MCID: END038
MIFTS: 36

Endocrine Pancreas Disease

Categories: Endocrine diseases

Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease 12 14
Disorder of Endocrine Pancreas 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1428
ICD10 32 E16
ICD9CM 34 251

Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to bronchus adenoma and bronchial adenomas/carcinoids childhood. An important gene associated with Endocrine Pancreas Disease is INS (Insulin), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include pancreas, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 bronchus adenoma 10.6 POMC SST
2 bronchial adenomas/carcinoids childhood 10.6 POMC SST
3 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.6 LEP POMC
4 scleredema adultorum 10.6 INS POMC
5 secondary adrenal insufficiency 10.6 IGF1 INS
6 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.5 IGF1 INS
7 sheehan syndrome 10.5 IGF1 INS POMC
8 acidophil adenoma 10.5 IGF1 POMC SST
9 pituitary infarct 10.5 IGF1 POMC SST
10 pancreatic islet cell tumors 10.5 INS SST
11 pituitary-dependent cushing's disease 10.5 INS POMC SST
12 thyroid gland disease 10.5 IGF1 INS POMC
13 hyperinsulinemic hypoglycemia, familial, 3 10.5 ABCC8 GCK
14 maturity-onset diabetes of the young, type 2 10.5 GCK INS
15 gonadal disease 10.5 IGF1 INS POMC
16 hyperandrogenism 10.5 IGF1 INS POMC
17 mixed cell adenoma 10.5 IGF1 IRS1
18 endocrine organ benign neoplasm 10.5 IGF1 POMC SST
19 rubeosis iridis 10.5 IGF1 IGF2 INS
20 anovulation 10.5 IGF1 INS LEP
21 meninges hemangiopericytoma 10.5 IGF1 IGF2 INS
22 pituitary tumors 10.5 IGF1 POMC SST
23 islet cell tumor 10.5 IGF2 INS SST
24 hypoglycemic coma 10.4 IGF2 INS
25 organ system benign neoplasm 10.4 IGF1 POMC SST
26 hypopituitarism 10.4 IGF1 INS POMC
27 postural hypotension 10.4 INS SST
28 hormone producing pituitary cancer 10.4 IGF1 SST
29 diabetes mellitus, transient neonatal, 1 10.4 ABCC8 INS KCNJ11
30 adrenal gland hyperfunction 10.4 LEP POMC SST
31 postgastrectomy syndrome 10.4 GIP INS SST
32 pituitary adenoma, prolactin-secreting 10.4 IGF1 POMC SST
33 alstrom syndrome 10.4 INS KCNJ11 LEP
34 hyperprolactinemia 10.4 IGF1 POMC SST
35 fanconi-bickel syndrome 10.4 ABCC8 G6PC INS
36 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.4 INS LEP SLC2A4
37 pituitary adenoma 10.4 IGF1 POMC SST
38 carbohydrate metabolic disorder 10.4 ABCC8 G6PC INS
39 lipodystrophy, familial partial, type 2 10.4 INS LEP
40 type 1 diabetes mellitus 15 10.4 GCG INS
41 acquired generalized lipodystrophy 10.4 ADIPOQ LEP
42 hyperpituitarism 10.4 IGF1 INS POMC SST
43 pituitary gland disease 10.4 IGF1 INS POMC SST
44 hyperthyroidism 10.4 INS LEP SST
45 cell type benign neoplasm 10.4 IGF1 INS POMC SST
46 munchausen by proxy 10.3 ABCC8 GCK KCNJ11
47 cardiomyopathy, dilated, 1o 10.3 ABCC8 KCNJ11
48 type 1 diabetes mellitus 2 10.3 IGF2 INS
49 fetal macrosomia 10.3 IGF1 IGF2 INS LEP
50 obesity-hypoventilation syndrome 10.3 ADIPOQ LEP

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:



Diseases related to Endocrine Pancreas Disease

Symptoms & Phenotypes for Endocrine Pancreas Disease

MGI Mouse Phenotypes related to Endocrine Pancreas Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.33 DPP4 G6PC INS GCK GIP GLP1R
2 homeostasis/metabolism MP:0005376 10.3 IGF2 DPP4 G6PC INS GCK GIP
3 endocrine/exocrine gland MP:0005379 10.25 IGF2 DPP4 GCK INS ABCC8 GLP1R
4 behavior/neurological MP:0005386 10.2 IGF2 G6PC GLP1R ADIPOQ KCNJ11 SLC5A2
5 adipose tissue MP:0005375 10.18 INS GLP1R ADIPOQ IGF1 SLC5A2 LEP
6 liver/biliary system MP:0005370 9.97 IGF2 G6PC GCK INS ADIPOQ SLC2A4
7 muscle MP:0005369 9.86 IGF2 ADIPOQ IGF1 SLC2A4 KCNJ11 LEP
8 no phenotypic analysis MP:0003012 9.7 IGF2 ABCC8 KCNJ11 SLC5A2 SST INS
9 renal/urinary system MP:0005367 9.61 IGF2 G6PC GCK INS ADIPOQ IGF1
10 skeleton MP:0005390 9.32 IGF2 G6PC INS ADIPOQ IGF1 SLC5A2

Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
2 Antioxidants
3 Central Nervous System Depressants
4 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
2 Glucose Tolerance, Meal Timing and MTNR1B Completed NCT03003936
3 MTNR1B SNP*Food Timing Interaction on Glucose Control Recruiting NCT03036592

Search NIH Clinical Center for Endocrine Pancreas Disease

Genetic Tests for Endocrine Pancreas Disease

Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

38
Pancreas

Publications for Endocrine Pancreas Disease

Variations for Endocrine Pancreas Disease

Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 ABCC8 ADIPOQ G6PC GCG GCK GLP1R
2
Show member pathways
13.3 ABCC8 G6PC GCK KCNJ11 SLC2A4 SLC5A2
3
Show member pathways
12.83 G6PC GCK IGF1 INS IRS1 SLC2A4
4
Show member pathways
12.79 G6PC GCK SLC2A4 SLC5A2 SLC5A4
5
Show member pathways
12.71 ABCC8 GCG GCK GIP GLP1R INS
6
Show member pathways
12.7 ADIPOQ INS IRS1 LEP SLC2A4
7 12.5 ADIPOQ GCG INS IRS1 SLC2A4 SLC5A2
8
Show member pathways
12.39 GCK INS IRS1 LEP
9
Show member pathways
12.36 ADIPOQ G6PC IGF1 INS IRS1 LEP
10
Show member pathways
12.35 ABCC8 ADIPOQ GCG GLP1R INS KCNJ11
11
Show member pathways
12.14 INS IRS1 LEP SLC2A4
12
Show member pathways
12.07 ADIPOQ IGF1 INS IRS1
13
Show member pathways
12.06 G6PC IGF1 INS IRS1 SLC2A4
14 12.04 GCG GIP GLP1R POMC
15 11.97 ADIPOQ IGF1 INS IRS1 LEP SLC2A4
16
Show member pathways
11.96 DPP4 GCG GIP IGF1 INS LEP
17
Show member pathways
11.9 G6PC INS IRS1 SLC2A4
18
Show member pathways
11.89 G6PC GCK SLC2A4 SLC5A2 SLC5A4
19 11.86 ADIPOQ IGF1 INS LEP SLC2A4
20 11.84 G6PC GCG GCK
21
Show member pathways
11.6 DPP4 GCG GIP LEP
22 11.51 IGF1 IGF2 INS
23 11.47 INS IRS1 LEP
24 11.44 ABCC8 IRS1 KCNJ11 LEP SLC2A4
25 11.31 IGF1 INS IRS1
26 11.3 ABCC8 G6PC GCK INS KCNJ11
27 11.27 ADIPOQ G6PC IRS1 LEP POMC SLC2A4
28
Show member pathways
11.15 ABCC8 ADIPOQ GCK INS IRS1 KCNJ11
29 11.1 ADIPOQ IRS1 LEP SLC2A4
30 10.85 INS SLC2A4
31
Show member pathways
10.84 IRS1 SLC2A4

GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ADIPOQ DPP4 GCG GIP IGF1 IGF2
2 sarcolemma GO:0042383 9.5 ABCC8 KCNJ11 SLC2A4
3 secretory granule lumen GO:0034774 9.46 GCG GIP INS POMC
4 extracellular space GO:0005615 9.32 ADIPOQ GCG GIP IGF1 IGF2 INS
5 inward rectifying potassium channel GO:0008282 9.26 ABCC8 KCNJ11

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.97 ABCC8 ADIPOQ GIP KCNJ11 SST
2 carbohydrate metabolic process GO:0005975 9.92 GCK IGF2 INS SLC2A4 SLC5A2
3 positive regulation of protein kinase B signaling GO:0051897 9.88 IGF2 INS IRS1 LEP
4 regulation of receptor activity GO:0010469 9.85 ADIPOQ GCG GIP IGF1 IGF2 INS
5 female pregnancy GO:0007565 9.83 ABCC8 GIP LEP
6 response to nutrient GO:0007584 9.82 ADIPOQ LEP SST
7 insulin receptor signaling pathway GO:0008286 9.81 IGF2 INS IRS1
8 positive regulation of MAPK cascade GO:0043410 9.81 IGF1 IGF2 INS LEP
9 glucose metabolic process GO:0006006 9.8 ADIPOQ GCK IGF2 INS KCNJ11 LEP
10 response to insulin GO:0032868 9.79 ABCC8 IRS1 LEP
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.78 IGF1 INS LEP
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 ADIPOQ IGF1 IGF2 INS
13 response to nutrient levels GO:0031667 9.77 ADIPOQ GIP LEP
14 cellular response to insulin stimulus GO:0032869 9.76 ADIPOQ GCK IRS1 SLC2A4
15 negative regulation of insulin secretion GO:0046676 9.72 ABCC8 IRS1 KCNJ11
16 positive regulation of mitotic nuclear division GO:0045840 9.71 IGF1 IGF2 INS
17 positive regulation of glucose import GO:0046326 9.71 ADIPOQ IGF1 INS IRS1
18 glucose transmembrane transport GO:1904659 9.67 SLC2A4 SLC5A2 SLC5A4
19 positive regulation of insulin receptor signaling pathway GO:0046628 9.67 IGF2 INS IRS1 LEP
20 cellular glucose homeostasis GO:0001678 9.66 ABCC8 GCK
21 insulin-like growth factor receptor signaling pathway GO:0048009 9.65 IGF1 IRS1
22 response to acidic pH GO:0010447 9.65 GIP SST
23 positive regulation of glycogen biosynthetic process GO:0045725 9.65 GCK IGF1 IGF2 INS IRS1
24 glucose 6-phosphate metabolic process GO:0051156 9.63 G6PC GCK
25 cellular response to leptin stimulus GO:0044320 9.63 GCK LEP
26 regulation of appetite GO:0032098 9.62 POMC PPY
27 negative regulation of gluconeogenesis GO:0045721 9.61 ADIPOQ GCK INS
28 bone mineralization involved in bone maturation GO:0035630 9.59 IGF1 LEP
29 positive regulation of glycogen (starch) synthase activity GO:2000467 9.57 ADIPOQ IGF2
30 glucose homeostasis GO:0042593 9.56 ADIPOQ G6PC GCK INS IRS1 LEP
31 regulation of insulin secretion GO:0050796 9.23 ABCC8 DPP4 GCG GCK GIP GLP1R
32 G-protein coupled receptor signaling pathway GO:0007186 10.16 GCG GIP GLP1R INS POMC PPY
33 positive regulation of cell proliferation GO:0008284 10.03 DPP4 IGF1 IGF2 INS IRS1 LEP

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.73 ADIPOQ DPP4 GCG LEP POMC PPY
2 insulin receptor binding GO:0005158 9.46 IGF1 IGF2 INS IRS1
3 glucose:sodium symporter activity GO:0005412 9.37 SLC5A2 SLC5A4
4 ATP-activated inward rectifier potassium channel activity GO:0015272 9.32 ABCC8 KCNJ11
5 hormone activity GO:0005179 9.32 ADIPOQ GCG GIP IGF1 IGF2 INS
6 insulin-like growth factor receptor binding GO:0005159 9.26 IGF1 IGF2 INS IRS1

Sources for Endocrine Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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