Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 72 51 40 41 14 69 59


External Ids:

Disease Ontology 12 DOID:10314
ICD10 32 I33.9
ICD9CM 34 421.9
MeSH 41 D004696

Summaries for Endocarditis

MedlinePlus : 40 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to infective endocarditis and brucellosis, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Allograft rejection and Toll-like receptor signaling pathway. The drugs Cefazolin and Dextrose USP and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 59
About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE).The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection.IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications.IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 72 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 623)
# Related Disease Score Top Affiliating Genes
1 infective endocarditis 32.2 APOH CRP F2 FCGR2A IL6 LBP
2 brucellosis 31.8 CRP CXCL8 IL10 IL6 TNF
3 bacteremia 2 30.9 CRP LACTB LBP
4 pericarditis 30.7 CRP IL6 TNF
5 q fever 30.4 IL10 TLR2 TNF
6 mycobacterium fortuitum 30.4 CXCL8 HSPD1 LACTB
7 ischemic heart disease 30.2 CRP IL6 TNF
8 temporal arteritis 30.2 APOH CRP IL6
9 cellulitis 30.2 CRP LACTB TNF
10 cardiogenic shock 30.2 CRP IL6 PIK3C2A
11 antiphospholipid syndrome 30.1 APOH F2 SERPINC1
12 myocarditis 30.0 IL6 TNF TNNI3
13 microscopic polyangiitis 29.9 IL10 TNF
14 spondylitis 29.9 CRP IL6 TNF
15 osteomyelitis 29.9 CXCL8 IL10 IL6 TNF
16 end stage renal failure 29.9 ALB CRP IL6 TNF
17 disseminated intravascular coagulation 29.9 F2 PIK3C2A SERPINC1
18 pericardial effusion 29.8 CRP IL6 PIK3C2A
19 patent foramen ovale 29.8 APOH F2 SERPINC1
20 adult-onset still's disease 29.8 CRP FCGR2A IL6 TNF
21 vasculitis 29.8 APOH CRP TNF VCAM1
22 arthritis 29.8 CXCL8 IL10 IL6 TNF
23 polyarteritis nodosa 29.8 APOH CRP IL6
24 stroke, ischemic 29.8 APOH CRP F2 SERPINC1
25 purpura 29.8 APOH CRP F2 SERPINC1 TNF
26 limb ischemia 29.7 IL6 TNF TNNI3
27 thrombosis 29.7 APOH F2 SERPINC1
28 retinal artery occlusion 29.7 APOH F2 SERPINC1
29 prostatitis 29.7 CXCL8 IL10 IL6 TNF
30 protein s deficiency 29.7 APOH F2 SERPINC1
31 meconium aspiration syndrome 29.6 CXCL8 IL6 TNF
32 mycobacterium chelonae 29.6 CXCL8 TLR2
33 acquired immunodeficiency syndrome 29.6 ALB IL10 IL6 TNF
34 crohn's disease 29.5 CRP IL10 IL6 TNF
35 acute myocardial infarction 29.5 CRP PIK3C2A SERPINC1 TNNI3
36 compartment syndrome 29.5 ALB F2 PIK3C2A TNF
37 hypersplenism 29.5 ALB F2 SERPINC1
38 mycobacterium abscessus 29.5 CXCL8 TLR2 TNF
39 thrombophlebitis 29.5 APOH F2 SERPINC1
40 septic arthritis 29.4 CRP CXCL8 TLR2
41 pulmonary embolism 29.4 ALB APOH CRP F2 SERPINC1 TNNI3
42 lymphadenitis 29.4 CXCL8 IL10 TNF
43 severe hemophilia a 29.4 F2 FCGR2A IL10 TNF
44 heparin-induced thrombocytopenia 29.4 FCGR2A SERPINC1
45 wegener granulomatosis 29.3 CRP CXCL8 IL10 IL6 TNF
46 homocysteinemia 29.3 ALB CRP F2 SERPINC1
47 haemophilus influenzae 29.3 CXCL8 TLR2 TNF
48 kawasaki disease 29.3 ALB CRP FCGR2A HSPD1 IL10 IL6
49 sickle cell anemia 29.3 F2 TNF VCAM1
50 autoimmune myocarditis 29.3 TNF VCAM1

Graphical network of the top 20 diseases related to Endocarditis:

Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:

edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Endocarditis:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 VCAM1 TLR2 FCGR2A TNF IL10 IL6
2 cardiovascular system MP:0005385 10.02 VCAM1 F2 TLR2 TNF IL10 TNNI3
3 homeostasis/metabolism MP:0005376 9.97 VCAM1 TLR2 TNF IL10 IL6 ALB
4 immune system MP:0005387 9.77 VCAM1 TLR2 FCGR2A TNF IL10 IL6
5 mortality/aging MP:0010768 9.44 VCAM1 F2 FCGR2A TLR2 HSPD1 TNF

Drugs & Therapeutics for Endocarditis

PubMedHealth treatment related to Endocarditis: 59

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery.

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
Cefazolin and Dextrose USP 17 CEFAZOLIN SODIUM B Braun Medical July 2000

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Fosfomycin Approved Phase 4 23155-02-4 446987
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 14969 441141
Rifampin Approved Phase 4,Phase 3 13292-46-1 5381226 5458213
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Hexetidine Approved, Investigational Phase 4 141-94-6
12 Racepinephrine Approved Phase 4 329-65-7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
16 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2
19 methicillin Phase 4,Phase 3,Phase 2
20 Anesthetics Phase 4,Phase 2
21 Anesthetics, Local Phase 4,Phase 2
22 Anti-Arrhythmia Agents Phase 4,Phase 2
23 Central Nervous System Depressants Phase 4,Phase 2
24 Diuretics, Potassium Sparing Phase 4,Phase 2
25 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
26 Sodium Channel Blockers Phase 4,Phase 2
27 beta-Lactams Phase 4
28 Lactams Phase 4
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
31 Fluoroquinolones Phase 4,Phase 3
32 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
33 Renal Agents Phase 4,Phase 3
34 Topoisomerase Inhibitors Phase 4,Phase 3
35 Adrenergic Agents Phase 4
36 Adrenergic Agonists Phase 4
37 Adrenergic alpha-Agonists Phase 4
38 Adrenergic beta-Agonists Phase 4
39 Anti-Asthmatic Agents Phase 4
40 Anti-Infective Agents, Local Phase 4
41 Autonomic Agents Phase 4,Phase 3
42 Bronchodilator Agents Phase 4
43 Chlorhexidine gluconate Phase 4
44 Dermatologic Agents Phase 4
45 Disinfectants Phase 4
46 Epinephryl borate Phase 4
47 Mydriatics Phase 4
48 Neurotransmitter Agents Phase 4
49 Pharmaceutical Solutions Phase 4
50 Respiratory System Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 125)

# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Unknown status NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
3 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4 Vancomycin
4 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
5 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
6 Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia Completed NCT00548002 Phase 4 trovafloxacin and levofloxacin
7 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
8 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
9 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
10 Partial Oral Treatment of Endocarditis Recruiting NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
11 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Recruiting NCT01920126 Phase 4 sodium bicarbonate;Saline
12 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
13 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
14 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4 Daptomycin
15 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
16 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
17 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
18 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
19 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
20 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
21 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
22 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
23 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Recruiting NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
24 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
25 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
26 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Not yet recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
27 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
28 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
29 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
30 CopenHeart IE - Integrated Rehabilitation of Patients Treated for Infective Endocarditis Recruiting NCT01512615 Phase 2
31 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
32 Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia Recruiting NCT03163446 Phase 2 Placebo
33 Neonatal Vancomycin Trial Recruiting NCT02790996 Phase 2 Vancomycin
34 Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation Not yet recruiting NCT03381989 Phase 1, Phase 2
35 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
36 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
37 Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
38 Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF) Recruiting NCT02806882 Phase 1 Ceftaroline fosamil
39 Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis Unknown status NCT02033421
40 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005
41 Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
42 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
43 Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients Unknown status NCT00562653
44 Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections Unknown status NCT01301638
45 PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
46 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
47 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
48 Transapical Implantation of Ventor Embracer™ Valve in Patients With Severe Aortic Valve Disease Unknown status NCT00677638
49 Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis Completed NCT02940340
50 Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008) Completed NCT03295045

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 69 / NDF-RT 47 :

Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

Heart, Skin, Lung, Testes, Brain, Endothelial, Liver

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 2162)
# Title Authors Year
Corrigendum to "A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE". [Int. J. Cardiol. Aug 15 2017;241:97-102.]. ( 29398138 )
Emphysematous endocarditis caused by AmpC beta-lactamase-producing Escherichia coli: A case report. ( 29419663 )
Bioprosthetic Versus Mechanical Valve Replacement for Infective Endocarditis: Focus on Recurrence Rates. ( 29452115 )
Marseille scoring system for empiric treatment of infective endocarditis. ( 29397446 )
Acquired ventricular septal defect due to infective endocarditis. ( 29440841 )
The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review. ( 29413230 )
Bioprosthetic Versus Mechanical Valve Replacement for Endocarditis: Focus on Recurrence Rates (Commentary). ( 29452116 )
Primary percutaneous coronary intervention during ST elevation myocardial infarction in prosthetic valve endocarditis: a case report. ( 29426281 )
A broad-range PCR technique for the diagnosis of infective endocarditis. ( 29429763 )
Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis. ( 29450741 )
Gemella bergeri infective endocarditis: a case report and brief review of literature. ( 29444729 )
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. ( 29390976 )
A Review of Combination Antimicrobial Therapy for Enterococcus Faecalis Bloodstream Infections and Infective Endocarditis. ( 29390132 )
What are the main predictors of in-hospital mortality in patients with infective endocarditis: a review. ( 29382232 )
Current knowledge among Japanese experienced general dentists regarding prevention of infective endocarditis. ( 29435864 )
Outcomes of Reoperative Valve Replacement in Patients with Prosthetic Valve Endocarditis: A 20-Year Experience. ( 29430424 )
Infective endocarditis in a patient with metastatic colorectal cancer. ( 29390605 )
Nonbacterial Thrombotic Endocarditis Presenting with Leg Pain and a Left Atrial Mass Lesion. ( 29448257 )
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
Does antibiotic prophylaxis really prevent streptococci infective endocarditis? ( 29378813 )
Endocarditis after transcatheter aortic valve implantation: a current assessment. ( 29434627 )
Q fever endocarditis after right ventricle to pulmonary artery conduit insertion: Case series and review of the literature. ( 29440832 )
Lessons learned from splenic infarcts with fever of unknown origin (FUO): culture-negative endocarditis (CNE) or malignancy? ( 29417312 )
Outcome of Infective Endocarditis in the Current Era: Early Predictors of Poor Prognosis. ( 29382606 )
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
Prognostic implications of a negative echocardiography in patients with infective endocarditis. ( 29409744 )
Hemolytic anemia due to native valve subacute endocarditis with<i>Actinomyces israelii</i>infection. ( 29445480 )
Efficacy and Safety of Fosfomycin Plus Imipenem vs. Vancomycin for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Randomized Clinical Trial. ( 29408610 )
A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE. ( 29408350 )
Problems in anticoagulation of a patient with antibiotic treatment for endocarditis: interaction of rifampicin and vitamin K antagonists. ( 29440136 )
Prosthetic Valve Infective Endocarditis With Mycobacterium Fortuitum: Antibiotics Alone Can Be Curative. ( 28688832 )
Infective endocarditis, embolic stroke and splenic abscess: a case report. ( 29423161 )
Fatal fungal endocarditis in a patient with primary antibody deficiency. ( 28062657 )
Infective endocarditis causing mitral valve stenosis - a rare but deadly complication: a case report. ( 28209176 )
Infective endocarditis prophylaxis: a review. ( 28076699 )
Effect of perioperative sodium bicarbonate administration on renal function following cardiac surgery for infective endocarditis: a randomized, placebo-controlled trial. ( 28057030 )
Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report. ( 29284415 )
Cutaneous vasculitis: a presentation with endocarditis to keep in mind. ( 28954130 )
Marantic endocarditis and paraneoplastic pulmonary embolism. ( 28710195 )
A risk factor analysis for in-hospital mortality after surgery for infective endocarditis and a proposal of a new predictive scoring system. ( 28054252 )
Acalculous cholecystitis in a female with cardiac device-related infective endocarditis. ( 28987045 )
Sternoclavicular joint osteomyelitis extending to lung abscess complicated by Staphylococcal infective endocarditis. ( 28660126 )
Geotrichum candidum in Infective Endocarditis. ( 28878529 )
In silico assessment of virulence factors in strains of Streptococcus oralis and Streptococcus mitis isolated from patients with Infective Endocarditis. ( 28874232 )
Bacteria endocarditis consolidation with vertebra bone tuberculosis: a case report. ( 28061897 )
A chronic hemodialysis patient with isolated pulmonary valve infective endocarditis caused by non-albicans Candida: a rare case and literature review. ( 28874131 )
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ( 28890659 )
Infective endocarditis and thoracic aortic disease: A review on forgotten psychological aspects. ( 28824792 )
Analysis of Short- and Long-term Outcomes of Patients With Surgically Treated Left-sided Infective Endocarditis: A 5-Year Longitudinal Follow-up Study. ( 28935512 )
Whipple's endocarditis presenting as ulnar artery aneurysm; if you don't look, you won't find. ( 28928251 )

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
12.29 CXCL8 IL6 TLR2 TNF
Show member pathways
12.29 ALB CRP F2 IL6 TNF
Show member pathways
12.23 CXCL8 IL6 TLR2 TNF
Show member pathways
Show member pathways
12.22 FCGR2A IL10 TLR2 TNF
Show member pathways
Show member pathways
12.13 CXCL8 IL10 IL6 TNF
10 12.12 CXCL8 HSPD1 IL10 IL6 TNF
11 12.05 ALB IL6 TNNI3 VCAM1
12 11.99 CXCL8 FCGR2A IL6 TNF
13 11.95 FCGR2A HSPD1 IL10 IL6 LBP TLR2
14 11.92 CEACAM8 FCGR2A IL10 IL6 TNF
Show member pathways
11.91 IL10 IL6 TLR2 TNF
16 11.88 CXCL8 IL6 TNF VCAM1
17 11.85 CXCL8 LBP TNF VCAM1
18 11.82 CXCL8 IL6 TLR2 TNF
19 11.79 CXCL8 IL10 IL6 LBP TNF VCAM1
Show member pathways
11.78 CRP IL6 LBP
21 11.78 CXCL8 IL10 IL6 TLR2 TNF
22 11.77 CXCL8 IL6 LBP
23 11.73 CXCL8 IL10 IL6 TNF
24 11.7 IL10 IL6 TNF
Show member pathways
26 11.63 CXCL8 IL6 TNF
27 11.47 CXCL8 IL10 IL6 TNF
28 11.46 CXCL8 HSPD1 IL6 TLR2 TNF
29 11.34 IL10 IL6 TNF
30 11.28 IL10 IL6 TNF VCAM1
31 11.25 IL10 IL6 TNF
32 11.25 FCGR2A IL10 IL6 TLR2 TNF VCAM1
33 11.17 CXCL8 IL10 IL6 TNF
34 10.95 CRP CXCL8 IL6 TNF
35 10.79 CXCL8 IL10 IL6 TLR2 TNF VCAM1

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ALB APOH CRP CXCL8 EPX F2
2 cell surface GO:0009986 9.73 APOH HSPD1 LBP TLR2 TNF VCAM1
3 extracellular exosome GO:0070062 9.73 ALB APOH CEACAM8 CRP EPX F2
4 extracellular space GO:0005615 9.47 ALB APOH CEACAM8 CRP CXCL8 EPX

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 CRP CXCL8 IL10 IL6 TLR2 TNF
2 immune response GO:0006955 9.95 AQP9 CEACAM8 CXCL8 IL10 IL6 TLR2
3 cellular protein metabolic process GO:0044267 9.91 ALB F2 IL6 SERPINC1
4 response to lipopolysaccharide GO:0032496 9.88 IL10 LBP TLR2 VCAM1
5 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.72 CXCL8 IL10 IL6 LBP TNF
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 LBP TLR2 TNF
8 positive regulation of interleukin-8 production GO:0032757 9.7 LBP TLR2 TNF
9 regulation of blood coagulation GO:0030193 9.69 APOH F2 SERPINC1
10 positive regulation of macrophage activation GO:0043032 9.65 HSPD1 IL10 LBP
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.63 IL10 LBP TNF
13 cellular response to lipoteichoic acid GO:0071223 9.62 LBP TLR2
14 negative regulation of fibrinolysis GO:0051918 9.62 APOH F2
15 response to molecule of bacterial origin GO:0002237 9.61 CXCL8 IL10 TLR2
16 opsonization GO:0008228 9.6 CRP LBP
17 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
18 negative regulation of cytokine secretion involved in immune response GO:0002740 9.57 IL10 TNF
19 positive regulation of STAT protein import into nucleus GO:2000366 9.56 F2 IL6
20 acute-phase response GO:0006953 9.56 CRP F2 IL6 LBP
21 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
22 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP TLR2 TNF
23 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
24 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
25 positive regulation of interleukin-6 production GO:0032755 9.02 HSPD1 IL6 LBP TLR2 TNF
26 regulation of receptor activity GO:0010469 10 CXCL8 F2 IL10 IL6 TNF

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL10 IL6 TNF
2 lipopeptide binding GO:0071723 9.16 LBP TLR2
3 lipopolysaccharide binding GO:0001530 8.92 F2 HSPD1 LBP TLR2

Sources for Endocarditis

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
51 Novoseek
54 OMIM via Orphanet
58 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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