a dehydration procedure. (9885325)
1999
39
Abnormalities of cardiac repolarization in multiple sclerosis: relationship with a model of allergic encephalomyelitis in rat. (9626255)
1998
40
Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1alpha and monocyte chemotactic protein-1. (9916884)
1998
41
Discontinuation of treatment with IFN-beta leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-beta and excessive expansion of autoreactive T cells as disease promoting mechanisms. (9600704)
1998
42
Anti-myelin antibodies modulate experimental allergic encephalomyelitis in Biozzi ABH mice. (9191212)
1997
43
Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. (8632054)
1996
44
Two models for multiple sclerosis: experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus. (8642393)
1996
45
Eicosenoids Modify Experimental Allergic Encephalomyelitis. (11854849)
1995
46
Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth factor-beta and interleukin-10. (7489740)
1995
47
Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats. (1918383)
1991
48
Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1. (1716279)
1991
49
Cranial MRI in acute disseminated encephalomyelitis. (3340306)
1988
50
Herpes virus hominis encephalomyelitis and retinal vasculitis in adults. (6261661)
1980

Genetic Variations for Encephalomyelitis

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Expression for genes affiliated with Encephalomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalomyelitis

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Pathways for genes affiliated with Encephalomyelitis

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37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Encephalomyelitis

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Encephalomyelitis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1gm 60015912.2MMP20, MMP12, MMP8, MMP10, MMP23B, MMP23A
2gi 254023x5912.2MMP11, MMP7, MMP27, MMP25, MMP28, MMP19
3uk 3833675912.2MMP19, MMP20, MMP12, MMP8, MMP10, MMP23B
4batimastat44 59 1114.2MMP26, MMP10, MMP23B, MMP23A, MMP13, MMP24
5marimastat44 59 1114.2MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
6calcium44 49 11 2415.0MMP20, MMP12, MMP8, MMP10, MMP13, MMP24
7matrigel4411.1MMP13, MMP10, MMP12, MMP19, MMP7
8oligonucleotide4411.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
9vegf4411.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
10fibrinogen4411.1MMP13, MMP8, MMP12, MMP7, MMP26
11(4-aminophenyl)mercuric acetate4411.1MMP13, MMP10, MMP8, MMP7
12zinc44 2412.1MMP13, MMP8, MMP12, MMP7, MMP11, MMP26
13n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1112.0MMP20, MMP12, MMP10
14hydroxamate4411.0MMP12, MMP8, MMP13
15progesterone44 59 28 11 2414.9MMP15, MMP8, MMP7, MMP11, MMP26
16barbiturate4410.8MMP8, MMP13
17serine4410.8MMP12, MMP8, MMP10, MMP13
18clodronate44 49 1112.6MMP8, MMP13
19p0024410.6MMP13, MMP8, MMP7
20hocl4410.3MMP7, MMP8

GO Terms for genes affiliated with Encephalomyelitis

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16Gene Ontology
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Cellular components related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557811.6MMP26, MMP24, MMP13, MMP23B, MMP10, MMP8
2extracellular regionGO:00557610.9MMP13, MMP10, MMP8, MMP12, MMP20, MMP19
3extracellular matrixGO:03101210.7MMP21, MMP11, MMP15

Biological processes related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteolysisGO:00650811.7MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
2collagen catabolic processGO:03057411.4MMP27, MMP19, MMP20, MMP12, MMP8, MMP10
3extracellular matrix disassemblyGO:02261711.3MMP15, MMP11, MMP7, MMP19, MMP20, MMP12
4extracellular matrix organizationGO:03019810.9MMP15, MMP13, MMP10, MMP8, MMP12, MMP20
5positive regulation of catalytic activityGO:04308510.7MMP17, MMP24, MMP15

Molecular functions related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00827011.8MMP15, MMP24, MMP13, MMP23B, MMP10, MMP8
2metalloendopeptidase activityGO:00422211.7MMP20, MMP19, MMP28, MMP25, MMP27, MMP7
3calcium ion bindingGO:00550911.7MMP15, MMP21, MMP17, MMP11, MMP24, MMP13
4AU-rich element bindingGO:01709110.6ELAVL4, ELAVL3
5enzyme activator activityGO:00804710.4MMP15, MMP24, MMP17

Products for genes affiliated with Encephalomyelitis

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Sources for Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet