ESS
MCID: END031
MIFTS: 53

Endometrial Stromal Sarcoma (ESS) malady

Rare diseases, Reproductive diseases, Cancer diseases categories

Summaries for Endometrial Stromal Sarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma... more...

MalaCards: Endometrial Stromal Sarcoma, also known as ESS, is related to sarcoma and leiomyosarcoma. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoplasmic microtubules. The compounds toluidine and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and reproductive system.

Aliases & Classifications for Endometrial Stromal Sarcoma

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt, 64UMLS via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

endometrial stromal sarcoma 9 44 11 50 63
ess 9 44
endometrial stromal sarcoma, high grade 9
undifferentiated endometrial sarcoma 9
stromal sarcoma of the corpus uteri 50
sarcoma endometrial stromal 46


External Ids:

Disease Ontology9 DOID:4226
MeSH36 D018203
NCIt41 C8973
SNOMED-CT59 70555003
UMLS via Orphanet64 C0206630
MESH via Orphanet37 D018203
ICD10 via Orphanet27 C50

Related Diseases for Endometrial Stromal Sarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.3DES, VIM, ACTC1
2leiomyosarcoma30.9DES, INHA, PGR, VIM, ACTC1, MME
3smooth muscle tumor30.8DES, PGR, VIM, MME, ACTC1
4leiomyoma30.8DES, PGR, VIM, MME, ACTC1
5leiomyomatosis30.7PGR
6uterine sarcoma30.7MME, DES
7lymphangioleiomyomatosis30.6PGR, DES
8breast cancer30.6INHA, SULT1E1, PGR, MME
9adenofibroma30.5INHA
10adenocarcinoma30.4INHA, SULT1E1, PGR, VIM, MME, ACTC1
11hemangiopericytoma30.4DES, VIM, ACTC1
12endometrial carcinoma30.3MME, PGR, SULT1E1
13endometriosis10.9
14empty sella syndrome10.6
15cellular leiomyoma10.6
16uterine corpus endometrial stromal sarcoma10.5
17cervical endometrial stromal sarcoma10.5
18peritonitis10.5
19adenomyosis10.5
20myoma10.4
21endometrial stromal nodule10.4
22vaginal endometrial stromal sarcoma10.4
23uterine carcinosarcoma10.4
24intravenous leiomyomatosis10.4
25cervicitis10.4
26vaginitis10.4
27ossifying fibromyxoid tumor10.2
28ovarian brenner tumor10.2
29portal vein thrombosis10.2
30intussusception10.2
31ovarian endometriosis10.2
32hydronephrosis10.2
33cerebritis10.2
34cervical cancer10.2
35endometrial adenocarcinoma10.2
36endometrial stromal tumor10.2
37intestinal obstruction10.2
38mediastinitis10.2
39renal cell carcinoma10.2
40cerebellar degeneration10.2
41sepsis10.2
42infantile myofibromatosis10.1DES
43fasciitis10.1ACTC1
44secretory meningioma10.1VIM
45adenomatoid tumor10.1VIM
46ductal carcinoma in situ10.1PGR
47desmoid tumor10.1ACTC1, DES
48cutaneous fibrous histiocytoma10.1ACTC1, DES
49embryonal rhabdomyosarcoma10.1ACTC1, DES
50mesenchymal chondrosarcoma10.1VIM, DES

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Symptoms for Endometrial Stromal Sarcoma

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Drugs & Therapeutics for Endometrial Stromal Sarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Endometrial Stromal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Search CenterWatch for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

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Anatomical Context for Endometrial Stromal Sarcoma

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34MalaCards
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MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

34
Uterus, Smooth muscle, Breast, Lung, Colon, Ovary, Lymph node, Heart, Bone, Liver, Skeletal muscle, Testes, Brain, Placenta, Monocytes, Cervix

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Endometrial Stromal Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PGR, VIM, ACTC1
2MP:00053898.1VIM, PGR, SULT1E1, INHA
3MP:00053858.0DES, INHA, PGR, VIM, ACTC1
4MP:00053766.7ACTC1, MME, VIM, PGR, SULT1E1, INHA

Publications for Endometrial Stromal Sarcoma

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53PubMed
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Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 394)
idTitleAuthorsYear
1
Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors-molecular characterization shows genetic overlap with endometrial stromal sarcoma. (24285434)
2014
2
A very late recurrence of a formerly misdiagnosed low grade endometrial stromal sarcoma metastasized to the colon. (24240082)
2013
3
Extragenital endometrial stromal sarcoma arising in endometriosis. (22538201)
2012
4
A well circumscribed uterine endometrial stromal tumor with smooth muscle differentiation recurred as a low grade endometrial stromal sarcoma: is tumor margin enough for the diagnosis? (22524669)
2012
5
Cerebral metastases of an endometrial stromal sarcoma: report of the first case. (22868507)
2012
6
Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. (22982899)
2012
7
Tyrosine kinase receptor status in endometrial stromal sarcoma: an immunohistochemical and genetic-molecular analysis. (23018215)
2012
8
Endometrial stromal sarcoma in a 29-year-old patient. Case report and review of the literature. (22873114)
2012
9
High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis. (20730890)
2011
10
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
11
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases. (21652246)
2011
12
Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. (20354812)
2011
13
Endometrial stromal sarcoma from endometriosis. (20728821)
2010
14
Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma: three case reports. (21495227)
2010
15
Low-grade endometrial stromal sarcoma: a single center's experience with 22 cases. (18179547)
2008
16
Multilocular intrauterine cystic mass, atypical presentation of endometrial stromal sarcoma: a case report. (18040707)
2008
17
Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases. (19031927)
2008
18
Pulmonary metastases from endometrial stromal sarcoma may benefit from hormone therapy]. (17268368)
2007
19
Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. (17972504)
2007
20
Pathogenetic mechanisms in endometrial stromal sarcoma. (18000370)
2007
21
The cytogenetics and molecular biology of endometrial stromal sarcoma. (18000369)
2007
22
Sonographic findings of uterine endometrial stromal sarcoma. (17143032)
2006
23
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
24
Do drugs that stimulate ovulation increase the risk for endometrial stromal sarcoma? (15788697)
2005
25
Metastatic low-grade endometrial stromal sarcoma of the sigmoid colon three years after hysterectomy. (15818757)
2005
26
JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. (16049311)
2005
27
Pathologic quiz case: a 46-year-old woman with 1-day history of abdominal pain and intestinal obstruction. Extrauterine low-grade endometrial stromal sarcoma. (15679447)
2005
28
Endometrial stromal sarcoma--observational evidence of a genetic background? (15991528)
2005
29
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
30
Surgical cytoreduction and hormone therapy of an advanced endometrial stromal sarcoma of the ovary. (15121605)
2004
31
Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study. (14631363)
2004
32
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. (14751141)
2004
33
MIB1 as a possible predictor of recurrence in low-grade endometrial stromal sarcoma of the uterus. (12893199)
2003
34
Surgery and adjuvant radiation therapy of endometrial stromal sarcoma. (12407935)
2002
35
Polypoid uterine lesions mimicking endometrial stromal sarcoma. (10605413)
1999
36
Unilateral hydronephrosis and recurrent endometrial stromal sarcoma with review of the literature. (10443046)
1999
37
Endometrial stromal sarcoma involving the placenta. (9845753)
1998
38
A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). (9309124)
1997
39
Endometrial stromal sarcoma diagnosed by operative hysteroscopy. (9021394)
1996
40
Endometrial stromal sarcoma invading the bladder. (8221003)
1993
41
Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness. (1562530)
1992
42
Endometrial stromal sarcoma of the uterus. A clinical and histopathological study. The Radiumhemmet series 1936-1981. (2335259)
1990
43
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
44
Chronic obstruction of the inferior vena cava with recurrent endometrial stromal sarcoma. (2429400)
1986
45
Hemangiopericytoma of the uterus vs. hemangiopericytoma-like endometrial stromal sarcoma: a histopathological approach to differential diagnosis. (4054418)
1985
46
Ultrastructure of endometrial stromal sarcoma. (1111916)
1975
47
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
48
Fine structure of endometrial stromal sarcoma. (4920397)
1970
49
Endometrial stromal sarcoma. (5729399)
1968
50
Endometrial stromal sarcoma. (13999681)
1963

Variations for Endometrial Stromal Sarcoma

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Expression for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endometrial Stromal Sarcoma

Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 61Thomson Reuters, 56Reactome, 5Cell Signaling Technology
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Pathways related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.6VIM, DES
2
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.6VIM, DES
3
Show member pathways
9.5MME, INHA
49.4INHA, PGR
59.2ACTC1, VIM, DES
6
Show member pathways
9.2ACTC1, VIM, DES

Compounds for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1toluidine469.9DES, VIM
22-methoxyethanol469.9ACTC1, VIM
3phalloidin469.8VIM, DES
4gemfibrozil30 46 1211.8DES, VIM
5actomyosin469.7ACTC1, VIM
6orcein469.6DES, VIM, ACTC1
7s 100469.6DES, VIM, ACTC1
8reticulin469.6DES, VIM, ACTC1
9mucicarmine469.6ACTC1, VIM, DES
10b 723469.6DES, VIM, ACTC1
11procollagen469.6ACTC1, VIM, DES
12formaldehyde46 2510.5ACTC1, VIM, DES
13bezafibrate46 30 1211.5DES, VIM
14bromodeoxyuridine469.4MME, VIM, DES
15leupeptin469.4MME, VIM
16nomegestrol acetate469.4PGR, SULT1E1
1712-o-tetradecanoylphorbol 13-acetate469.4MME, VIM, DES
18tibolone469.3PGR, SULT1E1
19matrigel469.3VIM, MME, ACTC1
20dihydrotestosterone46 30 25 1212.3DES, PGR, VIM
21methionine469.3MME, VIM, DES
22glycogen46 2510.3ACTC1, VIM, DES
23acetylcholine46 52 30 25 1213.3MME, VIM, DES
24estrone sulfate46 2510.2PGR, SULT1E1
25hematoxylin469.2ACTC1, VIM, INHA, DES
26biotin46 25 1211.1ACTC1, VIM, INHA, DES
27vitamin a46 25 1211.1MME, VIM, PGR
28actinomycin d469.1DES, VIM, MME
29heparan sulfate46 2510.1DES, SULT1E1, VIM
30indomethacin46 30 62 1212.1PGR, VIM, MME
31creatinine469.0DES, VIM, MME, ACTC1
32forskolin46 52 1211.0MME, VIM, INHA
33ribonucleic acid468.9INHA, PGR, MME, ACTC1
34adriamycin468.9MME, VIM, PGR, DES
35doxorubicin46 52 1210.8DES, PGR, VIM, MME
36adenylate468.8DES, PGR, VIM, MME
37tamoxifen46 52 30 1211.8SULT1E1, PGR, VIM
38gnrh468.8MME, VIM, PGR, INHA
39dexamethasone46 52 30 1211.8PGR, VIM, MME, ACTC1
40cysteine468.7DES, PGR, VIM, MME
41progestin468.6DES, SULT1E1, PGR, VIM
42vegf468.4DES, PGR, VIM, MME, ACTC1
43retinoic acid46 259.4ACTC1, MME, VIM, PGR, DES
44genistein46 30 62 3 25 1213.2VIM, PGR, SULT1E1
45estradiol46 25 1210.1DES, INHA, SULT1E1, PGR, VIM
46paraffin468.0DES, INHA, PGR, VIM, MME, ACTC1
47steroid467.7DES, INHA, SULT1E1, PGR, MME, ACTC1
48progesterone46 30 62 25 1211.2ACTC1, DES, INHA, SULT1E1, PGR, VIM
49testosterone46 62 25 1210.2DES, INHA, SULT1E1, PGR, VIM, MME
50estrogen467.2DES, INHA, SULT1E1, PGR, VIM, MME

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

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17Gene Ontology
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Cellular components related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.6VIM, DES

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.2ACTC1, VIM, DES

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.6VIM, DES
2steroid bindingGO:0054968.7PGR, SULT1E1

Products for genes affiliated with Endometrial Stromal Sarcoma

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Sources for Endometrial Stromal Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet