MCID: END031
MIFTS: 46

Endometrial Stromal Sarcoma malady

Rare diseases, Reproductive diseases, Cancer diseases categories

Aliases & Classifications for Endometrial Stromal Sarcoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 61UMLS, 44Novoseek, 39NCIt, 33MeSH, 56SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Endometrial Stromal Sarcoma:

Name: Endometrial Stromal Sarcoma 8 42 10 48 61
Ess 8 42
Endometrial Stromal Sarcoma, High Grade 8
Undifferentiated Endometrial Sarcoma 8
 
Stromal Sarcoma of the Corpus Uteri 48
Undifferentiated Stromal Sarcoma 61
Sarcoma Endometrial Stromal 44


Classifications:



External Ids:

Disease Ontology8 DOID:4226
NCIt39 C8973
MeSH33 D018203
Orphanet48 213711
SNOMED-CT56 70555003
MESH via Orphanet34 D018203
ICD10 via Orphanet26 C50
UMLS via Orphanet62 C0206630

Summaries for Endometrial Stromal Sarcoma

About this section
Wikipedia:64 Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma... more...

MalaCards based summary: Endometrial Stromal Sarcoma, also known as ess, is related to sarcoma and leiomyomatosis. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoplasmic microtubules. The compounds toluidine and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and reproductive system.

Related Diseases for Endometrial Stromal Sarcoma

About this section

Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.4ACTC1, DES, VIM
2leiomyomatosis31.1PGR
3adenofibroma31.1INHA
4uterine sarcoma31.0MME, DES
5lymphangioleiomyomatosis30.9DES, PGR
6hemangiopericytoma30.5VIM, DES, ACTC1
7smooth muscle tumor30.4DES, ACTC1, MME, PGR, VIM
8leiomyoma30.4VIM, PGR, DES, ACTC1, MME
9leiomyosarcoma30.3DES, PGR, ACTC1, VIM, MME, INHA
10breast cancer30.0SULT1E1, PGR, INHA, MME
11adenocarcinoma29.5INHA, SULT1E1, PGR, MME, ACTC1, VIM
12endometriosis10.9
13empty sella syndrome10.6
14cellular leiomyoma10.6
15uterine corpus endometrial stromal sarcoma10.5
16cervical endometrial stromal sarcoma10.5
17infantile myofibromatosis10.5DES
18vaginal endometrial stromal sarcoma10.5
19uterine carcinosarcoma10.5
20peritonitis10.5
21adenomyosis10.5
22fasciitis10.5ACTC1
23secretory meningioma10.4VIM
24adenomatoid tumor10.4VIM
25myoma10.4
26endometrial stromal nodule10.4
27intravenous leiomyomatosis10.4
28cervicitis10.4
29endometrial stromal tumor10.4
30vaginitis10.4
31ductal carcinoma in situ10.3PGR
32desmoid disease, hereditary10.3DES, ACTC1
33cutaneous fibrous histiocytoma10.3ACTC1, DES
34embryonal rhabdomyosarcoma10.3ACTC1, DES
35mesenchymal chondrosarcoma10.3VIM, DES
36alveolar soft-part sarcoma10.3DES, VIM
37peutz-jeghers syndrome10.2
38renal cell carcinoma10.2
39ossifying fibromyxoid tumor10.2
40ovarian brenner tumor10.2
41portal vein thrombosis10.2
42intussusception10.2
43hydronephrosis10.2
44cerebritis10.2
45endometrial adenocarcinoma10.2
46intestinal obstruction10.2
47mediastinitis10.2
48pulmonary embolism10.2
49cerebellar degeneration10.2
50cystadenoma10.2MME, INHA

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Symptoms for Endometrial Stromal Sarcoma

About this section

Drugs & Therapeutics for Endometrial Stromal Sarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

About this section

Anatomical Context for Endometrial Stromal Sarcoma

About this section

MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

31
Uterus, Smooth muscle, Breast, Lung, Colon, Ovary, Lymph node, Bone, Heart, Liver, Brain, Skeletal muscle, Placenta, Testes, Cervix, Monocytes

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Endometrial Stromal Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PGR, VIM, ACTC1
2MP:00053898.1VIM, PGR, SULT1E1, INHA
3MP:00053858.0DES, INHA, PGR, VIM, ACTC1
4MP:00053766.7ACTC1, MME, VIM, PGR, SULT1E1, INHA

Publications for Endometrial Stromal Sarcoma

About this section

Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 427)
idTitleAuthorsYear
1
Vulvar extrauterine endometrial stromal sarcoma: A case report and literature review. (25585306)
2015
2
Fatal case of multiple recurrences of endometrial stromal sarcoma after fertility-sparing management. (25163509)
2014
3
Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors-molecular characterization shows genetic overlap with endometrial stromal sarcoma. (24285434)
2014
4
A very late recurrence of a formerly misdiagnosed low grade endometrial stromal sarcoma metastasized to the colon. (24240082)
2013
5
Extragenital endometrial stromal sarcoma arising in endometriosis. (22538201)
2012
6
A well circumscribed uterine endometrial stromal tumor with smooth muscle differentiation recurred as a low grade endometrial stromal sarcoma: is tumor margin enough for the diagnosis? (22524669)
2012
7
Cerebral metastases of an endometrial stromal sarcoma: report of the first case. (22868507)
2012
8
Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. (22982899)
2012
9
Tyrosine kinase receptor status in endometrial stromal sarcoma: an immunohistochemical and genetic-molecular analysis. (23018215)
2012
10
High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis. (20730890)
2011
11
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
12
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases. (21652246)
2011
13
Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. (20354812)
2011
14
Endometrial stromal sarcoma from endometriosis. (20728821)
2010
15
Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma: three case reports. (21495227)
2010
16
Low-grade endometrial stromal sarcoma: a single center's experience with 22 cases. (18179547)
2008
17
Multilocular intrauterine cystic mass, atypical presentation of endometrial stromal sarcoma: a case report. (18040707)
2008
18
Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases. (19031927)
2008
19
Pulmonary metastases from endometrial stromal sarcoma may benefit from hormone therapy]. (17268368)
2007
20
Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. (17972504)
2007
21
Pathogenetic mechanisms in endometrial stromal sarcoma. (18000370)
2007
22
The cytogenetics and molecular biology of endometrial stromal sarcoma. (18000369)
2007
23
Sonographic findings of uterine endometrial stromal sarcoma. (17143032)
2006
24
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
25
Do drugs that stimulate ovulation increase the risk for endometrial stromal sarcoma? (15788697)
2005
26
Metastatic low-grade endometrial stromal sarcoma of the sigmoid colon three years after hysterectomy. (15818757)
2005
27
JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. (16049311)
2005
28
Pathologic quiz case: a 46-year-old woman with 1-day history of abdominal pain and intestinal obstruction. Extrauterine low-grade endometrial stromal sarcoma. (15679447)
2005
29
Endometrial stromal sarcoma--observational evidence of a genetic background? (15991528)
2005
30
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
31
Surgical cytoreduction and hormone therapy of an advanced endometrial stromal sarcoma of the ovary. (15121605)
2004
32
Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study. (14631363)
2004
33
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. (14751141)
2004
34
MIB1 as a possible predictor of recurrence in low-grade endometrial stromal sarcoma of the uterus. (12893199)
2003
35
Surgery and adjuvant radiation therapy of endometrial stromal sarcoma. (12407935)
2002
36
Polypoid uterine lesions mimicking endometrial stromal sarcoma. (10605413)
1999
37
Unilateral hydronephrosis and recurrent endometrial stromal sarcoma with review of the literature. (10443046)
1999
38
Endometrial stromal sarcoma involving the placenta. (9845753)
1998
39
A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). (9309124)
1997
40
Endometrial stromal sarcoma diagnosed by operative hysteroscopy. (9021394)
1996
41
Endometrial stromal sarcoma invading the bladder. (8221003)
1993
42
Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness. (1562530)
1992
43
Endometrial stromal sarcoma of the uterus. A clinical and histopathological study. The Radiumhemmet series 1936-1981. (2335259)
1990
44
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
45
Chronic obstruction of the inferior vena cava with recurrent endometrial stromal sarcoma. (2429400)
1986
46
Hemangiopericytoma of the uterus vs. hemangiopericytoma-like endometrial stromal sarcoma: a histopathological approach to differential diagnosis. (4054418)
1985
47
Ultrastructure of endometrial stromal sarcoma. (1111916)
1975
48
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
49
Endometrial stromal sarcoma. (5729399)
1968
50
Endometrial stromal sarcoma. (13999681)
1963

Variations for Endometrial Stromal Sarcoma

About this section

Expression for genes affiliated with Endometrial Stromal Sarcoma

About this section
Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

About this section

Pathways related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.6VIM, DES
2
Show member pathways
9.5MME, INHA
39.4INHA, PGR
49.2ACTC1, VIM, DES
5
Show member pathways
9.2ACTC1, VIM, DES

Compounds for genes affiliated with Endometrial Stromal Sarcoma

About this section

Compounds related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1toluidine449.9VIM, DES
22-methoxyethanol449.9VIM, ACTC1
3phalloidin449.8DES, VIM
4gemfibrozil28 44 1111.8DES, VIM
5actomyosin449.7VIM, ACTC1
6orcein449.6DES, ACTC1, VIM
7s 100449.6ACTC1, VIM, DES
8reticulin449.6ACTC1, VIM, DES
9mucicarmine449.6VIM, DES, ACTC1
10b 723449.6ACTC1, DES, VIM
11procollagen449.6DES, ACTC1, VIM
12formaldehyde44 2410.5ACTC1, DES, VIM
13bezafibrate44 28 1111.5VIM, DES
14bromodeoxyuridine449.4VIM, MME, DES
15leupeptin449.4MME, VIM
16nomegestrol acetate449.4PGR, SULT1E1
1712-o-tetradecanoylphorbol 13-acetate449.4VIM, DES, MME
18tibolone449.3SULT1E1, PGR
19matrigel449.3ACTC1, VIM, MME
20dihydrotestosterone44 28 24 1112.3PGR, DES, VIM
21methionine449.3VIM, MME, DES
22glycogen44 2410.3ACTC1, VIM, DES
23acetylcholine44 50 28 24 1113.3VIM, MME, DES
24estrone sulfate44 2410.2SULT1E1, PGR
25hematoxylin449.2INHA, ACTC1, VIM, DES
26biotin44 24 1111.1ACTC1, INHA, VIM, DES
27vitamin a44 24 1111.1PGR, MME, VIM
28actinomycin d449.1MME, DES, VIM
29heparan sulfate44 2410.1VIM, SULT1E1, DES
30indomethacin44 28 60 1112.1VIM, PGR, MME
31creatinine449.0DES, VIM, MME, ACTC1
32forskolin44 50 1111.0MME, VIM, INHA
33ribonucleic acid448.9ACTC1, MME, INHA, PGR
34adriamycin448.9DES, PGR, MME, VIM
35doxorubicin44 50 1110.8VIM, MME, PGR, DES
36adenylate448.8VIM, PGR, MME, DES
37tamoxifen44 50 28 1111.8SULT1E1, VIM, PGR
38gnrh448.8PGR, MME, INHA, VIM
39dexamethasone44 50 28 1111.8ACTC1, PGR, MME, VIM
40cysteine448.7PGR, MME, VIM, DES
41progestin448.6SULT1E1, PGR, VIM, DES
42vegf448.4DES, ACTC1, MME, VIM, PGR
43retinoic acid44 249.4MME, DES, PGR, VIM, ACTC1
44genistein44 28 60 1 24 1113.2SULT1E1, PGR, VIM
45estradiol44 24 1110.1PGR, SULT1E1, INHA, DES, VIM
46paraffin448.0PGR, VIM, MME, INHA, DES, ACTC1
47steroid447.7INHA, DES, SULT1E1, PGR, MME, ACTC1
48progesterone44 28 60 24 1111.2MME, ACTC1, VIM, PGR, SULT1E1, INHA
49testosterone44 60 24 1110.2MME, INHA, ACTC1, VIM, PGR, DES
50estrogen447.2MME, DES, INHA, SULT1E1, PGR, VIM

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

About this section

Cellular components related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.6VIM, DES

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.2ACTC1, VIM, DES

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.6VIM, DES
2steroid bindingGO:00054968.7PGR, SULT1E1

Sources for Endometrial Stromal Sarcoma

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet