MCID: END080
MIFTS: 42

Endometrial Disease

Categories: Reproductive diseases

Aliases & Classifications for Endometrial Disease

MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 14
Endometrial Disorder 51 69
Endometrial Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1005
NCIt 46 C3504
SNOMED-CT 64 418632009

Summaries for Endometrial Disease

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to progesterone resistance and peritonitis. An important gene associated with Endometrial Disease is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Pathways in cancer. The drugs Bupivacaine and Mepivacaine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, ovary and colon, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Endometrial Disease

Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 progesterone resistance 30.1 ERRFI1 ESR1
2 peritonitis 29.0 CXCL8 IL1B IL6
3 endometriosis 27.8 CXCL8 CYP19A1 ESR1 IL1B IL6 PTGS2
4 progesterone-receptor positive breast cancer 10.5 CYP19A1 ESR1
5 gender identity disorder 10.5 CYP19A1 ESR1
6 estrogen excess 10.4 CYP19A1 ESR1
7 vulvar vestibulitis syndrome 10.4 ESR1 IL1B
8 mammographic density 10.4 CYP19A1 ESR1
9 prosthetic joint infection 10.4 IL1B TLR4
10 peptic esophagitis 10.3 CXCL8 IL1B
11 postmenopausal atrophic vaginitis 10.3 ESR1 OXT
12 pouchitis 10.3 CXCL8 TLR4
13 haemophilus influenzae 10.3 CXCL8 IL1B
14 opisthorchiasis 10.3 CXCL8 IL1B
15 endometrial stromal sarcoma 10.3 CXCL8 CYP19A1 ESR1
16 suppurative otitis media 10.3 IL1B TLR4
17 campylobacteriosis 10.2 IL1B TLR4
18 vaginal discharge 10.2 DSPP HP PGF
19 dental fluorosis 10.2 DSPP ESR1
20 myoma 10.2 CYP19A1 ESR1 OXT
21 acute generalized exanthematous pustulosis 10.2 CXCL8 PTGS2
22 leukoregulin 10.1 CXCL8 PTGS2
23 middle ear disease 10.1 CXCL8 IL1B TLR4
24 lymphadenitis 10.1 CXCL8 IL1B TLR4
25 osteoporotic fracture 10.1 ESR1 IL6
26 dental pulp disease 10.1 CXCL8 DSPP IL1B
27 ductal carcinoma in situ 10.1 CYP19A1 ESR1 PTGS2
28 helicobacter pylori infection 10.1 CXCL8 IL1B TLR4
29 visceral leishmaniasis 10.1 CXCL8 IL1B TLR4
30 acute endometritis 10.1 NLRC5 PTGS2
31 crohn's colitis 10.1 CXCL8 IL1B
32 cervical incompetence 10.0 IL6 SERPINH1
33 periodontitis, chronic 10.0 IL1B IL6
34 acute transverse myelitis 10.0 CXCL8 IL6
35 streptococcal toxic-shock syndrome 10.0 CXCL8 IL6
36 adenomyosis 10.0 ESR1 PTGS2
37 uremic pruritus 10.0 IL1B IL6
38 pharyngitis 10.0 CXCL8 IL1B PTGS2
39 denture stomatitis 10.0 CXCL8 IL6
40 euthyroid sick syndrome 10.0 IL1B IL6
41 gastric ulcer 10.0 CXCL8 IL1B PTGS2
42 laryngitis 10.0 IL1B IL6
43 peptic ulcer disease 10.0 CXCL8 IL1B PTGS2
44 stomach disease 10.0 CXCL8 IL1B PTGS2
45 papillary conjunctivitis 10.0 CXCL8 IL6
46 gastroesophageal reflux 9.9 CXCL8 IL1B PTGS2
47 gastritis 9.9 CXCL8 IL1B PTGS2
48 ascaris lumbricoides infection 9.9 IL1B IL6
49 acute pyelonephritis 9.9 CXCL8 IL6 PGF
50 anterior uveitis 9.9 IL6 TLR4

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease

Symptoms & Phenotypes for Endometrial Disease

MGI Mouse Phenotypes related to Endometrial Disease:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 PTGS2 IL1B ESR1 IL6 OXT CYP19A1
2 growth/size/body region MP:0005378 10.19 ERRFI1 IL6 IL1B PTGS2 OXT SERPINH1
3 homeostasis/metabolism MP:0005376 10.16 HP ERRFI1 IL6 IL1B PTGS2 OXT
4 hematopoietic system MP:0005397 10.13 HP ERRFI1 IL6 IL1B PTGS2 NLRC5
5 immune system MP:0005387 10.13 ERRFI1 IL6 IL1B PTGS2 NLRC5 ESR1
6 digestive/alimentary MP:0005381 10.11 ERRFI1 IL6 PTGS2 ESR1 SERPINH1 OXT
7 adipose tissue MP:0005375 10.08 IL6 PTGS2 ESR1 OXT CYP19A1 PGF
8 integument MP:0010771 10.06 PTGS2 IL1B ESR1 OXT CYP19A1 TLR4
9 neoplasm MP:0002006 9.92 PTGS2 IL1B ESR1 IL6 TLR4 PGF
10 liver/biliary system MP:0005370 9.91 ERRFI1 IL6 PTGS2 ESR1 CYP19A1 HP
11 renal/urinary system MP:0005367 9.86 PTGS2 ESR1 OXT CYP19A1 TLR4 HP
12 reproductive system MP:0005389 9.7 ERRFI1 IL6 PTGS2 OXT ESR1 CYP19A1
13 respiratory system MP:0005388 9.5 ERRFI1 IL6 PTGS2 SERPINH1 ESR1 PGF
14 skeleton MP:0005390 9.23 ERRFI1 IL6 IL1B PTGS2 SERPINH1 ESR1

Drugs & Therapeutics for Endometrial Disease

Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
2
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5 Central Nervous System Depressants Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Pharmaceutical Solutions Phase 4
8
Misoprostol Approved Phase 3 59122-46-2 5282381
9
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
10
Tamoxifen Approved Phase 3 10540-29-1 2733526
11
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
12 Antacids Phase 3
13 Anti-Ulcer Agents Phase 3
14 Gastrointestinal Agents Phase 3
15 Oxytocics Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Bone Density Conservation Agents Phase 3
18 Contraceptive Agents Phase 3
19 Contraceptive Agents, Male Phase 3
20 Contraceptives, Oral Phase 3
21 Estrogen Antagonists Phase 3
22 Estrogen Receptor Modulators Phase 3
23 Estrogens Phase 3
24 Hormone Antagonists Phase 3
25 Hormones Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27
Medroxyprogesterone Phase 3 520-85-4 10631
28 Selective Estrogen Receptor Modulators Phase 3
29 Citrate Nutraceutical Phase 3
30
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
31
Lenograstim Approved, Investigational Phase 2 135968-09-1
32
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
33 Adjuvants, Immunologic Phase 2
34 Albumin-Bound Paclitaxel Phase 2
35 Antimitotic Agents Phase 2
36 Antineoplastic Agents, Phytogenic Phase 2
37 Epoetin alfa 113427-24-0
38 Hematinics

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Role of Intrauterine Cornual Block in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 Misoprostol Administration Before Operative Hysteroscopy Completed NCT01805115 Phase 3 Oral misoprostol;Sublingual misoprostol;Vaginal misoprostol;Control
3 S9630, Medroxyprogesterone in Treating Women With Breast Cancer Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
4 Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness Recruiting NCT03067623 Phase 2 PRP
5 Weekly Paclitaxel/Carboplatin With Neupogen in Gynaecological Cancers Active, not recruiting NCT01523678 Phase 2 Filgrastim;Paclitaxel;Carboplatin
6 A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer Withdrawn NCT02127151 Phase 2 BMN 673
7 Fast Versus Slow Tenaculum Placement Unknown status NCT02716636
8 REM (Risk Of Endometrial Malignancy) Completed NCT01830192
9 Proliferative Effects of Erythropoietin on Human Endometrium Completed NCT03060603 Erythropoietin
10 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Recruiting NCT03289468
11 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Recruiting NCT02691715
12 Can the iKnife Distinguish Between Normal and Malignant Endometrial Tissue? Recruiting NCT03207074
13 Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss Recruiting NCT03027479
14 Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Recruiting NCT03351673 Not Applicable

Search NIH Clinical Center for Endometrial Disease

Genetic Tests for Endometrial Disease

Anatomical Context for Endometrial Disease

MalaCards organs/tissues related to Endometrial Disease:

38
Skeletal Muscle, Ovary, Colon

Publications for Endometrial Disease

Articles related to Endometrial Disease:

(show all 23)
# Title Authors Year
1
Tissue and circulating microRNA influence reproductive function in endometrial disease. ( 24055529 )
2013
2
CyclinD1, a prominent prognostic marker for endometrial diseases. ( 23947899 )
2013
3
Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. ( 22384417 )
2011
4
Progesterone resistance and endometrial disease. Preface. ( 20104423 )
2010
5
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. ( 19439667 )
2009
6
Performance of office hysteroscopy and endometrial biopsy for detecting endometrial disease in women at risk of human non-polyposis colon cancer: a prospective study. ( 18217965 )
2008
7
Endometrial disorders in patients with peritoneal serous papillary carcinoma. ( 16860923 )
2007
8
The role of Pipelle Mark II sampling in endometrial disease diagnosis. ( 17029754 )
2007
9
Reproducibility of endometrial vascular patterns in endometrial disease as assessed by transvaginal power Doppler sonography in women with postmenopausal bleeding. ( 16439778 )
2006
10
Clinical inquiries. Can transvaginal ultrasound detect endometrial disease among asymptomatic postmenopausal patients? ( 15581447 )
2004
11
Outpatient hysteroscopy and ultrasonography in the management of endometrial disease. ( 15232484 )
2004
12
Is pipelle biopsy really adequate for diagnosing endometrial disease? ( 15173672 )
2004
13
Diagnosis of premalignant endometrial disease. ( 11986334 )
2002
14
Evaluation of outpatient hysteroscopy and ultrasonography in the diagnosis of endometrial disease. ( 12052590 )
2002
15
Transvaginal uterine ultrasonography compared with endometrial biopsy for the detection of endometrial disease in perimenopausal women with uterine bleeding. ( 12168877 )
2002
16
Role of aromatase in endometrial disease. ( 11850203 )
2001
17
An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. ( 11174482 )
2001
18
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11354070 )
2001
19
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11084170 )
2000
20
Is endometriosis an endometrial disease? ( 10869783 )
2000
21
Assessment of hypermethylated DNA in two promoter regions of the estrogen receptor alpha gene in human endometrial diseases. ( 10620447 )
2000
22
Endometrial disease diagnosed by transvaginal ultrasound and dilatation and curettage. ( 10326888 )
1999
23
Endometrial thickness in tamoxifen-treated patients: an independent predictor of endometrial disease. ( 10362171 )
1999

Variations for Endometrial Disease

Expression for Endometrial Disease

Search GEO for disease gene expression data for Endometrial Disease.

Pathways for Endometrial Disease

Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 CXCL8 IL1B IL6 PTGS2 TLR4
2 12.72 CXCL8 ESR1 IL6 PGF PTGS2
3
Show member pathways
12.6 CXCL8 IL1B IL6 NLRC5
4
Show member pathways
12.58 IL1B IL6 PGF TLR4
5
Show member pathways
12.47 CXCL8 IL6 PTGS2 TLR4
6
Show member pathways
12.42 CXCL8 IL1B IL6 TLR4
7
Show member pathways
12.22 CXCL8 IL1B IL6 PTGS2
8
Show member pathways
12.07 CXCL8 IL1B IL6 TLR4
9
Show member pathways
12.04 CXCL8 IL1B IL6
10
Show member pathways
12.01 CXCL8 IL1B IL6 PTGS2 TLR4
11 11.88 CXCL8 IL1B IL6 PTGS2
12 11.86 IL1B IL6 PTGS2
13 11.84 CXCL8 IL1B IL6
14
Show member pathways
11.83 IL1B IL6 TLR4
15 11.79 CXCL8 IL1B IL6
16 11.79 CXCL8 IL1B IL6 TLR4
17 11.77 CXCL8 IL1B PTGS2 TLR4
18
Show member pathways
11.76 CXCL8 IL6 TLR4
19
Show member pathways
11.74 IL1B IL6 TLR4
20 11.73 CXCL8 IL1B IL6 TLR4
21 11.67 CXCL8 IL1B IL6 TLR4
22 11.59 CXCL8 IL1B IL6 TLR4
23 11.57 CXCL8 IL1B IL6
24
Show member pathways
11.47 CXCL8 IL1B IL6 PTGS2
25 11.46 CXCL8 IL6 PTGS2
26 11.39 CYP19A1 IL1B IL6
27 11.3 CXCL8 IL1B IL6 TLR4
28 11.26 IL1B IL6 TLR4
29 11.15 CXCL8 IL1B IL6 PTGS2
30 11.1 CXCL8 IL1B IL6 PTGS2 TLR4
31 10.95 CXCL8 IL1B IL6 TLR4
32 10.91 CXCL8 IL6 PTGS2
33 10.7 IL1B IL6
34 10.17 CYP19A1 ESR1

GO Terms for Endometrial Disease

Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CXCL8 HP IL1B IL6 OXT PGF

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL1B IL6 TLR4
2 regulation of receptor activity GO:0010469 9.77 CXCL8 IL1B IL6 OXT PGF
3 positive regulation of angiogenesis GO:0045766 9.76 CXCL8 IL1B PGF
4 cellular response to lipopolysaccharide GO:0071222 9.74 CXCL8 IL6 TLR4
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 ESR1 IL1B IL6
6 response to estradiol GO:0032355 9.67 ESR1 OXT PTGS2
7 cellular response to mechanical stimulus GO:0071260 9.65 IL1B PTGS2 TLR4
8 regulation of inflammatory response GO:0050727 9.63 ESR1 PTGS2 TLR4
9 positive regulation of chemokine production GO:0032722 9.58 IL6 TLR4
10 response to glucocorticoid GO:0051384 9.58 IL6 OXT PTGS2
11 androgen metabolic process GO:0008209 9.56 CYP19A1 ESR1
12 uterus development GO:0060065 9.55 CYP19A1 ESR1
13 negative regulation of collagen biosynthetic process GO:0032966 9.52 ERRFI1 IL6
14 induction of positive chemotaxis GO:0050930 9.51 CXCL8 PGF
15 positive regulation of prostaglandin secretion GO:0032308 9.43 IL1B OXT
16 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B IL6 TLR4
17 inflammatory response GO:0006954 9.35 CXCL8 IL1B IL6 PTGS2 TLR4
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 IL1B PTGS2 TLR4
19 positive regulation of fever generation GO:0031622 9.32 IL1B PTGS2
20 positive regulation of NF-kappaB import into nucleus GO:0042346 8.8 IL1B PTGS2 TLR4

Sources for Endometrial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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