MCID: END028
MIFTS: 36

Endemic Goiter malady

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

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Aliases & Descriptions for Endemic Goiter:

Name: Endemic Goiter 11 13 48 66
Iodine-Deficiency-Related Goitre, Unspecified 11
Iodine-Deficiency-Related Goiter, Unspecified 11
Iodine-Deficiency-Related Endemic Goiter 11
Iodine-Deficiency-Related Endemic Goitre 11
 
Goiter, Specified As Simple 11
Euthyroid Goiter 66
Goiter, Endemic 37
Simple Goitre 11
Simple Goiter 11

Classifications:



External Ids:

Disease Ontology11 DOID:13198
ICD1028 E01.0, E01.2
ICD9CM30 240.0
MeSH37 D006043
NCIt43 C35023

Summaries for Endemic Goiter

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MalaCards based summary: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to acute thyroiditis and nontoxic goiter. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Amine-derived hormones. Affiliated tissues include thyroid, testes and cortex.

Related Diseases for Endemic Goiter

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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1acute thyroiditis29.6CALCA, TG
2nontoxic goiter11.2
3goiter, multinodular 1, with or without sertoli-leydig cell tumors11.1
4goiter11.0
5thyroiditis10.7
6iatrogenic or traumatic pituitary deficiency10.4TG, TPO
7ovarian endometrioid cystadenoma10.4TG, TPO
8rhabdomyosarcoma, embryonal, 210.4TG, TPO
9crohn's disease of the esophagus10.4TG, TPO
10peripheral scars of retina10.3TG, TPO
11chronic frontal sinusitis10.3TG, TPO
12hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.3SERPINA7, TG
13presbyopia10.3SERPINA7, TG
14lung occult adenocarcinoma10.2SERPINA7, TG
15dysautonomia, familial10.2TG, TPO
16thyroid cancer10.2
17hypothyroidism10.1
18blood group incompatibility10.1TG, TPO
19hypertelorism, preauricular sinus, punctal pits, and deafness10.0SERPINA7, TG, TPO
20atrial standstill10.0TG, TPO
21cd3zeta deficiency10.0SERPINA7, TG, TPO
22deep angioma10.0CALCA, TG
23pleomorphic adenoma9.9CALCA, TG
24multinodular goiter9.9
25hyperparathyroidism9.9
26cerebritis9.9
27deafness, autosomal recessive 4, with enlarged vestibular aqueduct9.9FOXI1, TG, TPO
28mixed endometrial stromal and smooth muscle tumor9.9CALCA, TG
29tinea corporis9.9FOXI1, SERPINA7, TG
30norwegian scabies9.9CALCA, TG
31hypocomplementemic urticarial vasculitis syndrome9.9CALCA, TG
32meckel's diverticulum9.9CALCA, TPO
33bone lymphoma9.8CALCA, TG
34hypothryoidism, congenital, nongoitrous 49.8TG, TPO, TSHB
35substernal goiter9.8CALCA, TG
36primary bacterial infectious disease9.8TG, TPO, TSHB
37epididymal neoplasm9.8CALCA, TG
38insulin-like growth factor i9.8
39angiosarcoma9.8
40tracheomalacia9.8
41tonsillitis9.8
42chagas disease9.8
43mutism9.8
44adenoma9.8
45parathyroid adenoma9.8
46hyperthyroidism9.8
47differentiated thyroid carcinoma9.8
48intermittent proptosis9.7TG, TPO
49dysgraphia9.7CALCA, TG
50richter's syndrome9.7CALCA, TG

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Iodine5167553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
2cadexomer iodine484

Interventional clinical trials:

idNameStatusNCT IDPhase
1Maternal Iodine Supplementation and Effects on Thyroid Function and Child DevelopmentCompletedNCT00791466
2Exploration of Effects of Excessive Iodine on Children and Tolerable Upper Intake Level of Iodine for ChildrenCompletedNCT02915536

Search NIH Clinical Center for Endemic Goiter


Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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MalaCards organs/tissues related to Endemic Goiter:

34
Thyroid, Testes, Cortex, Pituitary, Tonsil, Bone

Animal Models for Endemic Goiter or affiliated genes

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Publications for Endemic Goiter

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Articles related to Endemic Goiter:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. (26949559)
2016
2
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
5
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
6
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
7
Management of hyperparathyroidism in an endemic goiter area. (9494424)
1998
8
Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. (9398711)
1997
9
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
10
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
11
Is endemic goiter an autoimmune disease? (7909815)
1994
12
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
13
Endemic goiter in the Lemanak and Ai river villages of Sarawak. (7777929)
1994
14
Clinical, laboratory and immunologic effects of the treatment of endemic goiter with T4, T3 and KI. (1724914)
1990
15
Thyroid growth promoting serum-IgG in endemic goiter. (1975149)
1990
16
Endemic goiter and iodine deficiency in Yugoslavia. (2768765)
1989
17
Management of goiter and thyroid nodules in an area of endemic goiter. (3551146)
1987
18
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
19
For many, endemic goiter remains a baffling problem. (3974064)
1985
20
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
21
Some aspects concerning taste sensitivity to PTC and dermatoglyphics in children from endemic goiter areas. (7361069)
1980
22
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
23
Evidence that cassava ingestion increases thiocyanate formation: a possible etiologic factor in endemic goiter. (755045)
1978
24
Similar serum IgM concentrations in Greek endemic goiter and control populations: failure to confirm previous experience. (932180)
1976
25
Thyroxine (T4) and triiodothyronine (T3): effects of iodine on the serum concentrations and disposal rates in subjects from an endemic goiter area. (4815170)
1974
26
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
27
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
28
Thyroid cancer, Quervain's thyroiditis and Hashimoto's disease in an endemic goiter Andean area. (4523785)
1973
29
Endemic goiter in Southeast Asia. New clothes on an old body. (4265088)
1973
30
Goitrogenic action of cyanogenic glucosides present in cassava: a possible etiologic factor of endemic goiter in the Idjwi island. (4523769)
1973
31
Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter. (5071345)
1972
32
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
33
Prophylaxis and treatment of endemic goiter with iodized oil in rural Ecuador and Peru. (4312017)
1969
34
Endemic goiter in the Cauca Valley. I. Results and limitations of twelve years of iodine prophylaxis. (5699948)
1968
35
A study on the endemic goiter in Madjalengka district of the Republic of Indonesia. (6077200)
1967
36
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
37
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
38
Thyroid carcinoma in an endemic goiter area, Cali, Colombia. (5900688)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
RADIOIODINE STUDY OF THYROID FUNCTION IN THYROTOXICOSIS AND ENDEMIC GOITER. (14060292)
1963
41
Research on iodine metabolism in endemic goiter in Piedmont. (14023255)
1963
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Interrelationship of endemic goiter and Chagas' disease. (14018685)
1962
44
Endemic goiter. II. Pathophysiology and pathology. (14471216)
1962
45
Endemic goiter in Costa Rican school children. (13362660)
1956
46
Endemic goiter in Latin America. (13134444)
1954
47
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
48
Endemic goiter and cretinism. (18117366)
1949
49
ENDEMIC GOITER IN JAPAN. (17857750)
1941
50
Endemic Goiter and Its Relation to Iodine Content of Food. (18012855)
1929

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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GO Terms for genes affiliated with Endemic Goiter

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Cellular components related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.4CALCA, SERPINA7, TG, TPO

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.6TG, TPO
2thyroid hormone generationGO:00065909.3TG, TPO

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.6CALCA, TG, TSHB

Sources for Endemic Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet