MCID: END044
MIFTS: 69

Endometriosis malady

Reproductive diseases category

Summaries for Endometriosis

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Endometriosis is a problem affecting a woman's uterus - the place where a baby grows when she's pregnant. endometriosis is when the kind of tissue that normally lines the uterus grows somewhere else. it can grow on the ovaries, behind the uterus or on the bowels or bladder. rarely, it grows in other parts of the body. this "misplaced" tissue can cause pain, infertility, and very heavy periods. the pain is usually in the abdomen, lower back or pelvic areas. some women have no symptoms at all. having trouble getting pregnant may be the first sign. the cause of endometriosis is not known. pain medicines and hormones often help. severe cases may need surgery. there are also treatments to improve fertility in women with endometriosis.

MalaCards: Endometriosis, also known as endometriosis, site unspecified, is related to peritonitis and infertility. An important gene associated with Endometriosis is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Estrogen metabolism and Glucuronidation. The drugs danazol and ethynodiol diacetate and the compounds estradiol and progesterone have been mentioned in the context of this disorder. Affiliated tissues include endothelial, uterus and ovary, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Wikipedia:63 Endometriosis is a gynecological condition in which cells from the lining of the uterus (endometrium)... more...

Aliases & Classifications for Endometriosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

endometriosis 8 10 44 33
endometriosis, site unspecified 60


External Ids:

Disease Ontology8 DOID:289
MeSH34 D004715
ICD9CM27 617, 617.9
NCIt39 C3014
ICD1025 N80, N80.9

Related Diseases for Endometriosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Endometriosis family:

Endometriosis 1 Rare Endometriosis

Diseases related to Endometriosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.4MUC16
2infertility31.2CYP19A1, ESR2, GNRH1, CYP1A1, FST, IL11
3adenocarcinoma30.9CYP1A1, HNF1B, HGF, ARSH, CYP1B1, STS
4ovarian cancer30.7PGR, ESR2, FST, MUC16, VEGFA, STS
5endometrial stromal sarcoma30.7PGR, CYP19A1, ESR2
6leiomyoma30.5GNRH1, PGR, CYP19A1, ESR2, STS
7endometrial carcinoma30.3PGR, ESR2, MUC16
8ovarian cyst30.3CYP19A1, MUC16, ESR2, GNRH1
9myoma30.3CYP19A1, GNRH1, PGR
10adenofibroma30.2MUC16
11breast cancer30.2STS, ESR2, CYP19A1, PGR, CYP1A1
12ovarian disease30.2MUC16, CYP19A1, GNRH1
13uterine fibroid30.1STS, PGR, CYP19A1, ESR2, MUC16, GNRH1
14adenoma30.1CYP1B1, FST, GNRH1, ESR2, CYP1A1
15colon adenocarcinoma30.1ESR2
16papillary carcinoma30.0PGR, HGF, MUC16
17hepatitis30.0HGF
18prostate cancer29.9ESR2, STS, VEGFA, HNF1B, CYP1A1, CYP19A1
19leukemia29.9FST, CYP1A1, CYP1B1, ESR2, IL11
20atherosclerosis29.9ESR2, FST, CYP1A1
21cervical cancer29.9CYP1A1, MUC16
22colorectal cancer29.7MUC16, CYP1A1, ESR2, CYP1B1, HGF, VEGFA
23lung cancer29.7CYP1A1, CYP1B1, MUC16, VEGFA, HGF, ESR2
24choriocarcinoma29.7STS, GNRH1, CYP19A1, FST, ESR2
25melanoma29.7HGF, FST, CYP1B1, CYP1A1, VEGFA
26leiomyosarcoma29.7PGR, MUC16
27malignant mesothelioma29.7HGF, MUC16
28estrogen excess29.7CYP19A1, PGR
29uterine disease29.7HNF1B, CYP19A1
30ovarian serous cystadenocarcinoma29.7MUC16
31cystadenocarcinoma29.7MUC16
32ovarian endometriosis11.0
33endometriosis of ovary10.6
34sarcoma10.5
35clear cell adenocarcinoma10.5
36pneumothorax10.5
37rare endometriosis10.5
38adenosarcoma10.4
39endometriosis of uterus10.4
40vaginitis10.4
41endometriosis of intestine10.4
42cervix endometriosis10.3
43fallopian tube endometriosis10.3
44cervicitis10.3
45intestinal obstruction10.3
46leiomyomatosis10.3
47pelvic inflammatory disease10.2
48salpingitis10.2
49ureteral obstruction10.2
50cystadenoma10.1

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to endometriosis

Clinical Features for Endometriosis

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Drugs & Therapeutics for Endometriosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endometriosis

Drug clinical trials:

Search ClinicalTrials for Endometriosis

Search NIH Clinical Center for Endometriosis

Search CenterWatch for Endometriosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Endometriosis

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Anatomical Context for Endometriosis

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32MalaCards
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MalaCards organs/tissues related to Endometriosis:

32
Endothelial, Uterus, Ovary, Monocytes, Colon, Testes, T cells, Cervix, Appendix, Liver, Breast, Pituitary, Lymph node, Lung, Kidney, Bone, Smooth muscle, Thyroid, Prostate, Small intestine, Cortex, Skeletal muscle, Testis, Eye

Animal Models for Endometriosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endometriosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537011.7ESR2, HNF1B, HGF, GNRH1, VEGFA, CYP1A1
2MP:000539711.6RXFP1, GNRH1, VEGFA, CYP1A1, CYP19A1, PGR
3MP:000539011.4RXFP1, GNRH1, VEGFA, CYP19A1, PGR, FST
4MP:000537611.3HNF1B, GNRH1, CYP1B1, PGR, FST, SERPINA6
5MP:000537911.1HNF1B, RXFP1, FST, ESR2
6MP:001077110.7RXFP1, GNRH1, VEGFA, FST

Publications for Endometriosis

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Sources:
50PubMed
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Articles related to Endometriosis:

(show top 50)    (show all 2146)
idTitleAuthorsYear
1
Extra-genital endometriosis. (24401195)
2014
2
ESHRE guideline: management of women with endometriosis. (24435778)
2014
3
Endometriosis in a mesothelial cyst of tunica vaginalis of the testis. Report of a case. (23964911)
2013
4
The influence of endometriosis-related symptoms on work life and work ability: a study of Danish endometriosis patients in employment. (23537616)
2013
5
17I^-Estradiol and steady-state concentrations of H2O2: antiapoptotic effect in endometrial cells from patients with endometriosis. (23416363)
2013
6
Regional treatment with liquid barrier agents: a novel therapeutic option for intraperitoneal endometriosis? (23517566)
2013
7
Diagnostic value of the neutrophil-to-lymphocyte ratio and the combination of serum CA-125 for stages III and IV endometriosis. (23769549)
2013
8
Fertility preservation options in women with endometriosis. (23598777)
2013
9
BMPR1B Up-Regulation via a miRNA Binding Site Variation Defines Endometriosis Susceptibility and CA125 Levels. (24339876)
2013
10
The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis. (23770466)
2013
11
Relationship of polymorphisms of AhR -1661G/A with GSTP1 -313A/G and susceptibility to endometriosis]. (23141164)
2012
12
A potential link of oxidative stress and cell cycle regulation for development of endometriosis. (22591187)
2012
13
Matrix metalloproteinase-3 mRNA: a promising peripheral blood marker for diagnosis of endometriosis. (21150162)
2011
14
Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis. (21289256)
2011
15
RsaI polymorphism of the ERI^ gene in women with endometriosis. (21476192)
2011
16
Intercellular adhesion molecule-1 and interleukin-6 gene polymorphisms in patients with advanced-stage endometriosis. (20160446)
2010
17
Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. (19095810)
2009
18
Risk factors for deep endometriosis: a comparison with pelvic and ovarian endometriosis. (18023442)
2008
19
Decreased expression of angiogenin in the eutopic endometrium from women with advanced stage endometriosis. (18955785)
2008
20
Decreased anti-MA1llerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis. (17624337)
2008
21
Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis. (18650217)
2008
22
The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis. (18069114)
2008
23
Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems. (17609243)
2007
24
High-grade endometrial stromal sarcoma arising from colon endometriosis. (17262201)
2007
25
Follicular fluid vascular endothelial growth factor and tumour necrosis factor alpha concentrations in patients with endometriosis undergoing ICSI. (17854531)
2007
26
Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis. (17997746)
2007
27
Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population. (17852426)
2007
28
Utero-tubal sperm transport and its impairment in endometriosis and adenomyosis. (17344532)
2007
29
Elevated interleukin-16 levels in the peritoneal fluid of women with endometriosis may be a mechanism for inflammatory reactions associated with endometriosis. (15820794)
2005
30
Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder. (15236995)
2004
31
Aromatase and endometriosis. (15083380)
2004
32
Analysis of the clonality of ectopic glands in peritoneal endometriosis using laser microdissection. (14607565)
2003
33
Biological aspects of endometriosis in vitro fertilization]. (14968070)
2003
34
Endometrial adenocarcinoma arising from endometriosis of the rectosigmoid colon. (12144831)
2002
35
Regulation and modulation of abnormal immune responses in endometriosis. (11949945)
2002
36
A modified baboon model for endometriosis. (11949957)
2002
37
Catechol-O-methyltransferase polymorphism and endometriosis. (12168735)
2002
38
Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis. (12372448)
2002
39
Studies on the human leukocyte antigen-DR in patients with endometriosis: genotyping of HLA-DRB1 alleles. (11870103)
2002
40
GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer. (11159742)
2001
41
Correlation of the metabolism of oxygen free radical in ovary, uterine muscle and vein blood with the pathogenesis of endometriosis or endometrioma]. (11783383)
2001
42
Decreased expression of the decoy interleukin-1 receptor type II in human endometriosis. (11159185)
2001
43
Correlation between decreased type-II interleukin-1 receptor and increased monocyte chemotactic protein-1 expression in the endometrium of women with endometriosis. (11327545)
2001
44
Expression of CA125 in thoracic endometriosis in a patient with catamenial pneumothorax. (10516547)
1999
45
Tenascin is differentially expressed in endometrium and endometriosis. (10365101)
1999
46
Fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis and in endometrium and peritoneal fluid from healthy women. (9806560)
1998
47
Prevalence of ovarian endometriosis in epithelial ovarian cancer. (9486515)
1997
48
Endometriosis associated with the N314D mutation of galactose-1-phosphate uridyl transferase (GALT). (9238674)
1996
49
Sciatic endometriosis: a treatable sensorimotor mononeuropathy. (3762945)
1986
50
Clinicopathologic investigation of ovarian endometriosis: a comparative study of cystic and non-cystic types. (4039743)
1985

Genetic Variations for Endometriosis

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Expression for genes affiliated with Endometriosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endometriosis

Search GEO for disease gene expression data for Endometriosis.

Pathways for genes affiliated with Endometriosis

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Endometriosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Endometriosis according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2414.9ESR2, CYP1A1, MUC16, STS, ARSH, GNRH1
2progesterone44 59 28 11 2416.8CYP1B1, PGR, IL11, FST, SERPINA6, ESR2
3testosterone44 59 11 2415.8HSD17B1, HGF, GNRH1, ARSH, STS, MUC16
4steroid4412.6IL11, CYP1B1, CYP19A1, MUC16, STS, ARSH
5retinoic acid44 2413.5ESR2, HNF1B, HGF, GNRH1, IL11, STS
6estrone44 28 11 2415.4PGR, CYP1B1, CYP19A1, CYP1A1, ARSH, GNRH1
7tamoxifen44 49 28 1115.3VEGFA, CYP1B1, CYP19A1, CYP1A1, SERPINA6, STS
8dihydrotestosterone44 28 11 2415.2HSD17B1, GNRH1, ARSH, STS, CYP19A1, SERPINA6
9doxorubicin44 49 1114.0VEGFA, MUC16, CYP19A1, CYP1B1, PGR, IL11
10genistein44 28 59 2 11 2417.0VEGFA, PGR, CYP1B1, CYP19A1, CYP1A1, HGF
11adenylate4411.9SERPINA6, GNRH1, HGF, ESR2, RXFP1, FST
12steroidal4411.9GNRH1, ESR2, SERPINA6, PGR, CYP19A1, ARSH
1317beta-hydroxysteroid4411.9HSD17B1, STS, CYP19A1, CYP1B1, PGR, ESR2
14dexamethasone44 49 28 1114.9VEGFA, MUC16, CYP1A1, FST, GNRH1, HGF
15progestins4411.9ESR2, PGR, GNRH1, ARSH, STS, CYP19A1
164-hydroxytamoxifen4411.9CYP1B1, CYP19A1, CYP1A1, STS, ESR2, ARSH
17androstenedione44 2412.9ESR2, GNRH1, SERPINA6, CYP1A1, CYP19A1, CYP1B1
18progestin4411.9GNRH1, ARSH, STS, VEGFA, CYP19A1, PGR
19cyclophosphamide44 49 1113.9IL11, HGF, PGR, CYP1B1, CYP19A1, CYP1A1
20paclitaxel44 49 1113.9CYP19A1, CYP1B1, VEGFA, PGR, IL11, HGF
21mifepristone44 59 28 1114.7CYP19A1, VEGFA, PGR, SERPINA6, ESR2, GNRH1
22toremifene44 1112.6CYP19A1, ESR2, GNRH1, CYP1A1, PGR
23tibolone4411.6STS, ARSH, PGR, GNRH1, CYP19A1
24danazol44 11 2413.6PGR, CYP19A1, STS, ARSH, GNRH1
25letrozole44 49 59 1114.6PGR, ESR2, CYP1B1, CYP19A1, STS
26dmso4411.6GNRH1, ESR2, PGR, HGF, CYP1B1, CYP1A1
27flutamide44 59 1113.6GNRH1, CYP1A1, CYP19A1, CYP1B1, PGR
28estrone sulfate44 2412.6ARSH, STS, PGR, CYP1B1, CYP19A1
295fluorouracil4411.5PGR, HGF, IL11, GNRH1, CYP1B1
30diethylstilbestrol44 28 1113.5PGR, ESR2, FST, GNRH1, CYP19A1
31dhea4411.5CYP19A1, ARSH, STS, SERPINA6, ESR2
32gnrh4411.4ESR2, FST, PGR, CYP19A1, ARSH, GNRH1
33gefitinib44 49 1113.4HGF, VEGFA, CYP1A1, CYP19A1, ESR2
34nandrolone44 2412.4ESR2, CYP19A1, PGR, SERPINA6
35estradiol benzoate4411.4GNRH1, ESR2, PGR, CYP19A1
36dehydroepiandrosterone sulfate4411.4STS, SERPINA6, CYP19A1, GNRH1
37leuprolide acetate4411.4GNRH1, CYP19A1, PGR, ESR2
38exemestane49 44 59 1114.3ESR2, PGR, CYP19A1, CYP1B1
39ribonucleic acid4411.3ESR2, SERPINA6, FST, IL11, PGR, GNRH1
40bisphenol a4411.3PGR, ESR2, CYP19A1, ARSH
41clomiphene citrate4411.3ESR2, GNRH1, PGR, CYP19A1
42fulvestrant44 49 28 1114.3ESR2, CYP1A1, PGR, CYP19A1
43cyproteroneacetate4411.2PGR, GNRH1, SERPINA6, CYP19A1
44levonorgestrel44 59 28 1114.1SERPINA6, CYP19A1, PGR, ESR2
45norelgestromin44 1112.1STS, PGR, ARSH
46estrogen4411.1ARSH
4717-hydroxyprogesterone44 2412.0SERPINA6, CYP19A1, MUC16, GNRH1
48cycloheximide4411.0HGF
49dydrogesterone28 44 1112.8STS, PGR, ARSH
50promegestone44 2811.6PGR, STS, ARSH

GO Terms for genes affiliated with Endometriosis

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16Gene Ontology
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Cellular components related to Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3SERPINA6, IL11, MUC16, VEGFA, GNRH1, HGF

Biological processes related to Endometriosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:00820211.1CYP1B1, CYP19A1, HSD17B1
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0IL11, VEGFA, HGF
3cell-cell signalingGO:00726710.9GNRH1, PGR, IL11, ESR2
4omega-hydroxylase P450 pathwayGO:09726710.8CYP1A1, CYP1B1
5estrogen biosynthetic processGO:00670310.8HSD17B1, CYP19A1
6sterol metabolic processGO:01612510.8CYP1B1, CYP19A1
7epoxygenase P450 pathwayGO:01937310.5CYP1B1, CYP1A1

Molecular functions related to Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aromatase activityGO:07033010.9CYP1B1, CYP19A1, CYP1A1
2steroid bindingGO:00549610.8PGR, SERPINA6, ESR2
3oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.8CYP1B1, CYP19A1
4oxygen bindingGO:01982510.6CYP1B1, CYP19A1, CYP1A1

Products for genes affiliated with Endometriosis

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  • Antibodies
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Sources for Endometriosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet