MCID: END033
MIFTS: 57

Endocarditis malady

Cardiovascular diseases category
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Summaries for Endocarditis

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MedlinePlus:33 Endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards based summary: Endocarditis is related to infective endocarditis and bacteremia. An important gene associated with Endocarditis is CFP (complement factor properdin), and among its related pathways are Cardiac Progenitor Differentiation and Striated Muscle Contraction. The drug gentamicin sulfate pwdr and the compounds abciximab and mannan have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

Wikipedia:65 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Aliases & Classifications for Endocarditis

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Endocarditis, Aliases & Descriptions:

Name: Endocarditis 8 10 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:10314
MeSH34 D004696
NCIt39 C34582

Related Diseases for Endocarditis

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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1infective endocarditis32.6LECT1
2bacteremia31.0MBL2, LBP
3glomerulonephritis30.9FCGR2A, MBL2, CFP
4congestive heart failure30.7TNNT2, TNNI3
5myocardial infarction30.4TNNT2, TNNI3, GP1BA, LBP
6congenital heart disease30.3TNNT2, CS, TNNI3
7hypertrophic cardiomyopathy30.3TNNT2, TNNI3
8meningitis30.3LBP, PRF1, MBL2, CFP, FCGR2A
9pneumonia30.2LBP, EPX, PRF1, MBL2
10bacterial meningitis30.1CFP, LBP
11myocarditis30.1TNNI3, PRF1, TNNT2
12membranoproliferative glomerulonephritis30.1CFP, MBL2
13nephritis30.0APOH, CFP, FCGR2A
14heart valve disease30.0APOH, LECT1
15tuberculosis29.9EPX, PRF1, MBL2
16thrombocytopenia29.9FCGR2A, GP1BA, APOH
17septic shock29.9CFP, MBL2, LBP
18systemic lupus erythematosus29.8CFP, APOH, FCGR2A, MBL2
19collagen disease29.8APOH, MBL2
20sepsis29.7MBL2, LBP, GP1BA, FCGR2A
21behcet's disease29.5MBL2, APOH
22cerebrovascular disease29.5GTF3A, GP1BA, APOH
23lupus nephritis29.5MBL2, FCGR2A, APOH
24vascular disease29.4TNNI3, APOH, TNNT2
25rheumatoid arthritis29.3LBP, FCGR2A, APOH, MBL2
26subacute bacterial endocarditis11.2
27aneurysm10.7
28q fever10.6
29marantic endocarditis10.6
30cerebritis10.5
31ventricular septal defect10.5
32loeffler endocarditis10.5
33rheumatic fever10.5
34mitral valve prolapse10.4
35splenic abscess10.4
36mycobacterium fortuitum10.4
37aortitis10.3
38crescentic glomerulonephritis10.3
39hypereosinophilic syndrome10.3
40kawasaki disease10.3
41pericarditis10.3
42stenotrophomonas maltophilia10.3
43meningococcal meningitis10.3MBL2, CFP
44discitis10.3
45rheumatic congestive heart failure10.3MBL2, LECT1
46antiphospholipid syndrome10.3
47gerbode defect10.3
48complement deficiency10.3MBL2, CFP
49arthritis10.3
50tetralogy of fallot10.3

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to endocarditis

Symptoms for Endocarditis

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Drugs & Therapeutics for Endocarditis

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Drug clinical trials:

Search ClinicalTrials for Endocarditis

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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MalaCards organs/tissues related to Endocarditis:

32
Heart, Skin, Lung, Testes, Colon, Brain, Kidney, Spleen, Liver, Neutrophil, Thyroid, T cells, Endothelial, Prostate, Monocytes, Bone, Breast, Myeloid, B lymphoblasts

Animal Models for Endocarditis or affiliated genes

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MGI Mouse Phenotypes related to Endocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.4CFP, LECT1, FCGR2A, EPX, PRF1, MBL2
2MP:00053977.0LBP, GP1BA, LECT1, FCGR2A, EPX, PRF1
3MP:00053766.7MBL2, LBP, CFP, GP1BA, LECT1, TNNT2

Publications for Endocarditis

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Articles related to Endocarditis:

(show top 50)    (show all 1789)
idTitleAuthorsYear
1
Characteristics and natural history of patients with colorectal cancer complicated by infectious endocarditis. Case control study of 25 patients. (24403486)
2014
2
Surgical treatment for aortic periannular abscess/pseudoaneurysm caused by infective endocarditis. (23161575)
2013
3
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
4
The risk for bacterial endocarditis in cirrhotic patients: a population-based 3-year follow-up study. (23352807)
2013
5
Use of autologous pericardium for mitral leaflet reconstruction in a child with endocarditis. (23939329)
2013
6
CT angiography and A^a8,F-FDG-PET fusion imaging for prosthetic heart valve endocarditis. (24029372)
2013
7
Echocardiographic measurement of cardiac valvular thickness in healthy cows, cows with bacterial endocarditis, and cows with cardiorespiratory diseases. (24252809)
2013
8
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. (24341951)
2013
9
Left kidney infarction in a patient with native aortic valve infective endocarditis: diagnosis with contrast-enhanced ultrasound. (24432168)
2013
10
Comparison between early and late prosthetic valve endocarditis: clinical characteristics and outcomes. (24224422)
2013
11
Hairy cell leukemia masquerading as infective endocarditis. (24426343)
2013
12
Impact of haplotypes of TNF in the natural course of infective endocarditis. (24165416)
2013
13
Triple cusps replacement for active aortic endocarditis. (23557585)
2013
14
Infective endocarditis giving rise to peritonitis in a patient on peritoneal dialysis. (23843595)
2013
15
OPAT outcomes in endocarditis. (23615590)
2013
16
Splinter haemorrhages, Osler's nodes, Janeway lesions and Roth spots: the peripheral stigmata of endocarditis. (24273777)
2013
17
Cardiac device infective endocarditis and patient survival. (22910745)
2012
18
Staphylococcus aureus mitral valve endocarditis due to heel decubitus ulcer. (22669924)
2012
19
Clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. (23983869)
2012
20
Rapidly progressive glomerulonephritis associated with PR3-ANCA positive subacute bacterial endocarditis. (22989831)
2012
21
Timing for surgery in patients with infective endocarditis and cerebrovascular complications--waiting may be best but results of early surgery are acceptable and improvements in neurology are common. (22219446)
2012
22
Dentigenous infectious foci - a risk factor of infective endocarditis. (22293883)
2012
23
Endocarditis and myocarditis: a brief review. (23098151)
2012
24
Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels. (22302637)
2012
25
Recurrent Infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (e coli) after therapeutic ERCP. (22720314)
2012
26
Infective endocarditis and spondylodiscitis due to posterior nasal packing in a patient with a bioprosthetic aortic valve. (22447509)
2012
27
Coxiella burnetii endocarditis after Q fever vaccination. (22956746)
2012
28
Mycotic Celiac Artery Aneurysm Following Infective Endocarditis: Successful Treatment Using N-butyl Cyanoacrylate with Embolization Coils. (23555513)
2012
29
An atypical presentation of infective endocarditis. (23182295)
2012
30
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. (21963210)
2011
31
Successful combination therapy with vancomycin and arbekacin against infective endocarditis caused by MRSA. (22686009)
2011
32
Infective endocarditis in mitral mechanical prosthesis: the role of three-dimensional transoesophageal echocardiography. (21795251)
2011
33
Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. (18797945)
2009
34
Dual ANCA positivity in subacute bacterial endocarditis. (18431098)
2008
35
Gerbode type defect and third degree atrioventricular block in association with bacterial endocarditis in a dog. (19010115)
2008
36
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
37
Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. (16188499)
2005
38
Rapid reversion of Loeffler's endocarditis by imatinib in early stage clonal hypereosinophilic syndrome. (15621768)
2004
39
The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)
2000
40
Disseminated Mycobacterium chelonae infection resulting in endocarditis. (8953086)
1996
41
Demonstration of microorganisms in subacute bacterial endocarditis. (7610438)
1995
42
Acquired bisalbuminemia in staphylococcal endocarditis treated with dicloxacillin. (1287818)
1992
43
Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. (1778210)
1991
44
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. (1985118)
1991
45
SUBACUTE BACTERIAL ENDOCARDITIS PRESENTING WITH HAEMOPERITONEUM FROM RUPTURED MYCOTIC ANEURYSM. (14252919)
1964
46
Subacute bacterial endocarditis. Clinical and laboratory observations in 27 consecutive cases treated with penicillin V by mouth. (13738726)
1961
47
Phagocytic reticuloendothelial cells in subacute bacterial endocarditis with negative cultures. (13852405)
1960
48
Subacute bacterial endocarditis; clinical and therapeutic considerations. (14382895)
1955
49
Bacteriostatic agents in the treatment of subacute bacterial endocarditis. (13126547)
1954
50
Experiences in the management of subacute bacterial endocarditis treated with penicillin. (18920942)
1948

Variations for Endocarditis

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Expression for genes affiliated with Endocarditis

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Expression patterns in normal tissues for genes affiliated with Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for genes affiliated with Endocarditis

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Pathways related to Endocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TNNI3, TNNT2
2
Show member pathways
9.7TNNI3, TNNT2
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6MBL2, CFP
49.4MBL2, FCGR2A

Compounds for genes affiliated with Endocarditis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Endocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1abciximab44 1111.0GP1BA, FCGR2A
2mannan449.9MBL2, CFP
3rrna449.9GTF3A, CS
4methanol44 2410.8APOH, EPX
5ptca449.8TNNT2, APOH
6phosphorus449.8APOH, CFP
7polymyxin b449.8LBP, MBL2
8phosphatidylethanolamine44 1110.8APOH, LBP
9p002449.8CS, EPX, APOH
10phenylalanine449.8CS, FCGR2A, GP1BA
11adenine44 24 1111.7GTF3A, CS, GP1BA
12etanercept44 50 1111.6FCGR2A, APOH
13cytochalasin b449.6EPX, GP1BA
14prostacyclin449.6GP1BA, APOH, FCGR2A
15cardiolipin44 1110.6MBL2, APOH
16infliximab44 50 1111.5FCGR2A, APOH
17ivig449.4APOH, FCGR2A, GTF3A
18agarose449.4MBL2, EPX, APOH
19p003449.4APOH, CS, MBL2
20lipoteichoic acid449.4LBP, APOH, MBL2
21latex449.4MBL2, APOH, GP1BA
22phosphatidylserine44 28 1111.4MBL2, APOH, GP1BA
23aspartate449.3LBP, EPX, CS, MBL2
24histidine449.3GTF3A, CS, PRF1, FCGR2A
25ethanol44 50 24 1112.3APOH, CS, MBL2
26polysaccharide449.2LBP, CFP, FCGR2A, MBL2
27phospholipid449.2LBP, APOH, PRF1
28dexamethasone44 50 28 1112.2MBL2, CS, EPX, LBP
29phosphatidylinositol449.1LBP, GP1BA, APOH, FCGR2A
30mannose449.1CFP, APOH, FCGR2A, MBL2
31prednisolone44 28 1111.1MBL2, EPX, FCGR2A, APOH
32phosphatidylcholine449.0MBL2, PRF1, APOH, LBP
33alanine448.9LBP, GP1BA, TNNT2, CS, GTF3A
34steroid448.9APOH, EPX, MBL2, GTF3A
35nitric oxide44 24 1110.8LBP, APOH, EPX, CS, MBL2
36lactate448.8GP1BA, TNNT2, TNNI3, APOH, EPX, CS
37valine448.7GP1BA, APOH, FCGR2A, CS, MBL2
38fibrinogen448.6LBP, GP1BA, APOH, MBL2, GTF3A
39glucose448.6GP1BA, APOH, CS, MBL2, GTF3A
40atp44 289.5APOH, FCGR2A, CS, MBL2, GTF3A
41oxygen44 249.4LBP, APOH, FCGR2A, EPX, CS, MBL2
42tyrosine448.4LBP, GP1BA, FCGR2A, EPX, MBL2
43heparin44 28 24 1111.3LBP, CFP, GP1BA, TNNT2, APOH, FCGR2A
44cholesterol44 28 24 1111.3LBP, APOH, FCGR2A, PRF1, CS, MBL2
45vegf448.3GTF3A, MBL2, APOH, LECT1
46superoxide44 249.2MBL2, LBP, CFP, APOH, EPX, PRF1
47creatinine448.1LBP, TNNT2, TNNI3, APOH, EPX, CS
48serine447.7LBP, GP1BA, FCGR2A, EPX, PRF1, CS
49lipid447.6LBP, LECT1, APOH, FCGR2A, EPX, CS
50calcium44 50 24 1110.4GP1BA, TNNT2, TNNI3, APOH, FCGR2A, EPX

GO Terms for genes affiliated with Endocarditis

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Cellular components related to Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.6TNNI3, TNNT2
2sarcomereGO:0300179.4TNNI3, TNNT2
3extracellular regionGO:0055768.1MBL2, PRF1, LECT1, CFP, LBP

Biological processes related to Endocarditis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.0TNNI3, TNNT2
2ventricular cardiac muscle tissue morphogenesisGO:0550109.9TNNI3, TNNT2
3blood coagulation, intrinsic pathwayGO:0075979.9GP1BA, APOH
4opsonizationGO:0082289.8MBL2, LBP
5cellular defense responseGO:0069689.8PRF1, LBP
6negative regulation of growth of symbiont in hostGO:0441309.7MBL2, LBP
7muscle filament slidingGO:0300499.7TNNT2, TNNI3
8defense response to Gram-positive bacteriumGO:0508309.6MBL2, LBP
9acute-phase responseGO:0069539.6MBL2, LBP
10complement activationGO:0069569.5MBL2, CFP
11negative regulation of endothelial cell proliferationGO:0019379.3APOH, LECT1
12innate immune responseGO:0450879.0LBP, CFP, FCGR2A, MBL2
13negative regulation of angiogenesisGO:0165258.8APOH, LECT1

Molecular functions related to Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.6MBL2, TNNI3
2troponin C bindingGO:0301729.4TNNI3, TNNT2

Products for genes affiliated with Endocarditis

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  • Antibodies
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Sources for Endocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet