MCID: ENC006
MIFTS: 55

Encephalomyelitis malady

Summaries for Encephalomyelitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number... more...

MalaCards: Encephalomyelitis, also known as encephalitis &/or myelitis, is related to multiple sclerosis and lung cancer. An important gene associated with Encephalomyelitis is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Matrix Metalloproteinases and GPCR Pathway. The compounds gm 6001 and gi 254023x have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Aliases & Classifications for Encephalomyelitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

encephalomyelitis 8 44 60
encephalitis &/or myelitis 8
encephalitis/myelitis nos 8
encephalomyelitis nos 8


Related Diseases for Encephalomyelitis

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17GeneCards, 18GeneDecks
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Diseases related to Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis31.2MMP19, MMP12, MMP8, MMP7
2lung cancer30.2MMP8, MMP7, MMP10, MMP13, MMP12, ELAVL3
3arthritis30.0MMP13, MMP17, MMP12, MMP8, MMP10
4hepatitis c29.9MMP7
5glioblastoma multiforme29.9MMP12, MMP7, MMP15
6rheumatoid arthritis29.7MMP13, MMP19, MMP8, MMP12, MMP11
7breast cancer29.7MMP11, MMP13, MMP7, MMP26, MMP17
8chondrosarcoma29.7MMP13, MMP7
9sensory peripheral neuropathy29.7ELAVL4, ELAVL3
10acute disseminated encephalomyelitis11.1
11chronic fatigue syndrome10.7
12encephalitis10.6
13western equine encephalitis10.5
14st. louis encephalitis10.5
15influenza10.4
16neuronitis10.4
17neuritis10.3
18pneumonia10.3
19louping ill10.3
20central nervous system disease10.3
21meningitis10.3
22nervous system disease10.3
23optic neuritis10.3
24malaria10.3
25measles10.2
26hepatitis10.2
27uveitis10.2
28myelitis10.2
29herpes simplex10.2
30postinfectious encephalomyelitis10.2
31subacute sclerosing panencephalitis10.2
32neuromyelitis optica10.2
33rabies10.2
34eastern equine encephalitis10.2
35immune-mediated encephalomyelitis10.2
36cerebritis10.1
37japanese encephalitis10.1
38hepatitis a10.1
39neuropathy10.1
40plasmodium malariae malaria10.1
41orchitis10.1
42viral encephalitis10.1
43stiff-person syndrome10.1
44leukemia10.1
45pertussis10.1
46poliomyelitis10.1
47retinitis10.1
48vasculitis10.1
49allergic encephalomyelitis10.1
50acute hemorrhagic leukoencephalitis10.0

Graphical network of the top 20 diseases related to Encephalomyelitis:



Diseases related to encephalomyelitis

Clinical Features for Encephalomyelitis

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Drugs & Therapeutics for Encephalomyelitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Encephalomyelitis

Search NIH Clinical Center for Encephalomyelitis

Search CenterWatch for Encephalomyelitis

Genetic Tests for Encephalomyelitis

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Anatomical Context for Encephalomyelitis

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32MalaCards
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MalaCards organs/tissues related to Encephalomyelitis:

32
T cells, Brain, Spinal cord, B cells, Bone, Bone marrow, Lung, Monocytes, Endothelial, Pituitary, Retina, Cortex, Testes, Myeloid, Breast, Thyroid, Skeletal muscle, Eye, Pineal, Nk cells, Prostate, Heart, Skin, Liver, Kidney, Lymph node, Spleen, Whole blood, Thymus, Cerebellum, Thalamus

Animal Models for Encephalomyelitis or affiliated genes

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Publications for Encephalomyelitis

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50PubMed
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Articles related to Encephalomyelitis:

(show top 50)    (show all 1888)
idTitleAuthorsYear
1
T cell-depleted splenocytes from mice pre-immunized with neuroantigen in incomplete Freund's adjuvant involved in protection from experimental autoimmune encephalomyelitis. (24220208)
2014
2
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. (24399752)
2014
3
Anti-high mobility group box 1 monoclonal antibody ameliorates experimental autoimmune encephalomyelitis. (23480183)
2013
4
Brachial plexitis preceding encephalomyelitis in a patient with West Nile virus infection. (24311412)
2013
5
Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis. (23869659)
2013
6
Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis. (24312270)
2013
7
Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice. (23137837)
2013
8
Extensive vascular remodeling in the spinal cord of pre-symptomatic experimental autoimmune encephalomyelitis mice; increased vessel expression of fibronectin and the I+5I^1 integrin. (24056042)
2013
9
Estrogen inhibits estrogen receptor I+-mediated rho-kinase expression in experimental autoimmune encephalomyelitis rats. (23401288)
2013
10
Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis. (23167594)
2013
11
Targeting estrogen receptor I^ in microglia and T cells to treat experimental autoimmune encephalomyelitis. (23401502)
2013
12
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. (24324591)
2013
13
Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis. (22749337)
2012
14
Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis. (23161666)
2012
15
Acute disseminated encephalomyelitis. (22914374)
2012
16
Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1. (23041842)
2012
17
Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis. (22447032)
2012
18
Acute disseminated encephalomyelitis following filarial infection. (21700730)
2012
19
Multiple linked quantitative trait loci within the Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in DBA/2J mice. (20861860)
2010
20
Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. (19533155)
2009
21
Fatal acute disseminated encephalomyelitis associated with cytomegalovirus infection. (21686809)
2009
22
IL-17 eliminates the therapeutic effects of myelin basic protein-induced nasal tolerance in experimental autoimmune encephalomyelitis by activating IL-6. (19055697)
2008
23
Differential diagnosis between acute disseminated encephalomyelitis and multiple sclerosis during the first episode. (18474751)
2008
24
Alexia without agraphia in a child with acute disseminated encephalomyelitis. (17372144)
2007
25
Alexia without agraphia in a child with acute disseminated encephalomyelitis. (16924040)
2006
26
IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes. (16087867)
2005
27
Acute disseminated encephalomyelitis associated with enteroviral infection. (15626964)
2004
28
Spinal motoneurone distress during experimental allergic encephalomyelitis. (15488028)
2004
29
Photopheresis affects the course of experimental allergic encephalomyelitis in Lewis rat. (12390665)
2002
30
A case of acute disseminated encephalomyelitis presenting hypersomnia with decreased hypocretin level in cerebrospinal fluid. (12269735)
2002
31
Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice. (11402297)
2001
32
Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis. (11435909)
2001
33
Dramatic improvement of severe acute disseminated encephalomyelitis after treatment with intravenous immunoglobulin in a three-year-old boy. (11221905)
2001
34
Neuroimmunology of multiple sclerosis and experimental allergic encephalomyelitis. (11359717)
2000
35
Gelatinase B in multiple sclerosis and experimental autoimmune encephalomyelitis. (10218093)
1999
36
Acute disseminated encephalomyelitis with probable measles vaccine failure. (10371390)
1999
37
Early detection of liposome brain localization in rat experimental allergic encephalomyelitis. (10229016)
1999
38
Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis. (10069427)
1999
39
Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells. (10453042)
1999
40
Acute disseminated encephalomyelitis after accidental injection of a hog vaccine: successful treatment with plasmapheresis. (9868420)
1998
41
Prevention of experimental allergic encephalomyelitis by an antibody to CD45RB. (9878118)
1998
42
Reciprocal stimulation between TNF-alpha and nitric oxide may exacerbate CNS inflammation in experimental autoimmune encephalomyelitis. (9726834)
1998
43
Perfluoro-15-crown-5-ether labelled macrophages in adoptive transfer experimental allergic encephalomyelitis. (9167839)
1997
44
Modulation of Outward K(+) Conductance Is a Post-Activational Event in Rat T Lymphocytes Responsible for the Adoptive Transfer of Experimental Allergic Encephalomyelitis. (11725140)
1997
45
Effects of water quality on the vector competence of Culex tarsalis (Diptera: Culicidae) for western equine encephalomyelitis (Togaviridae) and St. Louis encephalitis (Flaviviridae) viruses. (9439117)
1997
46
Evoked potential (EP) alterations in experimental allergic encephalomyelitis (EAE): early delays and latency reductions without plaques. (8742985)
1996
47
The relationship between human multiple sclerosis and rodent experimental allergic encephalomyelitis. (7544078)
1995
48
Unique T-cell receptor junctional sequences found in multiple sclerosis and T-cells mediating experimental allergic encephalomyelitis. (7544077)
1995
49
Acute disseminated encephalomyelitis and acute disseminated sclerosis; results of treatment with A.C.T.H. (13106426)
1953
50
Acute disseminated encephalomyelitis following herpes zoster, vaccination, and immunization. (15407725)
1949

Genetic Variations for Encephalomyelitis

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Expression for genes affiliated with Encephalomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalomyelitis

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Pathways for genes affiliated with Encephalomyelitis

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37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Encephalomyelitis

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Encephalomyelitis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1gm 60015912.2MMP20, MMP12, MMP8, MMP10, MMP23B, MMP23A
2gi 254023x5912.2MMP11, MMP7, MMP27, MMP25, MMP28, MMP19
3uk 3833675912.2MMP19, MMP20, MMP12, MMP8, MMP10, MMP23B
4batimastat44 59 1114.2MMP26, MMP10, MMP23B, MMP23A, MMP13, MMP24
5marimastat44 59 1114.2MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
6calcium44 49 11 2415.0MMP20, MMP12, MMP8, MMP10, MMP13, MMP24
7matrigel4411.1MMP13, MMP10, MMP12, MMP19, MMP7
8oligonucleotide4411.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
9vegf4411.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
10fibrinogen4411.1MMP13, MMP8, MMP12, MMP7, MMP26
11(4-aminophenyl)mercuric acetate4411.1MMP13, MMP10, MMP8, MMP7
12zinc44 2412.1MMP13, MMP8, MMP12, MMP7, MMP11, MMP26
13n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1112.0MMP20, MMP12, MMP10
14hydroxamate4411.0MMP12, MMP8, MMP13
15progesterone44 59 28 11 2414.9MMP15, MMP8, MMP7, MMP11, MMP26
16barbiturate4410.8MMP8, MMP13
17serine4410.8MMP12, MMP8, MMP10, MMP13
18clodronate44 49 1112.6MMP8, MMP13
19p0024410.6MMP13, MMP8, MMP7
20hocl4410.3MMP7, MMP8

GO Terms for genes affiliated with Encephalomyelitis

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16Gene Ontology
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Cellular components related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557811.6MMP26, MMP24, MMP13, MMP23B, MMP10, MMP8
2extracellular regionGO:00557610.9MMP13, MMP10, MMP8, MMP12, MMP20, MMP19
3extracellular matrixGO:03101210.7MMP21, MMP11, MMP15

Biological processes related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteolysisGO:00650811.7MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
2collagen catabolic processGO:03057411.4MMP27, MMP19, MMP20, MMP12, MMP8, MMP10
3extracellular matrix disassemblyGO:02261711.3MMP15, MMP11, MMP7, MMP19, MMP20, MMP12
4extracellular matrix organizationGO:03019810.9MMP15, MMP13, MMP10, MMP8, MMP12, MMP20
5positive regulation of catalytic activityGO:04308510.7MMP17, MMP24, MMP15

Molecular functions related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00827011.8MMP15, MMP24, MMP13, MMP23B, MMP10, MMP8
2metalloendopeptidase activityGO:00422211.7MMP20, MMP19, MMP28, MMP25, MMP27, MMP7
3calcium ion bindingGO:00550911.7MMP15, MMP21, MMP17, MMP11, MMP24, MMP13
4AU-rich element bindingGO:01709110.6ELAVL4, ELAVL3
5enzyme activator activityGO:00804710.4MMP15, MMP24, MMP17

Products for genes affiliated with Encephalomyelitis

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  • Antibodies
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Sources for Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet