MCID: END031
MIFTS: 46

Endometrial Stromal Sarcoma malady

Rare diseases, Reproductive diseases, Cancer diseases categories

Summaries for Endometrial Stromal Sarcoma

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Wikipedia:63 Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma... more...

MalaCards based summary: Endometrial Stromal Sarcoma, also known as ess, is related to sarcoma and leiomyomatosis. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoplasmic microtubules. The compounds toluidine and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and reproductive system.

Aliases & Classifications for Endometrial Stromal Sarcoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 43Novoseek, 38NCIt, 33MeSH, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Endometrial Stromal Sarcoma, Aliases & Descriptions:

Name: Endometrial Stromal Sarcoma 9 41 11 47 60
Ess 9 41
Endometrial Stromal Sarcoma, High Grade 9
Undifferentiated Endometrial Sarcoma 9
 
Stromal Sarcoma of the Corpus Uteri 47
Undifferentiated Stromal Sarcoma 60
Sarcoma Endometrial Stromal 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:4226
NCIt38 C8973
MeSH33 D018203
Orphanet47 213711
SNOMED-CT55 70555003
MESH via Orphanet34 D018203
ICD10 via Orphanet26 C50
UMLS via Orphanet61 C0206630

Related Diseases for Endometrial Stromal Sarcoma

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Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.4ACTC1, DES, VIM
2leiomyomatosis31.1PGR
3adenofibroma31.1INHA
4uterine sarcoma31.0MME, DES
5lymphangioleiomyomatosis30.9DES, PGR
6hemangiopericytoma30.5VIM, DES, ACTC1
7smooth muscle tumor30.4DES, ACTC1, MME, PGR, VIM
8leiomyoma30.4VIM, PGR, DES, ACTC1, MME
9leiomyosarcoma30.3DES, PGR, ACTC1, VIM, MME, INHA
10breast cancer30.0SULT1E1, PGR, INHA, MME
11adenocarcinoma29.5INHA, SULT1E1, PGR, MME, ACTC1, VIM
12endometriosis10.9
13empty sella syndrome10.6
14cellular leiomyoma10.6
15uterine corpus endometrial stromal sarcoma10.5
16cervical endometrial stromal sarcoma10.5
17infantile myofibromatosis10.5DES
18vaginal endometrial stromal sarcoma10.5
19uterine carcinosarcoma10.5
20peritonitis10.5
21adenomyosis10.5
22fasciitis10.5ACTC1
23secretory meningioma10.4VIM
24adenomatoid tumor10.4VIM
25myoma10.4
26endometrial stromal nodule10.4
27intravenous leiomyomatosis10.4
28cervicitis10.4
29endometrial stromal tumor10.4
30vaginitis10.4
31ductal carcinoma in situ10.3PGR
32desmoid disease, hereditary10.3DES, ACTC1
33cutaneous fibrous histiocytoma10.3ACTC1, DES
34embryonal rhabdomyosarcoma10.3ACTC1, DES
35mesenchymal chondrosarcoma10.3VIM, DES
36alveolar soft-part sarcoma10.3DES, VIM
37peutz-jeghers syndrome10.2
38renal cell carcinoma10.2
39ossifying fibromyxoid tumor10.2
40ovarian brenner tumor10.2
41portal vein thrombosis10.2
42intussusception10.2
43hydronephrosis10.2
44cerebritis10.2
45endometrial adenocarcinoma10.2
46intestinal obstruction10.2
47mediastinitis10.2
48pulmonary embolism10.2
49cerebellar degeneration10.2
50cystadenoma10.2MME, INHA

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Symptoms for Endometrial Stromal Sarcoma

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Drugs & Therapeutics for Endometrial Stromal Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

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Anatomical Context for Endometrial Stromal Sarcoma

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MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

31
Uterus, Smooth muscle, Breast, Lung, Colon, Ovary, Lymph node, Bone, Heart, Liver, Brain, Skeletal muscle, Placenta, Testes, Cervix, Monocytes

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Endometrial Stromal Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PGR, VIM, ACTC1
2MP:00053898.1VIM, PGR, SULT1E1, INHA
3MP:00053858.0DES, INHA, PGR, VIM, ACTC1
4MP:00053766.7ACTC1, MME, VIM, PGR, SULT1E1, INHA

Publications for Endometrial Stromal Sarcoma

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Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 427)
idTitleAuthorsYear
1
Vulvar extrauterine endometrial stromal sarcoma: A case report and literature review. (25585306)
2015
2
Fatal case of multiple recurrences of endometrial stromal sarcoma after fertility-sparing management. (25163509)
2014
3
Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors-molecular characterization shows genetic overlap with endometrial stromal sarcoma. (24285434)
2014
4
A very late recurrence of a formerly misdiagnosed low grade endometrial stromal sarcoma metastasized to the colon. (24240082)
2013
5
Extragenital endometrial stromal sarcoma arising in endometriosis. (22538201)
2012
6
A well circumscribed uterine endometrial stromal tumor with smooth muscle differentiation recurred as a low grade endometrial stromal sarcoma: is tumor margin enough for the diagnosis? (22524669)
2012
7
Cerebral metastases of an endometrial stromal sarcoma: report of the first case. (22868507)
2012
8
Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. (22982899)
2012
9
Tyrosine kinase receptor status in endometrial stromal sarcoma: an immunohistochemical and genetic-molecular analysis. (23018215)
2012
10
High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis. (20730890)
2011
11
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
12
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases. (21652246)
2011
13
Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. (20354812)
2011
14
Endometrial stromal sarcoma from endometriosis. (20728821)
2010
15
Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma: three case reports. (21495227)
2010
16
Low-grade endometrial stromal sarcoma: a single center's experience with 22 cases. (18179547)
2008
17
Multilocular intrauterine cystic mass, atypical presentation of endometrial stromal sarcoma: a case report. (18040707)
2008
18
Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases. (19031927)
2008
19
Pulmonary metastases from endometrial stromal sarcoma may benefit from hormone therapy]. (17268368)
2007
20
Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. (17972504)
2007
21
Pathogenetic mechanisms in endometrial stromal sarcoma. (18000370)
2007
22
The cytogenetics and molecular biology of endometrial stromal sarcoma. (18000369)
2007
23
Sonographic findings of uterine endometrial stromal sarcoma. (17143032)
2006
24
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
25
Do drugs that stimulate ovulation increase the risk for endometrial stromal sarcoma? (15788697)
2005
26
Metastatic low-grade endometrial stromal sarcoma of the sigmoid colon three years after hysterectomy. (15818757)
2005
27
JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. (16049311)
2005
28
Pathologic quiz case: a 46-year-old woman with 1-day history of abdominal pain and intestinal obstruction. Extrauterine low-grade endometrial stromal sarcoma. (15679447)
2005
29
Endometrial stromal sarcoma--observational evidence of a genetic background? (15991528)
2005
30
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
31
Surgical cytoreduction and hormone therapy of an advanced endometrial stromal sarcoma of the ovary. (15121605)
2004
32
Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study. (14631363)
2004
33
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. (14751141)
2004
34
MIB1 as a possible predictor of recurrence in low-grade endometrial stromal sarcoma of the uterus. (12893199)
2003
35
Surgery and adjuvant radiation therapy of endometrial stromal sarcoma. (12407935)
2002
36
Polypoid uterine lesions mimicking endometrial stromal sarcoma. (10605413)
1999
37
Unilateral hydronephrosis and recurrent endometrial stromal sarcoma with review of the literature. (10443046)
1999
38
Endometrial stromal sarcoma involving the placenta. (9845753)
1998
39
A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). (9309124)
1997
40
Endometrial stromal sarcoma diagnosed by operative hysteroscopy. (9021394)
1996
41
Endometrial stromal sarcoma invading the bladder. (8221003)
1993
42
Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness. (1562530)
1992
43
Endometrial stromal sarcoma of the uterus. A clinical and histopathological study. The Radiumhemmet series 1936-1981. (2335259)
1990
44
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
45
Chronic obstruction of the inferior vena cava with recurrent endometrial stromal sarcoma. (2429400)
1986
46
Hemangiopericytoma of the uterus vs. hemangiopericytoma-like endometrial stromal sarcoma: a histopathological approach to differential diagnosis. (4054418)
1985
47
Ultrastructure of endometrial stromal sarcoma. (1111916)
1975
48
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
49
Endometrial stromal sarcoma. (5729399)
1968
50
Endometrial stromal sarcoma. (13999681)
1963

Variations for Endometrial Stromal Sarcoma

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Expression for genes affiliated with Endometrial Stromal Sarcoma

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Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

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Pathways related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.6VIM, DES
2
Show member pathways
9.5MME, INHA
39.4INHA, PGR
49.2ACTC1, VIM, DES
5
Show member pathways
9.2ACTC1, VIM, DES

Compounds for genes affiliated with Endometrial Stromal Sarcoma

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Compounds related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1toluidine439.9DES, VIM
22-methoxyethanol439.9ACTC1, VIM
3phalloidin439.8VIM, DES
4gemfibrozil28 43 1211.8DES, VIM
5actomyosin439.7ACTC1, VIM
6orcein439.6DES, VIM, ACTC1
7s 100439.6DES, VIM, ACTC1
8reticulin439.6DES, VIM, ACTC1
9mucicarmine439.6ACTC1, VIM, DES
10b 723439.6DES, VIM, ACTC1
11procollagen439.6ACTC1, VIM, DES
12formaldehyde43 2410.5ACTC1, VIM, DES
13bezafibrate43 28 1211.5DES, VIM
14bromodeoxyuridine439.4MME, VIM, DES
15leupeptin439.4MME, VIM
16nomegestrol acetate439.4PGR, SULT1E1
1712-o-tetradecanoylphorbol 13-acetate439.4MME, VIM, DES
18tibolone439.3PGR, SULT1E1
19matrigel439.3VIM, MME, ACTC1
20dihydrotestosterone43 28 24 1212.3DES, PGR, VIM
21methionine439.3MME, VIM, DES
22glycogen43 2410.3ACTC1, VIM, DES
23acetylcholine43 49 28 24 1213.3MME, VIM, DES
24estrone sulfate43 2410.2PGR, SULT1E1
25hematoxylin439.2ACTC1, VIM, INHA, DES
26biotin43 24 1211.1ACTC1, VIM, INHA, DES
27vitamin a43 24 1211.1MME, VIM, PGR
28actinomycin d439.1DES, VIM, MME
29heparan sulfate43 2410.1DES, SULT1E1, VIM
30indomethacin43 28 59 1212.1PGR, VIM, MME
31creatinine439.0DES, VIM, MME, ACTC1
32forskolin43 49 1211.0MME, VIM, INHA
33ribonucleic acid438.9INHA, PGR, MME, ACTC1
34adriamycin438.9MME, VIM, PGR, DES
35doxorubicin43 49 1210.8DES, PGR, VIM, MME
36adenylate438.8DES, PGR, VIM, MME
37tamoxifen43 49 28 1211.8SULT1E1, PGR, VIM
38gnrh438.8MME, VIM, PGR, INHA
39dexamethasone43 49 28 1211.8PGR, VIM, MME, ACTC1
40cysteine438.7DES, PGR, VIM, MME
41progestin438.6DES, SULT1E1, PGR, VIM
42vegf438.4DES, PGR, VIM, MME, ACTC1
43retinoic acid43 249.4ACTC1, MME, VIM, PGR, DES
44genistein43 28 59 2 24 1213.2VIM, PGR, SULT1E1
45estradiol43 24 1210.1DES, INHA, SULT1E1, PGR, VIM
46paraffin438.0DES, INHA, PGR, VIM, MME, ACTC1
47steroid437.7DES, INHA, SULT1E1, PGR, MME, ACTC1
48progesterone43 28 59 24 1211.2ACTC1, DES, INHA, SULT1E1, PGR, VIM
49testosterone43 59 24 1210.2DES, INHA, SULT1E1, PGR, VIM, MME
50estrogen437.2DES, INHA, SULT1E1, PGR, VIM, MME

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

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Cellular components related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.6VIM, DES

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.2ACTC1, VIM, DES

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.6VIM, DES
2steroid bindingGO:00054968.7PGR, SULT1E1

Products for genes affiliated with Endometrial Stromal Sarcoma

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Sources for Endometrial Stromal Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet