MCID: END060
MIFTS: 38

Endolymphatic Hydrops malady

Summaries for Endolymphatic Hydrops

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Ménière\'s disease /meɪnˈjɛərz/ is a disorder of the inner ear that can affect hearing and balance... more...

MalaCards: Endolymphatic Hydrops is related to perilymphatic fistula and otosclerosis. An important gene associated with Endolymphatic Hydrops is MIP (major intrinsic protein of lens fiber), and among its related pathways are Vasopressin-like receptors and NO-dependent CFTR activation (normal and CF). The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and trigeminal ganglion, and related mouse phenotypes are mortality/aging and renal/urinary system.

Aliases & Classifications for Endolymphatic Hydrops

Sources:
10DISEASES, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

endolymphatic hydrops 10 45 61


Related Diseases for Endolymphatic Hydrops

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Endolymphatic Hydrops:



Diseases related to endolymphatic hydrops

Clinical Features for Endolymphatic Hydrops

Drugs & Therapeutics for Endolymphatic Hydrops

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endolymphatic Hydrops

Drug clinical trials:

Search ClinicalTrials for Endolymphatic Hydrops

Search NIH Clinical Center for Endolymphatic Hydrops

Search CenterWatch for Endolymphatic Hydrops

Genetic Tests for Endolymphatic Hydrops

Anatomical Context for Endolymphatic Hydrops

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Endolymphatic Hydrops:

33
Brain, T cells, Trigeminal ganglion

Animal Models for Endolymphatic Hydrops or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Endolymphatic Hydrops

Sources:
51PubMed
See all sources

Articles related to Endolymphatic Hydrops:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss. (23921924)
2013
2
Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI. (23768010)
2013
3
Effects of endolymphatic sac decompression surgery on endolymphatic hydrops. (24245698)
2013
4
Visualization of endolymphatic hydrops in MAcniA"re's disease after intravenous administration of single-dose gadodiamide at 1.5T. (23666156)
2013
5
Endolymphatic hydrops in MAcniA"re's disease: cause, consequence, or epiphenomenon? (23921917)
2013
6
Visualization of endolymphatic hydrops in MAcniA"re's disease after single-dose intravenous gadolinium-based contrast medium: timing of optimal enhancement. (22450386)
2012
7
Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene receptor antagonist. (22699994)
2012
8
Association between endolymphatic hydrops as revealed by magnetic resonance imaging and caloric response. (22072257)
2011
9
Long-term effects of the Meniett device in Japanese patients with Meniere's disease and delayed endolymphatic hydrops reported by the Middle Ear Pressure Treatment Research Group of Japan. (21319947)
2011
10
Endolymphatic hydrops: pathophysiology and experimental models. (20713237)
2010
11
Endolymphatic hydrops in otologic syphilis: a temporal bone study. (20431499)
2010
12
Visualization of endolymphatic hydrops in MAcniA"re's disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR. (21187694)
2010
13
Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops. (19638944)
2009
14
Large vestibular aqueduct syndrome and endolymphatic hydrops: two presentations of a common primary inner-ear dysfunction? (19000343)
2009
15
Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease. (19863332)
2009
16
Endolymphatic space imaging in patients with delayed endolymphatic hydrops. (19863306)
2009
17
Unusual cases of delayed endolymphatic hydrops. (17453453)
2007
18
In vivo visualization of endolymphatic hydrops in guinea pigs: magnetic resonance imaging evaluation at 4.7 tesla. (16240939)
2005
19
Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs. (15668526)
2004
20
Early diagnosis of endolymphatic hydrops with distortion. Product otoacoustic emissions. (15185614)
2004
21
Acute endolymphatic hydrops generated by exposure of the ear to nontraumatic low-frequency tones. (15357421)
2004
22
Induction of endolymphatic hydrops by directly infused monoclonal antibody against type II collagen CB11 peptide. (12126013)
2002
23
Endolymphatic hydrops in asymptomatic ears in unilateral MAcniA"re's disease. (11359166)
2001
24
Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops. (11192876)
2001
25
Different regulation of connexin26 and ZO-1 in cochleas of developing rats and of guinea pigs with endolymphatic hydrops. (11304795)
2001
26
Meniere's disease and endolymphatic hydrops without Meniere's symptoms: temporal bone histopathology. (10380731)
1999
27
Studies of cochlear blood flow in guinea pigs with endolymphatic hydrops. (9519374)
1998
28
Two-phase endolymphatic hydrops: a new dynamic guinea pig model. (9039474)
1997
29
Immune-mediated sensorineural hearing loss with or without endolymphatic hydrops: a clinical and experimental approach. (9616677)
1997
30
Treatment of ipsilateral delayed endolymphatic hydrops. (9288253)
1997
31
The efficacy of tympanic electrocochleography in the diagnosis of endolymphatic hydrops. (8841707)
1996
32
Mumps labyrinthitis, endolymphatic hydrops and sudden deafness in succession in the same ear. (8958544)
1996
33
Detection and quantification of endolymphatic hydrops in the guinea pig cochlea by magnetic resonance microscopy. (8576007)
1995
34
Delayed endolymphatic hydrops: clinical manifestations and treatment outcome. (8548962)
1995
35
Electrocochleography in endolymphatic hydrops using tone-pip and click stimuli. (8174307)
1994
36
Electrocochleography in experimental endolymphatic hydrops. (8128868)
1994
37
Changes in immunostaining of cochleas with experimentally induced endolymphatic hydrops. (8203812)
1994
38
Experimental endolymphatic hydrops and glycerol. Electrophysiologic study. (8352482)
1993
39
Tympanic electrocochleography for evaluation of endolymphatic hydrops. (1602909)
1992
40
Transport of HRP through Reissner's membrane in experimental endolymphatic hydrops. (1759573)
1991
41
Vascular permeability of the stria vascularis in experimental endolymphatic hydrops. (1927370)
1991
42
Old theme and new reflections: hearing impairment associated with endolymphatic hydrops. (2061203)
1991
43
Immunoglobulin E and circulating immune complexes in endolymphatic hydrops. (2024904)
1991
44
Investigation of the physiological basis of summating potential changes in endolymphatic hydrops. (3389106)
1988
45
Detection of delayed endolymphatic hydrops by the furosemide test. (6591711)
1984
46
Auditory evoked potentials--the cochlear summating potential in detection of endolymphatic hydrops. (6517133)
1984
47
Detection of endolymphatic hydrops by the administration of furosemid. (4807555)
1973
48
Surgery of endolymphatic hydrops. (4539090)
1972
49
The treatment of endolymphatic hydrops (MAcniA"re's disease) with streptomycin. (14885912)
1951
50
The syndrome of physical or intrinsic allergy of the head; vasomotor rhinitis and the vasodilating pain syndrome, their relationship to myalgia and endolymphatic hydrops (MAcniA"re's disease) and the reasons for including all four as the syndrome of physical allergy of the head. (21012897)
1946

Genetic Variations for Endolymphatic Hydrops

Expression for genes affiliated with Endolymphatic Hydrops

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endolymphatic Hydrops

Search GEO for disease gene expression data for Endolymphatic Hydrops.

Pathways for genes affiliated with Endolymphatic Hydrops

Sources:
54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AVP, AVPR2
2
NO-dependent CFTR activation (normal and CF)
9.8NOS2, SCNN1A
39.8AVPR2, AVP, AQP2
49.8MIP, AQP2, AQP7
5
Hide members
9.0SCNN1A, MIP, AVPR2, AVP, AQP2, AQP7
6
Hide members
8.8AQP2, ADD1, ADD2, AVP, AVPR2, MIP

Compounds for genes affiliated with Endolymphatic Hydrops

Sources:
60Tocris Bioscience, 45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp6010.3AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin6010.3AVPR2, AVP
3[arg8]-vasopressin6010.3AVPR2, AVP
4hgcl24510.3AQP2, MIP
5sr 4905960 2911.3AVP, AVPR2
6desmopressin45 60 29 1113.1AVPR2, AVP, AQP2
7hg2+2910.1MIP, AQP2, AQP7
8mercury4510.0AQP2, MIP
9pcmbs4510.0DNAH8, MIP
10chloride459.9MIP, AVPR2, AVP, AQP2
11thiazide459.9ADD1, SCNN1A
12urea45 11 2411.7HSPA4L, MIP, AQP2
13abscisic acid459.7MIP, AVP
14potassium45 11 2411.7AQP2, ADD1, AVPR2, MIP
15ether459.6DNAH8, AVP
16glycerol45 11 2411.6AQP7, AQP2, MIP, DNAH8
17dexamethasone45 50 29 1112.3SCNN1A, MIP, AVP, NOS2, AQP2
18nitric oxide45 11 2411.3AQP2, ADD1, NOS2, AVP, MIP
19arginine459.0DNAH8, MIP, AVPR2, AVP, NOS2, AQP2
20glutamate459.0DNAH8, MIP, AVPR2, AVP, NOS2
21sodium45 249.5AQP2, ADD1, ADD2, AVP, AVPR2, MIP
22calcium45 50 11 2410.6PHEX, DNAH8, MIP, CLDN9, AVPR2, AVP

GO Terms for genes affiliated with Endolymphatic Hydrops

Sources:
16Gene Ontology
See all sources

Cellular components related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1F-actin capping protein complexGO:0082909.7ADD1, ADD2
2plasma membraneGO:0058866.6AQP7, SCNN1A, PHEX, CRLF1, MIP, CLDN9

Biological processes related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP7, AQP2
2positive regulation of systemic arterial blood pressureGO:00308410.0AVPR2, AVP
3cell volume homeostasisGO:0068849.7AQP2, ADD1
4actin filament bundle assemblyGO:0510179.7ADD1, ADD2
5excretionGO:0075889.6SCNN1A, AVPR2, AQP2, AQP7
6barbed-end actin filament cappingGO:0510169.6ADD1, ADD2
7water transportGO:0068339.5AQP7, AQP2, AVP, AVPR2, MIP
8transmembrane transportGO:0550859.1SCNN1A, MIP, AVPR2, AVP, AQP2, AQP7

Molecular functions related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water channel activityGO:0152509.7AQP7, MIP
2spectrin bindingGO:0305079.7ADD1, ADD2
3calmodulin bindingGO:0055168.5ADD1, ADD2, ADD3, NOS2, MIP
4actin bindingGO:0037798.4SCNN1A, ADD3, ADD2, ADD1, AQP2

Products for genes affiliated with Endolymphatic Hydrops

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endolymphatic Hydrops

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet