MCID: END028
MIFTS: 41

Endemic Goiter malady

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

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Aliases & Descriptions for Endemic Goiter:

Name: Endemic Goiter 10 47 12 65
Iodine-Deficiency-Related Goitre, Unspecified 10
Iodine-Deficiency-Related Goiter, Unspecified 10
Iodine-Deficiency-Related Endemic Goiter 10
Iodine-Deficiency-Related Endemic Goitre 10
 
Goiter, Specified As Simple 10
Euthyroid Goiter 65
Goiter, Endemic 36
Simple Goitre 10
Simple Goiter 10

Classifications:



External Ids:

Disease Ontology10 DOID:13198
ICD1027 E01.0, E01.2
ICD9CM29 240.0
MeSH36 D006043
NCIt42 C35023
UMLS65 C0018022, C0302859

Summaries for Endemic Goiter

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MalaCards based summary: Endemic Goiter, also known as iodine-deficiency-related goitre, unspecified, is related to goiter and thyroiditis. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways are Amine-derived hormones and Hormone ligand-binding receptors. Affiliated tissues include thyroid, breast and prostate.

Related Diseases for Endemic Goiter

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Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.5FOXI1, SERPINA7, TG
2thyroiditis31.2TG, TPO, TSHR
3nontoxic goiter11.2
4goiter, multinodular 1, with or without sertoli-leydig cell tumors11.1
5autoimmune thyroiditis10.5TG, TPO
6thyroid ectopia10.4TG, TPO
7neonatal meningitis10.4TG, TPO
8solar retinopathy10.4TG, TPO
9euthyroid sick syndrome10.4SERPINA7, TPO
10setariasis10.4TG, TPO
11chronic inflammatory demyelinating polyradiculoneuropathy10.3TG, TSHR
12iatrogenic or traumatic pituitary deficiency10.3TG, TSHR
13megaloblastic anemia10.3TG, TPO
14laryngeal mucoepidermoid carcinoma10.3CALCA, TG
15perivascular epithelioid cell tumor10.3TG, TSHR
16skin angiosarcoma10.3CALCA, TG
17scabies10.2CALCA, TG
18corneal ectasia10.2CALCA, TG
19glaucoma, primary open angle, juvenile-onset, 210.2TG, TPO
20chest wall lymphoma10.2CALCA, TG
21thyroid cancer10.2
22hypoaldosteronism10.2CALCA, TG
23fuchs' heterochromic uveitis10.1TG, TSHR
24hypothyroidism10.1
25ovarian cyst10.1CALCA, TG
26ulcerative blepharitis10.1CALCA, TPO
27hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0SERPINA7, TG, TSHR
28familial abdominal aortic aneurysm10.0TG, TPO, TSHR
29serous cystadenocarcinoma10.0TG, TPO
30rh isoimmunization10.0TG, TPO, TSHR
31bone cancer10.0CALCA, TG, TPO
32deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.0FOXI1, TG, TPO
33ovarian endometrioid cystadenoma10.0CALCA, TG, TPO
34medullary thyroid carcinoma, familial9.9CALCA, TG
35multinodular goiter9.9
36hyperparathyroidism9.9
37cerebritis9.9
38clivus chordoma9.9CALCA, TSHR
39hypothryoidism, congenital, nongoitrous 49.9TG, TPO, TSHB
40insulin-like growth factor i9.8
41angiosarcoma9.8
42tracheomalacia9.8
43tonsillitis9.8
44chagas disease9.8
45acute thyroiditis9.8
46mutism9.8
47adenoma9.8
48parathyroid adenoma9.8
49hyperthyroidism9.8
50neurologic diseases9.8

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to endemic goiter

Symptoms for Endemic Goiter

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Drugs & Therapeutics for Endemic Goiter

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Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Micronutrients3901
2Trace Elements3900
3
Iodine4947553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
4cadexomer iodine456
5Anti-Infective Agents, Local984
6Anti-Infective Agents17220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Maternal Iodine Supplementation and Effects on Thyroid Function and Child DevelopmentActive, not recruitingNCT00791466

Search NIH Clinical Center for Endemic Goiter


Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

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Anatomical Context for Endemic Goiter

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MalaCards organs/tissues related to Endemic Goiter:

33
Thyroid, Breast, Prostate, Lung, Bone, Brain, Endothelial

Animal Models for Endemic Goiter or affiliated genes

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Publications for Endemic Goiter

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Articles related to Endemic Goiter:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. (26949559)
2016
2
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
3
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
4
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
5
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. (16117293)
2005
6
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
7
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. (11936460)
2002
8
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. (12199330)
2002
9
Thyroid hormone profile in children with goiter in an endemic goiter area. (11305795)
2001
10
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
11
Elevated anti-galactosyl antibody titers in endemic goiter. (10365681)
1999
12
Complications of 867 thyroidectomies performed in a region of endemic goiter in Turkey. (9028995)
1996
13
Is residence in areas of endemic goiter a risk factor for thyroid cancer? (7768633)
1995
14
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
15
Is endemic goiter an autoimmune disease? (7909815)
1994
16
Endemic goiter in Calabria: etiopathogenesis and thyroid function. (8077616)
1994
17
Measurement of serum TSH level by ultrasensitive method in inhabitants of endemic goiter area supplied with iodized salt for 25 years. (1782815)
1991
18
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
19
Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. (2745935)
1989
20
Serum thyroglobulin and TSH in a moderate endemic goiter area. (3742838)
1986
21
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
22
Morphologic study on cerebral cortex development in therapeutically aborted fetuses in an endemic goiter region in Guizhou. (6428836)
1984
23
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
24
Epidemiology and genetics of endemic goiter. I. Epidemiological aspects. (6832943)
1983
25
Nutrition and iodine versus genetic factors in endemic goiter. (6619528)
1983
26
3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. (263309)
1978
27
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
28
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
29
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
30
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
31
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
32
Water-borne goitrogens and their role in the etiology of endemic goiter. (4570428)
1973
33
Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. (4749452)
1973
34
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
35
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
36
Plasma TSH levels in endemic goiter subjects. (4193197)
1970
37
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
38
Endemic goiter in Greece: epidemiologic and genetic studies. (5917032)
1966
39
THE PROBLEM OF ENDEMIC GOITER IN WADI ARA AND THE JORDAN VALLEY--NORTHERN ISRAEL. (14252800)
1965
40
SOIL FERTILIZATION WITH COASTAL IODINE SOURCES AS A PROPHYLACTIC MEASURE AGAINST ENDEMIC GOITER. (14185893)
1964
41
THE ECOLOGY OF ENDEMIC GOITER. (14106046)
1964
42
Endemic goiter. I. Introduction and etiology. (14471215)
1962
43
Endemic goiter. III. Iodine deficiency as a public health problem. (14471217)
1962
44
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Endemic goiter. (13441193)
1957
47
Carcinoma and thyroid nodules; the problem in an endemic goiter area. (13236008)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Endemic Goiter

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Expression for genes affiliated with Endemic Goiter

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Search GEO for disease gene expression data for Endemic Goiter.

Pathways for genes affiliated with Endemic Goiter

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GO Terms for genes affiliated with Endemic Goiter

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Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.8TG, TPO
2activation of adenylate cyclase activityGO:00071909.5CALCA, TSHR
3thyroid hormone generationGO:00065909.5TG, TPO
4cell-cell signalingGO:00072678.8CALCA, TSHB, TSHR

Sources for Endemic Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet