ESS
MCID: END031
MIFTS: 54

Endometrial Stromal Sarcoma (ESS) malady

Rare diseases, Reproductive diseases, Cancer diseases categories
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Summaries for Endometrial Stromal Sarcoma

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Wikipedia:65 Endometrial stromal sarcoma is a malignant subtype of endometrial stromal tumor arising from the stroma... more...

MalaCards based summary: Endometrial Stromal Sarcoma, also known as undifferentiated endometrial sarcoma, is related to sarcoma and leiomyomatosis. An important gene associated with Endometrial Stromal Sarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoplasmic microtubules. The compounds toluidine and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and reproductive system.

Aliases & Classifications for Endometrial Stromal Sarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Endometrial Stromal Sarcoma, Aliases & Descriptions:

Name: Endometrial Stromal Sarcoma 8 42 10 48 62
Undifferentiated Endometrial Sarcoma 8 62
Ess 8 42
 
Endometrial Stromal Sarcoma, High Grade 8
Stromal Sarcoma of the Corpus Uteri 48
Sarcoma Endometrial Stromal 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:4226
NCIt39 C8973
MeSH34 D018203
SNOMED-CT57 70555003
MESH via Orphanet35 D018203
ICD10 via Orphanet26 C50
UMLS via Orphanet63 C0206630

Related Diseases for Endometrial Stromal Sarcoma

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Diseases related to Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.4DES, VIM, ACTC1
2leiomyomatosis31.1PGR
3adenofibroma31.1INHA
4uterine sarcoma31.0MME, DES
5lymphangioleiomyomatosis30.9PGR, DES
6hemangiopericytoma30.5DES, VIM, ACTC1
7leiomyoma30.4DES, PGR, VIM, MME, ACTC1
8smooth muscle tumor30.3DES, PGR, VIM, MME, ACTC1
9leiomyosarcoma30.3DES, INHA, PGR, VIM, ACTC1, MME
10breast cancer30.1INHA, SULT1E1, PGR, MME
11endometrial carcinoma30.0MME, PGR, SULT1E1
12adenocarcinoma29.5INHA, SULT1E1, PGR, VIM, MME, ACTC1
13endometriosis10.9
14empty sella syndrome10.6
15cellular leiomyoma10.6
16infantile myofibromatosis10.5DES
17uterine carcinosarcoma10.5
18cervical endometrial stromal sarcoma10.5
19uterine corpus endometrial stromal sarcoma10.5
20peritonitis10.5
21adenomyosis10.5
22fasciitis10.5ACTC1
23secretory meningioma10.4VIM
24adenomatoid tumor10.4VIM
25myoma10.4
26endometrial stromal nodule10.4
27intravenous leiomyomatosis10.4
28vaginal endometrial stromal sarcoma10.4
29cervicitis10.4
30endometrial stromal tumor10.4
31vaginitis10.4
32ductal carcinoma in situ10.3PGR
33desmoid tumor10.3ACTC1, DES
34cutaneous fibrous histiocytoma10.3ACTC1, DES
35embryonal rhabdomyosarcoma10.3ACTC1, DES
36mesenchymal chondrosarcoma10.3VIM, DES
37alveolar soft part sarcoma10.3DES, VIM
38cystadenoma10.2MME, INHA
39cervical cancer10.2
40renal cell carcinoma10.2
41ossifying fibromyxoid tumor10.2
42ovarian brenner tumor10.2
43portal vein thrombosis10.2
44intussusception10.2
45hydronephrosis10.2
46cerebritis10.2
47endometrial adenocarcinoma10.2
48intestinal obstruction10.2
49mediastinitis10.2
50pulmonary embolism10.2

Graphical network of the top 20 diseases related to Endometrial Stromal Sarcoma:



Diseases related to endometrial stromal sarcoma

Symptoms for Endometrial Stromal Sarcoma

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Drugs & Therapeutics for Endometrial Stromal Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Endometrial Stromal Sarcoma

Search NIH Clinical Center for Endometrial Stromal Sarcoma

Genetic Tests for Endometrial Stromal Sarcoma

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Anatomical Context for Endometrial Stromal Sarcoma

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MalaCards organs/tissues related to Endometrial Stromal Sarcoma:

32
Uterus, Smooth muscle, Breast, Lung, Colon, Ovary, Lymph node, Bone, Heart, Liver, Brain, Skeletal muscle, Placenta, Testes, Cervix, Monocytes

Animal Models for Endometrial Stromal Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Endometrial Stromal Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PGR, VIM, ACTC1
2MP:00053898.1VIM, PGR, SULT1E1, INHA
3MP:00053858.0DES, INHA, PGR, VIM, ACTC1
4MP:00053766.7ACTC1, MME, VIM, PGR, SULT1E1, INHA

Publications for Endometrial Stromal Sarcoma

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Articles related to Endometrial Stromal Sarcoma:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Fatal case of multiple recurrences of endometrial stromal sarcoma after fertility-sparing management. (25163509)
2014
2
Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors-molecular characterization shows genetic overlap with endometrial stromal sarcoma. (24285434)
2014
3
A very late recurrence of a formerly misdiagnosed low grade endometrial stromal sarcoma metastasized to the colon. (24240082)
2013
4
Extragenital endometrial stromal sarcoma arising in endometriosis. (22538201)
2012
5
A well circumscribed uterine endometrial stromal tumor with smooth muscle differentiation recurred as a low grade endometrial stromal sarcoma: is tumor margin enough for the diagnosis? (22524669)
2012
6
Cerebral metastases of an endometrial stromal sarcoma: report of the first case. (22868507)
2012
7
Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. (22982899)
2012
8
Tyrosine kinase receptor status in endometrial stromal sarcoma: an immunohistochemical and genetic-molecular analysis. (23018215)
2012
9
Endometrial stromal sarcoma in a 29-year-old patient. Case report and review of the literature. (22873114)
2012
10
High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis. (20730890)
2011
11
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
12
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases. (21652246)
2011
13
Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. (20354812)
2011
14
Endometrial stromal sarcoma from endometriosis. (20728821)
2010
15
Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma: three case reports. (21495227)
2010
16
Low-grade endometrial stromal sarcoma: a single center's experience with 22 cases. (18179547)
2008
17
Multilocular intrauterine cystic mass, atypical presentation of endometrial stromal sarcoma: a case report. (18040707)
2008
18
Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases. (19031927)
2008
19
Pulmonary metastases from endometrial stromal sarcoma may benefit from hormone therapy]. (17268368)
2007
20
Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. (17972504)
2007
21
Pathogenetic mechanisms in endometrial stromal sarcoma. (18000370)
2007
22
The cytogenetics and molecular biology of endometrial stromal sarcoma. (18000369)
2007
23
Sonographic findings of uterine endometrial stromal sarcoma. (17143032)
2006
24
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
25
Metastatic low-grade endometrial stromal sarcoma of the sigmoid colon three years after hysterectomy. (15818757)
2005
26
JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. (16049311)
2005
27
Pathologic quiz case: a 46-year-old woman with 1-day history of abdominal pain and intestinal obstruction. Extrauterine low-grade endometrial stromal sarcoma. (15679447)
2005
28
Endometrial stromal sarcoma--observational evidence of a genetic background? (15991528)
2005
29
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
30
Surgical cytoreduction and hormone therapy of an advanced endometrial stromal sarcoma of the ovary. (15121605)
2004
31
Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study. (14631363)
2004
32
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. (14751141)
2004
33
MIB1 as a possible predictor of recurrence in low-grade endometrial stromal sarcoma of the uterus. (12893199)
2003
34
Surgery and adjuvant radiation therapy of endometrial stromal sarcoma. (12407935)
2002
35
Polypoid uterine lesions mimicking endometrial stromal sarcoma. (10605413)
1999
36
Unilateral hydronephrosis and recurrent endometrial stromal sarcoma with review of the literature. (10443046)
1999
37
Endometrial stromal sarcoma involving the placenta. (9845753)
1998
38
A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). (9309124)
1997
39
Endometrial stromal sarcoma diagnosed by operative hysteroscopy. (9021394)
1996
40
Endometrial stromal sarcoma invading the bladder. (8221003)
1993
41
Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness. (1562530)
1992
42
Endometrial stromal sarcoma of the uterus. A clinical and histopathological study. The Radiumhemmet series 1936-1981. (2335259)
1990
43
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
44
Chronic obstruction of the inferior vena cava with recurrent endometrial stromal sarcoma. (2429400)
1986
45
Hemangiopericytoma of the uterus vs. hemangiopericytoma-like endometrial stromal sarcoma: a histopathological approach to differential diagnosis. (4054418)
1985
46
Ultrastructure of endometrial stromal sarcoma. (1111916)
1975
47
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
48
Fine structure of endometrial stromal sarcoma. (4920397)
1970
49
Endometrial stromal sarcoma. (5729399)
1968
50
Endometrial stromal sarcoma. (13999681)
1963

Variations for Endometrial Stromal Sarcoma

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Expression for genes affiliated with Endometrial Stromal Sarcoma

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Expression patterns in normal tissues for genes affiliated with Endometrial Stromal Sarcoma

Search GEO for disease gene expression data for Endometrial Stromal Sarcoma.

Pathways for genes affiliated with Endometrial Stromal Sarcoma

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Pathways related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.6VIM, DES
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.6VIM, DES
3
Show member pathways
9.5MME, INHA
49.4INHA, PGR
59.2ACTC1, VIM, DES
6
Show member pathways
9.2ACTC1, VIM, DES

Compounds for genes affiliated with Endometrial Stromal Sarcoma

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Compounds related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1toluidine449.9VIM, DES
22-methoxyethanol449.9VIM, ACTC1
3phalloidin449.8DES, VIM
4gemfibrozil28 44 1111.8DES, VIM
5actomyosin449.7VIM, ACTC1
6orcein449.6DES, ACTC1, VIM
7s 100449.6ACTC1, VIM, DES
8reticulin449.6ACTC1, VIM, DES
9mucicarmine449.6VIM, DES, ACTC1
10b 723449.6ACTC1, DES, VIM
11procollagen449.6DES, ACTC1, VIM
12formaldehyde44 2410.5ACTC1, DES, VIM
13bezafibrate44 28 1111.5VIM, DES
14bromodeoxyuridine449.4VIM, MME, DES
15leupeptin449.4MME, VIM
16nomegestrol acetate449.4PGR, SULT1E1
1712-o-tetradecanoylphorbol 13-acetate449.4VIM, DES, MME
18tibolone449.3SULT1E1, PGR
19matrigel449.3ACTC1, VIM, MME
20dihydrotestosterone44 28 24 1112.3PGR, DES, VIM
21methionine449.3VIM, MME, DES
22glycogen44 2410.3ACTC1, VIM, DES
23acetylcholine44 50 28 24 1113.3VIM, MME, DES
24estrone sulfate44 2410.2SULT1E1, PGR
25hematoxylin449.2INHA, ACTC1, VIM, DES
26biotin44 24 1111.1ACTC1, INHA, VIM, DES
27vitamin a44 24 1111.1PGR, MME, VIM
28actinomycin d449.1MME, DES, VIM
29heparan sulfate44 2410.1VIM, SULT1E1, DES
30indomethacin44 28 61 1112.1VIM, PGR, MME
31creatinine449.0DES, VIM, MME, ACTC1
32forskolin44 50 1111.0MME, VIM, INHA
33ribonucleic acid448.9ACTC1, MME, INHA, PGR
34adriamycin448.9DES, PGR, MME, VIM
35doxorubicin44 50 1110.8VIM, MME, PGR, DES
36adenylate448.8VIM, PGR, MME, DES
37tamoxifen44 50 28 1111.8SULT1E1, VIM, PGR
38gnrh448.8PGR, MME, INHA, VIM
39dexamethasone44 50 28 1111.8ACTC1, PGR, MME, VIM
40cysteine448.7PGR, MME, VIM, DES
41progestin448.6SULT1E1, PGR, VIM, DES
42vegf448.4DES, ACTC1, MME, VIM, PGR
43retinoic acid44 249.4MME, DES, PGR, VIM, ACTC1
44genistein44 28 61 2 24 1113.2SULT1E1, PGR, VIM
45estradiol44 24 1110.1PGR, SULT1E1, INHA, DES, VIM
46paraffin448.0PGR, VIM, MME, INHA, DES, ACTC1
47steroid447.7INHA, DES, SULT1E1, PGR, MME, ACTC1
48progesterone44 28 61 24 1111.2MME, ACTC1, VIM, PGR, SULT1E1, INHA
49testosterone44 61 24 1110.2MME, INHA, ACTC1, VIM, PGR, DES
50estrogen447.2MME, DES, INHA, SULT1E1, PGR, VIM

GO Terms for genes affiliated with Endometrial Stromal Sarcoma

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Cellular components related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.6VIM, DES

Biological processes related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.2ACTC1, VIM, DES

Molecular functions related to Endometrial Stromal Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.6VIM, DES
2steroid bindingGO:0054968.7PGR, SULT1E1

Products for genes affiliated with Endometrial Stromal Sarcoma

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Sources for Endometrial Stromal Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet