MCID: END033
MIFTS: 48

Endocarditis malady

Summaries for Endocarditis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards: Endocarditis is related to infective endocarditis and subacute bacterial endocarditis. An important gene associated with Endocarditis is CFP (complement factor properdin). The drug gentamicin sulfate pwdr and the compounds superoxide and serine have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotype immune system.

Disease Ontology:8 A heart disease involving non-infectious inflammation of the endocardium (inner layer of the heart).

Wikipedia:63 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Aliases & Classifications for Endocarditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

endocarditis 8 10 44 33 60


External Ids:

Disease Ontology8 DOID:10314
MeSH34 D004696
NCIt39 C34582

Related Diseases for Endocarditis

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17GeneCards, 18GeneDecks
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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1infective endocarditis31.7LECT1, AMDHD2
2subacute bacterial endocarditis31.6PRTN3
3meningitis30.6FCGR2A, LACTB, CFP, PRF1, LBP
4bacterial meningitis30.3LBP, CFP, LACTB
5pneumonia30.2LBP, PRF1, EPX, LACTB
6arthritis30.2LBP, PRTN3, FCGR2A, LACTB
7leukemia30.2EPX, LACTB, DLL1, PRTN3
8endophthalmitis30.0LACTB, PRF1
9rheumatoid arthritis29.8FCGR2A, LBP, PRTN3
10tuberculosis29.8PRF1, LACTB, EPX
11congenital heart defect29.8CS, TNNI3, EPX
12myeloid leukemia29.6PRTN3
13q fever10.6
14marantic endocarditis10.6
15glomerulonephritis10.5
16cerebritis10.5
17rheumatic fever10.4
18loeffler endocarditis10.4
19ventricular septal defect10.4
20mitral valve prolapse10.4
21splenic abscess10.4
22aortitis10.3
23aortic aneurysm10.3
24crescentic glomerulonephritis10.3
25myocardial infarction10.3
26kawasaki disease10.3
27pericarditis10.3
28discitis10.3
29antiphospholipid syndrome10.3
30tetralogy of fallot10.2
31patent ductus arteriosus10.2
32congestive heart failure10.2
33pulmonary embolism10.2
34epidural abscess10.1
35systemic lupus erythematosus10.1
36subacute glomerulonephritis10.1
37tricuspid valve stenosis10.1
38hypertrophic cardiomyopathy10.1
39disseminated intravascular coagulation10.1
40lupus erythematosus10.1
41purpura10.1
42stroke, ischemic10.1
43diphtheria10.1
44rapidly progressive glomerulonephritis10.1
45splenic infarction10.1
46endomyocardial fibrosis10.1
47splenic artery aneurysm10.1
48acute leukemia10.1
49brucellosis10.1
50diffuse glomerulonephritis10.1

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to endocarditis

Clinical Features for Endocarditis

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Drugs & Therapeutics for Endocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endocarditis

Drug clinical trials:

Search ClinicalTrials for Endocarditis

Search NIH Clinical Center for Endocarditis

Search CenterWatch for Endocarditis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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32MalaCards
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MalaCards organs/tissues related to Endocarditis:

32
Heart, Skin, Lung, Testes, Colon, Kidney, Brain, Liver, Spleen, T cells, Endothelial, Thyroid, Prostate, Breast, Myeloid, Monocytes, Bone

Animal Models for Endocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9AQP9, PRTN3, PRF1, EPX, CYTIP, DLL1

Publications for Endocarditis

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50PubMed
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Articles related to Endocarditis:

(show top 50)    (show all 1758)
idTitleAuthorsYear
1
The bacteremia of dental origin and its implications in the appearance of bacterial endocarditis. (24121925)
2014
2
Transthoracic Echocardiographic Detection of Pulmonary Valve Involvement in LAPeffler's Endocarditis. (24102642)
2014
3
CT angiography and A^a8,F-FDG-PET fusion imaging for prosthetic heart valve endocarditis. (24029372)
2013
4
OPAT outcomes in endocarditis. (23615590)
2013
5
Infective endocarditis in previously healthy children with structurally normal hearts. (23483241)
2013
6
Inflammatory parameters and prediction of prognosis in infective endocarditis. (23767848)
2013
7
Management strategies and outcome for prosthetic valve endocarditis. (23831161)
2013
8
Neurological complications in infective endocarditis. (24292228)
2013
9
Role of radiolabelled leucocyte scintigraphy in patients with a suspicion of prosthetic valve endocarditis and inconclusive echocardiography. (23456094)
2013
10
Infective endocarditis leading to acute aortic insufficiency, ventricular septal defect, and colonic ischemia. (23896231)
2013
11
Isolated pulmonary infective endocarditis with septic pulmonary embolism complicating a right ventricular outflow tract obstruction: scarce and devious presentation. (24106634)
2013
12
Mycotic Inferior Mesenteric Artery Aneurysm secondary to Native Valve Endocarditis caused by Coagulase Negative Staphylococcus. (24333529)
2013
13
Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora. (23044056)
2013
14
Reply: positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis. (23747782)
2013
15
Native valve right sided infective endocarditis. (23369408)
2013
16
Acute myocardial infarction in a patient with chronic renal failure and endocarditis. (23797446)
2013
17
A case of prosthetic valve endocarditis caused by Streptococcus constellatus as a rare agent of endocarditis. (23831301)
2013
18
Bioprosthetic mitral valve endocarditis after percutaneous device closure of severe paravalvular leak. (23608262)
2013
19
Percutaneous closure of an aorto-atrial fistula after surgery for infective endocarditis. (22721671)
2012
20
eComment. Left ventricle pseudoaneurysm secondary to infective endocarditis. (22354910)
2012
21
Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia. (22505676)
2012
22
Rapidly progrediating aortic valve infective endocarditis in an intravenous drug user treated by antibiotics and surgery. (23101277)
2012
23
Cystatin C in a composite risk score for mortality in patients with infective endocarditis: a cohort study. (22798251)
2012
24
The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis. (22319637)
2012
25
Aortic valve repair for active infective endocarditis. (22345288)
2012
26
Infective endocarditis in infancy after complete atrioventricular septal defect repair. (23804699)
2012
27
Predictors of embolic events in pediatric infective endocarditis. (22734342)
2011
28
Gerbode defect following endocarditis and misinterpreted as severe pulmonary arterial hypertension. (20920293)
2010
29
Lipopolysaccharide-binding protein (LBP) gene polymorphisms: rapid genotyping by real-time PCR and association with infective endocarditis. (19560454)
2009
30
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
31
Streptococcus bovis discitis and possible endocarditis. (10939547)
2000
32
Candida endocarditis in association with myelodysplastic syndromes: review of the literature and report of a case. (17312671)
1999
33
Kingella kingae endocarditis following chickenpox in infancy. (9495681)
1997
34
Endocarditis associated with infectious discitis. (8938877)
1996
35
Rheumatoid factors in subacute bacterial endocarditis and other infectious diseases. (3070727)
1988
36
Inflammation of the temporal artery associated with subacute bacterial endocarditis and hepatitis B antigen. (7387456)
1980
37
Staphylococcal septicemia and disseminated intravascular coagulation. Staphylococcus aureus endocarditis mimicking meningococcemia. (879923)
1977
38
Osler's node of subacute bacterial endocarditis. Focal necrotizing vaculitis of the glomus body. (6016316)
1967
39
Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)
1967
40
NEW CUTANEOUS SYNDROME IN SUBACUTE BACTERIAL ENDOCARDITIS. (14090398)
1964
41
Subacute bacterial endocarditis presenting as acquired vascular purpura with abnormal bleeding from ovarian follicles. (13706617)
1961
42
Subacute bacterial endocarditis due to coagulase-negative Staphylococcus albus. (13803905)
1960
43
Deaf or dead? A case of subacute bacterial endocarditis treated with penicillin and neomycin. (13629091)
1959
44
Prognosis in subacute bacterial endocarditis. (13482247)
1957
45
The action of six antibiotics singly and in combination on enterococci isolated from cases of subacute bacterial endocarditis. (13307091)
1956
46
Streptococci of the mouth and their relationship to subacute bacterial endocarditis. (13047292)
1953
47
Right-sided endocarditis on a patent foramen ovale associated with periarteritis nodosa. (12976960)
1952
48
Subacute bacterial endocarditis. (15437175)
1950
49
Subacute bacterial endocarditis. (15396939)
1949
50
Caronamide as an adjuvant to penicillin in the treatment of subacute bacterial endocarditis. (18107738)
1949

Genetic Variations for Endocarditis

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Expression for genes affiliated with Endocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endocarditis

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Pathways for genes affiliated with Endocarditis

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Compounds for genes affiliated with Endocarditis

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44Novoseek, 24HMDB
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Compounds related to Endocarditis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1superoxide44 2411.9CFP, EPX, PRF1, PRTN3, LBP, CS
2serine4410.8CS, LBP, PRTN3, EPX, FCGR2A, LACTB
3lipid4410.7FCGR2A, LECT1, EPX, PRTN3, LBP, CS
4fmlp4410.7PRTN3, EPX, FCGR2A, CEACAM8
5histidine4410.5GTF3A, FCGR2A, PRF1, CS
6p0024410.3CS, PRTN3, EPX

GO Terms for genes affiliated with Endocarditis

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Products for genes affiliated with Endocarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet