MCID: END044
MIFTS: 66

Endometriosis malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Endometriosis

Aliases & Descriptions for Endometriosis:

Name: Endometriosis 12 29 52 41 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:289
ICD10 33 N80 N80.9
ICD9CM 35 617 617.9
MeSH 42 D004715
NCIt 47 C3014
UMLS 69 C0014175

Summaries for Endometriosis

MedlinePlus : 41 the uterus, or womb, is the place where a baby grows when a woman is pregnant. endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus. it can grow on the ovaries, fallopian tubes, bowels, or bladder. rarely, it grows in other parts of the body. symptoms include pain, usually in the abdomen, lower back, or pelvic areas infertility heavy periods and bleeding between periods painful menstrual cramps some women have no symptoms at all. having trouble getting pregnant may be the first sign. the cause of endometriosis is not known. surgery, usually a laparoscopy, is currently the only way to be sure that you have endometriosis. your health care provider will first take your medical history, do a pelvic exam, and maybe do imaging tests. there is no cure, but treatments help with pain and infertility. they include pain medicines, hormone treatments, and surgery. nih: national institute of child health and human development

MalaCards based summary : Endometriosis is related to endocervicitis and tuberculosis, and has symptoms including pelvic pain and pain and other symptoms associated with female genital organs. An important gene associated with Endometriosis is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and IL-17 Family Signaling Pathways. The drugs Estradiol and Tibolone have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and endothelial, and related phenotypes are endocrine/exocrine gland and integument

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.

Wikipedia : 71 Endometriosis is a condition in which tissue that normally grows inside the uterus (endometrium) grows... more...

Related Diseases for Endometriosis

Diseases in the Endometriosis family:

Endometriosis 1 Rare Endometriosis

Diseases related to Endometriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
id Related Disease Score Top Affiliating Genes
1 endocervicitis 30.2 ESR2 PGR VEGFA
2 tuberculosis 29.8 CCL2 IL1B IL6
3 neuropathy 29.6 CXCL8 IL1B IL6
4 colon adenocarcinoma 29.5 CXCL8 IL1B IL6
5 endometriosis of ovary 12.2
6 fallopian tube endometriosis 12.0
7 endometriosis of uterus 12.0
8 rare endometriosis 11.9
9 endometriosis of intestine 11.8
10 endometriosis of pelvic peritoneum 11.8
11 endometriosis of rectovaginal septum and vagina 11.8
12 cervix endometriosis 11.8
13 endometriosis in scar of skin 11.8
14 endometriosis 1 11.8
15 adenomyosis 11.7
16 catamenial pneumothorax 11.4
17 chronic pain 11.1
18 benign multicystic peritoneal mesothelioma 10.8
19 uterine disease 10.8
20 peritonitis 10.6
21 infertility 10.5
22 bartholin's gland benign neoplasm 10.4 ESR1 PGR
23 cardiovascular organ benign neoplasm 10.4 ESR1 PGR
24 appendix leiomyoma 10.4 ESR1 PGR
25 bronchus adenoma 10.4 ESR1 PGR
26 glioma 10.4 ESR1 PGR
27 deafness, autosomal recessive 21 10.4 ESR1 ESR2 PGR
28 adult neuronal ceroid lipofuscinosis 10.4 ESR1 PGR VEGFA
29 adams-oliver syndrome 6 10.4 CYP19A1 ESR1 GNRH1
30 esophagus sarcoma 10.4 CYP19A1 ESR1 PGR
31 fallopian tube carcinosarcoma 10.4 ESR1 PGR VEGFA
32 capillary disease 10.4 CYP19A1 ESR1 PGR
33 ovarian benign neoplasm 10.4 ESR1 PGR
34 epithelioid neurofibroma 10.4 ESR1 GNRH1 PGR
35 plexiform neurofibroma 10.4 ESR1 PGR
36 breast duct papilloma 10.4 CYP19A1 ESR1 PGR
37 peeling skin syndrome 10.4 ESR1 ESR2 PGR
38 cryptosporidiosis 10.4 CCL2 IL6 VEGFA
39 her2-receptor negative breast cancer 10.4 CYP19A1 ESR1 ESR2 PGR
40 osteogenesis imperfecta 10.4 CYP19A1 ESR1 ESR2 PGR
41 acute thyroiditis 10.4 CYP19A1 ESR1 ESR2 PGR
42 glycerol kinase deficiency, adult form 10.4 CYP19A1 ESR1 PGR VEGFA
43 perinatal jaundice due to hepatocellular damage 10.4 CYP19A1 ESR1 ESR2 PGR
44 her2-receptor positive breast cancer 10.4 CXCL8 ESR1 PGR
45 haverhill fever 10.4 CYP19A1 ESR1 GNRH1 PGR
46 pyriform sinus cancer 10.4 CCL2 IL6 VEGFA
47 kidney benign neoplasm 10.4 ESR2 PGR VEGFA
48 nephrogenic adenofibroma 10.4 CYP19A1 ESR1 GNRH1 PGR
49 progesterone-receptor negative breast cancer 10.4 CYP19A1 ESR1 PGR
50 ulcerative proctitis 10.4 CCL2 CXCL8 VEGFA

Comorbidity relations with Endometriosis via Phenotypic Disease Network (PDN):


Uterine Fibroid

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to Endometriosis

Symptoms & Phenotypes for Endometriosis

UMLS symptoms related to Endometriosis:


pelvic pain, pain and other symptoms associated with female genital organs

MGI Mouse Phenotypes related to Endometriosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.11 IL6 NR5A1 PGR RXFP1 VEGFA CYP19A1
2 integument MP:0010771 9.97 IL6 PGR RXFP1 VEGFA CYP19A1 ESR1
3 neoplasm MP:0002006 9.86 AHRR ESR1 ESR2 GNRH1 IL1B IL6
4 renal/urinary system MP:0005367 9.7 CYP19A1 ESR1 ESR2 GNRH1 HSD17B1 IL6
5 reproductive system MP:0005389 9.7 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 HSD17B1
6 skeleton MP:0005390 9.32 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 IL1B

Drugs & Therapeutics for Endometriosis

Drugs for Endometriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 250)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-28-2 5757 53477783
2
Tibolone Approved Phase 4 5630-53-5
3
Goserelin Approved Phase 4,Phase 3 65807-02-5 47725 5311128
4
Drospirenone Approved Phase 4,Phase 3 67392-87-4 68873
5
Calcium carbonate Approved Phase 4 471-34-1
6
Desogestrel Approved Phase 4 54024-22-5 40973
7
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
8
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 3911 657181
9
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2 57-63-6 5991
10
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
11
Ethanol Approved Phase 4 64-17-5 702
12
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
13
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 57-83-0 5994
14
Gestodene Approved Phase 4 60282-87-3 3033968
15
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3,Phase 2 360-70-3 9677
16
Nandrolone Approved, Experimental, Illicit Phase 4,Phase 3,Phase 2 434-22-0, 62-90-8 9904 229455
17
Danazol Approved Phase 4,Phase 2 17230-88-5 28417
18
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1 120511-73-1 2187
19
Quinagolide Approved Phase 4 97805-50-0, 87056-78-8 105105
20
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
21
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 1 71-58-9
22 Dienogest Approved Phase 4,Phase 3,Phase 2 65928-58-7
23
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
24
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
25
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
26
Norgestrel Approved Phase 4 6533-00-2 13109
27
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
28 tannic acid Approved, Nutraceutical Phase 4,Phase 3
29
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
30
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
31
Resveratrol Experimental, Investigational Phase 4 501-36-0, 955365-80-7 24856436 445154
32
Enclomiphene Investigational Phase 4 15690-57-0
33 vitamin d Phase 4
34 Progestins Phase 4,Phase 3,Phase 2,Phase 1
35 Deslorelin Phase 4,Phase 3,Phase 2
36 Estradiol valerate Phase 4,Phase 3,Phase 2 979-32-8
37 Triptorelin Pamoate Phase 4,Phase 3
38 Analgesics Phase 4,Phase 2,Phase 3
39 diuretics Phase 4,Phase 3
40 Natriuretic Agents Phase 4,Phase 3
41 Gallopamil Phase 4
42 Neuromuscular Agents Phase 4
43 Neuromuscular Blocking Agents Phase 4
44 Neuromuscular Nondepolarizing Agents Phase 4
45 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Contraceptives, Oral Phase 4,Phase 3,Phase 2,Phase 1
47 Contraceptives, Oral, Combined Phase 4,Phase 3,Phase 2
48 Trace Elements Phase 4,Phase 3,Phase 2
49 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
50 Hormones Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 309)
id Name Status NCT ID Phase
1 Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis Unknown status NCT00654524 Phase 4
2 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Unknown status NCT02480647 Phase 4
3 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4
4 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4
5 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4
6 Supplementation in Adolescent Girls With Endometriosis Completed NCT02387931 Phase 4
7 Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence Completed NCT01769781 Phase 4
8 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed NCT01682642 Phase 4
9 Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis Completed NCT02158845 Phase 4
10 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4
11 Homeopathic Treatment of Chronic Pelvic Pain in Women With Endometriosis Completed NCT02427386 Phase 4
12 The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis Completed NCT01581359 Phase 4
13 Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain Completed NCT01056042 Phase 4
14 Resveratrol for Pain Due to Endometriosis Completed NCT02475564 Phase 4
15 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4
16 Endometriosis Patients Undergoing Quinagolide Treatment Completed NCT00625950 Phase 4
17 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4
18 Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women Completed NCT00735852 Phase 4
19 Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients Completed NCT02534688 Phase 4
20 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Recruiting NCT02165917 Phase 4
21 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest Recruiting NCT02575248 Phase 4
22 Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery Recruiting NCT02385448 Phase 4
23 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4
24 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4
25 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
26 Fluorescence Imaging + ICG Dye for Use in the Visual Diagnosis of Endometriosis Active, not recruiting NCT02038985 Phase 4
27 Ulipristal for Endometriosis-related Pelvic Pain Active, not recruiting NCT02213081 Phase 4
28 Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving Not yet recruiting NCT03080558 Phase 4
29 Psychological Impact of Amenorrhea in Women With Endometriosis Not yet recruiting NCT02393482 Phase 4
30 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4
31 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
32 Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery Unknown status NCT01125488 Phase 3
33 Laparoscopy Versus Laparotomy for Colorectal Endometriosis Unknown status NCT00939861 Phase 3
34 Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) Unknown status NCT00458458 Phase 3
35 The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study Unknown status NCT00894946 Phase 3
36 The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol Unknown status NCT01636505 Phase 3
37 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3
38 Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients Completed NCT01822080 Phase 3
39 Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis Completed NCT02271958 Phase 2, Phase 3
40 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-associated Pain Completed NCT02143713 Phase 3
41 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01620528 Phase 3
42 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01931670 Phase 3
43 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01760954 Phase 3
44 Degarelix in the Treatment of Endometriosis Recurrence Completed NCT01712763 Phase 3
45 Pentoxifylline and Endometriosis Completed NCT00632697 Phase 3
46 Medical Treatment of Endometriosis-Associated Pelvic Pain Completed NCT00229996 Phase 3
47 Safety and Efficacy of SH T00660AA in Treatment of Endometriosis Completed NCT00225186 Phase 3
48 Efficacy and Safety of SH T00660AA in Treatment of Endometriosis Completed NCT00225199 Phase 3
49 Comparative Study of BAY86-5300 With an Extended Flexible Regimen for Endometriosis Completed NCT01697111 Phase 3
50 The Effectiveness of Lng IUD for Treatment of the Patient Undergone Conservative Surgery for Pelvic Endometriosis Completed NCT00455845 Phase 3

Search NIH Clinical Center for Endometriosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: endometriosis

Genetic Tests for Endometriosis

Genetic tests related to Endometriosis:

id Genetic test Affiliating Genes
1 Endometriosis 29

Anatomical Context for Endometriosis

MalaCards organs/tissues related to Endometriosis:

39
Uterus, Ovary, Endothelial, Testes, Smooth Muscle, Monocytes, Colon

Publications for Endometriosis

Articles related to Endometriosis:

(show top 50) (show all 2542)
id Title Authors Year
1
CA 125 Relatively Specific for Diagnosing Endometriosis. ( 28084702 )
2017
2
Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis. ( 28074436 )
2017
3
Thoracic endometriosis syndrome: association with pelvic endometriosis and fertility status. ( 28069481 )
2017
4
Anisakiasis and intestinal endometriosis: under-recognized conditions in the differential diagnosis of acute abdomen. ( 28004963 )
2017
5
Does preoperative antimA1llerian hormone level influence postoperative pregnancy rate in women undergoing surgery for severe endometriosis? ( 28089574 )
2017
6
Ultrasound Imaging for Ovarian and Deep Infiltrating Endometriosis. ( 28076877 )
2017
7
Should we also work on an international informed consent for endometriosis surgery? ( 28043944 )
2017
8
Reply: Should we also work on an international informed consent for endometriosis surgery? ( 28043943 )
2017
9
Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis. ( 28042542 )
2017
10
Development of abdominal wall endometriosis in a region distant from a caesarean section scar. ( 28052369 )
2017
11
Endometriosis in the setting of Muckle-Wells syndrome treated with an IL-1I^ antagonist. ( 28508753 )
2017
12
Relating Chronic Pelvic Pain and Endometriosis to Signs of Sensitization and Myofascial Pain and Dysfunction. ( 28049214 )
2017
13
Cancer Implications for Patients with Endometriosis. ( 28049216 )
2017
14
Scar endometriosis: an entity not to be forgotten. ( 28065974 )
2017
15
Aberrant endometrial DNA methylome of homeobox A10 and catechol-O-methyltransferase in endometriosis. ( 28074437 )
2017
16
The abnormal expression of oxytocin receptors in the uterine junctional zone in women with endometriosis. ( 28049501 )
2017
17
Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis. ( 28120482 )
2017
18
Conservative approach to rectosigmoid endometriosis: a cohort study. ( 28084035 )
2017
19
Is cytochrome P450 3A4 regulated by menstrual cycle hormones in control endometrium and endometriosis? ( 27995413 )
2017
20
Surgical Management of Endometriosis in Patients with Chronic Pelvic Pain. ( 28049215 )
2017
21
Laparoscopic management of ureteral endometriosis and hydronephrosis associated with endometriosis. ( 28089810 )
2017
22
Increased IL-25 levels in the peritoneal fluid of patients with endometriosis. ( 26852387 )
2016
23
Appendiceal intussusception from endometriosis: endoscopic and laparoscopic approach. ( 27551900 )
2016
24
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study. ( 27519317 )
2016
25
High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated with Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. ( 27175969 )
2016
26
Epigenetic modifications of primordial reproductive tract: A common etiologic pathway for Mayer-Rokitansky-Kuster-Hauser Syndrome and endometriosis? ( 27063075 )
2016
27
EP27.06: Interrater agreement for the prediction of pelvic adhesions and deep infiltrating endometriosis using specialised transvaginal ultrasound: a pilot study. ( 27647803 )
2016
28
Epigenetic alterations of CYP19A1 gene in Cumulus cells and its relevance to infertility in endometriosis. ( 27167072 )
2016
29
Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells. ( 26723541 )
2016
30
EP27.07: TV-US prediction of pouch of Douglas obliteration in deep infiltrating endometriosis. ( 27647822 )
2016
31
The Serum Levels of the Soluble Factors sCD40L and CXCL1 Are Not Indicative of Endometriosis. ( 27190986 )
2016
32
Love is a pain? Quality of sex life after surgical resection of endometriosis: a review. ( 27206555 )
2016
33
Umbilical hernia masking primary umbilical endometriosis - a case report. ( 27833977 )
2016
34
Endometriosis and GlanzmannA9s thrombasthenia. ( 27655515 )
2016
35
Deep infiltrating endometriosis: Should rectal and vaginal opacification be systematically used in MR imaging? ( 27216959 )
2016
36
Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women. ( 27614631 )
2016
37
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034793 )
2016
38
Protective effect of Honokiol against endometriosis in Rats via attenuating Survivin and Bcl-2: A mechanistic study. ( 26828978 )
2016
39
IL-15 promotes growth and invasion of ESC and inhibits killing activity of NK cell in endometriosis. ( 27190213 )
2016
40
The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis. ( 27328518 )
2016
41
Disrupting Y-Box-Binding Protein 1 Function Using OSU-03012 Prevents Endometriosis Progression in In Vitro and In Vivo Models. ( 27217374 )
2016
42
Prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma: Experiences at three academic institutions. ( 27745918 )
2016
43
Pathophysiology of Endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 Developing Inflammation in Endometrium. ( 26872033 )
2016
44
Strong Association Between Endometriosis and Symptomatic Leiomyomas. ( 27647977 )
2016
45
Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis. ( 27491770 )
2016
46
Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions. ( 26604067 )
2016
47
Expression and significance of ERI^ and TrkB in endometriosis. ( 27048022 )
2016
48
Progesterone resistance in endometriosis is modulated by the altered expression of microRNA-29c and FKBP4. ( 27778641 )
2016
49
EP27.12: EndometriomaA -A the tip of a pelvic disease: TVS findings associated with an ovarian endometriosis. ( 27647664 )
2016
50
Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis. ( 27646154 )
2016

Variations for Endometriosis

Expression for Endometriosis

LifeMap Discovery
Genes differentially expressed in tissues of Endometriosis patients vs. healthy controls: 35 (show top 50) (show all 83)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PTGIS prostaglandin I2 (prostacyclin) synthase Uterus + 5.41 0.000
2 MYH11 myosin, heavy chain 11, smooth muscle Uterus + 4.87 0.001
3 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide Uterus + 4.81 0.000
4 CNN1 calponin 1, basic, smooth muscle Uterus + 4.71 0.000
5 TAGLN transgelin Uterus + 4.63 0.000
6 PAEP progestagen-associated endometrial protein Uterus + 4.63 0.013
7 PRELP proline/arginine-rich end leucine-rich repeat protein Uterus + 4.59 0.000
8 C7 complement component 7 Uterus + 4.54 0.003
9 ACTG2 actin, gamma 2, smooth muscle, enteric Uterus + 4.48 0.003
10 TCF21 transcription factor 21 Uterus + 4.45 0.000
11 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 4.42 0.001
12 WISP2 WNT1 inducible signaling pathway protein 2 Uterus + 4.11 0.001
13 AQP1 aquaporin 1 (Colton blood group) Uterus + 4.10 0.000
14 EHF ets homologous factor Uterus - 4.10 0.000
15 FOS FBJ murine osteosarcoma viral oncogene homolog Uterus + 4.09 0.000
16 FOSB FBJ murine osteosarcoma viral oncogene homolog B Uterus + 4.07 0.000
17 SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 Uterus - 4.05 0.010
18 LMNB1 lamin B1 Uterus - 4.05 0.000
19 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.99 0.000
20 DPT dermatopontin Uterus + 3.98 0.000
21 DES desmin Uterus + 3.97 0.001
22 KCNMB1 potassium channel subfamily M regulatory beta subunit 1 Uterus + 3.96 0.001
23 GATA6 GATA binding protein 6 Uterus + 3.89 0.004
24 FZD7 frizzled class receptor 7 Uterus + 3.89 0.000
25 LEFTY2 left-right determination factor 2 Uterus + 3.88 0.001
26 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.87 0.001
27 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 3.86 0.001
28 ACKR1 atypical chemokine receptor 1 (Duffy blood group) Uterus + 3.84 0.001
29 EFHC2 EF-hand domain (C-terminal) containing 2 Uterus - 3.75 0.000
30 PDLIM3 PDZ and LIM domain 3 Uterus + 3.72 0.001
31 GPC3 glypican 3 Uterus + 3.71 0.003
32 IL20RA interleukin 20 receptor, alpha Uterus - 3.70 0.000
33 MYL9 myosin, light chain 9, regulatory Uterus + 3.70 0.001
34 VNN1 vanin 1 Uterus - 3.69 0.008
35 CTSZ cathepsin Z Uterus - 3.68 0.000
36 EHF ets homologous factor Uterus - 3.67 0.000
37 LMNB1 lamin B1 Uterus - 3.61 0.000
38 CLU clusterin Uterus + 3.58 0.002
39 ACTA2 actin, alpha 2, smooth muscle, aorta Uterus + 3.57 0.000
40 TCEAL2 transcription elongation factor A (SII)-like 2 Uterus + 3.53 0.001
41 LMOD1 leiomodin 1 (smooth muscle) Uterus + 3.52 0.003
42 LMO3 LIM domain only 3 (rhombotin-like 2) Uterus + 3.51 0.002
43 TPD52 tumor protein D52 Uterus - 3.50 0.000
44 SYNPO synaptopodin Uterus + 3.48 0.001
45 KLF2 Kruppel-like factor 2 Uterus + 3.44 0.000
46 AOC3 amine oxidase, copper containing 3 Uterus + 3.44 0.003
47 KCNK3 potassium channel, two pore domain subfamily K, member 3 Uterus + 3.44 0.007
48 ZBBX zinc finger, B-box domain containing Uterus - 3.43 0.001
49 FMO1 flavin containing monooxygenase 1 Uterus + 3.43 0.000
50 ZBBX zinc finger, B-box domain containing Uterus - 3.42 0.002
Search GEO for disease gene expression data for Endometriosis.

Pathways for Endometriosis

Pathways related to Endometriosis according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 ESR1 ESR2 GNRH1 IL1B VEGFA
2
Show member pathways
12.24 CCL2 CXCL8 IL1B IL6
3 12.15 CXCL8 HOXA10 IL1R2 IL6
4 12.04 CXCL8 ESR2 IL1B IL6 VEGFA
5 11.99 CCL2 IL1B IL1R2 VEGFA
6 11.9 CCL2 CXCL8 IL1B IL6
7 11.82 CCL2 CXCL8 IL1B IL6 VEGFA
8 11.79 CXCL8 IL1B IL1R2 IL6
9
Show member pathways
11.75 ESR1 ESR2 NR5A1 PGR
10 11.73 CXCL8 IL1B IL6
11 11.72 CCL2 CXCL8 IL1B IL6 VEGFA
12 11.67 CXCL8 IL1B IL6
13 11.58 CCL2 CXCL8 IL1B IL6
14
Show member pathways
11.56 CXCL8 IL1B IL6 VEGFA
15 11.51 CXCL8 IL1B IL6
16 11.51 CCL2 CXCL8 IL1B IL6 VEGFA
17 11.47 CXCL8 IL6 VEGFA
18 11.43 AHRR ESR1 VEGFA
19 11.4 CCL2 CXCL8 IL1B IL6
20 11.39 CYP19A1 IL1B IL6
21 11.24 CCL2 CXCL8 IL6
22 11.14 CCL2 CXCL8 IL1B IL6
23 11.06 CYP19A1 ESR2 NR5A1 PGR
24 11.04 CCL2 CXCL8 IL1B IL1R2 IL6
25 10.27 CYP19A1 HSD17B1
26 9.53 CYP19A1 ESR1 ESR2 HSD17B1

GO Terms for Endometriosis

Cellular components related to Endometriosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 CCL2 CXCL8 ESR2 GNRH1 IL1B IL1R2

Biological processes related to Endometriosis according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CCL2 CXCL8 IL1B IL1R2 IL6
2 response to lipopolysaccharide GO:0032496 9.81 CCL2 GNRH1 IL1B IL6
3 cell-cell signaling GO:0007267 9.77 ESR2 GNRH1 IL1B NR5A1 PGR
4 cytokine-mediated signaling pathway GO:0019221 9.76 CCL2 IL1B IL1R2 IL6
5 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.76 AHRR ESR1 HOXA10 IL1B IL6 NR5A1
6 transcription initiation from RNA polymerase II promoter GO:0006367 9.73 ESR1 ESR2 NR5A1 PGR
7 cellular response to interleukin-1 GO:0071347 9.72 CCL2 CXCL8 IL6
8 neutrophil chemotaxis GO:0030593 9.7 CCL2 CXCL8 IL1B
9 PERK-mediated unfolded protein response GO:0036499 9.57 CCL2 CXCL8
10 estrogen biosynthetic process GO:0006703 9.56 CYP19A1 HSD17B1
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.56 ESR1 ESR2 IL1B IL6
12 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.54 IL1B PAEP
13 cellular response to estradiol stimulus GO:0071392 9.5 CCL2 ESR1 IL6
14 testosterone biosynthetic process GO:0061370 9.49 CYP19A1 HSD17B1
15 regulation of vascular endothelial growth factor production GO:0010574 9.48 CCL2 IL6
16 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.4 IL1R2 IL6
17 uterus development GO:0060065 9.13 CYP19A1 ESR1 HOXA10
18 steroid hormone mediated signaling pathway GO:0043401 8.92 ESR1 ESR2 NR5A1 PGR

Molecular functions related to Endometriosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 CCL2 CXCL8 IL1B IL6 VEGFA
2 steroid hormone receptor activity GO:0003707 9.46 ESR1 ESR2 NR5A1 PGR
3 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
4 estrogen response element binding GO:0034056 9.37 ESR1 ESR2
5 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.32 ESR1 ESR2
6 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.26 ESR1 ESR2 NR5A1 PGR
7 steroid binding GO:0005496 8.92 ESR1 ESR2 HSD17B1 PGR

Sources for Endometriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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