MCID: ENC006
MIFTS: 52

Encephalomyelitis malady

Neuronal diseases category
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Summaries for Encephalomyelitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number... more...

MalaCards: Encephalomyelitis, also known as encephalitis &/or myelitis, is related to multiple sclerosis and lung cancer. An important gene associated with Encephalomyelitis is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Cell adhesion ECM remodeling and Degradation of the extracellular matrix. The compounds hocl and hydroxamate have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Aliases & Classifications for Encephalomyelitis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

encephalomyelitis 8 45 62
encephalitis &/or myelitis 8
encephalitis/myelitis nos 8
encephalomyelitis nos 8


Related Diseases for Encephalomyelitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Encephalomyelitis:



Diseases related to encephalomyelitis

Symptoms for Encephalomyelitis

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Drugs & Therapeutics for Encephalomyelitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Encephalomyelitis

Search NIH Clinical Center for Encephalomyelitis

Genetic Tests for Encephalomyelitis

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Anatomical Context for Encephalomyelitis

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33MalaCards
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MalaCards organs/tissues related to Encephalomyelitis:

33
T cells, Brain, Spinal cord, B cells, Bone, Bone marrow, Lung, Monocytes, Endothelial, Pituitary, Retina, Cortex, Testes, Breast, Myeloid, Eye, Skeletal muscle, Thyroid, Thalamus, Pineal, Whole blood, Lymph node, Nk cells, Spleen, Cerebellum, Prostate, Skin, Thymus, Kidney, Heart, Liver

Animal Models for Encephalomyelitis or affiliated genes

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Publications for Encephalomyelitis

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52PubMed
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Articles related to Encephalomyelitis:

(show top 50)    (show all 1868)
idTitleAuthorsYear
1
Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. (23302888)
2013
2
PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis. (24355567)
2013
3
Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations. (23602715)
2013
4
Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis. (23688679)
2013
5
Neurological Images and the Predictors for Neurological Sequelae of Epidemic Herpangina/Hand-Foot-Mouth Disease with Encephalomyelitis. (24258524)
2013
6
A case of acute disseminated encephalomyelitis following influenza virus A-H1N1 infection. (24056381)
2013
7
Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring. (23777566)
2013
8
Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis. (22749337)
2012
9
Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 mice. (22964785)
2012
10
Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document. (22181560)
2012
11
Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (20876155)
2011
12
Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1. (21235533)
2011
13
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
14
Experimental study of implantation of neurotropin-3 modified olfactory ensheathing cells in experimental allergic encephalomyelitis]. (20017332)
2009
15
Macrolide antibiotics aggravate experimental autoimmune encephalomyelitis and inhibit inducible nitric oxide synthase. (19811424)
2009
16
Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis. (19389933)
2009
17
p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation. (19458044)
2009
18
IL-21 modulates CD4+ CD25+ regulatory T-cell homeostasis in experimental autoimmune encephalomyelitis. (18052963)
2008
19
Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. (17407101)
2007
20
Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis. (17465017)
2007
21
Acute disseminated encephalomyelitis in classic dengue. (17568897)
2007
22
Plasmapheresis in acute disseminated encephalomyelitis. (16465015)
2006
23
Increased levels of bioactive IL-16 correlate with disease activity during relapsing experimental autoimmune encephalomyelitis (EAE). (16271292)
2005
24
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis. (16120465)
2005
25
Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians. (12538312)
2003
26
Progressive encephalomyelitis with rigidity presenting as a stiff-person syndrome. (12039424)
2002
27
Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL mice. (11585623)
2001
28
Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice. (11402297)
2001
29
Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. (10779748)
2000
30
Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72-85 with a human MBP(87-99) analogue and effects of cyclic peptides. (11003134)
2000
31
Experimental allergic encephalomyelitis animal models for analyzing features of multiple sclerosis. (10729911)
2000
32
QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. (9988264)
1999
33
A gene therapy or purified CTLA4IgG treatment of experimental allergic encephalomyelitis. (10642893)
1999
34
A novel antigen-toxin chimeric protein: myelin basic protein-pseudomonas exotoxin (MBP-PE 40) for treatment of experimental autoimmune encephalomyelitis. (10424450)
1999
35
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. (10465150)
1999
36
Galectin-3/MAC-2 in experimental allergic encephalomyelitis. (10619568)
1999
37
Gelatinase B in multiple sclerosis and experimental autoimmune encephalomyelitis. (10218093)
1999
38
Acute disseminated encephalomyelitis associated with tetanus vaccination. (10343155)
1999
39
Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. (9689425)
1998
40
Microvascular and cellular responses in the retina of rats with acute experimental allergic encephalomyelitis (EAE). (9669699)
1998
41
B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. (9794370)
1998
42
Abnormalities of cardiac repolarization in multiple sclerosis: relationship with a model of allergic encephalomyelitis in rat. (9626255)
1998
43
Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. (9203563)
1997
44
Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. (9394784)
1997
45
Experimental allergic encephalomyelitis in non-human primates: MRI and MRS may predict the type of brain damage. (7547186)
1995
46
Eicosenoids Modify Experimental Allergic Encephalomyelitis. (11854849)
1995
47
Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth factor-beta and interleukin-10. (7489740)
1995
48
The 70-kDa heat shock cognate protein (HSC70) is a major constituent of the central nervous system and is up-regulated only at the mRNA level in acute experimental autoimmune encephalomyelitis. (8376991)
1993
49
Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. (1349810)
1992
50
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. (4133960)
1974

Variations for Encephalomyelitis

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Expression for genes affiliated with Encephalomyelitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Encephalomyelitis

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Pathways for genes affiliated with Encephalomyelitis

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50PathCards, 60Thomson Reuters, 12EMD Millipore, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database
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Compounds for genes affiliated with Encephalomyelitis

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45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Encephalomyelitis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1hocl4510.1MMP7, MMP8
2hydroxamate4510.1MMP8, MMP12
3n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid45 1111.0MMP20, MMP10, MMP12
4(4-aminophenyl)mercuric acetate4510.0MMP7, MMP10, MMP8
5matrigel459.8MMP19, MMP10, MMP12, MMP7
6oligonucleotide459.5MMP7, MMP12, MMP10, MMP8
7fibrinogen459.4MMP7, MMP12, MMP8, MMP26
8zinc45 2410.3MMP26, MMP8, MMP12, MMP7
9vegf459.3MMP7, MMP12, MMP10, MMP8
10progesterone45 29 61 24 1113.0MMP26, MMP15, MMP8, MMP7
11calcium45 51 24 118.9MMP25, MMP27, MMP7, MMP12, MMP28, MMP10
12uk 383367615.3MMP25, MMP27, MMP23A, MMP23B, MMP7, MMP12
13gi 254023x615.3MMP12, MMP28, MMP10, MMP20, MMP8, MMP19
14gm 6001615.3MMP25, MMP27, MMP23A, MMP23B, MMP7, MMP12
15batimastat45 61 117.2MMP26, MMP25, MMP27, MMP23A, MMP23B, MMP7
16marimastat45 61 117.2MMP15, MMP26, MMP21, MMP19, MMP8, MMP25

GO Terms for genes affiliated with Encephalomyelitis

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16Gene Ontology
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Cellular components related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6MMP7, MMP12, MMP10, MMP20, MMP8, MMP19
2proteinaceous extracellular matrixGO:0055786.0MMP25, MMP27, MMP23B, MMP7, MMP12, MMP28

Biological processes related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301988.5MMP12, MMP10, MMP20, MMP8, MMP19, MMP15
2extracellular matrix disassemblyGO:0226178.2MMP7, MMP12, MMP10, MMP20, MMP8, MMP19
3proteolysisGO:0065087.5MMP26, MMP25, MMP19, MMP8, MMP20, MMP10
4collagen catabolic processGO:0305747.5MMP27, MMP7, MMP12, MMP10, MMP20, MMP8

Molecular functions related to Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AU-rich element bindingGO:0170919.9ELAVL3, ELAVL4
2calcium ion bindingGO:0055096.1MMP28, MMP12, MMP27, MMP25, MMP10, MMP20
3metalloendopeptidase activityGO:0042225.3MMP26, MMP25, MMP15, MMP21, MMP19, MMP8
4zinc ion bindingGO:0082705.2MMP21, MMP19, MMP8, MMP20, MMP10, MMP28

Products for genes affiliated with Encephalomyelitis

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  • Antibodies
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  • Antibodies

Sources for Encephalomyelitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet