MCID: END028
MIFTS: 38

Endemic Goiter malady

Endocrine diseases, Metabolic diseases, Cancer diseases categories

Aliases & Classifications for Endemic Goiter

About this section
Sources:
65UMLS, 10Disease Ontology, 47Novoseek, 12DISEASES, 36MeSH, 42NCIt, 59SNOMED-CT, 29ICD9CM, 27ICD10
See all sources

Aliases & Descriptions for Endemic Goiter:

Name: Endemic Goiter 10 47 12 65
Goiter, Multinodular 1, with or Without Sertoli-Leydig Cell Tumors 65
Iodine-Deficiency-Related Goiter, Unspecified 10
Iodine-Deficiency-Related Goitre, Unspecified 10
Iodine-Deficiency-Related Endemic Goiter 10
 
Iodine-Deficiency-Related Endemic Goitre 10
Goiter, Specified As Simple 10
Goiter, Endemic 36
Simple Goitre 10
Simple Goiter 10


Classifications:



External Ids:

Disease Ontology10 DOID:13198
NCIt42 C35023
ICD9CM29 240.0
MeSH36 D006043
ICD1027 E01.2

Summaries for Endemic Goiter

About this section
MalaCards based summary: Endemic Goiter, also known as goiter, multinodular 1, with or without sertoli-leydig cell tumors, is related to thyroiditis and autoimmune thyroiditis. An important gene associated with Endemic Goiter is DICER1 (Dicer 1, Ribonuclease Type III), and among its related pathways are Amine-derived hormones and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are hearing/vestibular/ear and homeostasis/metabolism.

Related Diseases for Endemic Goiter

About this section

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7CALCA, TG
2autoimmune thyroiditis30.4TG, TPO
3pendred syndrome30.1FOXI1, TG, TPO
4goiter11.4
5thyroid cancer10.5
6hypothyroidism10.5
7multinodular goiter10.3
8cerebritis10.3
9hyperparathyroidism10.3
10thyroid ectopia10.2TG, TPO
11colon lymphoma10.2SERPINA7, TPO
12nontoxic goiter10.2
13lumbosacral plexus lesion10.1TG, TPO
14insulin-like growth factor i10.1
15acute thyroiditis10.1
16chagas disease10.1
17tonsillitis10.1
18tracheomalacia10.1
19mutism10.1
20adenoma10.1
21angiosarcoma10.1
22hyperthyroidism10.1
23parathyroid adenoma10.1
24neurologic diseases10.1
25differentiated thyroid carcinoma10.1
26thyroid hemiagenesis10.1
27methemoglobinemia10.1TG, TPO
28neurofibrosarcoma10.1TG, TPO
29glaucoma, primary open angle, juvenile-onset, 210.1TG, TPO
30goiter, multinodular 1, with or without sertoli-leydig cell tumors10.1
31adult central nervous system germinoma10.1TG, TSHR
32iatrogenic or traumatic pituitary deficiency10.1TG, TSHR
33subcutaneous mycosis10.1TG, TSHR
34intraneural perineurioma10.1CALCA, TG
35selective iga deficiency disease10.0CALCA, TG
36riedel's fibrosing thyroiditis10.0CALCA, TG
37uterine corpus adenofibroma10.0CALCA, TG
38rhabdomyosarcoma, embryonal, 210.0DICER1, TG, TPO
39hypoaldosteronism10.0CALCA, TG
40gonococcal iridocyclitis10.0TG, TSHR
41pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.0CALCA, TPO
42vulvar apocrine adenocarcinoma10.0CALCA, TG
43neonatal meningitis10.0TG, TPO, TSHR
44radial nerve lesion10.0FOXI1, SERPINA7, TG
45autoimmune disease of gastrointestinal tract10.0TG, TPO, TSHR
46hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0SERPINA7, TG, TSHR
47familial abdominal aortic aneurysm10.0TG, TPO, TSHR
48hypersensitivity reaction type iii disease9.9TG, TPO, TSHR
49mononeuritis of upper limb9.9CALCA, TG, TPO
50junctional epidermolysis bullosa9.9CALCA, TG

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

About this section

Drugs & Therapeutics for Endemic Goiter

About this section

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Iodine4597553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
2cadexomer iodine425

Interventional clinical trials:

idNameStatusNCT IDPhase
1Maternal Iodine Supplementation and Effects on Thyroid Function and Child DevelopmentActive, not recruitingNCT00791466

Search NIH Clinical Center for Endemic Goiter


Cochrane evidence based reviews: Goiter, Endemic

Genetic Tests for Endemic Goiter

About this section

Anatomical Context for Endemic Goiter

About this section

MalaCards organs/tissues related to Endemic Goiter:

33
Thyroid, Testes, Cortex, Pituitary, Tonsil, Bone

Animal Models for Endemic Goiter or affiliated genes

About this section

MGI Mouse Phenotypes related to Endemic Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.5CALCA, FOXI1, TPO, TSHR
2MP:00053767.7CALCA, DICER1, FOXI1, TG, TPO, TSHR

Publications for Endemic Goiter

About this section

Articles related to Endemic Goiter:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
2
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
5
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
6
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
7
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
8
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
9
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
10
Elevated anti-galactosyl antibody titers in endemic goiter. (10365681)
1999
11
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
12
Is residence in areas of endemic goiter a risk factor for thyroid cancer? (7768633)
1995
13
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
14
Is endemic goiter an autoimmune disease? (7909815)
1994
15
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
16
Measurement of serum TSH level by ultrasensitive method in inhabitants of endemic goiter area supplied with iodized salt for 25 years. (1782815)
1991
17
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
18
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
19
Serum thyroglobulin and TSH in a moderate endemic goiter area. (3742838)
1986
20
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
21
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
22
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
23
Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. (6832943)
1983
24
Nutrition and iodine versus genetic factors in endemic goiter. (6619528)
1983
25
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
26
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
27
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
28
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
29
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
30
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
31
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
32
Water-borne goitrogens and their role in the etiology of endemic goiter. (4570428)
1973
33
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
34
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
35
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
36
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
37
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
38
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
SOIL FERTILIZATION WITH COASTAL IODINE SOURCES AS A PROPHYLACTIC MEASURE AGAINST ENDEMIC GOITER. (14185893)
1964
41
THE ECOLOGY OF ENDEMIC GOITER. (14106046)
1964
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
44
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Endemic goiter. (13441193)
1957
47
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Endemic Goiter

About this section

Clinvar genetic disease variations for Endemic Goiter:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DICER1DICER1, SER1826TERsingle nucleotide variantPathogenic

Expression for genes affiliated with Endemic Goiter

About this section
Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

About this section

GO Terms for genes affiliated with Endemic Goiter

About this section

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1inner ear receptor cell developmentGO:006011910.1DICER1, TSHR
2regulation of myelinationGO:003164110.0DICER1, TG
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.6CALCA, TSHR
4activation of adenylate cyclase activityGO:00071909.5CALCA, TSHR
5hormone biosynthetic processGO:00424469.4TG, TPO
6response to vitamin AGO:00331899.2SERPINA7, TSHB
7cell-cell signalingGO:00072678.6CALCA, TSHB, TSHR

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.6CALCA, TG, TSHB

Sources for Endemic Goiter

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet