IIAE4
MCID: ENC036
MIFTS: 23

Encephalopathy, Acute, Infection-Induced, 4 (IIAE4) malady

Categories: Genetic diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Encephalopathy, Acute, Infection-Induced, 4

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Aliases & Descriptions for Encephalopathy, Acute, Infection-Induced, 4:

Name: Encephalopathy, Acute, Infection-Induced, 4 52 70
Encephalopathy, Acute, Infection-Induced, Susceptibility to, 4 52
Acute Necrotizing Encephalopathy of Childhood 54
Isolated Acute Necrotizing Encephalopathy 54
Encephalopathy Acute Infection-Induced 4 70
 
Encephalitis, Viral 39
Isolated Ane 54
Iiae4 70
Anec 54

Characteristics:

Orphanet epidemiological data:

54
acute necrotizing encephalopathy of childhood:
Inheritance: Not applicable; Age of onset: Childhood

HPO:

64
encephalopathy, acute, infection-induced, 4:
Inheritance: autosomal dominant inheritance, autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 614212
Orphanet54 ORPHA263524
ICD10 via Orphanet31 G31.8
MedGen37 C3280160
MeSH39 D018792
ICD1030 A86, A85.8

Summaries for Encephalopathy, Acute, Infection-Induced, 4

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OMIM:52 Acute encephalopathy is a severe neurologic complication of an infection that usually occurs in children. It is... (614212) more...

MalaCards based summary: Encephalopathy, Acute, Infection-Induced, 4, also known as encephalopathy, acute, infection-induced, susceptibility to, 4, is related to viral encephalitis and infection-induced acute encephalopathy 4, susceptibility, and has symptoms including seizures, coma and encephalopathy. An important gene associated with Encephalopathy, Acute, Infection-Induced, 4 is CPT2 (Carnitine Palmitoyltransferase 2). Affiliated tissues include brain, and related mouse phenotype Weakly decreased NFAT1-GFP nuclear translocation.

UniProtKB/Swiss-Prot:70 Encephalopathy, acute, infection-induced, 4: A severe neurologic complication of an infection. It manifests within days in otherwise healthy children after common viral infections, without evidence of viral infection of the brain or inflammatory cell infiltration. In affected children, high-grade fever is accompanied within 12 to 48 hours by febrile convulsions, often leading to coma, multiple-organ failure, brain edema, and high morbidity and mortality. The infections are usually viral, particularly influenza, although other viruses and even mycoplasma have been found to cause the disorder.

Related Diseases for Encephalopathy, Acute, Infection-Induced, 4

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Graphical network of the top 20 diseases related to Encephalopathy, Acute, Infection-Induced, 4:



Diseases related to encephalopathy, acute, infection-induced, 4

Symptoms & Phenotypes for Encephalopathy, Acute, Infection-Induced, 4

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Symptoms by clinical synopsis from OMIM:

614212

Clinical features from OMIM:

614212

Human phenotypes related to Encephalopathy, Acute, Infection-Induced, 4:

 64
id Description HPO Frequency HPO Source Accession
1 seizures64 HP:0001250
2 coma64 HP:0001259
3 encephalopathy64 HP:0001298
4 cerebral edema64 HP:0002181

GenomeRNAi Phenotypes related to Encephalopathy, Acute, Infection-Induced, 4 according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00359-A9.1CPT2, RANBP2

Drugs & Therapeutics for Encephalopathy, Acute, Infection-Induced, 4

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Encephalopathy, Acute, Infection-Induced, 4


Cochrane evidence based reviews: encephalitis, viral

Genetic Tests for Encephalopathy, Acute, Infection-Induced, 4

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Anatomical Context for Encephalopathy, Acute, Infection-Induced, 4

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MalaCards organs/tissues related to Encephalopathy, Acute, Infection-Induced, 4:

36
Brain

Publications for Encephalopathy, Acute, Infection-Induced, 4

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Variations for Encephalopathy, Acute, Infection-Induced, 4

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Expression for genes affiliated with Encephalopathy, Acute, Infection-Induced, 4

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Search GEO for disease gene expression data for Encephalopathy, Acute, Infection-Induced, 4.

Pathways for genes affiliated with Encephalopathy, Acute, Infection-Induced, 4

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GO Terms for genes affiliated with Encephalopathy, Acute, Infection-Induced, 4

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Cellular components related to Encephalopathy, Acute, Infection-Induced, 4 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00057399.1CPT2, RANBP2

Sources for Encephalopathy, Acute, Infection-Induced, 4

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet