MCID: END028
MIFTS: 47

Endemic Goiter malady

Endocrine diseases category

Summaries for Endemic Goiter

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MalaCards: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Insulin secretion and Allograft rejection. The compounds cycloheximide and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Endemic Goiter

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

endemic goiter 8 44 60
iodine-deficiency-related goitre, unspecified 8
iodine-deficiency-related goiter, unspecified 8
iodine-deficiency-related endemic goiter 8
iodine-deficiency-related endemic goitre 8
goiter, specified as simple 8
simple goiter 8
simple goitre 8


External Ids:

Disease Ontology8 DOID:13198
ICD9CM27 240.0
NCIt39 C35023
MeSH34 D006043
ICD1025 E01.2

Related Diseases for Endemic Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.9TG, TPO, TSHR, SERPINA7, TRH
2thyroiditis31.4TRH, SERPINA7, TSHR, TPO, TG
3thyroid cancer30.6TG, TPO, TSHR, TRH
4hypothyroidism30.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG
5thyrotoxicosis30.5TRH, SERPINA7, TSHR, TPO, TG
6autoimmune thyroiditis30.4TPO, TG
7multinodular goiter30.3TSHR, TPO, TG
8nontoxic goiter30.1TG, TPO, TSHR
9follicular thyroid carcinoma30.1TSHR, TG
10nodular goiter30.1TSHR, TPO, TG
11adenoma30.0TG, TPO, TSHR, TRH, IGFBP3
12hyperthyroidism30.0TRH, SERPINA7, TSHR, TPO, TG
13pendred syndrome30.0TG, TPO
14cerebritis10.2
15hyperparathyroidism10.2
16acute thyroiditis10.1
17primary hyperparathyroidism10.1
18chagas disease10.1
19mutism10.1
20tonsillitis10.1
21thyroid medullary carcinoma10.1
22parathyroid adenoma10.1
23neurologic diseases10.1
24turner syndrome10.0IGFBP3
25diabetes mellitus10.0IGFBP3
26infertility10.0TPO
27subacute thyroiditis10.0TG
28dwarfism10.0IGFBP3
29neonatal thyrotoxicosis10.0TSHR
30breast cancer10.0IGFBP3
31anovulation10.0IGFBP3
32diabetes insipidus10.0TRH
33endogenous depression10.0TRH
34cushing's syndrome10.0TRH
35empty sella syndrome10.0TRH
36pernicious anemia10.0TPO, TG
37addison's disease10.0TG, TPO
38plummer's disease10.0TPO, TG
39thyrotropin deficiency, isolated10.0TPO, TG
40renal clear cell carcinoma10.0IGFBP3
41struma ovarii10.0TSHR, TG
42pregnancy loss10.0TPO, TG
43down syndrome10.0TPO, TSHR
44hyperprolactinemia10.0TRH
45hepatitis10.0SERPINA7
46celiac disease10.0TG, TPO
47premature ovarian failure10.0IGFBP3, TPO
48li-fraumeni syndrome10.0IGFBP3, TPO
49precocious puberty10.0TSHR, IGFBP3
50toxic diffuse goiter10.0TG, TPO, TSHR

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Clinical Features for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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32MalaCards
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MalaCards organs/tissues related to Endemic Goiter:

32
Thyroid, Testes, Cortex, Bone, Tonsil, Pituitary

Animal Models for Endemic Goiter or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endemic Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TG, TPO, TSHR, TRH, IGFBP3
2MP:00053797.6TG, TPO, TSHR, TRH, IGFBP3
3MP:00053787.4IGFBP3, TRH, TSHR, TPO, TG

Publications for Endemic Goiter

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50PubMed
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Articles related to Endemic Goiter:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
2
INCAP studies of endemic goiter and its prevention. (20461908)
2010
3
Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter. (20302029)
2009
4
Clinical importance of solitary thyroid nodule of the thyroid in endemic goiter region. (16790952)
2006
5
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. (12660642)
2003
6
The relative roles of endemic goiter and socioeconomic development status in the prognosis of thyroid carcinoma. (9506362)
1998
7
Goiter prevalence in children immigrating from an endemic goiter area in Ethiopia to Israel. (7584706)
1995
8
The prevalence of thyroid dysfunction among elderly subjects in an endemic goiter area of Central Anatolia. (8574297)
1995
9
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
10
Is endemic goiter an autoimmune disease? (7909815)
1994
11
Iodized salt prophylaxis of endemic goiter: an experience in Toscana (Italy). (8109181)
1993
12
Serum TSH, FT3, and FT4 levels in inhabitants of an endemic goiter area in China supplied iodized salt for twenty-five years. (2638910)
1989
13
Determination of SCN--in vegetables by gas chromatography in relation to endemic goiter. (3244270)
1988
14
Vitamin A status and endemic goiter. (3170087)
1988
15
Circadian and circannual variations of thyroid function in children 11 +/- 1.5 years of age with and without endemic goiter. (3628335)
1987
16
Iodine vs thyroxine. A changing concept of therapy in endemic goiter? (3626427)
1987
17
Thyroid autoimmunity and endemic goiter. (3486111)
1986
18
Increased serum thyroglobulin concentrations and impaired thyrotropin response to thyrotropin-releasing hormone in euthyroid subjects with endemic goiter in Sicily: their relation to goiter size and nodularity. (3098822)
1986
19
Total blood thyroxine and TSH levels in the newborns of an endemic goiter area in Romania. (7027428)
1981
20
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
21
Local injection of iodine tincture in endemic goiter. (417908)
1978
22
Prediction of malignancy in solitary thyroid nodules in a country with endemic goiter. (984308)
1976
23
The effect of iodized oil on the TSH response to TRH in endemic goiter patients. (169288)
1975
24
Thyroxine (T4) and triiodothyronine (T3): effects of iodine on the serum concentrations and disposal rates in subjects from an endemic goiter area. (4815170)
1974
25
Prevention of endemic goiter and the ten-year health plan for Americas. (4419747)
1974
26
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
27
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
28
Biochemical defects in thyroid hormone synthesis and their relation to endemic goiter. (4523770)
1973
29
The incidence as a function of age of thyroid dysfunction for two populations living in a goitrogenic environment. Pathogenesis of endemic goiter. (4133048)
1973
30
Iodine deficiency, environmental goitrogens and genetic factors in the etiology of endemic goiter. (4523771)
1973
31
Endemic goiter. (5087476)
1971
32
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
33
Endemic goiter in Greece: effects of iodized oil injection. (4317038)
1970
34
Research on endemic goiter in Latin America. (5501148)
1970
35
Endemic goiter in the Cauca Valley. I. Results and limitations of twelve years of iodine prophylaxis. (5699948)
1968
36
Thyroid carcinoma in an endemic goiter area, Cali, Colombia. (5900688)
1966
37
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
38
Endemic goiter. II. Pathophysiology and pathology. (14471216)
1962
39
Endemic goiter in Alaska. (14493072)
1962
40
Endemic goiter in the Uele region (Republic of Congo). I. General aspects and functional studies. (13720924)
1961
41
Prevention of endemic goiter and evaluation of enlargement of the thyroid gland; answer to the critics]. (13658082)
1959
42
Endemic goiter and nutrition. I. A study of some aspects of their relationship in a Brazilian Amazon community. (13649624)
1959
43
Endemic goiter. (13586355)
1958
44
Endemic goiter in Venezuela studied with I 131. (13385322)
1957
45
A special study of endemic goiter in Mexico and the Central and Latin American countries. (13037276)
1953
46
Endemic goiter and cretinism. (18117366)
1949
47
Iodine-lack theory and endemic goiter. (18901293)
1947
48
When was the cause of endemic goiter recognized? (20247887)
1947
49
Is endemic goiter due to a lack of iodine? (20281695)
1946
50
THE PREVENTION OF ENDEMIC GOITER. (18010591)
1921

Genetic Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endemic Goiter

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Pathways for genes affiliated with Endemic Goiter

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29KEGG
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Pathways related to Endemic Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TPO
2
Hide members
9.1TG, TPO, TSHR

Compounds for genes affiliated with Endemic Goiter

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44Novoseek, 24HMDB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Endemic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.3TRH
2iodotyrosine44 2411.0TG, TPO
3diiodotyrosine4410.0TG, TPO
4perchlorate4410.0TPO, TG
5carbimazole44 1110.8TSHR, TPO
6gliadin449.8TG, TPO
7chromium449.7TPO
8amino acid449.7TPO, TSHR
9Liothyronine11 2410.6SERPINA7, TPO
10sodium iodide449.5TSHR, TPO, TG
11propylthiouracil44 2 1111.5TG, TPO, TSHR
12ghrp449.4TRH, IGFBP3
13hydrocortisone44 2 59 1112.4TRH, TPO, TG
14amiodarone44 49 28 1112.4TG, TPO, SERPINA7
15isoflavone449.4IGFBP3, TPO
16maltose44 1110.4TSHR, TPO
17pyridostigmine44 1110.4TRH, IGFBP3
18sodium dodecylsulfate449.4SERPINA7, TPO, TG
19asparagine449.3SERPINA7, TSHR, TPO
20sialic acid449.3TG, TSHR, SERPINA7
21fenfluramine28 44 1111.2TRH, IGFBP3
22agarose449.2SERPINA7, TSHR, TPO
23octreotide44 59 28 1112.1TG, TRH, IGFBP3
24prednisolone44 28 1111.1TG, TSHR, IGFBP3
25carbohydrates449.0IGFBP3, TSHR, TG
26125i448.9SERPINA7, TSHR, TPO, TG
27iodide44 249.9TG, TPO, TSHR, SERPINA7
28vitamin a44 11 2410.9TG, SERPINA7, IGFBP3
29ascorbic acid44 249.8TG, TPO, IGFBP3
30polysaccharide448.7IGFBP3, TSHR, TPO, TG
31thymidine44 249.6TG, TSHR, TRH, IGFBP3
32chloramphenicol44 2 1110.6IGFBP3, SERPINA7, TSHR
33creatinine448.5IGFBP3, SERPINA7, TPO, TG
34iodine44 249.4TRH, SERPINA7, TSHR, TPO, TG
35estradiol44 11 2410.4IGFBP3, TRH, SERPINA7, TSHR
36cholesterol44 28 11 2411.3IGFBP3, SERPINA7, TSHR, TPO
37progesterone44 59 28 11 2412.3IGFBP3, TRH, SERPINA7, TSHR
38tyrosine448.2TRH, SERPINA7, TSHR, TPO, TG
39adenylate448.2TG, TPO, TSHR, TRH, IGFBP3
40glutamate448.2IGFBP3, TRH, TSHR, TPO, TG
41alanine448.1TG, TSHR, SERPINA7, IGFBP3
42ribonucleic acid448.1IGFBP3, SERPINA7, TSHR, TPO, TG
43aspartate448.1IGFBP3, SERPINA7, TSHR, TPO, TG
44testosterone44 59 11 2411.1IGFBP3, TRH, SERPINA7, TPO, TG
45estrogen448.0IGFBP3, TRH, SERPINA7, TSHR, TG
46acth448.0IGFBP3, TRH, SERPINA7, TSHR, TPO
47methimazole44 2 119.6TG, TPO, TSHR, SERPINA7, TRH, IGFBP3
48triiodothyronine447.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG
49thyroxine44 248.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG
50arginine447.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG

GO Terms for genes affiliated with Endemic Goiter

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16Gene Ontology
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Cellular components related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1TG, SERPINA7, TRH, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2response to corticosterone stimulusGO:0514129.3SERPINA7, TRH
3thyroid hormone generationGO:0065909.3TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet