Aliases & Classifications for Endocarditis

Aliases & Descriptions for Endocarditis:

Name: Endocarditis 12 52 41 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD10 33 I33.9
ICD9CM 35 421.9
MeSH 42 D004696

Summaries for Endocarditis

MedlinePlus : 41 endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards based summary : Endocarditis is related to lupus erythematosus and hepatitis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Cefazolin and Dextrose USP and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

Wikipedia : 71 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 591)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 29.9 CRP IL6 SERPINC1 TNNI3
2 hepatitis 29.8 IL10 IL6 TNF
3 aortic coarctation 29.8 IL6 TLR2 TNF
4 pericarditis 29.7 ALB APOH CRP SERPINC1 VCAM1
5 tuberculosis 29.5 IL10 IL6 PIK3C2A TNF TNNI3
6 bacterial meningitis 29.4 ALB CRP F2 IL6 TNF
7 central retinal artery occlusion 29.4 APOH F2 SERPINC1
8 capillary hemangioma 29.3 ALB F2 SERPINC1
9 allergic bronchopulmonary aspergillosis 29.3 ALB CRP CXCL8 IL6
10 calcinosis 29.3 ALB CRP IL6 TNF
11 peroneal neuropathy 29.3 ALB CRP IL6 TNF
12 neuropathy 29.2 CRP CXCL8 IL6 TNF
13 limb ischemia 29.2 CRP CXCL8 IL6 TNF
14 pulmonary tuberculosis 29.1 CXCL8 IL10 IL6 TNF
15 myocardial infarction 29.0 ALB CRP F2 IL10 IL6 PIK3C2A
16 membranoproliferative glomerulonephritis 28.7 ALB APOH CRP F2 IL10 IL6
17 pyelonephritis 28.6 CRP CXCL8 F2 IL10 PIK3C2A SERPINC1
18 rheumatoid arthritis 28.6 CRP CXCL8 HSPD1 IL10 IL6 TLR2
19 infective endocarditis 12.4
20 subacute bacterial endocarditis 12.4
21 marantic endocarditis 12.3
22 loeffler endocarditis 12.2
23 brucellosis 11.1
24 orthostatic intolerance 10.9
25 phaeohyphomycosis 10.7
26 erysipeloid 10.7
27 actinobacillosis 10.7
28 bartonellosis 10.7
29 haverhill fever 10.7
30 mitral valve prolapse, myxomatous 2 10.7
31 acute infection of pinna 10.4 CRP F2
32 nondystrophic myotonia 10.4 ALB F2
33 congenital dyserythropoietic anemia 10.4 ALB TNF
34 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
35 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
36 swine influenza 10.3 CRP IL6 TNF
37 human immunodeficiency virus infectious disease 10.3 CRP IL6 TNF
38 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.3 APOH F2 IL6
39 joint disorders 10.3 CRP IL6 TNF
40 midline cystocele 10.3 CRP F2 SERPINC1
41 benign neonatal seizures 10.3 CRP IL6 TNF
42 vascular erectile tumor 10.3 APOH F2 SERPINC1
43 may-hegglin anomaly 10.3 APOH F2 SERPINC1
44 left-right axis malformations 10.3 APOH F2 SERPINC1
45 lymphocytic colitis 10.3 APOH F2 SERPINC1
46 spinal cord lipoma 10.3 APOH F2 SERPINC1
47 neuroaxonal dystrophy 10.3 F2 IL6 SERPINC1
48 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
49 bullous skin disease 10.3 APOH F2 SERPINC1
50 lynch syndrome 10.3 APOH F2 SERPINC1

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Endocarditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 IL10 IL6 LBP PIK3C2A SERPINC1 TLR2
2 cardiovascular system MP:0005385 10.07 TNF TNNI3 VCAM1 CRP F2 IL10
3 homeostasis/metabolism MP:0005376 10.07 ALB APOH AQP9 CRP F2 IL10
4 immune system MP:0005387 9.97 AQP9 CRP EPX F2 FCGR2A IL10
5 liver/biliary system MP:0005370 9.5 ALB IL10 IL6 LBP SERPINC1 TLR2
6 mortality/aging MP:0010768 9.44 SERPINC1 TLR2 TNF TNNI3 VCAM1 ALB

Drugs & Therapeutics for Endocarditis

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cefazolin and Dextrose USP 17 CEFAZOLIN SODIUM B Braun Medical Approved July 2000

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fosfomycin Approved Phase 4 23155-02-4 446987
2
Imipenem Approved Phase 4 74431-23-5 104838
3
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
4
Rifampin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
5
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
6
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
7
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
8
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Hexetidine Approved Phase 4 141-94-6
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
13
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
14
Cephalexin Approved, Vet_approved Phase 4 15686-71-2 27447
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
16 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2
18 Antitubercular Agents Phase 4,Phase 3,Phase 2
19 methicillin Phase 4,Phase 3,Phase 2
20 Anesthetics Phase 4,Phase 2
21 Anesthetics, Local Phase 4,Phase 2
22 Anti-Arrhythmia Agents Phase 4,Phase 2
23 Central Nervous System Depressants Phase 4,Phase 2
24 Diuretics, Potassium Sparing Phase 4,Phase 2
25 Peripheral Nervous System Agents Phase 4,Phase 2
26 Sodium Channel Blockers Phase 4,Phase 2
27 beta-Lactams Phase 4
28 Lactams Phase 4
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
31 Fluoroquinolones Phase 4,Phase 3
32 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
33 Renal Agents Phase 4,Phase 3
34 Topoisomerase Inhibitors Phase 4,Phase 3
35 Adrenergic Agents Phase 4
36 Adrenergic Agonists Phase 4
37 Adrenergic alpha-Agonists Phase 4
38 Adrenergic beta-Agonists Phase 4
39 Anti-Asthmatic Agents Phase 4
40 Anti-Infective Agents, Local Phase 4
41 Autonomic Agents Phase 4
42 Bronchodilator Agents Phase 4
43 Chlorhexidine gluconate Phase 4
44 Dermatologic Agents Phase 4
45 Disinfectants Phase 4
46 Epinephryl borate Phase 4
47 Mydriatics Phase 4
48 Neurotransmitter Agents Phase 4
49 Pharmaceutical Solutions Phase 4
50 Racepinephrine Phase 4

Interventional clinical trials:

(show top 50) (show all 101)
id Name Status NCT ID Phase
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Partial Oral Treatment of Endocarditis Unknown status NCT01375257 Phase 4
3 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Unknown status NCT00871104 Phase 4
4 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4
5 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
6 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
7 Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia Completed NCT00548002 Phase 4
8 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4
9 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4
10 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Recruiting NCT01920126 Phase 4
11 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4
12 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Not yet recruiting NCT03112356 Phase 4
13 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4
14 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4
15 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4
16 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4
17 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4
18 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3
19 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3
20 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3
21 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3
22 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3
23 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Recruiting NCT02208063 Phase 3
24 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3
25 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Not yet recruiting NCT03138733 Phase 3
26 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2
27 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2
28 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
29 CopenHeart IE - Integrated Rehabilitation of Patients Treated for Infective Endocarditis Recruiting NCT01512615 Phase 2
30 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
31 Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia Recruiting NCT03163446 Phase 2
32 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis Not yet recruiting NCT03148756 Phase 2
33 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Terminated NCT00695903 Phase 2
34 Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia Terminated NCT01975662 Phase 2
35 Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF) Recruiting NCT02806882 Phase 1
36 Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
37 Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis Unknown status NCT02033421
38 Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients Unknown status NCT00562653
39 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
40 Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections Unknown status NCT01301638
41 PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
42 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
43 Positron Emission Tomography of Infection and Vasculitis Unknown status NCT01878721
44 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
45 Transapical Implantation of Ventor Embracer™ Valve in Patients With Severe Aortic Valve Disease Unknown status NCT00677638
46 Pivotal Study of a Percutaneous Mitral Valve Repair System Unknown status NCT00209274
47 IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis Completed NCT00144885
48 Outcomes Following Medical or Surgical Management of Endocarditis Completed NCT00166023
49 18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis Completed NCT02287792
50 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism Completed NCT00947817

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

39
Heart, Skin, Lung, Testes, Brain, Colon, Kidney

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 2051)
id Title Authors Year
1
Clinical utility of (18)F-FDG positron emission tomography/computed tomography scan vs. (99m)Tc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. ( 28050751 )
2017
2
Retrospective Examination of Q Fever Endocarditis: An Underdiagnosed Disease in the Mainland of China. ( 28051025 )
2017
3
Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. ( 28065906 )
2017
4
Bacteria endocarditis consolidation with vertebra bone tuberculosis: a case report. ( 28061897 )
2017
5
Infective endocarditis and risk of death after cardiac implantable electronic device implantation: a nationwide cohort study. ( 28073883 )
2017
6
Infective endocarditis prophylaxis: a review. ( 28076699 )
2017
7
Evolution of Prognosis inA Left-Sided Infective Endocarditis: A Propensity Score Analysis of 2 Decades. ( 28057237 )
2017
8
A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis. ( 28064105 )
2017
9
When the heart rules the head: ischaemic stroke and intracerebral haemorrhage complicating infective endocarditis. ( 28049738 )
2017
10
Propionibacterium acnes endocarditis: a case series. ( 28057559 )
2017
11
Fatal fungal endocarditis in a patient with primary antibody deficiency. ( 28062657 )
2017
12
Prognostic value of N-terminal prohormone brain natriuretic peptide for in-hospital and long-term outcomes in patients with infective endocarditis. ( 28067531 )
2017
13
First reported case of disseminated Nocardia kroppenstedtii sp nov. infection presenting with brain abscess and endocarditis in an immunocompromised patient with mantle cell lymphoma: challenges in diagnosis and treatment. ( 28062425 )
2017
14
A risk factor analysis for in-hospital mortality after surgery for infective endocarditis and a proposal of a new predictive scoring system. ( 28054252 )
2017
15
Effect of perioperative sodium bicarbonate administration on renal function following cardiac surgery for infective endocarditis: a randomized, placebo-controlled trial. ( 28057030 )
2017
16
International guideline changes and the incidence of infective endocarditis: a systematic review. ( 27621836 )
2016
17
Left main occlusion secondary to infective endocarditis vegetation: "The unusual suspect". ( 28063812 )
2016
18
A Rare Case of Fatal Endocarditis and Sepsis Caused by Pseudomonas aeruginosa in a Patient with Chronic Renal Failure. ( 27630891 )
2016
19
Metastatic Calcinosis of Aortic Valve Secondary to Renal Failure Mimicking Infective Endocarditis. ( 27738529 )
2016
20
Recurrent prosthetic mitral valve infective endocarditis and perivalvular abscess: first description by PET/CT angiography. ( 27178270 )
2016
21
The first case of chronic Q fever endocarditis and aortitis from Turkey: A 5-year infection before diagnosis with drain in sternum. ( 27723671 )
2016
22
Infective endocarditis following Melody valve implantation: comparison with a surgical cohort. ( 27161361 )
2016
23
Meticillin-resistant Staphylococcus aureus endocarditis: first report of daptomycin plus ceftobiprole combination as salvage therapy. ( 27211210 )
2016
24
Predisposing cardiac conditions, interventional procedures, and antibiotic prophylaxis among patients with infective endocarditis. ( 27595678 )
2016
25
Managing infective endocarditis in the elderly: new issues for an old disease. ( 27621607 )
2016
26
Early degeneration and endocarditis in a trans-catheter heart valve. ( 27161610 )
2016
27
Aspergillus prosthetic valve endocarditis. ( 27165628 )
2016
28
Morbidity and mortality of infective endocarditis in a hospital system in New York City serving a diverse urban population. ( 27206447 )
2016
29
Multiple cerebral artery occlusion due to non-bacterial thrombotic endocarditis: an autopsy case report. ( 26960272 )
2016
30
What's new in surgical treatment of infective endocarditis? ( 27663580 )
2016
31
Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease. ( 27818810 )
2016
32
Ruptured Sinus of Valsalva with Infective Endocarditis Complicated with Post-Infectious Acute Glomerulonephritis: A Rare Case Presentation. ( 27891383 )
2016
33
Infective Endocarditis With Paravalvular Extension: 35-Year Experience. ( 27207394 )
2016
34
Infective endocarditis as a rare cause for acute limb ischemia. ( 27547285 )
2016
35
Use of Dithiothreitol to Dislodge Bacteria From the Biofilm on an Aortic Valve in the Operating Theatre: A Case of Infective Endocarditis Caused by Staphylococcus aureus and Proteus mirabilis. ( 27645982 )
2016
36
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis. ( 27871078 )
2016
37
Infective endocarditis of an aorto-right atrial fistula caused by asymptomatic rupture of a sinus of Valsalva aneurysm: a case report. ( 27180251 )
2016
38
Right-sided Infective Endocarditis in an Indian Intensive Care Unit. ( 27621564 )
2016
39
Ventricular Septal Defect from Aortic Regurgitation Jet Lesion in Aortic Valve Infective Endocarditis. ( 27989057 )
2016
40
Haemophilus parainfluenzae endocarditis with systemic embolisation following maxillary sinusitis. ( 27599807 )
2016
41
Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature. ( 27885316 )
2016
42
Large vegetation secondary to native mitral valve infective endocarditis in child. ( 27130493 )
2016
43
Intermittent High-Grade Atrioventricular Block in a Man With Infective Endocarditis. ( 27087175 )
2016
44
Pauci-immune crescentic glomerulonephritis without ANCA in a patient presenting with Candida parapsilosis endocarditis. ( 26897307 )
2016
45
Does type of prosthesis affect long-term outcomes after aortic valve replacement for infective endocarditis? How should we properly answer this question? ( 27993368 )
2016
46
Subacute Bacterial Endocarditis with Leptotrichia goodfellowii in a Patient with a Valvular Allograft: A Case Report and Review of the Literature. ( 27895947 )
2016
47
Reconstruction of a Previously Repaired Aortic Valve Destroyed by Infective Endocarditis: Case Report. ( 27162188 )
2016
48
The Effect of Antibiotic Prophylaxis Guidelines on Incidence of Infective Endocarditis. ( 27160964 )
2016
49
An unusual case of Corynebacterium striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease. ( 27751312 )
2016
50
Hypereosinophilic Syndrome: A Case of Fatal LAPffler Endocarditis. ( 26904305 )
2016

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 CXCL8 IL10 IL6 LBP TLR2 TNF
2
Show member pathways
12.82 CXCL8 EPX HSPD1 IL10 IL6 TNF
3
Show member pathways
12.29 CXCL8 IL6 TLR2 TNF
4
Show member pathways
12.28 ALB CRP F2 IL6 TNF
5
Show member pathways
12.23 CXCL8 IL6 TLR2 TNF
6
Show member pathways
12.23 CXCL8 IL6 LBP TNF
7
Show member pathways
12.22 FCGR2A IL10 TLR2 TNF
8
Show member pathways
12.14 CXCL8 IL6 LBP TLR2 TNF
9
Show member pathways
12.13 CXCL8 IL10 IL6 TNF
10 12.1 CXCL8 HSPD1 IL10 IL6 TNF
11 12.05 ALB IL6 TNNI3 VCAM1
12 11.98 CXCL8 FCGR2A IL6 TNF
13 11.95 FCGR2A HSPD1 IL10 IL6 LBP TLR2
14 11.92 CEACAM8 FCGR2A IL10 IL6 TNF
15
Show member pathways
11.91 IL10 IL6 TLR2 TNF
16 11.87 CXCL8 IL6 TNF VCAM1
17 11.85 CXCL8 LBP TNF VCAM1
18 11.81 CXCL8 IL6 TLR2 TNF
19 11.79 CXCL8 IL10 IL6 LBP TNF VCAM1
20 11.78 CXCL8 IL10 IL6 TLR2 TNF
21 11.72 IL10 IL6 TNF
22 11.72 CXCL8 IL10 IL6 TNF
23 11.63 CXCL8 IL6 TNF
24
Show member pathways
11.61 CXCL8 IL6 TNF VCAM1
25 11.47 CXCL8 IL10 IL6 TNF
26 11.46 CXCL8 HSPD1 IL6 TLR2 TNF
27 11.33 IL10 IL6 TNF
28 11.28 IL10 IL6 TNF VCAM1
29 11.28 FCGR2A IL10 IL6 TLR2 TNF VCAM1
30 11.24 IL10 IL6 TNF
31 11.17 CXCL8 IL10 IL6 TNF
32 10.95 CRP CXCL8 IL6 TNF
33 10.79 CXCL8 IL10 IL6 TLR2 TNF VCAM1

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ALB APOH CRP CXCL8 EPX F2
2 cell surface GO:0009986 9.73 APOH HSPD1 LBP TLR2 TNF VCAM1
3 extracellular exosome GO:0070062 9.73 ALB APOH CEACAM8 CRP EPX F2
4 extracellular space GO:0005615 9.47 ALB APOH CEACAM8 CRP CXCL8 EPX

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 AQP9 CEACAM8 CXCL8 IL10 IL6 TLR2
2 cellular protein metabolic process GO:0044267 9.92 ALB F2 IL6 SERPINC1
3 response to organic substance GO:0010033 9.85 AQP9 HSPD1 IL10 TNF
4 response to glucocorticoid GO:0051384 9.81 HSPD1 IL10 IL6 TNF
5 response to insulin GO:0032868 9.79 IL10 IL6 TLR2
6 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 IL10 IL6 LBP TNF
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 LBP TLR2 TNF
8 positive regulation of interleukin-8 production GO:0032757 9.73 LBP TLR2 TNF
9 response to lipopolysaccharide GO:0032496 9.73 HSPD1 IL10 IL6 LBP TLR2 VCAM1
10 regulation of blood coagulation GO:0030193 9.71 APOH F2 SERPINC1
11 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 LBP TNF
12 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 IL10 TLR2
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 TNF
14 negative regulation of fibrinolysis GO:0051918 9.63 APOH F2
15 positive regulation of macrophage activation GO:0043032 9.63 HSPD1 IL10 LBP
16 acute-phase response GO:0006953 9.62 CRP F2 IL6 LBP
17 opsonization GO:0008228 9.61 CRP LBP
18 cellular response to lipoteichoic acid GO:0071223 9.61 LBP TLR2
19 endothelial cell apoptotic process GO:0072577 9.6 IL10 TNF
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 IL10 TNF
21 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
22 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
23 negative regulation of lipid storage GO:0010888 9.58 CRP IL6 TNF
24 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP TLR2 TNF
25 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
26 positive regulation of interleukin-6 production GO:0032755 9.02 HSPD1 IL6 LBP TLR2 TNF
27 inflammatory response GO:0006954 10 CRP CXCL8 IL10 IL6 TLR2 TNF

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL10 IL6 TNF
2 lipopeptide binding GO:0071723 9.16 LBP TLR2
3 lipopolysaccharide binding GO:0001530 8.92 F2 HSPD1 LBP TLR2

Sources for Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....