MCID: END030
MIFTS: 58

End Stage Renal Failure malady

Nephrological diseases category
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Summaries for End Stage Renal Failure

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Wikipedia:65 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

MalaCards based summary: End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to peritonitis and hyperparathyroidism. An important gene associated with End Stage Renal Failure is EPO (erythropoietin), and among its related pathways are Aldosterone-regulated sodium reabsorption and IL-9 Signaling Pathways. The compounds doxazosin and polysulfone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related mouse phenotypes are adipose tissue and liver/biliary system.

Aliases & Classifications for End Stage Renal Failure

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End Stage Renal Failure, Aliases & Descriptions:

Name: End Stage Renal Failure 30 8 10
Chronic Kidney Disease Stage 5 62
 
End Stage Renal Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:783
ICD1025 N18.5

Related Diseases for End Stage Renal Failure

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Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 360)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.6SLPI, SELP
2hyperparathyroidism31.1EPO, SLPI
3primary hyperoxaluria31.1EPO, RETN, ACE, SLPI
4diabetic nephropathy31.0INS, EPO, ACE
5erythrocytosis30.8EPO, ACE
6cerebrovascular disease30.8ACE, SELP
7peripheral vascular disease30.8SELP, ACE
8hypothyroidism30.7LEP, LEPQTL1, RETN
9vascular disease30.7INS, SELP, RETN, ACE
10polycythemia vera30.6SELP, EPO
11obstructive sleep apnea30.5LEPQTL1, LEP
12proteinuria30.5ACE, LEPQTL1, INS
13acute myocardial infarction30.5ACE, RETN, SELP
14familial partial lipodystrophy30.5LEP, INS
15hypertension30.4IGF1, INS, LEP, RETN, ACE
16sickle cell disease30.3EPO, SELP
17liver cirrhosis30.2LEP, LEPQTL1, RETN, SLPI
18essential hypertension30.2INS, LEP, SELP, RETN, ACE
19myocardial infarction30.2LEPQTL1, SELP, RETN, ACE
20diabetic retinopathy30.1ACE, INS, IGF1
21lipodystrophy30.0RETN, LEPQTL1, LEP, INS
22uremia29.9IGF1, LEP, LEPQTL1, EPO, RETN
23obesity29.5IGF1, INS, LEP, LEPQTL1, RETN
24diabetes mellitus29.5IGF1, INS, LEP, LEPQTL1, SELP, RETN
25type 1 diabetes mellitus29.4IGF1, INS, LEP, LEPQTL1, RETN, ACE
26insulin resistance29.3IGF1, INS, LEP, LEPQTL1, RETN, ACE
27atherosclerosis29.3IGF1, INS, LEP, LEPQTL1, SELP, RETN
28type 2 diabetes mellitus29.1IGF1, INS, LEP, LEPQTL1, SELP, RETN
29hyperphosphatemia10.7
30amyloidosis10.6
31kidney disease10.6
32lupus nephritis10.6
33glomerulonephritis10.6
34hepatitis10.6
35arteriovenous fistula10.5
36tuberculosis10.5
37endotheliitis10.5
38systemic lupus erythematosus10.5
39lupus erythematosus10.5
40nephrogenic systemic fibrosis10.5
41calciphylaxis10.5
42malignant hypertension10.5
43myeloma10.5
44medullary cystic kidney disease type 110.5
45umod-associated kidney disease10.5
46hypoxia10.5
47ischemia10.5
48nephrotic syndrome10.5
49periodontitis10.5
50critical limb ischemia10.4

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to end stage renal failure

Symptoms for End Stage Renal Failure

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Drugs & Therapeutics for End Stage Renal Failure

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Drug clinical trials:

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Search NIH Clinical Center for End Stage Renal Failure

Genetic Tests for End Stage Renal Failure

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Anatomical Context for End Stage Renal Failure

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MalaCards organs/tissues related to End Stage Renal Failure:

32
Kidney, Heart, Bone, Liver, Pancreas, T cells, Endothelial, Testes, Bone marrow, Lung, Thyroid, Neutrophil, Skeletal muscle, Breast, Skin, Myeloid, Monocytes, Pituitary

Animal Models for End Stage Renal Failure or affiliated genes

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MGI Mouse Phenotypes related to End Stage Renal Failure:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6IGF1, INS, LEP, RETN, ACE
2MP:00053708.6ACE, RETN, EPO, SELP, LEP, INS
3MP:00107718.4IGF1, INS, LEP, SELP, EPO
4MP:00053898.4NPHP4, ACE, LEP, INS, IGF1
5MP:00053678.3IGF1, INS, LEP, SELP, ACE, NPHP4
6MP:00053858.0IGF1, INS, LEP, SELP, EPO, ACE
7MP:00053847.8IGF1, INS, LEP, SELP, EPO, ACE
8MP:00053977.4IGF1, INS, LEP, SELP, EPO, ACE
9MP:00107687.3IGF1, INS, LEP, SELP, EPO, ACE
10MP:00053877.3IGF1, INS, LEP, SELP, ACE, SLPI
11MP:00053767.2IGF1, INS, LEP, SELP, EPO, RETN

Publications for End Stage Renal Failure

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Articles related to End Stage Renal Failure:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Varicella encephalitis and pneumonia in a patient with end stage renal failure. (24555522)
2014
2
Clinical Outcomes After Infrainguinal Bypass Grafting for Critical Limb Ischaemia in Patients with Dialysis-dependent End-stage Renal Failure. (25281532)
2014
3
Cardiac device-related endocarditis in the patient with end-stage renal failure in the course of Fabry disease. (23813154)
2013
4
Safety and efficacy of vemurafenib in end stage renal failure. (24314265)
2013
5
Colorectal complications of end-stage renal failure and renal transplantation: a review. (22493792)
2012
6
Motor disability in end-stage renal failure: an epidemiological study on Italian dialyzed patients. (22089791)
2011
7
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
8
Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration. (20368400)
2010
9
End stage renal failure mimicking as acute renal failure in developing countries. (20058588)
2009
10
Open heart surgery in patients with end-stage renal failure: fifteen-year experience. (18778299)
2009
11
Aristolochic acid nephropathy due to herbal drug intake manifested differently as Fanconi's syndrome and end-stage renal failure--a 7-year follow-up. (19049714)
2008
12
Successful use of cinacalcet HCl in a patient with end-stage renal failure and refractory secondary hyperparathyroidism due to parathyromatosis. (17390744)
2007
13
No evidence for advanced glycation endproducts in cancer. Comment on SebekovA! et al: genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute? (Kidney Blood Press Res 2007;30:56-66). (17700031)
2007
14
Sense of humor and survival among a county cohort of patients with end-stage renal failure: a two-year prospective study. (17236695)
2006
15
Effect of different hemodialysis regimens on genomic damage in end-stage renal failure. (16412822)
2006
16
Interleukin 1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism in patients with end-stage renal failure. (15717635)
2005
17
Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis. (15658577)
2004
18
The red blood cell deformability in patients suffering from end stage renal failure on hemodialysis or continuous ambulatory peritoneal dialysis. (15287203)
2004
19
Counselling should be offered to people with end-stage renal failure. (15163032)
2004
20
End-stage renal failure and management of diabetes. (15088931)
2004
21
Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis. (12914790)
2003
22
Vitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure. (11774111)
2002
23
Inflammation in end-stage renal failure: could it be treated? (12147775)
2002
24
Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. (11213072)
2001
25
Cystatin C in a rat model of end-stage renal failure. (11499558)
2001
26
Association of serum nitric oxide levels with depressive symptoms: a study with end-stage renal failure patients. (11408841)
2001
27
A retrospective survey of attitudes toward acceptance of peritoneal dialysis in Chinese end-stage renal failure patients in Hong Kong--from a cultural point of view. (11887844)
2001
28
Hemodiafiltration for vancomycin overdose in a patient with end-stage renal failure. (11793092)
2001
29
Arterial wave reflections and survival in end-stage renal failure. (11566918)
2001
30
Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)
1999
31
Clinical course after total parathyroidectomy without autotransplantation in patients with end-stage renal failure. (10023643)
1999
32
Polymorphisms in the genes encoding for human kinin receptors and the risk of end-stage renal failure: results of transmission/disequilibrium test. The End-Stage Renal Disease Study Group. (10505688)
1999
33
Brown tumor as manifestation of parathyroid hyperplasia in two cases with end-stage renal failure. (10050098)
1999
34
The genetics of renal tumors in end-stage renal failure differs from those occurring in the general population. (9621287)
1998
35
Genitourinary tuberculosis as the cause of unexplained hypercalcaemia in a patient with pre-end-stage renal failure. (9509470)
1998
36
The successful outcome of pregnancy in a woman with end-stage renal failure chronically hemodialyzed without change of treatment regimen. (9434081)
1997
37
Townes-Brocks syndrome presenting as end stage renal failure. (9072124)
1997
38
Geographical variation in the referral of patients with chronic end stage renal failure for renal replacement therapy. (8729557)
1996
39
End-stage renal failure due to diabetic nephropathy in Spain. (8700368)
1996
40
Pharmacokinetics of meloxicam in patients with end-stage renal failure on haemodialysis: a comparison with healthy volunteers. (9010704)
1996
41
Is there still a role for a diet very low in protein, with or without supplements, in the management of patients with end-stage renal failure? (8823540)
1996
42
Carbamylated hemoglobin: a potential marker for the adequacy of hemodialysis therapy in end-stage renal failure. (8887297)
1996
43
Accumulation of glycated albumin in end-stage renal failure: evidence for the principle of "physiological microalbuminuria". (8712223)
1996
44
Deranged platelet calcium homeostasis in diabetic patients with end-stage renal failure. A possible link to increased cardiovascular mortality? (8886550)
1996
45
Nephroblastoma and end-stage renal failure with bilateral cystic kidneys. (7794714)
1995
46
Effects of erythropoietin therapy on the lipid profile in end-stage renal failure. (8196294)
1994
47
Hematologic aspects of end-stage renal failure. (8061105)
1994
48
Benefits and costs of recombinant human erythropoietin for end-stage renal failure: a review. Benefits and costs of erythropoietin. (8288425)
1993
49
Interrelationships among the renin-angiotensin system, sympathetic nervous system and atrial natriuretic peptide in end-stage renal failure. (2141372)
1990
50
Malignant hypertension in end-stage renal failure: hemodynamic and hormone status. (3913571)
1985

Variations for End Stage Renal Failure

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Expression for genes affiliated with End Stage Renal Failure

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Expression patterns in normal tissues for genes affiliated with End Stage Renal Failure

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Pathways for genes affiliated with End Stage Renal Failure

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Pathways related to End Stage Renal Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5INS, IGF1
2
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.3RETN, LEP, INS
39.2IGF1, INS, EPO
48.8RETN, LEP, INS, IGF1
5
Show member pathways
8.7IGF1, INS, LEP, ACE
6
Show member pathways
8.7ACE, LEP, INS, IGF1

Compounds for genes affiliated with End Stage Renal Failure

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Compounds related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1doxazosin44 1110.7INS, SELP, ACE
2polysulfone449.6EPO, SELP, LEPQTL1
3telmisartan44 28 1111.6INS, LEP, ACE
4sibutramine44 1110.5LEPQTL1, LEP, INS
5thiazolidinedione449.5INS, LEP, RETN
6beta-hydroxybutyrate449.4LEPQTL1, LEP, INS
7intralipid449.4LEPQTL1, LEP, INS
8fenofibrate44 50 1111.4INS, LEP, SELP, RETN
9cortisone44 2410.4LEP, INS, IGF1
10orlistat44 61 1111.3INS, LEP, LEPQTL1
118-isoprostane449.3RETN, LEP, INS
12budesonide44 50 1111.3LEP, LEPQTL1, SELP
13losartan44 50 28 1112.3IGF1, LEP, SELP, ACE
14nash449.2INS, LEP, LEPQTL1, RETN
15pravastatin44 50 28 24 1113.2LEP, LEPQTL1, SELP, ACE
16octreotide44 61 28 1112.1EPO, LEPQTL1, INS, IGF1
17aicar44 24 1111.1LEP, INS, IGF1
18rosiglitazone28 44 50 24 1113.1RETN, LEPQTL1, LEP, INS
19carbohydrates449.0INS, LEP, LEPQTL1, SELP
20acipimox44 2810.0LEPQTL1, LEP, INS, IGF1
21dehydroepiandrosterone sulfate449.0LEPQTL1, LEP, INS, IGF1
22androstenedione44 249.9LEPQTL1, LEP, INS, IGF1
23aprotinin44 119.9IGF1, SELP, EPO, SLPI
24urea44 24 1110.8LEPQTL1, EPO, RETN, SLPI
25deoxypyridinoline448.8SLPI, LEPQTL1, IGF1
26raloxifene44 50 28 1111.7IGF1, LEPQTL1, AOX1, SLPI
27dhea448.7IGF1, INS, LEP, LEPQTL1, RETN
28gnrh448.7IGF1, INS, LEP, LEPQTL1, EPO
29thyroxine44 249.7IGF1, INS, LEP, LEPQTL1, RETN
30ly294002448.6IGF1, INS, LEP, SELP, EPO, RETN
31acth448.5IGF1, INS, LEP, LEPQTL1
3225-hydroxyvitamin d448.4SLPI, LEP, IGF1
33uric acid44 249.4INS, LEP, LEPQTL1, RETN, SLPI
34metformin44 50 1110.4IGF1, ACE, RETN, LEPQTL1, LEP, INS
35aspartate448.4SLPI, RETN, EPO, SELP, LEPQTL1
36phosphatidylinositol448.3IGF1, INS, LEP, LEPQTL1, EPO, RETN
37hydrocortisone44 2 61 1111.3IGF1, INS, LEPQTL1, EPO, SLPI
38lactate448.3INS, LEPQTL1, SELP, EPO, SLPI
39tamoxifen44 50 28 1111.3IGF1, LEP, LEPQTL1, AOX1, SLPI
40estradiol44 24 1110.2IGF1, LEP, LEPQTL1, RETN, SLPI
41fibrinogen448.1INS, LEP, LEPQTL1, SELP, RETN, SLPI
42c-peptide447.9RETN, LEPQTL1, LEP, INS, IGF1, SLPI
43vegf447.7IGF1, LEP, LEPQTL1, SELP, EPO, RETN
44testosterone44 61 24 1110.6IGF1, INS, LEP, LEPQTL1, EPO, RETN
45dexamethasone44 50 28 1110.5IGF1, INS, LEP, LEPQTL1, SELP, RETN
46estrogen447.5IGF1, INS, LEP, LEPQTL1, SELP, RETN
47norepinephrine44 24 119.5INS, LEP, LEPQTL1, SELP, RETN, ACE
48glucose447.2IGF1, INS, LEP, LEPQTL1, RETN, ACE
49cholesterol44 28 24 1110.2IGF1, INS, LEP, LEPQTL1, SELP, RETN
50creatinine447.0SLPI, IGF1, INS, LEP, LEPQTL1, SELP

GO Terms for genes affiliated with End Stage Renal Failure

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Cellular components related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ACE, EPO, LEP, INS, IGF1
2extracellular spaceGO:0056156.9ACE, IGF1, INS, LEP, HILPDA, SELP

Biological processes related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.0LEP, SELP
2negative regulation of feeding behaviorGO:200025210.0INS, RETN
3positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
4positive regulation of smooth muscle cell migrationGO:0149119.9RETN, IGF1
5positive regulation of Ras protein signal transductionGO:0465799.9EPO, IGF1
6bone mineralization involved in bone maturationGO:0356309.8IGF1, LEP
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8EPO, IGF1
8response to insulinGO:0328689.8RETN, LEP
9positive regulation of glycolytic processGO:0458219.7IGF1, INS
10positive regulation of glycogen biosynthetic processGO:0457259.7IGF1, INS
11positive regulation of glucose importGO:0463269.6INS, IGF1
12positive regulation of cytokine productionGO:0018199.6LEP, HILPDA
13positive regulation of DNA replicationGO:0457409.6IGF1, INS, EPO
14blood vessel remodelingGO:0019749.5IGF1, ACE
15positive regulation of mitosisGO:0458409.5INS, IGF1
16positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5SELP, INS, IGF1
17positive regulation of MAPK cascadeGO:0434109.4LEP, INS, IGF1
18positive regulation of smooth muscle cell proliferationGO:0486619.4RETN, IGF1
19positive regulation of cell proliferationGO:0082848.5EPO, HILPDA, LEP, INS, IGF1

Molecular functions related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.4INS, IGF1
2insulin receptor bindingGO:0051589.2IGF1, INS
3hormone activityGO:0051798.5RETN, EPO, LEP, INS, IGF1
4protein bindingGO:0055156.7SLPI, NPHP4, ACE, EPO, SELP, HILPDA

Products for genes affiliated with End Stage Renal Failure

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Sources for End Stage Renal Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet