MCID: END044
MIFTS: 69

Endometriosis malady

Reproductive diseases category

Summaries for Endometriosis

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Endometriosis is a problem affecting a woman's uterus - the place where a baby grows when she's pregnant. endometriosis is when the kind of tissue that normally lines the uterus grows somewhere else. it can grow on the ovaries, behind the uterus or on the bowels or bladder. rarely, it grows in other parts of the body. this "misplaced" tissue can cause pain, infertility, and very heavy periods. the pain is usually in the abdomen, lower back or pelvic areas. some women have no symptoms at all. having trouble getting pregnant may be the first sign. the cause of endometriosis is not known. pain medicines and hormones often help. severe cases may need surgery. there are also treatments to improve fertility in women with endometriosis.

MalaCards: Endometriosis, also known as endometriosis, site unspecified, is related to peritonitis and infertility. An important gene associated with Endometriosis is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Estrogen metabolism and Glucuronidation. The drugs danazol and ethynodiol diacetate and the compounds estradiol and progesterone have been mentioned in the context of this disorder. Affiliated tissues include endothelial, uterus and ovary, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Wikipedia:63 Endometriosis is a gynecological condition in which cells from the lining of the uterus (endometrium)... more...

Aliases & Classifications for Endometriosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

endometriosis 8 10 44 33
endometriosis, site unspecified 60


External Ids:

Disease Ontology8 DOID:289
MeSH34 D004715
ICD9CM27 617, 617.9
NCIt39 C3014
ICD1025 N80, N80.9

Related Diseases for Endometriosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Endometriosis family:

Endometriosis 1 Rare Endometriosis

Diseases related to Endometriosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.4MUC16
2infertility31.2CYP19A1, ESR2, GNRH1, CYP1A1, FST, IL11
3adenocarcinoma30.9CYP1A1, HNF1B, HGF, ARSH, CYP1B1, STS
4ovarian cancer30.7PGR, ESR2, FST, MUC16, VEGFA, STS
5endometrial stromal sarcoma30.7PGR, CYP19A1, ESR2
6leiomyoma30.5GNRH1, PGR, CYP19A1, ESR2, STS
7endometrial carcinoma30.3PGR, ESR2, MUC16
8ovarian cyst30.3CYP19A1, MUC16, ESR2, GNRH1
9myoma30.3CYP19A1, GNRH1, PGR
10adenofibroma30.2MUC16
11breast cancer30.2STS, ESR2, CYP19A1, PGR, CYP1A1
12ovarian disease30.2MUC16, CYP19A1, GNRH1
13uterine fibroid30.1STS, PGR, CYP19A1, ESR2, MUC16, GNRH1
14adenoma30.1CYP1B1, FST, GNRH1, ESR2, CYP1A1
15colon adenocarcinoma30.1ESR2
16papillary carcinoma30.0PGR, HGF, MUC16
17hepatitis30.0HGF
18prostate cancer29.9ESR2, STS, VEGFA, HNF1B, CYP1A1, CYP19A1
19leukemia29.9FST, CYP1A1, CYP1B1, ESR2, IL11
20atherosclerosis29.9ESR2, FST, CYP1A1
21cervical cancer29.9CYP1A1, MUC16
22colorectal cancer29.7MUC16, CYP1A1, ESR2, CYP1B1, HGF, VEGFA
23lung cancer29.7CYP1A1, CYP1B1, MUC16, VEGFA, HGF, ESR2
24choriocarcinoma29.7STS, GNRH1, CYP19A1, FST, ESR2
25melanoma29.7HGF, FST, CYP1B1, CYP1A1, VEGFA
26leiomyosarcoma29.7PGR, MUC16
27malignant mesothelioma29.7HGF, MUC16
28estrogen excess29.7CYP19A1, PGR
29uterine disease29.7HNF1B, CYP19A1
30ovarian serous cystadenocarcinoma29.7MUC16
31cystadenocarcinoma29.7MUC16
32ovarian endometriosis11.0
33endometriosis of ovary10.6
34sarcoma10.5
35clear cell adenocarcinoma10.5
36pneumothorax10.5
37rare endometriosis10.5
38adenosarcoma10.4
39endometriosis of uterus10.4
40vaginitis10.4
41endometriosis of intestine10.4
42cervix endometriosis10.3
43fallopian tube endometriosis10.3
44cervicitis10.3
45intestinal obstruction10.3
46leiomyomatosis10.3
47pelvic inflammatory disease10.2
48salpingitis10.2
49ureteral obstruction10.2
50cystadenoma10.1

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to endometriosis

Clinical Features for Endometriosis

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Drugs & Therapeutics for Endometriosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endometriosis

Drug clinical trials:

Search ClinicalTrials for Endometriosis

Search NIH Clinical Center for Endometriosis

Search CenterWatch for Endometriosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Endometriosis

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Anatomical Context for Endometriosis

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32MalaCards
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MalaCards organs/tissues related to Endometriosis:

32
Endothelial, Uterus, Ovary, Monocytes, Colon, Testes, T cells, Appendix, Liver, Cervix, Breast, Lymph node, Pituitary, Kidney, Smooth muscle, Bone, Lung, Prostate, Small intestine, Thyroid, Testis, Skeletal muscle, Eye, Cortex

Animal Models for Endometriosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endometriosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537011.7HNF1B, ESR2, SERPINA6, CYP19A1, CYP1A1, VEGFA
2MP:000539711.6RXFP1, HGF, VEGFA, CYP1A1, CYP19A1, PGR
3MP:000539011.4GNRH1, VEGFA, CYP19A1, PGR, FST, RXFP1
4MP:000537611.3HNF1B, CYP1B1, PGR, FST, SERPINA6, GNRH1
5MP:000537911.1HNF1B, RXFP1, FST, ESR2
6MP:001077110.7FST, VEGFA, GNRH1, RXFP1

Publications for Endometriosis

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Sources:
50PubMed
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Articles related to Endometriosis:

(show top 50)    (show all 2146)
idTitleAuthorsYear
1
A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. (23737821)
2013
2
Polymorphic variants of DNMT3A and the risk of endometriosis. (23018098)
2013
3
Uterine sliding sign: a simple sonographic predictor for presence of deep infiltrating endometriosis of the rectum. (23400893)
2013
4
Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. (23184927)
2013
5
Long-term follow-up after ureteral reimplantation in patients with severe deep infiltrating endometriosis. (24017962)
2013
6
A novel pilot study of endometrial stromal cells and immune cell populations in sentinel uterine-draining lymph nodes during the menstrual cycle and in endometriosis. (23719712)
2013
7
Dyspareunia and quality of sex life after surgical excision of endometriosis: a systematic review. (24287289)
2013
8
Use of the levonorgestrel intrauterine system in adolescents with endometriosis. (23518190)
2013
9
Western herbal medicine, epigenetics, and endometriosis. (23738681)
2013
10
Primary ovarian and pararectal hydatid cysts mimicking pelvic endometriosis. (23456529)
2012
11
Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women. (22653586)
2012
12
Expression of transient receptor potentials of vanilloid subtype 1 and pain in endometriosis]. (22883519)
2012
13
Chitotriosidase levels in patients with severe endometriosis. (22132778)
2012
14
Association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors: an updating meta-analysis. (22613790)
2012
15
Interleukin-12 but not interleukin-18 is associated with severe endometriosis. (18295214)
2009
16
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. (18815356)
2009
17
Endometriosis in two sisters with Glanzmann's thrombasthenia. (19647234)
2009
18
Pharmacotherapy for pelvic endometriosis in women]. (19388539)
2009
19
Haplotype analysis of the matrix metalloproteinase-9 gene associated with advanced-stage endometriosis. (18554596)
2009
20
Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis. (18485158)
2008
21
Effect of recombinant human TNF-binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons. (18061171)
2008
22
Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis. (18541621)
2008
23
Multifocal PEComa (PEComatosis) of the female genital tract associated with endometriosis, diffuse adenomyosis, and endometrial atypical hyperplasia. (18499690)
2008
24
Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. (19238747)
2008
25
Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1. (17631002)
2007
26
Endometriosis with intestinal perforation in term pregnancy. (16545813)
2006
27
Macrophage migration inhibitory factor expression in the intrauterine endometrium of women with endometriosis varies with disease stage, infertility status, and pelvic pain. (16616746)
2006
28
Angiopoietin-1, angiopoietin-2 and Tie-2 expression in eutopic endometrium in advanced endometriosis. (16723371)
2006
29
Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis. (15755869)
2005
30
Leptin is not involved in the pathophysiology of endometriosis-related infertility. (15808381)
2005
31
Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations. (15823822)
2005
32
Endometrioid adenocarcinoma arising from endometriosis of the mesenterium of the sigmoid colon. (15741306)
2005
33
Ureteral endometriosis and ovarian mucinous cystadenoma presenting with acute pyonephrosis. (15868895)
2005
34
Estrogen receptor alpha dinucleotide repeat and cytochrome P450c17alpha gene polymorphisms are associated with susceptibility to endometriosis. (15749482)
2005
35
Interleukin-2 receptor beta (IL-2R beta)-627*C homozygote but not IL-12R beta 1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis. (16084898)
2005
36
Changes in cytokine levels of patients with ovarian endometriosis after treatment with gonadotropin-releasing hormone analogue, ultrasound-guided drainage, and intracystic recombinant interleukin-2. (15820793)
2005
37
Catamenial pneumothorax and other thoracic manifestations of endometriosis. (15099891)
2004
38
Observation of epithelial atypia associated with intranuclear inclusions in ovarian endometriosis. (15192971)
2004
39
Changes of vascular endothelial growth factor and erythropoietin in the peritoneal environment with endometriosis and its significance]. (16137061)
2004
40
Association of an A allele for interleukin-10 -627 gene promoter polymorphism with higher susceptibility to endometriosis. (14562641)
2003
41
Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis]. (14505258)
2003
42
Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis. (11949943)
2002
43
Composite tumor consisting of dermatofibrosarcoma protuberans and giant cell fibroblastoma associated with intratumoral endometriosis. Report of a case. (11358013)
2001
44
Bladder endometriosis must be considered as bladder adenomyosis. (11119746)
2000
45
A novel in vitro experimental model for ovarian endometriosis: the three-dimensional culture of human ovarian surface epithelial cells in collagen gels. (9935115)
1999
46
Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. (8988701)
1997
47
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. (8755660)
1996
48
Localization of progesterone-associated endometrial protein mRNA by in-situ hybridization in human pregnancy decidua, endometriosis and borderline endometrioid adenoma. (8452641)
1993
49
Tissue factors influencing growth and maintenance of endometriosis. (1905894)
1991
50
Carcinomatous change in ovarian endometriosis. (5042438)
1972

Genetic Variations for Endometriosis

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Expression for genes affiliated with Endometriosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endometriosis

Search GEO for disease gene expression data for Endometriosis.

Pathways for genes affiliated with Endometriosis

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Endometriosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Endometriosis according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2414.9ESR2, CYP1A1, MUC16, STS, ARSH, GNRH1
2progesterone44 59 28 11 2416.8CYP1B1, PGR, IL11, FST, SERPINA6, ESR2
3testosterone44 59 11 2415.8HSD17B1, HGF, GNRH1, ARSH, STS, MUC16
4steroid4412.6IL11, CYP1B1, CYP19A1, MUC16, STS, ARSH
5retinoic acid44 2413.5ESR2, HNF1B, HGF, GNRH1, IL11, STS
6estrone44 28 11 2415.4PGR, CYP1B1, CYP19A1, CYP1A1, ARSH, GNRH1
7tamoxifen44 49 28 1115.3VEGFA, CYP1B1, CYP19A1, CYP1A1, SERPINA6, STS
8dihydrotestosterone44 28 11 2415.2HSD17B1, GNRH1, ARSH, STS, CYP19A1, SERPINA6
9doxorubicin44 49 1114.0VEGFA, MUC16, CYP19A1, CYP1B1, PGR, IL11
10genistein44 28 59 2 11 2417.0VEGFA, PGR, CYP1B1, CYP19A1, CYP1A1, HGF
11adenylate4411.9SERPINA6, GNRH1, HGF, ESR2, RXFP1, FST
12steroidal4411.9GNRH1, ESR2, SERPINA6, PGR, CYP19A1, ARSH
1317beta-hydroxysteroid4411.9HSD17B1, STS, CYP19A1, CYP1B1, PGR, ESR2
14dexamethasone44 49 28 1114.9VEGFA, MUC16, CYP1A1, FST, GNRH1, HGF
15progestins4411.9ESR2, PGR, GNRH1, ARSH, STS, CYP19A1
164-hydroxytamoxifen4411.9CYP1B1, CYP19A1, CYP1A1, STS, ESR2, ARSH
17androstenedione44 2412.9ESR2, GNRH1, SERPINA6, CYP1A1, CYP19A1, CYP1B1
18progestin4411.9GNRH1, ARSH, STS, VEGFA, CYP19A1, PGR
19cyclophosphamide44 49 1113.9IL11, HGF, PGR, CYP1B1, CYP19A1, CYP1A1
20paclitaxel44 49 1113.9CYP19A1, CYP1B1, VEGFA, PGR, IL11, HGF
21mifepristone44 59 28 1114.7CYP19A1, VEGFA, PGR, SERPINA6, ESR2, GNRH1
22toremifene44 1112.6CYP19A1, ESR2, GNRH1, CYP1A1, PGR
23tibolone4411.6STS, ARSH, PGR, GNRH1, CYP19A1
24danazol44 11 2413.6PGR, CYP19A1, STS, ARSH, GNRH1
25letrozole44 49 59 1114.6PGR, ESR2, CYP1B1, CYP19A1, STS
26dmso4411.6GNRH1, ESR2, PGR, HGF, CYP1B1, CYP1A1
27flutamide44 59 1113.6GNRH1, CYP1A1, CYP19A1, CYP1B1, PGR
28estrone sulfate44 2412.6ARSH, STS, PGR, CYP1B1, CYP19A1
295fluorouracil4411.5PGR, HGF, IL11, GNRH1, CYP1B1
30diethylstilbestrol44 28 1113.5PGR, ESR2, FST, GNRH1, CYP19A1
31dhea4411.5CYP19A1, ARSH, STS, SERPINA6, ESR2
32gnrh4411.4ESR2, FST, PGR, CYP19A1, ARSH, GNRH1
33gefitinib44 49 1113.4HGF, VEGFA, CYP1A1, CYP19A1, ESR2
34nandrolone44 2412.4ESR2, CYP19A1, PGR, SERPINA6
35estradiol benzoate4411.4GNRH1, ESR2, PGR, CYP19A1
36dehydroepiandrosterone sulfate4411.4STS, SERPINA6, CYP19A1, GNRH1
37leuprolide acetate4411.4GNRH1, CYP19A1, PGR, ESR2
38exemestane49 44 59 1114.3ESR2, PGR, CYP19A1, CYP1B1
39ribonucleic acid4411.3ESR2, SERPINA6, FST, IL11, PGR, GNRH1
40bisphenol a4411.3PGR, ESR2, CYP19A1, ARSH
41clomiphene citrate4411.3ESR2, GNRH1, PGR, CYP19A1
42fulvestrant44 49 28 1114.3ESR2, CYP1A1, PGR, CYP19A1
43cyproteroneacetate4411.2PGR, GNRH1, SERPINA6, CYP19A1
44levonorgestrel44 59 28 1114.1SERPINA6, CYP19A1, PGR, ESR2
45norelgestromin44 1112.1STS, PGR, ARSH
46estrogen4411.1ARSH
4717-hydroxyprogesterone44 2412.0SERPINA6, CYP19A1, MUC16, GNRH1
48cycloheximide4411.0HGF
49dydrogesterone28 44 1112.8STS, PGR, ARSH
50promegestone44 2811.6PGR, STS, ARSH

GO Terms for genes affiliated with Endometriosis

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Sources:
16Gene Ontology
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Cellular components related to Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3SERPINA6, IL11, MUC16, VEGFA, GNRH1, HGF

Biological processes related to Endometriosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:00820211.1CYP1B1, CYP19A1, HSD17B1
2positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0IL11, VEGFA, HGF
3cell-cell signalingGO:00726710.9GNRH1, PGR, IL11, ESR2
4omega-hydroxylase P450 pathwayGO:09726710.8CYP1A1, CYP1B1
5estrogen biosynthetic processGO:00670310.8HSD17B1, CYP19A1
6sterol metabolic processGO:01612510.8CYP1B1, CYP19A1
7epoxygenase P450 pathwayGO:01937310.5CYP1B1, CYP1A1

Molecular functions related to Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aromatase activityGO:07033010.9CYP1B1, CYP19A1, CYP1A1
2steroid bindingGO:00549610.8PGR, SERPINA6, ESR2
3oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.8CYP1B1, CYP19A1
4oxygen bindingGO:01982510.6CYP1B1, CYP19A1, CYP1A1

Products for genes affiliated with Endometriosis

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  • Antibodies
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Sources for Endometriosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet