MCID: END060
MIFTS: 27

Endolymphatic Hydrops malady

Summaries for Endolymphatic Hydrops

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ménière\'s disease /meɪnˈjɛərz/, also called endolymphatic hydrops, is a disorder of the inner ear... more...

MalaCards: Endolymphatic Hydrops is related to meniere's disease and labyrinthitis. An important gene associated with Endolymphatic Hydrops is MIP (major intrinsic protein of lens fiber), and among its related pathways are Vasopressin-like receptors and NO-dependent CFTR activation (normal and CF). The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and renal/urinary system.

Aliases & Classifications for Endolymphatic Hydrops

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10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

endolymphatic hydrops 10 44 60


Related Diseases for Endolymphatic Hydrops

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endolymphatic Hydrops:



Diseases related to endolymphatic hydrops

Clinical Features for Endolymphatic Hydrops

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Drugs & Therapeutics for Endolymphatic Hydrops

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Endolymphatic Hydrops

Search CenterWatch for Endolymphatic Hydrops

Genetic Tests for Endolymphatic Hydrops

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Anatomical Context for Endolymphatic Hydrops

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Animal Models for Endolymphatic Hydrops or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endolymphatic Hydrops:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8SCNN1A, PHEX, CRLF1, AVPR2, AVP, NOS2
2MP:00053677.7AQP7, HSPA4L, SCNN1A, PHEX, AVPR2, AVP
3MP:00053977.7CRLF1, AVPR2, NOS2, ADD3, ADD2, ADD1
4MP:00036317.2PDE8A, PHEX, CRLF1, CLDN9, AVP, NOS2
5MP:00053866.9PDE8A, SCNN1A, PHEX, CRLF1, CLDN9, AVPR2
6MP:00053766.5PHEX, SCNN1A, PDE8A, HSPA4L, AVPR2, AVP

Publications for Endolymphatic Hydrops

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Genetic Variations for Endolymphatic Hydrops

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Expression for genes affiliated with Endolymphatic Hydrops

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endolymphatic Hydrops

Search GEO for disease gene expression data for Endolymphatic Hydrops.

Pathways for genes affiliated with Endolymphatic Hydrops

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53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AVP, AVPR2
2
NO-dependent CFTR activation (normal and CF)
9.8NOS2, SCNN1A
39.8AVPR2, AVP, AQP2
49.8MIP, AQP2, AQP7
5
Hide members
9.0SCNN1A, MIP, AVPR2, AVP, AQP2, AQP7
6
Hide members
8.8AQP2, ADD1, ADD2, AVP, AVPR2, MIP

Compounds for genes affiliated with Endolymphatic Hydrops

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59Tocris Bioscience, 44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp5910.3AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin5910.3AVPR2, AVP
3[arg8]-vasopressin5910.3AVPR2, AVP
4hgcl24410.3AQP2, MIP
5sr 4905959 2811.3AVP, AVPR2
6desmopressin44 59 28 1113.1AVPR2, AVP, AQP2
7hg2+2810.1MIP, AQP2, AQP7
8mercury4410.0AQP2, MIP
9pcmbs4410.0DNAH8, MIP
10chloride449.9MIP, AVPR2, AVP, AQP2
11thiazide449.9ADD1, SCNN1A
12urea44 11 2411.7HSPA4L, MIP, AQP2
13abscisic acid449.7MIP, AVP
14potassium44 11 2411.7AQP2, ADD1, AVPR2, MIP
15ether449.6DNAH8, AVP
16glycerol44 11 2411.6AQP7, AQP2, MIP, DNAH8
17dexamethasone44 49 28 1112.3SCNN1A, MIP, AVP, NOS2, AQP2
18nitric oxide44 11 2411.3AQP2, ADD1, NOS2, AVP, MIP
19arginine449.0DNAH8, MIP, AVPR2, AVP, NOS2, AQP2
20glutamate449.0DNAH8, MIP, AVPR2, AVP, NOS2
21sodium44 249.5AQP2, ADD1, ADD2, AVP, AVPR2, MIP
22calcium44 49 11 2410.6PHEX, DNAH8, MIP, CLDN9, AVPR2, AVP

GO Terms for genes affiliated with Endolymphatic Hydrops

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16Gene Ontology
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Cellular components related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1F-actin capping protein complexGO:0082909.7ADD1, ADD2
2plasma membraneGO:0058866.6AQP7, SCNN1A, PHEX, CRLF1, MIP, CLDN9

Biological processes related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP7, AQP2
2positive regulation of systemic arterial blood pressureGO:00308410.0AVPR2, AVP
3cell volume homeostasisGO:0068849.7AQP2, ADD1
4actin filament bundle assemblyGO:0510179.7ADD1, ADD2
5excretionGO:0075889.6SCNN1A, AVPR2, AQP2, AQP7
6barbed-end actin filament cappingGO:0510169.6ADD1, ADD2
7water transportGO:0068339.5AQP7, AQP2, AVP, AVPR2, MIP
8transmembrane transportGO:0550859.1SCNN1A, MIP, AVPR2, AVP, AQP2, AQP7

Molecular functions related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water channel activityGO:0152509.7AQP7, MIP
2spectrin bindingGO:0305079.7ADD1, ADD2
3calmodulin bindingGO:0055168.5ADD1, ADD2, ADD3, NOS2, MIP
4actin bindingGO:0037798.4SCNN1A, ADD3, ADD2, ADD1, AQP2

Products for genes affiliated with Endolymphatic Hydrops

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endolymphatic Hydrops

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet