MCID: END042
MIFTS: 69

Endometrial Carcinoma malady

Cancer category

Summaries for Endometrial Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Endometrial cancer is any of several types of malignancies that arise from the endometrium, or lining,... more...

MalaCards: Endometrial Carcinoma, also known as endometrial cancer, is related to adenocarcinoma and papillary carcinoma. An important gene associated with Endometrial Carcinoma is MSH3 (mutS homolog 3), and among its related pathways are Pathways in cancer and Endometrial cancer. The compounds progesterone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the tissue lining the uterus, and related mouse phenotypes are cellular and tumorigenesis.

Disease Ontology:8 A endometrial cancer that is located in the tissue lining the uterus.

Description from OMIM:47 608089

Aliases & Classifications for Endometrial Carcinoma

Sources:
8Disease Ontology, 47OMIM, 45Novoseek, 61UMLS, 9diseasecard, 43NIH Rare Diseases, 22GTR, 10DISEASES, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

endometrial carcinoma 8 47 45 61
endometrial cancer 9 43 22 47 10 45
endometrioid carcinoma of female reproductive system 8
carcinoma of the endometrium 8
carcinoma of endometrium 8
carcinoma, endometrioid 61
endometrioid carcinoma 8
carcinoma endometrioid 45


External Ids:

Disease Ontology8 DOID:2871
MeSH35 D018269
OMIM47 608089
NCIt40 C3769
ICD1025 C54.1

Related Diseases for Endometrial Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Endometrial Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.8IFI27, CTNNB1, ARSH, PIK3CA, MLH1, MKI67
2papillary carcinoma30.8ESR1, PGR, CDH1, MKI67, IFI27
3endometrial carcinoma, somatic30.7CDH1, PTEN
4colorectal cancer30.3IFI27, CTNNB1, PTEN, MSH3, KRAS, CDH1
5wilms tumor30.3CTNNB1
6infertility30.2ESR1, HOXA10
7squamous cell carcinoma30.2MKI67, CDH1, MMP26
8myoma30.2PGR, ESR1
9turcot syndrome30.0CTNNB1, MLH1, PTEN
10cystadenoma30.0KRAS
11adenoma30.0MKI67, CDKN2A, CDH1, KRAS, TDGF1P3, MLH1
12thyroid cancer30.0PTEN, CDH1, PIK3CA, IFI27
13oral cancer30.0IFI27, CDKN2A, CDH1
14transitional cell carcinoma30.0IFI27, MLH1, MKI67, CDH1
15tuberous sclerosis30.0PTEN, PIK3CA, IFI27
16familial colorectal cancer30.0MLH1, CDKN2A, PTEN
17inflammatory breast carcinoma30.0ESR1, PGR, CDH1
18adenocarcinoma in situ30.0CDKN2A
19uterine sarcoma30.0ESR1
20progesterone resistance30.0PGR, ESR1
21prolactinoma30.0ESR1
22malignant mixed mullerian tumor30.0PGR, ESR1
23colorectal cancer, somatic30.0PIK3CA, MLH3
24endometrial stromal sarcoma30.0PGR, ESR1
25small cell carcinoma10.7
26neuroendocrine carcinoma10.6
27vascular cancer10.5
28verrucous carcinoma10.5
29large cell carcinoma10.5
30hypoxia10.4
31peritoneal carcinoma10.4
32adenomyosis10.4
33squamous cell papilloma10.3
34ovarian brenner tumor10.3
35ovarian endometriosis10.3
36wolffian tumor10.3
37uterine inversion10.2
38bone carcinoma10.2
39thrombocytosis10.2
40atypical polypoid adenomyoma10.2
41membranous glomerulonephritis10.2
42papillary squamous carcinoma10.2
43cushing's syndrome10.2
44congenital adrenal hyperplasia10.2
45cervix small cell carcinoma10.2
46papillary transitional carcinoma10.2
47multicentric reticulohistiocytosis10.2
48hypercalcemia10.2
49adrenal carcinoma10.2
50anal squamous cell carcinoma10.2

Graphical network of the top 20 diseases related to Endometrial Carcinoma:



Diseases related to endometrial carcinoma

Clinical Features for Endometrial Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608089

Drugs & Therapeutics for Endometrial Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endometrial Carcinoma

Drug clinical trials:

Search ClinicalTrials for Endometrial Carcinoma

Search NIH Clinical Center for Endometrial Carcinoma

Search CenterWatch for Endometrial Carcinoma

Genetic Tests for Endometrial Carcinoma

Sources:
22GTR
See all sources

Genetic tests related to Endometrial Carcinoma:

id Genetic test Affiliating Genes
1 Endometrial Carcinoma22

Anatomical Context for Endometrial Carcinoma

Sources:
14FMA
See all sources

FMA organs/tissues related to Endometrial Carcinoma:

14
The tissue lining the uterus

Animal Models for Endometrial Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Endometrial Carcinoma

Sources:
51PubMed
See all sources

Articles related to Endometrial Carcinoma:

(show top 50)    (show all 1347)
idTitleAuthorsYear
1
The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. (24285342)
2014
2
Reproducibility of histological cell type in high-grade endometrial carcinoma. (23807777)
2013
3
Expression of p53 in imprint smears of endometrial carcinoma. (24167025)
2013
4
DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells. (23376256)
2013
5
ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. (23743934)
2013
6
ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas. (22266854)
2012
7
Merkel cell carcinoma in pelvic lymph nodes after surgical staging for endometrial cancer: A case report and review of the literature. (22580079)
2012
8
Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway. (22459351)
2012
9
Predictive and prognostic factors in definition of risk groups in endometrial carcinoma. (23209924)
2012
10
The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma. (22626766)
2012
11
Stem cells in human endometrium and endometrial carcinoma. (21623195)
2011
12
Kit gene in endometrial carcinoma: an immunohistochemical and mutational analysis. (21270602)
2011
13
The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. (20133454)
2010
14
Expression of metabolically targeted biomarkers in endometrial carcinoma. (19878980)
2010
15
Preoperative assessment of myometrial and cervical invasion in endometrial carcinoma: comparison of multi-section dynamic MR imaging using a three dimensional FLASH technique and T2-weighted MR imaging. (20598007)
2010
16
Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. (20178884)
2010
17
Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin. (19583808)
2010
18
The number of metastatic sites for stage IIIA endometrial carcinoma, endometrioid cell type, is a strong negative prognostic factor. (20060158)
2010
19
Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma. (19424619)
2009
20
Magnetic resonance imaging for assessment of deep endometrial invasion for patients with endometrial carcinoma. (19780740)
2009
21
Concurrent endometrial carcinoma in patients with a curettage diagnosis of endometrial hyperplasia. (19515631)
2009
22
E-cadherin expression in endometrial malignancies: comparison between endometrioid and non-endometrioid carcinomas. (19215686)
2009
23
Expression and function of cyclooxygenase-2 in endometrial carcinoma]. (20019776)
2009
24
Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells. (17590421)
2007
25
Expression of HPV, steroid receptors (ERalpha, ERbeta, PR-A and PR-B) and inhibin/activin subunits (alpha, betaA and betaB) in adenosquamous endometrial carcinoma. (17649814)
2007
26
P16(INK4a) overexpression independent of Human Papilloma Virus (HPV) infection in rare subtypes of endometrial carcinomas. (17498885)
2007
27
PTEN sensitizes epidermal growth factor-mediated proliferation in endometrial carcinoma cells. (16525671)
2006
28
High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer. (15904949)
2005
29
Expression of estrogen receptor-related receptor isoforms in endometrial carcinoma tissues and its clinical significance]. (16324250)
2005
30
Expression of inhibitory natural killer receptors on tumor-infiltrating CD8+ T lymphocyte lineage in human endometrial carcinoma. (16343184)
2005
31
Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? (15837969)
2005
32
Overexpression of estrogen receptor-alpha gene suppresses gap junctional intercellular communication in endometrial carcinoma cells. (14762440)
2004
33
VEGF expression and its reguration by p53 gene transfection in endometrial carcinoma cells. (12971625)
2003
34
Estrogen sulfotransferase and sulfatase: Roles in the regulation of estrogen activity in human uterine endometrial carcinomas. (14556660)
2003
35
Study on the treatment of high dose mifepristone and progesterone in endometrial carcinoma]. (14680611)
2003
36
Vascular endothelial growth factor and plasminogen activators in endometrial carcinoma and hyperplasia]. (14976916)
2003
37
Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. (14559803)
2003
38
Apoptosis and apoptosis-related factors Bcl-2, Bax, tumor necrosis factor-alpha, and NF-kappaB in human endometrial hyperplasia and carcinoma. (12237915)
2002
39
Papillary serous carcinoma of the peritoneum coexisting with or after endometrial carcinoma. (11812082)
2002
40
Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. (11213834)
2001
41
Immunohistochemical study on VEGF expression in endometrial carcinoma--comparison with p53 expression, angiogenesis, and tumor histologic grade. (11710596)
2001
42
Epidermal growth factor receptors and their ligands in endometrial carcinoma: correlation with clinico-morphologic factors and steroid receptors]. (10853417)
2000
43
Loss of expression of the gene deleted in colon carcinoma (DCC) is closely related to histologic differentiation and lymph node metastasis in endometrial carcinoma. (10023715)
1999
44
Estrogenicity of bisphenol A in a human endometrial carcinoma cell line. (10411312)
1999
45
p53 staining as a prognostic indicator in endometrial carcinoma. (10376438)
1999
46
Distinctive p53 and mdm2 immunohistochemical expression profiles suggest different pathogenetic pathways in poorly differentiated endometrial carcinoma. (9553809)
1998
47
Correlations between p21 expression and clinicopathological findings, p53 gene and protein alterations, and survival in patients with endometrial carcinoma. (9422988)
1997
48
Presence of gonadotropin-releasing hormone receptor and its messenger ribonucleic acid in endometrial carcinoma and endometrium. (7959256)
1994
49
Aggressive stage I grade 1 endometrial carcinoma. (1643610)
1992
50
Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Part I: Clinical and histologic correlations. (1697729)
1990

Genetic Variations for Endometrial Carcinoma

Expression for genes affiliated with Endometrial Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endometrial Carcinoma

Search GEO for disease gene expression data for Endometrial Carcinoma.

Pathways for genes affiliated with Endometrial Carcinoma

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN
See all sources

Pathways related to Endometrial Carcinoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.5CTNNB1, PIK3CA, MLH1, CDKN2A, CDH1, KRAS
2
Hide members
11.4PTEN, CTNNB1, PIK3CA, MLH1, CDH1, KRAS
3
Hide members
11.2CTNNB1, PIK3CA, CDH1, KRAS, PTEN, ESR1
411.1CTNNB1, CDH1, KRAS, PTEN, ESR1
5
Hide members
11.1PIK3CA, PGR, KRAS, PTEN, ESR1
611.1ESR1, PTEN, KRAS, PIK3CA, CTNNB1
7
Development Endothelin-1/EDNRA signaling
Hide members
11.1CTNNB1, PIK3CA, KRAS, PTEN, ESR1
811.0ESR1, KRAS, PIK3CA, CTNNB1
911.0PTEN, KRAS, CDKN2A, PIK3CA
1011.0KRAS, CDKN2A, PIK3CA, CTNNB1
11
Hide members
10.9MLH1, MLH3, MSH3
1210.9CTNNB1, CDH1, KRAS
13
Transcription Androgen Receptor nuclear signaling
Hide members
10.9CTNNB1, PIK3CA, PTEN
1410.9CTNNB1, PIK3CA, CDH1
15
Hide members
10.9CDH1, PIK3CA, CTNNB1
1610.9CDH1, PIK3CA, CTNNB1
1710.9CTNNB1, PIK3CA, CDH1
1810.9CTNNB1, CDKN2A, PTEN
19
Hide members
10.9ESR1, ESRRA, PGR
20
Hide members
10.9KRAS, CDKN2A, PIK3CA
2110.7CDH1, CTNNB1
2210.7CTNNB1, CDH1
2310.6MSH3
24
Hide members
10.6KRAS

Compounds for genes affiliated with Endometrial Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Endometrial Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2416.8MKI67, CDKN2A, CDH1, HOXA10, PGR, PTEN
2retinoic acid45 2413.7MKI67, CDKN2A, CDH1, MMP26, KRAS, PTEN
3testosterone45 60 11 2415.4PIK3CA, ESRRA, ESR1, PTEN, ARSH, PGR
4vegf4512.4MLH1, PIK3CA, CTNNB1, IFI27, MKI67, ESR1
5doxorubicin45 50 1114.3PIK3CA, ESR1, PTEN, MSH3, PGR, CDH1
6tyrosine4512.2PTEN, KRAS, ANG, HOXA10, CDH1, MKI67
7paclitaxel45 50 1114.2IFI27, CTNNB1, PIK3CA, PTEN, ESR1, MLH1
85fluorouracil4512.2CDKN2A, CDH1, PGR, KRAS, PTEN, ESR1
9tamoxifen45 50 29 1115.2ESRRA, PIK3CA, CTNNB1, MKI67, CDH1, PTEN
10paraffin4512.2ESR1, KRAS, PGR, CDH1, CDKN2A, MKI67
11cisplatin45 50 60 1115.2MSH3, CDH1, CDKN2A, IFI27, MKI67, MLH1
12genistein45 29 60 2 11 2417.0PTEN, ESRRA, ESR1, PGR, CDH1, IFI27
13arginine4512.0IFI27, PTEN, ARSH, CDH1, PIK3CA, MLH1
14steroid4511.9IFI27, ARSH, PIK3CA, MKI67, CDKN2A, HOXA10
15crcs4511.8CDH1, KRAS, PTEN, PIK3CA, CTNNB1, MLH1
16gefitinib45 50 1113.8KRAS, IFI27, CTNNB1, ESR1, PTEN, PIK3CA
175-aza-2deoxycytidine4511.8PTEN, ESR1, PGR, CDH1, CDKN2A, MLH1
18agar4511.8CDKN2A, PIK3CA, CDH1, PGR, PTEN, TDGF1P3
19fatty acid4511.7PTEN, MLH1, CTNNB1, IFI27, KRAS, ESRRA
20ly2940024511.7PTEN, PIK3CA, KRAS, CDH1, CTNNB1, IFI27
21trastuzumab45 50 1113.6IFI27, PTEN, PGR, PIK3CA, CTNNB1, ESR1
22estradiol45 11 2413.6ARSH, PTEN, MMP26, HOXA10, MKI67, PGR
23p0024511.6IFI27, CTNNB1, CDH1, KRAS, MKI67, MLH1
24mg 13245 6012.6IFI27, CTNNB1, CDH1, PTEN, ESR1, CDKN2A
25indole-3-carbinol4511.5IFI27, CTNNB1, CDH1, PTEN, ESR1
26diethylstilbestrol45 29 1113.5PGR, ESRRA, ESR1, PTEN, HOXA10
27vitamin d4511.5PTEN, ESR1, IFI27, CTNNB1, CDH1, KRAS
28irinotecan45 50 1113.5KRAS, CDH1, CDKN2A, MLH1, MKI67
29thymidylate4511.4CDH1, IFI27, MLH1, MKI67, CDKN2A
30docetaxel45 50 60 1114.4PIK3CA, CDKN2A, CDH1, ESR1, PGR
31sodium bisulfite4511.4CDKN2A, CDH1, MLH1, CTNNB1
32rapamycin4511.3PTEN, KRAS, CDH1, PIK3CA, CTNNB1, IFI27
33chi 24511.3MLH1, IFI27, MKI67, CDH1
34danazol45 11 2413.3ARSH, CDH1, PGR, ESR1
35o6-methylguanine4511.3MLH1, KRAS, CDKN2A, CDH1
36p000014511.3MLH1, CDH1, CDKN2A, MKI67
37steroidal4511.3PGR, IFI27, ESR1, ARSH
38bromodeoxyuridine4511.3CTNNB1, MLH1, MKI67, PIK3CA, IFI27
39sulindac45 1112.2IFI27, CTNNB1, MLH1, CDH1
40erlotinib45 50 1113.2CDH1, PIK3CA, KRAS, PTEN
41oxygen45 2412.2KRAS, IFI27, CDKN2A, MKI67, PTEN, ARSH
42estrogen4511.2HOXA10, ARSH
43quercetin45 60 11 2414.1PTEN, PIK3CA, CTNNB1, IFI27, ARSH
44folate4511.1MLH1, CDKN2A, CDH1, PGR, MKI67
4517beta-hydroxysteroid4511.0ARSH, MKI67, PGR, ESR1
46dihydrotestosterone45 29 11 2414.0ESR1, PGR, ARSH
47resveratrol45 60 11 2413.9PGR
48butyrate4510.9ARSH
49progestins4510.9ARSH, MKI67, ESR1, PGR
50cycloheximide4510.8HOXA10

GO Terms for genes affiliated with Endometrial Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Endometrial Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.7CTNNB1, MLH1, MLH3, ANG, MKI67, CDKN2A
2internal side of plasma membraneGO:00989810.9PTEN, CDH1, CTNNB1
3chiasmaGO:00571210.9MLH3, MLH1
4MutLbeta complexGO:03239010.8MLH3, MLH1
5mismatch repair complexGO:03230010.7MLH1, MLH3
6Schmidt-Lanterman incisureGO:04322010.7PTEN, CDH1
7catenin complexGO:01634210.6CDH1, CTNNB1

Biological processes related to Endometrial Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.9MSH3, MLH3, MLH1
2reciprocal meiotic recombinationGO:00713110.9MSH3, MLH3, MLH1
3positive regulation of nitric-oxide synthase activityGO:05100010.7ESR1, KRAS
4regulation of protein localization to cell surfaceGO:200000810.6CTNNB1, CDH1
5cellular response to indole-3-methanolGO:07168110.4CTNNB1, CDH1

Molecular functions related to Endometrial Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.6MKI67, KRAS, PGR, HOXA10, CDH1, CDKN2A
2enzyme bindingGO:01989911.3MSH3, PTEN, ESR1, PGR, CTNNB1
3steroid bindingGO:00549611.0PGR, ESRRA, ESR1
4steroid hormone receptor activityGO:00370710.9PGR, ESR1, ESRRA
5guanine/thymine mispair bindingGO:03213710.8MSH3, MLH1
6single-stranded DNA bindingGO:00369710.8MSH3, MLH1, MLH3
7centromeric DNA bindingGO:01923710.7MLH3, MSH3
8mismatched DNA bindingGO:03098310.7MSH3, MLH3
9MutSalpha complex bindingGO:03240710.4MLH3, MLH1

Products for genes affiliated with Endometrial Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endometrial Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet