MCID: END028
MIFTS: 40

Endemic Goiter

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

MalaCards integrated aliases for Endemic Goiter:

Name: Endemic Goiter 12 51 14 69
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 69
Goiter, Endemic 41
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD10 32 E01.0 E01.2
ICD9CM 34 240.0
MeSH 41 D006043
NCIt 46 C35023

Summaries for Endemic Goiter

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and nontoxic goiter. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Iodine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.1 TG TPO
2 nontoxic goiter 30.6 CALCA SERPINA7 TG TPO TSHR
3 goiter 30.3 CALCA SERPINA7 TG TPO TSHR
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.9 TG TPO TSHR
5 acute thyroiditis 29.8 CALCA TG
6 graves disease 1 29.5 SERPINA7 TG TPO TSHR
7 differentiated thyroid carcinoma 29.4 TG TPO TSHR
8 papillary thyroid microcarcinoma 29.3 CALCA TG TSHR
9 multinodular goiter 29.1 CALCA TG TPO TSHR
10 thyroid carcinoma, familial medullary 29.1 CALCA TG
11 hyperthyroidism 29.0 SERPINA7 TG TPO TSHR
12 thyroiditis 29.0 CALCA SERPINA7 TG TPO TSHB TSHR
13 thyroid cancer, nonmedullary, 2 28.9 CALCA TG TPO TSHR
14 hypothyroidism 28.7 SERPINA7 TG TPO TSHB TSHR
15 thyroid cancer 28.5 CALCA TG TPO TSHB TSHR
16 familial thyroid dyshormonogenesis 10.3 TG TPO
17 subacute lymphocytic thyroiditis 10.3 TG TPO
18 plummer's disease 10.2 TG TPO
19 dyshormonogenic goiter 10.2 SERPINA7 TG
20 premature menopause 10.2 TG TPO
21 pernicious anemia 10.2 TG TPO
22 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 TG TPO
23 thyroid hormone resistance, generalized, autosomal dominant 10.2 SERPINA7 TG
24 mucoepidermoid thyroid carcinoma 10.1 CALCA TG
25 suppurative thyroiditis 10.1 CALCA TG
26 thyroid sarcoma 10.1 CALCA TG
27 benign struma ovarii 10.1 TG TSHR
28 aging 10.1
29 athyreosis 10.1 TG TSHR
30 atypical follicular adenoma 10.1 CALCA TG
31 struma ovarii 10.1 TG TSHR
32 pendred syndrome 10.1 TG TPO
33 hypoadrenalism 10.1 CALCA TG
34 turner syndrome 10.1 TG TPO
35 postpartum depression 10.1 CALCA TPO
36 amyloid tumor 10.0 CALCA TG
37 fetal iodine deficiency disorder 10.0
38 ovarian cystic teratoma 10.0 CALCA TG
39 exophthalmos 10.0 TG TSHR
40 blood group, i system 10.0
41 cowden disease 9.9 CALCA TG
42 hyperthyroxinemia 9.9 SERPINA7 TPO TSHR
43 mucoepidermoid carcinoma 9.9 CALCA TG
44 neonatal hypothyroidism 9.9 TG TPO TSHR
45 myxedema 9.9 TG TPO TSHR
46 hyperparathyroidism 9.9
47 cerebritis 9.9
48 hypersensitivity reaction disease 9.9 TG TPO TSHR
49 hypothyroidism, congenital, nongoitrous, 2 9.9 SERPINA7 TG TSHR
50 endocrine gland cancer 9.9 CALCA TG

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 Anti-Infective Agents
3 Anti-Infective Agents, Local
4 cadexomer iodine
5 Micronutrients
6 Trace Elements

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maternal Iodine Supplementation and Effects on Thyroid Function and Child Development Completed NCT00791466

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

38
Thyroid, Testes, Cortex, Pituitary, Tonsil, Bone

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 327)
# Title Authors Year
1
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. ( 28551882 )
2017
2
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. ( 29284787 )
2017
3
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. ( 26949559 )
2016
4
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. ( 25289092 )
2014
5
Surgical treatment of endemic goiter in a nonhospital setting without general anesthesia in Africa. ( 24728536 )
2014
6
The Association between Cobalt Deficiency and Endemic Goiter in School-Aged Children. ( 25309789 )
2014
7
Role of bamboo-shoot in the pathogenesis of endemic goiter in manipur, north East India. ( 23186959 )
2013
8
Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region. ( 22302284 )
2012
9
Single lobe disease in cases of advanced endemic goiter: a new phenotype. ( 24783020 )
2012
10
State of the art: surgery for endemic goiter. ( 22083604 )
2012
11
State of the art: surgery for endemic goiter--a plea for individualizing the extent of resection instead of heading for routine total thyroidectomy. ( 21630080 )
2011
12
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. ( 21523503 )
2011
13
Thyroid autoimmunity role in the evolution of endemic goiter in rural area, Fars, Iran. ( 21529102 )
2011
14
Endemic goiter--individual risk factors necessitate individual treatment. ( 22006052 )
2011
15
INCAP studies of endemic goiter and its prevention. ( 20461908 )
2010
16
Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter. ( 20302029 )
2009
17
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. ( 19494708 )
2009
18
Evidence of endemic goiter and iodine deficiency in a mountainous area of Haiti. ( 19454392 )
2009
19
Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. ( 19474675 )
2009
20
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India. ( 19554805 )
2009
21
Iodine deficiency and endemic goiter: a national tragedy. ( 18599928 )
2008
22
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? ( 18202924 )
2008
23
Endemic goiter in Semirom; there is no difference in vitamin A status between goitrous and nongoitrous children. ( 19155579 )
2008
24
Endemic goiter due to thyroglobulin gene abnormality and social ostracism. ( 17446654 )
2007
25
High incidence of tracheomalacia in longstanding goiters: experience from an endemic goiter region. ( 17354028 )
2007
26
The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity. ( 17324915 )
2007
27
Evaluation of endemic goiter prevalence in Bulgarian schoolchildren: results from national strategies for prevention and control of iodine-deficiency disorders. ( 17709907 )
2007
28
Clinical importance of solitary thyroid nodule of the thyroid in endemic goiter region. ( 16790952 )
2006
29
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. ( 16117293 )
2005
30
Clinical importance of solitary solid nodule of the thyroid in endemic goiter region. ( 16199924 )
2005
31
Accuracy of preoperative pinhole subtraction single photon emission computed tomography for patients with primary and recurrent hyperparathyroidism in an endemic goiter area. ( 15170543 )
2004
32
Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region. ( 15027890 )
2004
33
Application of staging systems for differentiated thyroid carcinoma in an endemic goiter region with iodine substitution. ( 12560781 )
2003
34
Impact of localization studies on feasibility of minimally invasive parathyroidectomy in an endemic goiter region. ( 12691928 )
2003
35
Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter area. ( 12762644 )
2003
36
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. ( 12660642 )
2003
37
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. ( 12199330 )
2002
38
Endemic goiter--an update. ( 17018443 )
2002
39
Limited sensitivity of parathyroid imaging with (99m)Tc-sestamibi/(123)I subtraction in an endemic goiter area. ( 12215555 )
2002
40
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. ( 12666822 )
2002
41
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. ( 12504972 )
2002
42
Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. ( 12207166 )
2002
43
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. ( 11936460 )
2002
44
Thyroid hormone profile in children with goiter in an endemic goiter area. ( 11305795 )
2001
45
Dietary supplies of iodine and thiocyanate in the etiology of endemic goiter in Tripura. ( 11407152 )
2001
46
Changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter. ( 11258455 )
2001
47
Minimally invasive open parathyroidectomy in an endemic goiter area: a prospective study. ( 11448396 )
2001
48
Endemic goiter, thiocyanate overload, and selenium status in school-age children. ( 11330518 )
2001
49
Endemic goiter and cretinism: an update on iodine status. ( 11837501 )
2001
50
Endemic goiter with iodine sufficiency: a possible role for the consumption of pearl millet in the etiology of endemic goiter. ( 10617947 )
2000

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Cellular components related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CALCA SERPINA7 TG TPO TSHB

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.61 CALCA TG TSHB
2 cell-cell signaling GO:0007267 9.5 CALCA TSHB TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.4 CALCA TSHR
4 positive regulation of cAMP biosynthetic process GO:0030819 9.37 CALCA TSHR
5 activation of adenylate cyclase activity GO:0007190 9.26 CALCA TSHR
6 hormone-mediated signaling pathway GO:0009755 9.16 TSHB TSHR
7 hormone biosynthetic process GO:0042446 8.96 TG TPO
8 positive regulation of adenylate cyclase activity GO:0045762 8.62 CALCA TSHR

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA TG TSHB

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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