ESS
MCID: END031
MIFTS: 56

Endometrial Stromal Sarcoma (ESS) malady

Reproductive diseases, Cancer diseases categories

Summaries for Endometrial Stromal Sarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma... more...

MalaCards: Endometrial Stromal Sarcoma, also known as ESS, is related to sarcoma and endometriosis. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Estrogen biosynthesis and Glycoprotein hormones. The compounds goserelin and orcein have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are homeostasis/metabolism and reproductive system.

Aliases & Classifications for Endometrial Stromal Sarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

endometrial stromal sarcoma 8 42 10 48 60
ess 8 42
endometrial stromal sarcoma, high grade 8
undifferentiated endometrial sarcoma 8
stromal sarcoma of the corpus uteri 48
sarcoma endometrial stromal 44


External Ids:

Disease Ontology8 DOID:4226
NCIt39 C8973
MeSH34 D018203
SNOMED-CT56 70555003
UMLS via Orphanet61 C0206630
MESH via Orphanet35 D018203
ICD10 via Orphanet26 C50

Related Diseases for Endometrial Stromal Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.2ERBB3, VIM, ACTC1, DES
2endometriosis31.3ACTC1, CYP19A1, OXTR, PGR, GNRHR
3leiomyosarcoma31.0ACTC1, INHA, PGR, VIM, DES, MME
4smooth muscle tumor30.9PGR, MME, DES, VIM, ACTC1
5leiomyoma30.8GNRHR, MME, ACTC1, CYP19A1, DES, OXTR
6breast cancer30.7INHA, SULT1E1, MME, ERBB3, S100A6, PGR
7endometrial carcinoma30.6PGR, INHA, MME
8adenocarcinoma30.6ACTC1, INHA, MME, GNRHR, VIM, SULT1E1
9leiomyomatosis30.5PGR
10lymphangioleiomyomatosis30.5PGR, DES
11myoma30.5PGR, GNRHR, CYP19A1
12adenofibroma30.2INHA
13hemangiopericytoma30.2ACTC1, VIM, DES
14endometrial stromal tumor10.8
15colon sarcoma10.6
16lung sarcoma10.6
17cellular leiomyoma10.5
18cervical endometrial stromal sarcoma10.5
19breast sarcoma10.5
20ovary sarcoma10.5
21vaginal endometrial stromal sarcoma10.5
22endometrial stromal nodule10.5
23uterine corpus endometrial stromal sarcoma10.5
24empty sella syndrome10.5
25uterine carcinosarcoma10.4
26endometrial adenocarcinoma10.4
27heart sarcoma10.4
28peritonitis10.4
29retroperitoneal sarcoma10.4
30vagina sarcoma10.4
31intravenous leiomyomatosis10.3
32mixed endometrial stromal and smooth muscle tumor10.3
33cervicitis10.3
34liver sarcoma10.3
35pulmonary embolism10.3
36vaginitis10.3
37uterine inversion10.2
38ovarian brenner tumor10.2
39ossifying fibromyxoid tumor10.2
40mast-cell sarcoma10.2
41ovarian endometriosis10.2
42endometriosis of ovary10.2
43hydronephrosis10.2
44cerebritis10.2
45brain sarcoma10.2
46portal vein thrombosis10.2
47intussusception10.2
48endometrial squamous cell carcinoma10.2
49bladder sarcoma10.2
50cervical cancer10.2

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Clinical Features for Endometrial Stromal Sarcoma

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Drugs & Therapeutics for Endometrial Stromal Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endometrial Stromal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Search CenterWatch for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

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Anatomical Context for Endometrial Stromal Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

32
Uterus, Smooth muscle, Breast, Lung, Colon, Ovary, Lymph node, Bone, Heart, Liver, Skeletal muscle, Brain, Placenta, Testes, Cervix, Monocytes

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endometrial Stromal Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9SULT1E1, ACTC1, PGR, DES, GNRHR, SFRP4
2MP:00053899.9SFRP4, GNRHR, OXTR, INHA, SULT1E1
3MP:00053699.7VIM, DES, OXTR, CYP19A1, PGR, ACTC1
4MP:00053799.7GNRHR, OXTR, INHA, SULT1E1
5MP:00028739.7ERBB3, ACTC1, PGR, INHA, CYP19A1, OXTR
6MP:00053859.5VIM, SFRP4, DES, CYP19A1, INHA, PGR

Publications for Endometrial Stromal Sarcoma

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Sources:
50PubMed
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Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 399)
idTitleAuthorsYear
1
Endometrial stromal sarcoma with intracaval extension at initial presentation. (23967567)
2013
2
Tyrosine kinase receptor status in endometrial stromal sarcoma: an immunohistochemical and genetic-molecular analysis. (23018215)
2012
3
High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis. (20730890)
2011
4
Spinal metastasis of endometrial stromal sarcoma: clinicopathological features and management. (21071207)
2011
5
Unexpected findings on gallium-67 scintigraphy: detection of undifferentiated endometrial stromal sarcoma. (21220978)
2011
6
Endometrial stromal sarcoma developed on outer endometriosis foci. (21424099)
2011
7
High levels of xenoestrogens in patients with low-grade endometrial stromal sarcoma--report of two cases. (20349793)
2010
8
Megestrol acetate therapy for advanced low-grade endometrial stromal sarcoma. (20502061)
2010
9
Clinical characteristics of endometrial stromal sarcoma from an academic medical hospital in China. (21370596)
2010
10
Endometrial stromal sarcoma diagnosed after uterine morcellation in laparoscopic supracervical hysterectomy. (20955991)
2010
11
Stage IA vs. IB endometrial stromal sarcoma: does the new staging system predict survival? (20447684)
2010
12
Low-grade endometrial stromal sarcoma: a single center's experience with 22 cases. (18179547)
2008
13
Establishment and characterization of a cell line (OMC-9) originating from a human endometrial stromal sarcoma. (18397474)
2008
14
Treatment options in stage I endometrial stromal sarcoma: a retrospective analysis of 53 cases. (18061249)
2008
15
Endometrial stromal sarcoma: clinico-pathological report of four cases and review of the literature. (18516335)
2008
16
Pulmonary metastases from endometrial stromal sarcoma may benefit from hormone therapy]. (17268368)
2007
17
The cytogenetics and molecular biology of endometrial stromal sarcoma. (18000369)
2007
18
A multi-institutional review of outcomes of endometrial stromal sarcoma. (17320937)
2007
19
Hormonal therapy of endometrial stromal sarcoma. (17545798)
2007
20
Expression of platelet-derived growth factor receptor in low-grade endometrial stromal sarcomas in the absence of activating mutations. (17448020)
2007
21
Endometrial stromal sarcoma with smooth muscle and glandular differentiation of the feline uterus. (17491081)
2007
22
Phenotypic characterization of endometrial stromal sarcoma of the uterus. (16441420)
2006
23
Low grade endometrial stromal sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases. (16895611)
2006
24
Uterine epithelioid endometrial stromal sarcoma presenting as a "cervical polyp". (15806518)
2005
25
Distinction of endometrial stromal sarcomas from 'hemangiopericytomatous' tumors using a panel of immunohistochemical stains. (15309019)
2005
26
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. (14751141)
2004
27
Multicystic endometrial stromal sarcoma. (15290672)
2004
28
Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas. (15307134)
2004
29
Multi-focal extra-uterine endometrial stromal sarcoma (ESS): a very rare complication of endometriosis associated with elevated serum CA-125. (16985314)
2003
30
Low-grade endometrial stromal sarcoma: hormonal aspects. (12821359)
2003
31
Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma. (12665689)
2003
32
Parenchymatous pulmonary endometriosis - metastases of a low-grade endometrial stromal sarcoma? (14592802)
2003
33
Radiation therapy in the treatment of endometrial stromal sarcoma. (11172957)
2001
34
Endometrial stromal sarcoma of the rectosigmoid colon arising in extragonadal endometriosis and revealed by portal vein thrombosis. (11473465)
2001
35
Low-grade endometrial stromal sarcoma of the ectocervix after therapy for breast cancer. (11006043)
2000
36
Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel. (10898543)
2000
37
High-grade endometrial stromal sarcoma (HG-ESS) in an adolescent girl with benign mediastinal Schwannoma. (15512279)
1999
38
Endometrial stromal sarcoma of the heart. (9345834)
1997
39
Granulosa cell tumor arising in the ovary irradiated 22 years earlier for endometrial stromal sarcoma. (21594325)
1996
40
Mixed low grade and high grade endometrial stromal sarcoma of uterus: differences on immunohistochemistry and chromosome in situ hybridisation. (8813967)
1996
41
Adenomyosis with sparse glands. A potential mimic of low-grade endometrial stromal sarcoma. (7856566)
1995
42
Endometrial stromal sarcoma with clonal chromosomal aberrations and mixed phenotype. (7497450)
1995
43
High-grade endometrial stromal sarcoma: clinicopathologic and immunohistochemical study of a case. (7936769)
1994
44
Endometrial stromal sarcoma invading the bladder. (8221003)
1993
45
Leiomyosarcoma (LMS) and endometrial stromal sarcoma (ESS) of the uterus. A survey of patients treated in the Norwegian Radium Hospital 1976-1985. (11578330)
1993
46
Endometrial stromal sarcoma two years after a successful in-vitro fertilization treatment cycle. (1551963)
1992
47
An endometrial stromal sarcoma with clonal cytogenetic abnormalities. (1933818)
1991
48
Uterine malignancy developing after a long term use of IUCD. Additional report of a case: association of endometrial stromal sarcoma with IUCD. (4038174)
1985
49
Nonpuerperal inversion of the uterus by endometrial stromal sarcoma of the uterine fundus. (560064)
1977
50
Fine structure of endometrial stromal sarcoma. (4920397)
1970

Genetic Variations for Endometrial Stromal Sarcoma

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Expression for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endometrial Stromal Sarcoma

Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3SULT1E1, CYP19A1
2
Hide members
10.2GNRHR2, GNRHR
3
Hide members
10.2VIM, DES, ACTC1
410.2PGR, INHA, CYP19A1

Compounds for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1goserelin44 28 1112.8GNRHR
2orcein4410.6ACTC1, VIM, DES
3s 1004410.6ACTC1, DES, VIM
4reticulin4410.6ACTC1, DES, VIM
5mucicarmine4410.6ACTC1, DES, VIM
6cetrorelix acetate5910.5GNRHR, GNRHR2
7leuprolide acetate4410.5CYP19A1, PGR, GNRHR
8Gonadorelin1110.5GNRHR2, GNRHR
9buserelin44 28 1112.5GNRHR, CYP19A1, PGR
10ag 0455725910.5GNRHR, GNRHR2
11nafarelin44 59 28 1113.5CYP19A1, GNRHR, GNRHR2
12goserelin acetate5910.5GNRHR, GNRHR2
13tibolone4410.5SULT1E1, CYP19A1, PGR
14idoxifene4410.5CYP19A1, PGR
15lapatinib44 49 1112.5ERBB3, CYP19A1, PGR
16hematoxylin4410.5VIM, INHA, DES, ACTC1
17b 7234410.5DES, VIM, ACTC1
18danazol44 11 2412.4CYP19A1, GNRHR2, PGR, GNRHR
1917beta-hydroxysteroid4410.4S100A6, CYP19A1, SULT1E1, PGR
20mifepristone44 59 28 1113.4OXTR, CYP19A1, SULT1E1, PGR
21progestins4410.4SULT1E1, PGR, CYP19A1, S100A6
22dihydrotestosterone44 28 11 2413.4GNRHR, PGR, CYP19A1, DES, VIM
23steroidal4410.4CYP19A1, OXTR, PGR
24estrone sulfate44 2411.4CYP19A1, PGR, SULT1E1
25adriamycin4410.4MME, VIM, DES, PGR
26biotin44 11 2412.4VIM, INHA, DES, ACTC1
27dexamethasone44 49 28 1113.3MME, OXTR
28indomethacin44 59 28 1113.3PGR, MME, VIM, CYP19A1, OXTR
29ribonucleic acid4410.3ACTC1, GNRHR, MME, OXTR, INHA, PGR
30formaldehyde44 2411.3VIM, CYP19A1, DES, ACTC1
31forskolin44 49 1112.2VIM, ERBB3, MME, GNRHR, OXTR, INHA
32adenylate4410.2OXTR, MME, DES, GNRHR, PGR, VIM
33megestrol44 1111.2PGR, CYP19A1
34diethylstilbestrol44 28 1112.2CYP19A1, SULT1E1, PGR
35doxorubicin44 49 1112.2VIM, ERBB3, MME, CYP19A1, PGR, GNRHR
36acetaldehyde44 28 2412.1VIM, DES, H2BFS
37tamoxifen44 49 28 1113.1OXTR, PGR, GNRHR, ERBB3, SULT1E1, CYP19A1
38progestin4410.1SULT1E1, DES, VIM, S100A6, PGR, OXTR
39vegf4410.1OXTR, DES, PGR, MME, ACTC1, VIM
40arginine4410.1MME, VIM, GNRHR, DES, OXTR, CYP19A1
41genistein44 28 59 2 11 2415.0ERBB3, VIM, SULT1E1, PGR, CYP19A1
42gnrh4410.0VIM, PGR, INHA, CYP19A1, OXTR, GNRHR2
43paraffin4410.0INHA, MME, PGR, S100A6, VIM, DES
44retinoic acid44 2411.0VIM, S100A6, DES, CYP19A1, PGR, MME
45estradiol44 11 2411.9OXTR, VIM, GNRHR, DES, CYP19A1, ERBB3
46oligonucleotide449.9VIM, ERBB3, INHA, OXTR, GNRHR, S100A6
473beta-hydroxysteroid449.9PGR, CYP19A1, INHA
48steroid449.7GNRHR, DES, OXTR, CYP19A1, S100A6, INHA
49testosterone44 59 11 2412.6CYP19A1, DES, GNRHR, S100A6, ERBB3, INHA
50progesterone44 59 28 11 2413.4SFRP4, S100A6, GNRHR, OXTR, CYP19A1, INHA

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

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16Gene Ontology
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Cellular components related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ESC/E(Z) complexGO:03509810.2SUZ12, PHF1
2extracellular vesicular exosomeGO:0700629.9ACTC1, YWHAE, VIM

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.2ACTC1, DES, VIM

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gonadotropin-releasing hormone receptor activityGO:00496810.2GNRHR2, GNRHR

Products for genes affiliated with Endometrial Stromal Sarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endometrial Stromal Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet