MCID: END028
MIFTS: 45

Endemic Goiter malady

Endocrine category

Summaries for Endemic Goiter

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64Wikipedia, 33MalaCards
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Wikipedia:64 A goitre or goiter (Latin gutteria, struma), is a swelling of the neck or larynx resulting from... more...

MalaCards: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to thyroid cancer and thyrotoxicosis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Insulin secretion and Allograft rejection. The compounds cycloheximide and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include cortex, thyroid and salivary gland, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Endemic Goiter

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

endemic goiter 8 45 61
iodine-deficiency-related goitre, unspecified 8
iodine-deficiency-related goiter, unspecified 8
iodine-deficiency-related endemic goiter 8
iodine-deficiency-related endemic goitre 8
goiter, specified as simple 8
simple goiter 8
simple goitre 8


External Ids:

Disease Ontology8 DOID:13198
ICD9CM27 240.0
NCIt40 C35023
MeSH35 D006043
ICD1025 E01.2

Related Diseases for Endemic Goiter

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer30.7TG, TPO, TSHR, TRH
2thyrotoxicosis30.5TRH, SERPINA7, TSHR, TPO, TG
3multinodular goiter30.3TSHR, TPO, TG
4thyroiditis30.3TRH, SERPINA7, TSHR, TPO, TG
5nontoxic goiter30.1TG, TPO, TSHR
6nodular goiter30.1TSHR, TPO, TG
7adenoma30.1TG, TPO, TSHR, TRH, IGFBP3
8autoimmune thyroiditis30.1TPO, TG
9pendred syndrome30.1TG, TPO
10primary hyperparathyroidism10.1
11chagas disease10.1
12mutism10.1
13thyroid medullary carcinoma10.1
14mental retardation10.1
15turner syndrome10.0IGFBP3
16diabetes mellitus10.0IGFBP3
17infertility10.0TPO
18subacute thyroiditis10.0TG
19dwarfism10.0IGFBP3
20neonatal thyrotoxicosis10.0TSHR
21breast cancer10.0IGFBP3
22anovulation10.0IGFBP3
23diabetes insipidus10.0TRH
24endogenous depression10.0TRH
25cushing's syndrome10.0TRH
26empty sella syndrome10.0TRH
27pernicious anemia10.0TPO, TG
28addison's disease10.0TG, TPO
29plummer's disease10.0TPO, TG
30thyrotropin deficiency, isolated10.0TPO, TG
31renal clear cell carcinoma10.0IGFBP3
32struma ovarii10.0TSHR, TG
33follicular thyroid carcinoma10.0TSHR, TG
34pregnancy loss10.0TPO, TG
35down syndrome10.0TPO, TSHR
36hyperprolactinemia10.0TRH
37hepatitis10.0SERPINA7
38celiac disease10.0TG, TPO
39premature ovarian failure10.0IGFBP3, TPO
40li-fraumeni syndrome10.0IGFBP3, TPO
41precocious puberty10.0TSHR, IGFBP3
42toxic diffuse goiter10.0TG, TPO, TSHR
43amenorrhea10.0TRH
44myxedema10.0TG, TPO, TSHR
45thyroid cancer, anaplastic10.0TG, TPO, TSHR
46follicular adenoma10.0TG, TPO, TSHR
47acromegaly10.0TRH, IGFBP3
48papillary carcinoma10.0TG, TPO, TSHR
49papillary thyroid carcinoma10.0TG, TPO, TSHR
50deficiency anemia10.0SERPINA7, TRH

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Clinical Features for Endemic Goiter

Drugs & Therapeutics for Endemic Goiter

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endemic Goiter

Drug clinical trials:

Search ClinicalTrials for Endemic Goiter

Search NIH Clinical Center for Endemic Goiter

Search CenterWatch for Endemic Goiter

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

Sources:
33MalaCards
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MalaCards organs/tissues related to Endemic Goiter:

33
Cortex, Thyroid, Salivary gland, Tonsil, Fetal thyroid, Pituitary

Animal Models for Endemic Goiter or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Endemic Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TG, TPO, TSHR, TRH, IGFBP3
2MP:00053797.6TG, TPO, TSHR, TRH, IGFBP3
3MP:00053787.4IGFBP3, TRH, TSHR, TPO, TG

Publications for Endemic Goiter

Sources:
51PubMed
See all sources

Articles related to Endemic Goiter:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Indications for surgery and significance of unrecognized cancer in endemic multinodular goiter. (22395348)
2012
2
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. (19494708)
2009
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
High incidence of tracheomalacia in longstanding goiters: experience from an endemic goiter region. (17354028)
2007
5
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
6
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
7
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
8
Endemic goiter, thiocyanate overload, and selenium status in school-age children. (11330518)
2001
9
Short-term effectiveness of mandatory iodization of table salt, at an elevated iodine concentration, on the iodine and goiter status of schoolchildren with endemic goiter. (10617949)
2000
10
Elevated anti-galactosyl antibody titers in endemic goiter. (10365681)
1999
11
Management of hyperparathyroidism in an endemic goiter area. (9494424)
1998
12
Earliest prevention of endemic goiter by iodine supplementation during pregnancy. (8640295)
1996
13
Endemic goiter in the Lemanak and Ai river villages of Sarawak. (7777929)
1994
14
Endemic goiter. (7704809)
1994
15
Endemic goiter and endemic thyroid disorders. (2031356)
1991
16
Ouham-PendAc: a new endemic goiter area in the Centroafrican Republic (CAR): epidemiological survey on 7621 subjects. (1724913)
1990
17
Thyroid peroxidase in endemic goiter tissue. (2090669)
1990
18
Circadian and seasonal variations in iodine excretion in children with and without endemic goiter. (2799241)
1989
19
Management of goiter and thyroid nodules in an area of endemic goiter. (3551146)
1987
20
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
21
Endemic goiter in western Colombia. (6398216)
1983
22
Morphologic studies of therapeutically aborted fetus thyroid in an endemic goiter region of Guizhou Province. (6814849)
1982
23
Endemic goiter morbidity in Timis county after 30 years of iodine prophylaxis. A dynamic study. (7384732)
1980
24
Evolution of endemic goiter in the Valea Jiului area after 30 years of iodine prophylaxis. (523945)
1979
25
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
26
Endemic goiter and antithyroid agents. (49867)
1975
27
Thyroid cancer, Quervain's thyroiditis and Hashimoto's disease in an endemic goiter Andean area. (4523785)
1973
28
Endemic goiter prevention by iodized oil: a reassessment. (4350351)
1973
29
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
30
Role of a dietary goitrogen in the etiology of endemic goiter on Idjw Island. (5116479)
1971
31
Iodine content and ratio of S19 to S27 thyroglobulin in endemic goiter from Ecuador. (5438959)
1970
32
Endemic goiter in the Cauca Valley. II. Studies of thyroid pathophysiology. (5781780)
1969
33
Prophylaxis and treatment of endemic goiter in Peru with iodized oil. (4310499)
1969
34
The value of PBI and T3 test in an endemic goiter area. (4190924)
1969
35
Iodine deficiency, a permissive condition in the development of endemic goiter. (4169597)
1968
36
Effect of iodized oil on serum TSH determined by immunoassay in endemic goiter subjects. (4301474)
1968
37
Endemic goiter in Pedregoso (Chile). 1. Description and function studies. (4164538)
1967
38
A comparative study of the resin uptake of radioactive triodothyronine and other radioiodine tests in the differential diagnosis of endemic goiter and other thyroid diseases. (6032626)
1967
39
Endemic goiter in Greece: an iodine balance study in the field. (4167506)
1967
40
Iodized salt in the prevention of endemic goiter: a world-wide survey of present programs. (4293370)
1967
41
Endemic goiter in the Ueles: a study of thyroxine-binding proteins. (4158689)
1965
42
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
43
Endemic goiter in Upper Galilee. (13872462)
1961
44
Endemic goiter in Latin America. (14444295)
1960
45
Iodine-131 thyroid uptake study of endemic goiter patients in Taiwan. (14404348)
1960
46
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
47
Endemic goiter in Costa Rican school children. (13362660)
1956
48
Iodine metabolism in a region of endemic goiter. (13323037)
1956
49
Endemic Goiter in Louisville and Jefferson County Schools: With Evidence of Family History, Defective Teeth, Tonsils, Chest Expansion, and Use of Iodized Salt. (18012852)
1929
50
Endemic Goiter and Public Health. (18012467)
1928

Genetic Variations for Endemic Goiter

Expression for genes affiliated with Endemic Goiter

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

Sources:
30KEGG
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Pathways related to Endemic Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TPO
2
Hide members
9.1TG, TPO, TSHR

Compounds for genes affiliated with Endemic Goiter

Sources:
45Novoseek, 24HMDB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Endemic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.3TRH
2iodotyrosine45 2411.0TG, TPO
3diiodotyrosine4510.0TG, TPO
4perchlorate4510.0TPO, TG
5carbimazole45 1110.8TSHR, TPO
6gliadin459.8TG, TPO
7chromium459.7TPO
8amino acid459.7TPO, TSHR
9Liothyronine11 2410.6SERPINA7, TPO
10sodium iodide459.5TSHR, TPO, TG
11propylthiouracil45 2 1111.5TG, TPO, TSHR
12ghrp459.4TRH, IGFBP3
13hydrocortisone45 2 60 1112.4TRH, TPO, TG
14amiodarone45 50 29 1112.4TG, TPO, SERPINA7
15isoflavone459.4IGFBP3, TPO
16maltose45 1110.4TSHR, TPO
17pyridostigmine45 1110.4TRH, IGFBP3
18sodium dodecylsulfate459.4SERPINA7, TPO, TG
19asparagine459.3SERPINA7, TSHR, TPO
20sialic acid459.3TG, TSHR, SERPINA7
21fenfluramine29 45 1111.2TRH, IGFBP3
22agarose459.2SERPINA7, TSHR, TPO
23octreotide45 60 29 1112.1TG, TRH, IGFBP3
24prednisolone45 29 1111.1TG, TSHR, IGFBP3
25carbohydrates459.0IGFBP3, TSHR, TG
26125i458.9SERPINA7, TSHR, TPO, TG
27iodide45 249.9TG, TPO, TSHR, SERPINA7
28vitamin a45 11 2410.9TG, SERPINA7, IGFBP3
29ascorbic acid45 249.8TG, TPO, IGFBP3
30polysaccharide458.7IGFBP3, TSHR, TPO, TG
31thymidine45 249.6TG, TSHR, TRH, IGFBP3
32chloramphenicol45 2 1110.6IGFBP3, SERPINA7, TSHR
33creatinine458.5IGFBP3, SERPINA7, TPO, TG
34iodine45 249.4TRH, SERPINA7, TSHR, TPO, TG
35estradiol45 11 2410.4IGFBP3, TRH, SERPINA7, TSHR
36cholesterol45 29 11 2411.3IGFBP3, SERPINA7, TSHR, TPO
37progesterone45 60 29 11 2412.3IGFBP3, TRH, SERPINA7, TSHR
38tyrosine458.2TRH, SERPINA7, TSHR, TPO, TG
39adenylate458.2TG, TPO, TSHR, TRH, IGFBP3
40glutamate458.2IGFBP3, TRH, TSHR, TPO, TG
41alanine458.1TG, TSHR, SERPINA7, IGFBP3
42ribonucleic acid458.1IGFBP3, SERPINA7, TSHR, TPO, TG
43aspartate458.1IGFBP3, SERPINA7, TSHR, TPO, TG
44testosterone45 60 11 2411.1IGFBP3, TRH, SERPINA7, TPO, TG
45estrogen458.0IGFBP3, TRH, SERPINA7, TSHR, TG
46acth458.0IGFBP3, TRH, SERPINA7, TSHR, TPO
47methimazole45 2 119.6TG, TPO, TSHR, SERPINA7, TRH, IGFBP3
48triiodothyronine457.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG
49thyroxine45 248.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG
50arginine457.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG

GO Terms for genes affiliated with Endemic Goiter

Sources:
16Gene Ontology
See all sources

Cellular components related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1TG, SERPINA7, TRH, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2response to corticosterone stimulusGO:0514129.3SERPINA7, TRH
3thyroid hormone generationGO:0065909.3TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet