ESS
MCID: END031
MIFTS: 51

Endometrial Stromal Sarcoma (ESS) malady

Reproductive, Cancer categories

Summaries for Endometrial Stromal Sarcoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Endometrial stromal sarcoma is a rare endometrial tumor arising from the stroma (connective tissue) of... more...

MalaCards: Endometrial Stromal Sarcoma, also known as ESS, is related to uterine sarcoma and smooth muscle tumor. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Estrogen biosynthesis and Glycoprotein hormones. The compounds goserelin and orcein have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and spinal cord, and related mouse phenotypes are homeostasis/metabolism and reproductive system.

Aliases & Classifications for Endometrial Stromal Sarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Aliases & Descriptions:

endometrial stromal sarcoma 8 43 10 49 61
ess 8 43
endometrial stromal sarcoma, high grade 8
undifferentiated endometrial sarcoma 8
stromal sarcoma of the corpus uteri 49
sarcoma endometrial stromal 45


External Ids:

Disease Ontology8 DOID:4226
NCIt40 C8973
MeSH35 D018203
SNOMED-CT57 70555003
UMLS via Orphanet62 C0206630
MESH via Orphanet36 D018203
ICD10 via Orphanet26 C50

Related Diseases for Endometrial Stromal Sarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1uterine sarcoma31.5DES, CYP19A1, MME
2smooth muscle tumor30.9VIM, DES, PGR, MME, ACTC1
3adenocarcinoma30.6VIM, S100A6, GNRHR, INHA, PGR, MME
4lymphangioleiomyomatosis30.5DES, PGR
5myoma30.5DES, PGR
6adenofibroma30.3INHA
7cellular leiomyoma10.6
8cervical endometrial stromal sarcoma10.6
9vagina sarcoma10.6
10vaginal endometrial stromal sarcoma10.5
11uterine corpus endometrial stromal sarcoma10.5
12empty sella syndrome10.5
13endometrial stromal nodule10.5
14uterine carcinosarcoma10.5
15adenomyosis10.5
16intravenous leiomyomatosis10.4
17rare endometriosis10.4
18uterine inversion10.2
19ovarian brenner tumor10.2
20ossifying fibromyxoid tumor10.2
21mast-cell sarcoma10.2
22ovarian endometriosis10.2
23hydronephrosis10.2
24brain sarcoma10.2
25portal vein thrombosis10.2
26intussusception10.2
27endometrial squamous cell carcinoma10.2
28bladder sarcoma10.2
29squamous cell carcinoma10.2
30uterine corpus sarcoma10.2
31uterus leiomyosarcoma10.2
32cerebellar degeneration10.2
33cerebral sarcoma10.2
34sepsis10.2
35benign schwannoma10.2
36euthyroid sick syndrome10.0
37leiomyomatosis10.0PGR
38infantile myofibromatosis10.0DES
39ductal carcinoma in situ10.0PGR
40lipoma10.0DES
41breast fibroadenoma10.0PGR
42hemangioblastoma10.0INHA
43teratoma10.0ACTC1
44fasciitis10.0ACTC1
45hemangioma10.0ACTC1
46sertoli-leydig cell tumor10.0PGR, INHA
47lung cancer10.0ERBB3
48cystadenoma10.0INHA, MME
49congestive heart failure10.0MME
50leydig cell tumor10.0INHA, CYP19A1

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Clinical Features for Endometrial Stromal Sarcoma

Drugs & Therapeutics for Endometrial Stromal Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endometrial Stromal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Search CenterWatch for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

Anatomical Context for Endometrial Stromal Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

33
Ovary, Liver, Spinal cord, Brain, Lymph node, Lung, Uterus, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Breast, Placenta, Cervix, Monocytes, T cells, B cells, Uterus corpus

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Endometrial Stromal Sarcoma

Sources:
51PubMed
See all sources

Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 399)
idTitleAuthorsYear
1
Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors-molecular characterization shows genetic overlap with endometrial stromal sarcoma. (24285434)
2014
2
Pulmonary Embolism as a First Manifestation of Intracardiac Extension of an Endometrial Stromal Sarcoma. (24388273)
2013
3
Prognostic value of the diagnostic criteria distinguishing endometrial stromal sarcoma, low grade from undifferentiated endometrial sarcoma, 2 entities within the invasive endometrial stromal neoplasia family. (23545579)
2013
4
Transition of low-grade to high-grade endometrial stromal sarcoma: a case report. (24020149)
2013
5
Lobectomy of pulmonary metastasis of endometrial stromal sarcoma. (24318286)
2013
6
Successful use of dydrogesterone as maintenance therapy in recurrent endometrial stromal sarcoma: a case report. (24058200)
2013
7
Metastatic endometrial stromal sarcoma of the lung: importance of immunohistochemical staining, clinical history and imaging studies. (21838613)
2012
8
Incidence of uterine leiomyosarcoma and endometrial stromal sarcoma in Nordic countries: results from NORDCAN and NOCCA databases. (22377186)
2012
9
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
10
Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: expression and prognostic importance of ten different markers. (21161468)
2011
11
Incidence of lymph node and adnexal metastasis in endometrial stromal sarcoma. (21276609)
2011
12
Endometrial stromal sarcoma located in the myometrium with a low-intensity rim on T2-weighted images: report of three cases and literature review. (20373443)
2010
13
Paraneoplastic consumptive coagulopathy related to intramyometrial low-grade endometrial stromal sarcoma coexistent with adenomyosis diagnosed 7 years after laparoscopic-assisted myomectomy. (20135133)
2010
14
Diffusion-weighted imaging of uterine endometrial stromal sarcoma: a report of 2 cases. (20498539)
2010
15
Endometrial stromal sarcoma mimicking a myoma. (18937947)
2009
16
Phase 2 trial of mifepristone (RU-486) in advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma. (19241422)
2009
17
The efficacy of hormonal treatment for residual or recurrent low-grade endometrial stromal sarcoma. A retrospective study. (19269732)
2009
18
Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases. (19031927)
2008
19
Low-grade endometrial stromal sarcoma with retroperitoneal metastases: an unusual case report. (17823808)
2008
20
Lymphadenectomy and ovarian preservation in low-grade endometrial stromal sarcoma. (18978112)
2008
21
Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. (17972504)
2007
22
Clinical study investigating the role of lymphadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma. (17895898)
2007
23
Images in pathology. Endometrial stromal sarcoma with hyalinizing giant rosettes and separate leiomyoma with palisading nuclei in the same uterus. (17041196)
2006
24
PDGF-alpha and PDGF-beta are expressed in endometrial stromal sarcoma: a potential therapeutic target for tyrosine kinase inhibitors? (17064305)
2006
25
Metastatic low-grade endometrial stromal sarcoma of the sigmoid colon three years after hysterectomy. (15818757)
2005
26
The morphologic features of endometrial stromal sarcoma and its metastases]. (15938828)
2005
27
Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. (15863163)
2005
28
Should lymphadenectomy be performed in patients with endometrial stromal sarcoma? (15944001)
2005
29
Endometrial stromal sarcoma mimicking submucosal myoma protruding to the vagina: MRI findings. (16398232)
2005
30
Sonographic, CT, and MRI findings of endometrial stromal sarcoma located in the myometrium and associated with peritoneal inclusion cyst. (15150002)
2004
31
Asymptomatic intracardiac metastasis from a low-grade endometrial stromal sarcoma with successful surgical resection. (14984976)
2004
32
The diagnostic problem of endometrial stromal sarcoma: report on six cases. (12821339)
2003
33
Breast metastasis from low-grade endometrial stromal sarcoma after a 17-year period. (12439586)
2002
34
Endometrial stromal sarcoma. (15512444)
1999
35
Endometrial stromal sarcomas: immunohistochemical, electron microscopical and cytogenetic findings in two cases. (10335941)
1999
36
A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). (9309124)
1997
37
An interesting unusual case of endometrial stromal sarcoma. (9094814)
1997
38
Sonographic characteristics in low-grade endometrial stromal sarcoma: a report of two cases. (8568965)
1995
39
Endometrial stromal sarcoma with retroperitoneal metastasis in a young patient. (7705544)
1994
40
Uterine leiomyosarcoma and endometrial stromal sarcoma: lymph node metastases and sites of recurrence. (8349151)
1993
41
Extra-uterine endometrial stromal sarcoma with DNA flow cytometric analysis. (1563563)
1992
42
Endometrial stromal sarcoma t(7;17)(p15-21;q12-21) is a nonrandom chromosome change. (1423225)
1992
43
Endometrial stromal sarcoma of the uterus. (1958850)
1991
44
Progestogen-induced regression in low-grade endometrial stromal sarcoma. Case report and literature review. (2695158)
1989
45
Endometrial stromal sarcoma of low-grade malignancy. Immunohistochemical and three-dimensional reconstruction study with special emphasis on the inadequate terminology of endolymphatic stromal myosis. (2741706)
1989
46
Endometrial stromal sarcoma and leiomyosarcoma arising in adenomyosis: a possible presentation of occult extra-genital malignancy. (207980)
1978
47
Endometrial stromal sarcoma of the broad ligament arising in an area of endometriosis in a paramesonephric cyst. Case report. (843483)
1977
48
Endometrial stromal sarcoma. (5570742)
1971
49
Primary extrauterine endometrial stromal sarcoma. (5436137)
1970
50
UTERINE SARCOMA WITH SPECIAL REFERENCE TO ENDOMETRIAL STROMAL SARCOMA. (14130898)
1964

Genetic Variations for Endometrial Stromal Sarcoma

Expression for genes affiliated with Endometrial Stromal Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endometrial Stromal Sarcoma

Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database
See all sources

Pathways related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3SULT1E1, CYP19A1
2
Hide members
10.2GNRHR2, GNRHR
3
Hide members
10.2VIM, DES, ACTC1
410.2PGR, INHA, CYP19A1

Compounds for genes affiliated with Endometrial Stromal Sarcoma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1goserelin45 29 1112.8GNRHR
2orcein4510.6ACTC1, VIM, DES
3s 1004510.6ACTC1, DES, VIM
4reticulin4510.6ACTC1, DES, VIM
5mucicarmine4510.6ACTC1, DES, VIM
6cetrorelix acetate6010.5GNRHR, GNRHR2
7leuprolide acetate4510.5CYP19A1, PGR, GNRHR
8Gonadorelin1110.5GNRHR2, GNRHR
9buserelin45 29 1112.5GNRHR, CYP19A1, PGR
10ag 0455726010.5GNRHR, GNRHR2
11nafarelin45 60 29 1113.5CYP19A1, GNRHR, GNRHR2
12goserelin acetate6010.5GNRHR, GNRHR2
13tibolone4510.5SULT1E1, CYP19A1, PGR
14idoxifene4510.5CYP19A1, PGR
15lapatinib45 50 1112.5ERBB3, CYP19A1, PGR
16hematoxylin4510.5VIM, INHA, DES, ACTC1
17b 7234510.5DES, VIM, ACTC1
18danazol45 11 2412.4CYP19A1, GNRHR2, PGR, GNRHR
1917beta-hydroxysteroid4510.4S100A6, CYP19A1, SULT1E1, PGR
20mifepristone45 60 29 1113.4OXTR, CYP19A1, SULT1E1, PGR
21progestins4510.4SULT1E1, PGR, CYP19A1, S100A6
22dihydrotestosterone45 29 11 2413.4GNRHR, PGR, CYP19A1, DES, VIM
23steroidal4510.4CYP19A1, OXTR, PGR
24estrone sulfate45 2411.4CYP19A1, PGR, SULT1E1
25adriamycin4510.4MME, VIM, DES, PGR
26biotin45 11 2412.4VIM, INHA, DES, ACTC1
27dexamethasone45 50 29 1113.3MME, OXTR
28indomethacin45 60 29 1113.3PGR, MME, VIM, CYP19A1, OXTR
29ribonucleic acid4510.3ACTC1, GNRHR, MME, OXTR, INHA, PGR
30formaldehyde45 2411.3VIM, CYP19A1, DES, ACTC1
31forskolin45 50 1112.2VIM, ERBB3, MME, GNRHR, OXTR, INHA
32adenylate4510.2OXTR, MME, DES, GNRHR, PGR, VIM
33megestrol45 1111.2PGR, CYP19A1
34diethylstilbestrol45 29 1112.2CYP19A1, SULT1E1, PGR
35doxorubicin45 50 1112.2VIM, ERBB3, MME, CYP19A1, PGR, GNRHR
36acetaldehyde45 29 2412.1VIM, DES, H2BFS
37tamoxifen45 50 29 1113.1OXTR, PGR, GNRHR, ERBB3, SULT1E1, CYP19A1
38progestin4510.1SULT1E1, DES, VIM, S100A6, PGR, OXTR
39vegf4510.1OXTR, DES, PGR, MME, ACTC1, VIM
40arginine4510.1MME, VIM, GNRHR, DES, OXTR, CYP19A1
41genistein45 29 60 2 11 2415.0ERBB3, VIM, SULT1E1, PGR, CYP19A1
42gnrh4510.0VIM, PGR, INHA, CYP19A1, OXTR, GNRHR2
43paraffin4510.0INHA, MME, PGR, S100A6, VIM, DES
44retinoic acid45 2411.0VIM, S100A6, DES, CYP19A1, PGR, MME
45estradiol45 11 2411.9OXTR, VIM, GNRHR, DES, CYP19A1, ERBB3
46oligonucleotide459.9VIM, ERBB3, INHA, OXTR, GNRHR, S100A6
473beta-hydroxysteroid459.9PGR, CYP19A1, INHA
48steroid459.7GNRHR, DES, OXTR, CYP19A1, S100A6, INHA
49testosterone45 60 11 2412.6CYP19A1, DES, GNRHR, S100A6, ERBB3, INHA
50progesterone45 60 29 11 2413.4SFRP4, S100A6, GNRHR, OXTR, CYP19A1, INHA

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ESC/E(Z) complexGO:03509810.2SUZ12, PHF1
2extracellular vesicular exosomeGO:0700629.9ACTC1, YWHAE, VIM

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.2ACTC1, DES, VIM

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gonadotropin-releasing hormone receptor activityGO:00496810.2GNRHR2, GNRHR

Products for genes affiliated with Endometrial Stromal Sarcoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Endometrial Stromal Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet