MCID: END016
MIFTS: 44

Endocervicitis malady

Summaries for Endocervicitis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Endocervicitis, also known as endocervicitis unspecified, is related to adenocarcinoma and adenocarcinoma in situ. An important gene associated with Endocervicitis is MYC (v-myc avian myelocytomatosis viral oncogene homolog). The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and ovary, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Endocervicitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
See all sources

Aliases & Descriptions:

endocervicitis 8 10 60
endocervicitis unspecified 8


External Ids:

Disease Ontology8 DOID:5757
NCIt39 C26762

Related Diseases for Endocervicitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Endocervicitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2CDKN2A, CDX2, KRT5, KRT7, KRT20, MSLN
2adenocarcinoma in situ30.9CDKN2A
3cervical adenocarcinoma30.5CEACAM5, CALB2, MUC5AC, CDKN2A, CDX2, KRT7
4endometriosis30.3CALB2
5papilloma30.0KRT20, KRT5, CDKN2A
6neuroendocrine carcinoma30.0NKX2-1, CDX2, KRT7, KRT20, CEACAM5
7gastric adenocarcinoma30.0MYC, CDX2, KRT7, KRT20, CEACAM7, CEACAM5
8endometrial carcinoma30.0CALB2, CDKN2A, CDX2, KRT7, KRT20, CEACAM5
9adenoma30.0CEACAM7, CEACAM5, PAX2, KRT20, KRT7, CALB2
10intestinal neoplasm29.8TFF2, KRT20
11cervical squamous cell carcinoma29.8CDKN2A, CEACAM5
12sarcoma29.8CALB2
13cervical cancer29.8MYC, CDKN2A, KRT5, CEACAM7
14papillary carcinoma29.8CALB2, NKX2-1, KRT7, KRT20
15ovarian cancer29.8KLK7, CALB2, MYC, CDKN2A, KRT5, KRT7
16colorectal cancer29.8MYC, MUC6, MUC5AC, CDKN2A, CDX2, KRT5
17squamous cell carcinoma29.8CALB2, NKX2-1, MYC, MUC6, MUC5AC, CDKN2A
18endometrial adenocarcinoma10.6
19cervicitis10.6
20endocervical carcinoma10.5
21mucinous adenocarcinoma10.3
22vaginitis10.2
23endometritis10.2
24peritonitis10.2
25endocervical type cervical adenomyoma10.1
26endocervical type cervical mucinous adenocarcinoma10.1
27infertility10.1
28peutz-jeghers syndrome10.1
29salpingitis10.1
30ovarian endometriosis10.0
31neurofibrosarcoma10.0
32ovarian mucinous adenocarcinoma10.0
33gonorrhea10.0
34endometrial mucinous adenocarcinoma10.0
35lobular neoplasia10.0
36malignant peripheral nerve sheath tumor10.0
37ovary adenocarcinoma10.0
38cystadenoma10.0KRT7
39esophagitis10.0CDX2
40adenomatoid tumor10.0CALB2
41meningioma10.0CALB2
42stomach cancer10.0CDX2
43inverted papilloma10.0KRT20
44secretory meningioma10.0KRT7
45teratoma10.0KRT7, NKX2-1
46cystadenocarcinoma10.0MUC5AC, CEACAM5
47angiosarcoma10.0CALB2
48herpes simplex10.0CDX2
49bladder carcinoma10.0CDKN2A, KRT20
50malignant pleural mesothelioma10.0MSLN, CALB2

Graphical network of the top 20 diseases related to Endocervicitis:



Diseases related to endocervicitis

Clinical Features for Endocervicitis

About this section

Drugs & Therapeutics for Endocervicitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Endocervicitis

Drug clinical trials:

Search ClinicalTrials for Endocervicitis

Search NIH Clinical Center for Endocervicitis

Search CenterWatch for Endocervicitis

Genetic Tests for Endocervicitis

About this section

Anatomical Context for Endocervicitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Endocervicitis:

32
Cervix, Testes, Ovary, Uterus, Thyroid, T cells, Smooth muscle

Animal Models for Endocervicitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Endocervicitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2PAX2, CDX2, CDKN2A, MYC, TFF2, PDX1
2MP:00053819.8KRT5, PDX1, TFF2, NKX2-1, MYC, MUC5AC

Publications for Endocervicitis

About this section
Sources:
50PubMed
See all sources

Articles related to Endocervicitis:

(show top 50)    (show all 175)
idTitleAuthorsYear
1
A Case of HPV-negative Intestinal-type Endocervical Adenocarcinoma In Situ With Coexisting Multifocal Intestinal and Gastric Metaplasia. (24418863)
2014
2
Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia after large loop excision of transformation zone: do we need a different follow-up strategy? (22765238)
2013
3
Endocervical glandular involvement, multicentricity, and extent of the disease are features of high-grade cervical intraepithelial neoplasia. (23665088)
2013
4
Intestinal-type endocervical adenocarcinoma in situ: an immunophenotypically distinct subset of AIS affecting older women. (23552379)
2013
5
MR imaging findings of extraovarian endocervical mucinous borderline tumors arising from pelvic endometriosis. (24265567)
2013
6
Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A. (22653341)
2012
7
The value of endocervical curettage after conization for cervical intraepithelial neoplasia. (22115536)
2012
8
Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model. (23053434)
2012
9
In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa. (21984929)
2011
10
Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma. (21701666)
2011
11
Five commonly used markers (p53, TTF1, CK7, CK20, and CK34betaE12) are of no use in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray extension study. (19444461)
2010
12
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. (20819643)
2010
13
Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival. (19952931)
2010
14
Comparing the scoring mechanisms of p16INK4a immunohistochemistry based on independent nucleic stains and independent cytoplasmic stains in distinguishing between endocervical and endometrial adenocarcinomas in a tissue microarray study. (19418062)
2010
15
True cytokeratin 8/18 immunohistochemistry is of no use in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray study. (20407331)
2010
16
Endocervical-like (MA1llerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation. (20955384)
2010
17
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. (20061933)
2010
18
Large endocervical polyp with cartilaginous and osseous metaplasia: a hitherto unreported entity. (19047901)
2009
19
Endocervical adenocarcinoma in situ, serous type. (19188821)
2009
20
Effect of sulfasalazine on basal and bacteria-stimulated interleukin-8 production by endocervical epithelial cells. (19239421)
2009
21
Distribution pattern and marker profile show two subpopulations of reserve cells in the endocervical canal. (19483623)
2009
22
Distinguishing mucinous adenocarcinoma of the endometrium from benign endocervical epithelium. (19696620)
2009
23
Endocervical adenocarcinoma associated with lobular endocervical glandular hyperplasia showing rapid reaccumulation of hydrometra. (18217972)
2008
24
Cervical intraepithelial neoplasia III arising in an endocervical polyp. (19065383)
2008
25
Immunohistochemical differences between mucinous and microglandular adenocarcinomas of the endometrium and benign endocervical epithelium. (18753965)
2008
26
Prevalence of goblet cell metaplasia in endocervical and endometrial adenocarcinoma : a histochemical study. (22593653)
2007
27
Ovarian endometriosis associated with ovarian cancer and endometrial-endocervical polyps. (17578358)
2007
28
Lobular endocervical glandular hyperplasia as a presumed precursor of cervical adenocarcinoma independent of human papillomavirus infection. (17540439)
2007
29
Differential expression of cyclin-dependent kinase inhibitors and apoptosis-related proteins in endocervical lesions. (17693084)
2007
30
Dysplastic endocervical curettings: a predictor of cervical squamous cell carcinoma. (17466706)
2007
31
Spectrum of molecular alterations in colorectal, upper urinary tract, endocervical, and renal carcinomas arising in a patient with hereditary non-polyposis colorectal cancer. (16639607)
2006
32
Ovarian atypical proliferative (borderline) mucinous tumors: gastrointestinal and seromucinous (endocervical-like) types are immunophenotypically distinctive. (16306790)
2006
33
Expression of Ki-67 and squamous intraepithelial lesions are related with HPV in endocervical adenocarcinoma. (15999157)
2005
34
Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AIS. (16327433)
2005
35
Re: Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papilloma virus (HPV) DNA detection. (15223971)
2004
36
Apoptosis, proliferation, and expression of p53 and bcl-2 in endocervical glandular intraepithelial lesions and invasive endocervical adenocarcinoma. (14668542)
2004
37
An investigation of the mechanisms underlying the disparity between rate of residual endocervical adenocarcinoma in situ (AIS) in hysterectomy specimens and clinical failure rate following conservatively treated AIS. (15487451)
2004
38
Putative gene loci associated with carcinogenesis and metastasis of endocervical adenocarcinomas of uterus determined by conventional and array-based CGH. (15507938)
2004
39
Symposium part 4: Should pathologists diagnose endocervical preneoplastic lesions "less than" adenocarcinoma in situ?: Counterpoint. (12496693)
2003
40
Ovarian mucinous and mixed epithelial carcinomas of mullerian (endocervical-like) type: a clinicopathologic analysis of four cases of an uncommon variant associated with endometriosis. (12496697)
2003
41
A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. (11781517)
2002
42
Endocervical adenocarcinoma in situ of tubal type and its relation to atypical tubal metaplasia. (9891235)
1999
43
The status and distance of cone biopsy margins as a predictor of excision adequacy for endocervical adenocarcinoma in situ. (9620030)
1998
44
Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. (9314589)
1997
45
Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells. (9257188)
1997
46
Bulky endocervical carcinoma: a 23-year experience. (1612949)
1992
47
The use and limitations of endocervical Gram stains and mucopurulent cervicitis as predictors for Chlamydia trachomatis in female adolescents. (2440306)
1987
48
New treatment of endocervicitis]. (5631984)
1967
49
Management of chronic endocervicitis in infertility. (18113709)
1949
50
ELECTROTHERMOCAUTERY TREATMENT OF LEUKORRHEA DUE TO ENDOCERVICITIS. (18739169)
1923

Genetic Variations for Endocervicitis

About this section

Expression for genes affiliated with Endocervicitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endocervicitis

Search GEO for disease gene expression data for Endocervicitis.

Pathways for genes affiliated with Endocervicitis

About this section

Compounds for genes affiliated with Endocervicitis

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Endocervicitis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CEACAM7, CALB2
2butyrate4410.7CEACAM7, CDX2, CALB2
3tachyplesin i4410.6CDKN2A, MYC
45fluorouracil4410.5MUC6, MUC5AC, CDKN2A, CEACAM7, CEACAM5
55-aza-2deoxycytidine4410.5MYC, CDKN2A, CDX2, KRT7
6hyaluronic acid44 2411.5CALB2, MYC, KRT20, MSLN, CEACAM5
7mucicarmine4410.5CALB2, NKX2-1, KRT7, KRT20, CEACAM7, CEACAM5
8ribonucleic acid4410.5NKX2-1, MYC, MUC5AC, KRT20, CEACAM5
9thymidine44 2411.5CALB2, PDX1, MYC, CDX2, CEACAM7, CEACAM5
10neomycin4410.5PDX1, CDKN2A, CEACAM5
11threonine4410.4PDX1, NKX2-1, MYC, MUC5AC, CDKN2A, KRT5
12retinoid4410.4KRT7, KRT5, MUC5AC, MYC
13oligonucleotide4410.4PDX1, NKX2-1, MYC, MUC6, MUC5AC, CDKN2A
14b 7234410.4CEACAM5, CEACAM7, MSLN, KRT20, KRT7, NKX2-1
15hematoxylin4410.4CALB2, NKX2-1, MUC5AC, CDKN2A, KRT7, KRT20
16vegf4410.4PDX1, MYC, CDKN2A, KRT7, KRT20, MSLN
17n acetylcysteine4410.4CDKN2A, MUC5AC, MYC, PDX1
18testosterone44 59 11 2413.4CALB2, MUC5AC, CDKN2A, KRT5, KRT7, KRT20
19retinoic acid44 2411.4KLK7, PDX1, NKX2-1, MYC, MUC5AC, CDKN2A
20steroid4410.4CALB2, NKX2-1, MUC5AC, CDKN2A, CDX2, CEACAM5
21silver4410.4CALB2, CDKN2A, CEACAM5
22serine4410.3KLK7, PDX1, NKX2-1, MYC, MUC5AC, CDKN2A
23n-acetylglucosamine4410.3CEACAM5, KRT7, MUC5AC
24paraffin4410.3CALB2, NKX2-1, MYC, CEACAM5, KRT20, KRT7
25doxorubicin44 49 1112.3CEACAM5, KRT20, CDKN2A, MYC
26tyrosine4410.3CALB2, NKX2-1, MYC, MUC5AC, CDX2, KRT5
27progesterone44 59 28 11 2414.2CALB2, NKX2-1, MUC6, MUC5AC, CDKN2A, CDX2
28calcium44 49 11 2413.2KLK7, CALB2, PDX1, TFF2, MUC6, MUC5AC
29polysaccharide4410.1MUC6, MUC5AC, KRT7, CEACAM5
30cytosine44 2411.0CEACAM5, CDKN2A, PDX1

GO Terms for genes affiliated with Endocervicitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Endocervicitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.3CEACAM5, CEACAM7, MSLN
2Golgi lumenGO:00579610.2MUC5AC, MUC6, DEFA5
3intermediate filamentGO:00588210.0KRT20, KRT7, KRT5

Biological processes related to Endocervicitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stem cell differentiationGO:04886310.4PAX2, PDX1
2negative regulation of transcription from RNA polymerase II promoterGO:00012210.0PAX2, CDX2, MYC, NKX2-1, PDX1

Products for genes affiliated with Endocervicitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endocervicitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet