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MCID: END030
MIFTS: 59

End Stage Renal Failure

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for End Stage Renal Failure

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MalaCards integrated aliases for End Stage Renal Failure:

Name: End Stage Renal Failure 37 12 14
Chronic Kidney Disease Stage 5 69
Stage 5 Chronic Kidney Disease 28
End Stage Renal Disease 12
Kidney Failure, Chronic 69

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:783
ICD10 32 N18.5
UMLS 69 C2316810
Sources

Summaries for End Stage Renal Failure

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MalaCards based summary : End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to frasier syndrome and nephrotic syndrome, type 1, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with End Stage Renal Failure is UMOD (Uromodulin), and among its related pathways/superpathways are Selenium Micronutrient Network and Dilated cardiomyopathy (DCM). The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 72 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

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Related Diseases for End Stage Renal Failure

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Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 374)
# Related Disease Score Top Affiliating Genes
1 frasier syndrome 32.8 NPHS1 NPHS2 WT1
2 nephrotic syndrome, type 1 32.8 NPHS1 NPHS2 WT1
3 alport syndrome, x-linked 31.6 CD79A COL4A5 MYH9
4 peritonitis 31.0 ALB CRP IL6 TNF
5 secondary hyperparathyroidism of renal origin 30.7 ALB EPO PTH
6 poems syndrome 30.2 EPO IL6 TNF
7 endocarditis 30.1 ALB CRP IL6 TNF
8 infective endocarditis 30.1 CRP IL6 TNF
9 leptospirosis 30.1 CRP IL6 TNF
10 brucellosis 30.1 CRP IL6 TNF
11 peripheral artery disease 30.0 ACE CRP CST3 IL6
12 autosomal dominant polycystic kidney disease 30.0 ACE AGT ALB PKD1
13 peripheral vascular disease 29.9 ACE ALB CRP IL6
14 aortic valve disease 2 29.9 ACE AGT CRP
15 arteries, anomalies of 29.7 ACE AGT ALB CRP IL6 TNF
16 gingivitis 29.7 CD79A IL6 TNF
17 diabetes mellitus 29.7 ACE AGT ALB CRP IL6 TNF
18 microvascular complications of diabetes 3 29.7 ACE AGT ALB NPHS1 TGFB1
19 pyelonephritis 29.7 ACE ALB CRP IL6 TNF UMOD
20 nephrosclerosis 29.6 ACE NPHS2 TGFB1
21 interstitial nephritis 29.5 ACE AGT ALB ANKS6 CRP UMOD
22 glomerulonephritis 29.2 ALB CD79A COL4A5 NPHS1 NPHS2 TGFB1
23 posterior urethral valves 28.9 ACE AGT IL6 TGFB1 TNF
24 liver disease 28.8 ALB IL6 TF TGFB1 TNF
25 kidney disease 27.5 ACE ALB COL4A5 CST3 EPO MYH9
26 chronic kidney failure 25.7 ACE AGT ALB CD79A COL4A5 CRP
27 nephronophthisis 11.3
28 glomerulopathy with fibronectin deposits 2 11.3
29 medullary cystic kidney disease 1 11.2
30 nephrotic syndrome, type 2 11.2
31 medullary cystic kidney disease 2 11.2
32 nephronophthisis-like nephropathy 1 11.2
33 coenzyme q10 deficiency, primary, 6 11.2
34 nephronophthisis 20 11.2
35 nephrotic syndrome 15 11.2
36 glomerulopathy with fibronectin deposits 1 11.0
37 hematuria, benign familial 11.0
38 hyperuricemic nephropathy, familial juvenile, 1 11.0
39 hemolytic uremic syndrome, atypical 1 11.0
40 nephrotic syndrome, type 4 11.0
41 nephrotic syndrome, type 3 11.0
42 nephronophthisis 9 11.0
43 nephrotic syndrome, type 6 11.0
44 nephrotic syndrome, type 5, with or without ocular abnormalities 11.0
45 nephronophthisis 15 11.0
46 nephronophthisis 16 11.0
47 nephrotic syndrome, type 11 11.0
48 nephrotic syndrome, type 12 11.0
49 nephrotic syndrome, type 13 11.0
50 nephrotic syndrome 14 11.0

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to End Stage Renal Failure
Sources

Symptoms & Phenotypes for End Stage Renal Failure

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UMLS symptoms related to End Stage Renal Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to End Stage Renal Failure:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.38 ACE AGT ALB CD79A COL4A5 CRP
2 cardiovascular system MP:0005385 10.37 ACE AGT ANKS6 COL4A5 CRP CST3
3 growth/size/body region MP:0005378 10.27 NPHS2 PKD1 PTH TF TGFB1 TNF
4 cellular MP:0005384 10.22 ALB CD79A EPO IL6 MYH9 PKD1
5 hematopoietic system MP:0005397 10.21 ACE CD79A COL4A5 EPO IL6 MYH9
6 immune system MP:0005387 10.21 UMOD WT1 ACE AGT CD79A COL4A5
7 mortality/aging MP:0010768 10.19 AGT ALB ANKS6 COL4A5 CST3 EPO
8 adipose tissue MP:0005375 10.11 ACE AGT COL4A5 IL6 PKD1 TGFB1
9 liver/biliary system MP:0005370 10.06 TNF WT1 PKD1 TGFB1 ACE AGT
10 muscle MP:0005369 9.81 AGT ALB CST3 EPO IL6 PKD1
11 neoplasm MP:0002006 9.61 ACE ALB CD79A CST3 IL6 PKD1
12 renal/urinary system MP:0005367 9.44 NPHS1 NPHS2 PKD1 TGFB1 UMOD WT1
Sources

Drugs & Therapeutics for End Stage Renal Failure

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Drugs for End Stage Renal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 735)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4 79902-63-9 54454
3
Peginterferon alfa-2b Approved Phase 4,Phase 1 215647-85-1, 99210-65-8
4
Ribavirin Approved Phase 4,Phase 3,Phase 1,Phase 2 36791-04-5 37542
5
Nitric Oxide Approved Phase 4 10102-43-9 145068
6
Digoxin Approved Phase 4 20830-75-5 2724385 30322
7
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
8
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 616-91-1 12035
9
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
10
Ticagrelor Approved Phase 4,Phase 3,Phase 1,Phase 2 274693-27-5 9871419
11
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
13
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
14
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
16
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 104987-11-3 445643 439492
17
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
18
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
19
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
20
Bupivacaine Approved, Investigational Phase 4,Phase 3 38396-39-3, 2180-92-9 2474
21
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
22
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
23
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
24
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1 54-31-9 3440
25
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3 58-93-5 3639
26
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
27
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
28
Ezetimibe Approved Phase 4 163222-33-1 150311
29
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
30
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
31
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
33
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 46835353 6436030 5284616
34
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
35
Colchicine Approved Phase 4,Phase 2 64-86-8 2833 6167
36
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128794-94-5 5281078
37
Mycophenolic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 24280-93-1 446541
38
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
39 Taurolidine Approved, Investigational Phase 4,Phase 3 19388-87-5
40
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
42
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
43
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
44
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
45
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
46
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
47
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
48
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
49
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
50
Calcium acetate Approved, Investigational Phase 4,Phase 3 62-54-4

Interventional clinical trials:

(show top 50) (show all 1842)

# Name Status NCT ID Phase Drugs
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
2 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
3 Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
4 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
6 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Unknown status NCT01198379 Phase 4 aspirin;Placebo
9 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
10 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
11 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
12 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
13 Anesthetic Technique for AV Fistulae Creation Unknown status NCT01727557 Phase 4
14 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
15 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
16 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
17 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
18 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
19 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
20 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
21 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
22 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4 Spironolactone (drug)
23 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
24 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4 N-acetylcysteine
25 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
26 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
27 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
28 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
29 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
30 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
31 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
32 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
33 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
34 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
35 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
36 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4 Hydrochlorothiazide and furosemide
37 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
38 Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin. Unknown status NCT00404599 Phase 4 atrorvastatin 10mg;simvastatin 40mg
39 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
40 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
41 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
42 Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease Completed NCT01974817 Phase 4
43 Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5 Completed NCT02392208 Phase 4 Telavancin
44 Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure Completed NCT00124969 Phase 4 Amlodipine;Placebo
45 Parathyroidectomy in Endstage Renal Disease Completed NCT00745719 Phase 4
46 Surveillance Study to Estimate the Incidence of Pure Red Blood Cell Aplasia Among Patients With Chronic Kidney Failure Completed NCT00391287 Phase 4
47 Evaluating Aranesp® for the Treatment of Anemia in African-American Subjects With Chronic Renal Failure (CRF) Receiving Hemodialysis Completed NCT00111995 Phase 4 Aranesp®
48 Interferon Treatment for Patients With Chronic Hepatitis C and End Stage Renal Disease Completed NCT00172809 Phase 4 Peginterferon alfa-2a;Interferon alfa-2a
49 EPO-BUL-01 - Study of the Optimization of Anemia Management of EPREX (Epoetin Alfa) in Predialysis Patients With Chronic Renal Failure Completed NCT00338000 Phase 4 Epoetin alfa
50 Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study Completed NCT01951404 Phase 4 Allopurinol;Placebo (for allopurinol)

Search NIH Clinical Center for End Stage Renal Failure

Inferred drug relations via UMLS 69 / NDF-RT 47 :
Sources

Genetic Tests for End Stage Renal Failure

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Genetic tests related to End Stage Renal Failure:

# Genetic test Affiliating Genes
1 Stage 5 Chronic Kidney Disease 28
Sources

Anatomical Context for End Stage Renal Failure

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MalaCards organs/tissues related to End Stage Renal Failure:

38
Kidney, Bone, Heart, Endothelial, Testes, Liver, Bone Marrow
Sources

Publications for End Stage Renal Failure

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Articles related to End Stage Renal Failure:

(show top 50) (show all 601)
# Title Authors Year
1
'Known unknowns - examining the burden of neurocognitive impairment in the end-stage renal failure population'. ( 29345092 )
2018
2
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
3
Peritonitis outcomes in patients with HIV and end-stage renal failure on peritoneal dialysis: a prospective cohort study. ( 28158991 )
2017
4
A pilot study of ultrasound evaluation of gastric emptying in patients with end-stage renal failure: a comparison with healthy controls. ( 28332186 )
2017
5
Acute thyroiditis: An under-recognized complication of parathyroidectomy in end-stage renal failure patients with secondary hyperparathyroidism. ( 28621009 )
2017
6
Cardiac Autonomic Neuropathy Predicts All-Cause and Cardiovascular Mortality in Patients With End-Stage Renal Failure: AA 5-Year Prospective Study. ( 29142986 )
2017
7
The effect of dialysis type on left atrial functions in patients with end-stage renal failure: A propensity score-matched analysis. ( 29226431 )
2017
8
End-stage renal failure due to transthyretin amyloidosis after liver transplantation: outcomes in 19 registry cases. ( 28434351 )
2017
9
Re: The Survival Benefit of Kidney Transplantation in the Setting of Combined Peripheral Arterial Disease and End-Stage Renal Failure. ( 28208552 )
2017
10
Trends in Lower Limb Revascularization Among Patients With End-Stage Renal Failure: Where Is the Journey Going, and How Far Have We Come? ( 29050630 )
2017
11
Sign and magnitude scaling properties of heart rate variability in patients with end-stage renal failure: Are these properties useful to identify pathophysiological adaptations? ( 28964157 )
2017
12
Importance of RIFLE (Risk, Injury, Failure, Loss, and End-Stage Renal Failure) and AKIN (Acute Kidney Injury Network) in Hemodialysis Initiation and Intensive Care Unit Mortality. ( 28761207 )
2017
13
Haploidentical hematopoietic bone marrow transplantation followed by living kidney transplantation from the same donor in a sickle cell disease patient with end-stage renal failure. ( 28160086 )
2017
14
Atrial Fibrillation and End Stage Renal Failure in Patients Receiving Dialysis: Balancing the Risks and Benefits of Stroke Prevention. ( 28457737 )
2017
15
Pharmacokinetics of dexmedetomidine administered to patients with end-stage renal failure and secondary hyperparathyroidism undergoing general anaesthesia. ( 29247451 )
2017
16
Reversal of end-stage renal failure using direct-acting antiviral agents for chronic hepatitis C. ( 27581262 )
2016
17
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure. ( 27090781 )
2016
18
Ocular Surface Disorders in a Group of Egyptian Children with End Stage Renal Failure on Dialysis: A Cross-Sectional Study. ( 26942000 )
2016
19
Mineral and bone disorders, morbidity and mortality in end-stage renal failure patients on chronic dialysis. ( 27004031 )
2016
20
Fever with intradialytic pelvic pain: a case of iliopsoas abscess complicated with Methicillin-sensitive Staphylococcus Aureus bacteraemia in an end stage renal failure patient. ( 27326946 )
2016
21
Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping. ( 27503805 )
2016
22
Comparison of clinical and laboratory parameters in patients with end-stage renal failure in the outcome of chronic glomerulonephritis and patients with end-stage renal failure in the outcome of other diseases. ( 28214807 )
2016
23
CONTINUOUS AMBULATORY PERITONEAL DIALYSIS IN PATIENTS WITH HIV AND END-STAGE RENAL FAILURE. ( 27935535 )
2016
24
Prevalence and Risk Factors of Lower Limb Amputation in Patients with End-Stage Renal Failure on Dialysis: A Systematic Review. ( 27529033 )
2016
25
Metastatic pulmonary calcification in end-stage renal failure. ( 27486208 )
2016
26
Impact of HCV Infection on Diabetes Patients for the Risk of End-Stage Renal Failure. ( 26817874 )
2016
27
Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective. ( 27277135 )
2016
28
Unusual cause of hypercalcaemia in end stage renal failure patients. ( 27866377 )
2016
29
Emergency cardiac double valve surgery in active infective endocarditis due to Acinetobacter baumannii with aortic root abscess in a patient with dialysis-dependent end-stage renal failure: a rare case report. ( 27915239 )
2016
30
Role of Procalcitonin in Differential Diagnosis of Pneumonia and Pulmonary Congestion Associated With End-Stage Renal Failure. ( 27805517 )
2016
31
Angioplasty of forearm arteries as a finger salvage procedure for patient with end-stage renal failure. ( 27143949 )
2016
32
The survival benefit of kidney transplantation in the setting of combined peripheral arterial disease and end-stage renal failure. ( 26914805 )
2016
33
Effects of hemodialysis on macular and retinal nerve fiber layer thicknesses in non-diabetic patients with end stage renal failure. ( 27279510 )
2016
34
Crystalline cardiomyopathy due to secondary oxalosis after short-bowel syndrome and end-stage renal failure. ( 27008641 )
2016
35
Nocturnal blood pressure non-dipping is not associated with increased left ventricular mass index in hypertensive children without end-stage renal failure. ( 27344339 )
2016
36
Rupture of an infectious pseudoaneurysm of the aortic arch in an end-stage renal failure patient with chronic hemodialysis. ( 26042414 )
2015
37
Low Infection Rates in Total Knee Arthroplasty in End Stage Renal Failure Patients. ( 26282498 )
2015
38
Baroreflex activation therapy in patients with end-stage renal failure: proof of concept. ( 26335429 )
2015
39
Intravenous ceftaroline 200 mg administered every 8 h is safe and adequate for meticillin-resistant Staphylococcus aureus bloodstream infections in end-stage renal failure patients on haemodialysis: a case study. ( 26607339 )
2015
40
Palliative care for a mentally incompetent end stage renal failure patient: why is it important? ( 25838954 )
2015
41
Sequential molecularly targeted drug therapy including axitinib for a patient with end-stage renal failure and metastatic renal cell carcinoma. ( 26306562 )
2015
42
Role of renin-angiotensin system inhibitors in retardation of progression of end-stage renal failure: a retrospective study. ( 26519376 )
2015
43
Penile lesion in end-stage renal failure - cancer or otherwise?: Calcific uremic arteriolopathy presenting with a penile lesion. ( 26085872 )
2015
44
Pharmacokinetics and pharmacodynamics of pegloticase in patients with end-stage renal failure receiving hemodialysis. ( 25816806 )
2015
45
Calcific uraemic arteriolopathy in a patient with end-stage renal failure and chronic plaque psoriasis: could TNF-I+ inhibition help ameliorate disease progression? ( 25688703 )
2015
46
Predictor of cardiovascular risks in end stage renal failure patients on maintenance dialysis. ( 26870086 )
2015
47
Causes of end stage renal failure among haemodialysis patients in Khartoum State/Sudan. ( 26419536 )
2015
48
The Association between Human Leukocyte Antigens and Hypertensive End-Stage Renal Failure among Yemeni Patients. ( 26052458 )
2015
49
Aetiology of Paediatric End-stage Renal Failure in Jordan: A Multicentre Study. ( 26684161 )
2015
50
Use of Erythropoietin-Stimulating Agents (ESA) in Patients With End-Stage Renal Failure Decided to Forego Dialysis: Palliative Perspective. ( 26718957 )
2015
Sources

Variations for End Stage Renal Failure

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Sources

Expression for End Stage Renal Failure

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Search GEO for disease gene expression data for End Stage Renal Failure.
Sources

Pathways for End Stage Renal Failure

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Pathways related to End Stage Renal Failure according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Selenium Micronutrient Network 1
Show member pathways
 12.19 ALB CRP IL6 TNF
2
Dilated cardiomyopathy (DCM) 36
Show member pathways
 12.06 ACE IL6 TGFB1 TNF
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 61
11.9 ALB IL6 TGFB1 WT1
4
Adipogenesis 1
11.88 AGT IL6 TGFB1 TNF
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 61
11.8 CD79A EPO IL6 TNF
6
IL-6 signaling pathway 1
Show member pathways
 11.7 AGT CRP IL6
7
ACE Inhibitor Pathway, Pharmacodynamics 57
Show member pathways
 11.66 ACE AGT TGFB1
8
AGE-RAGE signaling pathway in diabetic complications 36
11.66 COL4A5 IL6 TGFB1 TNF
9
Dendritic Cells Developmental Lineage Pathway 61
11.61 IL6 TGFB1 TNF
10
Amoebiasis 36
11.6 COL4A5 IL6 TGFB1 TNF
11
IgA-Producing B Cells in the Intestine 61
11.54 IL6 TGFB1 TNF
12
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 61
11.54 CD79A IL6 PTH TGFB1
13
Lung fibrosis 1
11.51 IL6 TGFB1 TNF
14
Malaria 36
11.38 IL6 TGFB1 TNF
15
Transcription_Role of VDR in regulation of genes involved in osteoporosis 21
11.32 IL6 PTH TNF
16
Cytokines and Inflammatory Response 1
11.06 IL6 TGFB1 TNF
17
Primary Focal Segmental Glomerulosclerosis FSGS 1
10.97 COL4A5 MYH9 NPHS1 NPHS2 TGFB1 WT1
18
Differentiation Pathway 1
10.94 EPO IL6 TF TGFB1
19
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
10.66 IL6 TGFB1
20
Overview of nanoparticle effects 1
10.61 CRP IL6 TNF
Sources

GO Terms for End Stage Renal Failure

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Cellular components related to End Stage Renal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ACE AGT ALB CRP CST3 EPO
2 blood microparticle GO:0072562 9.62 AGT ALB TF TGFB1
3 endoplasmic reticulum lumen GO:0005788 9.55 ALB COL4A5 CST3 IL6 TF
4 extracellular region GO:0005576 9.44 ACE AGT ALB COL4A5 CRP CST3
5 slit diaphragm GO:0036057 9.37 NPHS1 NPHS2
6 extracellular exosome GO:0070062 10 ACE AGT ALB CRP CST3 MYH9

Biological processes related to End Stage Renal Failure according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.88 ALB CST3 IL6 TF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 AGT IL6 TGFB1 TNF
3 regulation of receptor activity GO:0010469 9.8 AGT EPO IL6 PTH TGFB1 TNF
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 AGT IL6 TGFB1
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 IL6 TGFB1 TNF
6 negative regulation of fat cell differentiation GO:0045599 9.71 IL6 TGFB1 TNF
7 kidney development GO:0001822 9.67 ACE AGT PKD1 WT1
8 excretion GO:0007588 9.63 NPHS1 NPHS2 UMOD
9 acute-phase response GO:0006953 9.61 CRP EPO IL6
10 angiotensin maturation GO:0002003 9.6 ACE AGT
11 neutrophil mediated immunity GO:0002446 9.58 ACE IL6
12 response to salt stress GO:0009651 9.57 EPO TNF
13 glomerular basement membrane development GO:0032836 9.56 NPHS1 WT1
14 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.55 ACE AGT
15 metanephric ascending thin limb development GO:0072218 9.49 PKD1 UMOD
16 negative regulation of extracellular matrix disassembly GO:0010716 9.48 CST3 TGFB1
17 positive regulation of mononuclear cell migration GO:0071677 9.4 TGFB1 TNF
18 regulation of renal output by angiotensin GO:0002019 9.26 ACE AGT
19 mononuclear cell proliferation GO:0032943 9.16 ACE TGFB1
20 positive regulation of superoxide anion generation GO:0032930 9.13 AGT CRP TGFB1
21 negative regulation of lipid storage GO:0010888 8.8 CRP IL6 TNF
22 positive regulation of transcription, DNA-templated GO:0045893 10 AGT EPO IL6 TGFB1 TNF WT1

Molecular functions related to End Stage Renal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 EPO IL6 TGFB1 TNF
Sources

Sources for End Stage Renal Failure

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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