MCID: END016
MIFTS: 44

Endocervicitis malady

Summaries for Endocervicitis

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MalaCards: Endocervicitis, also known as endocervicitis unspecified, is related to adenocarcinoma and adenocarcinoma in situ. An important gene associated with Endocervicitis is MYC (v-myc avian myelocytomatosis viral oncogene homolog). The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and ovary, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Endocervicitis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

endocervicitis 8 10 60
endocervicitis unspecified 8


External Ids:

Disease Ontology8 DOID:5757
NCIt39 C26762

Related Diseases for Endocervicitis

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17GeneCards, 18GeneDecks
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Diseases related to Endocervicitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2CDKN2A, CDX2, KRT5, KRT7, KRT20, MSLN
2adenocarcinoma in situ30.9CDKN2A
3cervical adenocarcinoma30.5CEACAM5, CALB2, MUC5AC, CDKN2A, CDX2, KRT7
4endometriosis30.3CALB2
5papilloma30.0KRT20, KRT5, CDKN2A
6neuroendocrine carcinoma30.0NKX2-1, CDX2, KRT7, KRT20, CEACAM5
7gastric adenocarcinoma30.0MYC, CDX2, KRT7, KRT20, CEACAM7, CEACAM5
8endometrial carcinoma30.0CALB2, CDKN2A, CDX2, KRT7, KRT20, CEACAM5
9adenoma30.0CEACAM7, CEACAM5, PAX2, KRT20, KRT7, CALB2
10intestinal neoplasm29.8TFF2, KRT20
11cervical squamous cell carcinoma29.8CDKN2A, CEACAM5
12sarcoma29.8CALB2
13cervical cancer29.8MYC, CDKN2A, KRT5, CEACAM7
14papillary carcinoma29.8CALB2, NKX2-1, KRT7, KRT20
15ovarian cancer29.8KLK7, CALB2, MYC, CDKN2A, KRT5, KRT7
16colorectal cancer29.8MYC, MUC6, MUC5AC, CDKN2A, CDX2, KRT5
17squamous cell carcinoma29.8CALB2, NKX2-1, MYC, MUC6, MUC5AC, CDKN2A
18endometrial adenocarcinoma10.6
19cervicitis10.6
20endocervical carcinoma10.5
21mucinous adenocarcinoma10.3
22vaginitis10.2
23endometritis10.2
24peritonitis10.2
25endocervical type cervical adenomyoma10.1
26endocervical type cervical mucinous adenocarcinoma10.1
27infertility10.1
28peutz-jeghers syndrome10.1
29salpingitis10.1
30ovarian endometriosis10.0
31neurofibrosarcoma10.0
32ovarian mucinous adenocarcinoma10.0
33gonorrhea10.0
34endometrial mucinous adenocarcinoma10.0
35lobular neoplasia10.0
36malignant peripheral nerve sheath tumor10.0
37ovary adenocarcinoma10.0
38cystadenoma10.0KRT7
39esophagitis10.0CDX2
40adenomatoid tumor10.0CALB2
41meningioma10.0CALB2
42stomach cancer10.0CDX2
43inverted papilloma10.0KRT20
44secretory meningioma10.0KRT7
45teratoma10.0KRT7, NKX2-1
46cystadenocarcinoma10.0MUC5AC, CEACAM5
47angiosarcoma10.0CALB2
48herpes simplex10.0CDX2
49bladder carcinoma10.0CDKN2A, KRT20
50malignant pleural mesothelioma10.0MSLN, CALB2

Graphical network of the top 20 diseases related to Endocervicitis:



Diseases related to endocervicitis

Clinical Features for Endocervicitis

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Drugs & Therapeutics for Endocervicitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Endocervicitis

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Anatomical Context for Endocervicitis

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32MalaCards
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MalaCards organs/tissues related to Endocervicitis:

32
Cervix, Testes, Ovary, Thyroid, Uterus, T cells, Smooth muscle

Animal Models for Endocervicitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endocervicitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2PAX2, CDX2, CDKN2A, MYC, TFF2, PDX1
2MP:00053819.8KRT5, PDX1, TFF2, NKX2-1, MYC, MUC5AC

Publications for Endocervicitis

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50PubMed
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Articles related to Endocervicitis:

(show top 50)    (show all 175)
idTitleAuthorsYear
1
Endocervical involvement in endometrial adenocarcinoma is not prognostically significant and the pathologic assessment of the pattern of involvement is not reproducible. (23063759)
2013
2
PAX8 and PAX2 expression in endocervical adenocarcinoma in situ and high-grade squamous dysplasia. (23202787)
2013
3
Conventional Agar-Based Culture Method, and Nucleic Acid Amplification Test (NAAT) of the cppB Gene for Detection of Neisseria gonorrhea in Pregnant Women Endocervical Swab Specimens. (23983999)
2013
4
Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK11. (23038761)
2012
5
Lobular endocervical glandular hyperplasia in a woman with Peutz-Jeghers syndrome: a case report. (22019584)
2012
6
CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women. (22083068)
2012
7
Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells. (20686813)
2011
8
Combined expression of p161NK4a and p27Kip1, but not p21WAF1, differentiates endocervical from endometrial adenocarcinoma. (22611756)
2011
9
Cyclin D1 immunoreactivity in normal endocervix and diagnostic value in reactive and neoplastic endocervical lesions. (20062011)
2010
10
Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study. (19366452)
2009
11
Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis. (19521097)
2009
12
Progesterone receptor does not improve the performance and test effectiveness of the conventional 3-marker panel, consisting of estrogen receptor, vimentin and carcinoembryonic antigen in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray extension study. (19476621)
2009
13
gp340 promotes transcytosis of human immunodeficiency virus type 1 in genital tract-derived cell lines and primary endocervical tissue. (19553331)
2009
14
Gross features of lobular endocervical glandular hyperplasia in comparison with minimal-deviation adenocarcinoma and stage Ib endocervical-type mucinous adenocarcinoma of the uterine cervix. (18631191)
2008
15
Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas. (18059234)
2007
16
Role of HPV DNA detection and p16(INK4A) protein expression in diagnosis of endocervical adenocarcinoma]. (18346352)
2007
17
Immunoprofile of endocervical and endometrial stromal cells and its potential application in localization of tumor involvement. (17197901)
2007
18
Utility of p16INK4a, CEA, Ki67, P53 and ER/PR in the differential diagnosis of benign, premalignant, and malignant glandular lesions of the uterine cervix and their relationship with Silverberg scoring system for endocervical glandular lesions. (17197900)
2007
19
p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas. (17460447)
2007
20
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. (17718130)
2007
21
Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. (17175478)
2006
22
Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma. (16409624)
2006
23
Immunohistochemical characterization of endocervical papillary serous carcinoma. (16515605)
2006
24
Evaluation of level of expression of p16 (INK4a) in endocervical lesions of uterine cervix]. (16313047)
2005
25
Cytoarchitecture modifications of the human uterine endocervical mucosa in long-term three-dimensional organotypic culture. (16325510)
2005
26
Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells. (15754292)
2005
27
Microbial isolates and antibiogram from endocervical swabs of patients with pelvic inflammatory disease. (14766454)
2004
28
p16 immunoreactivity may assist in the distinction between endometrial and endocervical adenocarcinoma. (12819388)
2003
29
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma. (12877729)
2003
30
Symposium part 3: Should pathologists diagnose endocervical preneoplastic lesions "less than" adenocarcinoma in situ?: Point. (12496692)
2003
31
Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ. (12468353)
2002
32
Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas. (12170086)
2002
33
Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study. (11781516)
2002
34
Metachromasia of the endocervical epithelium in women treated with gonadotropin releasing hormone agonist. (11494062)
2001
35
Superficial endometriosis of the uterine cervix: a report of 20 cases of a process that may be confused with endocervical glandular dysplasia or adenocarcinoma in situ. (12090586)
1999
36
Alterations in the growth factor signal transduction pathways and modulators of the cell cycle in endocervical cells from macaques exposed to TCDD. (9707505)
1998
37
High grade squamous intraepithelial lesion (CIN 3) with extension into the endocervical clefts. Difficulty of cytologic differentiation from adenocarcinoma in situ. (8842162)
1996
38
Cytomegalovirus endocervicitis diagnosed by cervical smear. (1663024)
1991
39
Endocervical carcinoma: a study of 23 patients with clinical-pathological correlation. (6086469)
1984
40
Primary endometrial and endocervical granuloma inguinale (donovanosis). Case report. (6850268)
1983
41
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. (6254556)
1980
42
Clinical response of patients with gonococcal endocervicitis and endometritis-salpingitis-peritonitis to doxycycline. (411373)
1977
43
Cul-de-sac isolates from patients with endometritis-salpingitis-peritonitis and gonococcal endocervicitis. (822716)
1976
44
Endocervical Neisseria meningitidis with meningococcemia. (4997665)
1971
45
Clinical viewpoint on the management of cervicitis and endocervicitis. (13758777)
1961
46
Oral terramycin therapy of chronic endocervicitis in infertile women. (12980154)
1952
47
The present status of endocervicitis. (20281182)
1947
48
Endocervicitis. (18742962)
1934
49
ENDOCERVICITIS-ITS ETIOLOGY, PATHOLOGY, AND TREATMENT. (18741716)
1931
50
A CONSERVATIVE TREATMENT FOR CHRONIC ENDOCERVICITIS. (20316622)
1927

Genetic Variations for Endocervicitis

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Expression for genes affiliated with Endocervicitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endocervicitis

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Pathways for genes affiliated with Endocervicitis

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Compounds for genes affiliated with Endocervicitis

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Endocervicitis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CEACAM7, CALB2
2butyrate4410.7CEACAM7, CDX2, CALB2
3tachyplesin i4410.6CDKN2A, MYC
45fluorouracil4410.5MUC6, MUC5AC, CDKN2A, CEACAM7, CEACAM5
55-aza-2deoxycytidine4410.5MYC, CDKN2A, CDX2, KRT7
6hyaluronic acid44 2411.5CALB2, MYC, KRT20, MSLN, CEACAM5
7mucicarmine4410.5CALB2, NKX2-1, KRT7, KRT20, CEACAM7, CEACAM5
8ribonucleic acid4410.5NKX2-1, MYC, MUC5AC, KRT20, CEACAM5
9thymidine44 2411.5CALB2, PDX1, MYC, CDX2, CEACAM7, CEACAM5
10neomycin4410.5PDX1, CDKN2A, CEACAM5
11threonine4410.4PDX1, NKX2-1, MYC, MUC5AC, CDKN2A, KRT5
12retinoid4410.4KRT7, KRT5, MUC5AC, MYC
13oligonucleotide4410.4PDX1, NKX2-1, MYC, MUC6, MUC5AC, CDKN2A
14b 7234410.4CEACAM5, CEACAM7, MSLN, KRT20, KRT7, NKX2-1
15hematoxylin4410.4CALB2, NKX2-1, MUC5AC, CDKN2A, KRT7, KRT20
16vegf4410.4PDX1, MYC, CDKN2A, KRT7, KRT20, MSLN
17n acetylcysteine4410.4CDKN2A, MUC5AC, MYC, PDX1
18testosterone44 59 11 2413.4CALB2, MUC5AC, CDKN2A, KRT5, KRT7, KRT20
19retinoic acid44 2411.4KLK7, PDX1, NKX2-1, MYC, MUC5AC, CDKN2A
20steroid4410.4CALB2, NKX2-1, MUC5AC, CDKN2A, CDX2, CEACAM5
21silver4410.4CALB2, CDKN2A, CEACAM5
22serine4410.3KLK7, PDX1, NKX2-1, MYC, MUC5AC, CDKN2A
23n-acetylglucosamine4410.3CEACAM5, KRT7, MUC5AC
24paraffin4410.3CALB2, NKX2-1, MYC, CEACAM5, KRT20, KRT7
25doxorubicin44 49 1112.3CEACAM5, KRT20, CDKN2A, MYC
26tyrosine4410.3CALB2, NKX2-1, MYC, MUC5AC, CDX2, KRT5
27progesterone44 59 28 11 2414.2CALB2, NKX2-1, MUC6, MUC5AC, CDKN2A, CDX2
28calcium44 49 11 2413.2KLK7, CALB2, PDX1, TFF2, MUC6, MUC5AC
29polysaccharide4410.1MUC6, MUC5AC, KRT7, CEACAM5
30cytosine44 2411.0CEACAM5, CDKN2A, PDX1

GO Terms for genes affiliated with Endocervicitis

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16Gene Ontology
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Cellular components related to Endocervicitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.3CEACAM5, CEACAM7, MSLN
2Golgi lumenGO:00579610.2MUC5AC, MUC6, DEFA5
3intermediate filamentGO:00588210.0KRT20, KRT7, KRT5

Biological processes related to Endocervicitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stem cell differentiationGO:04886310.4PAX2, PDX1
2negative regulation of transcription from RNA polymerase II promoterGO:00012210.0PAX2, CDX2, MYC, NKX2-1, PDX1

Products for genes affiliated with Endocervicitis

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Sources for Endocervicitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet