MCID: END060
MIFTS: 41

Endolymphatic Hydrops malady

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Summaries for Endolymphatic Hydrops

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MalaCards based summary: Endolymphatic Hydrops is related to meniere's disease and labyrinthitis. An important gene associated with Endolymphatic Hydrops is MIP (major intrinsic protein of lens fiber), and among its related pathways are Vasopressin-regulated water reabsorption and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related mouse phenotypes are nervous system and growth/size/body.

Aliases & Classifications for Endolymphatic Hydrops

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Sources:
10DISEASES, 44Novoseek, 62UMLS
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Endolymphatic Hydrops, Aliases & Descriptions:

Name: Endolymphatic Hydrops 10 44 62


Related Diseases for Endolymphatic Hydrops

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Graphical network of the top 20 diseases related to Endolymphatic Hydrops:



Diseases related to endolymphatic hydrops

Symptoms for Endolymphatic Hydrops

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Drugs & Therapeutics for Endolymphatic Hydrops

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Drug clinical trials:

Search ClinicalTrials for Endolymphatic Hydrops

Search NIH Clinical Center for Endolymphatic Hydrops

Genetic Tests for Endolymphatic Hydrops

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Anatomical Context for Endolymphatic Hydrops

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MalaCards organs/tissues related to Endolymphatic Hydrops:

32
Testes, Bone, Brain

Animal Models for Endolymphatic Hydrops or affiliated genes

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MGI Mouse Phenotypes related to Endolymphatic Hydrops:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8PHEX, NOS2, ADD1, ADD2, CLDN9, AVP
2MP:00053787.7AVPR2, HSPA4L, AQP7, AQP2, ADD1, NOS2
3MP:00053867.6AVPR2, AVP, CLDN9, AQP2, ADD2, NOS2
4MP:00107687.6AVPR2, AVP, HSPA4L, AQP2, ADD1, NOS2
5MP:00053977.5AVPR2, AQP2, ADD2, ADD1, ADD3, NOS2
6MP:00053677.3PHEX, AVPR2, AVP, HSPA4L, AQP7, AQP2
7MP:00053766.8AVPR2, AVP, HSPA4L, AQP7, AQP2, ADD2

Publications for Endolymphatic Hydrops

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Articles related to Endolymphatic Hydrops:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of H1-receptor antagonist (olopatadine hydrochloride). (24492133)
2014
2
Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease. (23106485)
2013
3
Changes in cochlear function during acute endolymphatic hydrops development in guinea pigs. (23270618)
2013
4
Diagnostic value of three-dimensional magnetic resonance imaging of inner ear after intratympanic gadolinium injection, and clinical application of magnetic resonance imaging scoring system in patients with delayed endolymphatic hydrops. (24355544)
2013
5
Geometrical and volume changes of the membranous vestibular labyrinth in guinea pigs with endolymphatic hydrops. (23817074)
2013
6
Three-dimensional visualization of endolymphatic hydrops after intravenous administration of single-dose gadodiamide. (23666157)
2013
7
The use of vestibular test battery to identify the stages of delayed endolymphatic hydrops. (22753613)
2012
8
Endolymphatic hydrops in Meniere's disease detected by MRI after intratympanic administration of gadolinium: comparison with sudden deafness. (21344957)
2011
9
Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging. (19540682)
2010
10
Magnetic resonance imaging of guinea pig cochlea after vasopressin-induced or surgically induced endolymphatic hydrops. (20115985)
2010
11
Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential. (20105111)
2010
12
Grading of endolymphatic hydrops using magnetic resonance imaging. (19221900)
2009
13
Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops. (19638944)
2009
14
Autoantibodies against inner ear proteins in patients with delayed endolymphatic hydrops and unilateral juvenile deafness. (16428186)
2006
15
In vivo visualization of endolymphatic hydrops in guinea pigs: magnetic resonance imaging evaluation at 4.7 tesla. (16240939)
2005
16
Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? (15699723)
2005
17
Vestibular evoked myogenic potentials and distortion-product otoacoustic emissions combined with glycerol testing in endolymphatic hydrops: their value in early diagnosis. (15633904)
2004
18
The effects of V2 antagonist (OPC-31260) on endolymphatic hydrops. (12948596)
2003
19
Correlation between hearing loss and scala media area in guinea pigs with long-standing endolymphatic hydrops. (12544031)
2003
20
Sildenafil (Viagra) and endolymphatic hydrops. (10993474)
2000
21
Endolymphatic hydrops induced by chronic administration of vasopressin. (10675630)
2000
22
A patient with endolymphatic hydrops refractory to shunt surgery. (10935298)
2000
23
Investigation of endolymphatic hydrops by electrocochleography in patients with Cogan's syndrome. (10624058)
1999
24
Na,K-ATPase in the cochlear lateral wall of human temporal bones with endolymphatic hydrops. (8534024)
1995
25
Detection and quantification of endolymphatic hydrops in the guinea pig cochlea by magnetic resonance microscopy. (8576007)
1995
26
Electrocochleography in endolymphatic hydrops using tone-pip and click stimuli. (8174307)
1994
27
Activities of carbonic anhydrase in the cochleae of guinea pigs with early experimental endolymphatic hydrops. (7972543)
1994
28
Endolymphatic hydrops induced by immune response of the endolymphatic sac: relation to perilymph antibody levels. (1416653)
1992
29
Pathohistological study with four kinds of stress stimulations on active endolymphatic hydrops in the guinea pig. (1927366)
1991
30
Scanning electron microscopy of hair cells, stereocilia and cross-linkage systems in experimentally induced endolymphatic hydrops. (1930978)
1991
31
Intraoperative electrocochleographic monitoring of inner ear surgery for endolymphatic hydrops. A review of cases. (1843172)
1991
32
Delayed endolymphatic hydrops and its relationship to MeniAcre's disease. (2241008)
1990
33
Experimental endolymphatic hydrops: are cochlear and vestibular symptoms caused by increased endolymphatic pressure? (2350132)
1990
34
Endolymphatic hydrops after fenestration: a temporal bone study with implications on the function of the utriculo-endolymphatic valve. (2596627)
1989
35
Electrocochleographic changes in endolymphatic hydrops induced by type II collagen immunization through the stylomastoid foramen. (2751214)
1989
36
Modulation of melanocytes during experimentally induced endolymphatic hydrops. (3150569)
1988
37
Endolymphatic hydrops in perilymphatic fistula. (3618175)
1987
38
Changes in Ca++ activity and DC potential in experimentally induced endolymphatic hydrops. (2424416)
1986
39
Endolymphatic hydrops: can it be controlled? (3947002)
1986
40
Endolymphatic hydrops in guinea pigs after cauterizing the sac with silver nitrate. (3872655)
1985
41
The effect of kanamycin on experimentally induced endolymphatic hydrops. (6732613)
1984
42
Detection of delayed endolymphatic hydrops by the furosemide test. (6591711)
1984
43
Classification of endolymphatic hydrops. (6517142)
1984
44
Inner ear fluids dynamics and endolymphatic hydrops. (6591707)
1984
45
Experimental endolymphatic hydrops in sharks. I. Histologic studies. (6458211)
1981
46
Quantitative study of Scarpa's ganglion and vestibular sense organs in endolymphatic hydrops. (6971592)
1981
47
Pathology of endolymphatic hydrops. (7441041)
1980
48
Endolymphatic hydrops and otitis media. (423652)
1979
49
Surgery of endolymphatic hydrops. (4539090)
1972
50
Diagnosis and treatment of endolymphatic hydrops (MAcniA"re's disease). (20277558)
1947

Variations for Endolymphatic Hydrops

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Expression for genes affiliated with Endolymphatic Hydrops

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Expression patterns in normal tissues for genes affiliated with Endolymphatic Hydrops

Search GEO for disease gene expression data for Endolymphatic Hydrops.

Pathways for genes affiliated with Endolymphatic Hydrops

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Pathways related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AVPR2, AVP, AQP2
2
Show member pathways
9.0AVPR2, AVP, AQP7, AQP2, MIP
3
Show member pathways
7.9AVPR2, AVP, AQP7, AQP2, ADD2, ADD1

Compounds for genes affiliated with Endolymphatic Hydrops

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Compounds related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp6110.2AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin6110.2AVPR2, AVP
3[arg8]-vasopressin6110.2AVPR2, AVP
4hgcl24410.2MIP, AQP2
5sr 4905961 2811.2AVP, AVPR2
6abscisic acid4410.1MIP, AVP
7mercury4410.1MIP, AQP2
8hg2+2810.0MIP, AQP2, AQP7
9desmopressin44 61 28 1113.0AVPR2, AVP, AQP2
10hydrochlorothiazide44 28 50 24 1113.9AQP2, ADD1
11glycerol44 24 1111.8MIP, AQP2, AQP7
12furosemide44 61 28 50 24 1114.7AQP2, ADD1
13chloride449.7MIP, AQP2, AVP, AVPR2
14urea44 24 1111.6HSPA4L, AQP2, MIP
15potassium44 24 1111.5MIP, ADD1, AQP2, AVPR2
16dexamethasone44 50 28 1112.3NOS2, MIP, AQP2, AVP
17glucose449.3MIP, ADD1, AQP2, AVP
18arginine449.3AVPR2, AVP, AQP2, MIP, NOS2
19glutamate449.2AVPR2, AVP, MIP, NOS2
20nitric oxide44 24 1111.2AVP, AQP2, ADD1, MIP, NOS2
21cysteine449.1MIP, AQP2, AVP, AVPR2
22sodium44 249.2PHEX, AVPR2, AVP, AQP2, ADD2, ADD1
23calcium44 50 24 1110.3AVPR2, AVP, CLDN9, AQP2, ADD2, ADD1

GO Terms for genes affiliated with Endolymphatic Hydrops

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Cellular components related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1F-actin capping protein complexGO:0082909.3ADD1, ADD2
2plasma membraneGO:0058866.5PHEX, AVPR2, CLDN9, AQP7, AQP2, ADD2

Biological processes related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glycerol transportGO:01579310.0AQP7, AQP2
2positive regulation of systemic arterial blood pressureGO:00308410.0AVP, AVPR2
3generation of precursor metabolites and energyGO:0060919.9AQP7, AVP
4cell volume homeostasisGO:0068849.8AQP2, ADD1
5excretionGO:0075889.8AVPR2, AQP7, AQP2
6barbed-end actin filament cappingGO:0510169.3ADD2, ADD1
7water transportGO:0068339.3MIP, AQP2, AQP7, AVP, AVPR2
8transmembrane transportGO:0550859.2MIP, AQP2, AQP7, AVP, AVPR2
9actin filament bundle assemblyGO:0510179.2ADD1, ADD2
10positive regulation of protein bindingGO:0320929.0ADD1, ADD2

Molecular functions related to Endolymphatic Hydrops according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water channel activityGO:0152509.8MIP, AQP7
2spectrin bindingGO:0305079.0ADD1, ADD2
3structural molecule activityGO:0051988.8ADD1, ADD2, CLDN9
4actin bindingGO:0037798.5AQP2, ADD2, ADD1, ADD3
5calmodulin bindingGO:0055168.2NOS2, MIP, ADD3, ADD1, ADD2

Products for genes affiliated with Endolymphatic Hydrops

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  • Antibodies
  • Proteins
  • Lysates

Sources for Endolymphatic Hydrops

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet