Endometrial Cancer malady

Wikipedia: Endometrial cancer refers to several types of malignancies that arise from the endometrium, or lining,...⁴⁴ more...

MalaCards: Endometrial Cancer, also known as endometrial carcinoma, is related to carcinoma and prostatitis. An important gene associated with Endometrial Cancer is MSH6 (mutS homolog 6 (E. coli)), and among its related pathways are Development_IGF-1 receptor signaling and P2Y Receptor Signaling. The compounds estrogen and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, colon and adipocyte, and related mouse phenotypes are homeostasis/metabolism and growth/size.

OMIM: 608089

endometrial cancer 8 33 32 endometrial carcinoma 43

Diseases related to endometrial cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 766)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	71.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
2	prostatitis	64.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
3	adenocarcinoma	58.5	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA1, NCOA3
4	pancreatitis	55.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	cervicitis	51.8	PIK3CA, PIK3CG, PDCD4, RET, KITLG, SFN
6	endometrial carcinoma	51.8	PIK3CB, PIK3CA, PIK3CG, NCOA1, NCOA3, KIAA1324
7	melanoma	49.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
8	ovarian carcinoma	48.1	PIK3CA, PIK3CG, NCOA3, PDCD4, PCNA, RB1
9	colon cancer	47.2	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, PDCD4
10	hypoxia	45.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCOA1
11	epithelial ovarian cancer	45.3	PIK3CB, PIK3CA, PIK3R3, PIK3CG, NCOA1, NCOA3
12	colon carcinoma	43.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDCD4
13	cervical cancer	42.9	PIK3CA, PIK3CG, SFN, PCNA, RB1, RBL2
14	endometriosis	40.9	PIK3CA, NCOA1, KITLG, SFRP4, PCNA, SERPINA6
15	obesity	40.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA3, PCBD1
16	renal cell carcinoma	37.7	PIK3CA, RET, PCNA, SETD2, SERPINB2, VIM
17	breast cancer	37.1	NCOA3, BRCA1, BRCA2, VEGFA, RAD51, KDR
18	cervical carcinoma	36.5	PIK3CA, PIK3CG, KITLG, PCNA, RB1, RBL1
19	polyposis	36.2	PIK3CG, RET, KITLG, PCBD1, PCNA, RB1
20	adenomyosis	34.1	PCNA, VEGFA, LIF, BCL2, MUC16, CDKN1A
21	retinoblastoma	34.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NDC80
22	peritonitis	33.9	RET, KITLG, PCNA, SETD2, SERPINB2, SERPINE1
23	wilms tumor	33.9	RET, PCNA, SETD2, VIM, BRCA1, BRCA2
24	lynch syndrome	33.4	BRAF, MSH2, CDK2, CD44, MLH1, MGMT
25	pancreatic cancer	32.6	RET, SERPINB5, BRCA2, VEGFA, RAF1, BIRC5
26	pituitary tumor	32.2	RB1, LIF, LEPR, CDKN1B, FGF2, FGF4
27	myoma	32.0	KITLG, PCNA, LEP, LEPR, FGF2, CCND1
28	colorectal cancer	32.0	CHEK2, UGT1A1, MTHFR, MSH2, MLH1, GSTM1
29	cervical adenocarcinoma	31.6	PCNA, BRAF, MYC, RASSF1, PARP1, MUC16
30	anemia	31.5	SGOL1, KITLG, SFPQ, PCNA, RB1, SETD2
31	insulin resistance	31.1	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PCBD1
32	ovarian cancer	31.1	RB1, RBL2, RBL1, BRCA1, BRCA2, CHEK2
33	uterine carcinosarcoma	31.0	RB1, VIM, VEGFA, CLDN4, CLDN3, BCL2
34	tuberous sclerosis	30.9	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PCNA, VIM
35	nephroblastoma	30.6	VIM, VEGFC, JUP, CDKN1B, CD44, MME
36	dna topoisomerase ii	30.2	PCNA, BRCA1, MYC, KCNH2, JUN, CDKN1A
37	herpes simplex	29.5	PIK3CA, PIK3CG, PCNA, SERPINE1, VIM, VEGFA
38	endocervicitis	29.5	VIM, MYC, BCL2, MUC16, MSH2, CDK6
39	leukemia	29.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40	hepatocellular carcinoma	28.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCOA3
41	breast carcinoma	28.2	PIK3CA, PIK3R1, PIK3CG, NDC80, NCOA3, KITLG
42	neuronitis	27.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
43	gastric cancer	27.5	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NDC80, NCOA3
44	thyroiditis	26.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA1, NCOA3
45	adenoma	25.7	PIK3CA, NCOA1, NCOA3, PDCD4, RET, KITLG
46	esophagitis	25.1	PIK3CB, PIK3CA, PIK3CG, NCOA3, PDCD4, RET
47	bartter disease	21.8	PIK3CB, PIK3CA, PIK3R1, NCOA3, RET, PCNA
48	myeloid leukemia	21.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
49	sarcoma	21.5	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
50	gonococcal synovitis	21.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA1, KITLG

Clinical features from OMIM: 608089

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to endometrial cancer:

²²

MGI Mouse Phenotypes related to endometrial cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	24.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
2	growth/size phenotype	MP:0005378	23.7	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA1, NCOA3
3	mortality/aging	MP:0010768	23.1	PIK3CB, PIK3CA, PDCD4, RET, KITLG, SFN
4	cellular phenotype	MP:0005384	20.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
5	immune system phenotype	MP:0005387	19.2	PIK3CD, PIK3R5, NCOA1, NCOA3, PDCD4, SFN
6	cardiovascular system phenotype	MP:0005385	19.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
7	digestive/alimentary phenotype	MP:0005381	18.6	NCOA3, RET, KITLG, SFN, SFRP4, RB1
8	normal phenotype	MP:0002873	18.0	PIK3R1, RET, BTC, RBL2, RBL1, BRAF
9	nervous system phenotype	MP:0003631	17.9	NCOA1, KITLG, RB1, RBL2, RBL1, BRAF
10	hematopoietic system phenotype	MP:0005397	17.9	SFN, PCNA, RBL1, SERPINB2, BRAF, BRCA1
11	skeleton phenotype	MP:0005390	17.6	PIK3CD, PIK3CG, NCOA1, KITLG, SFN, BTC
12	integument phenotype	MP:0010771	17.2	PIK3CG, NCOA1, NCOA3, KITLG, SFN, PCBD1
13	behavior/neurological phenotype	MP:0005386	17.0	PIK3CA, NCOA1, NCOA3, RB1, RBL1, SERPINA6
14	tumorigenesis	MP:0002006	16.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, NCOA3, PDCD4
15	embryogenesis phenotype	MP:0005380	16.4	PIK3CB, PIK3CA, NCOA1, NCOA3, RET, SFN
16	renal/urinary system phenotype	MP:0005367	16.2	NCOA1, NCOA3, PDCD4, RET, SFRP4, PCBD1
17	reproductive system phenotype	MP:0005389	15.3	PIK3CA, NCOA1, NCOA3, PDCD4, RET, SFN
18	vision/eye phenotype	MP:0005391	15.0	PIK3CA, KITLG, SFN, PCBD1, RB1, RBL2
19	craniofacial phenotype	MP:0005382	14.7	NCOA3, KITLG, RBL1, BMI1, BMPR1A, LLGL1
20	limbs/digits/tail phenotype	MP:0005371	14.6	RET, KITLG, SFN, RB1, RBL2, RBL1
21	no phenotypic analysis	MP:0003012	14.5	PIK3CD, PIK3R1, RET, PCNA, RB1, RBL2
22	endocrine/exocrine gland phenotype	MP:0005379	14.2	NCOA1, PDCD4, RET, SFN, RBL2, RBL1
23	muscle phenotype	MP:0005369	14.0	PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCOA3, RET
24	adipose tissue phenotype	MP:0005375	13.4	PIK3CA, PIK3R1, NCOA3, RB1, RBL1, SERPINE1
25	liver/biliary system phenotype	MP:0005370	13.1	NCOA3, SFN, RBL1, SERPINA6, VEGFA, RAMP2
26	respiratory system phenotype	MP:0005388	12.4	RET, SFRP4, BRCA1, LPAR2, BMPR1A, LIF
27	hearing/vestibular/ear phenotype	MP:0005377	12.1	NCOA3, KITLG, SFN, RB1, MYC, BMPR1A
28	pigmentation phenotype	MP:0001186	11.8	KITLG, PCBD1, RB1, BRAF, BRCA1, MYC
29	other phenotype	MP:0005395	11.4	KDR, LEPR, AXIN1, JAK2, CDKN2A, ITGB1

Articles related to endometrial cancer:

(show top 50)    (show all 824)

id	Title	Authors	Year	Affiliating Genes
1	Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy. (19822355)	Cantrell L.A.... Bae-Jump V.L.	2010	PRKAB1
2	Telomere length and genetic analyses in population-ba sed studies of endometrial cancer risk. (20549820)	Prescott J.... De Vivo I.	2010	TERT, TNKS2, TERF1
3	Altered sphingolipid metabolism in human endometrial cancer. (20226264)	Knapp P.... GA^rski J.	2010	SPHK1
4	Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. (19124504)	Setiawan V.W.... Olson S.H.	2009	CYP19A1
5	The CXCR4/CXCL12 axis in endometrial cancer. (19199057)	Gelmini S.... Orlando C.	2009	CXCR4, CXCL12
6	Aromatase, cyclooxygenase 2, HER-2/neu, and p53 as pr ognostic factors in endometrioid endometrial cancer. (19509570)	Jongen V.H.... Nijman H.W.	2009	ERBB2, TP53, CYP19A1
7	Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host sur vival. (19724908)	Takahashi K.... Suzuki M.	2009	EGFR, VEGFA
8	In vitro evaluation of the effects of gefitinib on the cytotoxic activity of selected anticancer agents in a panel of human endometrial cancer cell lines. (18753181)	Gaikwad A.... Smith J.A.	2009	ABCF2
9	Effects and mechanisms of 5-aza-2'-deoxycytidine on endometrial cancer cell. (20079041)	Zhang Y.Q.... Sheng N.	2009	RASSF1
10	Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. (18632614)	Daikoku T.... Dey S.K.	2008	PTEN
11	Variants in hormone biosynthesis genes and risk of endometrial cancer. (18437511)	Olson S.H.... Zauber A.G.	2008	CYP19A1, CYP17A1, CYP11A1
12	In vitro evaluation of the growth inhibition and apoptosis effect of mifepristone (RU486) in human Ishikawa and HEC1A endometrial cancer cell lines. (18004570)	Navo M.A.... Ramondetta L.M.	2008	BCL2, BAX, PTGS2
13	Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. (17925543)	Lu K.H.... Broaddus R.R.	2007	MSH2, MLH1, MSH6
14	Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. (17303224)	Jiang S.... Jiang S.W.	2007	CASP9
15	Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. (17332319)	Moreno-Bueno G.... Palacios J.	2007	CTNNB1, KRAS, CDKN3
16	An investigation of relationships between hypoxia-inducible factor-1 alpha gene polymorphisms and ovarian, cervical and endometrial cancers. (17418979)	Konac E.... Ekmekci A.	2007	HIF1A
17	Progesterone receptor (PROGINS) polymorphism and the risk of endometrial cancer development. (17291258)	Junqueira M.G.... Goncalves W.J.	2007	PGR, NR3C1
18	Intermediate-conductance-Ca2+-activated K+ channels are overexpressed in endometrial cancer and involved in regulating proliferation of endometrial cancer cells (17442186)	Wang Z.H.... Yi X.F.	2007	KCNN4
19	P53/MDM2 overexpression in metastatic endometrial cancer: correlation with clinicopathological features and patient outcome. (17671841)	Jeczen R.... Semczuk A.	2007	MDM2, TP53
20	Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer. (17089036)	Banno K.... Aoki D.	2006	CDH1, APC, MLH1
21	Nm23 expression in node-positive and node-negative endometrial cancer. (16919631)	YalAsinkaya U.... Demir D.	2006	NME1
22	Trastuzumab therapy for tamoxifen-stimulated endometrial cancer. (16166331)	Osipo C.... Jordan V.C.	2005	ERBB2, MYC, PSEN2
23	Molecular genetic characterization of tamoxifen-associated endometrial cancer. (15589576)	Prasad M.... Ellenson L.H.	2005	TP53, CTNNB1, PTEN
24	Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer. (16322283)	Deng L.... Davies P.J.A.	2005	KIAA1324
25	Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer. (15585630)	Woo M.M.... Auersperg N.	2004	PTEN, OVGP1
26	Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells. (15505622)	Jin X.... Lin J.	2004	PTEN, CDKN3
27	Arzoxifene as therapy for endometrial cancer. (12928005)	Burke T.W.... Walker C.L.	2003	ESR1
28	Membrane-associated serine/threonine protein phosphatase in endometrial cancer. (14710095)	Sugiyama M.... Tamaya T.	2003	PPP2R4, CDKN3
29	Mechanisms involved in the evolution of progestin resistance in human endometrial hyperplasia--precursor of endometrial cancer. (12586588)	Wang S.... Zheng W.	2003	FASLG
30	KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. (12684410)	Liu F.S.... Chiou L.C.	2003	CD82
31	Progestogenic effects of tibolone on human endometrial cancer cells. (12727992)	Blok L.J.... Burger C.W.	2003	IGFBP3
32	Detection of endometrial cancer by determination of matrix metalloproteinases in the uterine cavity. (12893193)	Lopata A.... Salamonsen L.A.	2003	MMP2
33	PTEN expression in tamoxifen-associated endometrial cancers. (12530022)	Holtz D.... Broaddus R.R.	2002	TP53, PTEN
34	Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. (11957147)	Fujiwaki R.... Miyazaki K.	2002	VEGFA, PTGS2, TYMP
35	Lycopene inhibition of cell cycle progression in brea st and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes. (11423993)	Nahum A.... Sharoni Y.	2001	CCND1, IFI27
36	Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen. (11036892)	Bergman L.... van Leeuwen F.E.	2000	TP53
37	Anti-CD9 monoclonal antibody-stimulated invasion of endometrial cancer cell lines in vitro: possible inhibitory effect of CD9 in endometrial cancer invasion. (10908282)	Park K.R.... Fujii S.	2000	CD9
38	Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells. (10411295)	Castro-Rivera E.... Safe S.	1999	CTSD, ESR1, AHR
39	WAF1 genotype and endometrial cancer susceptibility. (10021299)	Hachiya T.... Wake N.	1999	CDKN1A
40	Effects of sex steroid hormones on corticosteroid-binding globulin gene expression in human endometrial cancer cell line Ishikawa. (9768330)	Misao R.... Tamaya T.	1998	SERPINA6
41	MTAP gene deletion in endometrial cancer. (9623796)	Wong Y.F.... Chang A.M.	1998	MTAP
42	Epidermal growth factor activates protein kinase C in the human endometrial cancer cell line HEC-1-A. (9345355)	Connor P.... Menon K.M.	1997	EGF
43	Involvement of annexin V in antiproliferative effects of gonadotropin-releasing hormone agonists on human endometrial cancer cell line. (9264565)	Shibata S.... Tanaka T.	1997	ANXA5, GNRHR, GNRH1
44	The prognostic significance of progesterone receptor level in endometrial cancer (9045451)	Nyholm H.C.... Nielsen A.L.	1997	PGR
45	Clinicopathological characteristics of p53 overexpression in endometrial cancers. (8014010)	Inoue M.... Ueshima H.	1994	TP53
46	Expression of luteinizing hormone releasing hormone and its mRNA in human endometrial cancer cell lines. (8077383)	Irmer G.... Emons G.	1994	GNRH1
47	Estrogen productivity of endometrium and endometrial cancer tissue; influence of aromatase on proliferation of endometrial cancer cells. (8476761)	Yamamoto T.... Terashima Y.	1993	CYP19A1, ARSH
48	The plasminogen activator urokinase and its inhibitor PAI-2 in endometrial cancer. (1427403)	Gleeson N.... Bonnar J.	1992	PLAU, SERPINB2
49	HER-2/neu expression: a major prognostic factor in endometrial cancer. (1361478)	Hetzel D.J.... Podratz K.C.	1992	ERBB2
50	Specific binding sites for insulin and insulin-like growth factor I in human endometrial cancer. (1721487)	Nagamani M.... Doherty M.G.	1991	IGF1

Genes related to endometrial cancer according to GeneCards:

(show top 50)    (show all 543)

id	Symbol	Description	Score	GeneCards Section Context
1	MSH6	mutS homolog 6 (E. coli)	11.1	Publications, Summaries
2	ESR1	estrogen receptor 1	11.1	Publications, Summaries
3	MSH3	mutS homolog 3 (E. coli)	11.1	Publications, Summaries
4	PGR	progesterone receptor	11.0	Publications
5	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
6	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
7	MUC16	mucin 16, cell surface associated	11.0	Publications
8	S100A6	S100 calcium binding protein A6	11.0	Publications
9	MMP26	matrix metallopeptidase 26	11.0	Publications
10	ARSH	arylsulfatase family, member H	11.0	Publications
11	CLDN3	claudin 3	11.0	Publications
12	CLDN4	claudin 4	11.0	Publications
13	FGF3	fibroblast growth factor 3	11.0	Publications
14	FGF4	fibroblast growth factor 4	11.0	Publications
15	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
16	PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	11.0	Publications
17	PTEN	phosphatase and tensin homolog	11.0	Publications, Pathways & Interactions
18	SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	11.0	Publications
19	TYMP	thymidine phosphorylase	11.0	Publications
20	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
21	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.0	Publications
22	EBAG9	estrogen receptor binding site associated, antigen, 9	11.0	Publications
23	ESRRA	estrogen-related receptor alpha	11.0	Publications
24	GNRHR	gonadotropin-releasing hormone receptor	11.0	Publications
25	HPR	haptoglobin-related protein	11.0	Publications
26	IGFBP6	insulin-like growth factor binding protein 6	11.0	Publications
27	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
28	VEGFB	vascular endothelial growth factor B	11.0	Publications
29	AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	11.0	Publications
30	BTC	betacellulin	11.0	Publications
31	CYR61	cysteine-rich, angiogenic inducer, 61	11.0	Publications
32	EPHB4	EPH receptor B4	11.0	Publications
33	HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	11.0
34	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
35	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
36	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Publications
37	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	11.0	Publications
38	SHBG	sex hormone-binding globulin	11.0	Publications
39	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications
40	ANGPT2	angiopoietin 2	11.0	Publications
41	AREG	amphiregulin	11.0	Publications
42	BAD	BCL2-associated agonist of cell death	11.0	Publications, Pathways & Interactions
43	CDH3	cadherin 3, type 1, P-cadherin (placental)	11.0	Publications
44	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	11.0	Publications
45	CKB	creatine kinase, brain	11.0	Publications
46	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
47	CTNND1	catenin (cadherin-associated protein), delta 1	11.0	Publications
48	DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	11.0	Publications
49	HPSE	heparanase	11.0	Publications
50	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications

Pathways related to endometrial cancer according to GeneDecks:

(show top 50)    (show all 433)

id	Pathway	Score	Top Affiliating Genes
1	Development_IGF-1 receptor signaling41	12.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
2	P2Y Receptor Signaling36	12.5	PIK3R3, PIK3R2, PIK3R1, BRAF, VEGFB, VEGFC
3	Nanog in Mammalian ESC Pluripotency36	12.5	KITLG, BTC, BRAF, VEGFB, VEGFC, BMP6
4	Adipocytokines & Insulin Signaling37	12.2	PIK3CB, PIK3CD, PIK3R1, PIK3CG, BRAF, LEP
5	p53 Mediated Apoptosis36	12.1	PIK3R3, PIK3R2, PIK3R1, KITLG, BTC, VEGFB
6	p53 signaling pathway20	12.0	SFN, SERPINB5, SERPINE1, CHEK2, BAX, ATR
7	Neurotrophin signaling pathway20	12.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R5
8	Signaling in Gap Junctions36	11.9	PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, GRB2
9	MAPK Signaling36	11.9	PIK3R3, PIK3R2, PIK3R1, KITLG, BTC, BRAF
10	Angiogenesis3	11.8	SERPINB5, VEGFB, VEGFC, KDR, ITGB1, ITGB3
11	Transcription Receptor-mediated HIF regulation10	11.8	PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1, IRS1
12	Immune response IL-2 activation and signaling pathway10	11.7	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, MYC
13	Development Angiopoietin - Tie2 signaling10	11.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14	IL-2 Signaling Pathways37	11.6	PIK3CB, PIK3CD, PIK3R1, PIK3CG, BRAF, RAF1
15	FGF Pathway36	11.6	PIK3R3, PIK3R2, PIK3R1, RAF1, FGF1, FGF2
16	Development PDGF signaling via MAPK cascades10	11.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
17	Development_PDGF signaling via MAPK cascades41	11.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
18	Rho Family GTPases36	11.6	PIK3R3, PIK3R2, PIK3R1, KITLG, BTC, VIM
19	Development_ERBB-family signaling41	11.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
20	Phospholipase-C Pathway36	11.5	KITLG, BTC, VEGFB, VEGFC, BMP6, RAF1
21	Development_VEGF signaling and activation41	11.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
22	Development ERBB-family signaling10	11.5	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, BTC
23	Development VEGF signaling via VEGFR2 - generic cascades10	11.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
24	Apoptosis and survival_BAD phosphorylation41	11.4	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1
25	Translation_Non-genomic (rapid) action of Androgen Receptor41	11.4	PIK3CA, PIK3R1, RAF1, MTOR, FOXO3, IRS1
26	Apoptosis and survival NGF signaling pathway10	11.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
27	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	11.4	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
28	Immune response_BCR pathway41	11.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
29	Immune response_IL-4 signaling pathway41	11.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
30	Development A2A receptor signaling10	11.3	PIK3CB, PIK3CD, PIK3CA, BRAF, BAD, MAP2K2
31	Immune response IL-4 signaling pathway10	11.2	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1
32	Signaling Involved in Cardiac Hypertrophy36	11.1	PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, LIF
33	IL-3 Pathway36	11.0	PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, BAD
34	Jak-STAT signaling pathway20	11.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
35	Immune response_IFN gamma signaling pathway41	11.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
36	Cell cycle_Regulation of G1/S transition (part 2)41	11.0	RB1, RBL2, RBL1, JUN, CDK6, CDK2
37	IL-2 Pathway36	11.0	PIK3R3, PIK3R2, PIK3R1, MYC, RAF1, JUN
38	Development_Endothelin-1/EDNRA signaling41	10.9	GRB2, MAPK14, MAP3K1, CCND1, HRAS, CTNNB1
39	Pathway_PA16598005034	10.9	BRAF, MYC, RAF1, KDR, JUN, FLT1
40	FLT3 Signaling36	10.9	PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, BCL2
41	Hepatitis C20	10.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
42	CNTF Signaling36	10.8	PIK3R3, PIK3R2, PIK3R1, RAF1, JAK2, GRB2
43	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.6	RAF1, LEPR, JAK2, GRB2, TIMP1, SOCS3
44	CCKBR-Gastrin Stimulated Signaling36	10.6	RAF1, JUN, FOS, GRB2, MAPK8, MAP2K2
45	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.5	LEP, LEPR, JAK2, GRB2, MAPK3, MAP2K1
46	Apoptosis Signaling Pathways37	10.3	SFN, BIRC2, BIRC5, BCL2, BAD, BAX
47	Development_TGF-beta receptor signaling41	10.0	SERPINE1, RAF1, CDKN1A, MAP2K2, MAPK3, MAPK14
48	TNF-Induced Apoptosis Implicating Sphingolipids36	9.8	RAF1, BAD, BAX, MAPK8, MAP2K2, MAP2K4
49	Toll-like receptor signaling pathway20	9.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
50	STAT3 Pathway36	9.3	BRAF, MYC, BMP6, BMPR1A, RAF1, LIF

Compounds related to endometrial cancer according to GeneDecks:

(show top 50)    (show all 441)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	25.4	PIK3CB, PIK3R1, NCOA1, NCOA3, PCBD1, PCNA
2	progesterone32 42 9 18 9	26.1	PIK3CA, PIK3R1, NCOA1, NCOA3, SFPQ, SFRP4
3	lipid32	17.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCOA1
4	doxorubicin32 34 9 9	18.4	PIK3CA, PIK3CG, KITLG, SETD2, VIM, BRCA1
5	cisplatin32 34 9 9	18.1	PIK3CA, KITLG, PCNA, RB1, SETD2, SERPINB5
6	wortmannin32 42	15.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RET
7	ribonucleic acid32	14.1	RET, KITLG, SERPINA6, SERPINB2, VEGFC, MYC
8	vitamin d32	14.0	NCOA1, NCOA3, SERPINE1, VIM, BMP6, ZEB1
9	5-aza-2deoxycytidine32	13.5	KITLG, PCNA, SERPINB5, VIM, BRCA1, BNIP3
10	quercetin32 42 9 18 9	17.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
11	adenine32 9 18 9	16.2	RET, SETD2, BRAF, BRCA1, RAD51, SCGB1A1
12	cyclosporin a32 42	13.9	PIK3CA, PIK3CG, KITLG, SERPINB2, MYC, RAF1
13	fulvestrant32 34 9 9	15.8	PIK3CG, PCNA, AR, MAPK1, IGFBP3, ESR1
14	glycerol32 9 18 9	15.6	PCNA, BRCA1, PAEP, LEP, CDK2, CD36
15	threonine32	12.6	RET, RBL2, BMPR1A, RAF1, PAX8, PAK3
16	erlotinib32 34 9 9	15.5	PIK3CA, VEGFA, BIRC5, KDR, MTOR, CDKN1B
17	benzo(a)pyrene32	12.2	RB1, BRCA1, UGT1A, UGT1A1, UGT2B7, XRCC1
18	gefitinib32 34 9 9	15.1	PIK3CA, PIK3CG, VIM, VEGFA, RAD51, BIRC5
19	biotin32 9 18 9	14.9	KITLG, PCNA, RB1, VIM, B2M, MSH2
20	celecoxib32 42 34 9 18 9	16.9	PIK3R1, PIK3CG, PCNA, VEGFA, BIRC5, PARP1
21	histamine32 18	12.9	PIK3CA, KITLG, PCNA, VIM, BMP6, RAF1
22	azathioprine32 34 9 9	14.8	PCNA, VIM, RASSF1, LIF, MTHFR, S100A6
23	oxaliplatin32 34 9 9	14.7	BRCA1, VEGFA, BIRC5, UGT1A1, MTHFR, XRCC1
24	flutamide32 9 9	13.7	LHCGR, AR, FGF7, GNRH1, ESR1, CYP1A1
25	sulforaphane32	11.6	PIK3CG, RB1, PARP1, UGT1A, UGT1A1, JUN
26	glutamine32	11.5	PIK3CG, NCOA1, NCOA3, PCNA, VIM, BRCA1
27	gf 109203x32 42	12.5	PIK3CB, PIK3CG, KITLG, VEGFA, RAF1, JUN
28	methylcellulose32	11.4	KITLG, LIF, CDH1, FGF2, IL1A, IL6
29	carboplatin32 34 9 9	14.3	KITLG, RB1, BRCA1, VEGFA, LIF, PARP1
30	metformin32 34 9 9	14.3	PIK3CA, PIK3CG, SERPINE1, LEP, MTHFR, IRS1
31	latex32	11.3	KITLG, LIF, SCGB1A1, CHEK2, CDH2, CDC25C
32	methylmethanesulfonate32	11.2	PCNA, BRCA1, BRCA2, RAD51, PARP1, XRCC1
33	sorafenib32 9 9	13.2	RET, BRAF, VEGFA, RAF1, KDR, MTOR
34	sb 20358032 42	12.1	RB1, SETD2, VIM, BRAF, VEGFA, BNIP3
35	tetracycline32 9 9	13.0	RB1, SCGB1A1, CDK2, CDKN2A, MMP1, MMP2
36	nifedipine32 9 9	12.9	PIK3CG, SERPINE1, BMP6, LEP, UGT1A, B2M
37	aphidicolin32	10.7	PCNA, RB1, BRCA1, MYC, RAD51, CHEK2
38	hydroxyurea32 9 9	12.7	KITLG, PCNA, BRCA1, BRCA2, MYC, RAD51
39	lapatinib32 34 9 9	13.7	BIRC5, AR, MCL1, CCND1, IGF1R, ESR1
40	butyrate32	10.6	NCOA1, NCOA3, RET, KITLG, PCNA, RB1
41	mithramycin32	10.5	PIK3CG, MYC, BIRC5, CFLAR, JUN, CDKN1A
42	prostaglandin32	10.3	KITLG, VIM, VEGFC, LIF, PAEP, CDK4
43	herbimycin a32 42	11.2	PIK3CG, RET, KITLG, MYC, BMP6, RAF1
44	thalidomide32 42 9 9	13.1	VEGFA, BIRC2, BIRC5, KDR, B2M, CD36
45	cd 43732	10.1	MYC, PARP1, BCL2, BAX, JUN, CDKN1A
46	tacrolimus32 34 9 9	12.9	PIK3CA, PCNA, SERPINE1, MYC, BMP6, RAF1
47	atorvastatin32 34 9 18 9	13.8	VEGFA, BMP6, CHKA, MMP1, MMP2, MMP9
48	methotrexate32 34 42 9 9	13.7	KITLG, PCNA, RB1, SERPINE1, VIM, BRCA1
49	simvastatin32 34 42 9 18 9	14.1	KITLG, SERPINE1, VEGFA, BMP6, KDR, CHKA
50	rantes32	8.8	KITLG, BMP6, LIF, PAEP, JUN, CD44

Cellular components related to endometrial cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	20.8	PIK3CB, PIK3R5, NDC80, NCOA3, PDCD4, SFN
2	cytoplasm	GO:005737	17.9	PIK3R5, PIK3CG, NCOA3, PDCD4, KITLG, SFN
3	plasma membrane	GO:005886	17.1	PIK3CD, PIK3R1, PIK3CG, KITLG, BTC, SERPINB2
4	cytosol	GO:005829	15.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	nucleoplasm	GO:005654	13.7	NCOA1, NCOA3, SFPQ, PCNA, RB1, RBL2
6	extracellular region	GO:005576	13.6	KITLG, BTC, SERPINB2, SERPINA1, SERPINE1, VEGFA
7	extracellular space	GO:005615	12.6	KITLG, SFN, SFRP4, BTC, SERPINB5, SERPINB2
8	integral to plasma membrane	GO:005887	12.5	RET, KIAA1324, LPAR2, RAMP2, CLDN4, CLDN3
9	cell surface	GO:009986	11.0	SFRP4, VEGFA, LPAR2, RAMP2, AXL, CD36
10	membrane raft	GO:045121	10.1	BCL10, JAK2, CD36, ITGA1, ITGB1, GSK3B

Biological processes related to endometrial cancer according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	14.7	PIK3CB, PIK3CD, RET, KITLG, SFN, VEGFC
2	angiogenesis	GO:001525	13.1	PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
3	positive regulation of cell proliferation	GO:008284	13.1	BTC, VEGFA, VEGFC, MYC, LIF, BIRC5
4	insulin receptor signaling pathway	GO:008286	12.9	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, RAF1
5	negative regulation of cell proliferation	GO:008285	12.4	SFN, SFRP4, RAF1, LIF, PAWR, ZEB1
6	fibroblast growth factor receptor signaling pathway	GO:008543	12.3	PIK3CA, PIK3R1, BRAF, RAF1, BAD, MTOR
7	response to organic cyclic compound	GO:014070	12.2	SERPINA1, LEF1, UGT1A1, MSH2, JUN, JUNB
8	negative regulation of apoptotic process	GO:043066	12.1	PIK3CG, BTC, SERPINE1, BRAF, VEGFA, MYC
9	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.9	MYC, BMI1, PAWR, PARP1, ZEB1, SCGB1A1
10	apoptotic process	GO:006915	11.9	PDCD4, SFN, VIM, BRCA1, BNIP3, RAF1
11	cell proliferation	GO:008283	11.8	KITLG, SFN, PCNA, RAF1, ZEB1, SCRIB
12	transcription initiation from RNA polymerase II promoter	GO:006367	11.8	RBL1, SERPINE1, MYC, PARP1, JUNB, AR
13	phosphatidylinositol-mediated signaling	GO:048015	11.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, NDC80, PCNA
14	response to estradiol stimulus	GO:032355	11.8	NCOA1, SFRP4, SERPINA1, BRCA2, MMP9, INSR
15	epidermal growth factor receptor signaling pathway	GO:007173	11.8	PIK3CA, PIK3R1, RAF1, BAD, MTOR, CDKN1B
16	positive regulation of angiogenesis	GO:045766	11.7	SERPINE1, VEGFA, RAMP2, KDR, MTDH, MMP9
17	induction of apoptosis by intracellular signals	GO:008629	11.7	BNIP3, MYC, BCL2, BAD, BAX, MSH6
18	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.6	NCOA1, NCOA3, RB1, RBL1, SERPINE1, BRCA1
19	positive regulation of transcription, DNA-dependent	GO:045893	11.6	NCOA1, NCOA3, RET, RB1, BRCA1, BRCA2
20	positive regulation of fibroblast proliferation	GO:048146	11.6	MYC, BMI1, S100A6, JUN, CDK6, CDKN1A
21	blood coagulation	GO:007596	11.6	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
22	positive regulation of cell division	GO:051781	11.5	BTC, VEGFA, VEGFB, VEGFC, FIGF, FGF1
23	nerve growth factor receptor signaling pathway	GO:048011	11.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, BRAF, RAF1
24	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.5	KITLG, VEGFA, VEGFB, LIF, MTOR, JAK2
25	positive regulation of cell migration	GO:030335	11.5	RET, VEGFA, KDR, LEF1, JAK2, CDH13
26	positive regulation of MAPK cascade	GO:043410	11.4	LPAR2, LIF, KDR, LEP, CD36, CDH2
27	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.3	BRAF, VEGFB, KDR, CD44, FGF2, FGF4
28	cell cycle arrest	GO:007050	11.2	RB1, VASH1, MYC, RASSF1, MSH2, ATM
29	Ras protein signal transduction	GO:007265	11.2	RB1, RAF1, RASSF1, CDKN1A, CDK2, CDKN2A
30	response to lipopolysaccharide	GO:032496	11.1	SERPINA1, UGT1A1, JUN, JAK2, MMP9, IL1A
31	positive regulation of epithelial cell proliferation	GO:050679	11.1	VEGFC, MYC, BMP6, BMPR1A, BAD, FGF1
32	anti-apoptosis	GO:006916	11.0	PIK3CA, SERPINB2, BRAF, VEGFB, BNIP3, BIRC2
33	aging	GO:007568	10.9	JUN, GRB2, FAS, IGFBP2, CASP7, ERCC2
34	protein autophosphorylation	GO:046777	10.9	KDR, CHEK2, MTOR, ATR, ATM, JAK2
35	positive regulation of protein phosphorylation	GO:001934	10.9	VEGFA, MTOR, AXIN1, AXIN2, ITGB3, INSR
36	positive regulation of protein kinase B signaling cascade	GO:051897	10.8	PIK3R5, PIK3CG, VEGFB, MTDH, MTOR, AXL
37	positive regulation of apoptotic process	GO:043065	10.8	NCOA1, SFRP4, PAWR, SCRIB, BAD, BAX
38	organ regeneration	GO:031100	10.7	LIF, LEF1, UGT1A1, CDKN1A, CDK1, ANGPT2
39	response to drug	GO:042493	10.6	VEGFC, MYC, BCL2, LHCGR, UGT1A1, BAG1
40	female pregnancy	GO:007565	10.5	CLDN4, BCL2, SCGB1A1, LEP, FLT1, IGFBP2
41	toll-like receptor 2 signaling pathway	GO:034134	10.3	JUN, CDK1, FOS, MAPK8, MAP2K2, MAP2K4
42	platelet activation	GO:030168	10.2	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
43	toll-like receptor signaling pathway	GO:002224	10.2	BCL10, JUN, CDK1, FOS, MAPK8, MAP2K2
44	response to hypoxia	GO:001666	10.2	SERPINA1, VEGFA, BNIP3, RAF1, CLDN3, BCL2
45	activation of MAPK activity	GO:000187	9.8	PIK3CB, LPAR2, PAK3, CDK1, ITGA1, INSR
46	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.7	MYC, BAD, BAX, JAK2, CDKN1B, CDKN2A
47	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.7	PIK3CA, BRAF, VEGFA, RAF1, LIF, BCL2
48	inflammatory response	GO:006954	9.4	PIK3CD, PIK3CG, BMP6, AXL, FOS, IL1A
49	induction of apoptosis	GO:006917	9.4	BNIP3, PAWR, BCL10, BAD, BAX, CDKN1B
50	MAPK cascade	GO:000165	9.4	RET, MYC, RAF1, PAK3, CDK1, FGFR3

Molecular functions related to endometrial cancer according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	24.8	STAT3, TIMP1, TLR4, TLR2, TOP1, TSG101
2	ATP binding	GO:005524	14.3	PRKCA, DDR1, DICER1, PTK2, TEP1, TP53
3	sequence-specific DNA binding transcription factor activity	GO:003700	13.5	HNF1B, ESR1, ESR2, TP53, TP73, PTTG1
4	sequence-specific DNA binding	GO:043565	12.8	PGR, EPAS1, NR1I2, RXRB, NR1H2, PPARG
5	enzyme binding	GO:019899	12.6	NOD2, HYAL2, CCND1, MDM2, AR, MSH3
6	protein homodimerization activity	GO:042803	12.4	PON1, CSF1R, CSF1, SOD1, TGFB1, TWIST1
7	transcription factor binding	GO:008134	12.2	ZEB1, BCL2, BCL10, PARP1, MYC, RBL1
8	protein kinase binding	GO:019901	12.0	PDPK1, NOD2, SMAD3, PTPRC, PTK2, PTEN
9	growth factor activity	GO:008083	11.8	TFF1, TGFB1, TGFA, TYMP, HBEGF, EGF
10	receptor binding	GO:005102	11.7	NRG1, CRAT, CRH, LTA, HILPDA, TDGF1
11	steroid binding	GO:005496	11.6	UGT1A1, GPER, ESR1, ESR2, ESRRA, ESRRB
12	protein phosphatase binding	GO:019903	11.5	EGFR, CDKN1B, PIK3R1, CTNNB1, ERBB2, GRB2
13	protein heterodimerization activity	GO:046982	11.4	EPAS1, TP53, ERBB2, ERBB3, HNF1B, MCL1
14	double-stranded DNA binding	GO:003690	11.3	CTNNB1, NR5A1, MYC, NR3C1, SMAD3, EGFR
15	beta-catenin binding	GO:008013	11.2	MET, TCF7L2, SMAD7, SMAD3, CTNNA1, ESR1
16	transmembrane receptor protein tyrosine kinase activity	GO:004714	11.0	EPHB4, TYRO3, ERBB4, RET, EPHA2, KDR
17	transcription regulatory region DNA binding	GO:044212	10.7	ERBB4, HNF1B, ETV5, AR, FOXC1, FOS
18	identical protein binding	GO:042802	10.7	PCBD1, VIM, BNIP3, RAD51, TP73, TNF
19	protein tyrosine kinase activity	GO:004713	10.4	SHC1, IGF1R, ERBB3, ERBB4, ERBB2, TYRO3
20	cytokine activity	GO:005125	9.4	TNF, TNFSF10, SPP1, IL1A, IFNB1, IFNA2