MCID: END028
MIFTS: 47

Endemic Goiter malady

Endocrine diseases category

Summaries for Endemic Goiter

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MalaCards: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Insulin secretion and Allograft rejection. The compounds cycloheximide and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Endemic Goiter

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

endemic goiter 8 44 60
iodine-deficiency-related goitre, unspecified 8
iodine-deficiency-related goiter, unspecified 8
iodine-deficiency-related endemic goiter 8
iodine-deficiency-related endemic goitre 8
goiter, specified as simple 8
simple goiter 8
simple goitre 8


External Ids:

Disease Ontology8 DOID:13198
ICD9CM27 240.0
NCIt39 C35023
MeSH34 D006043
ICD1025 E01.2

Related Diseases for Endemic Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.9TG, TPO, TSHR, SERPINA7, TRH
2thyroiditis31.4TRH, SERPINA7, TSHR, TPO, TG
3thyroid cancer30.6TG, TPO, TSHR, TRH
4hypothyroidism30.6IGFBP3, TRH, SERPINA7, TSHR, TPO, TG
5thyrotoxicosis30.5TRH, SERPINA7, TSHR, TPO, TG
6autoimmune thyroiditis30.4TPO, TG
7multinodular goiter30.3TSHR, TPO, TG
8nontoxic goiter30.1TG, TPO, TSHR
9follicular thyroid carcinoma30.1TSHR, TG
10nodular goiter30.1TSHR, TPO, TG
11adenoma30.0TG, TPO, TSHR, TRH, IGFBP3
12hyperthyroidism30.0TRH, SERPINA7, TSHR, TPO, TG
13pendred syndrome30.0TG, TPO
14cerebritis10.2
15hyperparathyroidism10.2
16acute thyroiditis10.1
17primary hyperparathyroidism10.1
18chagas disease10.1
19mutism10.1
20tonsillitis10.1
21thyroid medullary carcinoma10.1
22parathyroid adenoma10.1
23neurologic diseases10.1
24turner syndrome10.0IGFBP3
25diabetes mellitus10.0IGFBP3
26infertility10.0TPO
27subacute thyroiditis10.0TG
28dwarfism10.0IGFBP3
29neonatal thyrotoxicosis10.0TSHR
30breast cancer10.0IGFBP3
31anovulation10.0IGFBP3
32diabetes insipidus10.0TRH
33endogenous depression10.0TRH
34cushing's syndrome10.0TRH
35empty sella syndrome10.0TRH
36pernicious anemia10.0TPO, TG
37addison's disease10.0TG, TPO
38plummer's disease10.0TPO, TG
39thyrotropin deficiency, isolated10.0TPO, TG
40renal clear cell carcinoma10.0IGFBP3
41struma ovarii10.0TSHR, TG
42pregnancy loss10.0TPO, TG
43down syndrome10.0TPO, TSHR
44hyperprolactinemia10.0TRH
45hepatitis10.0SERPINA7
46celiac disease10.0TG, TPO
47premature ovarian failure10.0IGFBP3, TPO
48li-fraumeni syndrome10.0IGFBP3, TPO
49precocious puberty10.0TSHR, IGFBP3
50toxic diffuse goiter10.0TG, TPO, TSHR

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Clinical Features for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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32MalaCards
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MalaCards organs/tissues related to Endemic Goiter:

32
Thyroid, Testes, Cortex, Bone, Tonsil, Pituitary

Animal Models for Endemic Goiter or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endemic Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TG, TPO, TSHR, TRH, IGFBP3
2MP:00053797.6TG, TPO, TSHR, TRH, IGFBP3
3MP:00053787.4IGFBP3, TRH, TSHR, TPO, TG

Publications for Endemic Goiter

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50PubMed
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Articles related to Endemic Goiter:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Role of bamboo-shoot in the pathogenesis of endemic goiter in manipur, north East India. (23186959)
2013
2
State of the art: surgery for endemic goiter. (22083604)
2012
3
Thyroid autoimmunity role in the evolution of endemic goiter in rural area, Fars, Iran. (21529102)
2011
4
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India. (19554805)
2009
5
Clinical importance of solitary solid nodule of the thyroid in endemic goiter region. (16199924)
2005
6
Accuracy of preoperative pinhole subtraction single photon emission computed tomography for patients with primary and recurrent hyperparathyroidism in an endemic goiter area. (15170543)
2004
7
Impact of localization studies on feasibility of minimally invasive parathyroidectomy in an endemic goiter region. (12691928)
2003
8
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
9
Nodular goiter and thyroid carcinoma in children and adolescents in a moderate endemic area (lower Silesia-Sudeten endemia) in the last twelve years. (10703536)
1999
10
Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. (9398711)
1997
11
Technetium-99m-MIBI scintigraphy of thyroid nodules in an endemic goiter area. (8998152)
1997
12
Endemic goiter. (9174714)
1997
13
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
14
Amino Acid Composition of Proteins Extracted from Endemic Goiter Glands. (12114641)
1996
15
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
16
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
17
Frequency of medullary thyroid carcinoma in an endemic goiter area. (2542931)
1989
18
Circadian rhythms in urinary trace element and electrolyte excretion in children with and without endemic goiter. (2631179)
1989
19
Changes in thyroid, cerebral cortex and bones of therapeutically aborted fetuses from endemic goiter region supplied with iodized salt for 5 years. (3136979)
1988
20
Immunological features of endemic goiter. (3490338)
1986
21
The effectiveness of oral iodized oil in the treatment and prophylaxis of endemic goiter. (2997259)
1985
22
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
23
Chronic lymphocytic thyroiditis in endemic goiter. (6437762)
1984
24
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
25
Endemic goiter in Vietnam. (6863473)
1983
26
TSH secretion and regulation in endemic goiter and endemic cretinism. (6304776)
1983
27
High-iodide endemic goiter. (6817996)
1982
28
Evidence that cassava ingestion increases thiocyanate formation: a possible etiologic factor in endemic goiter. (755045)
1978
29
Iodide organification defect in iodine deficiency endemic goiter. (263314)
1978
30
The pathogenetic significance of low iodine intake in non-endemic goiter--absolute iodine uptake. (909808)
1977
31
The acute thyroidal response to iodixed oil in severe endemic goiter. (178686)
1976
32
Factors which may alter the epidemiology of endemic goiter. (4363469)
1973
33
Circulating thyroid hormones in endemic goiter. (5012499)
1972
34
Prophylaxis of endemic goiter with iodized oil in rural Peru. (4350937)
1972
35
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
36
Endemic goiter. (5680451)
1968
37
Endemic goiter in Western New Guinea. 3. Thyroid-stimulating activity of serum from severely iodine-deficient people. (5653202)
1968
38
Endemic goiter in Misiones, Argentina: pathophysiology related to immunological phenomena. (4965465)
1967
39
A study on the endemic goiter in Madjalengka district of the Republic of Indonesia. (6077200)
1967
40
Application of computer model of iodine metabolism in the study of endemic goiter. (6032616)
1967
41
PTC TASTE SENSITIVITY AND ENDEMIC GOITER IN BRAZIL. (14255559)
1965
42
PATHOLOGIC FEATURES OF HIMALAYAN ENDEMIC GOITER. (14155028)
1964
43
Thyroid cancer and thyrotoxicosis in the United States: their relation to endemic goiter. (13734092)
1961
44
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
45
Endemic goiter in Latin America. (13134444)
1954
46
Summary report of the 1952 World Health Organization conference on endemic goiter. (13096551)
1953
47
The problem of endemic goiter in Ireland. (15412096)
1950
48
Endemic Goiter and Its Relation to Iodine Content of Food. (18012855)
1929
49
ENDEMIC GOITER IN CALIFORNIA-ITS DISTRIBUTION. (18740998)
1929
50
ENDEMIC GOITER AS A PUBLIC HEALTH PROBLEM; ADDITIONAL NOTES. (18010312)
1920

Genetic Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endemic Goiter

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Pathways for genes affiliated with Endemic Goiter

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29KEGG
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Pathways related to Endemic Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TPO
2
Hide members
9.1TG, TPO, TSHR

Compounds for genes affiliated with Endemic Goiter

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44Novoseek, 24HMDB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Endemic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.3TRH
2iodotyrosine44 2411.0TG, TPO
3diiodotyrosine4410.0TPO, TG
4perchlorate4410.0TPO, TG
5chromium449.9TPO
6carbimazole44 1110.8TSHR, TPO
7gliadin449.7TPO, TG
8amino acid449.7TSHR, TPO
9Liothyronine11 2410.6SERPINA7, TPO
10sodium iodide449.5TSHR, TPO, TG
11propylthiouracil44 2 1111.5TSHR, TG, TPO
12ghrp449.4TRH, IGFBP3
13hydrocortisone44 2 59 1112.4TRH, TPO, TG
14amiodarone44 49 28 1112.4TPO, TG, SERPINA7
15isoflavone449.4TPO, IGFBP3
16pyridostigmine44 1110.4IGFBP3, TRH
17sodium dodecylsulfate449.4TG, SERPINA7, TPO
18fenfluramine28 44 1111.3TRH, IGFBP3
19asparagine449.3TPO, TSHR, SERPINA7
20sialic acid449.3TG, TSHR, SERPINA7
21maltose44 1110.2TPO, TSHR
22agarose449.2TPO, TSHR, SERPINA7
23octreotide44 59 28 1112.1TRH, TG, IGFBP3
24prednisolone44 28 1111.1TSHR, TG, IGFBP3
25carbohydrates449.0IGFBP3, TSHR, TG
26125i448.9TPO, SERPINA7, TG, TSHR
27iodide44 249.9SERPINA7, TSHR, TPO, TG
28vitamin a44 11 2410.9TG, IGFBP3, SERPINA7
29ascorbic acid44 249.8IGFBP3, TG, TPO
30polysaccharide448.7IGFBP3, TSHR, TG, TPO
31thymidine44 249.6TSHR, TG, IGFBP3, TRH
32chloramphenicol44 2 1110.6SERPINA7, IGFBP3, TSHR
33creatinine448.5IGFBP3, SERPINA7, TG, TPO
34iodine44 249.4TPO, SERPINA7, TRH, TSHR, TG
35estradiol44 11 2410.4TRH, IGFBP3, SERPINA7, TSHR
36cholesterol44 28 11 2411.3IGFBP3, SERPINA7, TSHR, TPO
37progesterone44 59 28 11 2412.3IGFBP3, TSHR, SERPINA7, TRH
38tyrosine448.2TRH, TPO, TG, TSHR, SERPINA7
39adenylate448.2TG, TPO, IGFBP3, TSHR, TRH
40glutamate448.2IGFBP3, TRH, TSHR, TPO, TG
41alanine448.1SERPINA7, IGFBP3, TSHR, TG
42ribonucleic acid448.1TPO, TG, TSHR, SERPINA7, IGFBP3
43aspartate448.1TG, TPO, TSHR, IGFBP3, SERPINA7
44testosterone44 59 11 2411.1TG, TPO, SERPINA7, TRH, IGFBP3
45estrogen448.0SERPINA7, TG, TSHR, TRH, IGFBP3
46acth448.0IGFBP3, TRH, SERPINA7, TSHR, TPO
47methimazole44 2 119.6TPO, IGFBP3, TRH, SERPINA7, TSHR, TG
48triiodothyronine447.6TSHR, IGFBP3, SERPINA7, TG, TPO, TRH
49thyroxine44 248.6TPO, IGFBP3, TRH, SERPINA7, TSHR, TG
50arginine447.6TSHR, TG, IGFBP3, SERPINA7, TPO, TRH

GO Terms for genes affiliated with Endemic Goiter

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16Gene Ontology
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Cellular components related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1TG, SERPINA7, TRH, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2response to corticosterone stimulusGO:0514129.3SERPINA7, TRH
3thyroid hormone generationGO:0065909.3TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet