ESS
MCID: END031
MIFTS: 56

Endometrial Stromal Sarcoma (ESS) malady

Reproductive diseases, Cancer diseases categories

Summaries for Endometrial Stromal Sarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma... more...

MalaCards: Endometrial Stromal Sarcoma, also known as ESS, is related to sarcoma and endometriosis. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Estrogen biosynthesis and Glycoprotein hormones. The compounds goserelin and orcein have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are homeostasis/metabolism and reproductive system.

Aliases & Classifications for Endometrial Stromal Sarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

endometrial stromal sarcoma 8 42 10 48 60
ess 8 42
endometrial stromal sarcoma, high grade 8
undifferentiated endometrial sarcoma 8
stromal sarcoma of the corpus uteri 48
sarcoma endometrial stromal 44


External Ids:

Disease Ontology8 DOID:4226
NCIt39 C8973
MeSH34 D018203
SNOMED-CT56 70555003
UMLS via Orphanet61 C0206630
MESH via Orphanet35 D018203
ICD10 via Orphanet26 C50

Related Diseases for Endometrial Stromal Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.2ERBB3, VIM, ACTC1, DES
2endometriosis31.3ACTC1, CYP19A1, OXTR, PGR, GNRHR
3leiomyosarcoma31.0ACTC1, INHA, PGR, VIM, DES, MME
4smooth muscle tumor30.9PGR, MME, DES, VIM, ACTC1
5leiomyoma30.8GNRHR, MME, ACTC1, CYP19A1, DES, OXTR
6breast cancer30.7INHA, SULT1E1, MME, ERBB3, S100A6, PGR
7endometrial carcinoma30.6PGR, INHA, MME
8adenocarcinoma30.6ACTC1, INHA, MME, GNRHR, VIM, SULT1E1
9leiomyomatosis30.5PGR
10lymphangioleiomyomatosis30.5PGR, DES
11myoma30.5PGR, GNRHR, CYP19A1
12adenofibroma30.2INHA
13hemangiopericytoma30.2ACTC1, VIM, DES
14endometrial stromal tumor10.8
15colon sarcoma10.6
16lung sarcoma10.6
17cellular leiomyoma10.5
18cervical endometrial stromal sarcoma10.5
19breast sarcoma10.5
20ovary sarcoma10.5
21vaginal endometrial stromal sarcoma10.5
22endometrial stromal nodule10.5
23uterine corpus endometrial stromal sarcoma10.5
24empty sella syndrome10.5
25uterine carcinosarcoma10.4
26endometrial adenocarcinoma10.4
27heart sarcoma10.4
28peritonitis10.4
29retroperitoneal sarcoma10.4
30vagina sarcoma10.4
31intravenous leiomyomatosis10.3
32mixed endometrial stromal and smooth muscle tumor10.3
33cervicitis10.3
34liver sarcoma10.3
35pulmonary embolism10.3
36vaginitis10.3
37uterine inversion10.2
38ovarian brenner tumor10.2
39ossifying fibromyxoid tumor10.2
40mast-cell sarcoma10.2
41ovarian endometriosis10.2
42endometriosis of ovary10.2
43hydronephrosis10.2
44cerebritis10.2
45brain sarcoma10.2
46portal vein thrombosis10.2
47intussusception10.2
48endometrial squamous cell carcinoma10.2
49bladder sarcoma10.2
50cervical cancer10.2

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Clinical Features for Endometrial Stromal Sarcoma

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Drugs & Therapeutics for Endometrial Stromal Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endometrial Stromal Sarcoma

Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Search CenterWatch for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

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Anatomical Context for Endometrial Stromal Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

32
Uterus, Smooth muscle, Breast, Lung, Colon, Ovary, Lymph node, Bone, Heart, Liver, Skeletal muscle, Placenta, Monocytes, Testes, Brain, Cervix

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Endometrial Stromal Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9SULT1E1, ACTC1, PGR, DES, GNRHR, SFRP4
2MP:00053899.9SFRP4, GNRHR, OXTR, INHA, SULT1E1
3MP:00053699.7VIM, DES, OXTR, CYP19A1, PGR, ACTC1
4MP:00053799.7GNRHR, OXTR, INHA, SULT1E1
5MP:00028739.7ERBB3, ACTC1, PGR, INHA, CYP19A1, OXTR
6MP:00053859.5VIM, SFRP4, DES, CYP19A1, INHA, PGR

Publications for Endometrial Stromal Sarcoma

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Sources:
50PubMed
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Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 399)
idTitleAuthorsYear
1
A very late recurrence of a formerly misdiagnosed low grade endometrial stromal sarcoma metastasized to the colon. (24240082)
2013
2
Cystic variant of endometrial stromal sarcoma: report of two cases. (23045333)
2013
3
A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease. (23710389)
2013
4
Endometrial stromal sarcoma arising in vagina. (24294390)
2013
5
Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement. (23211293)
2013
6
The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. (22456610)
2012
7
Long-term medroxyprogesterone acetate therapy for low-grade endometrial stromal sarcoma. (21830086)
2012
8
Endometriosis-associated serous borderline tumor and endometrial stromal sarcoma of the ovary: a report of a rare lesion in an infant. (22123729)
2012
9
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases. (21652246)
2011
10
Cystic appearance of low-grade endometrial stromal sarcoma in the right atrium: case report. (21864385)
2011
11
Recurrent endometrial stromal sarcoma in the cecum causing intussusception. (20464405)
2011
12
Recurrent endometrial stromal sarcoma: treatment with a progestin and gonadotropin releasing hormone agonist. (20613993)
2010
13
Detection of complete response to imatinib mesylate (Glivec/Gleevec) with 18F-FDG PET/CT for low-grade endometrial stromal sarcoma. (18607592)
2009
14
Endometrial stromal sarcoma: treatment and patterns of recurrence. (19574799)
2009
15
An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera. (18722875)
2008
16
SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway. (18850582)
2008
17
Immunohistochemical study of endometrial stromal sarcoma and smooth-muscle tumors of the uterus]. (18565690)
2008
18
Endometrial stromal sarcoma: a population-based analysis. (18813312)
2008
19
Current treatment options in uterine endometrial stromal sarcoma: report of a case and review of the literature. (17359294)
2007
20
Do drugs that stimulate ovulation increase the risk for endometrial stromal sarcoma? (15788697)
2005
21
Pathologic quiz case: a 46-year-old woman with 1-day history of abdominal pain and intestinal obstruction. Extrauterine low-grade endometrial stromal sarcoma. (15679447)
2005
22
Conservative management of a myxoid endometrial stromal sarcoma in a 16-year-old nulliparous woman. (16054205)
2005
23
Lymph node metastases in low-grade endometrial stromal sarcoma. (15661228)
2005
24
A case of endometrial stromal sarcoma with curvilinear calcification. (15963554)
2005
25
Endometrial stromal sarcoma arising in extrauterine endometriosis: a case report. (15755017)
2005
26
Metastatic low-grade endometrial stromal sarcoma presented as a subepithelial mass in the stomach was diagnosed by EUS-guided FNA. (16246710)
2005
27
High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer. (15920338)
2005
28
Low-grade endometrial stromal sarcoma arising from sciatic nerve endometriosis. (15516431)
2004
29
Pulmonary metastases of uterine endometrial stromal sarcoma: diffuse micronodular and ground glass opacities: a case report. (15608407)
2004
30
Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature. (12648605)
2003
31
Low-grade endometrial stromal sarcoma with an extensive epithelial-like element. (12675770)
2003
32
Test and teach. A uterine tumour causing a diagnostic dilemma. Low-grade endometrial stromal sarcoma with extensive endometrioid glandular differentiation. (12959770)
2003
33
Low-grade endometrial stromal sarcoma recurring after 9 years. (12425508)
2002
34
Uterine endometrial stromal sarcoma with smooth muscle and glandular differentiation. (11376025)
2001
35
Endometrial stromal sarcoma of the uterus: MR and US findings. (10823632)
2000
36
Expression of metalloproteinases endometrial stromal sarcoma: immunohistochemical study using image analysis. (10450179)
1999
37
Endometrial stromal sarcoma involving the placenta. (9845753)
1998
38
MaMi, a human endometrial stromal sarcoma cell line that constitutively produces interleukin-6, interleukin-8, and monocyte chemoattractant protein-1. (9740146)
1998
39
Intracaval extension of a recurrent low-grade endometrial stromal sarcoma. (9922815)
1998
40
Endometrial stromal sarcoma with sex cord-like areas and focal rhabdoid differentiation. (8910045)
1996
41
Endometrial stromal sarcoma with focal smooth muscle differentiation: recurrence after 17 years: a follow-up report with discussion of the nomenclature. (8786208)
1996
42
Uterine endometrial stromal sarcoma with rhabdoid and smooth muscle differentiation. (8703378)
1996
43
Cytogenetics revealing the diagnosis in a metastatic endometrial stromal sarcoma. (8818702)
1996
44
A case of unsuspected endometrial stromal sarcoma removed by operative hysteroscopy. (8522266)
1995
45
Myogenous phenotype of epithelial-like areas in endometrial stromal sarcomas. (2001155)
1991
46
Post-hysterectomy extra-uterine endometrial stromal sarcoma: a case report. (2283724)
1990
47
Endometrial stromal sarcoma: a report of nine cases. (2910776)
1989
48
Hemangiopericytoma of the uterus vs. hemangiopericytoma-like endometrial stromal sarcoma: a histopathological approach to differential diagnosis. (4054418)
1985
49
Endometrial stromal sarcoma and poorly differentiated endometrial sarcoma. (7127257)
1982
50
Detection of endometrial stromal sarcoma in cervicovaginal smears: reports of three cases. (6942618)
1981

Genetic Variations for Endometrial Stromal Sarcoma

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Expression for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endometrial Stromal Sarcoma

Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3SULT1E1, CYP19A1
2
Hide members
10.2GNRHR2, GNRHR
3
Hide members
10.2VIM, DES, ACTC1
410.2PGR, INHA, CYP19A1

Compounds for genes affiliated with Endometrial Stromal Sarcoma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1goserelin44 28 1112.8GNRHR
2orcein4410.6ACTC1, DES, VIM
3s 1004410.6ACTC1, DES, VIM
4reticulin4410.6VIM, DES, ACTC1
5mucicarmine4410.6VIM, DES, ACTC1
6Gonadorelin1110.5GNRHR, GNRHR2
7buserelin44 28 1112.5GNRHR, CYP19A1, PGR
8cetrorelix acetate5910.5GNRHR, GNRHR2
9leuprolide acetate4410.5GNRHR, CYP19A1, PGR
10ag 0455725910.5GNRHR, GNRHR2
11nafarelin44 59 28 1113.5GNRHR, GNRHR2, CYP19A1
12goserelin acetate5910.5GNRHR, GNRHR2
13tibolone4410.5SULT1E1, PGR, CYP19A1
14idoxifene4410.5PGR, CYP19A1
15lapatinib44 49 1112.5ERBB3, PGR, CYP19A1
16hematoxylin4410.5ACTC1, INHA, DES, VIM
17b 7234410.5VIM, DES, ACTC1
18danazol44 11 2412.4GNRHR, GNRHR2, CYP19A1, PGR
1917beta-hydroxysteroid4410.4S100A6, CYP19A1, PGR, SULT1E1
20mifepristone44 59 28 1113.4OXTR, CYP19A1, PGR, SULT1E1
21progestins4410.4S100A6, CYP19A1, PGR, SULT1E1
22estrone sulfate44 2411.4CYP19A1, PGR, SULT1E1
23dihydrotestosterone44 28 11 2413.4PGR, CYP19A1, DES, GNRHR, VIM
24adriamycin4410.4MME, PGR, DES, VIM
25biotin44 11 2412.4VIM, DES, INHA, ACTC1
26steroidal4410.4OXTR, CYP19A1, PGR
27dexamethasone44 49 28 1113.3MME, OXTR
28indomethacin44 59 28 1113.3VIM, OXTR, CYP19A1, PGR, MME
29ribonucleic acid4410.3GNRHR, OXTR, INHA, PGR, MME, ACTC1
30formaldehyde44 2411.3VIM, DES, CYP19A1, ACTC1
31forskolin44 49 1112.2VIM, GNRHR, OXTR, INHA, MME, ERBB3
32adenylate4410.2VIM, GNRHR, DES, OXTR, PGR, MME
33megestrol44 1111.2CYP19A1, PGR
34diethylstilbestrol44 28 1112.2SULT1E1, PGR, CYP19A1
35doxorubicin44 49 1112.2VIM, GNRHR, DES, CYP19A1, PGR, MME
36acetaldehyde44 28 2412.1H2BFS, DES, VIM
37tamoxifen44 49 28 1113.1VIM, GNRHR, OXTR, CYP19A1, PGR, SULT1E1
38progestin4410.1VIM, S100A6, DES, OXTR, CYP19A1, PGR
39vegf4410.1VIM, DES, OXTR, PGR, MME, ACTC1
40arginine4410.1VIM, GNRHR, DES, OXTR, CYP19A1, MME
41genistein44 28 59 2 11 2415.0VIM, CYP19A1, PGR, SULT1E1, ERBB3
42gnrh4410.0VIM, GNRHR, GNRHR2, OXTR, CYP19A1, INHA
43paraffin4410.0VIM, S100A6, DES, INHA, PGR, MME
44retinoic acid44 2411.0VIM, S100A6, DES, CYP19A1, PGR, MME
45estradiol44 11 2411.9VIM, GNRHR, DES, OXTR, CYP19A1, INHA
46oligonucleotide449.9VIM, S100A6, GNRHR, OXTR, INHA, ERBB3
473beta-hydroxysteroid449.9PGR, INHA, CYP19A1
48steroid449.7S100A6, GNRHR, DES, OXTR, CYP19A1, INHA
49testosterone44 59 11 2412.6OXTR, DES, GNRHR, S100A6, VIM, CYP19A1
50progesterone44 59 28 11 2413.4ERBB3, VIM, SFRP4, S100A6, GNRHR, DES

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

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16Gene Ontology
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Cellular components related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ESC/E(Z) complexGO:03509810.2SUZ12, PHF1
2extracellular vesicular exosomeGO:0700629.9ACTC1, YWHAE, VIM

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.2ACTC1, DES, VIM

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gonadotropin-releasing hormone receptor activityGO:00496810.2GNRHR2, GNRHR

Products for genes affiliated with Endometrial Stromal Sarcoma

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  • Antibodies
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Sources for Endometrial Stromal Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet