MCID: END044
MIFTS: 71

Endometriosis

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Endometriosis

MalaCards integrated aliases for Endometriosis:

Name: Endometriosis 12 72 36 28 51 40 41 14 69 59

Classifications:



External Ids:

Disease Ontology 12 DOID:289
ICD10 32 N80 N80.9
ICD9CM 34 617 617.9
MeSH 41 D004715
NCIt 46 C3014
KEGG 36 H01639
UMLS 69 C0014175

Summaries for Endometriosis

PubMed Health : 59
About endometriosis: Endometriosis is one of the most common medical conditions affecting the abdomen (lower belly) in women. In endometriosis, the kind of tissue that normally lines the inside of the womb (endometrial tissue) also grows outside of it. The medical term for endometrial tissue that has grown outside of the womb is “endometrial implants.” Some women have them without knowing it. But other women experience endometriosis as a chronic disease that causes severe pain and fertility problems. It often takes years for endometriosis to be diagnosed as the cause of these problems. Until the diagnosis is made, many women try to cope with their pain somehow. They believe that the pain – even really bad pain – is a normal part of their menstrual period.There is currently no cure for endometriosis. But there are many things that can be done to relieve the symptoms. If treatment is adapted to suit women’s personal circumstances and the severity of their endometriosis, many can cope quite well with the disease.Like with other chronic conditions, it's important to get to know your own body and how it reacts, in order to find ways to manage the symptoms. Getting hold of good information and consulting experienced, supportive doctors can help.

MalaCards based summary : Endometriosis is related to endometriosis of ovary and adenomyosis, and has symptoms including pain and other symptoms associated with female genital organs and pelvic pain. An important gene associated with Endometriosis is ENDO1 (Endometriosis, Susceptibility To, 1), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. The drugs Calcium Carbonate and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and endothelial, and related phenotypes are endocrine/exocrine gland and integument

MedlinePlus : 40 The uterus, or womb, is the place where a baby grows when a woman is pregnant. Endometriosis is a disease in which the kind of tissue that normally grows inside the uterus grows outside the uterus. It can grow on the ovaries, fallopian tubes, bowels, or bladder. Rarely, it grows in other parts of the body. Symptoms include Pain, usually in the abdomen, lower back, or pelvic areas Infertility Heavy periods and bleeding between periods Painful menstrual cramps Some women have no symptoms at all. Having trouble getting pregnant may be the first sign. The cause of endometriosis is not known. Surgery, usually a laparoscopy, is currently the only way to be sure that you have endometriosis. Your health care provider will first take your medical history, do a pelvic exam, and maybe do imaging tests. There is no cure, but treatments help with pain and infertility. They include pain medicines, hormone treatments, and surgery. NIH: National Institute of Child Health and Human Development

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.

Wikipedia : 72 Endometriosis is a condition in which the layer of tissue that normally covers the inside of the uterus... more...

Related Diseases for Endometriosis

Diseases in the Endometriosis family:

Endometriosis 1 Rare Endometriosis

Diseases related to Endometriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
# Related Disease Score Top Affiliating Genes
1 endometriosis of ovary 34.2 CYP19A1 ESR1 ESR2 PGR
2 adenomyosis 33.7 ESR1 PGR VEGFA
3 uterine anomalies 31.9 CXCL8 CYP19A1 ESR1 IL1B IL6
4 peritonitis 31.7 CCL2 CXCL8 IL1B IL6
5 infertility 31.4 CYP19A1 ESR2 GNRH1 NR5A1 PGR
6 progesterone resistance 31.0 ESR1 ESR2 PGR
7 ovarian cancer 1 31.0 ESR1 PGR VEGFA
8 leiomyomatosis 31.0 ESR1 GNRH1 PGR
9 endometrial stromal sarcoma 31.0 CCL2 CXCL8 CYP19A1 ESR1 PGR
10 leiomyoma 30.8 CYP19A1 ESR1 ESR2 GNRH1 PGR
11 myoma 30.7 CYP19A1 ESR1 GNRH1 PGR
12 vaginitis 30.7 CXCL8 ESR1 ESR2 IL1B IL6
13 appendicitis 30.4 CXCL8 IL1B IL6
14 leiomyoma, uterine 30.4 CYP19A1 ESR1 ESR2 GNRH1 PGR
15 prostatitis 30.2 CXCL8 IL1B IL6
16 endometritis 30.2 ESR1 IL1B IL6 PGR
17 ovarian serous cystadenocarcinoma 30.2 ESR2 PGR VEGFA
18 serous cystadenocarcinoma 30.2 ESR2 PGR VEGFA
19 cystadenocarcinoma 30.2 ESR2 PGR VEGFA
20 primary peritoneal carcinoma 30.2 CXCL8 PGR VEGFA
21 ovarian hyperstimulation syndrome 30.2 CYP19A1 GNRH1 VEGFA
22 endometrial adenocarcinoma 30.1 ESR1 ESR2 PAEP PGR VEGFA
23 breast disease 30.0 ESR1 ESR2 PGR
24 intestinal disease 29.9 CXCL8 IL1B IL6
25 pyelonephritis 29.9 CCL2 CXCL8 IL1B IL6
26 chorioamnionitis 29.9 CCL2 CXCL8 IL1B IL6
27 endometrial disease 29.8 CXCL8 CYP19A1 ESR1 IL1B IL6
28 endometriosis of uterus 12.2
29 fallopian tube endometriosis 12.2
30 cervix endometriosis 12.1
31 rare endometriosis 12.0
32 endometriosis of intestine 12.0
33 endometriosis of pelvic peritoneum 12.0
34 endometriosis in scar of skin 12.0
35 endometriosis of rectovaginal septum and vagina 12.0
36 endometriosis 1 11.9
37 catamenial pneumothorax 11.6
38 chronic pain 11.2
39 benign multicystic peritoneal mesothelioma 10.9
40 vulvar syringoma 10.7 ESR1 PGR
41 vestibular gland benign neoplasm 10.7 ESR1 PGR
42 lung leiomyoma 10.7 ESR1 PGR
43 bartholin's gland adenoma 10.7 ESR1 PGR
44 glassy cell carcinoma of the cervix 10.7 ESR1 PGR
45 vulvar benign neoplasm 10.7 ESR1 PGR
46 trigonitis 10.7 ESR1 PGR
47 vulvar leiomyoma 10.7 ESR1 PGR
48 mammographic density 10.7 CYP19A1 ESR1 PGR
49 prostatic hypertrophy 10.7 CYP19A1 ESR1 PGR
50 fallopian tube carcinoma 10.7 ESR1 PGR VEGFA

Comorbidity relations with Endometriosis via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to Endometriosis

Symptoms & Phenotypes for Endometriosis

UMLS symptoms related to Endometriosis:


pain and other symptoms associated with female genital organs, pelvic pain

MGI Mouse Phenotypes related to Endometriosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.06 IL6 CYP19A1 NR5A1 ESR1 PGR ESR2
2 integument MP:0010771 9.91 IL1B IL6 CYP19A1 ESR1 PGR ESR2
3 neoplasm MP:0002006 9.76 AHRR IL6 ESR1 PGR ESR2 GNRH1
4 reproductive system MP:0005389 9.7 IL6 CYP19A1 NR5A1 ESR1 PGR ESR2
5 skeleton MP:0005390 9.32 IL1B IL6 CYP19A1 ESR1 PGR ESR2

Drugs & Therapeutics for Endometriosis

PubMedHealth treatment related to Endometriosis: 59

There is currently no “cure” for endometriosis – in other words, there are no treatments that can fight what is causing it. But various treatments can help relieve the symptoms, temporarily or permanently. The medication options include painkillers, hormonal contraception and stronger hormone therapy. Painkillers only relieve the symptoms, whereas hormone-based treatments slow down the growth of endometrial implants.Surgery is also an option. The aim of surgery for endometriosis is usually to remove as many endometrial implants as possible. Sometimes surgery is even necessary – for instance, if endometriosis is affecting bowel or bladder function.

Drugs for Endometriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 256)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Goserelin Approved Phase 4,Phase 3 65807-02-5 5311128 47725
3
Tibolone Approved, Investigational Phase 4 5630-53-5
4
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-28-2 5757
6
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 657181 3911
7
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
8
Drospirenone Approved Phase 4,Phase 3 67392-87-4 68873
9
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2 57-63-6 5991
10
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1 120511-73-1 2187
11
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 57-83-0 5994
12
Ethanol Approved Phase 4 64-17-5 702
13
Desogestrel Approved Phase 4 54024-22-5 40973
14
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 6917715 40976
15
Gestodene Approved, Investigational Phase 4 60282-87-3 3033968
16
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 1 71-58-9
17
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
18
Danazol Approved Phase 4,Phase 2 17230-88-5 28417
19
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
20
Quinagolide Approved, Investigational Phase 4 87056-78-8, 97805-50-0 105105
21
Dienogest Approved Phase 4,Phase 3,Phase 2 65928-58-7
22
Nandrolone Approved, Experimental, Illicit, Investigational Phase 4,Phase 3,Phase 2 62-90-8, 434-22-0 9904 229455
23
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3,Phase 2 360-70-3 9677
24
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
25
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
26
Norgestrel Approved Phase 4 6533-00-2 13109
27
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
29
Norepinephrine Approved Phase 4 51-41-2 439260
30
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
31
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
32
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
33
Sage Approved, Nutraceutical Phase 4
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
35 tannic acid Approved, Nutraceutical Phase 4,Phase 3
36 Gallopamil Investigational Phase 4 16662-47-8
37
Enclomiphene Investigational Phase 4 15690-57-0
38 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
39 Bone Density Conservation Agents Phase 4,Phase 2
40 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
43 Micronutrients Phase 4,Phase 3,Phase 2
44 Trace Elements Phase 4,Phase 3,Phase 2
45 Vitamins Phase 4,Phase 2
46 Adjuvants, Immunologic Phase 4
47 Protective Agents Phase 4,Phase 3,Phase 2
48 Viscosupplements Phase 4
49 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Contraceptives, Oral Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 344)

# Name Status NCT ID Phase Drugs
1 Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis Unknown status NCT00654524 Phase 4 gonadotropin-releasing-hormone agonist (GnRHa) - Goserelin
2 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
3 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4 Continuous OC (clormadinone acetate plus ethinil-estradiol - Belara®, Grunenthal, Milan, Italy);Cyclic OC (clormadinone acetate plus ethinil-estradiol)
4 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
5 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4 Sanjie analgesic capsule;placebo
6 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
7 Supplementation in Adolescent Girls With Endometriosis Completed NCT02387931 Phase 4
8 Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence Completed NCT01769781 Phase 4 anastrazole;GnRH analog alone
9 Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis Completed NCT02158845 Phase 4 LNG-IUS: levonorgestrel intrauterine system;GnRHa: leuprolide
10 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed NCT01682642 Phase 4 Zoladex
11 Homeopathic Treatment of Chronic Pelvic Pain in Women With Endometriosis Completed NCT02427386 Phase 4 dynamized estrogen;placebo
12 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Completed NCT02480647 Phase 4 Levonorgestrel;Etonogestrel
13 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4 Leuprolide acetate in depot suspension;Leuprolide acetate;leuprolide acetate
14 The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis Completed NCT01581359 Phase 4 Triptorelin acetate
15 Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain Completed NCT01056042 Phase 4 intramuscular depot medroxyprogesterone acetate;ethinyl estradiol 30 micrograms, gestodene 75 micrograms
16 Resveratrol for Pain Due to Endometriosis Completed NCT02475564 Phase 4 Placebo;Resveratrol
17 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4 Danazol;placebo
18 Endometriosis Patients Undergoing Quinagolide Treatment Completed NCT00625950 Phase 4
19 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
20 Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients Completed NCT02534688 Phase 4 LNG-IUS;DMPA
21 Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women Completed NCT00735852 Phase 4 Decapeptyl SR 11.25mg
22 Impact of Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
23 Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving Recruiting NCT03080558 Phase 4 Indocyanine green
24 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest Recruiting NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
25 Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery Recruiting NCT02385448 Phase 4 Dienogest;Microgynon
26 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
27 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4 Rocuronium
28 Ulipristal for Endometriosis-related Pelvic Pain Active, not recruiting NCT02213081 Phase 4 Ulipristal
29 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4 Combined Oral Contraceptive Pill (Microgynon 30)
30 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
31 Duloxetine for the Treatment of Chronic Pelvic Pain Terminated NCT01451606 Phase 4 Duloxetine;Placebo
32 Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery Unknown status NCT01125488 Phase 3 GnRH agonist (triptorelin)
33 Laparoscopy Versus Laparotomy for Colorectal Endometriosis Unknown status NCT00939861 Phase 3
34 Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) Unknown status NCT00458458 Phase 3 Norethindrone Acetate (NA);GnRH Agonist (Lupron Depot)
35 The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study Unknown status NCT00894946 Phase 3
36 The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol Unknown status NCT01636505 Phase 3 ghrh antagonist (cetrotide/orgalutran);gnrh agonist (suprefact)
37 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
38 Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients Completed NCT01822080 Phase 3 Dienogest (Visanne, BAY86-5258);Placebo
39 Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis Completed NCT02271958 Phase 2, Phase 3 Mifepristone;PLACEBO
40 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-associated Pain Completed NCT02143713 Phase 3 Elagolix
41 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01931670 Phase 3 Elagolix
42 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01620528 Phase 3 Elagolix
43 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01760954 Phase 3 Elagolix
44 Degarelix in the Treatment of Endometriosis Recurrence Completed NCT01712763 Phase 3 degarelix;goserelin
45 Comparative Study of BAY86-5300 With an Extended Flexible Regimen for Endometriosis Completed NCT01697111 Phase 3 EE20/DRSP(BAY86-5300);Placebo;Dienogest
46 Pentoxifylline and Endometriosis Completed NCT00632697 Phase 3 pentoxifylline;placebo
47 Medical Treatment of Endometriosis-Associated Pelvic Pain Completed NCT00229996 Phase 3 Oral Contraceptive;Depot-Leuprolide/Norethindrone
48 Safety and Efficacy of SH T00660AA in Treatment of Endometriosis Completed NCT00225186 Phase 3 Visanne (SH T00660AA , BAY86-5258)
49 Efficacy and Safety of SH T00660AA in Treatment of Endometriosis Completed NCT00225199 Phase 3 Visanne (BAY86-5258, SH T00660AA);Placebo
50 The Effectiveness of Lng IUD for Treatment of the Patient Undergone Conservative Surgery for Pelvic Endometriosis Completed NCT00455845 Phase 3

Search NIH Clinical Center for Endometriosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: endometriosis

Genetic Tests for Endometriosis

Genetic tests related to Endometriosis:

# Genetic test Affiliating Genes
1 Endometriosis 28

Anatomical Context for Endometriosis

MalaCards organs/tissues related to Endometriosis:

38
Uterus, Ovary, Endothelial, Testes, Monocytes, Smooth Muscle, Neutrophil

Publications for Endometriosis

Articles related to Endometriosis:

(show top 50) (show all 2652)
# Title Authors Year
1
Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. ( 29304094 )
2018
2
Appendiceal Endometriosis and Ectopic Pregnancy Occurring Simultaneously. ( 29420399 )
2018
3
Endometriosis: clinical features, MR imaging findings and pathologic correlation. ( 29450853 )
2018
4
Authors' reply re: Medical therapy for preventing recurrent endometriosis after conservative surgery: a cost-effectiveness analysis. ( 29446239 )
2018
5
Medical treatment in the management of deep endometriosis infiltrating the proximal rectum and sigmoid colon: a comprehensive literature review. ( 29431849 )
2018
6
Caloric Restriction Dramatically Stalls Lesion Growth in Mice With Induced Endometriosis. ( 29439622 )
2018
7
Circulating Neutrophil Extracellular Traps Are Elevated in Patients With Deep Infiltrating Endometriosis. ( 29448896 )
2018
8
Ileocecal intussusception extending to left colon due to endometriosis. ( 29364012 )
2018
9
Co-existence of benign gynecological tumors with endometriosis in a group of 1,000 women. ( 29434846 )
2018
10
Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States. ( 29450864 )
2018
11
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
12
Conservative Management of Ovarian Fibroma in A Case of Gorlin-Goltz Syndrome Comorbid with Endometriosis. ( 29334213 )
2018
13
Integrating the dysregulated inflammasome-based molecular functionome in the malignant transformation of endometriosis-associated ovarian carcinoma. ( 29423077 )
2018
14
Endometriosis increased the risk of bladder pain syndrome/interstitial cystitis: A population-based study. ( 29318645 )
2018
15
Endometriosis alters brain electro-physiology, gene expression and increased pain sensitization, anxiety, and depression in female mice. ( 29425272 )
2018
16
Four Case Reports of Endometriosis-Related Hemoperitoneum in Pregnancy. ( 29451162 )
2018
17
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. ( 29450941 )
2018
18
Endometriosis: a rare cause of multiple lung nodules on imaging. ( 29431501 )
2018
19
Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. ( 29428309 )
2018
20
Ileocecal endometriosis as an infrequent cause of intussusception. ( 29278003 )
2018
21
Laparoscopic surgery with urinary tract reconstruction and bowel endometriosis resection for deep infiltrating endometriosis. ( 29444547 )
2018
22
Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? ( 29383437 )
2018
23
Hypoxia Promotes Ectopic Adhesion Ability of Endometrial Stromal Cells via TGF-I^1/Smad Signalling in Endometriosis. ( 29438550 )
2018
24
Effect of Mst1 on Endometriosis Apoptosis and Migration: Role of Drp1-Related Mitochondrial Fission and Parkin-Required Mitophagy. ( 29448246 )
2018
25
SR-16234, a Novel Selective Estrogen Receptor Modulator for Pain Symptoms with Endometriosis: An Open-label Clinical Trial. ( 29434492 )
2017
26
Androgen receptor cytosine, adenine, and guanine trinucleotide repeat polymorphism in Korean patients with endometriosis: A case-control study. ( 28915409 )
2017
27
Reply to Rodolfo Montironi, Silvia Gasparrini, Antonio Lopez-Beltran, et al's Letter to the Editor re: Umberto Leone Roberti Maggiore, Simone Ferrero, Massimo Candiani, et al. Bladder Endometriosis: A Systematic Review of Pathogenesis, Diagnosis, Treatment, Impact on Fertility, and Risk of Malignant Transformation. Eur Urol 2017;71:790-807. Benign MA1llerian Lesions in the Urinary Bladder: Endometriosis, Endocervicosis, Endosalpingiosis, and MA1llerianosis. ( 28583309 )
2017
28
Evaluation of Circulating Endometrial Cells as a Biomarker for Endometriosis. ( 28937041 )
2017
29
Does preoperative antimA1llerian hormone level influence postoperative pregnancy rate in women undergoing surgery for severe endometriosis? ( 28089574 )
2017
30
Early endometriosis in females is directed by immune-mediated estrogen receptor alpha and IL6 cross-talk. ( 28927243 )
2017
31
Management of ureteral endometriosis with hydronephrosis: Experience from a tertiary medical center. ( 28707816 )
2017
32
Baicalein reduces endometriosis by suppressing the viability of human endometrial stromal cells through the nuclear factor-I_B pathway in vitro. ( 28912852 )
2017
33
Extrauterine Adenomyoma of the Liver in a 50 year old Female with Pelvic Endometriosis. ( 28442524 )
2017
34
Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma. ( 28930811 )
2017
35
Long non-coding RNA LINC00261 inhibits cell growth and migration in endometriosis. ( 28707780 )
2017
36
Combined effect of vascular endothelial growth factor and its receptor polymorphisms in endometriosis: a case-control study. ( 27836223 )
2017
37
Aberrant Expression of lncRNA ( HOXA11-AS1) and Homeobox A ( HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women With Endometriosis. ( 29017417 )
2017
38
Catamenial pneumothorax revealing diaphragmatic endometriosis: a case report and revue of literature. ( 28819533 )
2017
39
Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. ( 28624114 )
2017
40
Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. ( 27729562 )
2017
41
Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial. ( 28950844 )
2017
42
Thoracic endometriosis syndrome: association with pelvic endometriosis and fertility status. ( 28069481 )
2017
43
Aberrant endometrial DNA methylome of homeobox A10 and catechol-O-methyltransferase in endometriosis. ( 28074437 )
2017
44
Progesterone resistance in endometriosis: origins, consequences and interventions. ( 28423456 )
2017
45
Oral and depot progestin therapy for endometriosis: towards a personalized medicine. ( 28914561 )
2017
46
IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORI^t/Blimp-1 signal to promote the progression of endometriosis. ( 28300844 )
2017
47
Anisakiasis and intestinal endometriosis: under-recognized conditions in the differential diagnosis of acute abdomen. ( 28004963 )
2017
48
Smad3/4 Binding to Promoter II of P450arom So As to Regulate Aromatase Expression in Endometriosis. ( 27920344 )
2017
49
Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women. ( 28925754 )
2017
50
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2017

Variations for Endometriosis

Expression for Endometriosis

LifeMap Discovery
Genes differentially expressed in tissues of Endometriosis patients vs. healthy controls: 35 (show top 50) (show all 83)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PTGIS prostaglandin I2 (prostacyclin) synthase Uterus + 5.41 0.000
2 MYH11 myosin, heavy chain 11, smooth muscle Uterus + 4.87 0.001
3 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide Uterus + 4.81 0.000
4 CNN1 calponin 1, basic, smooth muscle Uterus + 4.71 0.000
5 TAGLN transgelin Uterus + 4.63 0.000
6 PAEP progestagen-associated endometrial protein Uterus + 4.63 0.013
7 PRELP proline/arginine-rich end leucine-rich repeat protein Uterus + 4.59 0.000
8 C7 complement component 7 Uterus + 4.54 0.003
9 ACTG2 actin, gamma 2, smooth muscle, enteric Uterus + 4.48 0.003
10 TCF21 transcription factor 21 Uterus + 4.45 0.000
11 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 4.42 0.001
12 WISP2 WNT1 inducible signaling pathway protein 2 Uterus + 4.11 0.001
13 AQP1 aquaporin 1 (Colton blood group) Uterus + 4.10 0.000
14 EHF ets homologous factor Uterus - 4.10 0.000
15 FOS FBJ murine osteosarcoma viral oncogene homolog Uterus + 4.09 0.000
16 FOSB FBJ murine osteosarcoma viral oncogene homolog B Uterus + 4.07 0.000
17 SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 Uterus - 4.05 0.010
18 LMNB1 lamin B1 Uterus - 4.05 0.000
19 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.99 0.000
20 DPT dermatopontin Uterus + 3.98 0.000
21 DES desmin Uterus + 3.97 0.001
22 KCNMB1 potassium channel subfamily M regulatory beta subunit 1 Uterus + 3.96 0.001
23 GATA6 GATA binding protein 6 Uterus + 3.89 0.004
24 FZD7 frizzled class receptor 7 Uterus + 3.89 0.000
25 LEFTY2 left-right determination factor 2 Uterus + 3.88 0.001
26 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.87 0.001
27 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 3.86 0.001
28 ACKR1 atypical chemokine receptor 1 (Duffy blood group) Uterus + 3.84 0.001
29 EFHC2 EF-hand domain (C-terminal) containing 2 Uterus - 3.75 0.000
30 PDLIM3 PDZ and LIM domain 3 Uterus + 3.72 0.001
31 GPC3 glypican 3 Uterus + 3.71 0.003
32 IL20RA interleukin 20 receptor, alpha Uterus - 3.70 0.000
33 MYL9 myosin, light chain 9, regulatory Uterus + 3.70 0.001
34 VNN1 vanin 1 Uterus - 3.69 0.008
35 CTSZ cathepsin Z Uterus - 3.68 0.000
36 EHF ets homologous factor Uterus - 3.67 0.000
37 LMNB1 lamin B1 Uterus - 3.61 0.000
38 CLU clusterin Uterus + 3.58 0.002
39 ACTA2 actin, alpha 2, smooth muscle, aorta Uterus + 3.57 0.000
40 TCEAL2 transcription elongation factor A (SII)-like 2 Uterus + 3.53 0.001
41 LMOD1 leiomodin 1 (smooth muscle) Uterus + 3.52 0.003
42 LMO3 LIM domain only 3 (rhombotin-like 2) Uterus + 3.51 0.002
43 TPD52 tumor protein D52 Uterus - 3.50 0.000
44 SYNPO synaptopodin Uterus + 3.48 0.001
45 KLF2 Kruppel-like factor 2 Uterus + 3.44 0.000
46 AOC3 amine oxidase, copper containing 3 Uterus + 3.44 0.003
47 KCNK3 potassium channel, two pore domain subfamily K, member 3 Uterus + 3.44 0.007
48 ZBBX zinc finger, B-box domain containing Uterus - 3.43 0.001
49 FMO1 flavin containing monooxygenase 1 Uterus + 3.43 0.000
50 ZBBX zinc finger, B-box domain containing Uterus - 3.42 0.002
Search GEO for disease gene expression data for Endometriosis.

Pathways for Endometriosis

Pathways related to Endometriosis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CCL2 CXCL8 ESR1 ESR2 GNRH1 IL1B
2 12.75 CXCL8 ESR1 ESR2 IL6 VEGFA
3
Show member pathways
12.24 CCL2 CXCL8 IL1B IL6
4 12.17 CXCL8 HOXA10 IL1R2 IL6
5 12.04 CXCL8 ESR2 IL1B IL6 VEGFA
6 11.99 CCL2 IL1B IL1R2 VEGFA
7 11.9 CCL2 CXCL8 IL1B IL6
8 11.82 CCL2 CXCL8 IL1B IL6 VEGFA
9 11.79 CXCL8 IL1B IL1R2 IL6
10
Show member pathways
11.75 ESR1 ESR2 NR5A1 PGR
11 11.74 CXCL8 IL1B IL6
12 11.72 CCL2 CXCL8 IL1B IL6 VEGFA
13 11.67 CXCL8 IL1B IL6
14 11.58 CCL2 CXCL8 IL1B IL6
15
Show member pathways
11.56 CXCL8 IL1B IL6 VEGFA
16 11.51 CXCL8 IL1B IL6
17 11.51 CCL2 CXCL8 IL1B IL6 VEGFA
18 11.47 CXCL8 IL6 VEGFA
19 11.43 AHRR ESR1 VEGFA
20 11.4 CCL2 CXCL8 IL1B IL6
21 11.39 CYP19A1 IL1B IL6
22 11.24 CCL2 CXCL8 IL6
23 11.14 CCL2 CXCL8 IL1B IL6
24 11.06 CYP19A1 ESR2 NR5A1 PGR
25 11.04 CCL2 CXCL8 IL1B IL1R2 IL6
26 10.7 IL1B IL6
27 10.27 CYP19A1 HSD17B1
28 9.53 CYP19A1 ESR1 ESR2 HSD17B1

GO Terms for Endometriosis

Cellular components related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 CCL2 CXCL8 ESR2 GNRH1 IL1B IL1R2

Biological processes related to Endometriosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CCL2 CXCL8 IL1B IL1R2 IL6
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.78 ESR1 ESR2 NR5A1 PGR
3 cell-cell signaling GO:0007267 9.77 ESR2 GNRH1 IL1B NR5A1 PGR
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 AHRR ESR1 HOXA10 IL1B IL6 NR5A1
5 cytokine-mediated signaling pathway GO:0019221 9.73 CCL2 IL1B IL1R2 IL6
6 regulation of receptor activity GO:0010469 9.73 CCL2 CXCL8 GNRH1 IL1B IL6 VEGFA
7 neutrophil chemotaxis GO:0030593 9.67 CCL2 CXCL8 IL1B
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.62 ESR1 ESR2 IL1B IL6
9 induction of positive chemotaxis GO:0050930 9.56 CXCL8 VEGFA
10 estrogen biosynthetic process GO:0006703 9.55 CYP19A1 HSD17B1
11 PERK-mediated unfolded protein response GO:0036499 9.54 CCL2 CXCL8
12 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.51 IL1B PAEP
13 testosterone biosynthetic process GO:0061370 9.46 CYP19A1 HSD17B1
14 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.4 IL1R2 IL6
15 uterus development GO:0060065 9.13 CYP19A1 ESR1 HOXA10
16 steroid hormone mediated signaling pathway GO:0043401 8.92 ESR1 ESR2 NR5A1 PGR

Molecular functions related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 CCL2 CXCL8 IL1B IL6 VEGFA
2 steroid hormone receptor activity GO:0003707 9.46 ESR1 ESR2 NR5A1 PGR
3 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
4 estrogen response element binding GO:0034056 9.37 ESR1 ESR2
5 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.32 ESR1 ESR2
6 nuclear receptor activity GO:0004879 9.26 ESR1 ESR2 NR5A1 PGR
7 steroid binding GO:0005496 8.92 ESR1 ESR2 HSD17B1 PGR

Sources for Endometriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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