MCID: END030
MIFTS: 58

End Stage Renal Failure malady

Nephrological diseases category
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Summaries for End Stage Renal Failure

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65Wikipedia, 33MalaCards
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Wikipedia:65 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

MalaCards: End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to peritonitis and primary hyperoxaluria. An important gene associated with End Stage Renal Failure is EPO (erythropoietin), and among its related pathways are Aldosterone-regulated sodium reabsorption and IL-9 Signaling Pathways. The compounds doxazosin and polysulfone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related mouse phenotypes are adipose tissue and liver/biliary system.

Aliases & Classifications for End Stage Renal Failure

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8Disease Ontology, 10DISEASES, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

end stage renal failure 8 10
chronic kidney disease stage 5 62
end stage renal disease 8


External Ids:

Disease Ontology8 DOID:783
ICD1025 N18.5

Related Diseases for End Stage Renal Failure

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17GeneCards, 18GeneDecks
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Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 344)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.4SLPI, SELP
2primary hyperoxaluria31.0EPO, RETN, ACE, SLPI
3hypertension30.9IGF1, INS, LEP, RETN, ACE
4diabetic nephropathy30.9INS, EPO, ACE
5hyperparathyroidism30.8EPO, SLPI
6vascular disease30.7INS, SELP, RETN, ACE
7hypothyroidism30.6LEP, LEPQTL1, RETN
8cerebrovascular disease30.5ACE, SELP
9proteinuria30.5ACE, LEPQTL1, INS
10essential hypertension30.5INS, LEP, SELP, RETN, ACE
11diabetes mellitus30.5IGF1, INS, LEP, LEPQTL1, SELP, RETN
12erythrocytosis30.4EPO, ACE
13peripheral vascular disease30.4SELP, ACE
14polycythemia vera30.3SELP, EPO
15uremia30.3IGF1, LEP, LEPQTL1, EPO, RETN
16liver cirrhosis30.3LEP, LEPQTL1, RETN, SLPI
17obstructive sleep apnea30.3LEPQTL1, LEP
18coronary artery disease30.3ACE, RETN, SELP, INS
19acute myocardial infarction30.3ACE, RETN, SELP
20familial partial lipodystrophy30.3LEP, INS
21diabetic retinopathy30.3ACE, INS, IGF1
22sickle cell disease30.2EPO, SELP
23atherosclerosis30.2IGF1, INS, LEP, LEPQTL1, SELP, RETN
24type 2 diabetes mellitus30.2IGF1, INS, LEP, LEPQTL1, SELP, RETN
25myocardial infarction30.2LEPQTL1, SELP, RETN, ACE
26type 1 diabetes mellitus30.2IGF1, INS, LEP, LEPQTL1, RETN, ACE
27lipodystrophy30.2RETN, LEPQTL1, LEP, INS
28obesity30.1IGF1, INS, LEP, LEPQTL1, RETN
29insulin resistance30.1IGF1, INS, LEP, LEPQTL1, RETN, ACE
30hyperphosphatemia10.7
31amyloidosis10.6
32lupus nephritis10.6
33hepatitis10.6
34kidney disease10.6
35systemic lupus erythematosus10.5
36lupus erythematosus10.5
37arteriovenous fistula10.5
38glomerulonephritis10.5
39tuberculosis10.5
40nephrogenic systemic fibrosis10.5
41calciphylaxis10.5
42malignant hypertension10.5
43medullary cystic kidney disease type 110.5
44umod-associated kidney disease10.5
45nephritis10.5
46endotheliitis10.5
47ischemia10.4
48nephrotic syndrome10.4
49periodontitis10.4
50critical limb ischemia10.4

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to end stage renal failure

Symptoms for End Stage Renal Failure

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Drugs & Therapeutics for End Stage Renal Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for End Stage Renal Failure

Search NIH Clinical Center for End Stage Renal Failure

Genetic Tests for End Stage Renal Failure

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Anatomical Context for End Stage Renal Failure

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33MalaCards
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MalaCards organs/tissues related to End Stage Renal Failure:

33
Kidney, Heart, Bone, Liver, T cells, Pancreas, Endothelial, Testes, Bone marrow, Thyroid, Lung, Breast, Skin, Myeloid, Monocytes, Skeletal muscle, Pituitary

Animal Models for End Stage Renal Failure or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to End Stage Renal Failure:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6IGF1, INS, LEP, RETN, ACE
2MP:00053708.6ACE, RETN, EPO, SELP, LEP, INS
3MP:00107718.4IGF1, INS, LEP, SELP, EPO
4MP:00053898.4NPHP4, ACE, LEP, INS, IGF1
5MP:00053678.3IGF1, INS, LEP, SELP, ACE, NPHP4
6MP:00053858.0IGF1, INS, LEP, SELP, EPO, ACE
7MP:00053847.8IGF1, INS, LEP, SELP, EPO, ACE
8MP:00053977.4IGF1, INS, LEP, SELP, EPO, ACE
9MP:00107687.3IGF1, INS, LEP, SELP, EPO, ACE
10MP:00053877.3IGF1, INS, LEP, SELP, ACE, SLPI
11MP:00053767.2IGF1, INS, LEP, SELP, EPO, RETN

Publications for End Stage Renal Failure

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52PubMed
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Articles related to End Stage Renal Failure:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Cardiac device-related endocarditis in the patient with end-stage renal failure in the course of Fabry disease. (23813154)
2013
2
Safety and efficacy of vemurafenib in end stage renal failure. (24314265)
2013
3
Colorectal complications of end-stage renal failure and renal transplantation: a review. (22493792)
2012
4
Motor disability in end-stage renal failure: an epidemiological study on Italian dialyzed patients. (22089791)
2011
5
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
6
Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration. (20368400)
2010
7
End stage renal failure mimicking as acute renal failure in developing countries. (20058588)
2009
8
Open heart surgery in patients with end-stage renal failure: fifteen-year experience. (18778299)
2009
9
Aristolochic acid nephropathy due to herbal drug intake manifested differently as Fanconi's syndrome and end-stage renal failure--a 7-year follow-up. (19049714)
2008
10
Compositional and oxidative analysis in the saliva and serum of predialysis chronic kidney disease patients and end-stage renal failure patients on peritoneal dialysis. (18387167)
2008
11
Successful use of cinacalcet HCl in a patient with end-stage renal failure and refractory secondary hyperparathyroidism due to parathyromatosis. (17390744)
2007
12
No evidence for advanced glycation endproducts in cancer. Comment on SebekovA! et al: genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute? (Kidney Blood Press Res 2007;30:56-66). (17700031)
2007
13
Sense of humor and survival among a county cohort of patients with end-stage renal failure: a two-year prospective study. (17236695)
2006
14
Effect of different hemodialysis regimens on genomic damage in end-stage renal failure. (16412822)
2006
15
End-stage renal failure as a complication of acute tubulo-interstitial nephritis. (17642799)
2005
16
Interleukin 1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism in patients with end-stage renal failure. (15717635)
2005
17
Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis. (15658577)
2004
18
The red blood cell deformability in patients suffering from end stage renal failure on hemodialysis or continuous ambulatory peritoneal dialysis. (15287203)
2004
19
Counselling should be offered to people with end-stage renal failure. (15163032)
2004
20
End-stage renal failure and management of diabetes. (15088931)
2004
21
Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis. (12914790)
2003
22
Vitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure. (11774111)
2002
23
Inflammation in end-stage renal failure: could it be treated? (12147775)
2002
24
Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. (11213072)
2001
25
Cystatin C in a rat model of end-stage renal failure. (11499558)
2001
26
Association of serum nitric oxide levels with depressive symptoms: a study with end-stage renal failure patients. (11408841)
2001
27
A retrospective survey of attitudes toward acceptance of peritoneal dialysis in Chinese end-stage renal failure patients in Hong Kong--from a cultural point of view. (11887844)
2001
28
Hemodiafiltration for vancomycin overdose in a patient with end-stage renal failure. (11793092)
2001
29
Arterial wave reflections and survival in end-stage renal failure. (11566918)
2001
30
Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)
1999
31
Clinical course after total parathyroidectomy without autotransplantation in patients with end-stage renal failure. (10023643)
1999
32
Polymorphisms in the genes encoding for human kinin receptors and the risk of end-stage renal failure: results of transmission/disequilibrium test. The End-Stage Renal Disease Study Group. (10505688)
1999
33
Brown tumor as manifestation of parathyroid hyperplasia in two cases with end-stage renal failure. (10050098)
1999
34
The genetics of renal tumors in end-stage renal failure differs from those occurring in the general population. (9621287)
1998
35
Genitourinary tuberculosis as the cause of unexplained hypercalcaemia in a patient with pre-end-stage renal failure. (9509470)
1998
36
The successful outcome of pregnancy in a woman with end-stage renal failure chronically hemodialyzed without change of treatment regimen. (9434081)
1997
37
Townes-Brocks syndrome presenting as end stage renal failure. (9072124)
1997
38
Geographical variation in the referral of patients with chronic end stage renal failure for renal replacement therapy. (8729557)
1996
39
End-stage renal failure due to diabetic nephropathy in Spain. (8700368)
1996
40
Pharmacokinetics of meloxicam in patients with end-stage renal failure on haemodialysis: a comparison with healthy volunteers. (9010704)
1996
41
Is there still a role for a diet very low in protein, with or without supplements, in the management of patients with end-stage renal failure? (8823540)
1996
42
Carbamylated hemoglobin: a potential marker for the adequacy of hemodialysis therapy in end-stage renal failure. (8887297)
1996
43
Accumulation of glycated albumin in end-stage renal failure: evidence for the principle of "physiological microalbuminuria". (8712223)
1996
44
Deranged platelet calcium homeostasis in diabetic patients with end-stage renal failure. A possible link to increased cardiovascular mortality? (8886550)
1996
45
Nephroblastoma and end-stage renal failure with bilateral cystic kidneys. (7794714)
1995
46
Effects of erythropoietin therapy on the lipid profile in end-stage renal failure. (8196294)
1994
47
Hematologic aspects of end-stage renal failure. (8061105)
1994
48
Benefits and costs of recombinant human erythropoietin for end-stage renal failure: a review. Benefits and costs of erythropoietin. (8288425)
1993
49
Interrelationships among the renin-angiotensin system, sympathetic nervous system and atrial natriuretic peptide in end-stage renal failure. (2141372)
1990
50
Malignant hypertension in end-stage renal failure: hemodynamic and hormone status. (3913571)
1985

Variations for End Stage Renal Failure

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Expression for genes affiliated with End Stage Renal Failure

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for genes affiliated with End Stage Renal Failure

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50PathCards, 30KEGG, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome
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Pathways related to End Stage Renal Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5INS, IGF1
2
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.3RETN, LEP, INS
39.2IGF1, INS, EPO
48.8RETN, LEP, INS, IGF1
5
Show member pathways
8.7IGF1, INS, LEP, ACE
6
Show member pathways
8.7ACE, LEP, INS, IGF1

Compounds for genes affiliated with End Stage Renal Failure

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1doxazosin45 1110.7SELP, ACE, INS
2polysulfone459.6SELP, EPO, LEPQTL1
3telmisartan45 29 1111.6ACE, INS, LEP
4sibutramine45 1110.5LEP, LEPQTL1, INS
5thiazolidinedione459.5LEP, INS, RETN
6beta-hydroxybutyrate459.4INS, LEP, LEPQTL1
7intralipid459.4LEP, LEPQTL1, INS
8fenofibrate45 51 1111.4INS, LEP, RETN, SELP
9cortisone45 2410.4INS, IGF1, LEP
10orlistat45 61 1111.3LEPQTL1, LEP, INS
118-isoprostane459.3LEP, INS, RETN
12budesonide45 51 1111.3SELP, LEPQTL1, LEP
13losartan45 51 29 1112.3LEP, IGF1, ACE, SELP
14nash459.2LEPQTL1, RETN, LEP, INS
15pravastatin45 51 29 24 1113.2LEP, SELP, ACE, LEPQTL1
16octreotide45 61 29 1112.1EPO, LEPQTL1, IGF1, INS
17aicar45 24 1111.1LEP, IGF1, INS
18rosiglitazone29 45 51 24 1113.1LEP, INS, RETN, LEPQTL1
19carbohydrates459.0INS, LEP, LEPQTL1, SELP
20acipimox45 2910.0LEP, LEPQTL1, INS, IGF1
21dehydroepiandrosterone sulfate459.0LEPQTL1, INS, IGF1, LEP
22androstenedione45 249.9LEPQTL1, IGF1, INS, LEP
23aprotinin45 119.9EPO, IGF1, SLPI, SELP
24urea45 24 1110.8RETN, EPO, LEPQTL1, SLPI
25deoxypyridinoline458.8LEPQTL1, IGF1, SLPI
26raloxifene45 51 29 1111.7SLPI, AOX1, LEPQTL1, IGF1
27dhea458.7LEPQTL1, RETN, IGF1, INS, LEP
28gnrh458.7IGF1, INS, LEP, LEPQTL1, EPO
29thyroxine45 249.7RETN, LEPQTL1, LEP, INS, IGF1
30ly294002458.6LEP, EPO, RETN, SELP, INS, IGF1
31acth458.5LEPQTL1, LEP, INS, IGF1
3225-hydroxyvitamin d458.4IGF1, SLPI, LEP
33uric acid45 249.4INS, LEP, LEPQTL1, RETN, SLPI
34metformin45 51 1110.4INS, LEP, IGF1, RETN, ACE, LEPQTL1
35aspartate458.4SELP, EPO, RETN, SLPI, LEPQTL1
36phosphatidylinositol458.3IGF1, INS, EPO, LEP, LEPQTL1, RETN
37hydrocortisone45 3 61 1111.3IGF1, SLPI, EPO, LEPQTL1, INS
38lactate458.3EPO, SELP, LEPQTL1, INS, SLPI
39tamoxifen45 51 29 1111.3SLPI, LEP, LEPQTL1, AOX1, IGF1
40estradiol45 24 1110.2LEP, LEPQTL1, RETN, SLPI, IGF1
41fibrinogen458.1RETN, LEPQTL1, SLPI, LEP, INS, SELP
42c-peptide457.9IGF1, INS, LEP, LEPQTL1, RETN, SLPI
43vegf457.7IGF1, SLPI, LEP, LEPQTL1, SELP, EPO
44testosterone45 61 24 1110.6INS, LEP, SLPI, LEPQTL1, EPO, RETN
45dexamethasone45 51 29 1110.5SLPI, RETN, SELP, LEPQTL1, LEP, INS
46estrogen457.5RETN, IGF1, INS, SLPI, SELP, LEPQTL1
47norepinephrine45 24 119.5RETN, AOX1, ACE, INS, LEP, SELP
48glucose457.2LEP, SLPI, AOX1, ACE, RETN, LEPQTL1
49cholesterol45 29 24 1110.2LEPQTL1, LEP, RETN, ACE, SLPI, INS
50creatinine457.0LEP, RETN, EPO, SELP, LEPQTL1, SLPI

GO Terms for genes affiliated with End Stage Renal Failure

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16Gene Ontology
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Cellular components related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5IGF1, INS, LEP, EPO, ACE
2extracellular spaceGO:0056156.9IGF1, INS, LEP, HILPDA, SELP, EPO

Biological processes related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.0LEP, SELP
2negative regulation of feeding behaviorGO:200025210.0INS, RETN
3positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
4positive regulation of smooth muscle cell migrationGO:0149119.9RETN, IGF1
5positive regulation of Ras protein signal transductionGO:0465799.9EPO, IGF1
6bone mineralization involved in bone maturationGO:0356309.8IGF1, LEP
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8EPO, IGF1
8response to insulinGO:0328689.8RETN, LEP
9positive regulation of glycolytic processGO:0458219.7IGF1, INS
10positive regulation of glycogen biosynthetic processGO:0457259.7IGF1, INS
11positive regulation of glucose importGO:0463269.6INS, IGF1
12positive regulation of cytokine productionGO:0018199.6LEP, HILPDA
13positive regulation of DNA replicationGO:0457409.6IGF1, INS, EPO
14blood vessel remodelingGO:0019749.5IGF1, ACE
15positive regulation of mitosisGO:0458409.5INS, IGF1
16positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5SELP, INS, IGF1
17positive regulation of MAPK cascadeGO:0434109.4LEP, INS, IGF1
18positive regulation of smooth muscle cell proliferationGO:0486619.4RETN, IGF1
19positive regulation of cell proliferationGO:0082848.5EPO, HILPDA, LEP, INS, IGF1

Molecular functions related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.4INS, IGF1
2insulin receptor bindingGO:0051589.2INS, IGF1
3hormone activityGO:0051798.5IGF1, RETN, EPO, LEP, INS
4protein bindingGO:0055156.7SLPI, NPHP4, ACE, EPO, SELP, HILPDA

Products for genes affiliated with End Stage Renal Failure

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Sources for End Stage Renal Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet