MCID: ENC006
MIFTS: 55

Encephalomyelitis malady

Summaries for Encephalomyelitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number... more...

MalaCards: Encephalomyelitis, also known as encephalitis &/or myelitis, is related to multiple sclerosis and lung cancer. An important gene associated with Encephalomyelitis is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Matrix Metalloproteinases and GPCR Pathway. The compounds gm 6001 and gi 254023x have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Aliases & Classifications for Encephalomyelitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

encephalomyelitis 8 44 60
encephalitis &/or myelitis 8
encephalitis/myelitis nos 8
encephalomyelitis nos 8


Related Diseases for Encephalomyelitis

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17GeneCards, 18GeneDecks
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Diseases related to Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis31.2MMP19, MMP12, MMP8, MMP7
2lung cancer30.2MMP8, MMP7, MMP10, MMP13, MMP12, ELAVL3
3arthritis30.0MMP13, MMP17, MMP12, MMP8, MMP10
4hepatitis c29.9MMP7
5glioblastoma multiforme29.9MMP12, MMP7, MMP15
6rheumatoid arthritis29.7MMP13, MMP19, MMP8, MMP12, MMP11
7breast cancer29.7MMP11, MMP13, MMP7, MMP26, MMP17
8chondrosarcoma29.7MMP13, MMP7
9sensory peripheral neuropathy29.7ELAVL4, ELAVL3
10acute disseminated encephalomyelitis11.1
11chronic fatigue syndrome10.7
12encephalitis10.6
13western equine encephalitis10.5
14st. louis encephalitis10.5
15influenza10.4
16neuronitis10.4
17neuritis10.3
18pneumonia10.3
19louping ill10.3
20central nervous system disease10.3
21meningitis10.3
22nervous system disease10.3
23optic neuritis10.3
24malaria10.3
25measles10.2
26hepatitis10.2
27uveitis10.2
28myelitis10.2
29herpes simplex10.2
30postinfectious encephalomyelitis10.2
31subacute sclerosing panencephalitis10.2
32neuromyelitis optica10.2
33rabies10.2
34eastern equine encephalitis10.2
35immune-mediated encephalomyelitis10.2
36cerebritis10.1
37japanese encephalitis10.1
38hepatitis a10.1
39neuropathy10.1
40plasmodium malariae malaria10.1
41orchitis10.1
42viral encephalitis10.1
43stiff-person syndrome10.1
44leukemia10.1
45pertussis10.1
46poliomyelitis10.1
47retinitis10.1
48vasculitis10.1
49allergic encephalomyelitis10.1
50acute hemorrhagic leukoencephalitis10.0

Graphical network of the top 20 diseases related to Encephalomyelitis:



Diseases related to encephalomyelitis

Clinical Features for Encephalomyelitis

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Drugs & Therapeutics for Encephalomyelitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Encephalomyelitis

Search NIH Clinical Center for Encephalomyelitis

Search CenterWatch for Encephalomyelitis

Genetic Tests for Encephalomyelitis

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Anatomical Context for Encephalomyelitis

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32MalaCards
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MalaCards organs/tissues related to Encephalomyelitis:

32
T cells, Brain, Spinal cord, B cells, Bone, Bone marrow, Lung, Monocytes, Endothelial, Pituitary, Retina, Cortex, Testes, Breast, Myeloid, Eye, Skeletal muscle, Thyroid, Thalamus, Pineal, Whole blood, Lymph node, Nk cells, Spleen, Cerebellum, Prostate, Skin, Thymus, Kidney, Heart, Liver

Animal Models for Encephalomyelitis or affiliated genes

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Publications for Encephalomyelitis

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50PubMed
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Articles related to Encephalomyelitis:

(show top 50)    (show all 1888)
idTitleAuthorsYear
1
Effects of Zuogui Pill () and Yougui Pill () on the expression of brain-derived neurotrophic factor and cyclic adenosine monophosphate/protein kinase a signaling transduction pathways of axonal regeneration in model rats with experimental autoimmune encephalomyelitis. (23212569)
2014
2
Modulation of neurological deficits and expression of glutamate receptors during experimental autoimmune encephalomyelitis after treatment with selected antagonists of glutamate receptors. (23936777)
2013
3
The Kinetics of Myelin Antigen Uptake by Myeloid Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis. (24227784)
2013
4
C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model. (23352465)
2013
5
Low dose zymosan ameliorates both chronic and relapsing experimental autoimmune encephalomyelitis. (23010280)
2013
6
Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis. (24198809)
2013
7
Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. (24347169)
2013
8
Nogo-Receptor 1 Deficiency Has No Influence on Immune Cell Repertoire or Function during Experimental Autoimmune Encephalomyelitis. (24339996)
2013
9
Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis. (23772030)
2013
10
The adoption of chronic fatigue syndrome/myalgic encephalomyelitis case definitions to assess prevalence: a systematic review. (23683713)
2013
11
Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis. (23806004)
2013
12
Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB. (23602713)
2013
13
Human mesenchymal stem cells upregulate CD1dCD5(+) regulatory B cells in experimental autoimmune encephalomyelitis. (23899693)
2013
14
Pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (24340168)
2012
15
Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis. (22740327)
2012
16
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells. (23077616)
2012
17
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
18
Macrolide antibiotics aggravate experimental autoimmune encephalomyelitis and inhibit inducible nitric oxide synthase. (19811424)
2009
19
Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. (19218359)
2009
20
Spinal cord hydrolysate ameliorate immunological reaction in experimental allergic encephalomyelitis. (19325643)
2009
21
Acute disseminated encephalomyelitis. (18765104)
2008
22
Benefit of inhibiting SSAO in relapsing experimental autoimmune encephalomyelitis. (17393060)
2007
23
Gene-based delivery of IFN-beta is efficacious in a murine model of experimental allergic encephalomyelitis. (16800783)
2006
24
A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation. (16914558)
2006
25
MRI and proton MR spectroscopy in acute disseminated encephalomyelitis. (15711984)
2005
26
The transformation of pediatric gliomatosis cerebri to cerebellar glioblastoma multiforme presenting as supra- and infratentorial acute disseminated encephalomyelitis. Case report. (16206737)
2005
27
Acute disseminated encephalomyelitis associated with Borrelia burgdorferi. (15164203)
2004
28
Matrix metalloproteases activity and ultrastructural changes in the early phase of experimental allergic encephalomyelitis. The effect of oral treatment with spinal cord hydrolysate [correction of hydrolisate] proteins in Lewis rat. The pilot study. (15266785)
2004
29
Acute disseminated encephalomyelitis following leptospirosis. (15636341)
2004
30
Bilateral transient amaurosis following Mycoplasma pneumoniae infection: a manifestation of acute disseminated encephalomyelitis. (12855991)
2003
31
Acute disseminated encephalomyelitis in adults: a reappraisal of clinical, CSF, EEG, and MRI findings. (11993533)
2002
32
Beneficial effect of modified peptide inhibitor of alpha4 integrins on experimental allergic encephalomyelitis in Lewis rats. (11782963)
2002
33
Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rats. (11529923)
2001
34
The effect of short-term treatment with interferon beta 1a on acute experimental allergic encephalomyelitis. (11680640)
2001
35
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis. (10841980)
2000
36
Inhibition of experimental allergic encephalomyelitis with an antibody that recognizes a novel antigen expressed on lymphocytes, endothelial cells, and microglia. (10744067)
2000
37
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
38
Fulminant form of acute disseminated encephalomyelitis: successful treatment with hypothermia. (10426155)
1999
39
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis. (9811889)
1998
40
Acute disseminated encephalomyelitis-like syndrome following group A beta-hemolytic streptococcal infection. (9701488)
1998
41
Suppression of acute experimental allergic encephalomyelitis in Lewis rats with a mycophenolic acid derivative. (9362104)
1997
42
Encephalitogenic epitopes of myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein for experimental allergic encephalomyelitis induction in Biozzi ABH (H-2Ag7) mice share an amino acid motif. (8609422)
1996
43
Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat. (7545648)
1995
44
Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. (7593560)
1995
45
Brainstem multiple sclerosis in an 11-year-old child presenting as acute disseminated encephalomyelitis. (8576560)
1995
46
Acute disseminated encephalomyelitis following HTLV-I associated myelopathy. (1506865)
1992
47
Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection. (1705992)
1991
48
Endogenous myelin basic protein-serum factors (MBP-SFS) and anti-MBP antibodies in a patient with post-herpes simplex virus acute disseminated encephalomyelitis. (6195314)
1983
49
Louping-ill encephalomyelitis in the sheep. II. Distribution of virus and lesions in nervous tissue. (4945207)
1971
50
The antiviral activity of acridines in eastern equine encephalomyelitis, Rift Valley fever and psittacosis in mice, and lymphogranuloma venereum in chick-embryos. (13329343)
1956

Genetic Variations for Encephalomyelitis

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Expression for genes affiliated with Encephalomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalomyelitis

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Pathways for genes affiliated with Encephalomyelitis

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37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Encephalomyelitis

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Encephalomyelitis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1gm 60015912.2MMP20, MMP12, MMP8, MMP10, MMP23B, MMP23A
2gi 254023x5912.2MMP11, MMP7, MMP27, MMP25, MMP28, MMP19
3uk 3833675912.2MMP19, MMP20, MMP12, MMP8, MMP10, MMP23B
4batimastat44 59 1114.2MMP26, MMP10, MMP23B, MMP23A, MMP13, MMP24
5marimastat44 59 1114.2MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
6calcium44 49 11 2415.0MMP20, MMP12, MMP8, MMP10, MMP13, MMP24
7matrigel4411.1MMP13, MMP10, MMP12, MMP19, MMP7
8oligonucleotide4411.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
9vegf4411.1MMP13, MMP10, MMP8, MMP12, MMP7, MMP11
10fibrinogen4411.1MMP13, MMP8, MMP12, MMP7, MMP26
11(4-aminophenyl)mercuric acetate4411.1MMP13, MMP10, MMP8, MMP7
12zinc44 2412.1MMP13, MMP8, MMP12, MMP7, MMP11, MMP26
13n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1112.0MMP20, MMP12, MMP10
14hydroxamate4411.0MMP12, MMP8, MMP13
15progesterone44 59 28 11 2414.9MMP15, MMP8, MMP7, MMP11, MMP26
16barbiturate4410.8MMP8, MMP13
17serine4410.8MMP12, MMP8, MMP10, MMP13
18clodronate44 49 1112.6MMP8, MMP13
19p0024410.6MMP13, MMP8, MMP7
20hocl4410.3MMP7, MMP8

GO Terms for genes affiliated with Encephalomyelitis

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16Gene Ontology
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Cellular components related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557811.6MMP26, MMP24, MMP13, MMP23B, MMP10, MMP8
2extracellular regionGO:00557610.9MMP13, MMP10, MMP8, MMP12, MMP20, MMP19
3extracellular matrixGO:03101210.7MMP21, MMP11, MMP15

Biological processes related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteolysisGO:00650811.7MMP26, MMP21, MMP17, MMP11, MMP7, MMP27
2collagen catabolic processGO:03057411.4MMP27, MMP19, MMP20, MMP12, MMP8, MMP10
3extracellular matrix disassemblyGO:02261711.3MMP15, MMP11, MMP7, MMP19, MMP20, MMP12
4extracellular matrix organizationGO:03019810.9MMP15, MMP13, MMP10, MMP8, MMP12, MMP20
5positive regulation of catalytic activityGO:04308510.7MMP17, MMP24, MMP15

Molecular functions related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00827011.8MMP15, MMP24, MMP13, MMP23B, MMP10, MMP8
2metalloendopeptidase activityGO:00422211.7MMP20, MMP19, MMP28, MMP25, MMP27, MMP7
3calcium ion bindingGO:00550911.7MMP15, MMP21, MMP17, MMP11, MMP24, MMP13
4AU-rich element bindingGO:01709110.6ELAVL4, ELAVL3
5enzyme activator activityGO:00804710.4MMP15, MMP24, MMP17

Products for genes affiliated with Encephalomyelitis

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  • Antibodies
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Sources for Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet