Endocarditis malady

MedlinePlus: Endocarditis is an inflammation of your heart's inner lining. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve a severe case of mitral valve prolapse an artificial heart valve certain heart defects if you have a high risk of bacterial endocarditis, your doctor might prescribe antibiotics before dental work and certain types of surgery. early treatment can help you avoid complications. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin and weight loss. treatment usually involves high-dose antibiotics.²³

MalaCards: Endocarditis is related to infective endocarditis and subacute bacterial endocarditis. An important gene associated with Endocarditis is LECT1 (leukocyte cell derived chemotaxin 1), and among its related pathways are Glycolysis and gluconeogenesis (short map) and Glycolysis and gluconeogenesis (short map). The drugs amikacin sulfate and gentamicin sulfate pwdr [va product] and the compounds abciximab and tirofiban have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and monocytes, and related mouse phenotypes are hematopoietic system and integument.

Disease Ontology: A heart disease involving non-infectious inflammation of the endocardium (inner layer of the heart).⁶

Wikipedia: Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves...⁴⁴ more...

Aliases & Descriptions:

endocarditis 6 8 32 23 43

Diseases related to endocarditis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 641)

id	Related Disease	Score	Top Affiliating Genes
1	infective endocarditis	35.8	CFP, MKL1, DNAJA2, PRTN3
2	subacute bacterial endocarditis	34.6	CFP, DNAJA2, PRTN3
3	q fever	29.5	SELE, LNX2, CD14, CD40LG, APOH, MBL2
4	microscopic polyangiitis	27.8	SELE, FCGR2A, F2, TNF, TNFRSF1B, CRP
5	antiphospholipid syndrome	26.3	VWF, SELE, SERPINC1, VCAM1, CD40LG, ITGB3
6	pulmonary embolism	26.1	PIK3C2A, SERPINC1, APOH, FAM155B, IFNA2, F5
7	kawasaki disease	25.8	VWF, SELE, SERPINA1, VCAM1, CD14, CD40LG
8	congestive heart failure	23.8	PIK3C2A, VWF, SELE, LMNA, MUC16, CD40LG
9	glomerulonephritis	21.9	VWF, SERPINC1, SERPINH1, VCAM1, LMNA, LAP3
10	thrombosis	21.8	PIK3C2A, VWF, SELE, SERPINC1, SERPINA1, VCAM1
11	nephrotic syndrome	21.3	PIK3C2A, VWF, GC, SELE, SERPINC1, SERPINA1
12	cerebritis	19.2	PIK3C2A, VWF, GC, SELE, SERPINC1, SERPINA1
13	anemia	18.8	VWF, SELE, SERPINC1, VCAM1, LMNA, RAN
14	peripheral vertigo	14.2	SERPINC1, APOH, F2, CRP
15	neisseria meningitidis infection	14.2	LACTB, CFP, FCGR2A, MBL2
16	bacterial meningitis	14.1	PIK3C2A, CKB, LBP, LACTB, CFP, CRP
17	bernard-soulier syndrome	14.0	VWF, ITGB3, F2, NEU1
18	autoimmune thrombocytopenic purpura	14.0	VWF, ITGB3, FCGR2A, PF4
19	appendicitis	14.0	LGALS1, LACTB, CRP
20	bacteremia, protection against	13.9	LBP, LACTB, MBL2, CAT, CRP
21	collagenous colitis	13.9	CD40LG, APOH, RNASE3, EPX
22	antithrombin iii deficiency	13.9	SERPINC1, APOH, F5, F2, F10
23	afibrinogenemia	13.9	VWF, CFP, F5, F2, F10
24	factor xii deficiency	13.9	VWF, SERPINC1, APOH, F5, F2
25	factor viii deficiency	13.9	VWF, SERPINC1, F5, F2, F10
26	glanzmann's thrombasthenia	13.9	VWF, ITGB3, FN1, F10, PF4
27	paroxysmal nocturnal hemoglobinuria	13.9	VWF, CEACAM8, CD14, ANXA5, F10, EPO
28	ischemic optic neuropathy	13.9	ITGB3, APOH, F5, F2, CRP
29	prothrombin deficiency	13.9	SERPINC1, APOH, F5, F2
30	spinal cord infarction	13.9	SERPINC1, APOH, F5, F2
31	intracranial thrombosis	13.8	VWF, SERPINC1, APOH, F5
32	placental infarction	13.8	SERPINC1, APOH, F5
33	hematuria	13.8	PIK3C2A, CFP, CD40LG, FN1, F10, COL6A2
34	protein c deficiency	13.8	SERPINC1, CFP, APOH, F5, F2, PF4
35	hemorrhagic disease	13.8	VWF, SERPINC1, F5, F2, F10, PF4
36	sneddon syndrome	13.8	SERPINC1, APOH, F5, F2, PF4
37	factor vii deficiency	13.8	SERPINC1, F5, F2, F10
38	reactive arthritis	13.7	LBP, HSPD1, CRP, PRTN3
39	acquired von willebrand syndrome	13.7	VWF, CD40LG, F2
40	thrombasthenia	13.7	VWF, ITGB3, FN1, GTF3A, F5, F2
41	hepatic vein thrombosis	13.7	SERPINC1, APOH, F5
42	polyarteritis nodosa	13.7	CD40LG, APOH, IFNA2, CRP, PRTN3
43	maculopathy	13.7	VWF, SELE, CKB, HTRA1, CRP
44	placental abruption	13.7	SERPINC1, SERPINH1, LGALS1, APOH, F5, F2
45	bronchitis	13.7	SERPINA1, LACTB, IGHE, RNASE3, PRTN3
46	hemophilia b	13.7	VWF, F2, F10, PF4
47	sycp3-related pregnancy loss, susceptibility to	13.6	SERPINC1, CD40LG, APOH, ANXA5, F5, F2
48	collagen disease	13.6	VWF, APOH, MBL2, TNF, CRP
49	catastrophic antiphospholipid syndrome	13.6	CD40LG, APOH, F5, CRLS1
50	duchenne muscular dystrophy	13.6	PIK3C2A, CKB, LAP3, F2, HSPD1, TNNI3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amikacin, amikacin sulfate, gentamicin, gentamicin sulfate, gentamicin sulfate pwdr [va product]

MalaCards organs/tissues related to endocarditis:

²²

MGI Mouse Phenotypes related to endocarditis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.3	OTC, CYTIP, PLCB2, EPO, EPX, GAPDH
2	integument phenotype	MP:0010771	9.2	PLCB2, PHB, KRT1, KRT10, HBB, NSDHL
3	skeleton phenotype	MP:0005390	9.0	AKR1A1, TNFRSF1B, PTH1R, DLL1, PLAT, HBB
4	renal/urinary system phenotype	MP:0005367	9.0	GAPDH, LYN, PRDX6, HBB, ACTN4, OTC
5	immune system phenotype	MP:0005387	8.3	WDR1, VWF, LMNA, KHSRP, LGALS1, LECT1
6	growth/size phenotype	MP:0005378	7.8	PDIA3, PFN2, PHB, PLAT, OTC, DLL1
7	cardiovascular system phenotype	MP:0005385	7.0	CRP, PPIA, DLL1, TNNI3, TNFRSF1B, TNF
8	mortality/aging	MP:0010768	7.0	OTC, ODC1, PPIA, PLAT, PHB, DLL1
9	homeostasis/metabolism phenotype	MP:0005376	3.2	KRT1, GAPDH, EPO, LYN, NEU1, ACTC1

Articles related to endocarditis:

(show top 50)    (show all 58)

id	Title	Authors	Year	Affiliating Genes
1	Platelet receptor polymorphisms do not influence Stap hylococcus aureus-platelet interactions or infective endocarditis. (21044892)	Daga S.... Fitzgerald J.R.	2010	ITGB3, FCGR2A
2	Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: data from a randomized trial of patients with bacteremia and endocarditis. (20462352)	Bhavnani S.M.... Drusano G.L.	2010	PIK3C2A
3	The transcriptional programme of human heart valves r eveals the natural history of infective endocarditis. (20126625)	Benoit M.... Mege J.L.	2010	AQP9
4	Current status of the management of pediatric infect ive endocarditis: a national survey (19951491)	Chen S.B.	2009	LACTB
5	Successful management of multiple permanent pacemaker complications--infection, 13 year old silent lead perforation and exteriorisation following failed percutaneous extraction, superior vena cava obstruction, tricuspid valve endocarditis, pulmonary embolism and prosthetic tricuspid valve thrombosis. (19239701)	Kaul P.... Baig W.	2009	PLAT
6	Patients with infective endocarditis and increased cardiac troponin I levels have a higher incidence of in-hospital mortality and valve replacement than those with normal cardiac troponin I levels. (18682663)	Tsenovoy P.... Kopacz M.S.	2009	TNNI3
7	Recurrent multi-focal cerebral stroke complicating L ibman-Sacks endocarditis in a young woman with systemic lupus erythromatosus (19253190)	JedliA8ski I.... Zawilska K.	2009	F5, APOH
8	Revisiting Libman-Sacks endocarditis: a historical re view and update. (19089657)	Lee J.L.... Gershwin M.E.	2009	F2, PLCB2, CRLS1
9	Lipopolysaccharide-binding protein: a new biomarker for infectious endocarditis? (18832474)	Vollmer T.... Dreier J.	2009	LBP
10	Stabilized infective endocarditis and altered heparin responsiveness during cardiopulmonary bypass. (19597879)	Na S.... Kwak Y.L.	2009	SERPINC1
11	Libman-Sacks endocarditis and cerebral embolization i n antiphospholipid syndrome. (18267921)	LA... Gerdts E.	2008	APOH
12	Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy. (18371509)	Krol V.... Cunha B.A.	2008	CD40LG
13	Libman-Sacks endocarditis in systemic lupus erythemat osus: prevalence, associations, and evolution. (17602939)	Moyssakis I.... Moutsopoulos H.M.	2007	APOH
14	Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. (17393025)	Heying R.... Beekhuizen H.	2007	GTF3A
15	Disseminated intravascular clotting associated with F c-receptor IIa-mediated platelet activation in a patient with endocarditis afte r aortic valve replacement. (16914467)	Kottenberg-Assenmacher E.... Peters J.	2006	PF4
16	Interleukin 1alpha increases the susceptibility of rabbits to experimental viridans streptococcal endocarditis. (16428739)	Dankert J.... Zaat S.A.	2006	IL1A
17	Mitral valve thrombosis and infective endocarditis in a patient with prothrombin mutation. (17205928)	GA1llA1lA1 S.... Ozdemir B.	2006	F2
18	Fatal mitral valve endocarditis by Erysipelothrix rh usiopathiae (16178460)	Vallespi G.V.... Lopardo H.A.	2005	CAT
19	Normalization of cancer antigen 125 after mitral valve replacement in a patient with congestive heart failure due to mitral valve endocarditis. (16200889)	Sugishita H.... Shikata F.	2005	MUC16
20	Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesis. (16113327)	Paik S.... Kitten T.	2005	ADSL
21	Primary antiphospholipid syndrome and factor V Leiden mutation in a young patient with non-bacterial thrombotic endocarditis and transient ischemic stroke. (16411415)	Letsas K.P.... Kardaras F.	2005	F5
22	Diagnosis, treatment, and long-term management of Kaw asaki disease: a statement for health professionals from the Committee on Rheum atic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Diseas e in the Young, American Heart Association. (15505111)	Newburger J.W.... .	2004	TNF
23	Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. (15297484)	Avidor B.... Giladi M.	2004	CS, HTRA1
24	Necrotizing glomerulonephritis caused by Bartonella henselae endocarditis. (14750122)	Bookman I.... Herzenberg A.M.	2004	CD40LG
25	Anti-clumping factor A immunoglobulin reduces the duration of methicillin-resistant Staphylococcus aureus bacteremia in an experimental model of infective endocarditis. (14576094)	Vernachio J.... Patti J.M.	2003	GTF3A
26	Streptococcus sinensis sp. nov., a novel species isolated from a patient with infective endocarditis. (11880397)	Woo P.C.... Yuen K.Y.	2002	ODC1
27	Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis. (11771532)	Hellmich B.... Schatz H.	2001	PRTN3
28	The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)	Ghigo E.... Mege J.	2000	TNFRSF1B
29	Expression of endothelial cell adhesion molecules on heart valves: up-regulation in degeneration as well as acute endocarditis. (10767719)	MA1ller A.M.... Kirkpatrick C.J.	2000	SELE, VCAM1
30	Candida endocarditis in association with myelodysplas tic syndromes: review of the literature and report of a case. (17312671)	Otaki M.... Oku H.	1999	IL3
31	The level of erythropoietin in serum of patients with anemia during infective endocarditis (10723224)	KraA9nik L.... Paradowski S.	1999	EPO
32	The presence of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) in the course of subacute bacterial endocarditis with glomerular involvement, coincidence or association? (9491280)	Subra J.F.... Chevailler A.	1998	PRTN3
33	LAPffler's parietal fibroplastic endocarditis. Echoca rdiographic course over 5 years (9072488)	Metzler B.... Hust M.H.	1997	IFNA2
34	Candida endocarditis in a child with hyperimmunoglobulinemia E syndrome. (9215244)	Yates A.B.... Moffitt J.E.	1997	IGHE
35	Nephrotic syndrome associated with subacute bacterial endocarditis (SBE): a case report. (7570680)	Yamauchi F.... Koide S.	1994	CFP
36	Aminoglycoside resistant enterococcal endocarditis. (8463648)	Eliopoulos G.M.	1993	LACTB
37	A case of infective endocarditis in which a new vegetation appeared on a different site during chemotherapy (8351441)	Inomata T.... Shibata A.	1993	CRP
38	Mechanisms of platelet aggregation by Streptococcus s anguis, a causative organism in infective endocarditis. (8338784)	Ford I.... Hampton K.K.	1993	VWF
39	Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. (8323254)	Greene J.N.... Sinnott J.T.	1993	LACTB
40	Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. (8444668)	Thal L.A.... Zervos M.J.	1993	LACTB
41	Endocarditis caused by Kingella denitrificans. (8308323)	Hassan I.J.... Hayek L.	1993	LACTB
42	The Enterococcus endocarditis model in experimental a nimals and its relevance to human infection. (8335527)	Gutschik E.	1993	LACTB
43	Acquired bisalbuminemia in staphylococcal endocarditi s treated with dicloxacillin. (1287818)	Winter V.... von Essen R.	1992	ALB
44	Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. (1602151)	Dawson S.J.... White L.A.	1992	CA2, PGK1, MAPK9
45	Overview of viridans streptococcal endocarditis: clinical analysis of 99 cases. (1659935)	Chao C.H.... Hu B.S.	1991	CRP
46	Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. (1778210)	Munz D.L.... Emrich D.	1991	CEACAM8
47	Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. (1985118)	Slungaard A.... Mahoney J.R.	1991	EPX
48	Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. (2050588)	Catherall E.J.... Mizen L.W.	1991	LACTB
49	Infective endocarditis, rheumatoid factor, and anticardiolipin antibodies. (2317111)	Asherson R.A.... Hughes G.R.	1990	APOH
50	Neurologic complications of late prosthetic valve endocarditis. (2309273)	Keyser D.L.... Adams H.P.	1990	F2

Genes related to endocarditis according to GeneCards:

(show top 50)    (show all 163)

id	Symbol	Description	Score	GeneCards Section Context
1	LECT1	leukocyte cell derived chemotaxin 1	11.0
2	PRTN3	proteinase 3	11.0	Publications
3	CFP	complement factor properdin	11.0	Publications
4	DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	11.0
5	GTF3A	general transcription factor IIIA	11.0	Publications
6	LACTB	lactamase, beta	11.0	Publications
7	MKL1	megakaryoblastic leukemia (translocation) 1	11.0
8	AMDHD2	amidohydrolase domain containing 2	11.0
9	CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	11.0	Publications
10	CYTIP	cytohesin 1 interacting protein	11.0
11	SRA1	steroid receptor RNA activator 1	11.0
12	DLL1	delta-like 1 (Drosophila)	11.0
13	AQP9	aquaporin 9	11.0	Publications
14	TNNI3	troponin I type 3 (cardiac)	11.0	Publications
15	LBP	lipopolysaccharide binding protein	11.0	Publications
16	EPX	eosinophil peroxidase	11.0	Publications
17	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
18	CS	citrate synthase	11.0	Publications
19	C1QBP	complement component 1, q subcomponent binding protein	11.0
20	ODC1	ornithine decarboxylase 1	11.0	Publications
21	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
22	PRF1	perforin 1 (pore forming protein)	11.0
23	NEU1	sialidase 1 (lysosomal sialidase)	11.0
24	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
25	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
26	RNASE3	ribonuclease, RNase A family, 3	11.0
27	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
28	F10	coagulation factor X	11.0
29	F2	coagulation factor II (thrombin)	11.0	Publications
30	EPO	erythropoietin	11.0	Publications
31	VWF	von Willebrand factor	11.0	Publications
32	CRP	C-reactive protein, pentraxin-related	11.0	Publications
33	FGL2	fibrinogen-like 2	10.9	Publications
34	IFNA14	interferon, alpha 14	10.9	Publications
35	FBXL15	F-box and leucine-rich repeat protein 15	10.9	Disorders
36	HSPB6	heat shock protein, alpha-crystallin-related, B6	10.9	Publications
37	C14orf166	chromosome 14 open reading frame 166	10.9	Publications
38	PFN2	profilin 2	10.9	Publications
39	AP3M2	adaptor-related protein complex 3, mu 2 subunit	10.9	Publications
40	PRPS2	phosphoribosyl pyrophosphate synthetase 2	10.9	Publications
41	ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	10.9	Publications
42	CRLS1	cardiolipin synthase 1	10.9	Publications
43	GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	10.9	Publications
44	SELENBP1	selenium binding protein 1	10.9	Publications
45	FAM155B	family with sequence similarity 155, member B	10.9	Disorders
46	SUMF2	sulfatase modifying factor 2	10.9
47	SMAGP	small cell adhesion glycoprotein	10.9
48	GATAD1	GATA zinc finger domain containing 1	10.9
49	KHSRP	KH-type splicing regulatory protein	10.9	Publications
50	HSPH1	heat shock 105kDa/110kDa protein 1	10.9	Publications

Pathways related to endocarditis according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Glycolysis and gluconeogenesis (short map)10	10.4	GAPDH, PGK1, PKLR, TPI1, ALDOA, ENO1
2	Glycolysis and gluconeogenesis (short map)41	10.4	GAPDH, PGK1, PKLR, TPI1, ALDOA, ENO1
3	Cytoskeleton remodeling Neurofilaments10	10.4	GFAP, ACTG1, TUBB2A, TUBA1C, CAPZA2, CAPZA1
4	Glycolysis38	10.4	GAPDH, PGK1, TPI1, ALDOA, ENO1
5	Glycolysis / Gluconeogenesis20	10.3	GAPDH, PGM1, PGK1, PKLR, TPI1, AKR1A1
6	Cytoskeleton remodeling_Neurofilaments41	10.3	GFAP, ACTG1, TUBB2A, TUBA1C, CAPZA2, CAPZA1
7	Phagosome20	10.3	TUBB2A, TUBA1C, MBL2, FCGR2A, ITGB3, CD14
8	Blood Coagulation Signaling Pathways37	10.2	PLAT, F10, F2, F5, SERPINC1, VWF
9	Extrinsic Prothrombin Activation Pathway36	10.2	F10, F2, F5, SERPINC1
10	Complement and coagulation cascades20	10.1	PLAT, F10, F2, F5, MBL2, SERPINA1
11	Metabolic pathways20	9.8	PIK3C2A, PKLR, NDUFS3, ACO2, PRDX6, PRPS2
12	Asthma20	9.4	EPX, RNASE3, TNF, IL3, CD40LG
13	African trypanosomiasis20	9.2	HBB, PLCB2, TNF, APOA1, VCAM1, SELE
14	Tuberculosis20	9.1	TNF, HSPD1, IFNA2, IFNA14, MAPK9, IL1A
15	Selected targets of HNF110	8.9	CRP, ALB, APOH, APOA1, SERPINA1
16	Cytokine Network36	8.7	TNF, IFNA2, IFNA14, IL3, IL1A

Compounds related to endocarditis according to GeneDecks:

(show top 50)    (show all 313)

id	Compound	Score	Top Affiliating Genes
1	abciximab32 9 9	12.2	VWF, CD40LG, FCGR2A, ANXA5, F2, F10
2	tirofiban32 9 9	12.1	VWF, SERPINC1, CD40LG, ITGB3, ANXA5, F2
3	pyruvate32	10.0	PIK3C2A, VDAC1, CKB, MDH2, ALDOA, HSPA5
4	ivig32	9.9	PIK3C2A, VWF, GTF3A, IL3, CRP
5	citrate32	9.9	PIK3C2A, VDAC1, MDH2, F10, HSPB1, CAT
6	phosphatidylserine32 9 9	11.8	VWF, SELE, LGALS1, CD14, MBL2, ANXA1
7	malate32	9.7	VDAC1, LAP3, MDH2, ANXA1, ANXA2, HSPD1
8	glucose32	9.6	LGALS1, CKB, MUC16, LAP3, GTF3A, AQP9
9	carbohydrates32	9.5	SELE, VCAM1, LGALS1, CD209, CD14, MBL2
10	n acetylcysteine32	9.0	VWF, SELE, SERPINC1, VCAM1, IL3, ANXA5
11	oxygen32 18	10.0	PIK3C2A, SERPINA1, VDAC1, RAN, LGALS1, CKB
12	polyethylene glycol32	9.0	SELE, SERPINC1, VDAC1, FN1, APOA1, IFNA2
13	nitric oxide32 9 18 9	11.9	SELE, SERPINH1, SERPINA1, VDAC1, VCAM1, LBP
14	glyceraldehyde 3-phosphate32	8.8	VDAC1, LGALS1, CKB, MDH2, ENO1, ANXA1
15	aspartate32	8.7	PIK3C2A, GC, KHSRP, CKB, LBP, LAP3
16	glutamate32	8.7	GC, VDAC1, LAP3, KAT2B, MDH2, APOH
17	heparin32 9 18 9	11.7	PIK3C2A, VWF, SERPINA1, LGALS1, LBP, CFP
18	h2o232	8.6	VWF, SERPINA1, VDAC1, RAN, MUC16, LAP3
19	dextran sulfate32	8.5	SELE, SERPINC1, VDAC1, CFP, CD40LG, FN1
20	polyacrylamide32	8.4	GC, SERPINH1, SERPINA1, LGALS1, LBP, CD14
21	estrogen32	8.3	VWF, GC, SERPINC1, SERPINA1, CKB, ITGB3
22	steroid32	8.2	PIK3C2A, GC, VDAC1, CKB, MUC16, KAT2B
23	fmlp32	8.1	GC, VCAM1, CEACAM8, CD14, FN1, FCGR2A
24	atp32	8.0	PIK3C2A, SERPINH1, VDAC1, VCP, LMNA, RAN
25	homocysteine32 18	8.8	PIK3C2A, VWF, SELE, SERPINC1, VCAM1, LBP
26	calcium32 9 18 9	10.8	PIK3C2A, VWF, VDAC1, VCP, LMNA, LGALS1
27	ascorbic acid32 18	8.8	SERPINH1, CFP, CD40LG, IL1A, IL3, ANXA5
28	phosphatidylcholine32	7.7	SELE, VDAC1, VCAM1, LBP, FN1, IL1A
29	arginine32	7.7	PIK3C2A, VWF, SERPINC1, RAN, LGALS1, LAP3
30	prednisolone32 9 9	9.6	PIK3C2A, VWF, VCAM1, MUC16, CD14, FCGR2A
31	cysteine32	7.4	SERPINA1, VDAC1, RAN, LGALS1, LAP3, CD14
32	adenylate32	7.3	VWF, GC, SELE, SERPINC1, VDAC1, VCAM1
33	superoxide32 18	8.3	PIK3C2A, GC, VCAM1, VCP, RAN, LGALS1
34	iron32 18	8.2	PIK3C2A, SERPINA1, VDAC1, MUC16, LAP3, ITGB3
35	polysaccharide32	7.2	SELE, SERPINC1, SERPINA1, VDAC1, VCAM1, VCP
36	cyclosporin a32 42	8.1	PIK3C2A, VWF, SERPINH1, VDAC1, CD14, FN1
37	tyrosine32	6.8	PIK3C2A, SH3BP5, VWF, SERPINH1, SERPINA1, VDAC1
38	glutamine32	6.7	VWF, VDAC1, VCP, LGALS1, CKB, CD14
39	cycloheximide32	6.5	SELE, CKB, LBP, CD14, FN1, IL1A
40	fibrinogen32	6.5	PIK3C2A, GC, SELE, SERPINC1, SERPINA1, VCAM1
41	dexamethasone32 42 34 9 9	10.5	VWF, SERPINC1, VCAM1, LGALS1, MUC16, LBP
42	cholesterol32 9 18 9	9.4	PIK3C2A, VWF, GC, SELE, SERPINA1, VCAM1
43	histamine32 18	7.2	VWF, SELE, VCAM1, CD14, CD40LG, FCGR2A
44	vegf32	6.1	PIK3C2A, VWF, SELE, SERPINC1, SERPINH1, VCAM1
45	lipid32	5.6	PIK3C2A, GC, SELE, SERPINA1, VDAC1, VCAM1
46	alanine32	5.2	PIK3C2A, VWF, SELE, SERPINC1, VCAM1, LMNA
47	retinoic acid32 42 18	6.8	VWF, GC, VCAM1, LMNA, LAP3, KAT2B
48	creatinine32	4.4	PIK3C2A, VWF, GC, SELE, SERPINC1, SERPINA1
49	serine32	4.3	VWF, GC, SELE, SERPINC1, SERPINH1, SERPINA1
50	lactate32	4.3	PIK3C2A, VWF, SELE, VDAC1, VCAM1, CKB

Cellular components related to endocarditis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:042470	10.0	PDIA6, PDIA3, HSPA5, ANXA2, ANXA11, ITGB3
2	extracellular matrix	GO:031012	9.9	PRTN3, COL6A2, PLAT, HTRA1, ANXA2, APOH
3	mitochondrial matrix	GO:005759	9.9	ECHS1, CS, ACO2, C1QBP, OTC, HSPD1
4	endoplasmic reticulum lumen	GO:005788	9.9	PDIA6, PDIA3, COL6A2, SUMF2, HSPA5, F10
5	platelet alpha granule lumen	GO:031093	9.0	ACTN4, PF4, ALDOA, ALB, F5, FN1
6	cell surface	GO:009986	8.3	HSPD1, HMMR, TNF, PLAT, PEBP1, HSPB1
7	cytosol	GO:005829	7.1	ACTG1, ACTC1, PKLR, RPS6KA2, RPLP0, PLCB2
8	plasma membrane	GO:005886	7.1	PTH1R, TNFRSF1B, TNF, HMMR, CAT, HSPB1
9	cytoplasm	GO:005737	6.9	CYTIP, SRA1, PLAT, PLXDC1, RPLP0, PTH1R
10	extracellular region	GO:005576	6.2	PPIA, DLL1, TNFRSF1B, CAPZA2, CAPZA1, HSPH1
11	extracellular space	GO:005615	5.2	EPO, IFNA2, F5, HTRA1, F2, ALB

Biological processes related to endocarditis according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation, intrinsic pathway	GO:007597	10.8	C1QBP, F10, F2, APOH, VWF
2	acute-phase response	GO:006953	10.5	CRP, F2, MBL2, APCS, FN1, LBP
3	gluconeogenesis	GO:006094	10.4	GAPDH, PGK1, TPI1, ALDOA, ENO1, MDH2
4	glycolysis	GO:006096	10.3	GAPDH, PGK1, PKLR, TPI1, ALDOA, ENO1
5	protein folding	GO:006457	10.3	TCP1, DNAJA2, PDIA6, PDIA3, PPIA, TUBB2A
6	carbohydrate metabolic process	GO:005975	10.3	PKLR, CS, PGK1, PGM1, GAPDH, TPI1
7	hydrogen peroxide catabolic process	GO:042744	10.0	CAT, HBB, PRDX6, EPX
8	glucose metabolic process	GO:006006	9.8	GAPDH, PGM1, PGK1, PKLR, TNF, TPI1
9	response to organic cyclic compound	GO:014070	9.7	LYN, PEBP1, PSMB2, PKLR, ANXA1, IL1A
10	negative regulation of lipid storage	GO:010888	9.7	CRP, TNF, ITGB3
11	virus-host interaction	GO:019048	9.7	RPLP0, C1QBP, C14orf166, PSMB2, PSMC2, LYN
12	innate immune response	GO:045087	9.2	LYN, RPS6KA2, CAPZA2, CAPZA1, IFNA2, IFNA14
13	anti-apoptosis	GO:006916	9.1	EPO, TNF, GLO1, HSPB1, HSPA5, ANXA1
14	response to hypoxia	GO:001666	8.9	ADSL, ACTN4, PKLR, PLAT, CRP, TNF
15	small molecule metabolic process	GO:044281	8.2	PSMC2, PSMB2, HBB, ACO2, NDUFS3, PKLR
16	platelet degranulation	GO:002576	8.0	LYN, SERPINA1, VWF, WDR1, ITGB3, FN1
17	platelet activation	GO:030168	7.8	ALDOA, HSPA5, PPIA, PF4, ACTN4, TF
18	blood coagulation	GO:007596	7.0	LYN, TF, HBB, ACTN4, ACTG1, C1QBP

Molecular functions related to endocarditis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	10.2	EPO, ANXA5, MBL2, APOH, ATP5A1, ATP5B
2	unfolded protein binding	GO:051082	10.1	DNAJA2, PPIA, HSPD1, HSPA5, CCT6A, APCS
3	ATPase activity	GO:016887	9.5	RUVBL1, PSMC2, ACTC1, HSPD1, HSPA5, ATP5A1
4	protein binding	GO:005515	3.7	GAPDH, PFN2, PHB, COL6A2, RPLP0, PLXDC1