MCID: END033
MIFTS: 42

Endocarditis malady

Summaries for Endocarditis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards: Endocarditis is related to subacute bacterial endocarditis and bacteremia. An important gene associated with Endocarditis is CFP (complement factor properdin). The drug gentamicin sulfate pwdr and the compounds superoxide and serine have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Disease Ontology:8 A heart disease involving non-infectious inflammation of the endocardium (inner layer of the heart).

Wikipedia:64 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Aliases & Classifications for Endocarditis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

endocarditis 8 10 45 34 61


External Ids:

Disease Ontology8 DOID:10314
MeSH35 D004696
NCIt40 C34582

Related Diseases for Endocarditis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Endocarditis family:

subacute bacterial endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1subacute bacterial endocarditis31.7PRTN3
2bacteremia30.6LBP, LACTB
3arthritis30.3LBP, PRTN3, FCGR2A, LACTB
4bacterial meningitis30.2LACTB, CFP, LBP
5tuberculosis29.9LACTB, EPX, PRF1
6septic shock29.9LBP, CFP, LACTB
7sepsis29.9LACTB, CFP
8marantic endocarditis10.6
9loeffler endocarditis10.5
10rheumatic fever10.4
11ventricular septal defect10.4
12rheumatic disease10.4
13mitral valve prolapse10.4
14splenic abscess10.4
15aortitis10.3
16n syndrome10.3
17aortic aneurysm10.3
18hypereosinophilic syndrome10.3
19mycobacterium fortuitum10.3
20crescentic glomerulonephritis10.3
21loeffler syndrome10.3
22kawasaki disease10.3
23stenotrophomonas maltophilia10.3
24discitis10.3
25antiphospholipid syndrome10.3
26gerbode defect10.3
27q fever10.2
28patent ductus arteriosus10.2
29epidural abscess10.2
30systemic lupus erythematosus10.2
31subacute glomerulonephritis10.2
32tricuspid valve stenosis10.2
33hypertrophic cardiomyopathy10.2
34stroke, ischemic10.1
35marfan syndrome10.1
36diphtheria10.1
37rapidly progressive glomerulonephritis10.1
38endomyocardial fibrosis10.1
39splenic artery aneurysm10.1
40acute leukemia10.1
41aortic coarctation10.1
42blindness10.1
43acalculous cholecystitis10.1
44patent foramen ovale10.1
45coronary aneurysm10.1
46discrete subaortic stenosis10.1
47pancytopenia10.1
48splenic infarction10.1
49cortical blindness10.1
50septic arthritis10.1

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to endocarditis

Clinical Features for Endocarditis

Drugs & Therapeutics for Endocarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Endocarditis

Drug clinical trials:

Search ClinicalTrials for Endocarditis

Search NIH Clinical Center for Endocarditis

Search CenterWatch for Endocarditis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

Animal Models for Endocarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Endocarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9AQP9, PRTN3, PRF1, EPX, CYTIP, DLL1

Publications for Endocarditis

Sources:
51PubMed
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Articles related to Endocarditis:

(show top 50)    (show all 1758)
idTitleAuthorsYear
1
Echocardiographic measurement of cardiac valvular thickness in healthy cows, cows with bacterial endocarditis, and cows with cardiorespiratory diseases. (24252809)
2013
2
Triple cusps replacement for active aortic endocarditis. (23557585)
2013
3
A case of endocarditis caused by Lactococcus garvieae and suggested methods for identification. (23554190)
2013
4
Treatment of Gram-positive left-sided infective endocarditis with daptomycin. (23299359)
2013
5
Enterococcus faecalis infective endocarditis: focus on clinical aspects. (24073680)
2013
6
Mitral regurgitation jet around neoannulus: mitral valve replacement in erysipelothrix rhusiopathiae endocarditis. (23545868)
2013
7
Surgical repair of complex endocarditis. (24135325)
2013
8
Age adjusted Charlson Co-morbidity Index is an independent predictor of mortality over long-term follow-up in infective endocarditis. (23978361)
2013
9
Comment on diffuse alveolar hemorrhage and Libman-Sacks endocarditis as a manifestation of possible primary antiphospholipid syndrome. (23884191)
2013
10
Suspected endocarditis after CoreValve implantation: a word of caution. (23618976)
2013
11
Radial mycotic aneurysm complicated with infective endocarditis caused by Streptococcus sanguinis. (24126401)
2013
12
Delayed diagnosis of infective endocarditis in a child with a normal heart. (22700385)
2013
13
Effectiveness of mechanical embolectomy for septic embolus in the cerebral artery complicated with infective endocarditis. (23960455)
2013
14
Multimodality imaging reveals regurgitant jet lesion in aneurysmal anterior mitral leaflet: a severe complication of endocarditis. (24334713)
2013
15
Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis. (23747770)
2013
16
Nonbacterial endocarditis presenting as a right ventricular tumor in assumed BehAset's disease. (24297403)
2013
17
Prognostic role of persistent positive blood cultures after initiation of antibiotic therapy in left-sided infective endocarditis. (23144047)
2013
18
Technique to treat extensive abscesses in double valve replacement for prosthetic valve endocarditis. (24224423)
2013
19
Complete atrioventricular block and infective endocarditis in a patient with hypertrophic obstructive cardiomyopathy. (22466832)
2012
20
Cardiac calciphylaxis presenting as endocarditis. (21900291)
2012
21
Atypical malignant late infective endocarditis of Melody valve. (22284627)
2012
22
Infective endocarditis caused by community-associated methicillin-resistant Staphylococcus aureus in a previously healthy preschool child. (22575428)
2012
23
Pseudoaneurysm of mitro-aortic intervalvular fibrosa during the course of mitral valve endocarditis with aorto-left ventricle outflow tract fistula. (23960696)
2012
24
Q fever endocarditis in Spain. Clinical characteristics and outcome. (21333397)
2011
25
Successful treatment of pediatric endocarditis and pericarditis due to MRSA with linezolid. (21717862)
2011
26
Real-time polymerase chain reaction seems not to be superior to blood cultures in anticipating valve sterilization in infective endocarditis. (22143022)
2011
27
Non-bacterial thrombotic endocarditis with systemic embolic events caused by adenomyosis. (21827568)
2011
28
Protein-losing enteropathy post-valvular surgery with severe tricuspid regurgitation in Subutex-related endocarditis. (19421664)
2009
29
Bacterial endocarditis and septic arthritis in a patient with severe hemophilia A: a case report. (19415014)
2009
30
Hypereosinophilic syndrome with isolated Loeffler's endocarditis: complete resolution with corticosteroids. (18480530)
2008
31
Q fever endocarditis: the Mayo Clinic experience. (18626237)
2008
32
Left atrial appendage thrombus in a patient in sinus rhythm with endocarditis and a severe aortic valve insufficiency. (18841267)
2008
33
Q Fever Presenting As Recurrent, Culture-negative Endocarditis with Aortic Prosthetic Valve Failure: A Case Report and Review of the Literature. (18382649)
2006
34
Does steroid exposure adversely affect the outcome of subacute bacterial endocarditis? Report of two cases. (16449009)
2006
35
Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. (16188499)
2005
36
Splenic abscess associated with endocarditis in a patient on hemodialysis: a case report. (15832007)
2005
37
Virulence factors of Staphylococcus aureus strains causing infective endocarditis--a comparison with strains from skin infections. (9808417)
1998
38
Atypical presentation of papillary fibroelastoma mimicking multiple vegetations in suspected subacute bacterial endocarditis. (8480605)
1993
39
Right-sided infective endocarditis with acquired tricuspid valve stenosis associated with transvenous pacemaker: a case report. (1715545)
1991
40
QT sensing rate responsive pacing during subacute bacterial endocarditis: a case report. (1700380)
1990
41
Immunosuppressive therapy and plasmapheresis in rapidly progressive glomerulonephritis associated with bacterial endocarditis. (3706297)
1986
42
Neuraminidase production by a Streptococcus sanguis strain associated with subacute bacterial endocarditis. (6874067)
1983
43
Induction of dental caries in gnotobiotic rats with a levan-forming streptococcus and a streptococcus isolated from subacute bacterial endocarditis. (5239006)
1968
44
Subacute bacterial endocarditis in old persons. (13828408)
1960
45
Meningeal manifestations of subacute bacterial endocarditis. (13483917)
1957
46
Antibiotic therapy of bacterial endocarditis. II. Current trends in the treatment of subacute bacterial endocarditis. (13002201)
1952
47
Subacute Bacterial Endocarditis. (14937472)
1952
48
Subacute bacterial endocarditis; laboratory aspects. (18123666)
1949
49
On congestive heart failure after clinically healed subacute bacterial endocarditis. (18864134)
1948
50
Sulfonamide therapy of subacute bacterial endocarditis. (18920944)
1948

Genetic Variations for Endocarditis

Expression for genes affiliated with Endocarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for genes affiliated with Endocarditis

Compounds for genes affiliated with Endocarditis

Sources:
45Novoseek, 24HMDB
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Compounds related to Endocarditis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1superoxide45 2411.9CFP, EPX, PRF1, PRTN3, LBP, CS
2serine4510.8CS, LBP, PRTN3, EPX, FCGR2A, LACTB
3lipid4510.7FCGR2A, LECT1, EPX, PRTN3, LBP, CS
4fmlp4510.7PRTN3, EPX, FCGR2A, CEACAM8
5histidine4510.5GTF3A, FCGR2A, PRF1, CS
6p0024510.3CS, PRTN3, EPX

GO Terms for genes affiliated with Endocarditis

Products for genes affiliated with Endocarditis

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Sources for Endocarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet