MCID: END028
MIFTS: 35

Endemic Goiter malady

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

Aliases & Descriptions for Endemic Goiter:

Name: Endemic Goiter 12 52 14 69
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 69
Goiter, Endemic 42
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD10 33 E01.0 E01.2
ICD9CM 35 240.0
MeSH 42 D006043
NCIt 47 C35023
UMLS 69 C0018022

Summaries for Endemic Goiter

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to nontoxic goiter and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Insulin secretion. The drugs Anti-Infective Agents and Anti-Infective Agents, Local have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 nontoxic goiter 11.0
2 goiter, multinodular 1, with or without sertoli-leydig cell tumors 11.0
3 goiter 10.9
4 thyroiditis 10.6
5 fibrous meningioma 10.2 TG TPO
6 premature closure of the arterial duct 10.1 TG TPO
7 congenital nonspherocytic hemolytic anemia 10.1 SERPINA7 TPO
8 echinostomiasis 10.1 SERPINA7 TG
9 tick paralysis 10.1 TG TPO
10 frontal sinusitis 10.1 TG TPO
11 acute hemorrhagic encephalitis 10.1 TG TSHR
12 gastrinoma 10.1 TG TSHR
13 mesocardia 10.1 TG TSHR
14 parachordoma 10.1 TG TSHR
15 color blindness 10.1 TG TPO
16 thyroid cancer 10.0
17 dysautonomia, familial 10.0 TG TPO
18 extrahepatic bile duct adenocarcinoma 10.0 SERPINA7 TG TPO
19 hypothyroidism 10.0
20 neuhauser daly magnelli syndrome 10.0 TG TPO TSHR
21 conjunctival deposit 10.0 TG TPO TSHR
22 nodular prostate 10.0 TG TPO TSHR
23 denys-drash syndrome 10.0 TG TPO TSHR
24 peritoneal serous papillary adenocarcinoma 10.0 TG TPO TSHR
25 neuronopathy, distal hereditary motor, type viia 10.0 SERPINA7 TG TSHR
26 choreoathetosis, hypothyroidism, and neonatal respiratory distress 10.0 TG TPO TSHR
27 tenosynovitis of foot and ankle 10.0 TG TPO TSHR
28 muscular dystrophy-dystroglycanopathy , type a, 10 10.0 TG TPO TSHR
29 articulation disorder 10.0 TG TPO TSHR
30 acute laryngitis 9.9 TG TSHR
31 dihydrolipoamide dehydrogenase deficiency 9.9 TG TPO
32 peritoneal mesothelioma 9.9 TG TPO TSHR
33 caudal regression syndrome 9.9 TG TPO TSHB
34 mixed eosinophil-basophil adenoma 9.8 SERPINA7 TG TPO TSHR
35 hypothyroidism, congenital, nongoitrous, 1 9.8 SERPINA7 TG TPO TSHR
36 broad ligament malignant neoplasm 9.8 SERPINA7 TG TPO TSHR
37 janus kinase-3 deficiency 9.8 SERPINA7 TG TPO TSHR
38 glomangiomyoma 9.8 SERPINA7 TG TPO TSHR
39 pulsating exophthalmos 9.8 SERPINA7 TG TPO TSHR
40 multinodular goiter 9.8
41 hyperparathyroidism 9.8
42 cerebritis 9.8
43 exanthema subitum 9.8 DICER1 TG TPO TSHR
44 non-distal monosomy 10q 9.8 DICER1 TG TPO TSHR
45 commensal bacterial infectious disease 9.7 TG TPO TSHB TSHR
46 diabetes mellitus, insulin-dependent, 12 9.7 TG TPO TSHB TSHR
47 angiosarcoma 9.7
48 hyperthyroidism 9.7
49 differentiated thyroid carcinoma 9.7
50 tracheomalacia 9.7

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Anti-Infective Agents, Local
3 cadexomer iodine
4
Iodine 7553-56-2 807
5 Micronutrients
6 Trace Elements

Interventional clinical trials:


id Name Status NCT ID Phase
1 Maternal Iodine Supplementation and Effects on Thyroid Function and Child Development Completed NCT00791466
2 Exploration of Effects of Excessive Iodine on Children and Tolerable Upper Intake Level of Iodine for Children Completed NCT02915536

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

39
Thyroid, Testes, Cortex, Bone, Pituitary, Tonsil

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 325)
id Title Authors Year
1
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. ( 26949559 )
2016
2
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. ( 25289092 )
2014
3
Surgical treatment of endemic goiter in a nonhospital setting without general anesthesia in Africa. ( 24728536 )
2014
4
The Association between Cobalt Deficiency and Endemic Goiter in School-Aged Children. ( 25309789 )
2014
5
Role of bamboo-shoot in the pathogenesis of endemic goiter in manipur, north East India. ( 23186959 )
2013
6
State of the art: surgery for endemic goiter. ( 22083604 )
2012
7
Single lobe disease in cases of advanced endemic goiter: a new phenotype. ( 24783020 )
2012
8
Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region. ( 22302284 )
2012
9
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. ( 21523503 )
2011
10
Endemic goiter--individual risk factors necessitate individual treatment. ( 22006052 )
2011
11
State of the art: surgery for endemic goiter--a plea for individualizing the extent of resection instead of heading for routine total thyroidectomy. ( 21630080 )
2011
12
Thyroid autoimmunity role in the evolution of endemic goiter in rural area, Fars, Iran. ( 21529102 )
2011
13
INCAP studies of endemic goiter and its prevention. ( 20461908 )
2010
14
Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. ( 19474675 )
2009
15
Evidence of endemic goiter and iodine deficiency in a mountainous area of Haiti. ( 19454392 )
2009
16
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. ( 19494708 )
2009
17
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India. ( 19554805 )
2009
18
Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter. ( 20302029 )
2009
19
Iodine deficiency and endemic goiter: a national tragedy. ( 18599928 )
2008
20
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? ( 18202924 )
2008
21
Endemic goiter in Semirom; there is no difference in vitamin A status between goitrous and nongoitrous children. ( 19155579 )
2008
22
The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity. ( 17324915 )
2007
23
Endemic goiter due to thyroglobulin gene abnormality and social ostracism. ( 17446654 )
2007
24
Evaluation of endemic goiter prevalence in Bulgarian schoolchildren: results from national strategies for prevention and control of iodine-deficiency disorders. ( 17709907 )
2007
25
High incidence of tracheomalacia in longstanding goiters: experience from an endemic goiter region. ( 17354028 )
2007
26
Clinical importance of solitary thyroid nodule of the thyroid in endemic goiter region. ( 16790952 )
2006
27
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. ( 16117293 )
2005
28
Clinical importance of solitary solid nodule of the thyroid in endemic goiter region. ( 16199924 )
2005
29
Accuracy of preoperative pinhole subtraction single photon emission computed tomography for patients with primary and recurrent hyperparathyroidism in an endemic goiter area. ( 15170543 )
2004
30
Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region. ( 15027890 )
2004
31
Application of staging systems for differentiated thyroid carcinoma in an endemic goiter region with iodine substitution. ( 12560781 )
2003
32
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. ( 12660642 )
2003
33
Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter area. ( 12762644 )
2003
34
Impact of localization studies on feasibility of minimally invasive parathyroidectomy in an endemic goiter region. ( 12691928 )
2003
35
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. ( 12666822 )
2002
36
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. ( 12504972 )
2002
37
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. ( 12199330 )
2002
38
Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. ( 12207166 )
2002
39
Endemic goiter--an update. ( 17018443 )
2002
40
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. ( 11936460 )
2002
41
Limited sensitivity of parathyroid imaging with (99m)Tc-sestamibi/(123)I subtraction in an endemic goiter area. ( 12215555 )
2002
42
Dietary supplies of iodine and thiocyanate in the etiology of endemic goiter in Tripura. ( 11407152 )
2001
43
Changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter. ( 11258455 )
2001
44
Thyroid hormone profile in children with goiter in an endemic goiter area. ( 11305795 )
2001
45
Endemic goiter and cretinism: an update on iodine status. ( 11837501 )
2001
46
Endemic goiter, thiocyanate overload, and selenium status in school-age children. ( 11330518 )
2001
47
Minimally invasive open parathyroidectomy in an endemic goiter area: a prospective study. ( 11448396 )
2001
48
Endemic goiter with iodine sufficiency: a possible role for the consumption of pearl millet in the etiology of endemic goiter. ( 10617947 )
2000
49
Endemic goiter associated with high iodine intake. ( 11030003 )
2000
50
Short-term effectiveness of mandatory iodization of table salt, at an elevated iodine concentration, on the iodine and goiter status of schoolchildren with endemic goiter. ( 10617949 )
2000

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 8.96 TSHB TSHR
2 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TG TSHB

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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