MCID: END044
MIFTS: 61

Endometriosis malady

Reproductive category

Summaries for Endometriosis

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Endometriosis is a problem affecting a woman's uterus - the place where a baby grows when she's pregnant. endometriosis is when the kind of tissue that normally lines the uterus grows somewhere else. it can grow on the ovaries, behind the uterus or on the bowels or bladder. rarely, it grows in other parts of the body. this "misplaced" tissue can cause pain, infertility, and very heavy periods. the pain is usually in the abdomen, lower back or pelvic areas. some women have no symptoms at all. having trouble getting pregnant may be the first sign. the cause of endometriosis is not known. pain medicines and hormones often help. severe cases may need surgery. there are also treatments to improve fertility in women with endometriosis.

MalaCards: Endometriosis, also known as endometriosis, site unspecified, is related to infertility and adenocarcinoma. An important gene associated with Endometriosis is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Estrogen metabolism and Glucuronidation. The drugs danazol and ethynodiol diacetate and the compounds estradiol and progesterone have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and hematopoietic system.

Wikipedia:64 Endometriosis is a gynecological condition in which cells from the lining of the uterus (endometrium)... more...

Aliases & Classifications for Endometriosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

endometriosis 8 10 45 34
endometriosis, site unspecified 61


External Ids:

Disease Ontology8 DOID:289
MeSH35 D004715
ICD9CM27 617, 617.9
NCIt40 C3014
ICD1025 N80, N80.9

Related Diseases for Endometriosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Endometriosis family:

endometriosis 1 rare endometriosis

Diseases related to Endometriosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.1GNRH1, CYP1A1, CYP19A1, IL11, FST, ESR2
2adenocarcinoma31.0STS, ARSH, HGF, HNF1B, VEGFA, MUC16
3endometrial stromal sarcoma30.8CYP19A1, PGR, ESR2
4progesterone resistance30.4PGR
5myoma30.4PGR, CYP19A1, GNRH1
6adenofibroma30.3MUC16
7adenoma30.2GNRH1, CYP1A1, CYP1B1, FST, ESR2
8uterine fibroid30.2GNRH1, STS, MUC16, CYP19A1, PGR, ESR2
9papillary carcinoma30.1HGF, MUC16, PGR
10atherosclerosis29.9CYP1A1, FST, ESR2
11colorectal cancer29.7ESR2, CYP1B1, CYP1A1, MUC16, VEGFA, HGF
12pregnancy loss29.7GNRH1, CYP1A1, CYP1B1
13uterine disease29.7HNF1B, CYP19A1
14estrogen excess29.7CYP19A1, PGR
15ovarian serous cystadenocarcinoma29.7MUC16
16ovarian endometriosis11.0
17adenomyosis10.8
18endometriosis 110.6
19rare endometriosis10.6
20clear cell adenocarcinoma10.5
21catamenial pneumothorax10.4
22adenosarcoma10.4
23cervix endometriosis10.4
24fallopian tube endometriosis10.3
25chronic pain10.3
26ureteral obstruction10.2
27ectopic pregnancy10.2
28cystadenoma10.2
29endosalpingiosis10.2
30endometriosis of ovary10.2
31hydronephrosis10.2
32ovarian clear cell adenocarcinoma10.2
33n syndrome10.2
34ovarian epithelial cancer10.2
35pseudomyxoma peritonei10.1
36intussusception10.1
37appendicitis10.1
38clear cell adenofibroma10.1
39teratoma10.1
40endometriosis of intestine10.1
41endometriosis of pelvic peritoneum10.1
42endometriosis of rectovaginal septum and vagina10.1
43endometriosis in scar of skin10.1
44ovarian squamous cell carcinoma10.1
45vaginal adenosarcoma10.1
46irritable bowel syndrome10.1
47anovulation10.1
48squamous cell carcinoma10.1
49gliomatosis peritonei10.1
50peritoneal carcinoma10.1

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to endometriosis

Clinical Features for Endometriosis

Drugs & Therapeutics for Endometriosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endometriosis

Drug clinical trials:

Search ClinicalTrials for Endometriosis

Search NIH Clinical Center for Endometriosis

Search CenterWatch for Endometriosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Endometriosis

Anatomical Context for Endometriosis

Animal Models for Endometriosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Endometriosis

Sources:
51PubMed
See all sources

Articles related to Endometriosis:

(show top 50)    (show all 2147)
idTitleAuthorsYear
1
Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis. (23203215)
2013
2
Deep endometriosis and bladder and detrusor functions in women without urinary symptoms: a pilot study through an unexplored world. (23891020)
2013
3
Low-grade MA1llerian adenosarcoma with prominent decidualization, involving bilateral ovaries against a background of endometriosis: a diagnostic and treatment challenge. (23793320)
2013
4
A rare case of Endometriosis in vaginal hysterectomy scar. (23816336)
2013
5
Soluble c-Met expression in the peritoneal fluid and serum of patients with different stages of endometriosis. (24213016)
2013
6
Rectal endometriosis -rare case of intestinal obstruction. Case report. (23640931)
2013
7
Scar endometriosis in a patient with bladder exstrophy. (23701150)
2013
8
Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis. (23828228)
2013
9
The association of PTPN22 polymorphism with endometriosis: effect of genetic and clinical factors. (23453606)
2013
10
Ileocolic intussusception due to a cecal endometriosis: case report and review of literature. (22676322)
2012
11
Association of E-cadherin single nucleotide polymorphisms with the increased risk of endometriosis in Indian women. (22184339)
2012
12
Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis. (22626277)
2012
13
Association of the IL-6 gene 634C/G polymorphism with susceptibility to endometriosis]. (21983734)
2011
14
Association of single nucleotide polymorphism in CYP17 and ERI+ genes with endometriosis risk in southern Chinese women]. (21644229)
2011
15
Influence of nerve growth factor in endometriosis-associated symptoms. (21673280)
2011
16
MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility. (21349170)
2011
17
Endometrial stromal sarcoma from endometriosis. (20728821)
2010
18
Expression of the human endogenous retroviruse-W envelope gene syncytin in endometriosis lesions. (19903052)
2009
19
Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study. (19545488)
2009
20
Estrogen receptor-alpha gene (T/C) Pvu II polymorphism in endometriosis and uterine fibroids. (19729795)
2009
21
Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis. (19903051)
2009
22
Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis. (18384777)
2009
23
Expression of Fox head protein 1 in human eutopic endometrium and endometriosis. (18332236)
2008
24
Variants in EMX2 and PTEN do not contribute to risk of endometriosis. (17563403)
2007
25
Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample. (17595314)
2007
26
Construction of the recombinant adenovirus vector of interleukin-1 receptor II and its expression in eutopic stromal cells of endometriosis]. (18062876)
2007
27
Expression of epidermal growth factor, fibroblast growth factor-2, and platelet-derived growth factor-A in the eutopic endometrium of women with endometriosis. (17578349)
2007
28
Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. (17952761)
2007
29
Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. (16418212)
2006
30
Expression of the fibrinolytic components in endometriosis. (16855359)
2006
31
Regulation of hepatocyte growth factor by basal and stimulated macrophages in women with endometriosis. (15602080)
2005
32
Anastrazole and oral contraceptives: a novel treatment for endometriosis. (16084868)
2005
33
Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population. (15784508)
2005
34
Study on the changes of T-lymphocyte subsets in the patients with endometriosis]. (15774086)
2005
35
Androgen receptor gene cytosine, adenine, and guanine trinucleotide repeats in patients with endometriosis. (15120698)
2004
36
Expression of heparanase gene in eutopic and ectopic endometrium of women with endometriosis]. (14989983)
2004
37
Endometriosis: interaction of immune and endocrine systems. (12917783)
2003
38
Associations between patients with endometriosis and HLA class II; the analysis of HLA-DQB1 and HLA-DPB1 genotypes. (12721173)
2003
39
Selective progesterone receptor modulators (SPRMs): a novel therapeutic concept in endometriosis. (11949964)
2002
40
Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis. (11327093)
2001
41
Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis. (11383925)
2001
42
Localization in tissues and secretion of eotaxin by cells from normal endometrium and endometriosis. (10902814)
2000
43
Correspondence re: Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol 1998;11:784-8. (10071345)
1999
44
Vesical endometriosis. Report of a case with immunohistochemical study]. (9182496)
1997
45
Transferrin receptor (CD71) expression in peritoneal macrophages from fertile and infertile women with and without endometriosis. (9412724)
1997
46
IL-1 beta, TNF-alpha, and IL-2 in peritoneal fluid and macrophage-conditioned media of women with endometriosis. (8607944)
1995
47
Cytokines in the peritoneal fluid of patients with endometriosis. (7904954)
1993
48
Effect of ovarian endometriosis on ovulation in rabbits. (2912100)
1989
49
Malignant transformation of ovarian endometriosis. Nature, treatment and report of two cases. (5451141)
1970
50
OBSERVATIONS ON METAPLASTIC CHANGES IN THE GERMINAL EPITHELIUM OF THE OVARY AND ON THE AETIOLOGY OF OVARIAN ENDOMETRIOSIS. (14299344)
1965

Genetic Variations for Endometriosis

Expression for genes affiliated with Endometriosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endometriosis

Search GEO for disease gene expression data for Endometriosis.

Pathways for genes affiliated with Endometriosis

Sources:
38NCBI BioSystems Database, 50PharmGKB, 30KEGG, 12EMD Millipore, 54Reactome
See all sources

Compounds for genes affiliated with Endometriosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Endometriosis according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1estradiol45 11 2414.9ESR2, CYP1A1, MUC16, STS, ARSH, GNRH1
2progesterone45 60 29 11 2416.8CYP1B1, PGR, IL11, FST, SERPINA6, ESR2
3testosterone45 60 11 2415.8HSD17B1, HGF, GNRH1, ARSH, STS, MUC16
4steroid4512.6IL11, CYP1B1, CYP19A1, MUC16, STS, ARSH
5retinoic acid45 2413.5ESR2, HNF1B, HGF, GNRH1, IL11, STS
6estrone45 29 11 2415.4PGR, CYP1B1, CYP19A1, CYP1A1, ARSH, GNRH1
7tamoxifen45 50 29 1115.3VEGFA, CYP1B1, CYP19A1, CYP1A1, SERPINA6, STS
8dihydrotestosterone45 29 11 2415.2HSD17B1, GNRH1, ARSH, STS, CYP19A1, SERPINA6
9doxorubicin45 50 1114.0VEGFA, MUC16, CYP19A1, CYP1B1, PGR, IL11
10genistein45 29 60 2 11 2417.0VEGFA, PGR, CYP1B1, CYP19A1, CYP1A1, HGF
11adenylate4511.9SERPINA6, GNRH1, HGF, ESR2, RXFP1, FST
12steroidal4511.9GNRH1, ESR2, SERPINA6, PGR, CYP19A1, ARSH
1317beta-hydroxysteroid4511.9HSD17B1, STS, CYP19A1, CYP1B1, PGR, ESR2
14dexamethasone45 50 29 1114.9VEGFA, MUC16, CYP1A1, FST, GNRH1, HGF
15progestins4511.9ESR2, PGR, GNRH1, ARSH, STS, CYP19A1
164-hydroxytamoxifen4511.9CYP1B1, CYP19A1, CYP1A1, STS, ESR2, ARSH
17androstenedione45 2412.9ESR2, GNRH1, SERPINA6, CYP1A1, CYP19A1, CYP1B1
18progestin4511.9GNRH1, ARSH, STS, VEGFA, CYP19A1, PGR
19cyclophosphamide45 50 1113.9IL11, HGF, PGR, CYP1B1, CYP19A1, CYP1A1
20paclitaxel45 50 1113.9CYP19A1, CYP1B1, VEGFA, PGR, IL11, HGF
21mifepristone45 60 29 1114.7CYP19A1, VEGFA, PGR, SERPINA6, ESR2, GNRH1
22toremifene45 1112.6CYP19A1, ESR2, GNRH1, CYP1A1, PGR
23tibolone4511.6STS, ARSH, PGR, GNRH1, CYP19A1
24danazol45 11 2413.6PGR, CYP19A1, STS, ARSH, GNRH1
25letrozole45 50 60 1114.6PGR, ESR2, CYP1B1, CYP19A1, STS
26dmso4511.6GNRH1, ESR2, PGR, HGF, CYP1B1, CYP1A1
27flutamide45 60 1113.6GNRH1, CYP1A1, CYP19A1, CYP1B1, PGR
28estrone sulfate45 2412.6ARSH, STS, PGR, CYP1B1, CYP19A1
295fluorouracil4511.5PGR, HGF, IL11, GNRH1, CYP1B1
30diethylstilbestrol45 29 1113.5PGR, ESR2, FST, GNRH1, CYP19A1
31dhea4511.5CYP19A1, ARSH, STS, SERPINA6, ESR2
32gnrh4511.4ESR2, FST, PGR, CYP19A1, ARSH, GNRH1
33gefitinib45 50 1113.4HGF, VEGFA, CYP1A1, CYP19A1, ESR2
34nandrolone45 2412.4ESR2, CYP19A1, PGR, SERPINA6
35estradiol benzoate4511.4GNRH1, ESR2, PGR, CYP19A1
36dehydroepiandrosterone sulfate4511.4STS, SERPINA6, CYP19A1, GNRH1
37leuprolide acetate4511.4GNRH1, CYP19A1, PGR, ESR2
38exemestane50 45 60 1114.3ESR2, PGR, CYP19A1, CYP1B1
39ribonucleic acid4511.3ESR2, SERPINA6, FST, IL11, PGR, GNRH1
40bisphenol a4511.3PGR, ESR2, CYP19A1, ARSH
41clomiphene citrate4511.3ESR2, GNRH1, PGR, CYP19A1
42fulvestrant45 50 29 1114.3ESR2, CYP1A1, PGR, CYP19A1
43cyproteroneacetate4511.2PGR, GNRH1, SERPINA6, CYP19A1
44levonorgestrel45 60 29 1114.1SERPINA6, CYP19A1, PGR, ESR2
45norelgestromin45 1112.1STS, PGR, ARSH
46estrogen4511.1ARSH
4717-hydroxyprogesterone45 2412.0SERPINA6, CYP19A1, MUC16, GNRH1
48cycloheximide4511.0HGF
49dydrogesterone29 45 1112.8STS, PGR, ARSH
50promegestone45 2911.6PGR, STS, ARSH

GO Terms for genes affiliated with Endometriosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3SERPINA6, IL11, MUC16, VEGFA, GNRH1, HGF

Biological processes related to Endometriosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:00820211.1CYP1B1, CYP19A1, HSD17B1
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0IL11, VEGFA, HGF
3cell-cell signalingGO:00726710.9GNRH1, PGR, IL11, ESR2
4omega-hydroxylase P450 pathwayGO:09726710.8CYP1A1, CYP1B1
5estrogen biosynthetic processGO:00670310.8HSD17B1, CYP19A1
6sterol metabolic processGO:01612510.8CYP1B1, CYP19A1
7epoxygenase P450 pathwayGO:01937310.5CYP1B1, CYP1A1

Molecular functions related to Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aromatase activityGO:07033010.9CYP1A1, CYP19A1, CYP1B1
2steroid bindingGO:00549610.8ESR2, PGR, SERPINA6
3oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.8CYP19A1, CYP1B1
4oxygen bindingGO:01982510.6CYP19A1, CYP1A1, CYP1B1

Products for genes affiliated with Endometriosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endometriosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet