MCID: END028
MIFTS: 48

Endemic Goiter malady

Endocrine diseases category

Summaries for Endemic Goiter

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34MalaCards
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MalaCards: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Allograft rejection and Insulin secretion. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Endemic Goiter

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

endemic goiter 9 46 63
iodine-deficiency-related goitre, unspecified 9
iodine-deficiency-related goiter, unspecified 9
iodine-deficiency-related endemic goiter 9
iodine-deficiency-related endemic goitre 9
goiter, specified as simple 9
simple goitre 9
simple goiter 9


External Ids:

Disease Ontology9 DOID:13198
NCIt41 C35023
MeSH36 D006043
ICD9CM28 240.0
ICD1026 E01.2

Related Diseases for Endemic Goiter

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18GeneCards, 19GeneDecks
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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.9TSHR, SERPINA7, TG, TPO
2thyroiditis31.4TPO, TG, SERPINA7, TSHR
3thyroid cancer30.7TSHR, TG, TPO
4hypothyroidism30.5TPO, TG, SERPINA7, TSHR
5thyrotoxicosis30.5TSHR, SERPINA7, TG, TPO
6multinodular goiter30.4TSHR, TG, TPO
7follicular thyroid carcinoma30.2TSHR, TG
8autoimmune thyroiditis30.2TG, TPO
9pendred syndrome30.2TG, TPO
10nontoxic goiter30.2TPO, TG, TSHR
11adenoma30.1IGFBP3, TPO, TG, TSHR
12hyperthyroidism30.0TSHR, SERPINA7, TG, TPO
13cerebritis10.3
14hyperparathyroidism10.3
15mutism10.1
16tonsillitis10.1
17chagas disease10.1
18acute thyroiditis10.1
19parathyroid adenoma10.1
20neurologic diseases10.1
21mental retardation10.1
22blindness10.1
23turner syndrome10.1IGFBP3
24pernicious anemia10.0TPO, TG
25plummer's disease10.0TPO, TG
26thyrotropin deficiency, isolated10.0TG, TPO
27pregnancy loss10.0TG, TPO
28struma ovarii10.0TG, TSHR
29premature ovarian failure10.0TPO, IGFBP3
30addison's disease10.0TPO, TG
31li-fraumeni syndrome10.0TPO, IGFBP3
32celiac disease10.0TG, TPO
33precocious puberty10.0TSHR, IGFBP3
34thyroid hormone resistance syndrome10.0SERPINA7, TG
35down syndrome10.0TSHR, TPO
36subacute thyroiditis10.0TPO, TG, TSHR
37toxic diffuse goiter10.0TSHR, TG, TPO
38myxedema10.0TPO, TG, TSHR
39nodular goiter10.0TPO, TG, TSHR
40thyroid cancer, anaplastic10.0TSHR, TG, TPO
41follicular adenoma10.0TPO, TG, TSHR
42papillary carcinoma10.0TSHR, TG, TPO
43papillary thyroid carcinoma10.0TPO, TG, TSHR
44hyperglycemia10.0IGFBP3, TPO
45pre-eclampsia10.0SERPINA7, IGFBP3
46hypersensitivity reaction type ii disease10.0TSHR, TG, TPO
47liver cirrhosis10.0SERPINA7, IGFBP3
48thyroid agenesis10.0TG, SERPINA7, TSHR
49hyperthyroxinemia9.9TSHR, SERPINA7, TPO
50congenital hypothyroidism9.9TSHR, SERPINA7, TG, TPO

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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34MalaCards
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MalaCards organs/tissues related to Endemic Goiter:

34
Thyroid, Testes, Cortex, Bone, Tonsil, Pituitary

Animal Models for Endemic Goiter or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Endemic Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4TSHR, TG, TPO, IGFBP3
2MP:00053798.3TSHR, TG, TPO, IGFBP3
3MP:00053788.1IGFBP3, TPO, TG, TSHR

Publications for Endemic Goiter

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53PubMed
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Articles related to Endemic Goiter:

(show top 50)    (show all 317)
idTitleAuthorsYear
1
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
2
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
5
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
6
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
7
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
8
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
9
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
10
Management of hyperparathyroidism in an endemic goiter area. (9494424)
1998
11
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
12
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
13
Is endemic goiter an autoimmune disease? (7909815)
1994
14
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
15
Measurement of serum TSH level by ultrasensitive method in inhabitants of endemic goiter area supplied with iodized salt for 25 years. (1782815)
1991
16
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
17
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
18
Circadian and seasonal variations in iodine excretion in children with and without endemic goiter. (2799241)
1989
19
Serum thyroglobulin and TSH in a moderate endemic goiter area. (3742838)
1986
20
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
21
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
22
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
23
Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. (6832943)
1983
24
Nutrition and iodine versus genetic factors in endemic goiter. (6619528)
1983
25
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
26
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
27
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
28
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
29
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
30
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
31
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
32
Water-borne goitrogens and their role in the etiology of endemic goiter. (4570428)
1973
33
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
34
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
35
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
36
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
37
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
38
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
SOIL FERTILIZATION WITH COASTAL IODINE SOURCES AS A PROPHYLACTIC MEASURE AGAINST ENDEMIC GOITER. (14185893)
1964
41
THE ECOLOGY OF ENDEMIC GOITER. (14106046)
1964
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
44
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Endemic goiter. (13441193)
1957
47
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome
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Compounds for genes affiliated with Endemic Goiter

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 3BitterDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Endemic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1iodotyrosine46 2510.9TG, TPO
2diiodotyrosine469.9TPO, TG
3perchlorate469.9TG, TPO
4isoflavone469.7TPO, IGFBP3
5gliadin469.7TPO, TG
6carbimazole46 1210.7TSHR, TPO
7chromium469.7TG, TPO
8amino acid469.6TSHR, TPO
9maltose46 1210.5TSHR, TPO
10cardiolipin46 1210.5TG, TPO
11liothyronine52 25 1211.4SERPINA7, TPO
12sodium iodide469.3TSHR, TG, TPO
13propylthiouracil46 3 1211.3TPO, TG, TSHR
14levonorgestrel46 62 30 1212.3IGFBP3, SERPINA7
15prednisolone46 30 1211.3IGFBP3, TG, TSHR
16carbohydrates469.2IGFBP3, TG, TSHR
17ascorbic acid46 2510.2IGFBP3, TPO, TG
18amiodarone46 52 30 1212.1TPO, TG, SERPINA7
19sodium dodecylsulfate469.1SERPINA7, TG, TPO
20vitamin a46 25 1211.0SERPINA7, TG, IGFBP3
21sialic acid469.0TG, SERPINA7, TSHR
22glutamine468.9IGFBP3, TG, TSHR
23asparagine468.9TPO, SERPINA7, TSHR
24agarose468.9TPO, SERPINA7, TSHR
25sodium46 259.9TSHR, TG, TPO
26chloramphenicol46 3 52 1211.8TSHR, SERPINA7, IGFBP3
27polysaccharide468.8TSHR, TG, TPO, IGFBP3
28adenylate468.8IGFBP3, TPO, TG, TSHR
29histidine468.8TSHR, SERPINA7, TPO
30glutamate468.7IGFBP3, TPO, TG, TSHR
31retinoic acid46 259.7IGFBP3, TPO, TG, TSHR
32cysteine468.7IGFBP3, TPO, TG, TSHR
33estradiol46 25 1210.6TSHR, SERPINA7, IGFBP3
34thymidine46 259.6TSHR, TG, IGFBP3
35creatinine468.6SERPINA7, TG, TPO, IGFBP3
36testosterone46 62 25 1211.5SERPINA7, TG, TPO, IGFBP3
37iodine46 259.5TSHR, SERPINA7, TG, TPO
38125i468.5TPO, TG, SERPINA7, TSHR
39iodide46 259.5TSHR, SERPINA7, TG, TPO
40acth468.4TSHR, SERPINA7, TPO, IGFBP3
41alanine468.4IGFBP3, TG, SERPINA7, TSHR
42estrogen468.4IGFBP3, TG, SERPINA7, TSHR
43cholesterol46 30 25 1211.4TSHR, SERPINA7, TPO, IGFBP3
44methimazole46 3 1210.0TSHR, SERPINA7, TG, TPO, IGFBP3
45triiodothyronine468.0IGFBP3, TPO, TG, SERPINA7, TSHR
46thyroxine46 259.0IGFBP3, TPO, TG, SERPINA7, TSHR
47ribonucleic acid468.0IGFBP3, TPO, TG, SERPINA7, TSHR
48aspartate468.0IGFBP3, TPO, TG, SERPINA7, TSHR
49arginine468.0IGFBP3, TPO, TG, SERPINA7, TSHR
50serine468.0IGFBP3, TG, SERPINA7, TSHR

GO Terms for genes affiliated with Endemic Goiter

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17Gene Ontology
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Cellular components related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2SERPINA7, TG, TPO, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.5TG, TPO
2hormone biosynthetic processGO:0424469.2TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet