MCID: END060
MIFTS: 40

Endolymphatic Hydrops malady

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Summaries for Endolymphatic Hydrops

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65Wikipedia, 33MalaCards
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MalaCards: Endolymphatic Hydrops is related to meniere's disease and labyrinthitis. An important gene associated with Endolymphatic Hydrops is MIP (major intrinsic protein of lens fiber), and among its related pathways are Vasopressin-regulated water reabsorption and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related mouse phenotypes are nervous system and growth/size/body.

Aliases & Classifications for Endolymphatic Hydrops

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10DISEASES, 45Novoseek, 62UMLS
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Aliases & Descriptions:

endolymphatic hydrops 10 45 62


Related Diseases for Endolymphatic Hydrops

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endolymphatic Hydrops:



Diseases related to endolymphatic hydrops

Symptoms for Endolymphatic Hydrops

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Drugs & Therapeutics for Endolymphatic Hydrops

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Endolymphatic Hydrops

Genetic Tests for Endolymphatic Hydrops

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Anatomical Context for Endolymphatic Hydrops

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33MalaCards
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MalaCards organs/tissues related to Endolymphatic Hydrops:

33
Testes, Bone, Brain

Animal Models for Endolymphatic Hydrops or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Endolymphatic Hydrops:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8PHEX, NOS2, ADD1, ADD2, CLDN9, AVP
2MP:00053787.7AVPR2, HSPA4L, AQP7, AQP2, ADD1, NOS2
3MP:00053867.6AVPR2, AVP, CLDN9, AQP2, ADD2, NOS2
4MP:00107687.6AVPR2, AVP, HSPA4L, AQP2, ADD1, NOS2
5MP:00053977.5AVPR2, AQP2, ADD2, ADD1, ADD3, NOS2
6MP:00053677.3PHEX, AVPR2, AVP, HSPA4L, AQP7, AQP2
7MP:00053766.8AVPR2, AVP, HSPA4L, AQP7, AQP2, ADD2

Publications for Endolymphatic Hydrops

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52PubMed
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Articles related to Endolymphatic Hydrops:

(show top 50)    (show all 386)
idTitleAuthorsYear
1
Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease. (23106485)
2013
2
Changes in cochlear function during acute endolymphatic hydrops development in guinea pigs. (23270618)
2013
3
Diagnostic value of three-dimensional magnetic resonance imaging of inner ear after intratympanic gadolinium injection, and clinical application of magnetic resonance imaging scoring system in patients with delayed endolymphatic hydrops. (24355544)
2013
4
Geometrical and volume changes of the membranous vestibular labyrinth in guinea pigs with endolymphatic hydrops. (23817074)
2013
5
The use of vestibular test battery to identify the stages of delayed endolymphatic hydrops. (22753613)
2012
6
Endolymphatic hydrops in Meniere's disease detected by MRI after intratympanic administration of gadolinium: comparison with sudden deafness. (21344957)
2011
7
Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging. (19540682)
2010
8
Magnetic resonance imaging of guinea pig cochlea after vasopressin-induced or surgically induced endolymphatic hydrops. (20115985)
2010
9
Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential. (20105111)
2010
10
Grading of endolymphatic hydrops using magnetic resonance imaging. (19221900)
2009
11
Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops. (19638944)
2009
12
Autoantibodies against inner ear proteins in patients with delayed endolymphatic hydrops and unilateral juvenile deafness. (16428186)
2006
13
In vivo visualization of endolymphatic hydrops in guinea pigs: magnetic resonance imaging evaluation at 4.7 tesla. (16240939)
2005
14
Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? (15699723)
2005
15
Vestibular evoked myogenic potentials and distortion-product otoacoustic emissions combined with glycerol testing in endolymphatic hydrops: their value in early diagnosis. (15633904)
2004
16
The effects of V2 antagonist (OPC-31260) on endolymphatic hydrops. (12948596)
2003
17
Correlation between hearing loss and scala media area in guinea pigs with long-standing endolymphatic hydrops. (12544031)
2003
18
Sildenafil (Viagra) and endolymphatic hydrops. (10993474)
2000
19
Endolymphatic hydrops induced by chronic administration of vasopressin. (10675630)
2000
20
A patient with endolymphatic hydrops refractory to shunt surgery. (10935298)
2000
21
Investigation of endolymphatic hydrops by electrocochleography in patients with Cogan's syndrome. (10624058)
1999
22
Tinnitus: Report of Ten Cases of Perilymphatic Fistula and/or Endolymphatic Hydrops Improved by Surgery. (10753357)
1997
23
Na,K-ATPase in the cochlear lateral wall of human temporal bones with endolymphatic hydrops. (8534024)
1995
24
Detection and quantification of endolymphatic hydrops in the guinea pig cochlea by magnetic resonance microscopy. (8576007)
1995
25
Electrocochleography in endolymphatic hydrops using tone-pip and click stimuli. (8174307)
1994
26
Activities of carbonic anhydrase in the cochleae of guinea pigs with early experimental endolymphatic hydrops. (7972543)
1994
27
Endolymphatic hydrops induced by immune response of the endolymphatic sac: relation to perilymph antibody levels. (1416653)
1992
28
Pathohistological study with four kinds of stress stimulations on active endolymphatic hydrops in the guinea pig. (1927366)
1991
29
Scanning electron microscopy of hair cells, stereocilia and cross-linkage systems in experimentally induced endolymphatic hydrops. (1930978)
1991
30
Intraoperative electrocochleographic monitoring of inner ear surgery for endolymphatic hydrops. A review of cases. (1843172)
1991
31
Delayed endolymphatic hydrops and its relationship to MeniAcre's disease. (2241008)
1990
32
Experimental endolymphatic hydrops: are cochlear and vestibular symptoms caused by increased endolymphatic pressure? (2350132)
1990
33
Endolymphatic hydrops after fenestration: a temporal bone study with implications on the function of the utriculo-endolymphatic valve. (2596627)
1989
34
Electrocochleographic changes in endolymphatic hydrops induced by type II collagen immunization through the stylomastoid foramen. (2751214)
1989
35
Modulation of melanocytes during experimentally induced endolymphatic hydrops. (3150569)
1988
36
Endolymphatic hydrops in perilymphatic fistula. (3618175)
1987
37
Changes in Ca++ activity and DC potential in experimentally induced endolymphatic hydrops. (2424416)
1986
38
Endolymphatic hydrops: can it be controlled? (3947002)
1986
39
Endolymphatic hydrops in guinea pigs after cauterizing the sac with silver nitrate. (3872655)
1985
40
The effect of kanamycin on experimentally induced endolymphatic hydrops. (6732613)
1984
41
Detection of delayed endolymphatic hydrops by the furosemide test. (6591711)
1984
42
Classification of endolymphatic hydrops. (6517142)
1984
43
Single cochlear fibre responses in guinea pigs with long-term endolymphatic hydrops. (6746423)
1984
44
Inner ear fluids dynamics and endolymphatic hydrops. (6591707)
1984
45
Experimental endolymphatic hydrops in sharks. I. Histologic studies. (6458211)
1981
46
Quantitative study of Scarpa's ganglion and vestibular sense organs in endolymphatic hydrops. (6971592)
1981
47
Pathology of endolymphatic hydrops. (7441041)
1980
48
Endolymphatic hydrops and otitis media. (423652)
1979
49
Surgery of endolymphatic hydrops. (4539090)
1972
50
Diagnosis and treatment of endolymphatic hydrops (MAcniA"re's disease). (20277558)
1947

Variations for Endolymphatic Hydrops

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Expression for genes affiliated with Endolymphatic Hydrops

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endolymphatic Hydrops

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Pathways for genes affiliated with Endolymphatic Hydrops

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50PathCards, 30KEGG, 55Reactome, 60Thomson Reuters
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Pathways related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AVPR2, AVP, AQP2
2
Show member pathways
9.0MIP, AQP2, AQP7, AVP, AVPR2
3
Show member pathways
7.9MIP, ADD1, ADD2, AQP2, AQP7, AVP

Compounds for genes affiliated with Endolymphatic Hydrops

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61Tocris Bioscience, 45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp6110.2AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin6110.2AVPR2, AVP
3[arg8]-vasopressin6110.2AVPR2, AVP
4hgcl24510.2MIP, AQP2
5sr 4905961 2911.2AVP, AVPR2
6abscisic acid4510.1MIP, AVP
7mercury4510.1MIP, AQP2
8hg2+2910.0MIP, AQP2, AQP7
9desmopressin45 61 29 1113.0AVPR2, AVP, AQP2
10hydrochlorothiazide45 29 51 24 1113.9AQP2, ADD1
11glycerol45 24 1111.8MIP, AQP2, AQP7
12furosemide45 61 29 51 24 1114.7AQP2, ADD1
13chloride459.7MIP, AQP2, AVP, AVPR2
14urea45 24 1111.6HSPA4L, AQP2, MIP
15potassium45 24 1111.5MIP, ADD1, AQP2, AVPR2
16dexamethasone45 51 29 1112.3NOS2, MIP, AQP2, AVP
17glucose459.3MIP, ADD1, AQP2, AVP
18arginine459.3AVPR2, AVP, AQP2, MIP, NOS2
19glutamate459.2AVPR2, AVP, MIP, NOS2
20nitric oxide45 24 1111.2AVP, AQP2, ADD1, MIP, NOS2
21cysteine459.1MIP, AQP2, AVP, AVPR2
22sodium45 249.2PHEX, AVPR2, AVP, AQP2, ADD2, ADD1
23calcium45 51 24 1110.3AVPR2, AVP, CLDN9, AQP2, ADD2, ADD1

GO Terms for genes affiliated with Endolymphatic Hydrops

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16Gene Ontology
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Cellular components related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1F-actin capping protein complexGO:0082909.3ADD1, ADD2
2plasma membraneGO:0058866.5PHEX, AVPR2, CLDN9, AQP7, AQP2, ADD2

Biological processes related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP7, AQP2
2positive regulation of systemic arterial blood pressureGO:00308410.0AVP, AVPR2
3generation of precursor metabolites and energyGO:0060919.9AQP7, AVP
4cell volume homeostasisGO:0068849.8AQP2, ADD1
5excretionGO:0075889.8AVPR2, AQP7, AQP2
6barbed-end actin filament cappingGO:0510169.3ADD2, ADD1
7water transportGO:0068339.3MIP, AQP2, AQP7, AVP, AVPR2
8transmembrane transportGO:0550859.2MIP, AQP2, AQP7, AVP, AVPR2
9actin filament bundle assemblyGO:0510179.2ADD1, ADD2
10positive regulation of protein bindingGO:0320929.0ADD1, ADD2

Molecular functions related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water channel activityGO:0152509.8MIP, AQP7
2spectrin bindingGO:0305079.0ADD1, ADD2
3structural molecule activityGO:0051988.8ADD1, ADD2, CLDN9
4actin bindingGO:0037798.5AQP2, ADD2, ADD1, ADD3
5calmodulin bindingGO:0055168.2NOS2, MIP, ADD3, ADD1, ADD2

Products for genes affiliated with Endolymphatic Hydrops

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  • Antibodies
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Sources for Endolymphatic Hydrops

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet