Encephalomyelitis malady

Wikipedia: Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number...⁴⁴ more...

MalaCards: Encephalomyelitis, also known as encephalitis/myelitis nos (disorder), is related to allergic encephalomyelitis and acute disseminated encephalomyelitis. An important gene associated with Encephalomyelitis is ELAVL4 (ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4), and among its related pathways are Inhibition of Matrix Metalloproteinases and Metalloproteases in connective tissue degradation. The compounds ivig and ribavirin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Descriptions:

encephalomyelitis 6 32 43 encephalitis/myelitis nos (disorder) 6 encephalomyelitis nos (disorder) 6 encephalitis &/or myelitis 6

encephalomyelitis (disorder) 6 encephalitis/myelitis nos 6 encephalomyelitis nos 6 encephalitis 43

Diseases related to encephalomyelitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 962)

id	Related Disease	Score	Top Affiliating Genes
1	allergic encephalomyelitis	40.4	BMP6, CIITA, FTH1, MOG, CD86, CD80
2	acute disseminated encephalomyelitis	36.4	CNTF, SAG, MPZ, MOG, IL10, AQP4
3	encephalitis	35.6	CNP, CNR1, CNTF, VEGFA, VCAM1, BMP6
4	limbic encephalitis	35.0	IL6, IFNG, AMPH, ELAVL3, GAD1, GAD2
5	multiple sclerosis	34.1	MOG, CD40, IL1B, MBP, CCR5, IFNG
6	immunodeficiency	33.8	VIP, BMP6, CIITA, SAG, CFLAR, MPZ
7	viral encephalitis	33.8	VEGFA, VCAM1, MOG, CD40LG, IL10, IL1B
8	optic neuritis	30.7	CNP, SAG, MPZ, MOG, CD86, CD40LG
9	neuritis	30.0	CNP, BMP6, CIITA, SAG, S100A8, MPO
10	aicardi-goutieres syndrome	29.7	AQP4, APP, MBP, MAPT, ALB, NOTCH3
11	subacute sclerosing panencephalitis	29.6	S100B, MOG, MMP9, IRF1, IL10, IL12B
12	chronic fatigue syndrome	29.5	PDCD2, VIP, IL10, IL1R1, IL2, IL2RB
13	bacterial meningitis	29.3	MMP8, IL1B, CCL4, CCL3, CR1, CXCL1
14	cerebral malaria	29.2	VCAM1, IL10, IL12B, IL1B, IL1R1, IFNG
15	arthritis	29.0	VIP, MMP3, IL17A, IL1B, IL6, TNF
16	hepatitis	28.9	IL2RB, FASLG, FAS, CCL20, IFNB1, ALB
17	paraneoplastic neurologic disorders	28.9	DAZL, PNMA1, ELAVL1, ELAVL2, ELAVL3, ELAVL4
18	meningoencephalitis	28.9	CD40LG, IL6, APP, MBP, CCL5, ALB
19	west nile virus	28.8	CFH, CD40LG, IL1B, IL6, ANPEP, CCR5
20	neurologic diseases	28.5	CNTF, MPZ, MOG, CD80, CD40, MMP9
21	transverse myelitis	28.5	CD40LG, IL17A, AQP4, MBP, AMPH
22	malaria	28.5	CD40LG, IRF1, IL10, IL4, IFNG, TNF
23	vaccinia	28.5	KITLG, CIITA, S100B, CD80, FLT3LG, FLT3
24	rheumatoid arthritis	28.2	CIITA, CD40, IL10, IL1B, IL2, IL21
25	viral meningitis	28.1	IL16, IL6, CCL5, NTF3, CXCR3
26	lyme disease	28.1	CLDN11, CIITA, CFH, CD40LG, MMP12, MMP9
27	hepatitis c	28.0	CIITA, CD40LG, MMP1, IRF1, IL10, IL12B
28	gliosis	27.8	CNTF, S100B, MPZ, IL6, AQP4, APP
29	acquired immunodeficiency syndrome	27.7	VEGFA, VCAM1, CIITA, CD40LG, IL10, IL1B
30	glioblastoma	27.6	VEGFA, CLDN5, CD80, CD44, MMP2, FLT3LG
31	temporal lobe epilepsy	27.6	BDNF, GRM1, AQP4, NTF3, GAD1, GAD2
32	adrenoleukodystrophy	27.5	PDE4A, S100B, MPZ, MOG, IL1B, IL4
33	rabies	27.5	VIP, VEGFA, VEGFB, MPZ, CD86, ITGB3
34	hepatic encephalopathy	27.1	S100B, IL18, IL6, AQP4, ALB, GLS
35	paraneoplastic syndromes	27.1	VIP, SAG, IL2, IL5, IL6, AMPH
36	febrile seizures	27.0	CNR1, BDNF, MMP9, IL10, IL1B, IL1R1
37	diabetes insipidus	26.9	S100B, MPO, AQP4, CALCA, CRH, OXER1
38	trypanosomiasis	26.7	VCAM1, BMP6, CFLAR, IL10, IL12B, IL18
39	breast cancer	26.1	NCOA3, VEGFA, MMP1, MMP13, MMP2, MMP3
40	meningitis	25.9	VIP, VEGFA, BMP6, S100B, MPO, MPZ
41	herpes simplex	25.7	VEGFA, BDNF, LGALS3, S100B, CFLAR, CD86
42	thymoma	25.5	VIP, MPO, CD55, MMP14, MMP2, MMP9
43	uveitis	25.4	VEGFA, BMP6, SAG, S100A8, MPO, CD40LG
44	hepatitis a	25.2	CD40LG, IL10, IL1B, IL2, APP, IFN1@
45	parkinson's disease	25.1	CNR1, CNTF, PARK7, BDNF, CIITA, SAG
46	neurodegenerative disease	24.6	CNR1, CNTF, PARK7, BDNF, MPZ, GRM1
47	astrocytoma	24.2	CNR1, VEGFA, VEGFB, VCAM1, BMP6, PARK7
48	lung carcinoma	24.1	VEGFA, CIITA, S100A8, CFH, CFLAR, CDKN1C
49	medulloblastoma	24.0	PDE4A, VIP, VEGFB, BDNF, SAG, S100B
50	neurodegeneration	23.7	CNR1, CNTF, VIP, VEGFA, BMP6, PARK7

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to encephalomyelitis:

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MGI Mouse Phenotypes related to encephalomyelitis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	11.7	NCOA3, PDE4A, CNP, CNTF, LGALS3, CIITA
2	hematopoietic system phenotype	MP:0005397	10.7	CNTF, LGALS3, SAFB, CFLAR, FTH1, CD86
3	endocrine/exocrine gland phenotype	MP:0005379	10.5	CNP, BTN1A1, CD40LG, CDKN1C, IL2, IL2RB
4	respiratory system phenotype	MP:0005388	10.5	CNP, BDNF, CD1D, ITGB3, IL12B, AQP4
5	nervous system phenotype	MP:0003631	10.3	PDE4A, CNP, CNR1, CNTF, CNTNAP1, KITLG
6	renal/urinary system phenotype	MP:0005367	10.0	NCOA3, CFH, CD1D, CDKN1C, CD55, MMP14
7	craniofacial phenotype	MP:0005382	9.8	NCOA3, KITLG, BDNF, CDKN1C, ITGA4, MMP16
8	digestive/alimentary phenotype	MP:0005381	9.6	NCOA3, CNP, KITLG, VEGFA, BDNF, LGALS3
9	embryogenesis phenotype	MP:0005380	9.5	NCOA3, PDCD2, CFLAR, ITGA4, ITGAV, ITGB7
10	liver/biliary system phenotype	MP:0005370	9.4	NCOA3, VEGFA, SAFB, FTH1, CD1D, IL1R1
11	limbs/digits/tail phenotype	MP:0005371	9.3	KITLG, VEGFA, CDKN1C, CD44, MMP13, MMP14
12	other phenotype	MP:0005395	8.9	CNR1, CD40LG, ITGB3, MMP14, IL2, APP
13	adipose tissue phenotype	MP:0005375	8.8	NCOA3, CNR1, MMP19, GRM1, IL18, IL1R1
14	normal phenotype	MP:0002873	8.7	VIP, VEGFA, BDNF, CIITA, CFH, CDKN1C
15	reproductive system phenotype	MP:0005389	8.6	NCOA3, CNP, CNTNAP1, BTN1A1, VIP, VEGFA
16	no phenotypic analysis	MP:0003012	8.4	CNR1, VEGFA, VCAM1, BDNF, ATP2B2, CD44
17	integument phenotype	MP:0010771	8.4	NCOA3, CNR1, KITLG, BTN1A1, BDNF, S100B
18	tumorigenesis	MP:0002006	8.3	NCOA3, KITLG, CD44, ITGAL, ITGAV, ITGB3
19	behavior/neurological phenotype	MP:0005386	8.2	NCOA3, CNP, CNR1, CNTF, CNTNAP1, VIP
20	skeleton phenotype	MP:0005390	8.1	CNP, CNR1, KITLG, VEGFA, BMP6, LGALS3
21	vision/eye phenotype	MP:0005391	8.1	CNP, CNTNAP1, KITLG, VEGFA, VEGFB, CLDN11
22	mortality/aging	MP:0010768	7.8	PDCD2, CNP, CNR1, CNTNAP1, KITLG, VEGFA
23	growth/size phenotype	MP:0005378	7.8	NCOA3, PDCD2, CNP, CNR1, CNTNAP1, KITLG
24	cellular phenotype	MP:0005384	7.2	NCOA3, CNR1, CNTF, KITLG, VEGFA, VCAM1
25	cardiovascular system phenotype	MP:0005385	6.4	PDE4A, KITLG, VEGFA, VEGFB, VCAM1, CLDN5
26	muscle phenotype	MP:0005369	6.3	NCOA3, CNP, CNTF, CNTNAP1, VEGFA, CFLAR
27	homeostasis/metabolism phenotype	MP:0005376	5.7	NCOA3, CNP, CNR1, CNTF, KITLG, VIP

Articles related to encephalomyelitis:

(show top 50)    (show all 358)

id	Title	Authors	Year	Affiliating Genes
1	Antibodies to MOG are transient in childhood acute di sseminated encephalomyelitis. (21795651)	PrAPbstel A.K.... Derfuss T.	2011	MOG
2	Central nervous system expression of interferon regul atory factor 1 regulates experimental autoimmune encephalomyelitis. (20177805)	Ren Z.... Balabanov R.	2010	IRF1
3	Smad7 in T cells drives T helper 1 responses in multi ple sclerosis and experimental autoimmune encephalomyelitis. (20354004)	Kleiter I.... Waisman A.	2010	SMAD7
4	Progesterone treatment reduces disease severity and i ncreases IL-10 in experimental autoimmune encephalomyelitis. (20153059)	Yates M.A.... Offner H.	2010	IL10
5	Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. (19218359)	Kalyvas A.... David S.	2009	PLA2G2A
6	A 25-year-old woman with primary SjAPgren syndrome wh o developed optic neuritis and encephalomyelitis associated with an anti-aquapo rin 4 antibody (19928688)	Kato H.... Kawamura M.	2009	MBP
7	Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulati ng Th17 cells. (19819554)	Chen S.J.... Sytwu H.K.	2009	TNFRSF6B
8	Disseminated encephalomyelitis in adults. (18703274)	Brinar V.V.... Poser C.M.	2008	AQP4
9	Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. (18991353)	Wang Y.... Khoury S.J.	2008	GLI1
10	Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. (19017937)	Murugaiyan G.... Weiner H.L.	2008	SPP1, ITGAV, CD44
11	PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis. (18645614)	Yang Y.... Racke M.K.	2008	PPARA
12	Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. (18250475)	Jurynczyk M.... Selmaj K.	2008	PRKCQ, NOTCH3
13	HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma. (18490779)	Mangalam A.... David C.	2008	IFNG, HLA-DQB1
14	IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. (18424707)	Liu J.... Medof M.E.	2008	IFNG, CD55, C3AR1
15	LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. (17906634)	Mi S.... Wu W.	2007	LINGO1
16	Restrictive and diversifying elements of the anti-myelin/oligodendrocyte glycoprotein antibody response in primate experimental allergic encephalomyelitis. (16528499)	von Budingen H.C.... Genain C.P.	2006	MOG
17	Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats. (15544619)	Morgan B.P.... Neal J.W.	2004	C5AR1
18	Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice. (14975585)	Copray S.... Boddeke E.	2004	NGFR
19	Regulation of neuroinflammation: the role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis. (15108349)	Klein R.S.	2004	CXCR3, CXCL10
20	Tolerance induction by molecular mimicry: prevention and suppression of experimental autoimmune encephalomyelitis with the milk protein butyrophilin. (14978022)	Mana P.... Linares D.	2004	MOG, BTN1A1
21	Bilateral anterior optic neuritis in adult measles infection without encephalomyelitis. (12429258)	Azuma M.... Okada A.A.	2002	CD40LG
22	Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. (11431007)	Scott G.S.... Hooper D.C.	2001	EPRS
23	Suppression of experimental autoimmune encephalomyelitis by intravenously administered polyclonal immunoglobulins. (11040073)	Achiron A.... Miron S.	2000	MBP
24	Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression. (11114975)	Kanwar J.R.... Krissansen G.W.	2000	ITGB7, MADCAM1
25	Coupling of peripheral tolerance to endogenous interleukin 10 promotes effective modulation of myelin-activated T cells and ameliorates experimental allergic encephalomyelitis. (10859329)	Legge K.L.... Zaghouani H.	2000	IL10
26	The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis. (11128602)	Stefferl A.... Linington C.	2000	MOG
27	Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. (10940928)	Rottman J.B.... Hancock W.W.	2000	CCL3
28	Acute disseminated encephalomyelitis in a female with hereditary neuropathy with susceptibility to pressure palsy. (10788748)	Muneuchi J.... Hara T.	2000	PMP22
29	Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. (10443879)	Raine C.S.... Genain C.P.	1999	MOG
30	Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis. (10209044)	Ruiz P.J.... Steinman L.	1999	MBP
31	Correlation between MRI and clinico-pathological manifestations in Lewis rats protected from experimental allergic encephalomyelitis by acylated synthetic peptide of myelin basic protein. (10372527)	Karlik S.J.... Strejan G.	1999	MBP
32	Oligodendrocyte-specific protein peptides induce experimental autoimmune encephalomyelitis in SJL/J mice. (10358205)	Stevens D.B.... Bronstein J.M.	1999	CLDN11
33	Tumour necrosis factor-alpha and lymphotoxin-alpha in the pathology of experimental autoimmune encephalomyelitis: is either one resp onsible or is there another ligand-mediating disease? (9923636)	Willenborg D.O.... Ramshaw I.A.	1998	TNF
34	Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta. (9266413)	Kojima K.... Linington C.	1997	S100B
35	Antiamphiphysin antibodies with small-cell lung carcinoma and paraneoplastic encephalomyelitis. (8619552)	Dropcho E.J.	1996	AMPH
36	In vivo administration of IL-4 induces TGF-beta-producing cells and protects animals from experimental autoimmune encephalomyelitis. (8611000)	Inobe J.I.... Weiner H.L.	1996	IL4
37	Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. (8598395)	Yu M.... Tuohy V.K.	1996	IFNB1
38	CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. (8759711)	Perrin P.J.... Racke M.K.	1996	CTLA4
39	Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. (8833909)	Elliott E.A.... Mueller J.P.	1996	MBP, PLP1
40	Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. (7593560)	Martin D.... Near S.L.	1995	MBP
41	Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA. (7898713)	Liu J.... Furneaux H.	1995	ELAVL4
42	A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. (7621871)	Mendel I.... Ben-Nun A.	1995	MBP, MOG
43	Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. (7737302)	Kerlero de Rosbo N.... Ben-Nun A.	1995	MBP, MOG, PLP1
44	Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. (7515395)	Cross A.H.... Tilton R.G.	1994	NOS2
45	Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. (8222755)	Muresu R.... Siniscalco M.	1994	ELAVL4
46	Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. VI. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization. (7689596)	Miller A.... Weiner H.L.	1993	MBP
47	Hierarchy of effects of the MHC and T cell receptor b eta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-i nduced demyelinating disease. (1836484)	Kappel C.A.... Kim B.S.	1991	TRB@
48	Therapeutic effects of 15-deoxyspergualin in acute an d chronic relapsing experimental allergic encephalomyelitis (EAE) as models for multiple sclerosis (MS). (1841035)	Schorlemmer H.U.... Seiler F.R.	1991	MBP
49	T cell receptor peptide therapy triggers autoregulati on of experimental encephalomyelitis. (1989076)	Offner H.... Vandenbark A.A.	1991	MBP
50	NMR studies in experimental allergic encephalomyelitis: factors which contribute to T1 and T2 values. (1693744)	Karlik S.J.... Noseworthy J.H.	1990	MBP

Genes related to encephalomyelitis according to GeneCards:

(show top 50)    (show all 247)

id	Symbol	Description	Score	GeneCards Section Context
1	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4	11.0	Domains & Families, Aliases & Descriptions, Publications
2	ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	11.0	Domains & Families, Publications, Summaries
3	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications, Summaries
4	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Summaries
5	MMP23B	matrix metallopeptidase 23B	11.0	Summaries
6	MMP21	matrix metallopeptidase 21	11.0	Summaries
7	MMP27	matrix metallopeptidase 27	11.0	Summaries
8	MMP19	matrix metallopeptidase 19	11.0	Summaries
9	MMP28	matrix metallopeptidase 28	11.0	Summaries
10	MMP25	matrix metallopeptidase 25	11.0	Summaries
11	MMP26	matrix metallopeptidase 26	11.0	Summaries
12	MMP20	matrix metallopeptidase 20	11.0	Summaries
13	MMP24	matrix metallopeptidase 24 (membrane-inserted)	11.0	Summaries
14	MMP17	matrix metallopeptidase 17 (membrane-inserted)	11.0	Summaries
15	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications, Summaries
16	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0	Summaries
17	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Summaries
18	MMP15	matrix metallopeptidase 15 (membrane-inserted)	11.0	Summaries
19	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Summaries
20	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Summaries
21	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Summaries
22	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Summaries
23	MMP16	matrix metallopeptidase 16 (membrane-inserted)	11.0	Summaries
24	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Summaries
25	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Summaries, Publications
26	MBP	myelin basic protein	11.0	Publications
27	MOG	myelin oligodendrocyte glycoprotein	11.0	Publications
28	IL10	interleukin 10	11.0	Publications
29	TNF	tumor necrosis factor	11.0	Publications
30	PLP1	proteolipid protein 1	11.0	Publications
31	GRK6	G protein-coupled receptor kinase 6	11.0	Publications
32	AQP4	aquaporin 4	11.0	Publications
33	MPZ	myelin protein zero	11.0	Publications
34	ADRBK1	adrenergic, beta, receptor kinase 1	11.0	Publications
35	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
36	NTF3	neurotrophin 3	11.0	Publications
37	EPRS	glutamyl-prolyl-tRNA synthetase	11.0	Publications
38	STAT4	signal transducer and activator of transcription 4	11.0	Publications
39	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	11.0	Publications
40	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
41	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
42	CD86	CD86 molecule	11.0	Publications
43	CD80	CD80 molecule	11.0	Publications
44	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
45	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
46	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
47	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
48	IL4	interleukin 4	11.0	Publications
49	TGFB2	transforming growth factor, beta 2	11.0	Publications
50	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications

Pathways related to encephalomyelitis according to GeneDecks:

(show top 50)    (show all 191)

id	Pathway	Score	Top Affiliating Genes
1	Inhibition of Matrix Metalloproteinases36	12.4	MMP1, MMP10, MMP11, MMP12, MMP13, MMP14
2	Metalloproteases in connective tissue degradation10	12.0	MMP1, MMP10, MMP12, MMP13, MMP14, MMP15
3	UPA-UPAR Pathway36	11.7	ITGA2, ITGA4, ITGAL, ITGAV, ITGB3, ITGB7
4	Pancreatic Adenocarcinoma36	11.3	KITLG, VEGFB, BMP6, BDNF, MMP1, MMP10
5	THC Differentiation Pathway36	11.0	CD86, IL10, IL12B, IL18, IL2, IL4
6	Th1 Differentiation37	11.0	CD86, CD80, IL10, IL12B, IL18, IL2
7	Chemokine signaling pathway20	11.0	GRK6, CCL8, CCL4, CCL7, CCR6, CCL2
8	Akt Signaling36	10.9	VEGFB, CD80, ITGA2, ITGAL, FLT3, IL10
9	RAR-Gamma-RXR-Alpha Degradation36	10.9	CD80, IL16, IL2, IL21, IL23A, IL7
10	JNK Pathway36	10.9	KITLG, VEGFB, BMP6, CD80, FLT3, IL1R1
11	Intestinal immune network for IgA production20	10.8	CD86, CD40LG, CD80, CD40, ITGA4, ITGB7
12	Toxoplasmosis20	10.8	CIITA, CD40LG, CD40, IL10, IL12B, CCR5
13	IL-6 Pathway36	10.8	BMP6, CD80, IL10, IL12B, IL16, IL18
14	Graft-versus-host disease20	10.8	CD86, CD80, IL2, FASLG, HLA-A, HLA-DPA1
15	Tuberculosis20	10.7	CIITA, IL10, IL12B, IL18, IL1B, IL23A
16	Chemokine Signaling36	10.6	GRK6, CCL8, CCL4, CCL7, CCR6, CCL2
17	PPAR Pathway36	10.5	KITLG, VEGFB, ITGA2, ITGA4, ITGAL, ITGAV
18	Glioma Invasiveness36	10.5	KITLG, VEGFB, BMP6, BDNF, CD44, ITGA4
19	Influenza A20	10.4	CIITA, IL12B, IL18, IL1B, IL6, FASLG
20	Regulation of eIF4 and p70S6K36	10.4	CD80, ITGA2, ITGA4, ITGAL, ITGB3, ITGB7
21	Th17 Differentiation37	10.3	CD86, CD80, IL12B, IL17A, IL1B, IL1R1
22	Rheumatoid arthritis20	10.3	VEGFA, VEGFB, CD86, CD80, ITGAL, MMP1
23	NFAT Signaling and Lymphocyte Interactions36	10.3	BMP6, CD80, IL12B, IL16, IL2, IL23A
24	Endothelin-1 Signaling Pathway36	10.2	BMP6, CD80, FLT3, IL10, IL12B, IL16
25	PAK Pathway36	10.2	KITLG, VEGFB, BMP6, BDNF, CD80, IL10
26	Molecular Mechanisms of Cancer36	10.2	KITLG, BMP6, BDNF, CFLAR, CD80, ITGA2
27	ERK Signaling36	10.1	KITLG, VEGFB, BMP6, CD80, ITGA4, ITGAL
28	Malaria20	10.1	VCAM1, CD40LG, CD40, ITGAL, IL10, IL18
29	p38 Signaling36	10.1	KITLG, VEGFB, BMP6, BDNF, CD80, FLT3
30	African trypanosomiasis20	10.0	VCAM1, IL10, IL12B, IL18, IL1B, IL6
31	Chagas disease (American trypanosomiasis)20	10.0	CFLAR, IL10, IL12B, IL1B, IL2, IL6
32	Cytokine Network36	10.0	IL10, IL12B, IL16, IL18, IL1B, IL2
33	NF-KappaB Family Pathway36	10.0	KITLG, VEGFB, BMP6, BDNF, IL1B, IL1R1
34	PEDF Induced Signaling36	10.0	BMP6, BDNF, CFLAR, CD80, IL10, IL12B
35	Rho Family GTPases36	10.0	KITLG, VEGFB, BMP6, BDNF, CD80, ITGA2
36	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	IL12B, IL17A, IL1B, IL21, IL21R, IL23A
37	Leishmaniasis20	9.9	ITGA4, IL10, IL12B, IL1B, IL4, IFNG
38	Autoimmune thyroid disease20	9.9	CD86, CD40LG, CD80, CD40, IL10, IL2
39	Antioxidant Action of Vitamin-C36	9.8	KITLG, VEGFB, BMP6, BDNF, CD80, IL10
40	Allograft rejection20	9.8	CD86, CD40LG, CD80, CD40, IL10, IL12B
41	MAPK Family Pathway36	9.7	KITLG, VEGFB, BMP6, BDNF, CD80, IL10
42	JAK-STAT Pathway36	9.7	KITLG, VEGFB, BMP6, BDNF, CD80, FLT3
43	TGF-Beta Pathway36	9.6	KITLG, VEGFB, BMP6, BDNF, CD80, IL10
44	Hematopoietic cell lineage20	9.5	KITLG, CD1D, CD44, CD55, ITGA2, ITGA4
45	all-trans-Retinoic Acid Signaling in Brain36	9.4	BMP6, CD80, IL10, IL12B, IL16, IL18
46	PGC1Alpha Pathway36	9.4	BMP6, CD80, IL12B, IL16, IL18, IL1B
47	MIF Mediated Glucocorticoid Regulation36	9.3	BMP6, CD80, IL10, IL12B, IL16, IL18
48	MIF Regulation of Innate Immune Cells36	9.3	BMP6, CD80, IL10, IL12B, IL16, IL18
49	Glucocorticoid Receptor Signaling36	9.2	NCOA3, BMP6, CD80, IL10, IL12B, IL16
50	Tec Kinases Signaling36	9.2	KITLG, VEGFB, BMP6, BDNF, CD80, ITGA2

Compounds related to encephalomyelitis according to GeneDecks:

(show top 50)    (show all 435)

id	Compound	Score	Top Affiliating Genes
1	ivig32	11.2	SAG, FASLG, MBP, CCL4, CCR5, IFNB1
2	ribavirin32 34 9 9	13.9	CD40LG, MMP1, MMP2, MMP9, IL10, IL18
3	glycosaminoglycan32	10.7	CFH, CD44, MMP13, MMP16, MMP8, CCR1
4	nicotine32 34 9 9	13.6	CCR7, CACNA1B, CRH
5	budesonide32 42 9 9	13.5	PDE4A, KITLG, CCL11, F2RL1, POMC
6	cytochalasin d32 42	11.5	KITLG, VCAM1, CD44, ITGA4, ITGAL, MMP1
7	polyinosinic-polycytidylic acid32	10.5	VCAM1, CIITA, CD40, IRF1, IL10, IL12B
8	bromodeoxyuridine32	10.5	NCOA3, CNP, CNTF, KITLG, BMP6, BDNF
9	8-isoprostane32	10.4	VCAM1, MPO, MMP2, MMP9, IL10, IL6
10	glucose32	10.2	PDE4A, CNTF, SAFB, S100B, CFLAR, ITGA2
11	sb 20358032 42	11.1	VEGFA, VCAM1, BMP6, MMP1, MMP13, MMP2
12	allergens32	10.0	LGALS3, CIITA, SAFB, S100A8, CD86, CD40LG
13	neopterin32	10.0	CD40LG, CD40, IL10, IL18, IL1B, IL1R1
14	atorvastatin32 34 9 18 9	14.0	VEGFA, VCAM1, BMP6, CD40LG, CD40, CD55
15	simvastatin32 34 42 9 18 9	14.9	KITLG, VEGFA, VCAM1, BMP6, CIITA, CD40
16	hydrocortisone32 9 9	11.9	KITLG, BMP6, CD40, MMP1, MMP2, IL10
17	forskolin32 42 9 9	12.8	PDE4A, CNP, CNTF, VIP, BMP6, BDNF
18	5 aminosalicylic acid32	9.8	MPO, IL10, IL12B, IL1B, MADCAM1, CCL2
19	n acetylcysteine32	9.8	VCAM1, BDNF, CD40, MMP1, MMP12, MMP2
20	calcium32 9 18 9	12.6	PDE4A, CNR1, CNTF, KITLG, VIP, CLDN11
21	il-1232	9.6	CD86, CD40LG, IL10, IL12B, IL18, IL1B
22	tacrolimus32 34 9 9	12.5	BMP6, CFH, CD86, CD40, ITGA4, ITGAL
23	nitric oxide32 9 18 9	12.5	PDE4A, CNTF, KITLG, VCAM1, BMP6, LGALS3
24	polysaccharide32	9.5	NCOA3, KITLG, VCAM1, BMP6, LGALS3, CFH
25	epinephrine32 9 18 9	12.5	PDE4A, KITLG, VIP, BMP6, BDNF, ITGA2
26	prednisolone32 9 9	11.4	KITLG, VIP, VCAM1, BMP6, MPO, CD40
27	doxorubicin32 34 9 9	12.4	KITLG, BMP6, BDNF, CFLAR, CD40LG, CD40
28	methotrexate32 34 42 9 9	13.3	KITLG, BMP6, S100A8, CD40, MMP1, MMP2
29	alpha tocopherol32	9.2	VCAM1, ITGAL, MMP1, MMP19, MMP9, IL4
30	calcitriol32 42 9 18 9	13.1	NCOA3, KITLG, BMP6, S100A8, CD44, ITGAL
31	fibrinogen32	9.1	VCAM1, LGALS3, CFH, CD40LG, CD40, ITGA2
32	cysteine32	9.1	PARK7, LGALS3, SAFB, S100A8, S100B, CFH
33	mg 13232 42	10.0	CFLAR, IL1B, FASLG, FAS, MAPT, IKBKB
34	atp32	9.0	PDE4A, BDNF, LGALS3, SAFB, SAG, S100B
35	pdtc32	8.9	VCAM1, CFLAR, CD40, MMP1, MMP2, MMP9
36	cyclosporin a32 42	9.9	PDE4A, KITLG, VIP, CIITA, SAG, S100B
37	adenylate32	8.9	PDE4A, CNP, CNR1, CNTF, KITLG, VIP
38	herbimycin a32 42	9.8	KITLG, VCAM1, BMP6, CD40LG, CD40, MMP1
39	heparin32 9 18 9	11.6	KITLG, VEGFB, LGALS3, SAG, CFH, MPO
40	arginine32	8.5	NCOA3, PDE4A, CNR1, CNTF, VIP, SAFB
41	cholesterol32 9 18 9	11.5	KITLG, VCAM1, CLDN3, BDNF, CIITA, S100A8
42	histamine32 18	9.4	PDE4A, CNR1, CNTF, KITLG, VIP, VCAM1
43	prostacyclin32	8.4	PDE4A, VIP, VEGFA, VCAM1, BMP6, IL10
44	vitamin d32	8.3	NCOA3, BMP6, LGALS3, SAFB, CD44, ITGB3
45	glutamate32	8.0	CNP, CNR1, VIP, BMP6, LGALS3, SAFB
46	alanine32	8.0	CNR1, CNTF, KITLG, VIP, VCAM1, BMP6
47	oxygen32 18	8.8	KITLG, VEGFB, BLVRA, PARK7, BDNF, LGALS3
48	ibuprofen32 9 18 9	10.4	VCAM1, BMP6, BDNF, MMP1, MMP2, MMP3
49	dexamethasone32 42 34 9 9	10.8	PDE4A, KITLG, VIP, VEGFA, VCAM1, BMP6
50	cisplatin32 34 9 9	9.5	KITLG, VEGFA, BMP6, BDNF, LGALS3, CFH

Cellular components related to encephalomyelitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	11.6	VEGFA, MMP24, MMP25, MMP26, MMP27, MMP28
2	MHC class II protein complex	GO:042613	10.7	HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-DRB1
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.3	HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-A
4	integrin complex	GO:008305	10.2	ITGB7, ITGB3, ITGAV, ITGAL, ITGA4, ITGA2
5	external side of plasma membrane	GO:009897	9.8	CD40LG, CD40, CD44, ITGA2, ITGA4, ITGAL
6	integral to plasma membrane	GO:005887	9.8	ITGB3, MMP14, MMP15, MMP16, MMP17, MMP24
7	membrane raft	GO:045121	9.5	DPP4, TLR4, PTPRC, TNFRSF1B, TNF, IKBKB
8	cell surface	GO:009986	9.4	ITGA2, TNFRSF4, CR1, NGFR, HBEGF, TGFB1
9	extracellular space	GO:005615	8.2	CNP, CNTF, KITLG, VEGFA, VEGFB, HMOX1
10	plasma membrane	GO:005886	7.5	CACNA1B, PTPRC, CYTH1, CTLA4, NTF3, SMAD7
11	extracellular region	GO:005576	7.3	C3, GDNF, IL1R1, CCL3, CCL5, IFNB1

Biological processes related to encephalomyelitis according to GeneDecks:

(show top 50)    (show all 105)

id	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:006508	12.5	MMP2, MMP19, MMP17, MMP16, MMP15, MMP14
2	collagen catabolic process	GO:030574	11.9	MMP9, MMP11, MMP13, MMP16, MMP19, MMP2
3	extracellular matrix disassembly	GO:022617	11.7	MMP14, MMP1, MMP2, MMP11, MMP13, MMP16
4	extracellular matrix organization	GO:030198	11.2	MMP10, MMP9, MMP8, MMP7, MMP3, MMP2
5	chemotaxis	GO:006935	11.1	CCR1, CCR5, CCR8, CCL11, CCL2, CCR6
6	immune response	GO:006955	11.1	CCL4, CIITA, BMP6, FTH1, CD86, IL16
7	cell surface receptor signaling pathway	GO:007166	11.0	C5, IFNB1, PRMT1, AGER, PTPRC, PTK2B
8	cellular response to interferon-gamma	GO:071346	10.9	HLA-DPA1, CCL3, CCL2, IL12B, AQP4, IL18
9	positive regulation of osteoclast differentiation	GO:045672	10.9	TNF, IL12B, IL17A, IL23A, CCR1, IFNG
10	defense response to virus	GO:051607	10.9	IRF1, CD40, CD86, PTPRC, F2RL1, IFNG
11	humoral immune response	GO:006959	10.9	CCL2, LTA, TNF, IL6, IL7, CCR6
12	positive regulation of interleukin-17 production	GO:032740	10.9	IL18, IL2, TGFB1, PRKCQ, IL23A, IL21
13	chemokine-mediated signaling pathway	GO:070098	10.8	CCR6, PTK2B, CXCR3, CCR1, CCL2, CCR8
14	cellular calcium ion homeostasis	GO:006874	10.7	CCL13, CCL3, CCL5, CCL1, CD40, CCR1
15	interferon-gamma-mediated signaling pathway	GO:060333	10.7	HLA-DRA, IRF1, VCAM1, CIITA, CD44, SOCS3
16	cell-cell signaling	GO:007267	10.7	CCL20, CCL3, CCL13, CCL5, CALCA, ESR2
17	positive regulation of interleukin-12 production	GO:032735	10.6	IFNG, HSPD1, TLR4, IL23A, IL12B, CD40
18	positive regulation of MHC class II biosynthetic process	GO:045348	10.6	CD40LG, IL10, IL4, IFNG, TLR4, CIITA
19	positive regulation of T cell proliferation	GO:042102	10.6	CCL5, IL6, IL12B, PRKCQ, PTPRC, IFNG
20	positive regulation of inflammatory response	GO:050729	10.5	CCL3, IL2, TLR4, PLA2G2A, PTGER4, IL23A
21	positive regulation of interleukin-10 production	GO:032733	10.4	TLR4, HSPD1, IL4, IL23A, IL12B, CD40LG
22	leukocyte cell-cell adhesion	GO:007159	10.4	PTPRC, CALCA, ICAM1, ITGAL, ITGA4, CD40LG
23	positive regulation of cell proliferation	GO:008284	10.3	TGFB2, FLT3LG, TGFB1, IL6, CXCL10, FLT3
24	regulation of immune response	GO:050776	10.3	ITGAL, ITGB7, MADCAM1, ICAM2, ICAM1, HLA-A
25	B cell proliferation	GO:042100	10.2	PTPRC, HSPD1, IFNB1, IL10, CD40LG, CD40
26	elevation of cytosolic calcium ion concentration	GO:007204	10.2	IL2, CCR6, CCR8, CD55, CCR5, C5AR1
27	positive regulation of interferon-gamma production	GO:032729	10.2	IL18, IL12B, CD40LG, IL1B, IL2, IL23A
28	cytokine-mediated signaling pathway	GO:019221	10.1	VCAM1, CCR1, IFNB1, IFNG, ICAM1, HLA-DPA1
29	signal transduction	GO:007165	10.1	PDE4A, POMC, CXCL13, CXCL10, CXCL1, STAT3
30	positive regulation of B cell proliferation	GO:030890	10.1	TNFRSF4, CD40LG, CD40, IL2, IL4, IL5
31	cell adhesion	GO:007155	10.1	APP, IL2, CNTNAP1, ITGB7, KITLG, VCAM1
32	response to ethanol	GO:045471	9.9	SOD1, STAT3, CNR1, TACR1, TH, ICAM1
33	virus-host interaction	GO:019048	9.9	TGFB1, STAT3, CXCR4, MMP1, LTBR, HLA-A
34	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	TNF, TLR4, TGFB1, CCL5, CCL3, CCL2
35	aging	GO:007568	9.8	CCL5, CALCA, HMGCR, TGFB2, PRKCQ, SOCS3
36	response to lipopolysaccharide	GO:032496	9.8	LTA, TLR4, S100A8, CXCL10, CNR1, MMP9
37	innate immune response	GO:045087	9.7	AGER, CR1, TLR4, PPARG, F2RL1, IFNB1
38	response to heat	GO:009408	9.6	SOCS3, MMP9, IRF1, IL1B, CCL2, PRKCQ
39	positive regulation of fever generation	GO:031622	9.5	PLA2G4A, CCL5, IL1B, CNR1, PTGS2, TNF
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.5	IL17A, STAT4, GDNF, POMC, CIITA, TGFB1
41	response to drug	GO:042493	9.4	IL10, IL4, FAS, CCL2, CCL5, IKBKB
42	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	CSPG4, TLR4, PTK2B, IL6, IL5, VEGFB
43	positive regulation vascular endothelial growth factor production	GO:010575	9.0	PTGS2, C3AR1, C3, HPSE, IL1B, TGFB1
44	response to hypoxia	GO:001666	8.9	LTA, NOS2, PPARA, TNF, HMOX2, CCL2
45	positive regulation of apoptotic process	GO:043065	8.9	TLR4, SOD1, TGFB2, HSPD1, IDO1, IL1B
46	response to vitamin D	GO:033280	8.9	CXCL10, TGFB2, IL1B, PTGS2, PLA2G4A, TGFB1
47	anti-apoptosis	GO:006916	8.9	HMOX1, TNF, TNFRSF6B, NRG1, NGF, NGFR
48	response to glucocorticoid stimulus	GO:051384	8.9	PLA2G4A, PTGS2, TNF, CCL5, CCL2, FAS
49	blood coagulation	GO:007596	8.4	PECAM1, F2RL1, IFNB1, APP, IRF1, MMP1
50	inflammatory response	GO:006954	8.3	HDAC9, C3AR1, C3, C5, CXCR4, CXCL2

Molecular functions related to encephalomyelitis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	metalloendopeptidase activity	GO:004222	12.4	MMP10, MMP1, MMP11, MMP25, MMP24, MMP23B
2	calcium ion binding	GO:005509	11.6	MMP24, MMP25, MMP27, MMP28, MMP3, MMP8
3	chemokine activity	GO:008009	10.8	C5, CCL8, CCL4, CXCL2, CXCL13, CXCL10
4	MHC class II receptor activity	GO:032395	10.7	HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DPA1
5	tumor necrosis factor receptor binding	GO:005164	10.6	LTB, LTA, TNFSF13B, TNF, FADD, FASLG
6	C-C chemokine receptor activity	GO:016493	10.5	CCR7, CCR1, CCR5, CCR8, CCR6
7	CCR1 chemokine receptor binding	GO:031726	10.5	CCL4, CCL7, CCL3, CCL5
8	CCR5 chemokine receptor binding	GO:031730	10.2	STAT3, CCL5, CCL3, CCL4
9	receptor binding	GO:005102	10.2	TNFSF13B, HLA-A, CALCA, HSPA8, F2RL1, CCL13
10	receptor activity	GO:004872	10.0	ICAM1, F2RL1, TREM2, TNFRSF6B, NGFR, AGER
11	cytokine activity	GO:005125	9.7	TGFB2, IL27, IL23A, IL21, IL2, IL1B
12	heparin binding	GO:008201	9.4	CXCL13, HBEGF, PTPRC, CCL5, CCL2, CCL7
13	growth factor activity	GO:008083	9.3	CXCL1, TGFB2, TGFB1, THPO, HBEGF, NGF
14	protein binding	GO:005515	4.7	HPSE, MAPT, FAS, FADD, FASLG, APP