MCID: END028
MIFTS: 48

Endemic Goiter malady

Endocrine diseases category
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Summaries for Endemic Goiter

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33MalaCards
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MalaCards: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Allograft rejection and Insulin secretion. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Endemic Goiter

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

endemic goiter 8 45 62
iodine-deficiency-related goitre, unspecified 8
iodine-deficiency-related goiter, unspecified 8
iodine-deficiency-related endemic goiter 8
iodine-deficiency-related endemic goitre 8
goiter, specified as simple 8
simple goitre 8
simple goiter 8


External Ids:

Disease Ontology8 DOID:13198
NCIt40 C35023
MeSH35 D006043
ICD9CM27 240.0
ICD1025 E01.2

Related Diseases for Endemic Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.9TSHR, SERPINA7, TG, TPO
2thyroiditis31.4TPO, TG, SERPINA7, TSHR
3thyroid cancer30.7TSHR, TG, TPO
4hypothyroidism30.5TPO, TG, SERPINA7, TSHR
5thyrotoxicosis30.5TSHR, SERPINA7, TG, TPO
6multinodular goiter30.4TSHR, TG, TPO
7follicular thyroid carcinoma30.2TSHR, TG
8autoimmune thyroiditis30.2TG, TPO
9pendred syndrome30.2TG, TPO
10nontoxic goiter30.2TPO, TG, TSHR
11adenoma30.1IGFBP3, TPO, TG, TSHR
12hyperthyroidism30.0TSHR, SERPINA7, TG, TPO
13cerebritis10.3
14hyperparathyroidism10.3
15mutism10.1
16tonsillitis10.1
17chagas disease10.1
18acute thyroiditis10.1
19parathyroid adenoma10.1
20neurologic diseases10.1
21mental retardation10.1
22blindness10.1
23turner syndrome10.1IGFBP3
24pernicious anemia10.0TPO, TG
25plummer's disease10.0TPO, TG
26thyrotropin deficiency, isolated10.0TG, TPO
27pregnancy loss10.0TG, TPO
28struma ovarii10.0TG, TSHR
29premature ovarian failure10.0TPO, IGFBP3
30addison's disease10.0TPO, TG
31li-fraumeni syndrome10.0TPO, IGFBP3
32celiac disease10.0TG, TPO
33precocious puberty10.0TSHR, IGFBP3
34thyroid hormone resistance syndrome10.0SERPINA7, TG
35down syndrome10.0TSHR, TPO
36subacute thyroiditis10.0TPO, TG, TSHR
37toxic diffuse goiter10.0TSHR, TG, TPO
38myxedema10.0TPO, TG, TSHR
39nodular goiter10.0TPO, TG, TSHR
40thyroid cancer, anaplastic10.0TSHR, TG, TPO
41follicular adenoma10.0TPO, TG, TSHR
42papillary carcinoma10.0TSHR, TG, TPO
43papillary thyroid carcinoma10.0TPO, TG, TSHR
44hyperglycemia10.0IGFBP3, TPO
45pre-eclampsia10.0SERPINA7, IGFBP3
46hypersensitivity reaction type ii disease10.0TSHR, TG, TPO
47liver cirrhosis10.0SERPINA7, IGFBP3
48thyroid agenesis10.0TG, SERPINA7, TSHR
49hyperthyroxinemia9.9TSHR, SERPINA7, TPO
50congenital hypothyroidism9.9TSHR, SERPINA7, TG, TPO

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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33MalaCards
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MalaCards organs/tissues related to Endemic Goiter:

33
Thyroid, Testes, Cortex, Bone, Tonsil, Pituitary

Animal Models for Endemic Goiter or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Endemic Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4TSHR, TG, TPO, IGFBP3
2MP:00053798.3TSHR, TG, TPO, IGFBP3
3MP:00053788.1IGFBP3, TPO, TG, TSHR

Publications for Endemic Goiter

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52PubMed
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Articles related to Endemic Goiter:

(show top 50)    (show all 317)
idTitleAuthorsYear
1
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
2
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
5
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
6
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
7
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
8
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
9
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
10
Management of hyperparathyroidism in an endemic goiter area. (9494424)
1998
11
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
12
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
13
Is endemic goiter an autoimmune disease? (7909815)
1994
14
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
15
Measurement of serum TSH level by ultrasensitive method in inhabitants of endemic goiter area supplied with iodized salt for 25 years. (1782815)
1991
16
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
17
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
18
Circadian and seasonal variations in iodine excretion in children with and without endemic goiter. (2799241)
1989
19
Serum thyroglobulin and TSH in a moderate endemic goiter area. (3742838)
1986
20
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
21
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
22
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
23
Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. (6832943)
1983
24
Nutrition and iodine versus genetic factors in endemic goiter. (6619528)
1983
25
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
26
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
27
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
28
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
29
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
30
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
31
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
32
Water-borne goitrogens and their role in the etiology of endemic goiter. (4570428)
1973
33
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
34
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
35
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
36
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
37
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
38
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
SOIL FERTILIZATION WITH COASTAL IODINE SOURCES AS A PROPHYLACTIC MEASURE AGAINST ENDEMIC GOITER. (14185893)
1964
41
THE ECOLOGY OF ENDEMIC GOITER. (14106046)
1964
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
44
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Endemic goiter. (13441193)
1957
47
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Endemic Goiter

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 3BitterDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Endemic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2410.9TG, TPO
2diiodotyrosine459.9TPO, TG
3perchlorate459.9TG, TPO
4isoflavone459.7TPO, IGFBP3
5gliadin459.7TPO, TG
6carbimazole45 1110.7TSHR, TPO
7chromium459.7TG, TPO
8amino acid459.6TSHR, TPO
9maltose45 1110.5TSHR, TPO
10cardiolipin45 1110.5TG, TPO
11liothyronine51 24 1111.4SERPINA7, TPO
12sodium iodide459.3TSHR, TG, TPO
13propylthiouracil45 3 1111.3TPO, TG, TSHR
14levonorgestrel45 61 29 1112.3IGFBP3, SERPINA7
15prednisolone45 29 1111.3IGFBP3, TG, TSHR
16carbohydrates459.2IGFBP3, TG, TSHR
17ascorbic acid45 2410.2IGFBP3, TPO, TG
18amiodarone45 51 29 1112.1TPO, TG, SERPINA7
19sodium dodecylsulfate459.1SERPINA7, TG, TPO
20vitamin a45 24 1111.0SERPINA7, TG, IGFBP3
21sialic acid459.0TG, SERPINA7, TSHR
22glutamine458.9IGFBP3, TG, TSHR
23asparagine458.9TPO, SERPINA7, TSHR
24agarose458.9TPO, SERPINA7, TSHR
25sodium45 249.9TSHR, TG, TPO
26chloramphenicol45 3 51 1111.8TSHR, SERPINA7, IGFBP3
27polysaccharide458.8TSHR, TG, TPO, IGFBP3
28adenylate458.8IGFBP3, TPO, TG, TSHR
29histidine458.8TSHR, SERPINA7, TPO
30glutamate458.7IGFBP3, TPO, TG, TSHR
31retinoic acid45 249.7IGFBP3, TPO, TG, TSHR
32cysteine458.7IGFBP3, TPO, TG, TSHR
33estradiol45 24 1110.6TSHR, SERPINA7, IGFBP3
34thymidine45 249.6TSHR, TG, IGFBP3
35creatinine458.6SERPINA7, TG, TPO, IGFBP3
36testosterone45 61 24 1111.5SERPINA7, TG, TPO, IGFBP3
37iodine45 249.5TSHR, SERPINA7, TG, TPO
38125i458.5TPO, TG, SERPINA7, TSHR
39iodide45 249.5TSHR, SERPINA7, TG, TPO
40acth458.4TSHR, SERPINA7, TPO, IGFBP3
41alanine458.4IGFBP3, TG, SERPINA7, TSHR
42estrogen458.4IGFBP3, TG, SERPINA7, TSHR
43cholesterol45 29 24 1111.4TSHR, SERPINA7, TPO, IGFBP3
44methimazole45 3 1110.0TSHR, SERPINA7, TG, TPO, IGFBP3
45triiodothyronine458.0IGFBP3, TPO, TG, SERPINA7, TSHR
46thyroxine45 249.0IGFBP3, TPO, TG, SERPINA7, TSHR
47ribonucleic acid458.0IGFBP3, TPO, TG, SERPINA7, TSHR
48aspartate458.0IGFBP3, TPO, TG, SERPINA7, TSHR
49arginine458.0IGFBP3, TPO, TG, SERPINA7, TSHR
50serine458.0IGFBP3, TG, SERPINA7, TSHR

GO Terms for genes affiliated with Endemic Goiter

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16Gene Ontology
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Cellular components related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2SERPINA7, TG, TPO, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.5TG, TPO
2hormone biosynthetic processGO:0424469.2TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet