End Stage Renal Failure disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for End Stage Renal Failure

Sources:
⁶⁴Wikipedia, ³²MalaCards
See all sources

Wikipedia:⁶⁴ Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

MalaCards based summary: End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to peritonitis and hyperparathyroidism. An important gene associated with End Stage Renal Failure is EPO (erythropoietin), and among its related pathways are Aldosterone-regulated sodium reabsorption and IL-9 Signaling Pathways. The compounds doxazosin and polysulfone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related mouse phenotypes are adipose tissue and liver/biliary system.

Aliases & Classifications for End Stage Renal Failure

Sources:
³¹LifeMap Discovery®, ⁹Disease Ontology, ¹¹DISEASES, ⁶¹UMLS, ²⁶ICD10
See all sources

End Stage Renal Failure, Aliases & Descriptions:

Name: End Stage Renal Failure ³¹ ⁹ ¹¹

Chronic Kidney Disease Stage 5 ⁶¹

End Stage Renal Disease ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases

ICD10: ²⁶

Diseases of the genitourinary system

Renal failure

Chronic kidney disease

Chronic kidney disease, stage 5

External Ids:

Disease Ontology⁹ DOID:783

ICD10²⁶ N18.5

UMLS⁶¹ C1261469

Related Diseases for End Stage Renal Failure

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 360)

id	Related Disease	Score	Top Affiliating Genes
1	peritonitis	31.6	SLPI, SELP
2	hyperparathyroidism	31.1	SLPI, EPO
3	primary hyperoxaluria	31.1	EPO, SLPI, ACE, RETN
4	diabetic nephropathy	31.0	INS, EPO, ACE
5	erythrocytosis	30.8	ACE, EPO
6	cerebrovascular disease	30.8	ACE, SELP
7	peripheral vascular disease	30.8	SELP, ACE
8	hypothyroidism	30.7	LEPQTL1, RETN, LEP
9	vascular disease	30.7	RETN, INS, SELP, ACE
10	polycythemia vera	30.6	EPO, SELP
11	obstructive sleep apnea	30.5	LEPQTL1, LEP
12	proteinuria	30.5	INS, LEPQTL1, ACE
13	acute myocardial infarction	30.5	RETN, ACE, SELP
14	familial partial lipodystrophy	30.5	LEP, INS
15	hypertension	30.4	ACE, RETN, IGF1, LEP, INS
16	sickle cell disease	30.3	SELP, EPO
17	liver cirrhosis	30.2	RETN, LEP, LEPQTL1, SLPI
18	essential hypertension	30.2	SELP, ACE, LEP, INS, RETN
19	myocardial infarction	30.2	RETN, SELP, LEPQTL1, ACE
20	diabetic retinopathy	30.1	ACE, IGF1, INS
21	lipodystrophy	30.0	RETN, INS, LEP, LEPQTL1
22	uremia	29.9	EPO, RETN, LEP, IGF1, LEPQTL1
23	obesity	29.5	IGF1, LEPQTL1, LEP, RETN, INS
24	diabetes mellitus	29.5	LEP, SELP, RETN, ACE, LEPQTL1, INS
25	type 1 diabetes mellitus	29.4	RETN, LEP, LEPQTL1, ACE, INS, IGF1
26	insulin resistance	29.3	ACE, LEPQTL1, LEP, INS, IGF1, RETN
27	atherosclerosis	29.3	INS, IGF1, ACE, RETN, LEPQTL1, LEP
28	type 2 diabetes mellitus	29.1	SELP, IGF1, RETN, ACE, INS, LEP
29	hyperphosphatemia	10.7
30	amyloidosis	10.6
31	kidney disease	10.6
32	lupus nephritis	10.6
33	glomerulonephritis	10.6
34	hepatitis	10.6
35	arteriovenous fistula	10.5
36	tuberculosis	10.5
37	endotheliitis	10.5
38	systemic lupus erythematosus	10.5
39	lupus erythematosus	10.5
40	nephrogenic systemic fibrosis	10.5
41	calciphylaxis	10.5
42	malignant hypertension	10.5
43	myeloma	10.5
44	medullary cystic kidney disease type 1	10.5
45	umod-associated kidney disease	10.5
46	hypoxia	10.5
47	ischemia	10.5
48	nephrotic syndrome	10.5
49	periodontitis	10.5
50	critical limb ischemia	10.4

Graphical network of the top 20 diseases related to End Stage Renal Failure:

Symptoms for End Stage Renal Failure

Drugs & Therapeutics for End Stage Renal Failure

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for End Stage Renal Failure

Search NIH Clinical Center for End Stage Renal Failure

Genetic Tests for End Stage Renal Failure

Anatomical Context for End Stage Renal Failure

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to End Stage Renal Failure:

³²

Kidney, Heart, Bone, Liver, Pancreas, T cells, Endothelial, Testes, Bone marrow, Lung, Thyroid, Neutrophil, Skeletal muscle, Breast, Skin, Myeloid, Monocytes, Pituitary

Animal Models for End Stage Renal Failure or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to End Stage Renal Failure:

³⁶ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	adipose tissue phenotype	MP:0005375	8.6	IGF1, INS, LEP, RETN, ACE
2	liver/biliary system phenotype	MP:0005370	8.6	ACE, RETN, EPO, SELP, LEP, INS
3	integument phenotype	MP:0010771	8.4	IGF1, INS, LEP, SELP, EPO
4	reproductive system phenotype	MP:0005389	8.4	NPHP4, ACE, LEP, INS, IGF1
5	renal/urinary system phenotype	MP:0005367	8.3	IGF1, INS, LEP, SELP, ACE, NPHP4
6	cardiovascular system phenotype	MP:0005385	8.0	IGF1, INS, LEP, SELP, EPO, ACE
7	cellular phenotype	MP:0005384	7.8	IGF1, INS, LEP, SELP, EPO, ACE
8	hematopoietic system phenotype	MP:0005397	7.4	IGF1, INS, LEP, SELP, EPO, ACE
9	mortality/aging	MP:0010768	7.3	IGF1, INS, LEP, SELP, EPO, ACE
10	immune system phenotype	MP:0005387	7.3	IGF1, INS, LEP, SELP, ACE, SLPI
11	homeostasis/metabolism phenotype	MP:0005376	7.2	IGF1, INS, LEP, SELP, EPO, RETN

Publications for End Stage Renal Failure

Sources:
⁵¹PubMed
See all sources

Articles related to End Stage Renal Failure:

(show top 50) (show all 543)

id	Title	Authors	Year
1	Varicella encephalitis and pneumonia in a patient with end stage renal failure. (24555522)	Low L.L.... Suhail S.M.	2014
2	Clinical Outcomes After Infrainguinal Bypass Grafting for Critical Limb Ischaemia in Patients with Dialysis-dependent End-stage Renal Failure. (25281532)	Kodama A.... Komori K.	2014
3	Cardiac device-related endocarditis in the patient with end-stage renal failure in the course of Fabry disease. (23813154)	Tomaszuk-Kazberuk A.... Malyszko J.	2013
4	Safety and efficacy of vemurafenib in end stage renal failure. (24314265)	Iddawela M.... Adam W.R.	2013
5	Colorectal complications of end-stage renal failure and renal transplantation: a review. (22493792)	Parnaby C.N.... Watson A.J.	2012
6	Motor disability in end-stage renal failure: an epidemiological study on Italian dialyzed patients. (22089791)	Vischini G.... Palumbo R.	2011
7	Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)	Dickerson E.... Tabor E.	2010
8	Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration. (20368400)	Hafner V.... Haefeli W.E.	2010
9	End stage renal failure mimicking as acute renal failure in developing countries. (20058588)	Lal C.... Tiwari S.C.	2009
10	Open heart surgery in patients with end-stage renal failure: fifteen-year experience. (18778299)	Bahar I.... Birincioglu L.	2009
11	Aristolochic acid nephropathy due to herbal drug intake manifested differently as Fanconi's syndrome and end-stage renal failure--a 7-year follow-up. (19049714)	Kong P.I.... Chen H.C.	2008
12	Successful use of cinacalcet HCl in a patient with end-stage renal failure and refractory secondary hyperparathyroidism due to parathyromatosis. (17390744)	Unbehaun R.... Lauerwald W.	2007
13	No evidence for advanced glycation endproducts in cancer. Comment on SebekovA! et al: genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute? (Kidney Blood Press Res 2007;30:56-66). (17700031)	Buetler T.	2007
14	Sense of humor and survival among a county cohort of patients with end-stage renal failure: a two-year prospective study. (17236695)	Svebak S.... d K.	2006
15	Effect of different hemodialysis regimens on genomic damage in end-stage renal failure. (16412822)	Schupp N.... Heidland A.	2006
16	Interleukin 1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism in patients with end-stage renal failure. (15717635)	Shu K.H.... Lee W.C.	2005
17	Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis. (15658577)	Nasri H.... Baradaran A.	2004
18	The red blood cell deformability in patients suffering from end stage renal failure on hemodialysis or continuous ambulatory peritoneal dialysis. (15287203)	Sotirakopoulos N.... Mavromatidis K.	2004
19	Counselling should be offered to people with end-stage renal failure. (15163032)	Kelly M.... Tibbles R.	2004
20	End-stage renal failure and management of diabetes. (15088931)	Bilous R.W.	2004
21	Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis. (12914790)	Moser B.... Ankersmit H.J.	2003
22	Vitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure. (11774111)	Tsuruoka S.... Fujimura A.	2002
23	Inflammation in end-stage renal failure: could it be treated? (12147775)	Stenvinkel P.	2002
24	Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. (11213072)	Molmenti E.P.... Fung J.J.	2001
25	Cystatin C in a rat model of end-stage renal failure. (11499558)	BAPkenkamp A.... Dieterich C.	2001
26	Association of serum nitric oxide levels with depressive symptoms: a study with end-stage renal failure patients. (11408841)	Papageorgiou C.... Christodoulou G.N.	2001
27	A retrospective survey of attitudes toward acceptance of peritoneal dialysis in Chinese end-stage renal failure patients in Hong Kong--from a cultural point of view. (11887844)	Lo W.K.... Lui S.L.	2001
28	Hemodiafiltration for vancomycin overdose in a patient with end-stage renal failure. (11793092)	Akil I.O.... Mir S.	2001
29	Arterial wave reflections and survival in end-stage renal failure. (11566918)	London G.M.... Safar M.E.	2001
30	Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)	De Lima J.J.... Krieger E.M.	1999
31	Clinical course after total parathyroidectomy without autotransplantation in patients with end-stage renal failure. (10023643)	Stracke S.... Keller F.	1999
32	Polymorphisms in the genes encoding for human kinin receptors and the risk of end-stage renal failure: results of transmission/disequilibrium test. The End-Stage Renal Disease Study Group. (10505688)	Zychma M.J.... Grzeszczak W.	1999
33	Brown tumor as manifestation of parathyroid hyperplasia in two cases with end-stage renal failure. (10050098)	Apaydin S.... UlkA1 U.	1999
34	The genetics of renal tumors in end-stage renal failure differs from those occurring in the general population. (9621287)	Chudek J.... Kovacs G.	1998
35	Genitourinary tuberculosis as the cause of unexplained hypercalcaemia in a patient with pre-end-stage renal failure. (9509470)	Peces R.... Gago E.	1998
36	The successful outcome of pregnancy in a woman with end-stage renal failure chronically hemodialyzed without change of treatment regimen. (9434081)	Krawczyk W.... RA^zyc P.	1997
37	Townes-Brocks syndrome presenting as end stage renal failure. (9072124)	Newman W.G.... Donnai D.	1997
38	Geographical variation in the referral of patients with chronic end stage renal failure for renal replacement therapy. (8729557)	Boyle P.J.... Williams A.J.	1996
39	End-stage renal failure due to diabetic nephropathy in Spain. (8700368)	Robles N.R.... SA!nchez-Casado E.	1996
40	Pharmacokinetics of meloxicam in patients with end-stage renal failure on haemodialysis: a comparison with healthy volunteers. (9010704)	TA1rck D.... Heinzel G.	1996
41	Is there still a role for a diet very low in protein, with or without supplements, in the management of patients with end-stage renal failure? (8823540)	Klahr S.	1996
42	Carbamylated hemoglobin: a potential marker for the adequacy of hemodialysis therapy in end-stage renal failure. (8887297)	Davenport A.... Feest T.G.	1996
43	Accumulation of glycated albumin in end-stage renal failure: evidence for the principle of "physiological microalbuminuria". (8712223)	Donnelly S.M.	1996
44	Deranged platelet calcium homeostasis in diabetic patients with end-stage renal failure. A possible link to increased cardiovascular mortality? (8886550)	Vicari A.M.... Folli F.	1996
45	Nephroblastoma and end-stage renal failure with bilateral cystic kidneys. (7794714)	Craver R.D.... Warrier R.P.	1995
46	Effects of erythropoietin therapy on the lipid profile in end-stage renal failure. (8196294)	Pollock C.A.... George C.R.	1994
47	Hematologic aspects of end-stage renal failure. (8061105)	ZachAce P.... Boogaerts M.A.	1994
48	Benefits and costs of recombinant human erythropoietin for end-stage renal failure: a review. Benefits and costs of erythropoietin. (8288425)	McNamee P.... Segaar R.	1993
49	Interrelationships among the renin-angiotensin system, sympathetic nervous system and atrial natriuretic peptide in end-stage renal failure. (2141372)	Nakajima S.... Saruta T.	1990
50	Malignant hypertension in end-stage renal failure: hemodynamic and hormone status. (3913571)	Schohn D.C.... Jahn H.A.	1985

Genes related to End Stage Renal Failure

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to End Stage Renal Failure:

(show all 12)

- Elite gene

id	Symbol	Description	Score	Implication
1	EPO	erythropoietin	20.89	GeneCards inferred via : Publications (show sections)
2	AOX1	aldehyde oxidase 1	19.22	GeneCards inferred via : Publications (show sections)
3	RETN	resistin	17.55	GeneCards inferred via : Publications (show sections)
4	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	15.89	GeneCards inferred via : Publications (show sections)
5	ACE	angiotensin I converting enzyme	14.22	GeneCards inferred via : Publications (show sections)
6	NPHP4	nephronophthisis 4	12.55	GeneCards inferred via : Disorders (show sections)
7	LEP	leptin	10.89	GeneCards inferred via : Publications (show sections)
8	INS	insulin	9.22	GeneCards inferred via : Publications (show sections)
9	IGF1	insulin-like growth factor 1 (somatomedin C)	7.55	GeneCards inferred via : Publications (show sections)
10	HILPDA	hypoxia inducible lipid droplet-associated	5.89	GeneCards inferred via : Publications (show sections)
11	SLPI	secretory leukocyte peptidase inhibitor	4.22	GeneCards inferred via : Publications (show sections)
12	LEPQTL1	Leptin, serum levels of	1.69	GeneCards inferred via : Publications (show sections)

Products for genes related to End Stage Renal Failure disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	10	-	11	11
2	Novus Biologicals	9	9	11	-

Variations for End Stage Renal Failure

Expression for genes affiliated with End Stage Renal Failure

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for genes affiliated with End Stage Renal Failure

Sources:
⁴⁹PathCards, ³⁰KEGG, ⁵³R&D Systems, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters, ⁵²QIAGEN, ⁵⁴Reactome
See all sources

Pathways related to End Stage Renal Failure according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Aldosterone-regulated sodium reabsorption³⁰	9.5	INS, IGF1
2	IL-9 Signaling Pathways⁵³ Show member pathways IL-21 Signaling Pathways⁵³ IL-9 Signaling Pathway³⁷ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways⁵³ Development Thrombopoietin regulated cell processes⁵⁹ IL-15 Signaling Pathways⁵³ IL-7 Signaling Pathways⁵³ Adipocytokines and Insulin Signaling⁵³ IL-7 Signaling Pathway³⁷ IL-2 Signaling Pathways⁵³ Immune response IL 9 signaling pathway⁵⁹ IL-4 Signaling Pathways⁵³ IL-9 Pathway⁵²	9.3	RETN, LEP, INS
3	HIF-1 signaling pathway³⁰	9.2	IGF1, INS, EPO
4	Adipogenesis³⁷	8.8	RETN, LEP, INS, IGF1
5	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein⁵⁴ Show member pathways Synthesis of Dolichyl-phosphate⁵⁴ Asparagine N-linked glycosylation⁵⁴ ER Quality Control Compartment (ERQC)⁵⁴ N-glycan trimming and elongation in the cis-Golgi⁵⁴ Synthesis of GDP-mannose⁵⁴ N-glycan antennae elongation in the medial/trans-Golgi⁵⁴ Synthesis of UDP-N-acetyl-glucosamine⁵⁴ GDP-mannose biosynthesis³⁷ N-Glycan biosynthesis³⁰ Reactions specific to the hybrid N-glycan synthesis pathway⁵⁴ Reactions specific to the complex N-glycan synthesis pathway⁵⁴ Synthesis of dolichyl-phosphate-glucose⁵⁴ Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2⁵⁴ Transport to the Golgi and subsequent modification⁵⁴ Calnexin/calreticulin cycle⁵⁴ Metabolism of proteins⁵⁴ dolichol and dolichyl phosphate biosynthesis³⁷ N-Glycan antennae elongation⁵⁴ N-glycan trimming in the ER and Calnexin/Calreticulin cycle⁵⁴ Post-translational protein modification⁵⁴ Synthesis of substrates in N-glycan biosythesis⁵⁴ dolichyl-diphosphooligosaccharide biosynthesis³⁷ D-mannose degradation³⁷ Synthesis of dolichyl-phosphate mannose⁵⁴	8.7	IGF1, INS, LEP, ACE
6	Peptide hormone metabolism⁵⁴ Show member pathways Glycoprotein hormones⁵⁴ thyroid hormone biosynthesis³⁷ Insulin Processing⁵⁴ Metabolism of Angiotensinogen to Angiotensins⁵⁴ Synthesis, Secretion, and Deacylation of Ghrelin⁵⁴ Peptide hormone biosynthesis⁵⁴	8.7	ACE, LEP, INS, IGF1

Compounds for genes affiliated with End Stage Renal Failure

Sources:
⁴⁴Novoseek, ¹²DrugBank, ²⁹IUPHAR, ⁵⁰PharmGKB, ²⁵HMDB, ⁶⁰Tocris Bioscience, ³BitterDB
See all sources

Compounds related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show top 50) (show all 139)

id	Compound	Score	Top Affiliating Genes
1	doxazosin⁴⁴ ¹²	10.7	SELP, ACE, INS
2	polysulfone⁴⁴	9.6	SELP, EPO, LEPQTL1
3	telmisartan⁴⁴ ²⁹ ¹²	11.6	ACE, INS, LEP
4	sibutramine⁴⁴ ¹²	10.5	LEP, LEPQTL1, INS
5	thiazolidinedione⁴⁴	9.5	LEP, INS, RETN
6	beta-hydroxybutyrate⁴⁴	9.4	INS, LEP, LEPQTL1
7	intralipid⁴⁴	9.4	LEP, LEPQTL1, INS
8	fenofibrate⁴⁴ ⁵⁰ ¹²	11.4	INS, LEP, RETN, SELP
9	cortisone⁴⁴ ²⁵	10.4	INS, IGF1, LEP
10	orlistat⁴⁴ ⁶⁰ ¹²	11.3	LEPQTL1, LEP, INS
11	8-isoprostane⁴⁴	9.3	LEP, INS, RETN
12	budesonide⁴⁴ ⁵⁰ ¹²	11.3	SELP, LEPQTL1, LEP
13	losartan⁴⁴ ⁵⁰ ²⁹ ¹²	12.3	LEP, IGF1, ACE, SELP
14	nash⁴⁴	9.2	LEPQTL1, RETN, LEP, INS
15	pravastatin⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.2	LEP, SELP, ACE, LEPQTL1
16	octreotide⁴⁴ ⁶⁰ ²⁹ ¹²	12.1	EPO, LEPQTL1, IGF1, INS
17	aicar⁴⁴ ²⁵ ¹²	11.1	LEP, IGF1, INS
18	rosiglitazone²⁹ ⁴⁴ ⁵⁰ ²⁵ ¹²	13.1	LEP, INS, RETN, LEPQTL1
19	carbohydrates⁴⁴	9.0	INS, LEP, LEPQTL1, SELP
20	acipimox⁴⁴ ²⁹	10.0	LEP, LEPQTL1, INS, IGF1
21	dehydroepiandrosterone sulfate⁴⁴	9.0	LEPQTL1, INS, IGF1, LEP
22	androstenedione⁴⁴ ²⁵	9.9	LEPQTL1, IGF1, INS, LEP
23	aprotinin⁴⁴ ¹²	9.9	EPO, IGF1, SLPI, SELP
24	urea⁴⁴ ²⁵ ¹²	10.8	RETN, EPO, LEPQTL1, SLPI
25	deoxypyridinoline⁴⁴	8.8	LEPQTL1, IGF1, SLPI
26	raloxifene⁴⁴ ⁵⁰ ²⁹ ¹²	11.7	SLPI, AOX1, LEPQTL1, IGF1
27	dhea⁴⁴	8.7	LEPQTL1, RETN, IGF1, INS, LEP
28	gnrh⁴⁴	8.7	IGF1, INS, LEP, LEPQTL1, EPO
29	thyroxine⁴⁴ ²⁵	9.7	RETN, LEPQTL1, LEP, INS, IGF1
30	ly294002⁴⁴	8.6	LEP, EPO, RETN, SELP, INS, IGF1
31	acth⁴⁴	8.5	LEPQTL1, LEP, INS, IGF1
32	25-hydroxyvitamin d⁴⁴	8.4	IGF1, SLPI, LEP
33	uric acid⁴⁴ ²⁵	9.4	INS, LEP, LEPQTL1, RETN, SLPI
34	metformin⁴⁴ ⁵⁰ ¹²	10.4	INS, LEP, IGF1, RETN, ACE, LEPQTL1
35	aspartate⁴⁴	8.4	SELP, EPO, RETN, SLPI, LEPQTL1
36	phosphatidylinositol⁴⁴	8.3	IGF1, INS, EPO, LEP, LEPQTL1, RETN
37	hydrocortisone⁴⁴ ³ ⁶⁰ ¹²	11.3	IGF1, SLPI, EPO, LEPQTL1, INS
38	lactate⁴⁴	8.3	EPO, SELP, LEPQTL1, INS, SLPI
39	tamoxifen⁴⁴ ⁵⁰ ²⁹ ¹²	11.3	SLPI, LEP, LEPQTL1, AOX1, IGF1
40	estradiol⁴⁴ ²⁵ ¹²	10.2	LEP, LEPQTL1, RETN, SLPI, IGF1
41	fibrinogen⁴⁴	8.1	RETN, LEPQTL1, SLPI, LEP, INS, SELP
42	c-peptide⁴⁴	7.9	IGF1, INS, LEP, LEPQTL1, RETN, SLPI
43	vegf⁴⁴	7.7	IGF1, SLPI, LEP, LEPQTL1, SELP, EPO
44	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	10.6	INS, LEP, SLPI, LEPQTL1, EPO, RETN
45	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.5	SLPI, RETN, SELP, LEPQTL1, LEP, INS
46	estrogen⁴⁴	7.5	RETN, IGF1, INS, SLPI, SELP, LEPQTL1
47	norepinephrine⁴⁴ ²⁵ ¹²	9.5	RETN, AOX1, ACE, INS, LEP, SELP
48	glucose⁴⁴	7.2	LEP, SLPI, AOX1, ACE, RETN, LEPQTL1
49	cholesterol⁴⁴ ²⁹ ²⁵ ¹²	10.2	LEPQTL1, LEP, RETN, ACE, SLPI, INS
50	creatinine⁴⁴	7.0	LEP, RETN, EPO, SELP, LEPQTL1, SLPI

GO Terms for genes affiliated with End Stage Renal Failure

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to End Stage Renal Failure according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	8.5	IGF1, INS, LEP, EPO, ACE
2	extracellular space	GO:005615	6.9	IGF1, INS, LEP, HILPDA, SELP, EPO

Biological processes related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte tethering or rolling	GO:050901	10.0	SELP, LEP
2	negative regulation of feeding behavior	GO:2000252	10.0	INS, RETN
3	positive regulation of insulin receptor signaling pathway	GO:046628	9.9	INS, LEP
4	positive regulation of smooth muscle cell migration	GO:014911	9.9	IGF1, RETN
5	positive regulation of Ras protein signal transduction	GO:046579	9.9	EPO, IGF1
6	bone mineralization involved in bone maturation	GO:035630	9.8	IGF1, LEP
7	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.8	EPO, IGF1
8	response to insulin	GO:032868	9.8	LEP, RETN
9	positive regulation of glycolytic process	GO:045821	9.7	IGF1, INS
10	positive regulation of glycogen biosynthetic process	GO:045725	9.7	IGF1, INS
11	positive regulation of glucose import	GO:046326	9.6	INS, IGF1
12	positive regulation of cytokine production	GO:001819	9.6	HILPDA, LEP
13	positive regulation of DNA replication	GO:045740	9.6	EPO, INS, IGF1
14	blood vessel remodeling	GO:001974	9.5	ACE, IGF1
15	positive regulation of mitosis	GO:045840	9.5	INS, IGF1
16	positive regulation of phosphatidylinositol 3-kinase signaling	GO:014068	9.5	INS, SELP, IGF1
17	positive regulation of MAPK cascade	GO:043410	9.4	IGF1, INS, LEP
18	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	IGF1, RETN
19	positive regulation of cell proliferation	GO:008284	8.5	HILPDA, IGF1, INS, LEP, EPO

Molecular functions related to End Stage Renal Failure according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor receptor binding	GO:005159	9.4	INS, IGF1
2	insulin receptor binding	GO:005158	9.2	INS, IGF1
3	hormone activity	GO:005179	8.5	IGF1, RETN, EPO, LEP, INS
4	protein binding	GO:005515	6.7	SLPI, NPHP4, ACE, EPO, SELP, HILPDA

Products for genes affiliated with End Stage Renal Failure

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Sources for End Stage Renal Failure

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: END030 MIFTS: 57	End Stage Renal Failure malady Nephrological diseases category
12 genes, 18 tissues, 360 related diseases, clinical trials Download this MalaCard Expand all tables

End Stage Renal Failure malady