MCID: END033
MIFTS: 48

Endocarditis malady

Summaries for Endocarditis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards: Endocarditis is related to infective endocarditis and subacute bacterial endocarditis. An important gene associated with Endocarditis is CFP (complement factor properdin). The drug gentamicin sulfate pwdr and the compounds superoxide and serine have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotype immune system.

Disease Ontology:8 A heart disease involving non-infectious inflammation of the endocardium (inner layer of the heart).

Wikipedia:63 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Aliases & Classifications for Endocarditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

endocarditis 8 10 44 33 60


External Ids:

Disease Ontology8 DOID:10314
MeSH34 D004696
NCIt39 C34582

Related Diseases for Endocarditis

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17GeneCards, 18GeneDecks
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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1infective endocarditis31.7LECT1, AMDHD2
2subacute bacterial endocarditis31.6PRTN3
3meningitis30.6FCGR2A, LACTB, CFP, PRF1, LBP
4bacterial meningitis30.3LBP, CFP, LACTB
5pneumonia30.2LBP, PRF1, EPX, LACTB
6arthritis30.2LBP, PRTN3, FCGR2A, LACTB
7leukemia30.2EPX, LACTB, DLL1, PRTN3
8endophthalmitis30.0LACTB, PRF1
9rheumatoid arthritis29.8FCGR2A, LBP, PRTN3
10tuberculosis29.8PRF1, LACTB, EPX
11congenital heart defect29.8CS, TNNI3, EPX
12myeloid leukemia29.6PRTN3
13q fever10.6
14marantic endocarditis10.6
15glomerulonephritis10.5
16cerebritis10.5
17rheumatic fever10.4
18loeffler endocarditis10.4
19ventricular septal defect10.4
20mitral valve prolapse10.4
21splenic abscess10.4
22aortitis10.3
23aortic aneurysm10.3
24crescentic glomerulonephritis10.3
25myocardial infarction10.3
26kawasaki disease10.3
27pericarditis10.3
28discitis10.3
29antiphospholipid syndrome10.3
30tetralogy of fallot10.2
31patent ductus arteriosus10.2
32congestive heart failure10.2
33pulmonary embolism10.2
34epidural abscess10.1
35systemic lupus erythematosus10.1
36subacute glomerulonephritis10.1
37tricuspid valve stenosis10.1
38hypertrophic cardiomyopathy10.1
39disseminated intravascular coagulation10.1
40lupus erythematosus10.1
41purpura10.1
42stroke, ischemic10.1
43diphtheria10.1
44rapidly progressive glomerulonephritis10.1
45splenic infarction10.1
46endomyocardial fibrosis10.1
47splenic artery aneurysm10.1
48acute leukemia10.1
49brucellosis10.1
50diffuse glomerulonephritis10.1

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to endocarditis

Clinical Features for Endocarditis

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Drugs & Therapeutics for Endocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endocarditis

Drug clinical trials:

Search ClinicalTrials for Endocarditis

Search NIH Clinical Center for Endocarditis

Search CenterWatch for Endocarditis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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32MalaCards
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MalaCards organs/tissues related to Endocarditis:

32
Heart, Skin, Lung, Testes, Colon, Kidney, Brain, Liver, Spleen, T cells, Endothelial, Thyroid, Prostate, Breast, Myeloid, Monocytes, Bone

Animal Models for Endocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9AQP9, PRTN3, PRF1, EPX, CYTIP, DLL1

Publications for Endocarditis

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50PubMed
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Articles related to Endocarditis:

(show top 50)    (show all 1758)
idTitleAuthorsYear
1
Prosthetic valve selection in patients with left-sided endocarditis: bioprosthetic or mechanical valves? (24419210)
2014
2
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. (24341951)
2013
3
Infective endocarditis giving rise to peritonitis in a patient on peritoneal dialysis. (23843595)
2013
4
Predominant role of host proteases in myocardial damage associated with infectious endocarditis induced by Enterococcus faecalis in a rat model. (23478315)
2013
5
Nonbacterial thrombotic endocarditis leading to acute heart failure due to aortic stenosis in a patient with lung cancer. (23857096)
2013
6
Rupture of a pacemaker lead during the course of infective endocarditis. (23518939)
2013
7
Tattooing complicated by multivalvular bacterial endocarditis. (23880943)
2013
8
Reverse-vaccinology strategy for designing T-cell epitope candidates for Staphylococcus aureus endocarditis vaccine. (23582120)
2013
9
Aorto-right atrial and right ventricular fistulae: a very rare complication of native bicuspid aortic valve endocarditis. (23850932)
2013
10
Pacemaker pocket displacement as a symptom of lead dependent infective endocarditis. (24297754)
2013
11
Long-term survival of dialysis patients with bacterial endocarditis undergoing valvular replacement surgery in the United States. (23785002)
2013
12
(18)FDG-positron emission tomography (PET) has a role to play in the diagnosis and therapy of infective endocarditis and cardiac device infection. (23313465)
2013
13
Staphylococcus aureus mitral valve endocarditis due to heel decubitus ulcer. (22669924)
2012
14
Infective endocarditis in the pediatric patient: a 60-year single-institution review. (22766082)
2012
15
A case of indolent endocarditis. (23997783)
2012
16
Impact of early surgical treatment on postoperative neurologic outcome for active infective endocarditis complicated by cerebral infarction. (22704800)
2012
17
The chance finding of echocardiographic complications of infective endocarditis. (22552172)
2012
18
Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. (22535857)
2012
19
An unusual case of pacemaker endocarditis in a patient with antiphospholipid syndrome. (22425342)
2012
20
Surgical treatment for infective endocarditis in elderly patients. (21679726)
2011
21
Recent progress in the understanding of infective endocarditis. (21922184)
2011
22
A Japanese case of proteinase 3 antineutrophil cytoplasmic autoantibody-associated pauci-immune-type crescentic glomerulonephritis without valvular endocarditis. (21331743)
2011
23
Infective endocarditis due to Aspergillus following kidney transplantation. (21895775)
2011
24
Anti-thrombotic therapy in infective endocarditis. (21932963)
2011
25
Loeffler endocarditis: findings on magnetic resonance imaging. (21687129)
2009
26
Methicillin-resistant Staphylococcus aureus (MRSA) mitral valve acute bacterial endocarditis (ABE) in a patient with Job's syndrome (hyperimmunoglobulin E syndrome) successfully treated with linezolid and high-dose daptomycin. (18206530)
2008
27
Loeffler endocarditis: what have we learned? (17573694)
2007
28
Embolic Risk in Subacute Bacterial Endocarditis: Determinants and Role of Transesophageal Echocardiography. (15963327)
2005
29
Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesis. (16113327)
2005
30
Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus Endocarditis unresponsive to vancomycin therapy with linezolid. (15119370)
2004
31
Splenic abscess associated with active infective endocarditis. (12478868)
2002
32
Infective endocarditis associated with fiberoptic bronchoscopy in a patient with mitral-valve prolapse. (9524866)
1998
33
Generalized pustular psoriasis associated with bacterial endocarditis of the anterior papillary muscle. (1390153)
1992
34
Renal arteriovenous fistula in the setting of subacute bacterial endocarditis. (2797534)
1989
35
Adult onset still's disease complicated by endocarditis with fatal evolution. (2612125)
1989
36
Endogenous orbital cellulitis and endogenous endophthalmitis in subacute bacterial endocarditis. (2787962)
1989
37
Endocarditis due to six entrapped pacemaker leads and concomitant recurrent coronary arteriosclerosis. (2981002)
1988
38
Amnesia as a presenting symptom in subacute bacterial endocarditis. (3722136)
1986
39
Subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans. (6356918)
1983
40
Subacute bacterial endocarditis. (1045304)
1976
41
LAPffler's endocarditis and endomyocardial fibrosis. Pathological aspects. (1228569)
1975
42
Subacute bacterial endocarditis. (5008021)
1972
43
The immune complex glomerulonephritis of bacterial endocarditis. (4550571)
1972
44
SUBACUTE BACTERIAL ENDOCARDITIS COMPLICATING PATENT DUCTUS ARTERIOSUS IN THE AGED. (14174586)
1964
45
Antimicrobial activity of penicillin V and phenethicillin with special reference to organisms isolated from 17 patients with subacute bacterial endocarditis. (13880717)
1962
46
A CASE of subacute bacterial endocarditis. (13629145)
1959
47
Combined antibiotic therapy in subacute bacterial endocarditis. (13135789)
1954
48
Rupture of spleen in subacute bacterial endocarditis: mycotic aneurysm of splenic artery and spontaneous rupture of spleen in subacute bacterial endocarditis. (13137635)
1954
49
Massive cerebral hemorrhage following heparin therapy in subacute bacterial endocarditis; report of two cases with a review of the literature. (15394693)
1949
50
An unusual strain of streptococcus isolated from subacute bacterial endocarditis. (18891618)
1948

Genetic Variations for Endocarditis

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Expression for genes affiliated with Endocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endocarditis

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Pathways for genes affiliated with Endocarditis

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Compounds for genes affiliated with Endocarditis

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44Novoseek, 24HMDB
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Compounds related to Endocarditis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1superoxide44 2411.9CFP, EPX, PRF1, PRTN3, LBP, CS
2serine4410.8CS, LBP, PRTN3, EPX, FCGR2A, LACTB
3lipid4410.7FCGR2A, LECT1, EPX, PRTN3, LBP, CS
4fmlp4410.7PRTN3, EPX, FCGR2A, CEACAM8
5histidine4410.5GTF3A, FCGR2A, PRF1, CS
6p0024410.3CS, PRTN3, EPX

GO Terms for genes affiliated with Endocarditis

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Products for genes affiliated with Endocarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet