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MCID: END030
MIFTS: 40

End Stage Renal Failure malady

Nephrological category
71 genes, 2 tissues, 311 related diseases, clinical trials.

Summaries for End Stage Renal Failure

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Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

MalaCards: End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to primary hyperoxaluria and diabetic nephropathy. An important gene associated with End Stage Renal Failure is PKD1 (polycystic kidney disease 1 (autosomal dominant)). The compounds estrogen and uric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for End Stage Renal Failure

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological
ICD10: 25


Aliases & Descriptions:

end stage renal failure 8 10
chronic kidney disease stage 5 61
end stage renal disease 8


External Ids:

Disease Ontology8 DOID:783
ICD1025 N18.5

Related Diseases for End Stage Renal Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperoxaluria30.9PTH, GAST, CD79A, EPO, PKD1
2diabetic nephropathy30.9EPO, AGTR2, UMOD, CNDP1
3vascular disease30.7SELPLG
4tuberculosis30.7LSL, CD79A
5renal osteodystrophy30.5SLPI, PTH
6nephronophthisis30.5XPNPEP3
7atherosclerosis30.5SELPLG, RETN, LSL, AGTR2
8polycystic kidney disease30.5PKD1, UMOD, EPO
9uremia30.5RETN, EPO, MEN1, LSL, PTH
10viral hepatitis30.3SLPI
11multiple endocrine neoplasia30.3MEN1, GAST
12hypercalcemia30.3PTH, MEN1, SLPI, GAST
13gout30.2UMOD
14acute myocardial infarction30.2RETN
15hyperphosphatemia10.7
16hepatitis d10.7
17lupus nephritis10.6
18cardiovascular disease risk factor10.6
19amyloidosis10.6
20amyloidosis, renal10.6
21systemic lupus erythematosus10.6
22lip disease10.6
23nephrogenic systemic fibrosis10.5
24nutrition disease10.5
25renal tuberculosis10.5
26n syndrome10.5
27calciphylaxis10.4
28fabry disease10.4
29medullary cystic kidney disease type 110.4
30umod-associated kidney disease10.4
31hypoxia10.4
32nephritis10.4
33porphyria cutanea tarda10.4
34hepatitis e10.4
35arteriosclerosis10.4
36end-stage renal disease, nondiabetic, susceptibility to10.4
37m�ni�re disease10.4
38critical limb ischemia10.4
39alport syndrome10.3
40tuberous sclerosis10.3
41frasier syndrome10.3
42acute kidney failure10.3
43tuberous sclerosis complex10.3
44nephrotic syndrome, type 110.3
45hemoglobin d disease10.3
46epidural abscess10.3
47beta thalassemia10.3
48wegener's granulomatosis10.3
49arteriosclerosis obliterans10.3
50nephrolithiasis10.3

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to end stage renal failure

Clinical Features for End Stage Renal Failure

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Drugs & Therapeutics for End Stage Renal Failure

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for End Stage Renal Failure

Drug clinical trials:

Search ClinicalTrials for End Stage Renal Failure

Search NIH Clinical Center for End Stage Renal Failure

Search CenterWatch for End Stage Renal Failure

Genetic Tests for End Stage Renal Failure

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Anatomical Context for End Stage Renal Failure

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Sources:
33MalaCards
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MalaCards organs/tissues related to End Stage Renal Failure:

33
Kidney, Endothelial

Animal Models for End Stage Renal Failure or affiliated genes

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Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to End Stage Renal Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
renal/urinary system phenotype
MP:000536710.2UMOD, AGTR2, PKD1, CD79A, LAMB2, SELPLG
2
homeostasis/metabolism phenotype
MP:00053769.8SELPLG, BDKRB1, UMOD, GAST, MEN1, AGTR2
3
immune system phenotype
MP:00053879.7MEN1, GAST, UMOD, BDKRB1, PKD1, CD79A

Publications for End Stage Renal Failure

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Sources:
51PubMed
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Articles related to End Stage Renal Failure:

idTitleAuthorsYear
1
Cardiac device-related endocarditis in the patient with end-stage renal failure in the course of Fabry disease. (23813154)
2013
2
Predictive value of circulating endothelial microparticles for cardiovascular mortality in end-stage renal failure: a pilot study. (22036944)
2012
3
Single injection results of endoscopic treatment of vesicoureteric reflux with different tissue-bulking substances in patients with end stage renal failure. (21476901)
2011
4
No evidence for advanced glycation endproducts in cancer. Comment on SebekovA! et al: genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute? (Kidney Blood Press Res 2007;30:56-66). (17700031)
2007
5
Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. (16192427)
2005
6
Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure. (14732754)
2004
7
Multiple endocrine neoplasia type 1 in end-stage renal failure. (15619041)
2004
8
Effect of a hemodialysis session on plasma levels of endothelin-1 in hypertensive and normotensive subjects with end-stage renal failure. (9884416)
1999
9
Accumulation of the endogenous L-arginine analogue NG-monomethyl-L-arginine in human end-stage renal failure patients on regular haemodialysis. (8737080)
1996
10
Increased lymphocytic Na+/H+ exchange activity after hemodialysis: evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure. (8890935)
1996

Genetic Variations for End Stage Renal Failure

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Expression for genes affiliated with End Stage Renal Failure

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for genes affiliated with End Stage Renal Failure

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Compounds for genes affiliated with End Stage Renal Failure

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8CD79A
2uric acid45 2411.7UMOD, SLPI
3deoxypyridinoline4510.7PTH, LSL
4captopril45 29 50 60 1114.7CD79A, BDKRB1, AGTR2
5norepinephrine45 11 2412.6RETN, SLPI, AGTR2, GAST
6sialic acid4510.6UMOD, LSL, SELPLG, CD79A, EPO
7methacholine45 1111.6GAST, CD79A, SLPI
8urea45 11 2412.6RETN, EPO, UMOD, LSL, SLPI
9cycloheximide4510.6PTH, BDKRB1
10c-peptide4510.6GAST, SLPI, RETN, LSL
11carbachol45 29 1112.6PTH, SLPI, GAST, CD79A
12hydrocortisone45 2 60 1113.6LSL, GAST, EPO, SLPI
13vitamin d4510.6MEN1, PTH, SLPI, EPO, CD79A, GAST
14vitamin b124510.6EPO, GAST, CD79A
15thyroxine45 2411.6RETN, PTH, LSL, GAST, CD79A
16octreotide45 60 29 1113.6LSL, GAST, EPO
17calcitriol45 60 11 2413.6SLPI, EPO, GAST, PTH
18fludrocortisone45 29 1112.6LSL, EPO
19sodium45 2411.6PTH, SLPI, RETN, PKD1, AGTR2, UMOD
20malondialdehyde4510.6EPO, SLPI, LSL
21fibrinogen4510.5RETN, LSL, CD79A, SLPI, SELPLG
22heparin45 29 11 2413.5LSL, UMOD, GAST, CD79A, SLPI, LAMB2
23thymidine45 2411.5GAST, EPO, SLPI, PTH, MEN1
24testosterone45 60 11 2413.5CD79A, EPO, LSL, RETN, SLPI, PKD1
25vegf4510.5GAST, CD79A, PTH, SLPI, LSL, EPO
26alanine4510.5RETN, AGTR2, CD79A, PKD1, SLPI, SELPLG
27dexamethasone45 50 29 1113.5PTH, CD79A, GAST, SLPI, RETN, SELPLG
28aprotinin45 1111.4PTH, SLPI, EPO
29ascorbic acid45 2411.4EPO, SLPI, CD79A, GAST
30creatinine4510.4CD79A, LSL, UMOD, GAST, AGTR2, PTH
31nitric oxide45 11 2412.4AGTR2, PTH, RETN, SLPI, BDKRB1, LSL
32pneumococcal4510.4PKD1, CD79A
33tyrosine4510.4PKD1, SELPLG, AGTR2, PTH, SLPI, MEN1
34oxygen45 2411.3EPO, RETN, AGTR2, LSL, SELPLG, SLPI
35calcium45 50 11 2413.3RETN, SELPLG, PTH, SLPI, LSL, UMOD
36azathioprine45 50 2 1113.2SLPI, EPO, CD79A
37glucose4510.2SLPI, PTH, RETN, GAST, UMOD, LSL
38cholesterol45 29 11 2413.2RETN, SLPI, SELPLG, LSL, BDKRB1
39histamine45 29 2412.0SELPLG, SLPI, CD79A, GAST

GO Terms for genes affiliated with End Stage Renal Failure

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Sources:
16Gene Ontology
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Cellular components related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1PTH, SLPI, RETN, EPO, CNDP1, AGTR2

Biological processes related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metanephric ascending thin limb developmentGO:07221810.4PKD1, UMOD

Molecular functions related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3PTH, RETN, EPO, GAST

Products for genes affiliated with End Stage Renal Failure

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for End Stage Renal Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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