MCID: END033
MIFTS: 56

Endocarditis malady

Cardiovascular diseases category
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Summaries for Endocarditis

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Endocarditis, also called infective endocarditis (ie), is an inflammation of the inner lining of the heart. the most common type, bacterial endocarditis, occurs when germs enter your heart. these germs come through your bloodstream from another part of your body, often your mouth. bacterial endocarditis can damage your heart valves. if untreated, it can be life-threatening. it is rare in healthy hearts. risk factors include having an abnormal or damaged heart valve an artificial heart valve congenital heart defects the signs and symptoms of ie can vary from person to person. they also can vary over time in the same person. symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. your doctor will diagnose ie based on your risk factors, medical history, signs and symptoms, and lab and heart tests. early treatment can help you avoid complications. treatment usually involves high-dose antibiotics. if your heart valve is damaged, you may need surgery. if you're at risk for ie, brush and floss your teeth regularly, and have regular dental checkups. germs from a gum infection can enter your bloodstream. if you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. nih: national heart, lung, and blood institute

MalaCards: Endocarditis is related to infective endocarditis and glomerulonephritis. An important gene associated with Endocarditis is CFP (complement factor properdin), and among its related pathways are Cardiac Progenitor Differentiation and Striated Muscle Contraction. The drug gentamicin sulfate pwdr and the compounds abciximab and mannan have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

Wikipedia:65 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Aliases & Classifications for Endocarditis

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

endocarditis 8 10 45 34 62


External Ids:

Disease Ontology8 DOID:10314
MeSH35 D004696
NCIt40 C34582

Related Diseases for Endocarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 354)
idRelated DiseaseScoreTop Affiliating Genes
1infective endocarditis32.0LECT1
2glomerulonephritis30.8FCGR2A, MBL2, CFP
3bacteremia30.7MBL2, LBP
4meningitis30.6LBP, PRF1, MBL2, CFP, FCGR2A
5myocardial infarction30.5TNNT2, TNNI3, GP1BA, LBP
6congestive heart failure30.4TNNT2, TNNI3
7congenital heart disease30.3TNNT2, CS, TNNI3
8pneumonia30.3LBP, EPX, PRF1, MBL2
9systemic lupus erythematosus30.2CFP, APOH, FCGR2A, MBL2
10hypertrophic cardiomyopathy30.1TNNT2, TNNI3
11myocarditis30.1TNNI3, PRF1, TNNT2
12bacterial meningitis30.0CFP, LBP
13thrombocytopenia30.0FCGR2A, GP1BA, APOH
14tuberculosis29.9EPX, PRF1, MBL2
15nephritis29.9APOH, CFP, FCGR2A
16sepsis29.9MBL2, LBP, GP1BA, FCGR2A
17membranoproliferative glomerulonephritis29.8CFP, MBL2
18rheumatoid arthritis29.8LBP, FCGR2A, APOH, MBL2
19heart valve disease29.7APOH, LECT1
20septic shock29.7CFP, MBL2, LBP
21collagen disease29.7APOH, MBL2
22behcet's disease29.6MBL2, APOH
23cerebrovascular disease29.6GTF3A, GP1BA, APOH
24lupus nephritis29.6MBL2, FCGR2A, APOH
25vascular disease29.6TNNI3, APOH, TNNT2
26subacute bacterial endocarditis11.1
27aneurysm10.7
28q fever10.6
29marantic endocarditis10.6
30cerebritis10.5
31rheumatic fever10.4
32loeffler endocarditis10.4
33ventricular septal defect10.4
34mitral valve prolapse10.4
35splenic abscess10.4
36aortitis10.3
37mycobacterium fortuitum10.3
38crescentic glomerulonephritis10.3
39hypereosinophilic syndrome10.3
40kawasaki disease10.3
41pericarditis10.3
42stenotrophomonas maltophilia10.3
43antiphospholipid syndrome10.3
44discitis10.3
45gerbode defect10.3
46tetralogy of fallot10.2
47patent ductus arteriosus10.2
48arthritis10.2
49leukemia10.2
50pulmonary embolism10.2

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to endocarditis

Symptoms for Endocarditis

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Drugs & Therapeutics for Endocarditis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Endocarditis

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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33MalaCards
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MalaCards organs/tissues related to Endocarditis:

33
Heart, Skin, Lung, Testes, Colon, Brain, Kidney, Spleen, Liver, Endothelial, Thyroid, T cells, Prostate, Myeloid, Monocytes, Bone, Breast

Animal Models for Endocarditis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Endocarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.4CFP, LECT1, FCGR2A, EPX, PRF1, MBL2
2MP:00053977.0LBP, GP1BA, LECT1, FCGR2A, EPX, PRF1
3MP:00053766.7MBL2, LBP, CFP, GP1BA, LECT1, TNNT2

Publications for Endocarditis

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52PubMed
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Articles related to Endocarditis:

(show top 50)    (show all 1746)
idTitleAuthorsYear
1
Characteristics and natural history of patients with colorectal cancer complicated by infectious endocarditis. Case control study of 25 patients. (24403486)
2014
2
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
3
The risk for bacterial endocarditis in cirrhotic patients: a population-based 3-year follow-up study. (23352807)
2013
4
Use of autologous pericardium for mitral leaflet reconstruction in a child with endocarditis. (23939329)
2013
5
CT angiography and A^a8,F-FDG-PET fusion imaging for prosthetic heart valve endocarditis. (24029372)
2013
6
Echocardiographic measurement of cardiac valvular thickness in healthy cows, cows with bacterial endocarditis, and cows with cardiorespiratory diseases. (24252809)
2013
7
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. (24341951)
2013
8
Left kidney infarction in a patient with native aortic valve infective endocarditis: diagnosis with contrast-enhanced ultrasound. (24432168)
2013
9
Comparison between early and late prosthetic valve endocarditis: clinical characteristics and outcomes. (24224422)
2013
10
Hairy cell leukemia masquerading as infective endocarditis. (24426343)
2013
11
Impact of haplotypes of TNF in the natural course of infective endocarditis. (24165416)
2013
12
Triple cusps replacement for active aortic endocarditis. (23557585)
2013
13
Infective endocarditis giving rise to peritonitis in a patient on peritoneal dialysis. (23843595)
2013
14
OPAT outcomes in endocarditis. (23615590)
2013
15
Splinter haemorrhages, Osler's nodes, Janeway lesions and Roth spots: the peripheral stigmata of endocarditis. (24273777)
2013
16
Cardiac device infective endocarditis and patient survival. (22910745)
2012
17
Staphylococcus aureus mitral valve endocarditis due to heel decubitus ulcer. (22669924)
2012
18
Clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. (23983869)
2012
19
Rapidly progressive glomerulonephritis associated with PR3-ANCA positive subacute bacterial endocarditis. (22989831)
2012
20
Timing for surgery in patients with infective endocarditis and cerebrovascular complications--waiting may be best but results of early surgery are acceptable and improvements in neurology are common. (22219446)
2012
21
Dentigenous infectious foci - a risk factor of infective endocarditis. (22293883)
2012
22
Endocarditis and myocarditis: a brief review. (23098151)
2012
23
Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels. (22302637)
2012
24
Recurrent Infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (e coli) after therapeutic ERCP. (22720314)
2012
25
Infective endocarditis and spondylodiscitis due to posterior nasal packing in a patient with a bioprosthetic aortic valve. (22447509)
2012
26
Coxiella burnetii endocarditis after Q fever vaccination. (22956746)
2012
27
Mycotic Celiac Artery Aneurysm Following Infective Endocarditis: Successful Treatment Using N-butyl Cyanoacrylate with Embolization Coils. (23555513)
2012
28
An atypical presentation of infective endocarditis. (23182295)
2012
29
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. (21963210)
2011
30
Successful combination therapy with vancomycin and arbekacin against infective endocarditis caused by MRSA. (22686009)
2011
31
Infective endocarditis in mitral mechanical prosthesis: the role of three-dimensional transoesophageal echocardiography. (21795251)
2011
32
Antiphospholipid syndrome and homozygous factor V Leiden mutation in a young patient with Libman-Sacks endocarditis and stroke. (20800139)
2010
33
Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. (18797945)
2009
34
Dual ANCA positivity in subacute bacterial endocarditis. (18431098)
2008
35
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
36
Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. (16188499)
2005
37
Rapid reversion of Loeffler's endocarditis by imatinib in early stage clonal hypereosinophilic syndrome. (15621768)
2004
38
The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)
2000
39
Disseminated Mycobacterium chelonae infection resulting in endocarditis. (8953086)
1996
40
Demonstration of microorganisms in subacute bacterial endocarditis. (7610438)
1995
41
Acquired bisalbuminemia in staphylococcal endocarditis treated with dicloxacillin. (1287818)
1992
42
Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. (1778210)
1991
43
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. (1985118)
1991
44
SUBACUTE BACTERIAL ENDOCARDITIS PRESENTING WITH HAEMOPERITONEUM FROM RUPTURED MYCOTIC ANEURYSM. (14252919)
1964
45
Subacute bacterial endocarditis. Clinical and laboratory observations in 27 consecutive cases treated with penicillin V by mouth. (13738726)
1961
46
Phagocytic reticuloendothelial cells in subacute bacterial endocarditis with negative cultures. (13852405)
1960
47
Subacute bacterial endocarditis; clinical and therapeutic considerations. (14382895)
1955
48
Bacteriostatic agents in the treatment of subacute bacterial endocarditis. (13126547)
1954
49
Experiences in the management of subacute bacterial endocarditis treated with penicillin. (18920942)
1948
50
On congestive heart failure after clinically healed subacute bacterial endocarditis. (18864134)
1948

Variations for Endocarditis

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Expression for genes affiliated with Endocarditis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for genes affiliated with Endocarditis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 60Thomson Reuters, 57SinoBiological, 30KEGG
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Pathways related to Endocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TNNI3, TNNT2
2
Show member pathways
9.7TNNI3, TNNT2
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6MBL2, CFP
49.4MBL2, FCGR2A

Compounds for genes affiliated with Endocarditis

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Endocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1abciximab45 1111.0GP1BA, FCGR2A
2mannan459.9MBL2, CFP
3rrna459.9GTF3A, CS
4methanol45 2410.8APOH, EPX
5ptca459.8TNNT2, APOH
6phosphorus459.8APOH, CFP
7polymyxin b459.8LBP, MBL2
8phosphatidylethanolamine45 1110.8APOH, LBP
9p002459.8CS, EPX, APOH
10phenylalanine459.8CS, FCGR2A, GP1BA
11adenine45 24 1111.7GTF3A, CS, GP1BA
12etanercept45 51 1111.6FCGR2A, APOH
13cytochalasin b459.6EPX, GP1BA
14prostacyclin459.6GP1BA, APOH, FCGR2A
15cardiolipin45 1110.6MBL2, APOH
16infliximab45 51 1111.5FCGR2A, APOH
17ivig459.4APOH, FCGR2A, GTF3A
18agarose459.4MBL2, EPX, APOH
19p003459.4APOH, CS, MBL2
20lipoteichoic acid459.4LBP, APOH, MBL2
21latex459.4MBL2, APOH, GP1BA
22phosphatidylserine45 29 1111.4MBL2, APOH, GP1BA
23aspartate459.3LBP, EPX, CS, MBL2
24histidine459.3GTF3A, CS, PRF1, FCGR2A
25ethanol45 51 24 1112.3APOH, CS, MBL2
26polysaccharide459.2LBP, CFP, FCGR2A, MBL2
27phospholipid459.2LBP, APOH, PRF1
28dexamethasone45 51 29 1112.2MBL2, CS, EPX, LBP
29phosphatidylinositol459.1LBP, GP1BA, APOH, FCGR2A
30mannose459.1CFP, APOH, FCGR2A, MBL2
31prednisolone45 29 1111.1MBL2, EPX, FCGR2A, APOH
32phosphatidylcholine459.0MBL2, PRF1, APOH, LBP
33alanine458.9LBP, GP1BA, TNNT2, CS, GTF3A
34steroid458.9APOH, EPX, MBL2, GTF3A
35nitric oxide45 24 1110.8LBP, APOH, EPX, CS, MBL2
36lactate458.8GP1BA, TNNT2, TNNI3, APOH, EPX, CS
37valine458.7GP1BA, APOH, FCGR2A, CS, MBL2
38fibrinogen458.6LBP, GP1BA, APOH, MBL2, GTF3A
39glucose458.6GP1BA, APOH, CS, MBL2, GTF3A
40atp45 299.5APOH, FCGR2A, CS, MBL2, GTF3A
41oxygen45 249.4LBP, APOH, FCGR2A, EPX, CS, MBL2
42tyrosine458.4LBP, GP1BA, FCGR2A, EPX, MBL2
43heparin45 29 24 1111.3LBP, CFP, GP1BA, TNNT2, APOH, FCGR2A
44cholesterol45 29 24 1111.3LBP, APOH, FCGR2A, PRF1, CS, MBL2
45vegf458.3GTF3A, MBL2, APOH, LECT1
46superoxide45 249.2MBL2, LBP, CFP, APOH, EPX, PRF1
47creatinine458.1LBP, TNNT2, TNNI3, APOH, EPX, CS
48serine457.7LBP, GP1BA, FCGR2A, EPX, PRF1, CS
49lipid457.6LBP, LECT1, APOH, FCGR2A, EPX, CS
50calcium45 51 24 1110.4GP1BA, TNNT2, TNNI3, APOH, FCGR2A, EPX

GO Terms for genes affiliated with Endocarditis

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16Gene Ontology
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Cellular components related to Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.6TNNI3, TNNT2
2sarcomereGO:0300179.4TNNI3, TNNT2
3extracellular regionGO:0055768.1MBL2, PRF1, LECT1, CFP, LBP

Biological processes related to Endocarditis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.0TNNI3, TNNT2
2ventricular cardiac muscle tissue morphogenesisGO:0550109.9TNNI3, TNNT2
3blood coagulation, intrinsic pathwayGO:0075979.9GP1BA, APOH
4opsonizationGO:0082289.8MBL2, LBP
5cellular defense responseGO:0069689.8PRF1, LBP
6negative regulation of growth of symbiont in hostGO:0441309.7MBL2, LBP
7muscle filament slidingGO:0300499.7TNNT2, TNNI3
8defense response to Gram-positive bacteriumGO:0508309.6MBL2, LBP
9acute-phase responseGO:0069539.6MBL2, LBP
10complement activationGO:0069569.5MBL2, CFP
11negative regulation of endothelial cell proliferationGO:0019379.3APOH, LECT1
12innate immune responseGO:0450879.0LBP, CFP, FCGR2A, MBL2
13negative regulation of angiogenesisGO:0165258.8APOH, LECT1

Molecular functions related to Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.6MBL2, TNNI3
2troponin C bindingGO:0301729.4TNNI3, TNNT2

Products for genes affiliated with Endocarditis

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Sources for Endocarditis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet