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MCID: END028

Endemic Goiter malady
10 drugs, 6 genes, 1 tissue, 130 related diseases, 2 phenotypes, 9 articles, clinical trials.

Summaries for Endemic Goiter

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44Wikipedia, 22MalaCards
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Wikipedia: A goitre or goiter (Latin gutteria, struma), is a swelling of the thyroid gland, which can lead to a...44 more...

MalaCards: Endemic Goiter, also known as iodine-deficiency-related (endemic) goiter, unspecified (disorder), is related to multinodular goiter and nodular goiter. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways is Autoimmune thyroid disease. The drugs methimazole and thyroid and the compounds glutamate and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotypes are endocrine/exocrine gland and growth/size.

Aliases & Descriptions for Endemic Goiter

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM, 27NCIt
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Aliases & Descriptions:

endemic goiter 6 8 32 43
iodine-deficiency-related (endemic) goiter, unspecified (disorder) 6
iodine-deficiency-related (endemic) goitre, unspecified 6
iodine-deficiency-related endemic goiter (disorder) 6
iodine-deficiency-related endemic goitre 6
goiter, specified as simple 6
iodine deficiency syndrome 43
endemic goiter (disorder) 6
simple goiter (disorder) 6
simple goiter 6
simple goitre 6
goiter 43

Related Diseases for Endemic Goiter

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13GeneCards, 14GeneDecks
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Diseases related to endemic goiter by text searches and GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1multinodular goiter32.8TG, TSHR, TPO, TRH
2nodular goiter32.6TG, TSHR, TPO
3plummer's disease31.0TG, TPO
4goiter30.4TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
5toxic diffuse goiter30.3TG, TSHR, TPO
6hypothyroidism29.8TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
7thyroid carcinoma29.5TRH, TPO, TSHR, TG
8pendred syndrome29.4TG, TPO
9graves' disease29.1TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
10thyroid cancer29.0TRH, TPO, TSHR, TG
11autoimmune thyroiditis28.7TG, TSHR, TPO, SERPINA7
12thyroiditis28.1TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
13carcinoma28.1TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
14papillary thyroid carcinoma27.8TPO, TSHR, TG
15nontoxic goiter27.7TG, TSHR, TPO, TRH
16congenital hypothyroidism27.7TG, TSHR, TPO, SERPINA7
17follicular adenoma27.1TPO, TG
18adenoma26.7TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
19thyroid adenoma25.7TG, TSHR, TPO, TRH, SERPINA7
20hyperthyroidism24.9TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
21total iodide organification defect13.1TPO, TG
22iodine hypothyroidism13.1TPO, TG
23hashimoto's encephalitis13.1TPO, TG
24megaloblastic anemia13.1TG, TPO
25premature menopause13.1TG, TPO
26thyrotropin deficiency, isolated13.1TPO, TG
27limbic encephalitis13.0TG, TPO
28autoimmune polyendocrine syndrome13.0TG, TPO
29subacute thyroiditis13.0TG, TPO
30struma ovarii13.0TG, TSHR
31thyroid hormone metabolism13.0TPO, TG
32sycp3-related pregnancy loss, susceptibility to13.0TPO, TG
33thyroid cancer, follicular13.0TG, TSHR
34thyrotoxic periodic paralysis13.0TSHR, TPO
35diabetic ketoacidosis13.0TPO, TG
36thyroxine-binding globulin deficiency12.9SERPINA7, TG
37premature ovarian failure12.9TPO, IGFBP3
38li-fraumeni syndrome12.9IGFBP3, TPO
39mumps12.8TPO, TG
40hellp syndrome12.7TSHR, TPO
41atrophy of thyroid12.7TRH, TPO
42breast cyst12.7SERPINA7, IGFBP3
43neonatal hypothyroidism12.6TG, TSHR, TPO
44empty sella syndrome12.6TRH, IGFBP3
45neonatal thyrotoxicosis12.6TSHR, TRH
46myxedema12.6TPO, TSHR, TG
47anaplastic carcinoma12.6TPO, TSHR, TG
48thyroid cancer, anaplastic12.6TPO, TSHR, TG
49thyroid medullary carcinoma12.6TG, TSHR, TPO
50myelomeningocele12.6IGFBP3, TRH

Graphical network of the top 20 diseases related to endemic goiter:



Graphical network of diseases related to endemic goiter

Clinical Features for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for endemic goiter

Drug clinical trials:

Search ClinicalTrials for endemic goiter

Search NIH Clinical Center for endemic goiter

Search CenterWatch for endemic goiter

Inferred drug relations via UMLS/NDF-RT:

43 28 levothyroxine, levothyroxine sodium, liothyronine, liothyronine sodium, methimazole, propylthiouracil, thyroglobulin, thyroid, thyroid pwdr [va product], thyroid,bovine

Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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22MalaCards
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MalaCards organs/tissues related to endemic goiter:

22
Thyroid

Phenotypes for genes affiliated with Endemic Goiter

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25MGI
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MGI Mouse Phenotypes related to endemic goiter:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:00053799.4TRH
2growth/size phenotypeMP:00053787.7IGFBP3, TRH, TPO, TSHR, TG

Publications for genes affiliated with Endemic Goiter

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35PubMed
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Articles related to endemic goiter:

idTitleAuthorsYearAffiliating Genes
1Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-d eficient endemic goiter area. (12666822)Aydin K.... Kurtoglu S.2002IGFBP3
2Relationship between intrathyroid calcifications and thyroglobulin in endemic goiter. (10464709)Zaccheroni V.... Lodi A.1999TG
3Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. (9398711)Kahaly G.... Hommel G.1997TG
4Earliest prevention of endemic goiter by iodine supplementation during pregnancy. (8640295)LiesenkAPtter K.P.... GrA1ters A.1996TPO
5Thyroglobulin exon 10 gene point mutation in a patient with endemic goiter. (8936666)PAcrez-Centeno C.... Miralles-GarcA-a J.M.1996TG
6Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter. (7909816)Vitti P.... Pinchera A.1994TPO, TG
7Thyroid status in anemic pregnant women under conditions of endemic goiter (7899433)Zel'tser M.E.... Nugmanova M.I.1994SERPINA7
8Endemic goiter in Ethiopian Jews--possible pathogenetic factors. (8349452)Luboshitzky R.... Flatau E.1993TG
9Thyroid peroxidase in endemic goiter tissue. (2090669)Sugawara M.... Medeiros-Neto G.A.1990TPO, TG

Expression for genes affiliated with Endemic Goiter

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Endemic Goiter

Pathways for genes affiliated with Endemic Goiter

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20KEGG
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Pathways related to endemic goiter according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1Autoimmune thyroid disease209.1TPO, TSHR, TG

Compounds for genes affiliated with Endemic Goiter

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32Novoseek , 18HMDB, 9DrugBank, 34PharmGKB, 42Tocris Bioscience
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Compounds related to endemic goiter according to GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1glutamate32 10.4IGFBP3
2iodotyrosine32 18 11.0TPO, TG
3diiodotyrosine32 10.0TG, TPO
4perchlorate32 10.0TG, TPO
5carbimazole32 9 9 11.9TSHR, TPO
6gliadin32 9.8TG, TPO
7isoflavone32 9.8TPO, IGFBP3
8amino acid32 9.7TPO, TSHR
9liothyronine34 9 18 9 12.7TPO, SERPINA7
10chromium32 9.6TG, TPO
11maltose32 9 9 11.6TSHR, TPO
12sodium iodide32 9.5TG, TSHR, TPO
13propylthiouracil32 9 9 11.5TPO, TSHR, TG
14ghrp32 9.4IGFBP3, TRH
15pyridostigmine32 9 9 11.4IGFBP3, TRH
16amiodarone32 9 9 11.4TG, TPO, SERPINA7
17prednisolone32 9 9 11.4IGFBP3, TSHR, TG
18sodium dodecylsulfate32 9.4SERPINA7, TPO, TG
19fenfluramine32 9 9 11.4IGFBP3, TRH
20asparagine32 9.3SERPINA7, TPO, TSHR
21sialic acid32 9.3SERPINA7, TSHR, TG
22agarose32 9.2TSHR, TPO, SERPINA7
23hydrocortisone32 9 9 11.1TG, TPO, TRH
24octreotide32 42 9 9 12.1TG, TRH, IGFBP3
25vitamin a32 9 18 9 12.1SERPINA7, IGFBP3, TG
26ascorbic acid32 18 10.1IGFBP3, TPO, TG
27levonorgestrel32 9 9 11.0SERPINA7, IGFBP3
28polysaccharide32 9.0IGFBP3, TPO, TSHR, TG
29chloramphenicol32 9 9 10.9SERPINA7, IGFBP3, TSHR
30125i32 8.9TG, TSHR, TPO, SERPINA7
31iodide32 18 9.9SERPINA7, TPO, TSHR, TG
32creatinine32 8.8TG, TPO, IGFBP3, SERPINA7
33cholesterol32 9 18 9 11.6TSHR, TPO, IGFBP3, SERPINA7
34cycloheximide32 8.6TG, TPO, TRH, IGFBP3
35thymidine32 18 9.6TG, TSHR, TRH, IGFBP3
36ribonucleic acid32 8.4TG, TSHR, TPO, IGFBP3, SERPINA7
37estradiol32 9 18 9 11.4TSHR, TRH, IGFBP3, SERPINA7
38aspartate32 8.4TG, TSHR, TPO, IGFBP3, SERPINA7
39progesterone32 42 9 18 9 12.3TSHR, TRH, IGFBP3, SERPINA7
40alanine32 8.3TG, TSHR, IGFBP3, SERPINA7
41adenylate32 8.2IGFBP3, TRH, TPO, TSHR, TG
42iodine32 18 9.1TG, TSHR, TPO, TRH, SERPINA7
43testosterone32 9 18 9 11.1TG, TPO, TRH, IGFBP3, SERPINA7
44estrogen32 8.0TG, TSHR, TRH, IGFBP3, SERPINA7
45acth32 8.0TSHR, TPO, TRH, IGFBP3, SERPINA7
46tyrosine32 7.8TG, TSHR, TPO, TRH, SERPINA7
47methimazole32 9 9 9.6SERPINA7, IGFBP3, TRH, TPO, TSHR, TG
48triiodothyronine32 7.6TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
49thyroxine32 18 8.6TG, TSHR, TPO, TRH, IGFBP3, SERPINA7
50arginine32 7.6TG, TSHR, TPO, TRH, IGFBP3, SERPINA7

GO Terms for genes affiliated with Endemic Goiter

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12Gene Ontology
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Biological processes related to endemic goiter according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.3TPO, TG
2response to corticosterone stimulusGO:0514129.0SERPINA7, TRH

Sources for Endemic Goiter

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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