MCID: END028
MIFTS: 41

Endemic Goiter malady

Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Endemic Goiter

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Sources:
60UMLS, 9Disease Ontology, 43Novoseek, 55SNOMED-CT, 38NCIt, 33MeSH, 27ICD9CM, 25ICD10
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Endemic Goiter, Aliases & Descriptions:

Name: Endemic Goiter 9 43 60
Goiter, Multinodular 1, with or Without Sertoli-Leydig Cell Tumors 60
Iodine-Deficiency-Related Goiter, Unspecified 9
Iodine-Deficiency-Related Goitre, Unspecified 9
Iodine-Deficiency-Related Endemic Goitre 9
 
Iodine-Deficiency-Related Endemic Goiter 9
Goiter, Specified As Simple 9
Simple Goitre 9
Simple Goiter 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:13198
NCIt38 C35023
MeSH33 D006043
ICD9CM27 240.0
ICD1025 E01.2

Summaries for Endemic Goiter

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MalaCards based summary: Endemic Goiter, also known as goiter, multinodular 1, with or without sertoli-leydig cell tumors, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Allograft rejection and Insulin secretion. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Related Diseases for Endemic Goiter

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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.5TSHR, SERPINA7, TG, TPO
2thyroiditis31.0TPO, TG, SERPINA7, TSHR
3thyroid cancer30.6TSHR, TG, TPO
4autoimmune thyroiditis30.4TG, TPO
5pendred syndrome30.4TG, TPO
6multinodular goiter30.3TSHR, TG, TPO
7nontoxic goiter30.1TPO, TG, TSHR
8hypothyroidism30.1TPO, TG, SERPINA7, TSHR
9thyrotoxicosis30.0TSHR, SERPINA7, TG, TPO
10adenoma29.7IGFBP3, TPO, TG, TSHR
11hyperthyroidism29.6TSHR, SERPINA7, TG, TPO
12turner syndrome10.3IGFBP3
13cerebritis10.3
14hyperparathyroidism10.3
15goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2TPO, TG
16pernicious anemia10.2TPO, TG
17plummer's disease10.2TPO, TG
18hypothryoidism, congenital, nongoitrous 410.2TG, TPO
19struma ovarii10.1TG, TSHR
20premature ovarian failure10.1TPO, IGFBP3
21insulin-like growth factor i10.1
22mutism10.1
23tonsillitis10.1
24chagas disease10.1
25tracheomalacia10.1
26acute thyroiditis10.1
27angiosarcoma10.1
28parathyroid adenoma10.1
29neurologic diseases10.1
30mental retardation10.1
31blindness10.1
32thyroid hemiagenesis10.1
33thyroid carcinoma, follicular10.1TSHR, TG
34addison's disease10.1TPO, TG
35li-fraumeni syndrome10.1TPO, IGFBP3
36celiac disease10.1TG, TPO
37precocious puberty10.1TSHR, IGFBP3
38thyroid hormone resistance10.0SERPINA7, TG
39pregnancy loss, recurrent 110.0SERPINA7, TPO
40down syndrome10.0TSHR, TPO
41subacute thyroiditis10.0TPO, TG, TSHR
42toxic diffuse goiter9.9TSHR, TG, TPO
43myxedema9.9TPO, TG, TSHR
44nodular goiter9.9TPO, TG, TSHR
45thyroid cancer, anaplastic9.9TSHR, TG, TPO
46follicular adenoma9.9TPO, TG, TSHR
47papillary carcinoma9.9TSHR, TG, TPO
48nutritional deficiency disease9.9IGFBP3, SERPINA7
49thyroid carcinoma, papillary9.9TPO, TG, TSHR
50hyperglycemia9.9IGFBP3, TPO

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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Drug clinical trials:

Search ClinicalTrials for Endemic Goiter

Search NIH Clinical Center for Endemic Goiter

Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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MalaCards organs/tissues related to Endemic Goiter:

31
Thyroid, Testes, Cortex, Bone, Tonsil, Pituitary

Animal Models for Endemic Goiter or affiliated genes

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MGI Mouse Phenotypes related to Endemic Goiter:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4TSHR, TG, TPO, IGFBP3
2MP:00053798.3TSHR, TG, TPO, IGFBP3
3MP:00053788.1IGFBP3, TPO, TG, TSHR

Publications for Endemic Goiter

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Articles related to Endemic Goiter:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
2
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
5
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
6
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
7
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
8
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
9
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
10
Elevated anti-galactosyl antibody titers in endemic goiter. (10365681)
1999
11
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
12
Is residence in areas of endemic goiter a risk factor for thyroid cancer? (7768633)
1995
13
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
14
Is endemic goiter an autoimmune disease? (7909815)
1994
15
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
16
Measurement of serum TSH level by ultrasensitive method in inhabitants of endemic goiter area supplied with iodized salt for 25 years. (1782815)
1991
17
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
18
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
19
Serum thyroglobulin and TSH in a moderate endemic goiter area. (3742838)
1986
20
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
21
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
22
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
23
Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. (6832943)
1983
24
Nutrition and iodine versus genetic factors in endemic goiter. (6619528)
1983
25
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
26
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
27
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
28
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
29
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
30
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
31
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
32
Water-borne goitrogens and their role in the etiology of endemic goiter. (4570428)
1973
33
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
34
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
35
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
36
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
37
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
38
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
SOIL FERTILIZATION WITH COASTAL IODINE SOURCES AS A PROPHYLACTIC MEASURE AGAINST ENDEMIC GOITER. (14185893)
1964
41
THE ECOLOGY OF ENDEMIC GOITER. (14106046)
1964
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
44
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Endemic goiter. (13441193)
1957
47
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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Compounds for genes affiliated with Endemic Goiter

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Compounds related to Endemic Goiter according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1iodotyrosine43 2410.9TG, TPO
2diiodotyrosine439.9TPO, TG
3perchlorate439.9TG, TPO
4isoflavone439.7TPO, IGFBP3
5gliadin439.7TPO, TG
6carbimazole43 1210.7TSHR, TPO
7chromium439.7TG, TPO
8amino acid439.6TSHR, TPO
9maltose43 1210.5TSHR, TPO
10cardiolipin43 1210.5TG, TPO
11liothyronine49 24 1211.4SERPINA7, TPO
12sodium iodide439.3TSHR, TG, TPO
13propylthiouracil43 2 1211.3TPO, TG, TSHR
14levonorgestrel43 59 28 1212.3IGFBP3, SERPINA7
15prednisolone43 28 1211.3IGFBP3, TG, TSHR
16carbohydrates439.2IGFBP3, TG, TSHR
17ascorbic acid43 2410.2IGFBP3, TPO, TG
18amiodarone43 49 28 1212.1TPO, TG, SERPINA7
19sodium dodecylsulfate439.1SERPINA7, TG, TPO
20vitamin a43 24 1211.0SERPINA7, TG, IGFBP3
21sialic acid439.0TG, SERPINA7, TSHR
22glutamine438.9IGFBP3, TG, TSHR
23asparagine438.9TPO, SERPINA7, TSHR
24agarose438.9TPO, SERPINA7, TSHR
25sodium43 249.9TSHR, TG, TPO
26chloramphenicol43 2 49 1211.8TSHR, SERPINA7, IGFBP3
27polysaccharide438.8TSHR, TG, TPO, IGFBP3
28adenylate438.8IGFBP3, TPO, TG, TSHR
29histidine438.8TSHR, SERPINA7, TPO
30glutamate438.7IGFBP3, TPO, TG, TSHR
31retinoic acid43 249.7IGFBP3, TPO, TG, TSHR
32cysteine438.7IGFBP3, TPO, TG, TSHR
33estradiol43 24 1210.6TSHR, SERPINA7, IGFBP3
34thymidine43 249.6TSHR, TG, IGFBP3
35creatinine438.6SERPINA7, TG, TPO, IGFBP3
36testosterone43 59 24 1211.5SERPINA7, TG, TPO, IGFBP3
37iodine43 249.5TSHR, SERPINA7, TG, TPO
38125i438.5TPO, TG, SERPINA7, TSHR
39iodide43 249.5TSHR, SERPINA7, TG, TPO
40acth438.4TSHR, SERPINA7, TPO, IGFBP3
41alanine438.4IGFBP3, TG, SERPINA7, TSHR
42estrogen438.4IGFBP3, TG, SERPINA7, TSHR
43cholesterol43 28 24 1211.4TSHR, SERPINA7, TPO, IGFBP3
44methimazole43 2 1210.0TSHR, SERPINA7, TG, TPO, IGFBP3
45triiodothyronine438.0IGFBP3, TPO, TG, SERPINA7, TSHR
46thyroxine43 249.0IGFBP3, TPO, TG, SERPINA7, TSHR
47ribonucleic acid438.0IGFBP3, TPO, TG, SERPINA7, TSHR
48aspartate438.0IGFBP3, TPO, TG, SERPINA7, TSHR
49arginine438.0IGFBP3, TPO, TG, SERPINA7, TSHR
50serine438.0IGFBP3, TG, SERPINA7, TSHR

GO Terms for genes affiliated with Endemic Goiter

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Cellular components related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.2SERPINA7, TG, TPO, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00065909.5TG, TPO
2hormone biosynthetic processGO:00424469.2TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet