MCID: END028
MIFTS: 35

Endemic Goiter malady

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

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Aliases & Descriptions for Endemic Goiter:

Name: Endemic Goiter 11 50 13 68
Iodine-Deficiency-Related Endemic Goitre 11
Euthyroid Goiter 68
 
Goiter, Endemic 39
Simple Goitre 11

Classifications:



External Ids:

Disease Ontology11 DOID:13198
ICD1030 E01.0, E01.2
ICD9CM32 240.0
MeSH39 D006043
NCIt45 C35023

Summaries for Endemic Goiter

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MalaCards based summary: Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to nontoxic goiter and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways are Amine-derived hormones and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, testes and cortex.

Related Diseases for Endemic Goiter

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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1nontoxic goiter11.0
2goiter, multinodular 1, with or without sertoli-leydig cell tumors11.0
3goiter10.9
4thyroiditis10.6
5fibrous meningioma10.2TG, TPO
6premature closure of the arterial duct10.1TG, TPO
7congenital nonspherocytic hemolytic anemia10.1SERPINA7, TPO
8echinostomiasis10.1SERPINA7, TG
9tick paralysis10.1TG, TPO
10frontal sinusitis10.1TG, TPO
11acute hemorrhagic encephalitis10.1TG, TSHR
12gastrinoma10.1TG, TSHR
13mesocardia10.1TG, TSHR
14parachordoma10.1TG, TSHR
15color blindness10.1TG, TPO
16thyroid cancer10.0
17dysautonomia, familial10.0TG, TPO
18extrahepatic bile duct adenocarcinoma10.0SERPINA7, TG, TPO
19hypothyroidism10.0
20neuhauser daly magnelli syndrome10.0TG, TPO, TSHR
21conjunctival deposit10.0TG, TPO, TSHR
22nodular prostate10.0TG, TPO, TSHR
23denys-drash syndrome10.0TG, TPO, TSHR
24peritoneal serous papillary adenocarcinoma10.0TG, TPO, TSHR
25neuronopathy, distal hereditary motor, type viia10.0SERPINA7, TG, TSHR
26choreoathetosis, hypothyroidism, and neonatal respiratory distress10.0TG, TPO, TSHR
27tenosynovitis of foot and ankle10.0TG, TPO, TSHR
28muscular dystrophy-dystroglycanopathy , type a, 1010.0TG, TPO, TSHR
29articulation disorder10.0TG, TPO, TSHR
30acute laryngitis9.9TG, TSHR
31dihydrolipoamide dehydrogenase deficiency9.9TG, TPO
32peritoneal mesothelioma9.9TG, TPO, TSHR
33caudal regression syndrome9.9TG, TPO, TSHB
34mixed eosinophil-basophil adenoma9.8SERPINA7, TG, TPO, TSHR
35hypothyroidism, congenital, nongoitrous, 19.8SERPINA7, TG, TPO, TSHR
36broad ligament malignant neoplasm9.8SERPINA7, TG, TPO, TSHR
37janus kinase-3 deficiency9.8SERPINA7, TG, TPO, TSHR
38glomangiomyoma9.8SERPINA7, TG, TPO, TSHR
39pulsating exophthalmos9.8SERPINA7, TG, TPO, TSHR
40multinodular goiter9.8
41hyperparathyroidism9.8
42cerebritis9.8
43exanthema subitum9.8DICER1, TG, TPO, TSHR
44non-distal monosomy 10q9.8DICER1, TG, TPO, TSHR
45commensal bacterial infectious disease9.7TG, TPO, TSHB, TSHR
46diabetes mellitus, insulin-dependent, 129.7TG, TPO, TSHB, TSHR
47insulin-like growth factor i9.7
48angiosarcoma9.7
49tracheomalacia9.7
50tonsillitis9.7

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms & Phenotypes for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Micronutrients6001
2Trace Elements6001
3
Iodine5707553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
4cadexomer iodine537
5Anti-Infective Agents, Local1880
6Anti-Infective Agents22062

Interventional clinical trials:

idNameStatusNCT IDPhase
1Maternal Iodine Supplementation and Effects on Thyroid Function and Child DevelopmentCompletedNCT00791466
2Exploration of Effects of Excessive Iodine on Children and Tolerable Upper Intake Level of Iodine for ChildrenCompletedNCT02915536

Search NIH Clinical Center for Endemic Goiter


Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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MalaCards organs/tissues related to Endemic Goiter:

36
Thyroid, Testes, Cortex, Pituitary, Tonsil, Bone

Publications for Endemic Goiter

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Articles related to Endemic Goiter:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. (26949559)
2016
2
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. (25289092)
2014
3
Surgical treatment of endemic goiter in a nonhospital setting without general anesthesia in Africa. (24728536)
2014
4
The Association between Cobalt Deficiency and Endemic Goiter in School-Aged Children. (25309789)
2014
5
Role of bamboo-shoot in the pathogenesis of endemic goiter in manipur, north East India. (23186959)
2013
6
State of the art: surgery for endemic goiter. (22083604)
2012
7
Single lobe disease in cases of advanced endemic goiter: a new phenotype. (24783020)
2012
8
Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region. (22302284)
2012
9
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
10
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
11
State of the art: surgery for endemic goiter--a plea for individualizing the extent of resection instead of heading for routine total thyroidectomy. (21630080)
2011
12
Thyroid autoimmunity role in the evolution of endemic goiter in rural area, Fars, Iran. (21529102)
2011
13
INCAP studies of endemic goiter and its prevention. (20461908)
2010
14
Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. (19474675)
2009
15
Evidence of endemic goiter and iodine deficiency in a mountainous area of Haiti. (19454392)
2009
16
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. (19494708)
2009
17
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India. (19554805)
2009
18
Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter. (20302029)
2009
19
Iodine deficiency and endemic goiter: a national tragedy. (18599928)
2008
20
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
21
Endemic goiter in Semirom; there is no difference in vitamin A status between goitrous and nongoitrous children. (19155579)
2008
22
The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity. (17324915)
2007
23
Endemic goiter due to thyroglobulin gene abnormality and social ostracism. (17446654)
2007
24
Evaluation of endemic goiter prevalence in Bulgarian schoolchildren: results from national strategies for prevention and control of iodine-deficiency disorders. (17709907)
2007
25
High incidence of tracheomalacia in longstanding goiters: experience from an endemic goiter region. (17354028)
2007
26
Clinical importance of solitary thyroid nodule of the thyroid in endemic goiter region. (16790952)
2006
27
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
28
Clinical importance of solitary solid nodule of the thyroid in endemic goiter region. (16199924)
2005
29
Accuracy of preoperative pinhole subtraction single photon emission computed tomography for patients with primary and recurrent hyperparathyroidism in an endemic goiter area. (15170543)
2004
30
Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region. (15027890)
2004
31
Application of staging systems for differentiated thyroid carcinoma in an endemic goiter region with iodine substitution. (12560781)
2003
32
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. (12660642)
2003
33
Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter area. (12762644)
2003
34
Impact of localization studies on feasibility of minimally invasive parathyroidectomy in an endemic goiter region. (12691928)
2003
35
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. (12666822)
2002
36
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
37
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
38
Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. (12207166)
2002
39
Endemic goiter--an update. (17018443)
2002
40
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
41
Limited sensitivity of parathyroid imaging with (99m)Tc-sestamibi/(123)I subtraction in an endemic goiter area. (12215555)
2002
42
Dietary supplies of iodine and thiocyanate in the etiology of endemic goiter in Tripura. (11407152)
2001
43
Changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter. (11258455)
2001
44
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
45
Endemic goiter and cretinism: an update on iodine status. (11837501)
2001
46
Endemic goiter, thiocyanate overload, and selenium status in school-age children. (11330518)
2001
47
Minimally invasive open parathyroidectomy in an endemic goiter area: a prospective study. (11448396)
2001
48
Endemic goiter with iodine sufficiency: a possible role for the consumption of pearl millet in the etiology of endemic goiter. (10617947)
2000
49
Endemic goiter associated with high iodine intake. (11030003)
2000
50
Short-term effectiveness of mandatory iodization of table salt, at an elevated iodine concentration, on the iodine and goiter status of schoolchildren with endemic goiter. (10617949)
2000

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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GO Terms for genes affiliated with Endemic Goiter

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Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.1TG, TPO
2hormone-mediated signaling pathwayGO:00097559.1TSHB, TSHR

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.2TG, TSHB

Sources for Endemic Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet