MCID: END035
MIFTS: 48

Endocrine Gland Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Gland Cancer

MalaCards integrated aliases for Endocrine Gland Cancer:

Name: Endocrine Gland Cancer 12 14
Malignant Neoplasm of Endocrine Gland 12 69
Endocrine Gland Neoplasms 41 69
Endocrine Neoplasm 12 51
Malignant Tumour of Endocrine Gland 12
Neoplasm of the Endocrine System 28
Neoplasm of Endocrine System 12
Carcinoma of Endocrine Gland 69
Neoplasm of Endocrine Gland 12
Malignant Endocrine Tumor 12
Endocrine Cancer 51
Endocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:170
ICD10 32 C75.9
ICD9CM 34 194.9
MeSH 41 D004701
NCIt 46 C3010 C3575

Summaries for Endocrine Gland Cancer

Disease Ontology : 12 An organ system cancer located in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

MalaCards based summary : Endocrine Gland Cancer, also known as malignant neoplasm of endocrine gland, is related to non-functioning pancreatic endocrine tumor and islet cell tumor. An important gene associated with Endocrine Gland Cancer is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Signaling by GPCR and Endometrial cancer. The drugs Gemcitabine and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include endocrine system, pancreas and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Endocrine Gland Cancer

Diseases related to Endocrine Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 non-functioning pancreatic endocrine tumor 34.3 CHGA GAST SYP
2 islet cell tumor 32.7 CALCA CHGA GAST SST VIP
3 insulinoma 32.6 CHGA GCG IAPP SST
4 multiple endocrine neoplasia, type iia 32.3 CALCA RET SDHB
5 multiple endocrine neoplasia 32.3 CALCA CHGA RET SDHB
6 neuroendocrine tumor 32.3 CALCA CHGA GAST SST SYP
7 multiple endocrine neoplasia, type i 32.3 CHGA GAST GNAS RET SDHB SST
8 small cell cancer of the lung 32.1 CALCA CHGA GAST SST SYP VIP
9 thyroid cancer 32.0 CALCA GNAS HRAS KDR KRAS RET
10 pancreatic cancer 31.7 AREG CHGA GAST HRAS KDR KRAS
11 thyroiditis 30.8 CALCA RET TG
12 von hippel-lindau syndrome 30.6 CHGA RET SDHB
13 functioning pancreatic endocrine tumor 12.1
14 bronchial endocrine tumor 11.9
15 pancreatic neuroendocrine tumor 11.6
16 carney complex variant 11.3
17 parathyroid carcinoma 11.0
18 adrenal carcinoma 11.0
19 ureter small cell carcinoma 10.8 CHGA SYP
20 esophageal neuroendocrine tumor 10.8 CHGA SYP
21 adenoma of the pancreas 10.8 CHGA SST SYP
22 urinary bladder small cell neuroendocrine carcinoma 10.8 CHGA SYP
23 autoimmune atrophic gastritis 10.7 CHGA GAST
24 pituitary carcinoma 10.7 CHGA GNAS SST
25 pancreatoblastoma 10.7 CHGA SST SYP
26 carcinoid tumors, intestinal 10.7 CHGA SST SYP
27 pancreatic somatostatinoma 10.7 CALCA SST SYP
28 mucoepidermoid thyroid carcinoma 10.7 CALCA TG
29 glucagonoma 10.7 CHGA SST VIP
30 ectopic cushing syndrome 10.7 RET SST SYP
31 wdha syndrome 10.7 CALCA SST VIP
32 acute thyroiditis 10.7 CALCA CHGA TG
33 ovarian large-cell neuroendocrine carcinoma 10.7 CHGA SYP
34 gastrointestinal neuroendocrine benign tumor 10.7 CHGA GAST SST
35 gastric neuroendocrine neoplasm 10.7 CHGA GAST SST
36 benign struma ovarii 10.7 HRAS RET TG
37 auditory system cancer 10.7 CHGA SYP
38 struma ovarii 10.7 KRAS RET TG
39 pulmonary blastoma 10.7 CHGA KRAS SYP
40 sigmoid neoplasm 10.7 HRAS KRAS
41 malignant glandular tumor of peripheral nerve sheath 10.7 SST SYP
42 gastric neuroendocrine tumor 10.7 CALCA GAST
43 villous adenoma 10.7 GNAS KRAS SST
44 gender identity disorder 10.7 AR CYP19A1 ESR1
45 malignant struma ovarii 10.7 HRAS RET TG
46 hyperinsulinemic hypoglycemia, familial, 2 10.7 CHGA GAST SST
47 primary pigmented nodular adrenocortical disease 10.7 CHGA GNAS SYP
48 breast papillary carcinoma 10.7 CHGA ESR1 RET SYP
49 mccune-albright syndrome 10.7 CYP19A1 GNAS SST
50 leprosy 2 10.7 CALCA VIP

Graphical network of the top 20 diseases related to Endocrine Gland Cancer:



Diseases related to Endocrine Gland Cancer

Symptoms & Phenotypes for Endocrine Gland Cancer

GenomeRNAi Phenotypes related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.97 KRAS HRAS
2 Decreased viability GR00106-A-0 9.97 KRAS
3 Decreased viability GR00221-A-1 9.97 KDR KRAS ESR1 HRAS RET
4 Decreased viability GR00221-A-2 9.97 KDR KRAS ESR1 HRAS RET
5 Decreased viability GR00221-A-3 9.97 KDR HRAS
6 Decreased viability GR00221-A-4 9.97 KDR ESR1 RET
7 Decreased viability GR00231-A 9.97 RET
8 Decreased viability GR00301-A 9.97 KRAS RET
9 Decreased viability GR00381-A-1 9.97 KRAS

MGI Mouse Phenotypes related to Endocrine Gland Cancer:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.44 KDR HRAS GAST GNAS IAPP MLH1
2 endocrine/exocrine gland MP:0005379 10.39 HRAS GAST GNAS MLH1 RET KRAS
3 cardiovascular system MP:0005385 10.35 KDR HRAS GNAS SDHB RET KRAS
4 growth/size/body region MP:0005378 10.35 ESR1 HRAS IAPP GNAS KDR RET
5 behavior/neurological MP:0005386 10.32 GNAS ESR1 HRAS KDR RET KRAS
6 mortality/aging MP:0010768 10.3 GNAS ESR1 HRAS GAST KDR MLH1
7 immune system MP:0005387 10.27 GNAS ESR1 GAST IAPP KDR RET
8 digestive/alimentary MP:0005381 10.26 HRAS GAST MLH1 RET KRAS SST
9 hematopoietic system MP:0005397 10.26 GNAS ESR1 IAPP KDR RET KRAS
10 nervous system MP:0003631 10.14 GNAS ESR1 HRAS KRAS KDR RET
11 integument MP:0010771 10.13 GNAS ESR1 HRAS KDR MLH1 KRAS
12 normal MP:0002873 10.1 KDR HRAS GNAS SDHB RET KRAS
13 neoplasm MP:0002006 10.09 HRAS GAST GNAS SDHB MLH1 RET
14 no phenotypic analysis MP:0003012 10.02 KDR HRAS GNAS RET KRAS SDHB
15 renal/urinary system MP:0005367 9.91 HRAS GNAS RET KRAS SDHB ESR1
16 reproductive system MP:0005389 9.81 ESR1 MLH1 RET KRAS VIP AREG
17 respiratory system MP:0005388 9.56 GNAS ESR1 HRAS KDR MLH1 RET
18 skeleton MP:0005390 9.28 GNAS ESR1 HRAS IAPP KRAS KDR

Drugs & Therapeutics for Endocrine Gland Cancer

Drugs for Endocrine Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2
Pancrelipase Approved, Investigational Phase 3 53608-75-6
3 Antibodies Phase 3
4 Antibodies, Monoclonal Phase 3
5 Anti-Infective Agents Phase 3
6 Antimetabolites Phase 3
7 Antimetabolites, Antineoplastic Phase 3
8 Antiviral Agents Phase 3
9 Gastrointestinal Agents Phase 3
10 Immunoglobulins Phase 3
11 Immunosuppressive Agents Phase 3
12 pancreatin Phase 3
13
Denosumab Approved Phase 2 615258-40-7
14
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
15
Etoposide Approved Phase 2 33419-42-0 36462
16
Mitotane Approved Phase 2 53-19-0 4211
17
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
18
Doxil Approved June 1999 Phase 2,Phase 1 31703
19 Bone Density Conservation Agents Phase 2
20 Calcium, Dietary Phase 2
21 Diphosphonates Phase 2
22 Anti-Bacterial Agents Phase 2,Phase 1
23 Antibiotics, Antitubercular Phase 2,Phase 1
24 Antimitotic Agents Phase 2
25 Antineoplastic Agents, Hormonal Phase 2
26 Antineoplastic Agents, Phytogenic Phase 2
27 Etoposide phosphate Phase 2
28 Krestin Phase 2
29 Topoisomerase Inhibitors Phase 2,Phase 1
30 Liver Extracts Phase 1
31
Epinephrine Approved, Vet_approved 51-43-4 5816
32 Racepinephrine Approved 329-65-7
33 Hormones Not Applicable
34 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas Terminated NCT01231347 Phase 3 AMG 479;Placebo;AMG 479;gemcitabine
2 Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Completed NCT00896454 Phase 2 denosumab
3 Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer Completed NCT00071058 Phase 2 XR9576 (Tariquidar)
4 Prospective Study Assessing Thyroidectomy Using Robot Recruiting NCT02839655 Phase 2
5 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
6 Genetic Evaluation of Families With Endocrine Cancers Completed NCT01794676
7 B-Receptor Signaling in Cardiomyopathy Completed NCT01135849
8 Pilot for The Breast Cancer Endocrine Therapy Adherence (BETA) Trial Completed NCT02256670 Not Applicable
9 Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms Recruiting NCT01005654
10 Feasibility of Activity Monitoring in Patients With Cancer: Physical Activity Monitoring in Cancer Patients (PAMCaP) Recruiting NCT02583815

Search NIH Clinical Center for Endocrine Gland Cancer

Cochrane evidence based reviews: endocrine gland neoplasms

Genetic Tests for Endocrine Gland Cancer

Genetic tests related to Endocrine Gland Cancer:

# Genetic test Affiliating Genes
1 Neoplasm of the Endocrine System 28

Anatomical Context for Endocrine Gland Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Gland Cancer:

18
Endocrine System

MalaCards organs/tissues related to Endocrine Gland Cancer:

38
Pancreas, Liver, Bone

Publications for Endocrine Gland Cancer

Articles related to Endocrine Gland Cancer:

# Title Authors Year
1
Endocrine gland cancer. ( 8001005 )
1995

Variations for Endocrine Gland Cancer

Expression for Endocrine Gland Cancer

Search GEO for disease gene expression data for Endocrine Gland Cancer.

Pathways for Endocrine Gland Cancer

Pathways related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 AR CALCA ESR1 GAST GCG GNAS
2
Show member pathways
12.93 AR HRAS KDR KRAS MLH1 RET
3 12.42 AR ESR1 GNAS HRAS KRAS MLH1
4
Show member pathways
12.29 CALCA GCG GNAS IAPP
5
Show member pathways
12.27 ESR1 HRAS KDR KRAS
6
Show member pathways
12.21 GAST HRAS KDR KRAS
7 12.17 ESR1 HRAS KDR KRAS
8
Show member pathways
12.05 AREG HRAS KDR KRAS
9 11.95 AR CYP19A1 ESR1 KRAS
10 11.72 GNAS HRAS KRAS
11 11.54 HRAS KRAS RET
12 11.52 CALCA GCG GNAS IAPP VIP
13 11.48 GNAS HRAS KRAS
14
Show member pathways
11.48 HRAS KDR KRAS RET
15
Show member pathways
11.32 AR ESR1 GCG
16 11.26 AR CALCA CYP19A1
17 11.2 HRAS KDR KRAS
18 10.86 ESR1 HRAS KRAS
19 10.72 HRAS KRAS
20 10.61 ESR1 HRAS KRAS RET
21 10.36 GAST VIP
22 9.97 CYP19A1 ESR1

GO Terms for Endocrine Gland Cancer

Cellular components related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AREG CALCA CHGA GAST GCG IAPP
2 extracellular region GO:0005576 9.32 CALCA CHGA GAST GCG GNAS IAPP

Biological processes related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 AR AREG HRAS KDR KRAS VIP
2 cell-cell signaling GO:0007267 9.88 AR AREG CALCA IAPP SST
3 epidermal growth factor receptor signaling pathway GO:0007173 9.71 AREG HRAS KRAS
4 positive regulation of cAMP biosynthetic process GO:0030819 9.69 CALCA GCG GNAS
5 positive regulation of MAPK cascade GO:0043410 9.67 AR HRAS IAPP KDR
6 negative regulation of bone resorption GO:0045779 9.57 CALCA IAPP
7 response to isolation stress GO:0035900 9.56 HRAS KRAS
8 prostate gland growth GO:0060736 9.55 AR CYP19A1
9 amylin receptor signaling pathway GO:0097647 9.52 CALCA IAPP
10 regulation of long-term neuronal synaptic plasticity GO:0048169 9.5 HRAS KRAS SYP
11 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.49 AREG ESR1
12 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.46 CALCA GCG GNAS VIP
13 mammary gland alveolus development GO:0060749 9.43 AR AREG ESR1
14 regulation of receptor activity GO:0010469 9.23 AREG CALCA GAST GCG IAPP SST
15 positive regulation of cAMP metabolic process GO:0030816 9.13 CALCA CHGA IAPP
16 signal transduction GO:0007165 10.1 AR ESR1 GAST GCG GNAS HRAS
17 G-protein coupled receptor signaling pathway GO:0007186 10.03 AREG CALCA GAST GCG GNAS IAPP

Molecular functions related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 CALCA GAST GCG IAPP SST TG

Sources for Endocrine Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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