Search MalaCards:
MCID: END044

Endometriosis malady
12 drugs, 497 genes, 14 tissues, 979 related diseases, 29 phenotypes, 1064 articles, clinical trials.

Summaries for Endometriosis

about this section
Sources:
23MedlinePlus, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
MedlinePlus: Endometriosis is a problem affecting a woman's uterus - the place where a baby grows when she's pregnant. endometriosis is when the kind of tissue that normally lines the uterus grows somewhere else. it can grow on the ovaries, behind the uterus or on the bowels or bladder. rarely, it grows in other parts of the body. this "misplaced" tissue can cause pain, infertility, and very heavy periods. the pain is usually in the abdomen, lower back or pelvic areas. some women have no symptoms at all. having trouble getting pregnant may be the first sign. the cause of endometriosis is not known. pain medicines and hormones often help. severe cases may need surgery. there are also treatments to improve fertility in women with endometriosis.23

MalaCards: Endometriosis, also known as endometriosis, site unspecified, is related to carcinoma and prostatitis. An important gene associated with Endometriosis is ENDO1 (Endometriosis, susceptibility to, 1), and among its related pathways are p38 Signaling and Cytokine-cytokine receptor interaction. The drugs danazol and hydroxyprogesterone caproate and the compounds estradiol and oxygen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, smooth muscle and colon, and related mouse phenotypes are mortality/aging and muscle.

Wikipedia: Endometriosis is a gynecological medical condition in which cells from the lining of the uterus...44 more...

Aliases & Descriptions for Endometriosis

about this section
Sources:
6Disease Ontology, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM, 27NCIt
See all sources

Aliases & Descriptions:

endometriosis 6 8 32 23
endometriosis, site unspecified 43

Related Diseases for Endometriosis

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Disease types for endometriosis family:

endometriosis 1

Diseases related to endometriosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 975)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma62.8PIK3CA, KLF9, NCOA1, NCOR1, NCOR2, RELA
2prostatitis53.1PIK3CA, PIBF1, NCOA1, NCOR1, NCOR2, RELA
3adenocarcinoma52.6PIK3CA, KLF9, NCOA1, RELA, KITLG, VTN
4ovarian cancer51.9PIK3CA, NCOA1, NCOR1, NCOR2, RELA, KITLG
5leukemia49.8PIK3CA, PIBF1, KLF9, NCOA1, NCOR1, NCOR2
6peritonitis49.5PIBF1, RELA, CNTF, KIR2DL1, KIR2DL3, KITLG
7infertility48.3KIR2DL1, KIR2DL3, KITLG, PCSK5, GC, SEMA3C
8ovarian endometriosis46.6NCOA1, NCOR1, NCOR2, SERPINA6, BSG, VEGFA
9neuronitis45.3PIK3CA, NCOA1, NCOR1, NCOR2, RELA, CNTF
10ovarian carcinoma42.9PIK3CA, RELA, VTN, PCNA, SERPINB2, SERPINE1
11atherosclerosis40.7VTN, PCNA, PCSK5, SERPINC1, SERPINF1, SERPINB2
12adenomyosis40.2KIR2DL3, KIR3DL1, PCNA, VEGFA, LIF, BCL2
13endometrial carcinoma39.7PIK3CA, KLF9, NCOA1, NCOR1, NCOR2, RELA
14adenoma39.4PIK3CA, NCOA1, NCOR1, NCOR2, CNTF, KITLG
15cholesterol38.6PIK3CA, KLF9, NCOA1, NCOR1, NCOR2, RELA
16leiomyoma38.3KLF9, PCNA, SERPINB3, SERPINE1, VIM, BSG
17hypoxia37.2PIK3CA, NCOA1, RELA, KITLG, VTN, PCNA
18sarcoma36.9PIK3CA, NCOA1, RELA, KITLG, VTN, SFRP4
19endometrial adenocarcinoma34.5PIK3CA, KLF9, VTN, PCNA, SERPINB2, VIM
20vaginitis33.9GC, SERPINC1, SERPINA6, SERPINE1, VIM, VIP
21immunodeficiency32.8KIR3DL1, VIP, BMP6, S100A12, MRPL28, CD79A
22uterine fibroid32.6PCNA, BSG, LEPR, MUC16, CDH2, FGF1
23spontaneous abortion32.3PIBF1, KIR2DL1, KIR2DL3, KIR3DS1, KIR3DL1, SERPINC1
24anemia31.9NCOR1, RELA, KITLG, PCNA, SERPINC1, BRCA1
25cystadenocarcinoma31.7PCNA, VIM, VEGFA, BIRC5, BCL2, MUC1
26cystadenoma31.1PCNA, VIM, BRAF, BRCA1, VEGFA, VEGFC
27breast cancer30.8PIK3CA, NCOA1, BRCA1, BRCA2, BMP6, PAK1
28pneumothorax30.5KDR, MUC1, MUC16, CD36, CCL11, GNRH1
29serous cystadenocarcinoma30.0VEGFA, BIRC5, BCL2, MUC16, BAX, CDKN1A
30benign tumors30.0PCNA, VIM, BSG, MUC1, MUC16, MST1R
31endometritis29.9VEGFA, PAEP, MTOR, CGA, CFL1, CDKN2A
32clear cell adenocarcinoma29.8PIK3CA, BRCA1, VEGFA, BIRC5, MUC16, MTOR
33endocervicitis29.8VIM, BCL2, MUC1, MUC16, CDKN1A, CDKN2A
34ovarian serous cystadenocarcinoma29.8VEGFA, BIRC5, BCL2, MUC16, BAX, FAS
35ovarian clear cell adenocarcinoma29.7PIK3CA, VEGFA, MUC16, MTOR, CDH1, INHBA
36hepatitis29.5XDH, IL2RB, FASLG, FAS, IFNA2, F2
37ureteral obstruction29.4SFRP4, BMP6, MPO, CDKN1A, CD36, CDH1
38aplastic anemia29.3KITLG, GSTM1, GSTT1, IL11, FASLG, FAS
39hyperprolactinemia29.1VIP, BRD2, BGLAP, CGA, IL13, IL2RB
40was-related disorders27.3BRAF, VDR, PARK7, LEP, CHGA, XDH
41wilms tumor26.0PCNA, SERPINF1, VIM, BRCA1, BRCA2, VEGFA
42pancreatitis25.7PIK3CA, RELA, KITLG, VTN, SFRP4, PCNA
43gonococcal synovitis25.4PIK3CA, NCOA1, RELA, CNTF, KITLG, KIR3DL1
44thyroiditis24.9PIK3CA, KLF9, NCOA1, NCOR1, NCOR2, RELA
45melanoma24.3PIK3CA, RELA, CNTF, KIR2DL1, KIR2DL3, KITLG
46hepatocellular carcinoma24.0PIK3CA, RELA, KIR3DS1, KIR3DL1, VTN, SFRP4
47breast carcinoma23.5PIK3CA, NCOR1, KITLG, VTN, SFRP4, PCNA
48gastric cancer22.8PIK3CA, RELA, VTN, PCNA, SERPINB2, SERPINE1
49esophagitis21.5PIK3CA, RELA, KITLG, SFRP4, PCNA, PCDH17
50asthma21.2PIK3CA, KITLG, VTN, PCNA, GC, SERPINB3

Graphical network of the top 20 diseases related to endometriosis:



Graphical network of diseases related to endometriosis

Clinical Features for Endometriosis

about this section

Drugs & Therapeutics for Endometriosis

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for endometriosis

Drug clinical trials:

Search ClinicalTrials for endometriosis

Search NIH Clinical Center for endometriosis

Search CenterWatch for endometriosis

Inferred drug relations via UMLS/NDF-RT:

43 28 danazol, desogestrel, ethynodiol diacetate, goserelin acetate, hydroxyprogesterone, hydroxyprogesterone caproate, leuprolide, leuprolide acetate, nafarelin, nafarelin acetate, norethindrone, norethindrone acetate

Genetic Tests for Endometriosis

about this section

Anatomical Context for Endometriosis

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to endometriosis:

22
Lymph node, Smooth muscle, Colon, Liver, Lung, Breast, Ovary, Uterus, Prostate, Monocytes, T cells, B cells, Endothelial, Pituitary

Phenotypes for genes affiliated with Endometriosis

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to endometriosis:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1mortality/agingMP:0010768INFPIK3CA, NCOR1, NCOR2, RELA, KITLG, SFRP4
2muscle phenotypeMP:0005369INFPIK3CA, NCOR1, RELA, CNTF, SERPINB2, VIM
3hematopoietic system phenotypeMP:0005397INFCNTF, PCNA, SERPINB2, BRAF, BRCA1, BRCA2
4growth/size phenotypeMP:0005378INFPIK3CA, NCOA1, NCOR1, NCOR2, RELA, KITLG
5cellular phenotypeMP:0005384INFPIK3CA, NCOR1, NCOR2, RELA, CNTF, KITLG
6homeostasis/metabolism phenotypeMP:000537619.1PIK3CA, NCOA1, NCOR1, NCOR2, RELA, CNTF
7reproductive system phenotypeMP:000538915.6PIK3CA, NCOA1, SFRP4, SERPINF1, VIP, NAT1
8vision/eye phenotypeMP:000539113.5PIK3CA, RELA, KITLG, SERPINC1, SERPINF1, VIM
9endocrine/exocrine gland phenotypeMP:000537913.4NCOA1, BRCA1, BRCA2, BRD2, LHB, UCN3
10no phenotypic analysisMP:000301213.0PCNA, PCSK5, SERPINA6, VEGFA, VCAM1, CLOCK
11skeleton phenotypeMP:000539012.9NCOA1, RELA, KITLG, PCSK5, GC, BRAF
12renal/urinary system phenotypeMP:000536712.9NCOA1, SFRP4, PCSK5, SERPINA6, BRAF, BRCA1
13respiratory system phenotypeMP:000538812.0SFRP4, PCSK5, BRCA1, LIF, LEFTY2, LEPR
14liver/biliary system phenotypeMP:000537012.0NCOR1, NCOR2, SERPINC1, SERPINA6, BRD2, VEGFA
15other phenotypeMP:000539511.9KDR, LEPR, LAMC1, FSHR, CDKN2A, CD40LG
16craniofacial phenotypeMP:000538211.5NCOR2, KITLG, PCSK5, BNC2, XRCC4, L1CAM
17limbs/digits/tail phenotypeMP:000537111.2RELA, KITLG, PCSK5, BRCA1, BRCA2, VEGFA
18hearing/vestibular/ear phenotypeMP:00053779.5KITLG, VDR, BCL2, CHUK, UCN, BAX
19embryogenesis phenotypeMP:0005380INFPIK3CA, NCOA1, NCOR1, SEMA3C, SERPINC1, VIM
20immune system phenotypeMP:0005387INFNCOA1, NCOR1, CNTF, PCSK5, SERPINA6, SERPINB2
21nervous system phenotypeMP:0003631INFNCOA1, NCOR1, RELA, CNTF, KITLG, PCSK5
22normal phenotypeMP:0002873INFRELA, VTN, VIP, NAT1, BRAF, BRCA1
23cardiovascular system phenotypeMP:0005385INFPIK3CA, NCOR2, RELA, KITLG, SFRP4, PCSK5
24behavior/neurological phenotypeMP:0005386INFPIK3CA, KLF9, NCOA1, NCOR1, NCOR2, CNTF
25adipose tissue phenotypeMP:0005375INFPIK3CA, NCOR1, NCOR2, SERPINE1, BRAF, BRCA1
26tumorigenesisMP:0002006INFPIK3CA, KITLG, SERPINE1, BRAF, BRCA1, BRCA2
27integument phenotypeMP:0010771INFNCOA1, NCOR1, RELA, KITLG, BRAF, BRCA1
28pigmentation phenotypeMP:0001186INFKITLG, SEMA3C, SERPINC1, SERPINF1, BRAF, BRCA1
29digestive/alimentary phenotypeMP:0005381INFNCOR2, KITLG, SFRP4, PCSK5, SERPINF1, BRAF

Publications for genes affiliated with Endometriosis

about this section
Sources:
35PubMed
See all sources

Articles related to endometriosis:

(show top 50)    (show all 1064)
idTitleAuthorsYearAffiliating Genes
1Single-nucleotide polymorphisms in the lysyl oxidase- like protein 4 and complement component 3 genes are associated with increased r isk for endometriosis and endometriosis-associated infertility. (21733505)Ruiz L.A.... Flores I.2011C3, LOXL4
2MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility. (21349170)Chang C.Y.... Tsai F.J.2011MUC4
3Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. (20797713)Sundqvist J.... D'Hooghe T.M.2011C5, CD40, CCL21
4Association of Interleukin-10 Promoter Polymorphism a nd Endometriosis. (20618176)Riiskjaer M.... Kruse C.2010IL10
5Polymorphism in Vitamin D-Binding Protein as a Geneti c Risk Factor in the Pathogenesis of Endometriosis. (20980430)Faserl K.... Seeber B.2010VDR
6Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis. (20100617)Saare M.... Salumets A.2010MMP2, MMP9
7Electrodermal measures of Jing-Well points and their clinical relevance in endometriosis-related chronic pelvic pain. (19958132)Ahn A.C.... Wayne P.M.2009IL6
8Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans. (18722604)Banu S.K.... Arosh J.A.2009PTGS2, PCNA, PTGER4
9Effects and safety of gonadotrophin-releasing hormon e agonist combined with estradiol patch and oral medroxyprogesterone acetate on endometriosis (19957549)Wang Y.Q.... Hu W.G.2009BGLAP
10Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis. (18485158)Nawathe A.... Khan K.S.2008CYP19A1
11Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis. (18555226)Cho S.... Lee B.S.2008MUC16
12Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. (18595729)Umezawa M.... Sugamata M.2008IL2, CCR1
13Progesterone receptor +331G/A polymorphism in endometriosis and deep-infiltrating endometriosis. (18281038)Gentilini D.... Di Blasio A.M.2008PGR
14Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis. (19055724)Honda H.... Morin P.J.2008SHC1, AXL
15Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis. (18584412)Salata I.M.... LewiA8ski A.2008MMP2
16MMAC tumor supressor gene expression in ovarian endometriosis and ovarian adenocarcinoma. (17713092)Cirpan T.... Sagol S.2007PTEN, MUC16
17Inflammatory markers in endometriosis: reduced peritoneal neutrophil response in minimal endometriosis. (17611835)Riley C.F.... Videm V.2007LTF
18Immunohistochemical study of osteopontin and L-selectin in a rat endometriosis model and in human endometriosis. (17482182)Odagiri K.... Suzuki M.2007SPP1, CD44
19Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis. (16810057)Ali-Fehmi R.... Munkarah A.R.2006PTEN
20Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls. (16750201)Zhang H.... Cui H.2006VIM
21Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary. (16258507)Kato N.... Motoyama T.2006HNF1B
22No association between HLA-DRB1 alleles and susceptibility to advanced stage endometriosis in a Korean population. (16155070)Whang D.H.... Kim Y.B.2006HLA-DRB1
23Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis. (16880228)Collette T.... Akoum A.2006MMP9, TIMP1
24Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. (16456945)Chou Y.C.... Yuan C.C.2006PTGS2, KRT7, KRT20
25Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. (16045534)Zhang X.... Deng L.2005IL17A
26Elevated interleukin-16 levels in the peritoneal fluid of women with endometriosis may be a mechanism for inflammatory reactions associated with endometriosis. (15820794)Koga K.... Taketani Y.2005IL16
27Peritoneal fluid cytokines and sICAM-1 in minimal endometriosis: search for discriminating factors between infertility and/or endometriosis. (16154044)Skrzypczak J.... Kurpisz M.2005IL6, IL1B, IL8
28Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor. (16274608)Fatemi H.M.... Devroey P.2005CYP19A1
29Expressions of aromatase P450 and estrogen receptor in eutopic and ectopic endometrium in endometriosis and their correlation with endometriosis (15840311)Huang J.... Zhou C.Y.2005ESR1, CYP19A1
30Initial endometriosis showing direct morphologic evidence of metaplasia in the pathogenesis of ovarian endometriosis. (15782073)Zheng W.... Liang S.X.2005CYP19A1
31Expression of allograft inflammatory factor-1 in human eutopic endometrium and endometriosis: possible association with progression of endometriosis. (15507512)Koshiba H.... Honjo H.2005AIF1
32Hepatocyte growth factor may be involved in cellular changes to the peritoneal mesothelium adjacent to pelvic endometriosis. (15019814)Ishimaru T.... Masuzaki H.2004HGF
33Expression of E26 transformation specific (ETS-1) related to angiogenesis in ovarian endometriosis. (15302318)Sakaguchi H.... Tamaya T.2004ETS1
34Recent advances in endometriosis with emphasis on pathogenesis, molecular pathology, and neoplastic transformation. (15381900)Wells M.2004PTEN
35Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correlation with stage and depth of invasion. (12571184)Arici A.... Mahutte N.G.2003IL15
36Expression of serum human leukocyte antigen and growth factor levels in a Greek family with familial endometriosis. (12594002)Matalliotakis I.M.... Vassiliadis S.2003VEGFA
37Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines. (12538037)Matalliotakis I.M.... Vassiliadis S.2003VEGFA, IFNG, CSF1
38The proline form of p53 codon 72 polymorphism is associated with endometriosis. (11779589)Chang C.C.... Lin C.C.2002TP53
39Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis. (12062821)Bischoff F.Z.... Simpson J.L.2002TP53
40Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. (12364474)Bruner-Tran K.L.... Osteen K.G.2002MMP3, MMP7
41Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis. (11327093)D'Hooghe T.M.... Hill J.A.2001TNF, IL6, IL10
42Increase in serum leptin concentrations among women w ith endometriosis during danazol and leuprolide depot treatments. (10920309)Matalliotakis I.M.... Koumantakis E.E.2000LSL
43Measurements of interleukin-6, interleukin-8 and transforming growth factor-beta 1 levels in peritoneal fluid of patients with endometriosis (11776170)Hao M.... Dong M.2000IL6, IL8
44Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. (10731122)Bulun S.E.... Sasano H.1999NR5A1, CYP19A1
45Vesical endometriosis. Report of a case with immunohistochemical study (9182496)Tarragona Foradada J.... de Torres Mateos J.A.1997PGR
46Human endometriosis-derived permanent cell line (FbEM-1): establishment and characterization. (9286736)Bouquet de JoliniA"re J.... Gogusev J.1997PTPRC, GNRH1
47Antibodies to endometrial transferrin and alpha 2-Heremans Schmidt (HS) glycoprotein in patients with endometriosis. (8738720)Pillai S.... Zhang H.1996AHSG
48Multiple polypoid endometriosis--a rare complication following withdrawal of gonadotrophin releasing hormone (GnRH) agonist for severe endometriosis: a case report. (8798320)Othman N.H.... Ismail Z.1996GNRH1
49Effect of endometriosis pill No. 2 on beta-endorphin and dynorphin in endometriosis (8098971)Yu C.Q.... Wang Z.Q.1993PDYN
50Tissue factors influencing growth and maintenance of endometriosis. (1905894)Melega C.... Flamigni C.1991PGR, ESR1

Expression for genes affiliated with Endometriosis

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Endometriosis

Pathways for genes affiliated with Endometriosis

about this section
Sources:
36QIAGEN, 20KEGG, 38Reactome, 3Cell Signaling Technology, 10EMD Millipore, 41Thomson Reuters
See all sources

Pathways related to endometriosis according to GeneDecks:

(show top 50)    (show all 197)
idPathwayScoreTop Affiliating Genes
1p38 Signaling3613.8KITLG, VEGFC, BMP6, LIF, PAK1, KDR
2Cytokine-cytokine receptor interaction2013.8CNTF, KITLG, VEGFA, VEGFC, LIF, KDR
3ERK Signaling3613.3KITLG, BRAF, VEGFC, BMP6, PAK1, LHB
4MIF Mediated Glucocorticoid Regulation3613.1BMP6, LIF, BCL2, BAX, MIF, IL10
5PAK Pathway3612.9KITLG, VEGFC, BMP6, LIF, PAK1, KDR
6MIF Regulation of Innate Immune Cells3612.8BMP6, LIF, BCL2, BAX, FOS, MIF
7Molecular Mechanisms of Cancer3612.7KITLG, BRCA1, VEGFC, BMP6, LIF, KDR
8Immune System3812.6KIR2DL1, KIR2DL3, KIR3DS1, KIR3DL1, VCAM1, S100A12
9IL-6 Pathway3612.3BRAF, BMP6, BAX, IL10, IL11, IL16
10Glucocorticoid Receptor Signaling3612.3NCOA1, NCOR1, NCOR2, BMP6, BCL2, BAX
11Angiogenesis312.3VEGFC, KDR, MST1R, ITGA5, ITGA6, ITGAV
12Glioma Invasiveness3612.2KITLG, VTN, VEGFC, BMP6, LHB, CD44
13Chemokine signaling pathway2012.0PIK3CA, RELA, BRAF, PAK1, CHUK, IL8
14NFAT Signaling and Lymphocyte Interactions3611.7BMP6, BCL2, BAX, IL11, IL13, IL15
15PTEN Pathway3611.6KITLG, BRAF, VEGFC, KDR, LHB, LAMA1
16Cell adhesion ECM remodeling1011.3VTN, SERPINE1, VCAN, LAMA1, LAMB1, LAMC1
17Paxillin Interactions3611.1KITLG, VEGFC, PAK1, KDR, LHB, AXL
18Cell adhesion_ECM remodeling4111.1VTN, SERPINE1, VCAN, LAMA1, LAMB1, LAMC1
19Signal transduction AKT signaling1011.0RHEB
20Tuberculosis2011.0RELA, VDR, BCL2, BAX, JAK1, IL10
21Toll-like receptor signaling pathway2010.9PIK3CA, RELA, CHUK, CD40, FOS, IRF5
22Apoptotic Pathways in Synovial Fibroblasts3610.7KITLG, VEGFC, BMP6, KDR, LHB, FLT1
23p53 Mediated Apoptosis3610.7KITLG, VEGFC, BMP6, KDR, BCL2, LHB
2414-3-3 Induced Intracellular Signaling3610.7KITLG, VEGFC, LHB, AXL, MST1R, FLT1
25Pancreatic Adenocarcinoma3610.7KITLG, BRAF, BRCA2, VEGFC, BMP6, BIRC5
26Pancreatic cancer2010.7BRCA2
27Breast Cancer Regulation by Stathmin13610.6PAK1, LHB, AXL, MST1R, FGF1, FGF2
28Pertussis2010.6RELA, CFL1, ITGA5, ITGB1, FOS, IL10
29Focal adhesion2010.6PIK3CA, VTN, BRAF, VEGFC, PAK1, KDR
30Nuclear Receptor Activation by Vitamin-A3610.6NCOA1, KITLG, VEGFC, BMP6, KDR, LHB
31PPAR Pathway3610.6NCOA1, KITLG, VEGFC, LHB, ITGA3, ITGA5
32Intracellular Calcium Signaling3610.5KITLG, VEGFC, BMP6, KDR, LHB, AXL
33Activation of cAMP-Dependent PKA3610.4KITLG, VEGFC, KDR, LHB, UCN, AXL
34Activation of PKA through GPCR3610.4KITLG, BRAF, VEGFC, BMP6, KDR, LHB
35Estrogen Pathway3610.3NCOA1, NCOR1, NCOR2, KITLG, BRAF, BRCA1
36Activation of PKC through GPCR3610.3KITLG, VEGFC, BMP6, KDR, LHB, FLT1
37GSK3 Signaling3610.3KITLG, VEGFC, BMP6, KDR, LHB, AXL
38GPCR Pathway3610.2KITLG, BRAF, VEGFC, BMP6, PAK1, KDR
39Development IGF-RI signaling1010.2PIK3CA, RELA, BCL2L1, CHUK, MTOR, MAPK3
40MAPK signaling pathway2010.1RELA, BRAF, PAK1, CHUK, FOS, FGF1
41p70S6K Signaling369.9KITLG, VEGFC, BMP6, KDR, LHB, JAK1
42Signal transduction PTEN pathway109.9PIK3CA, PCNA, MTOR, CDKN1A, ITGA5, ITGB1
43Rap1 Pathway369.8KITLG, BRAF, VEGFC, BMP6, LHB, ITGA3
44Pathways in cancer209.7PIK3CA, RELA, BRCA2, VEGFA, VEGFC, BIRC5
45P2Y Receptor Signaling369.6BRAF, VEGFC, KDR, AXL, FOS, FLT1
46Transcription Androgen Receptor nuclear signaling109.5NCOA1, NCOR1, CDKN1A, MMP2, AR, IL6
47Transcription_Androgen Receptor nuclear signaling419.5NCOA1, NCOR1, CDKN1A, MMP2, AR, IL6
48Development_EGFR signaling pathway419.4PIK3CA, PAK1, CHUK, JAK1, MMP2, MMP9
49Glioma208.8PIK3CA, BRAF, MTOR, CDKN1A, CDKN2A, MAPK3
50Prostate cancer208.5PIK3CA, RELA, BRAF, BCL2, CHUK, MTOR

Compounds for genes affiliated with Endometriosis

about this section
Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to endometriosis according to GeneDecks:

(show top 50)    (show all 460)
idCompoundScoreTop Affiliating Genes
1estradiol32 9 18 9 20.8NCOA1, NCOR1, NCOR2, KITLG, PCNA, GC
2oxygen32 18 17.4KITLG, SERPINF1, BRCA1, LIF, BIRC5, CLOCK
3cholesterol32 9 18 9 18.5PIK3CA, NCOA1, KITLG, VTN, GC, SERPINA6
4matrigel32 15.0PIK3CA, VTN, SERPINF1, SERPINB2, SERPINE1, VIM
5mifepristone32 42 9 9 17.1PIBF1, NCOA1, NCOR1, NCOR2, SERPINA6, LIF
6glutamate32 14.0PIK3CA, NCOA1, VTN, PCNA, GC, SERPINF1
7superoxide32 18 14.8PIK3CA, CNTF, KITLG, GC, SERPINB2, VCAM1
8fibrinogen32 13.8VTN, GC, SERPINC1, SERPINB2, SERPINE1, VCAM1
9creatinine32 13.7KITLG, PCNA, GC, SERPINC1, VDR, BMP6
10methionine32 13.6CNTF, SERPINF1, SERPINB2, VIM, LIF, PARK7
11leucine32 13.4PIK3CA, NCOA1, KIR3DL1, VIM, USF2, USF1
12acth32 13.4SERPINA6, VIP, LEP, LEPR, MUC1, UCN
13dopamine32 9 18 9 16.0PIK3CA, CNTF, VIP, BMP6, LIF, CLOCK
14polyacrylamide32 12.8GC, SERPINA6, BRCA1, BRCA2, VCAN, LEPR
15estrone32 9 18 9 15.6SERPINA6, BGLAP, LEP, ARSH, AR, IGFBP1
16glycogen32 18 13.6PIK3CA, VIM, LIF, LEPR, CHGA, CHUK
17ascorbic acid32 18 13.6CNTF, PCNA, SERPINB2, NAT1, VDR, LIF
18danazol32 9 18 9 15.1PCNA, SERPINC1, CDH1, MMP3, ARSH, AR
19dehydroepiandrosterone sulfate32 11.7SERPINA6, LEP, UCN, CGA, ARSH, AR
20homocysteine32 18 12.7SERPINC1, SERPINE1, NAT1, NAT2, VCAM1, MIF
21flutamide32 9 9 13.7CHGA, CGA, AR, GNRH1, ESR1, TNFRSF11B
22curcumin32 11.6VTN, NAT1, VEGFA, VCAM1, BIRC5, BCL2
23choline32 9 18 9 14.5CNTF, VIM, VIP, LIF, LEPR, MTHFR
24glycosaminoglycan32 11.5VTN, SERPINC1, VCAN, PAPPA, AZU1, CD36
25nadph32 18 12.4PIK3CA, CLOCK, PAK1, XRCC1, FPR2, MGST1
26tibolone32 11.4SERPINC1, SERPINE1, BGLAP, PAEP, LEP, MMP1
27phorbol32 11.3SERPINB2, CHGA, CHUK, CDKN1A, CD69, CD40
28manganese superoxide32 11.2SERPINB2, VCAM1, BCL2L1, XRCC1, CD40, GSTM1
29theophylline32 9 18 9 14.2CHGA, XDH, CGA, CD79A, CD40LG, IL10
30triptolide32 11.2VEGFA, BCL2, BAX, CD40, MMP3, IL1B
31nocodazole32 42 9 9 14.2VTN, VIM, BRCA1, BIRC5, CD79A, CDKN1A
32mip 1alpha32 11.0IL10, IL13, IL1B, IL4, IL6, IL8
33ceramide32 11.0PIK3CA, CNKSR1, BCL2L1, CDKN1B, CDK1, MAPK3
34isoproterenol32 9 9 13.0VIM, BRAF, LIF, CHGA, AR, FGF2
35ribavirin32 34 9 9 13.9LEP, CD40LG, MMP1, MMP2, MMP9, IL10
36anti-fungal32 10.9CHGA, CD79A, CDKN2A, CD40LG, IL15, IL5
37p00532 10.8BRCA1, BIRC5, MKI67, ENG, CCL5, IGFBP1
38c2ceramide32 10.8BCL2L1, CHUK, BAX, IL1B, MAPK8, CASP3
395-hydroxytryptamine32 10.7SERPINE1, VIM, VIP, BMP6, PAK1, CHGA
40rituximab32 34 9 9 13.7BIRC5, BCL2, BCL2L1, MTOR, CD79A, CD40LG
41zoledronic acid32 10.7BGLAP, CD36, MMP9, IL2, ALPP, GNRH1
42guanine32 9 18 9 13.6VIP, BRCA1, VDR, USF1, BIRC5, CHGA
43s-nitroso-n-acetylpenicillamine32 10.2XDH, FN1, IL1B, IL8, IFNG, IDO1
44bleomycin32 9 9 12.1BRCA1, BRCA2, XRCC1, CD44, GSTM1, GSTP1
45agar32 10.0PIK3CA, KITLG, VIM, BRAF, BRCA1, BIRC5
46batimastat32 42 9 9 13.0CD36, MMP1, MMP11, MMP12, MMP13, MMP14
47irinotecan32 34 9 9 12.7BRAF, VEGFA, BCL2L1, BAX, MTHFR, XRCC1
48alanine32 INFNCOA1, CNTF, KITLG, VTN, PCNA, SERPINC1
49thymidylate32 INFPCNA, VIM, BRCA1, VEGFA, VDR, BIRC5
50atp32 INFPIK3CA, KIR3DL1, VTN, BRAF, BRCA1, LIF

GO Terms for genes affiliated with Endometriosis

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to endometriosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557618.5CCL11, CALCA, HP, HPSE, ESR2, GH1
2cytoplasmGO:00573715.8NOS2, PLA2G6, NR3C1, NR1H2, PPIG, CTNNB1
3extracellular spaceGO:00561514.9EPO, AFM, AFP, GAS6, GDF9, HGF
4plasma membraneGO:00588614.6GNRHR, TNFRSF1A, TNFRSF1B, TNFSF13B, TEK, PTEN
5integral to plasma membraneGO:00588714.3KIR2DL1, EPHA3, EPOR, KIR2DL3, ITGB3, MME
6cytosolGO:00582912.4SRC, CYP19A1, SULT1E1, PTK2, PTEN, CTNNB1
7cell surfaceGO:00998612.3ENG, CCR5, ALPP, HSPD1, TNF, TNFRSF1A
8extracellular matrixGO:03101211.6ANXA2, IHH, IGFBP7, TNC, CTSD, COL18A1
9external side of plasma membraneGO:00989711.5FASLG, FAS, ENG, CCR5, CCR1, IFNG
10platelet alpha granule lumenGO:03109310.1ACTN1, TIMP1, THBS1, TGFB1, HGF, GAS6

Biological processes related to endometriosis according to GeneDecks:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716514.1CNTF, KITLG, VEGFC, VDR, CLOCK, LHB
2immune responseGO:00695514.1KIR2DL1, KIR2DL3, KIR3DS1, KIR3DL1, VTN, SEMA3C
3inflammatory responseGO:00695413.7RELA, BMP6, PARK7, CHI3L1, CHUK, UCN
4cell-cell signalingGO:00726713.5PCSK5, LHB, CGA, AR, INHA, INHBA
5cell adhesionGO:00715512.6KITLG, VTN, VCAM1, VCAN, BGLAP, MUC16
6female pregnancyGO:00756512.6GC, CLDN4, PAPPA, BCL2, LEP, UCN
7chemotaxisGO:00693512.5L1CAM, FPR2, FGF2, IL4, MAPK1, CCR2
8angiogenesisGO:00152512.4PIK3CA, SERPINE1, VEGFA, VEGFC, KDR, ITGA5
9positive regulation of angiogenesisGO:04576612.2SERPINE1, VEGFA, KDR, CHI3L1, MMP9, FLT1
10negative regulation of cell proliferationGO:00828512.2SFRP4, VDR, RARRES1, LIF, CDKN1A, CDKN1B
11cytokine-mediated signaling pathwayGO:01922112.2RELA, VCAM1, UBC, JAK1, CD44, IRF5
12positive regulation of cell proliferationGO:00828412.1CNTF, VIP, VEGFA, VEGFC, LIF, BIRC5
13leukocyte migrationGO:05090012.0PIK3CA, BSG, L1CAM, ITGA3, ITGA5, ITGA6
14male gonad developmentGO:00858412.0KITLG, BCL2, BCL2L1, LHB, FSHR, FSTL3
15positive regulation of ERK1 and ERK2 cascadeGO:07037411.9BRAF, KDR, CHI3L1, CD44, MIF, FGF2
16positive regulation of peptidyl-serine phosphorylationGO:03313811.7PIK3CA, BRAF, VEGFA, LIF, PAK1, BCL2
17positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.7KITLG, VTN, VEGFA, LIF, MTOR, CD36
18response to estradiol stimulusGO:03235511.7NCOA1, SFRP4, GC, BRCA2, VDR, UCN
19response to glucocorticoid stimulusGO:05138411.7SFRP4, SERPINF1, SERPINE1, BGLAP, UCN, IL10
20response to hypoxiaGO:00166611.7VEGFA, VCAM1, USF1, CLDN3, PAK1, BCL2
21positive regulation of cell migrationGO:03033511.6VEGFA, KDR, LAMB1, CGA, ITGAV, ITGB1
22innate immune responseGO:04508711.6RELA, BCL2, BCL2L1, CHUK, UBC, S100A12
23blood coagulationGO:00759611.6PIK3CA, SERPINC1, SERPINB2, SERPINE1, BSG, VEGFA
24positive regulation of MAPK cascadeGO:04341011.5CNTF, LIF, KDR, LEP, CD36, CDH2
25negative regulation of apoptotic processGO:04306611.3RELA, SERPINE1, BRAF, VEGFA, KDR, BCL2
26anti-apoptosisGO:00691611.3PIK3CA, RELA, SERPINB2, BRAF, BIRC5, BCL2
27positive regulation of NF-kappaB transcription factor activityGO:05109211.3RELA, CHUK, UBC, CD40, AR, GREM1
28positive regulation of gene expressionGO:01062811.3SFRP4, BRAF, VEGFA, VDR, CDK1, CD44
29apoptotic processGO:00691511.2VIM, BRCA1, BIRC5, PAK1, BCL2, BCL2L1
30elevation of cytosolic calcium ion concentrationGO:00720411.2IL1B, IL2, CCR2, CCR8, CCR5, CCR1
31embryo implantationGO:00756611.2KLF9, PCSK5, BSG, LIF, LAMB1, MMP9
32response to ethanolGO:04547111.1BGLAP, BCL2, CDK1, MMP9, IL13, IL4
33cell surface receptor signaling pathwayGO:00716611.1BSG, LEPR, LAMA1, CD36, MIF, INHA
34response to organic cyclic compoundGO:01407011.1CDKN1A, CD83, CDK1, MET, IL1A, IL1RN
35positive regulation of protein phosphorylationGO:00193411.1VEGFA, MTOR, CD40, ITGB3, FGF1, IL1B
36response to lipopolysaccharideGO:03249611.0MMP9, MGST1, IL13, IL1A, FASLG, FAS
37positive regulation of cell divisionGO:05178110.9VEGFA, VEGFC, FGF1, FGF2, FGF9, FGFR2
38positive regulation of protein kinase B signaling cascadeGO:05189710.8CHI3L1, MTOR, AXL, MST1R, ANGPT1, CCL3
39platelet activationGO:03016810.7PIK3CA, SERPINE1, VEGFA, VEGFC, LEFTY2, AXL
40cellular response to interleukin-1GO:07134710.6RELA, CHI3L1, MMP9, IL17A, IL8, CCL2
41positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.6CNTF, KDR, FLT1, ANGPT1, CCL5, IGF1
42platelet degranulationGO:00257610.5SERPINE1, VEGFA, VEGFC, LEFTY2, CFL1, CD36
43activation of MAPK activityGO:00018710.4UBC, CDK1, FGF2, MET, IL1B, MAPK3
44positive regulation of transcription, DNA-dependentGO:04589310.2NCOA1, RELA, BRCA1, BRCA2, CDKN2A, CDH1
45positive regulation of MAP kinase activityGO:0434068.9KITLG, VEGFA, MST1R, CD40, FLT1, GH1
46agingGO:007568INFSERPINF1, VDR, VCAM1, IL15, IL1B, FAS
47cell proliferationGO:008283INFKITLG, PCNA, SERPINF1, BCL2L1, UCN2, MKI67
48positive regulation of transcription from RNA polymerase II promoterGO:045944INFNCOA1, RELA, SERPINE1, BRCA1, VEGFA, VDR
49positive regulation of apoptotic processGO:043065INFNCOA1, SFRP4, BAX, ITGA6, ITGB1, MMP9
50response to drugGO:042493INFSEMA3C, VEGFC, BGLAP, PARK7, BCL2, XRCC1

Molecular functions related to endometriosis according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510212.7SERPINE1, RARRES2, LIF, LHB, UCN2, LAMA1
2cytokine activityGO:00512512.1IFNA2, GDF9, ADIPOQ, IFNG, TNF, TNFRSF11B
3chemokine activityGO:00800911.7CXCL1, CXCL10, CXCL11, CXCL5, CXCL6, CCL5
4heparin bindingGO:00820111.3CCL2, CCL5, PTN, PTPRC, CYR61, LTF
5growth factor activityGO:00808311.0BMP6, LIF, LEFTY2, LEP, INHA, INHBA
6hormone activityGO:00517910.3GNRH1, CALCA, GH1, CRH, EDN1, PRL
7enzyme bindingGO:019899INFCTNNB1, CYP2E1, CYP2C19, PTGS2, PTEN, PPARG
8protein bindingGO:005515INFELN, DNMT3A, DNMT1, TACR1, TAGLN2, DES
9protein homodimerization activityGO:042803INFIL17F, PTGS2, SRF, NTRK1, NTRK2, NR2F2

Sources for Endometriosis

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z