IIAE4
MCID: ENC036
MIFTS: 23

Encephalopathy, Acute, Infection-Induced, 4 (IIAE4) malady

Categories: Genetic diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Encephalopathy, Acute, Infection-Induced, 4

Aliases & Descriptions for Encephalopathy, Acute, Infection-Induced, 4:

Name: Encephalopathy, Acute, Infection-Induced, 4 54 66
Encephalopathy, Acute, Infection-Induced, Susceptibility to, 4 54
Acute Necrotizing Encephalopathy of Childhood 56
Isolated Acute Necrotizing Encephalopathy 56
Encephalopathy Acute Infection-Induced 4 66
Encephalitis, Viral 42
Isolated Ane 56
Iiae4 66
Anec 56

Characteristics:

Orphanet epidemiological data:

56
acute necrotizing encephalopathy of childhood
Inheritance: Not applicable; Age of onset: Childhood;

HPO:

32
encephalopathy, acute, infection-induced, 4:
Inheritance autosomal recessive inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 614212
Orphanet 56 ORPHA263524
ICD10 via Orphanet 34 G31.8
MedGen 40 C3280160
MeSH 42 D018792
ICD10 33 A86 A85.8

Summaries for Encephalopathy, Acute, Infection-Induced, 4

OMIM : 54 Acute encephalopathy is a severe neurologic complication of an infection that usually occurs in children. It is... (614212) more...

MalaCards based summary : Encephalopathy, Acute, Infection-Induced, 4, also known as encephalopathy, acute, infection-induced, susceptibility to, 4, is related to viral encephalitis and infection-induced acute encephalopathy 4, susceptibility, and has symptoms including seizures, coma and cerebral edema. An important gene associated with Encephalopathy, Acute, Infection-Induced, 4 is CPT2 (Carnitine Palmitoyltransferase 2). Affiliated tissues include brain, and related phenotype is Weakly decreased NFAT1-GFP nuclear translocation.

UniProtKB/Swiss-Prot : 66 Encephalopathy, acute, infection-induced, 4: A severe neurologic complication of an infection. It manifests within days in otherwise healthy children after common viral infections, without evidence of viral infection of the brain or inflammatory cell infiltration. In affected children, high-grade fever is accompanied within 12 to 48 hours by febrile convulsions, often leading to coma, multiple-organ failure, brain edema, and high morbidity and mortality. The infections are usually viral, particularly influenza, although other viruses and even mycoplasma have been found to cause the disorder.

Related Diseases for Encephalopathy, Acute, Infection-Induced, 4

Diseases related to Encephalopathy, Acute, Infection-Induced, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
id Related Disease Score Top Affiliating Genes
1 viral encephalitis 11.5
2 infection-induced acute encephalopathy 4, susceptibility 11.4
3 herpes simplex encephalitis 1 10.9
4 question mark ears, isolated 10.4
5 encephalitis 10.3
6 japanese encephalitis 9.9
7 st. louis encephalitis 9.9
8 anterior segment mesenchymal dysgenesis 9.8 CPT2 RANBP2
9 acute necrotizing encephalopathy 9.8
10 encephalopathy 9.8
11 meningitis 9.6
12 venezuelan equine encephalitis 9.6
13 transverse myelitis 9.6
14 viral meningitis 9.6
15 meningitis and encephalitis 9.6
16 acute transverse myelitis 9.6
17 myelitis 9.6
18 herpes simplex 9.6
19 candida glabrata 9.1
20 mycobacterium abscessus 9.1
21 hiv-1 9.1
22 acth deficiency 9.1
23 pneumonia 9.1

Graphical network of the top 20 diseases related to Encephalopathy, Acute, Infection-Induced, 4:



Diseases related to Encephalopathy, Acute, Infection-Induced, 4

Symptoms & Phenotypes for Encephalopathy, Acute, Infection-Induced, 4

Symptoms by clinical synopsis from OMIM:

614212

Clinical features from OMIM:

614212

Human phenotypes related to Encephalopathy, Acute, Infection-Induced, 4:

32
id Description HPO Frequency HPO Source Accession
1 seizures 32 HP:0001250
2 coma 32 HP:0001259
3 cerebral edema 32 HP:0002181
4 encephalopathy 32 HP:0001298

GenomeRNAi Phenotypes related to Encephalopathy, Acute, Infection-Induced, 4 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Weakly decreased NFAT1-GFP nuclear translocation GR00359-A 8.62 CPT2 RANBP2

Drugs & Therapeutics for Encephalopathy, Acute, Infection-Induced, 4

Search Clinical Trials , NIH Clinical Center for Encephalopathy, Acute, Infection-Induced, 4

Cochrane evidence based reviews: encephalitis, viral

Genetic Tests for Encephalopathy, Acute, Infection-Induced, 4

Anatomical Context for Encephalopathy, Acute, Infection-Induced, 4

MalaCards organs/tissues related to Encephalopathy, Acute, Infection-Induced, 4:

39
Brain

Publications for Encephalopathy, Acute, Infection-Induced, 4

Variations for Encephalopathy, Acute, Infection-Induced, 4

Expression for Encephalopathy, Acute, Infection-Induced, 4

Search GEO for disease gene expression data for Encephalopathy, Acute, Infection-Induced, 4.

Pathways for Encephalopathy, Acute, Infection-Induced, 4

GO Terms for Encephalopathy, Acute, Infection-Induced, 4

Cellular components related to Encephalopathy, Acute, Infection-Induced, 4 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 8.62 CPT2 RANBP2

Sources for Encephalopathy, Acute, Infection-Induced, 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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