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MCID: END030
MIFTS: 52

End Stage Renal Failure malady

Nephrological diseases category
71 genes, 17 tissues, 332 related diseases, clinical trials.

Summaries for End Stage Renal Failure

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

MalaCards: End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to peritonitis and hypertension. An important gene associated with End Stage Renal Failure is PKD1 (polycystic kidney disease 1 (autosomal dominant)). The compounds estrogen and uric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for End Stage Renal Failure

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases
ICD10: 25


Aliases & Descriptions:

end stage renal failure 8 10
chronic kidney disease stage 5 60
end stage renal disease 8


External Ids:

Disease Ontology8 DOID:783
ICD1025 N18.5

Related Diseases for End Stage Renal Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 332)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.3SELPLG, SLPI
2hypertension31.0CD79A, RETN, PTH
3primary hyperoxaluria30.9GAST, PKD1, CD79A, EPO, PTH
4diabetic nephropathy30.9EPO, CNDP1, AGTR2, UMOD
5peptic ulcer30.8GAST
6vascular disease30.7SELPLG
7hyperparathyroidism30.7GAST, MEN1, EPO, SLPI, PTH
8diabetes mellitus30.7LSL, UMOD, CNDP1, CD79A, RETN, PTH
9tuberculosis30.7LSL, CD79A
10nephrotic syndrome30.6LAMB2, CD79A
11ischemia30.6BDKRB1, AGTR2, SELPLG
12chronic kidney failure30.6PTH, BDKRB1, LSL, UMOD, MEN1, PKD1
13type 2 diabetes mellitus30.5SLPI, RETN, AGTR2, LSL
14thyroiditis30.5CD79A
15renal osteodystrophy30.5PTH, SLPI
16nephronophthisis30.5XPNPEP3
17myeloma30.5UMOD, CD79A, EPO
18hypothyroidism30.5PTH, RETN, LSL
19proteinuria30.5CD79A, AGTR2, UMOD, LSL
20pyelonephritis30.5CD79A, UMOD
21atherosclerosis30.5LSL, AGTR2, RETN, SELPLG
22polycystic kidney disease30.4UMOD, PKD1, EPO
23uremia30.4LSL, MEN1, EPO, RETN, PTH
24viral hepatitis30.2SLPI
25liver cirrhosis30.2SLPI, RETN, LSL
26chronic pyelonephritis30.2UMOD
27obesity30.2RETN, LSL
28hypercalcemia30.2GAST, MEN1, SLPI, PTH
29breast cancer30.2MEN1, AGTR2, PKD1, PTH
30leukemia30.2MEN1, CD79A, EPO, SLPI, SELPLG
31cystic kidney30.2UMOD, PKD1
32gout30.2UMOD
33von hippel-lindau disease30.2MEN1, PKD1
34acute myocardial infarction30.2RETN
35esophagitis30.2GAST
36myocardial infarction30.2LSL, AGTR2, RETN, SELPLG
37renal hypertension10.7
38hyperphosphatemia10.7
39amyloidosis10.6
40kidney disease10.6
41systemic lupus erythematosus10.5
42lupus erythematosus10.5
43hepatitis10.5
44arteriovenous fistula10.5
45renal tuberculosis10.5
46glomerulonephritis10.5
47renal vascular disease10.5
48periodontal disease10.4
49periodontitis10.4
50calciphylaxis10.4

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to end stage renal failure

Clinical Features for End Stage Renal Failure

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Drugs & Therapeutics for End Stage Renal Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for End Stage Renal Failure

Drug clinical trials:

Search ClinicalTrials for End Stage Renal Failure

Search NIH Clinical Center for End Stage Renal Failure

Search CenterWatch for End Stage Renal Failure

Genetic Tests for End Stage Renal Failure

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Anatomical Context for End Stage Renal Failure

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32MalaCards
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MalaCards organs/tissues related to End Stage Renal Failure:

32
Kidney, Heart, Bone, Liver, Pancreas, T cells, Endothelial, Testes, Bone marrow, Thyroid, Lung, Breast, Myeloid, Monocytes, Skin, Pituitary, Skeletal muscle

Animal Models for End Stage Renal Failure or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to End Stage Renal Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
renal/urinary system phenotype
MP:000536710.2UMOD, AGTR2, PKD1, CD79A, LAMB2, SELPLG
2
homeostasis/metabolism phenotype
MP:00053769.8SELPLG, BDKRB1, UMOD, GAST, MEN1, AGTR2
3
immune system phenotype
MP:00053879.7MEN1, GAST, UMOD, BDKRB1, PKD1, CD79A

Publications for End Stage Renal Failure

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Sources:
50PubMed
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Articles related to End Stage Renal Failure:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Colorectal complications of end-stage renal failure and renal transplantation: a review. (22493792)
2012
2
Eculizumab for patients with paroxysmal nocturnal hemoglobinuria (PNH) is effective during the maintenance of hemodialysis for end stage renal failure. (21145109)
2011
3
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
4
Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration. (20368400)
2010
5
Ivabradine as a heart rate-lowering agent in a patient with end-stage renal failure after heart transplantation. (20806202)
2010
6
Impact of duration of hemodialysis on gastrointestinal symptoms in patients with end stage renal failure. (21188344)
2010
7
An experience of pancreas and islet transplantation in patients with end stage renal failure due to diabetes type I. (19337154)
2009
8
Use of ketamine for ischemic pain in end-stage renal failure. (18201864)
2008
9
Multicentre, parallel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal function. (18653492)
2008
10
Changes in osmolal gap and osmolality in children with chronic and end-stage renal failure. (17139190)
2007
11
Interleukin-6 gene polymorphism and faster progression to end-stage renal failure in chronic glomerulonephritis. (17656329)
2007
12
Predictors of renal recovery in Australian and New Zealand end-stage renal failure patients treated with peritoneal dialysis. (17299156)
2007
13
Fluid dynamics of gingiva and gingival health in children with end stage renal failure. (17719557)
2007
14
Statins and cardiovascular risk reduction in patients with chronic kidney disease and end-stage renal failure. (17383281)
2007
15
Sense of humor and survival among a county cohort of patients with end-stage renal failure: a two-year prospective study. (17236695)
2006
16
Peritoneal clearance of biochemical markers of bone turnover in children with end stage renal failure on peritoneal dialysis. (16848114)
2006
17
Interleukin 1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism in patients with end-stage renal failure. (15717635)
2005
18
In end-stage renal failure, does infection lead to elevated plasma aluminium and neurotoxicity? Implications for monitoring. (15829127)
2005
19
Effects of handgrip training and intermittent compression of upper arm veins on forearm vessels in patients with end-stage renal failure. (15966998)
2005
20
On-line hemodiafiltration as routine treatment of end-stage renal failure: why pre- or mixed dilution mode is necessary in on-line hemodiafiltration today? (15655323)
2004
21
Quantitative ultrasound at hand phalanges in adults with end-stage renal failure. (15121247)
2004
22
Early initiation of dialysis fails to prolong survival in patients with end-stage renal failure. (15031369)
2004
23
Atherosclerosis in patients with end-stage renal failure prior to initiation of hemodialysis. (12739831)
2003
24
Increased delivery of haemodialysis assists successful pregnancy outcome in end-stage renal failure. (15012702)
2003
25
End-stage renal failure patients requiring renal replacement therapy in the intensive care unit: incidence, clinical features, and outcome. (12601260)
2003
26
End-stage renal failure in a child with X-linked ichthyosis. (12644929)
2003
27
New-onset seizures as an initial presentation of end-stage renal failure in patients with HIV/AIDS. (12138881)
2002
28
Cidofovir-induced end-stage renal failure. (11773481)
2002
29
Liver resection for hepatocellular carcinoma in patients with end-stage renal failure. (11745817)
2001
30
Glomerulonephritis after methicillin-resistant Staphylococcus aureus infection resulting in end-stage renal failure. (11393416)
2001
31
Cardiac troponin T and I in end-stage renal failure. (10973864)
2000
32
Prevalence of sleep disturbances in chinese patients with end-stage renal failure on continuous ambulatory peritoneal dialysis. (11007681)
2000
33
Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure. (10648668)
2000
34
Increased intracellular reactive oxygen species in patients with end-stage renal failure: effect of hemodialysis. (10916112)
2000
35
Reversible acute renal failure due to acute interstitial nephritis in a patient with end-stage liver disease. (11096320)
2000
36
Comparing different methods of assessing body composition in end-stage renal failure. (10886589)
2000
37
Hemodiafiltration for vancomycin overdose in a neonate with end-stage renal failure. (10412863)
1999
38
Postoperative rhabdomyolysis in patients with end-stage renal failure. (9506695)
1998
39
Plasma adrenomedullin levels, body fluid status, and end-stage renal failure. (9736827)
1998
40
End stage renal failure and assessment of health related quality of life. (10339019)
1998
41
Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure. (9555662)
1998
42
Smoking as a risk factor for end-stage renal failure in men with primary renal disease. (9734618)
1998
43
Is HCV-infection another reason to opt for peritoneal dialysis in end-stage renal failure? (9226242)
1997
44
What's new in the delivery of care in end-stage renal failure? (9375262)
1997
45
Effect of renal transplantation on pulmonary function in patients with end-stage renal failure. (8919231)
1996
46
Nephroblastoma and end-stage renal failure with bilateral cystic kidneys. (7794714)
1995
47
Effects of oral calcitriol on bone mineral density in patients with end-stage renal failure. (8127015)
1994
48
Non-cardiac benefits of human recombinant erythropoietin in end stage renal failure and anaemia. (8257180)
1993
49
Aortic and mitral valve disease in patients with end stage renal failure on long-term haemodialysis. (1554541)
1992
50
Pseudohermaphroditism, glomerulopathy, and Wilms tumor (Drash syndrome): frequency in end-stage renal failure. (2984395)
1985

Genetic Variations for End Stage Renal Failure

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Expression for genes affiliated with End Stage Renal Failure

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for genes affiliated with End Stage Renal Failure

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Compounds for genes affiliated with End Stage Renal Failure

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CD79A
2uric acid44 2411.7SLPI, UMOD
3deoxypyridinoline4410.7PTH, LSL
4captopril44 28 49 59 1114.7CD79A, AGTR2, BDKRB1
5norepinephrine44 11 2412.6GAST, AGTR2, RETN, SLPI
6sialic acid4410.6LSL, UMOD, CD79A, EPO, SELPLG
7methacholine44 1111.6GAST, CD79A, SLPI
8urea44 11 2412.6LSL, UMOD, EPO, RETN, SLPI
9cycloheximide4410.6BDKRB1, PTH
10c-peptide4410.6LSL, GAST, RETN, SLPI
11carbachol44 28 1112.6GAST, CD79A, SLPI, PTH
12hydrocortisone44 2 59 1113.6LSL, GAST, EPO, SLPI
13vitamin d4410.6GAST, MEN1, CD79A, EPO, SLPI, PTH
14vitamin b124410.6GAST, CD79A, EPO
15thyroxine44 2411.6LSL, GAST, CD79A, RETN, PTH
16octreotide44 59 28 1113.6EPO, GAST, LSL
17calcitriol44 59 11 2413.6GAST, EPO, SLPI, PTH
18fludrocortisone44 28 1112.6EPO, LSL
19sodium44 2411.6UMOD, AGTR2, PKD1, RETN, SLPI, PTH
20malondialdehyde4410.6SLPI, EPO, LSL
21fibrinogen4410.5LSL, CD79A, RETN, SLPI, SELPLG
22heparin44 28 11 2413.5LSL, UMOD, GAST, CD79A, SLPI, LAMB2
23thymidine44 2411.5GAST, MEN1, EPO, SLPI, PTH
24testosterone44 59 11 2413.5LSL, GAST, PKD1, CD79A, EPO, RETN
25vegf4410.5LSL, GAST, MEN1, CD79A, EPO, RETN
26alanine4410.5LSL, GAST, AGTR2, PKD1, CD79A, RETN
27dexamethasone44 49 28 1113.5LSL, GAST, CD79A, RETN, SLPI, PTH
28aprotinin44 1111.4PTH, SLPI, EPO
29ascorbic acid44 2411.4GAST, CD79A, EPO, SLPI
30creatinine4410.4PTH, LSL, UMOD, GAST, AGTR2, CD79A
31nitric oxide44 11 2412.4BDKRB1, LSL, AGTR2, RETN, SLPI, PTH
32pneumococcal4410.4PKD1, CD79A
33tyrosine4410.4BDKRB1, GAST, MEN1, AGTR2, PKD1, EPO
34oxygen44 2411.3LSL, AGTR2, EPO, RETN, SLPI, SELPLG
35calcium44 49 11 2413.3MEN1, GAST, UMOD, LSL, BDKRB1, AGTR2
36azathioprine44 49 2 1113.2SLPI, EPO, CD79A
37glucose4410.2LSL, UMOD, GAST, RETN, SLPI, PTH
38cholesterol44 28 11 2413.2SELPLG, SLPI, RETN, LSL, BDKRB1
39histamine44 28 2412.0GAST, CD79A, SLPI, SELPLG

GO Terms for genes affiliated with End Stage Renal Failure

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Sources:
16Gene Ontology
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Cellular components related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1PTH, SLPI, RETN, EPO, CNDP1, AGTR2

Biological processes related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metanephric ascending thin limb developmentGO:07221810.4PKD1, UMOD

Molecular functions related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3PTH, RETN, EPO, GAST

Products for genes affiliated with End Stage Renal Failure

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for End Stage Renal Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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