MCID: END028
MIFTS: 38

Endemic Goiter malady

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

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Aliases & Descriptions for Endemic Goiter:

Name: Endemic Goiter 10 47 12 65
Iodine-Deficiency-Related Goitre, Unspecified 10
Iodine-Deficiency-Related Goiter, Unspecified 10
Iodine-Deficiency-Related Endemic Goiter 10
Iodine-Deficiency-Related Endemic Goitre 10
 
Goiter, Specified As Simple 10
Euthyroid Goiter 65
Goiter, Endemic 36
Simple Goitre 10
Simple Goiter 10

Classifications:



External Ids:

Disease Ontology10 DOID:13198
ICD1027 E01.0, E01.2
ICD9CM29 240.0
MeSH36 D006043
NCIt42 C35023
UMLS65 C0018022, C0302859

Summaries for Endemic Goiter

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MalaCards based summary: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to thyroiditis and nontoxic goiter. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways are Amine-derived hormones and Hormone ligand-binding receptors. Affiliated tissues include lung, breast and brain.

Related Diseases for Endemic Goiter

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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 288)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.0TG, TPO, TSHR
2nontoxic goiter11.6
3goiter, multinodular 1, with or without sertoli-leydig cell tumors11.5
4endotheliitis10.3
5breast cancer10.3
6autoimmune thyroiditis10.3TG, TPO
7thyroid ectopia10.3TG, TPO
8neonatal meningitis10.3TG, TPO
9arthritis10.3
10tuberculosis10.3
11solar retinopathy10.2TG, TPO
12euthyroid sick syndrome10.2SERPINA7, TPO
13setariasis10.2TG, TPO
14chronic inflammatory demyelinating polyradiculoneuropathy10.2TG, TSHR
15iatrogenic or traumatic pituitary deficiency10.2TG, TSHR
16megaloblastic anemia10.2TG, TPO
17laryngeal mucoepidermoid carcinoma10.2CALCA, TG
18perivascular epithelioid cell tumor10.2TG, TSHR
19rheumatoid arthritis10.2
20prostate cancer10.2
21prostatitis10.2
22dermatitis10.2
23neuronitis10.2
24muscular dystrophy10.2
25hypoxia10.2
26skin angiosarcoma10.2CALCA, TG
27scabies10.2CALCA, TG
28corneal ectasia10.1CALCA, TG
29glaucoma, primary open angle, juvenile-onset, 210.1TG, TPO
30chest wall lymphoma10.1CALCA, TG
31hypoaldosteronism10.1CALCA, TG
32schizophrenia10.1
33neuroblastoma10.1
34hiv-110.1
35hepatocellular carcinoma10.1
36duchenne muscular dystrophy10.1
37fetal alcohol syndrome10.1
38microcephaly10.1
39antisocial personality disorder10.1
40leiomyoma10.1
41kwashiorkor10.1
42personality disorder10.1
43melanoma10.1
44leptospirosis10.1
45hemangiopericytoma10.1
46adenocarcinoma10.1
47gingival overgrowth10.1
48gingivitis10.1
49pancreatitis10.1
50acute disseminated encephalomyelitis10.1

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Micronutrients3901
2Trace Elements3900
3
Iodine4947553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
4cadexomer iodine456
5Anti-Infective Agents, Local984
6Anti-Infective Agents17220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Maternal Iodine Supplementation and Effects on Thyroid Function and Child DevelopmentActive, not recruitingNCT00791466

Search NIH Clinical Center for Endemic Goiter


Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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MalaCards organs/tissues related to Endemic Goiter:

33
Lung, Breast, Brain, Thyroid, Testes, T cells, Endothelial

Animal Models for Endemic Goiter or affiliated genes

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Publications for Endemic Goiter

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Articles related to Endemic Goiter:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Transmembrane protein TMEM170A is a novel regulator of ER and NE morphogenesis in human cells. (26906412)
2016
2
A slowly progressive mitochondrial encephalomyopathy widens the spectrum of AIFM1 disorders. (25934856)
2015
3
MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRI^. (25736597)
2015
4
Donor-specific antibodies, C4d and their relationship with the prognosis of transplant glomerulopathy. (25073036)
2015
5
Patients with polymyalgia rheumatica had a 2.6-fold increased risk for vascular events at a median 7.8 y. (25599360)
2015
6
Exercise Improves Mood State in Normobaric Hypoxia. (26564763)
2015
7
The frequency of presentation and clinico-pathological characteristics of symptomatic versus screen detected ductal carcinoma in situ of the breast. (24433818)
2014
8
Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations. (23602715)
2013
9
Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype. (23525328)
2013
10
Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer. (23981771)
2013
11
Pro- or anti-inflammatory role of apolipoprotein A-1 in high-density lipoproteins? (23740387)
2013
12
Peripheral neuropathy after burn injury. (23436672)
2013
13
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas. (23756599)
2013
14
Neuroendocrine tumor of the cystic duct. (23082709)
2012
15
Human mRNA response to exercise and temperature. (22113536)
2012
16
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: Suxamethonium (succinylcholine) for RSI and intubation in head injury. (22635391)
2012
17
Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication. (23037625)
2012
18
First-trimester ultrasonographic diagnosis of Langer mesomelic dysplasia in a previously affected family. (21692083)
2011
19
Clinical features of lupus cystitis complicated with hydroureteronephrosis in a Chinese population. (21239742)
2011
20
Early predictive biomarkers for lesion after transient cerebral ischemia. (21293024)
2011
21
A novel duplication at the putative DNA polymerase alpha arrest site and a founder mutation in Chinese in the IVD gene underlie isovaleric acidaemia. (20519759)
2010
22
Short stature, severe aortic root dilation, skin hyperextensibility, extreme joint laxity and craniofacial dysmorphic features: a probable new syndrome. (20308875)
2010
23
Review of meningococcal infection in children at a United Kingdom hospital. (19388559)
2009
24
Aquaporin 1 expression in invasive breast carcinomas]. (18841368)
2008
25
Rheumatological manifestations in patients with melioidosis. (19058601)
2008
26
High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. (17868414)
2007
27
Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. (17634537)
2007
28
Median rhomboid glossitis. (17990677)
2007
29
Cell mimetic lateral stabilization of outer cell mimetic bilayer on polymer surfaces by peptide bonding and their blood compatibility. (16758449)
2006
30
Identifying breast cancer patients most likely to benefit from aromatase inhibitor therapy after adjuvant radiation and tamoxifen. (17061250)
2006
31
Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. (15931266)
2005
32
Changes in serum interleukin-6 and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome and their responses to simvastatin. (15799170)
2004
33
Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain. (15163303)
2004
34
Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells. (15062979)
2004
35
Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism. (12730033)
2003
36
Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease. (12699957)
2003
37
Choristoma of the middle ear: a component of a new syndrome? (11347640)
2001
38
Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins. (11514569)
2001
39
Insulin resistance and vascular function]. (10707556)
2000
40
The maximal tolerable intravenous dosage of pentoxifylline in AIDS patients does not inhibit lipopolysaccharide-stimulated tumor necrosis factor alpha production. (9519890)
1998
41
Free radicals derived from oxygen, and medicine. (8004489)
1993
42
Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. (1592292)
1992
43
Changes in PTCA. A model of ischemia in humans]. (1830715)
1991
44
A family of homozygous familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity. (2360880)
1990
45
Porphyria cutanea tarda resulting from primary hepatocellular carcinoma. (2850121)
1988
46
Steatocystoma multiplex. Report of a florid case and a review. (434851)
1979
47
A possible relationship between acute necrotizing ulcerative gingivitis and infectious mononucleosis. (5288705)
1971
48
Alcoholic cardiomyopathy. (14447338)
1961
49
Cervicitis. (15397631)
1949
50
Placenta accreta in syphilis. (18141202)
1949

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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GO Terms for genes affiliated with Endemic Goiter

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Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.8TG, TPO
2activation of adenylate cyclase activityGO:00071909.5CALCA, TSHR
3thyroid hormone generationGO:00065909.5TG, TPO
4cell-cell signalingGO:00072678.8CALCA, TSHB, TSHR

Sources for Endemic Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet