MCID: END030
MIFTS: 52

End Stage Renal Failure malady

Nephrological diseases category

Summaries for End Stage Renal Failure

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

MalaCards: End Stage Renal Failure, also known as chronic kidney disease stage 5, is related to peritonitis and hypertension. An important gene associated with End Stage Renal Failure is PKD1 (polycystic kidney disease 1 (autosomal dominant)). The compounds estrogen and uric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for End Stage Renal Failure

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

end stage renal failure 8 10
chronic kidney disease stage 5 60
end stage renal disease 8


External Ids:

Disease Ontology8 DOID:783
ICD1025 N18.5

Related Diseases for End Stage Renal Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 332)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.3SELPLG, SLPI
2hypertension31.0CD79A, RETN, PTH
3primary hyperoxaluria30.9GAST, PKD1, CD79A, EPO, PTH
4diabetic nephropathy30.9EPO, CNDP1, AGTR2, UMOD
5peptic ulcer30.8GAST
6vascular disease30.7SELPLG
7hyperparathyroidism30.7GAST, MEN1, EPO, SLPI, PTH
8diabetes mellitus30.7LSL, UMOD, CNDP1, CD79A, RETN, PTH
9tuberculosis30.7LSL, CD79A
10nephrotic syndrome30.6LAMB2, CD79A
11ischemia30.6BDKRB1, AGTR2, SELPLG
12chronic kidney failure30.6PTH, BDKRB1, LSL, UMOD, MEN1, PKD1
13type 2 diabetes mellitus30.5SLPI, RETN, AGTR2, LSL
14thyroiditis30.5CD79A
15renal osteodystrophy30.5PTH, SLPI
16nephronophthisis30.5XPNPEP3
17myeloma30.5UMOD, CD79A, EPO
18hypothyroidism30.5PTH, RETN, LSL
19proteinuria30.5CD79A, AGTR2, UMOD, LSL
20pyelonephritis30.5CD79A, UMOD
21atherosclerosis30.5LSL, AGTR2, RETN, SELPLG
22polycystic kidney disease30.4UMOD, PKD1, EPO
23uremia30.4LSL, MEN1, EPO, RETN, PTH
24viral hepatitis30.2SLPI
25liver cirrhosis30.2SLPI, RETN, LSL
26chronic pyelonephritis30.2UMOD
27obesity30.2RETN, LSL
28hypercalcemia30.2GAST, MEN1, SLPI, PTH
29breast cancer30.2MEN1, AGTR2, PKD1, PTH
30leukemia30.2MEN1, CD79A, EPO, SLPI, SELPLG
31cystic kidney30.2UMOD, PKD1
32gout30.2UMOD
33von hippel-lindau disease30.2MEN1, PKD1
34acute myocardial infarction30.2RETN
35esophagitis30.2GAST
36myocardial infarction30.2LSL, AGTR2, RETN, SELPLG
37renal hypertension10.7
38hyperphosphatemia10.7
39amyloidosis10.6
40kidney disease10.6
41systemic lupus erythematosus10.5
42lupus erythematosus10.5
43hepatitis10.5
44arteriovenous fistula10.5
45renal tuberculosis10.5
46glomerulonephritis10.5
47renal vascular disease10.5
48periodontal disease10.4
49periodontitis10.4
50calciphylaxis10.4

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to end stage renal failure

Clinical Features for End Stage Renal Failure

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Drugs & Therapeutics for End Stage Renal Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for End Stage Renal Failure

Drug clinical trials:

Search ClinicalTrials for End Stage Renal Failure

Search NIH Clinical Center for End Stage Renal Failure

Search CenterWatch for End Stage Renal Failure

Genetic Tests for End Stage Renal Failure

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Anatomical Context for End Stage Renal Failure

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32MalaCards
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MalaCards organs/tissues related to End Stage Renal Failure:

32
Kidney, Heart, Bone, Liver, T cells, Pancreas, Endothelial, Testes, Bone marrow, Thyroid, Lung, Breast, Skin, Myeloid, Monocytes, Skeletal muscle, Pituitary

Animal Models for End Stage Renal Failure or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to End Stage Renal Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2UMOD, AGTR2, PKD1, CD79A, LAMB2, SELPLG
2MP:00053769.8SELPLG, BDKRB1, UMOD, GAST, MEN1, AGTR2
3MP:00053879.7MEN1, GAST, UMOD, BDKRB1, PKD1, CD79A

Publications for End Stage Renal Failure

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Sources:
50PubMed
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Articles related to End Stage Renal Failure:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Outcome of early initiation of peritoneal dialysis in patients with end-stage renal failure. (22323864)
2012
2
Disseminated amyloidosis presenting with right proximal femur pathological fracture in a haemodialysis end-stage renal failure patient. (22147322)
2011
3
Side effects of oseltamivir in end-stage renal failure patients. (21193643)
2011
4
Marine n-3 polyunsaturated fatty acids in patients with end-stage renal failure and in subjects without kidney disease: a comparative study. (20833075)
2011
5
Cardiac valve replacement in patients with end-stage renal failure: impact of prosthesis type on the early postoperative course. (20072972)
2010
6
Reduced clearance of rocuronium and sugammadex in patients with severe to end-stage renal failure: a pharmacokinetic study. (20007792)
2010
7
End stage renal failure mimicking as acute renal failure in developing countries. (20058588)
2009
8
Open heart surgery in patients with end-stage renal failure: fifteen-year experience. (18778299)
2009
9
Amanita phalloides poisoning-induced end-stage renal failure. (19473620)
2009
10
Arteriovenous fistula affects bone mineral density measurements in end-stage renal failure patients. (19713298)
2009
11
Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure. (19289295)
2009
12
Who does not need a statin: too late in end-stage renal disease or heart failure? (19417167)
2009
13
Extent and severity of coronary disease and mortality in patients with end-stage renal failure evaluated for renal transplantation. (19538490)
2009
14
Outcomes for dialysis patients with end-stage renal failure admitted to an intensive care unit or high dependency unit. (18312194)
2008
15
End-stage renal failure, reflux nephropathy and Feingold's syndrome. (17849152)
2008
16
Calciphylaxis with a protracted course in a patient with end-stage renal failure. (17298109)
2007
17
Dynamic left ventricular outflow track obstruction in a patient with end-stage renal failure on haemodialysis: excessive volume extraction and sympathetic activation may be the possible causes. (16930748)
2007
18
Relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients. (17617053)
2007
19
Changes of heme oxygenase-1 and inflammatory factors in patients with end-stage renal failure following hemodialysis]. (17425995)
2007
20
Relation between different treatment modalities and genomic damage of end-stage renal failure patients. (16582572)
2006
21
Laparoscopic implantation of the Tenckhoff catheter for the treatment of end-stage renal failure and congestive heart failure: experience with the pelvic fixation technique. (16599052)
2006
22
Dysregulation of IL-2/IL-2R system alters proliferation of early activated CD4+ T cell subset in patients with end-stage renal failure. (15678692)
2005
23
Skeletal status in adolescents with end-stage renal failure: a longitudinal study. (15221204)
2005
24
Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis. (15658577)
2004
25
Counselling should be offered to people with end-stage renal failure. (15163032)
2004
26
Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: a meta-analysis of randomized trials. (15579523)
2004
27
End-stage renal failure and cardiac mortality after heart transplantation. (15108764)
2004
28
The effect of sildenafil on gastric emptying in patients with end-stage renal failure and symptoms of gastroparesis. (15371988)
2004
29
Assessing glycemic control in patients with diabetes and end-stage renal failure. (12612974)
2003
30
Spontaneous rupture of non-tumoral kidneys in patients with end stage renal failure: risks and management. (12814684)
2003
31
The incidence of end-stage renal failure in 17 years of heart transplantation: a single center experience. (12057698)
2002
32
Long-term impact of renal transplantation on carotid artery properties and on ventricular hypertrophy in end-stage renal failure patients. (11917059)
2002
33
Improvement in ejection fraction by nocturnal haemodialysis in end-stage renal failure patients with coexisting heart failure. (12147805)
2002
34
End-stage renal failure in Indo-Asian in the UK: a double whammy. (12042634)
2002
35
Impact of simultaneous pancreas and kidney transplantation on progression of coronary atherosclerosis in patients with end-stage renal failure due to type 1 diabetes. (11978689)
2002
36
Palliative nursing care for the patient experiencing end-stage renal failure. (11998648)
2001
37
Uraemic symptoms, nutritional status and renal function in pre-dialysis end-stage renal failure patients. (11274273)
2001
38
An unusual rash and end-stage renal failure. (11291470)
2001
39
Long-term results justify autogenous infrainguinal bypass grafting in patients with end-stage renal failure. (11436071)
2001
40
TNF-alpha: mRNA, plasma protein levels and soluble receptors in patients on chronic hemodialysis, on CAPD and with end-stage renal failure. (10711413)
2000
41
Polymorphism of the angiotensin-converting enzyme gene in end-stage renal failure patients. (10773756)
2000
42
Brown tumor as manifestation of parathyroid hyperplasia in two cases with end-stage renal failure. (10050098)
1999
43
Proteinuria predicts end-stage renal failure in non-diabetic chronic nephropathies. The "Gruppo Italiano di Studi Epidemiologici in Nefrologia" (GISEN). (9407422)
1997
44
Cardiac surgery in patients with end-stage renal failure. (9352160)
1997
45
Progression of peripheral vascular disease after combined kidney-pancreas transplantation in diabetic patients with end-stage renal failure. (9123467)
1997
46
Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure. (9017621)
1996
47
A computer model for predicting the demand for end-stage renal failure (ESRF) treatment, contract setting and monitoring. (8672024)
1996
48
Psychosocial care in end-stage renal failure. (9128659)
1996
49
Effects of erythropoietin therapy on the lipid profile in end-stage renal failure. (8196294)
1994
50
Soluble interleukin 2 receptor and tissue polypeptide antigen serum concentrations in end-stage renal failure. (2243570)
1990

Genetic Variations for End Stage Renal Failure

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Expression for genes affiliated with End Stage Renal Failure

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for genes affiliated with End Stage Renal Failure

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Compounds for genes affiliated with End Stage Renal Failure

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to End Stage Renal Failure according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CD79A
2uric acid44 2411.7SLPI, UMOD
3deoxypyridinoline4410.7PTH, LSL
4captopril44 28 49 59 1114.7CD79A, AGTR2, BDKRB1
5norepinephrine44 11 2412.6GAST, AGTR2, RETN, SLPI
6sialic acid4410.6LSL, UMOD, CD79A, EPO, SELPLG
7methacholine44 1111.6GAST, CD79A, SLPI
8urea44 11 2412.6LSL, UMOD, EPO, RETN, SLPI
9cycloheximide4410.6BDKRB1, PTH
10c-peptide4410.6LSL, GAST, RETN, SLPI
11carbachol44 28 1112.6GAST, CD79A, SLPI, PTH
12hydrocortisone44 2 59 1113.6LSL, GAST, EPO, SLPI
13vitamin d4410.6GAST, MEN1, CD79A, EPO, SLPI, PTH
14vitamin b124410.6GAST, CD79A, EPO
15thyroxine44 2411.6LSL, GAST, CD79A, RETN, PTH
16octreotide44 59 28 1113.6EPO, GAST, LSL
17calcitriol44 59 11 2413.6GAST, EPO, SLPI, PTH
18fludrocortisone44 28 1112.6EPO, LSL
19sodium44 2411.6UMOD, AGTR2, PKD1, RETN, SLPI, PTH
20malondialdehyde4410.6SLPI, EPO, LSL
21fibrinogen4410.5LSL, CD79A, RETN, SLPI, SELPLG
22heparin44 28 11 2413.5LSL, UMOD, GAST, CD79A, SLPI, LAMB2
23thymidine44 2411.5GAST, MEN1, EPO, SLPI, PTH
24testosterone44 59 11 2413.5LSL, GAST, PKD1, CD79A, EPO, RETN
25vegf4410.5LSL, GAST, MEN1, CD79A, EPO, RETN
26alanine4410.5LSL, GAST, AGTR2, PKD1, CD79A, RETN
27dexamethasone44 49 28 1113.5LSL, GAST, CD79A, RETN, SLPI, PTH
28aprotinin44 1111.4PTH, SLPI, EPO
29ascorbic acid44 2411.4GAST, CD79A, EPO, SLPI
30creatinine4410.4PTH, LSL, UMOD, GAST, AGTR2, CD79A
31nitric oxide44 11 2412.4BDKRB1, LSL, AGTR2, RETN, SLPI, PTH
32pneumococcal4410.4PKD1, CD79A
33tyrosine4410.4BDKRB1, GAST, MEN1, AGTR2, PKD1, EPO
34oxygen44 2411.3LSL, AGTR2, EPO, RETN, SLPI, SELPLG
35calcium44 49 11 2413.3MEN1, GAST, UMOD, LSL, BDKRB1, AGTR2
36azathioprine44 49 2 1113.2SLPI, EPO, CD79A
37glucose4410.2LSL, UMOD, GAST, RETN, SLPI, PTH
38cholesterol44 28 11 2413.2SELPLG, SLPI, RETN, LSL, BDKRB1
39histamine44 28 2412.0GAST, CD79A, SLPI, SELPLG

GO Terms for genes affiliated with End Stage Renal Failure

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16Gene Ontology
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Cellular components related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1PTH, SLPI, RETN, EPO, CNDP1, AGTR2

Biological processes related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metanephric ascending thin limb developmentGO:07221810.4PKD1, UMOD

Molecular functions related to End Stage Renal Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.3PTH, RETN, EPO, GAST

Products for genes affiliated with End Stage Renal Failure

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Sources for End Stage Renal Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet