MCID: END042
MIFTS: 72

Endometrial Carcinoma malady

Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases categories

Summaries for Endometrial Carcinoma

About this section
Sources:
9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Endometrial cancer is cancer that arises from the lining of the uterus, which is known as the... more...

MalaCards: Endometrial Carcinoma, also known as endometrial cancer, is related to adenocarcinoma and endometriosis. An important gene associated with Endometrial Carcinoma is MLH3 (mutL homolog 3), and among its related pathways are Integrated Breast Cancer Pathway and Endometrial cancer. The compounds ici 164384 and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include the tissue lining the uterus, uterus and lymph node, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:9 A endometrial cancer that is located in the tissue lining the uterus.

Description from OMIM:48 608089

Aliases & Classifications for Endometrial Carcinoma

About this section
Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
See all sources

Classifications:



Aliases & Descriptions:

endometrial carcinoma 9 46 63
endometrial cancer 10 44 23 48 11 46
endometrioid carcinoma of female reproductive system 9
carcinoma of the endometrium 9
carcinoma of endometrium 9
carcinoma, endometrioid 63
endometrioid carcinoma 9
carcinoma endometrioid 46


External Ids:

Disease Ontology9 DOID:2871
NCIt41 C3769
MeSH36 D018269
OMIM48 608089
ICD1026 C54.1

Related Diseases for Endometrial Carcinoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Endometrial Carcinoma family:

Endometrial Cancer, Familial

Diseases related to Endometrial Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.8TERC, MLH1, PTEN, SULT1E1, PGR, ESR1
2endometriosis30.8HOXA10, PTEN, PGR, ESR1, UCN
3lynch syndrome30.5MLH3, MLH1
4papillary carcinoma30.5PGR, ESR1, IFI27, CDH1
5colorectal cancer30.4MLH1, PTEN, CEACAM4, IFI27, TDGF1P3, CDH1
6breast cancer30.4HSD17B13, PGR, ESR1, IFI27, HPR, CDH1
7ovarian cancer30.4TERC, MLH1, PTEN, PGR, ESR1, IFI27
8myoma30.4ESR1, PGR
9cervical adenocarcinoma30.4PGR, ESR1, IFI27
10retinoblastoma30.3TERC, ESR1, IFI27, UCN
11infertility30.3ESR1, TERC, HOXA10
12turcot syndrome30.3MLH1, PTEN
13progesterone resistance30.2PGR, ESR1
14malignant mixed mullerian tumor30.2ESR1, PGR
15endometrial stromal sarcoma30.2PGR, ESR1
16transitional cell carcinoma30.1CDH1, IFI27, MLH1, TERC
17colon cancer30.1MLH1, CEACAM4, TDGF1P3, CDH1
18pancreatic cancer30.0CDH1, IFI27, ANG, MLH1, TERC
19melanoma30.0TERC, MLH1, PTEN, MMP26, ANG, IFI27
20small cell carcinoma10.7
21cervicitis10.6
22endotheliitis10.6
23neuroendocrine carcinoma10.5
24verrucous carcinoma10.5
25peritonitis10.5
26vaginitis10.5
27hypoxia10.5
28large cell neuroendocrine carcinoma10.4
29adenomyosis10.4
30ovarian brenner tumor10.3
31lymphoepithelioma-like carcinoma10.3
32obesity10.3
33uterine inversion10.2
34atypical polypoid adenomyoma10.2
35wilms tumor10.2
36endometrial carcinoma, somatic10.2
37ovarian endometrioid neoplasm10.2
38membranous glomerulonephritis10.2
39congenital adrenal hyperplasia10.2
40small cell neuroendocrine carcinoma10.2
41multicentric reticulohistiocytosis10.2
42hypercalcemia10.2
43cushing's syndrome10.2
44glomerulonephritis10.2
45papillary adenocarcinoma10.2
46pelvic inflammatory disease10.2
47prostatitis10.2
48pseudohermaphroditism10.2
49poorly differentiated endocrine carcinoma of the corpus uteri10.2
50thrombocytosis10.2

Graphical network of the top 20 diseases related to Endometrial Carcinoma:



Diseases related to endometrial carcinoma

Symptoms for Endometrial Carcinoma

About this section
Sources:
48OMIM
See all sources


Clinical features from OMIM:

608089

Drugs & Therapeutics for Endometrial Carcinoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endometrial Carcinoma

Drug clinical trials:

Search ClinicalTrials for Endometrial Carcinoma

Search NIH Clinical Center for Endometrial Carcinoma

Search CenterWatch for Endometrial Carcinoma

Genetic Tests for Endometrial Carcinoma

About this section
Sources:
23GTR
See all sources

Genetic tests related to Endometrial Carcinoma:

id Genetic test Affiliating Genes
1 Endometrial Carcinoma23

Anatomical Context for Endometrial Carcinoma

About this section
Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Endometrial Carcinoma:

34
Uterus, Lymph node, Endothelial, Breast, Ovary, Colon, Testes, Cervix, Bone, Testis, Pituitary, Lung, Retina, T cells, Brain

FMA organs/tissues related to Endometrial Carcinoma:

15
The tissue lining the uterus

Animal Models for Endometrial Carcinoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Endometrial Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7TERC, MLH1, PTEN, PGR, ESR1, CDH1
2MP:00053719.7HOXA10, TERC, PTEN, PGR, ESR1
3MP:00107719.6CDH1, ESR1, PGR, PTEN, MLH1, TERC
4MP:00053819.6HOXA10, TERC, MLH1, PTEN, ESR1, CDH1
5MP:00053799.3CDH1, HOXA10, TERC, MLH3, MLH1, PTEN
6MP:00053899.3HOXA10, TERC, MLH3, MLH1, PTEN, SULT1E1
7MP:00053909.3HOXA10, TERC, PTEN, PGR, ESRRA, ESR1
8MP:00053769.0TERC, MLH1, PTEN, SULT1E1, PGR, ESRRA

Publications for Endometrial Carcinoma

About this section
Sources:
53PubMed
See all sources

Articles related to Endometrial Carcinoma:

(show top 50)    (show all 1231)
idTitleAuthorsYear
1
Relationship between PTEN, DNA mismatch repair, and tumor histotype in endometrial carcinoma: retained positive expression of PTEN preferentially identifies sporadic non-endometrioid carcinomas. (23599155)
2013
2
Effects of ectopic HER-2/neu gene expression on the COX-2/PGE2/P450arom signaling pathway in endometrial carcinoma cells: HER-2/neu gene expression in endometrial carcinoma cells. (23453006)
2013
3
Secondary analyses from a randomized clinical trial: age as the key prognostic factor in endometrial carcinoma. (24361787)
2013
4
ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas. (22266854)
2012
5
Evaluation of depth of myometrial invasion by magnetic resonance imaging in patients with endometrial carcinoma. (23185792)
2012
6
Uterine endometrial carcinoma: 10 years' experience with long-term follow-up at a single Korean institution. (23075517)
2012
7
Markers for individualised therapy in endometrial carcinoma. (22846840)
2012
8
Weekly paclitaxel-carboplatin regimen in patients with primary advanced or recurrent endometrial carcinoma. (22426408)
2012
9
Aberrant expression of the von Hippel-Lindau gene in human endometrial hyperplasia and endometrial carcinoma. (21436690)
2011
10
Retrospective analysis on coexisting ovarian cancer in 976 patients with clinical stage I endometrial carcinoma. (21314805)
2011
11
Phosphatase and tensin homolog gene inhibits the effect induced by gonadotropin-releasing hormone subtypes in human endometrial carcinoma cells. (20529558)
2010
12
Mast cells: Are they really related to invasiveness of endometrial carcinoma? (20188490)
2010
13
Serum proteomic profile analysis for endometrial carcinoma detection with MALDI-TOF MS. (22371754)
2010
14
Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium. (19130400)
2009
15
Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints. (18977806)
2009
16
Endometrial carcinoma clinical management: results of a regional survey. (20099502)
2009
17
Local biosynthesis of estrogen in human endometrial carcinoma through tumor-stromal cell interactions. (19789322)
2009
18
Management of surgical stage III and IV endometrioid endometrial carcinoma: an overview. (19407572)
2009
19
Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas: analysis of inhibin/activin-alpha, -betaA and -betaB subunits in 302 cases. (19231155)
2009
20
CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium. (18619643)
2008
21
Immunohistochemical bcl-2 expression, p53 overexpression, PR and ER status in endometrial carcinoma and survival outcomes. (18386458)
2008
22
An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: a Gynecologic Oncology Group study. (17945336)
2008
23
Raloxifene, a selective estrogen receptor modulator, induces mitochondria-mediated apoptosis in human endometrial carcinoma cells. (18807138)
2008
24
Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations. (18507030)
2008
25
Expression of retinoic acid receptors in human endometrial carcinoma. (18271925)
2008
26
Endometrial carcinoma: pathology and genetics. (17365824)
2007
27
Expression of LIV-1 mRNA in human cervical carcinoma and endometrial carcinoma]. (17959546)
2007
28
Increased expression of hypoxia-inducible factor 1alpha in type I and type II endometrial carcinomas. (17099695)
2007
29
Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants. (16735506)
2006
30
Comparison of letrozole and exemestane used in non-adjuvant therapy of endometrial carcinoma]. (15909811)
2005
31
High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer. (15904949)
2005
32
Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray. (15272278)
2005
33
S100 as an immunohistochemically-detected marker with prognostic significance in endometrial carcinoma. (16033094)
2005
34
A significance of immunohistochemical determination of steroid receptors, cell proliferation factor Ki-67 and protein p53 in endometrial carcinoma. (15047211)
2004
35
VEGF expression and its reguration by p53 gene transfection in endometrial carcinoma cells. (12971625)
2003
36
A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. (10926805)
2000
37
PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 cases. (10746673)
2000
38
Molecular and cytokinetic pretreatment risk assessment in endometrial carcinoma. (10739683)
2000
39
VEGF, flt-1, and KDR/flk-1 as prognostic indicators in endometrial carcinoma. (10620438)
2000
40
Effects of tamoxifen on steroid hormone receptors and hormone concentration and the results of DNA analysis by flow cytometry in endometrial carcinoma. (10053103)
1999
41
Determination of a normal level of serum CA125 in postmenopausal women as a tool for preoperative evaluation and postoperative surveillance of endometrial carcinoma. (9648586)
1998
42
Differential inhibitory effects on human endometrial carcinoma cell growth of luteinizing hormone-releasing hormone analogues. (9887238)
1998
43
Bcl-2 and p53 expression in stage I endometrial carcinoma. (9854478)
1998
44
Expression of pS2 protein in endometrial carcinomas: correlation with clinicopathologic features and sex steroid receptor status. (9221798)
1997
45
Gi protein activation of gonadotropin-releasing hormone-mediated protein dephosphorylation in human endometrial carcinoma. (9065184)
1997
46
Mutational analysis of the BRCA1 tumor suppressor gene in endometrial carcinoma. (9299260)
1997
47
Overexpression of p53 protein is an independent prognostic indicator in human endometrial carcinoma. (8761370)
1996
48
Decreased E-cadherin expression in endometrial carcinoma is associated with tumor dedifferentiation and deep myometrial invasion. (8188077)
1994
49
Presence of gonadotropin-releasing hormone receptor and its messenger ribonucleic acid in endometrial carcinoma and endometrium. (7959256)
1994
50
Aromatase activity and the effect of estradiol and testosterone on DNA synthesis in endometrial carcinoma cell lines. (8476779)
1993

Variations for Endometrial Carcinoma

About this section
Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Endometrial Carcinoma:

65
id Symbol AA change Variation ID SNP ID
1PTENp.His123TyrVAR_026260

Clinvar genetic disease variations for Endometrial Carcinoma:

1 (show all 12)
id Gene Name Type Significance SNP ID Assembly Location
1CDH1NM_004360.3(CDH1): c.2131C> G (p.Leu711Val)single nucleotide variantPathogenic, Uncertain significancers121964871GRCh37Chr 16, 68857496: 68857496
2CDH1NM_004360.3(CDH1): c.1849G> A (p.Ala617Thr)single nucleotide variantBenign, Pathogenicrs33935154GRCh37Chr 16, 68856041: 68856041
3KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
4KRASNM_033360.3(KRAS): c.40G> A (p.Val14Ile)single nucleotide variantPathogenicrs104894365GRCh37Chr 12, 25398279: 25398279
5FGFR2NM_000141.4(FGFR2): c.755C> G (p.Ser252Trp)single nucleotide variantPathogenicrs79184941GRCh37Chr 10, 123279677: 123279677
6FGFR2NM_000141.4(FGFR2): c.1124A> G (p.Tyr375Cys)single nucleotide variantPathogenicrs121913478GRCh37Chr 10, 123274794: 123274794
7MUTYHNM_001128425.1(MUTYH): c.536A> G (p.Tyr179Cys)single nucleotide variantPathogenicrs34612342GRCh37Chr 1, 45798475: 45798475
8MUTYHNM_001128425.1(MUTYH): c.1187G> A (p.Gly396Asp)single nucleotide variantPathogenicrs36053993GRCh37Chr 1, 45797228: 45797228
9MLH3NM_001040108.1(MLH3): c.2221G> T (p.Val741Phe)single nucleotide variantPathogenicrs28756990GRCh37Chr 14, 75514138: 75514138
10MLH3MLH3, 1-BP DEL, 885GdeletionPathogenic
11PTENNM_000314.4(PTEN): c.253+1G> Asingle nucleotide variantPathogenicGRCh37Chr 10, 89690847: 89690847
12MSH3NM_002439.4(MSH3): c.1148delA (p.Lys383Argfs)deletionPathogenicGRCh38Chr 5, 80675103: 80675103

Expression for genes affiliated with Endometrial Carcinoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endometrial Carcinoma

Search GEO for disease gene expression data for Endometrial Carcinoma.

Pathways for genes affiliated with Endometrial Carcinoma

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 56Reactome
See all sources

Pathways related to Endometrial Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CDH1, ESR1, PTEN
2
Show member pathways
Signal transduction PTEN pathway61
10.0CDH1, PTEN, MLH1
3
Show member pathways
Nuclear Receptors39
10.0ESR1, ESRRA, PGR

Compounds for genes affiliated with Endometrial Carcinoma

About this section
Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
See all sources

Compounds related to Endometrial Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1ici 1643844610.5PGR, ESR1
2idoxifene4610.4PGR, ESR1
3taxane4610.4PTEN, PGR, ESR1
4onapristone46 3011.3PGR, ESR1, HPR
5fulvestrant46 52 30 1213.3ESR1, ESRRA, PGR
6chi 24610.3MLH1, IFI27, CDH1
7phtpp62 3011.3ESR1, ESRRA
8crcs4610.2CDH1, PTEN, MLH1
9indole-3-carbinol4610.2PTEN, ESR1, IFI27, CDH1
10eb 108946 6211.2IFI27, ESR1, PTEN
11danazol46 25 1212.2HSD17B13, PGR, ESR1, CDH1
12trastuzumab46 52 1212.2IFI27, ESR1, PGR, PTEN
13nomegestrol acetate4610.2ESR1, PGR, SULT1E1, HSD17B13
14dpn6210.2ESRRA, ESR1
15gefitinib46 52 1212.2CDH1, IFI27, ESR1, PTEN
16tibolone4610.2HSD17B13, SULT1E1, PGR, ESR1
17estrone sulfate46 2511.2HSD17B13, SULT1E1, PGR, ESR1
1817beta-hydroxysteroid4610.2ESR1, PGR, SULT1E1, HSD17B13
195-aza-2deoxycytidine4610.2MLH1, PTEN, PGR, ESR1, CDH1
20ppt62 3011.1ESRRA, ESR1
21steroidal4610.1PGR, ESR1, IFI27, HPR
22mifepristone46 30 62 1213.1HPR, ESR1, PGR, SULT1E1
23agar4610.1CDH1, TDGF1P3, PGR, PTEN, TERC
24estrone46 30 25 1213.1HSD17B13, SULT1E1, PGR, ESR1
25resveratrol46 62 25 1213.1SULT1E1, PGR, ESR1, IFI27
26zk11299330 4611.1PGR, HPR
27mg 13246 6211.1PTEN, ESR1, IFI27, CDH1
28sulindac46 1211.1CDH1, IFI27, MLH1
29troglitazone46 30 62 1213.1CDH1, IFI27, ESRRA, PTEN
30ici 182,7806210.0ESRRA, ESR1
31dihydrotestosterone46 30 25 1213.0HSD17B13, PGR, ESR1, CDH1
325fluorouracil4610.0TERC, MLH1, PTEN, PGR, ESR1, CDH1
33diethylstilbestrol46 30 1212.0HOXA10, PTEN, SULT1E1, PGR, ESRRA, ESR1
34progestins4610.0HSD17B13, SULT1E1, PGR, ESR1, HPR
35retinoid469.9HSD17B13, PGR, ESR1, IFI27, CDH1
36paclitaxel46 52 1211.9MLH1, PTEN, PGR, ESR1, IFI27, CDH1
37cisplatin46 52 62 1212.9TERC, MLH1, PTEN, ESR1, IFI27, CDH1
38(z)-4-hydroxytamoxifen629.8ESRRA, ESR1
39progestin469.8HSD17B13, SULT1E1, PGR, ESR1, HPR, CDH1
40doxorubicin46 52 1211.8TERC, MLH1, PTEN, PGR, ESR1, IFI27
41paraffin469.8TERC, MLH1, PTEN, PGR, ESR1, IFI27
42genistein46 30 62 3 25 1214.8PTEN, SULT1E1, PGR, ESRRA, ESR1, IFI27
43vegf469.7MLH1, PTEN, PGR, ESR1, ANG, IFI27
44estradiol46 25 1211.5HOXA10, HSD17B13, PTEN, SULT1E1, PGR, ESR1
45tamoxifen46 52 30 1212.1TERC, CDH1, HSD17B13, PTEN, SULT1E1, PGR
46testosterone46 62 25 1212.1SULT1E1, PTEN, HSD17B13, HOXA10, PGR, ESRRA
47retinoic acid46 2510.0TERC, MLH1, PTEN, PGR, ESRRA, ESR1
48steroid468.9HOXA10, MLH1, HSD17B13, PTEN, SULT1E1, PGR
49estrogen468.3ESRRA, ESR1, MMP26, IFI27, HPR, UCN
50progesterone46 30 62 25 1212.3TERC, MLH1, HSD17B13, PTEN, SULT1E1, PGR

GO Terms for genes affiliated with Endometrial Carcinoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Endometrial Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chiasmaGO:00571210.3MLH1, MLH3
2MutLbeta complexGO:03239010.2MLH1, MLH3
3mismatch repair complexGO:03230010.2MLH1, MLH3
4synaptonemal complexGO:00079510.2MLH1, MLH3
5Schmidt-Lanterman incisureGO:04322010.1PTEN, CDH1
6male germ cell nucleusGO:0016739.9MLH1, MLH3

Biological processes related to Endometrial Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1progesterone receptor signaling pathwayGO:05084710.2KLF9, PGR
2negative regulation of gene expressionGO:01062910.1UCN, ESR1, PGR
3negative regulation of cell sizeGO:04579210.1UCN, PTEN
4response to estradiolGO:03235510.0PTEN, ESR1, UCN
5transcription initiation from RNA polymerase II promoterGO:00636710.0ESR1, ESRRA, PGR
6mismatch repairGO:0062989.9MLH1, MLH3

Molecular functions related to Endometrial Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MutSalpha complex bindingGO:03240710.2MLH1, MLH3
2steroid bindingGO:0054969.7ESR1, ESRRA, PGR, SULT1E1
3steroid hormone receptor activityGO:0037079.7ESR1, ESRRA, PGR

Products for genes affiliated with Endometrial Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endometrial Carcinoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet