MCID: END028
MIFTS: 49

Endemic Goiter malady

Endocrine diseases, Metabolic diseases categories
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Summaries for Endemic Goiter

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MalaCards based summary: Endemic Goiter, also known as iodine-deficiency-related endemic goiter, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TG (thyroglobulin), and among its related pathways are Allograft rejection and Insulin secretion. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Endemic Goiter

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Endemic Goiter, Aliases & Descriptions:

Name: Endemic Goiter 8 44 62
Iodine-Deficiency-Related Endemic Goiter 8 62
Iodine-Deficiency-Related Goitre, Unspecified 8
Iodine-Deficiency-Related Goiter, Unspecified 8
 
Iodine-Deficiency-Related Endemic Goitre 8
Goiter, Specified As Simple 8
Simple Goitre 8
Simple Goiter 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:13198
MeSH34 D006043
NCIt39 C35023
ICD9CM27 240.0
ICD1025 E01.2

Related Diseases for Endemic Goiter

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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.5TSHR, SERPINA7, TG, TPO
2thyroiditis31.0TPO, TG, SERPINA7, TSHR
3autoimmune thyroiditis30.4TG, TPO
4pendred syndrome30.4TG, TPO
5follicular thyroid carcinoma30.4TSHR, TG
6multinodular goiter30.3TSHR, TG, TPO
7nontoxic goiter30.1TPO, TG, TSHR
8hypothyroidism30.1TPO, TG, SERPINA7, TSHR
9thyrotoxicosis30.1TSHR, SERPINA7, TG, TPO
10adenoma29.7IGFBP3, TPO, TG, TSHR
11hyperthyroidism29.6TSHR, SERPINA7, TG, TPO
12thyroid cancer10.5
13turner syndrome10.3IGFBP3
14cerebritis10.3
15hyperparathyroidism10.3
16pernicious anemia10.2TPO, TG
17plummer's disease10.2TPO, TG
18thyrotropin deficiency, isolated10.2TG, TPO
19pregnancy loss10.1TG, TPO
20struma ovarii10.1TG, TSHR
21premature ovarian failure10.1TPO, IGFBP3
22acute thyroiditis10.1
23chagas disease10.1
24mutism10.1
25tonsillitis10.1
26angiosarcoma10.1
27parathyroid adenoma10.1
28neurologic diseases10.1
29mental retardation10.1
30blindness10.1
31addison's disease10.1TPO, TG
32li-fraumeni syndrome10.1TPO, IGFBP3
33celiac disease10.1TG, TPO
34precocious puberty10.1TSHR, IGFBP3
35thyroid hormone resistance syndrome10.1SERPINA7, TG
36down syndrome10.0TSHR, TPO
37subacute thyroiditis10.0TPO, TG, TSHR
38toxic diffuse goiter10.0TSHR, TG, TPO
39myxedema9.9TPO, TG, TSHR
40nodular goiter9.9TPO, TG, TSHR
41thyroid cancer, anaplastic9.9TSHR, TG, TPO
42follicular adenoma9.9TPO, TG, TSHR
43papillary carcinoma9.9TSHR, TG, TPO
44papillary thyroid carcinoma9.9TPO, TG, TSHR
45thyroid hurthle cell carcinoma9.9TSHR, TG, TPO
46hyperglycemia9.9IGFBP3, TPO
47pre-eclampsia9.9SERPINA7, IGFBP3
48hypersensitivity reaction type ii disease9.8TSHR, TG, TPO
49liver cirrhosis9.8SERPINA7, IGFBP3
50thyroid agenesis9.8TG, SERPINA7, TSHR

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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Drug clinical trials:

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Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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MalaCards organs/tissues related to Endemic Goiter:

32
Thyroid, Testes, Cortex, Bone, Tonsil, Pituitary

Animal Models for Endemic Goiter or affiliated genes

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MGI Mouse Phenotypes related to Endemic Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4TSHR, TG, TPO, IGFBP3
2MP:00053798.3TSHR, TG, TPO, IGFBP3
3MP:00053788.1IGFBP3, TPO, TG, TSHR

Publications for Endemic Goiter

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Articles related to Endemic Goiter:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
2
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
3
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
4
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
5
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
6
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
7
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
8
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
9
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
10
Elevated anti-galactosyl antibody titers in endemic goiter. (10365681)
1999
11
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
12
Is residence in areas of endemic goiter a risk factor for thyroid cancer? (7768633)
1995
13
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
14
Is endemic goiter an autoimmune disease? (7909815)
1994
15
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
16
Measurement of serum TSH level by ultrasensitive method in inhabitants of endemic goiter area supplied with iodized salt for 25 years. (1782815)
1991
17
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
18
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
19
Serum thyroglobulin and TSH in a moderate endemic goiter area. (3742838)
1986
20
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
21
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
22
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
23
Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. (6832943)
1983
24
Nutrition and iodine versus genetic factors in endemic goiter. (6619528)
1983
25
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
26
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
27
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
28
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
29
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
30
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
31
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
32
Water-borne goitrogens and their role in the etiology of endemic goiter. (4570428)
1973
33
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
34
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
35
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
36
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
37
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
38
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
SOIL FERTILIZATION WITH COASTAL IODINE SOURCES AS A PROPHYLACTIC MEASURE AGAINST ENDEMIC GOITER. (14185893)
1964
41
THE ECOLOGY OF ENDEMIC GOITER. (14106046)
1964
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
44
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Endemic goiter. (13441193)
1957
47
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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Expression patterns in normal tissues for genes affiliated with Endemic Goiter

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Pathways for genes affiliated with Endemic Goiter

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Compounds for genes affiliated with Endemic Goiter

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Compounds related to Endemic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2410.9TG, TPO
2diiodotyrosine449.9TPO, TG
3perchlorate449.9TG, TPO
4isoflavone449.7TPO, IGFBP3
5gliadin449.7TPO, TG
6carbimazole44 1110.7TSHR, TPO
7chromium449.7TG, TPO
8amino acid449.6TSHR, TPO
9maltose44 1110.5TSHR, TPO
10cardiolipin44 1110.5TG, TPO
11liothyronine50 24 1111.4SERPINA7, TPO
12sodium iodide449.3TSHR, TG, TPO
13propylthiouracil44 2 1111.3TPO, TG, TSHR
14levonorgestrel44 61 28 1112.3IGFBP3, SERPINA7
15prednisolone44 28 1111.3IGFBP3, TG, TSHR
16carbohydrates449.2IGFBP3, TG, TSHR
17ascorbic acid44 2410.2IGFBP3, TPO, TG
18amiodarone44 50 28 1112.1TPO, TG, SERPINA7
19sodium dodecylsulfate449.1SERPINA7, TG, TPO
20vitamin a44 24 1111.0SERPINA7, TG, IGFBP3
21sialic acid449.0TG, SERPINA7, TSHR
22glutamine448.9IGFBP3, TG, TSHR
23asparagine448.9TPO, SERPINA7, TSHR
24agarose448.9TPO, SERPINA7, TSHR
25sodium44 249.9TSHR, TG, TPO
26chloramphenicol44 2 50 1111.8TSHR, SERPINA7, IGFBP3
27polysaccharide448.8TSHR, TG, TPO, IGFBP3
28adenylate448.8IGFBP3, TPO, TG, TSHR
29histidine448.8TSHR, SERPINA7, TPO
30glutamate448.7IGFBP3, TPO, TG, TSHR
31retinoic acid44 249.7IGFBP3, TPO, TG, TSHR
32cysteine448.7IGFBP3, TPO, TG, TSHR
33estradiol44 24 1110.6TSHR, SERPINA7, IGFBP3
34thymidine44 249.6TSHR, TG, IGFBP3
35creatinine448.6SERPINA7, TG, TPO, IGFBP3
36testosterone44 61 24 1111.5SERPINA7, TG, TPO, IGFBP3
37iodine44 249.5TSHR, SERPINA7, TG, TPO
38125i448.5TPO, TG, SERPINA7, TSHR
39iodide44 249.5TSHR, SERPINA7, TG, TPO
40acth448.4TSHR, SERPINA7, TPO, IGFBP3
41alanine448.4IGFBP3, TG, SERPINA7, TSHR
42estrogen448.4IGFBP3, TG, SERPINA7, TSHR
43cholesterol44 28 24 1111.4TSHR, SERPINA7, TPO, IGFBP3
44methimazole44 2 1110.0TSHR, SERPINA7, TG, TPO, IGFBP3
45triiodothyronine448.0IGFBP3, TPO, TG, SERPINA7, TSHR
46thyroxine44 249.0IGFBP3, TPO, TG, SERPINA7, TSHR
47ribonucleic acid448.0IGFBP3, TPO, TG, SERPINA7, TSHR
48aspartate448.0IGFBP3, TPO, TG, SERPINA7, TSHR
49arginine448.0IGFBP3, TPO, TG, SERPINA7, TSHR
50serine448.0IGFBP3, TG, SERPINA7, TSHR

GO Terms for genes affiliated with Endemic Goiter

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Cellular components related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2SERPINA7, TG, TPO, IGFBP3

Biological processes related to Endemic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.5TG, TPO
2hormone biosynthetic processGO:0424469.2TG, TPO

Products for genes affiliated with Endemic Goiter

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Sources for Endemic Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet