MCID: END033
MIFTS: 48

Endocarditis malady

Summaries for Endocarditis

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MedlinePlus:32 Endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards based summary: Endocarditis is related to infective endocarditis and bacteremia. An important gene associated with Endocarditis is CFP (complement factor properdin), and among its related pathways are Cardiac Progenitor Differentiation and Striated Muscle Contraction. The drug gentamicin sulfate pwdr and the compounds abciximab and mannan have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

Wikipedia:63 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Aliases & Classifications for Endocarditis

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Endocarditis, Aliases & Descriptions:

Name: Endocarditis 9 11 43 32 60


External Ids:

Disease Ontology9 DOID:10314
MeSH33 D004696
NCIt38 C34582

Related Diseases for Endocarditis

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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 346)
idRelated DiseaseScoreTop Affiliating Genes
1infective endocarditis32.6LECT1
2bacteremia31.0LBP, MBL2
3glomerulonephritis30.9MBL2, FCGR2A, CFP
4rheumatic heart disease30.7LECT1, MBL2
5congestive heart failure30.7TNNT2, TNNI3
6bacterial meningitis30.4LBP, CFP
7myocardial infarction30.3LBP, GP1BA, TNNT2, TNNI3
8congenital heart disease30.3CS, TNNI3, TNNT2
9hypertrophic cardiomyopathy30.3TNNT2, TNNI3
10meningitis30.3LBP, CFP, FCGR2A, PRF1, MBL2
11myocarditis30.2TNNT2, TNNI3, PRF1
12pneumonia30.2MBL2, PRF1, EPX, LBP
13membranoproliferative glomerulonephritis30.1CFP, MBL2
14nephritis30.0FCGR2A, APOH, CFP
15heart valve disease30.0LECT1, APOH
16tuberculosis29.9MBL2, PRF1, EPX
17thrombocytopenia29.9GP1BA, APOH, FCGR2A
18systemic lupus erythematosus29.8CFP, APOH, FCGR2A, MBL2
19collagen disease29.8MBL2, APOH
20vascular disease29.7APOH, TNNI3, TNNT2
21behcet's disease29.5MBL2, APOH
22lupus nephritis29.5MBL2, FCGR2A, APOH
23rheumatoid arthritis29.4LBP, APOH, FCGR2A, MBL2
24subacute bacterial endocarditis11.2
25aneurysm10.7
26q fever10.7
27marantic endocarditis10.6
28cerebritis10.5
29loeffler endocarditis10.5
30rheumatic fever10.5
31ventricular septal defect10.5
32splenic abscess10.4
33aortitis10.4
34crescentic glomerulonephritis10.4
35hypereosinophilic syndrome10.4
36mycobacterium fortuitum10.4
37stenotrophomonas maltophilia10.3
38kawasaki disease10.3
39discitis10.3
40pericarditis10.3
41antiphospholipid syndrome10.3
42meningococcal meningitis10.3CFP, MBL2
43arthritis10.3
44gerbode defect10.3
45complement deficiency10.3MBL2, CFP
46tetralogy of fallot10.3
47patent ductus arteriosus10.3
48leukemia10.2
49epidural abscess10.2
50pulmonary embolism10.2

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to endocarditis

Symptoms for Endocarditis

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Drugs & Therapeutics for Endocarditis

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Drug clinical trials:

Search ClinicalTrials for Endocarditis

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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MalaCards organs/tissues related to Endocarditis:

31
Heart, Skin, Lung, Testes, Colon, Brain, Kidney, Spleen, Liver, Neutrophil, Thyroid, T cells, Endothelial, Prostate, Monocytes, Bone, Breast, Myeloid, B lymphoblasts

Animal Models for Endocarditis or affiliated genes

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MGI Mouse Phenotypes related to Endocarditis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.4CFP, LECT1, FCGR2A, EPX, PRF1, MBL2
2MP:00053977.0LBP, GP1BA, LECT1, FCGR2A, EPX, PRF1
3MP:00053766.7MBL2, LBP, CFP, GP1BA, LECT1, TNNT2

Publications for Endocarditis

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Articles related to Endocarditis:

(show top 50)    (show all 1846)
idTitleAuthorsYear
1
Acute Q fever and the risk of developing endocarditis. (25743166)
2015
2
Cervical epidural abscess: rare complication of bacterial endocarditis with streptococcus viridans: a case report. (25883665)
2015
3
Characteristics and natural history of patients with colorectal cancer complicated by infectious endocarditis. Case control study of 25 patients. (24403486)
2014
4
Surgical treatment for aortic periannular abscess/pseudoaneurysm caused by infective endocarditis. (23161575)
2013
5
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
6
The risk for bacterial endocarditis in cirrhotic patients: a population-based 3-year follow-up study. (23352807)
2013
7
Use of autologous pericardium for mitral leaflet reconstruction in a child with endocarditis. (23939329)
2013
8
CT angiography and A^a8,F-FDG-PET fusion imaging for prosthetic heart valve endocarditis. (24029372)
2013
9
Echocardiographic measurement of cardiac valvular thickness in healthy cows, cows with bacterial endocarditis, and cows with cardiorespiratory diseases. (24252809)
2013
10
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. (24341951)
2013
11
Left kidney infarction in a patient with native aortic valve infective endocarditis: diagnosis with contrast-enhanced ultrasound. (24432168)
2013
12
Comparison between early and late prosthetic valve endocarditis: clinical characteristics and outcomes. (24224422)
2013
13
Hairy cell leukemia masquerading as infective endocarditis. (24426343)
2013
14
Impact of haplotypes of TNF in the natural course of infective endocarditis. (24165416)
2013
15
Triple cusps replacement for active aortic endocarditis. (23557585)
2013
16
Infective endocarditis giving rise to peritonitis in a patient on peritoneal dialysis. (23843595)
2013
17
OPAT outcomes in endocarditis. (23615590)
2013
18
Cardiac device infective endocarditis and patient survival. (22910745)
2012
19
Staphylococcus aureus mitral valve endocarditis due to heel decubitus ulcer. (22669924)
2012
20
Clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. (23983869)
2012
21
Rapidly progressive glomerulonephritis associated with PR3-ANCA positive subacute bacterial endocarditis. (22989831)
2012
22
Timing for surgery in patients with infective endocarditis and cerebrovascular complications--waiting may be best but results of early surgery are acceptable and improvements in neurology are common. (22219446)
2012
23
Dentigenous infectious foci - a risk factor of infective endocarditis. (22293883)
2012
24
Endocarditis and myocarditis: a brief review. (23098151)
2012
25
Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels. (22302637)
2012
26
Recurrent Infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (e coli) after therapeutic ERCP. (22720314)
2012
27
Infective endocarditis and spondylodiscitis due to posterior nasal packing in a patient with a bioprosthetic aortic valve. (22447509)
2012
28
Coxiella burnetii endocarditis after Q fever vaccination. (22956746)
2012
29
Mycotic Celiac Artery Aneurysm Following Infective Endocarditis: Successful Treatment Using N-butyl Cyanoacrylate with Embolization Coils. (23555513)
2012
30
An atypical presentation of infective endocarditis. (23182295)
2012
31
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. (21963210)
2011
32
Successful combination therapy with vancomycin and arbekacin against infective endocarditis caused by MRSA. (22686009)
2011
33
Infective endocarditis in mitral mechanical prosthesis: the role of three-dimensional transoesophageal echocardiography. (21795251)
2011
34
Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. (18797945)
2009
35
Dual ANCA positivity in subacute bacterial endocarditis. (18431098)
2008
36
Gerbode type defect and third degree atrioventricular block in association with bacterial endocarditis in a dog. (19010115)
2008
37
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
38
Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. (16188499)
2005
39
The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)
2000
40
Disseminated Mycobacterium chelonae infection resulting in endocarditis. (8953086)
1996
41
Demonstration of microorganisms in subacute bacterial endocarditis. (7610438)
1995
42
Acquired bisalbuminemia in staphylococcal endocarditis treated with dicloxacillin. (1287818)
1992
43
Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. (1778210)
1991
44
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. (1985118)
1991
45
SUBACUTE BACTERIAL ENDOCARDITIS PRESENTING WITH HAEMOPERITONEUM FROM RUPTURED MYCOTIC ANEURYSM. (14252919)
1964
46
Subacute bacterial endocarditis. Clinical and laboratory observations in 27 consecutive cases treated with penicillin V by mouth. (13738726)
1961
47
Phagocytic reticuloendothelial cells in subacute bacterial endocarditis with negative cultures. (13852405)
1960
48
Subacute bacterial endocarditis; clinical and therapeutic considerations. (14382895)
1955
49
Bacteriostatic agents in the treatment of subacute bacterial endocarditis. (13126547)
1954
50
Experiences in the management of subacute bacterial endocarditis treated with penicillin. (18920942)
1948

Variations for Endocarditis

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Expression for genes affiliated with Endocarditis

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Search GEO for disease gene expression data for Endocarditis.

Pathways for genes affiliated with Endocarditis

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Pathways related to Endocarditis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TNNI3, TNNT2
2
Show member pathways
9.7TNNI3, TNNT2
3
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.6MBL2, CFP
49.4MBL2, FCGR2A

Compounds for genes affiliated with Endocarditis

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Sources:
43Novoseek, 12DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Endocarditis according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1abciximab43 1211.0GP1BA, FCGR2A
2mannan439.9MBL2, CFP
3rrna439.9GTF3A, CS
4methanol43 2410.8APOH, EPX
5ptca439.8TNNT2, APOH
6phosphorus439.8APOH, CFP
7polymyxin b439.8LBP, MBL2
8phosphatidylethanolamine43 1210.8APOH, LBP
9p002439.8CS, EPX, APOH
10phenylalanine439.8CS, FCGR2A, GP1BA
11adenine43 24 1211.7GTF3A, CS, GP1BA
12etanercept43 49 1211.6FCGR2A, APOH
13cytochalasin b439.6EPX, GP1BA
14prostacyclin439.6GP1BA, APOH, FCGR2A
15cardiolipin43 1210.6MBL2, APOH
16infliximab43 49 1211.5FCGR2A, APOH
17ivig439.4APOH, FCGR2A, GTF3A
18agarose439.4MBL2, EPX, APOH
19p003439.4APOH, CS, MBL2
20lipoteichoic acid439.4LBP, APOH, MBL2
21latex439.4MBL2, APOH, GP1BA
22phosphatidylserine43 28 1211.4MBL2, APOH, GP1BA
23aspartate439.3LBP, EPX, CS, MBL2
24histidine439.3GTF3A, CS, PRF1, FCGR2A
25ethanol43 49 24 1212.3APOH, CS, MBL2
26polysaccharide439.2LBP, CFP, FCGR2A, MBL2
27phospholipid439.2LBP, APOH, PRF1
28dexamethasone43 49 28 1212.2MBL2, CS, EPX, LBP
29phosphatidylinositol439.1LBP, GP1BA, APOH, FCGR2A
30mannose439.1CFP, APOH, FCGR2A, MBL2
31prednisolone43 28 1211.1MBL2, EPX, FCGR2A, APOH
32phosphatidylcholine439.0MBL2, PRF1, APOH, LBP
33alanine438.9LBP, GP1BA, TNNT2, CS, GTF3A
34steroid438.9APOH, EPX, MBL2, GTF3A
35nitric oxide43 24 1210.8LBP, APOH, EPX, CS, MBL2
36lactate438.8GP1BA, TNNT2, TNNI3, APOH, EPX, CS
37valine438.7GP1BA, APOH, FCGR2A, CS, MBL2
38fibrinogen438.6LBP, GP1BA, APOH, MBL2, GTF3A
39glucose438.6GP1BA, APOH, CS, MBL2, GTF3A
40atp43 289.5APOH, FCGR2A, CS, MBL2, GTF3A
41oxygen43 249.4LBP, APOH, FCGR2A, EPX, CS, MBL2
42tyrosine438.4LBP, GP1BA, FCGR2A, EPX, MBL2
43heparin43 28 24 1211.3LBP, CFP, GP1BA, TNNT2, APOH, FCGR2A
44cholesterol43 28 24 1211.3LBP, APOH, FCGR2A, PRF1, CS, MBL2
45vegf438.3GTF3A, MBL2, APOH, LECT1
46superoxide43 249.2MBL2, LBP, CFP, APOH, EPX, PRF1
47creatinine438.1LBP, TNNT2, TNNI3, APOH, EPX, CS
48serine437.7LBP, GP1BA, FCGR2A, EPX, PRF1, CS
49lipid437.6LBP, LECT1, APOH, FCGR2A, EPX, CS
50calcium43 49 24 1210.4GP1BA, TNNT2, TNNI3, APOH, FCGR2A, EPX

GO Terms for genes affiliated with Endocarditis

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Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00058619.6TNNI3, TNNT2
2sarcomereGO:00300179.4TNNI3, TNNT2
3extracellular regionGO:00055768.1MBL2, PRF1, LECT1, CFP, LBP

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:003278010.0TNNI3, TNNT2
2ventricular cardiac muscle tissue morphogenesisGO:00550109.9TNNI3, TNNT2
3blood coagulation, intrinsic pathwayGO:00075979.9GP1BA, APOH
4opsonizationGO:00082289.8MBL2, LBP
5cellular defense responseGO:00069689.8PRF1, LBP
6negative regulation of growth of symbiont in hostGO:00441309.7MBL2, LBP
7muscle filament slidingGO:00300499.7TNNT2, TNNI3
8defense response to Gram-positive bacteriumGO:00508309.6MBL2, LBP
9acute-phase responseGO:00069539.6MBL2, LBP
10complement activationGO:00069569.5MBL2, CFP
11negative regulation of endothelial cell proliferationGO:00019379.3APOH, LECT1
12innate immune responseGO:00450879.0LBP, CFP, FCGR2A, MBL2
13negative regulation of angiogenesisGO:00165258.8APOH, LECT1

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:00483069.6MBL2, TNNI3
2troponin C bindingGO:00301729.4TNNI3, TNNT2

Products for genes affiliated with Endocarditis

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Sources for Endocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet