MCID: END011
MIFTS: 41

Endometriosis of Ovary

Categories: Reproductive diseases

Aliases & Classifications for Endometriosis of Ovary

MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 14 69
Ovarian Endometriosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11432
ICD10 32 N80.1
ICD9CM 34 617.1
NCIt 46 C27628
UMLS 69 C0156344

Summaries for Endometriosis of Ovary

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and vaginitis. An important gene associated with Endometriosis of Ovary is LINC00339 (Long Intergenic Non-Protein Coding RNA 339), and among its related pathways/superpathways are Gastric cancer and Nuclear Receptor transcription pathway. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are endocrine/exocrine gland and muscle

Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 endometriosis 30.9 CYP19A1 ESR1 ESR2 HNF1B PGR
2 vaginitis 30.2 ESR1 ESR2
3 adenomyosis 30.2 ESR1 PGR
4 ovarian serous cystadenocarcinoma 30.0 ESR2 PGR
5 infertility 30.0 CYP19A1 ESR2 PGR
6 endometrial adenocarcinoma 30.0 ESR1 ESR2 PGR
7 endometrial stromal sarcoma 29.8 CYP19A1 ESR1 PGR
8 leiomyoma 29.8 CYP19A1 ESR1 ESR2 PGR
9 ovarian cancer 1 29.6 ARID1A ESR1 HNF1B PGR
10 leiomyoma, uterine 29.5 CYP19A1 ESR1 ESR2 PGR
11 postmenopausal atrophic vaginitis 10.5 ESR1 ESR2
12 dental fluorosis 10.5 ESR1 ESR2
13 vulvar syringoma 10.5 ESR1 PGR
14 vestibular gland benign neoplasm 10.5 ESR1 PGR
15 lung leiomyoma 10.5 ESR1 PGR
16 bartholin's gland adenoma 10.5 ESR1 PGR
17 glassy cell carcinoma of the cervix 10.5 ESR1 PGR
18 vulvar benign neoplasm 10.5 ESR1 PGR
19 trigonitis 10.5 ESR1 PGR
20 vulvar leiomyoma 10.5 ESR1 PGR
21 predominantly cortical thymoma 10.5 ESR1 PGR
22 breast medullary carcinoma 10.5 ESR1 PGR
23 breast scirrhous carcinoma 10.5 ESR1 PGR
24 cribriform carcinoma 10.5 ESR1 PGR
25 oncocytic breast carcinoma 10.5 ESR1 PGR
26 bartholin's gland benign neoplasm 10.4 ESR1 PGR
27 endometrial squamous cell carcinoma 10.4 ESR1 PGR
28 lobular neoplasia 10.4 ESR1 ESR2
29 gastric signet ring cell adenocarcinoma 10.4 ESR1 PGR
30 endometrial mucinous adenocarcinoma 10.4 ESR1 PGR
31 adenoid basal cell carcinoma 10.4 ESR1 PGR
32 deep angioma 10.4 ESR1 PGR
33 apocrine adenocarcinoma 10.4 ESR1 PGR
34 cervical carcinosarcoma 10.4 ESR1 PGR
35 synchronous bilateral breast carcinoma 10.4 ESR1 PGR
36 breast adenoid cystic carcinoma 10.4 ESR1 PGR
37 intramuscular hemangioma 10.4 ESR1 PGR
38 glycogen-rich clear cell breast carcinoma 10.4 ESR1 PGR
39 retinitis pigmentosa 47 10.4 ESR1 PGR
40 retinitis pigmentosa 20 10.4 ESR1 PGR
41 luminal breast carcinoma 10.4 ESR1 PGR
42 transsexualism 10.4 CYP19A1 ESR2
43 breast benign neoplasm 10.4 ESR1 PGR
44 thoracic benign neoplasm 10.4 ESR1 PGR
45 adenosarcoma 10.4 ESR1 PGR
46 cervical clear cell adenocarcinoma 10.4 ESR1 PGR
47 uterine corpus cancer 10.4 ESR1 PGR
48 inflammatory breast carcinoma 10.4 ESR1 PGR
49 mixed cell type cancer 10.4 ESR1 PGR
50 lipid-rich carcinoma 10.4 ESR1 PGR

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Fallopian Tube Endometriosis
Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary

Symptoms & Phenotypes for Endometriosis of Ovary

MGI Mouse Phenotypes related to Endometriosis of Ovary:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 AMH ARID1A CYP19A1 ESR1 ESR2 HNF1B
2 muscle MP:0005369 9.63 ARID1A CYP19A1 ESR1 ESR2 HNF1B PGR
3 neoplasm MP:0002006 9.35 AMH ARID1A ESR1 ESR2 PGR
4 reproductive system MP:0005389 9.17 AKR1C3 AMH ARID1A CYP19A1 ESR1 ESR2

Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 5311128 47725
3 Antineoplastic Agents, Hormonal Phase 4,Phase 2
4 Aromatase Inhibitors Phase 4
5 Estrogen Antagonists Phase 4
6 Estrogens Phase 4
7 Hormone Antagonists Phase 4
8 Hormones Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Steroid Synthesis Inhibitors Phase 4
11
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
12 Contraceptive Agents Phase 2
13 Contraceptive Agents, Male Phase 2
14
Medroxyprogesterone Phase 2 520-85-4 10631
15
Edetic Acid Approved, Vet_approved 60-00-4, 62-33-9 6049
16 Anesthetics
17 Pentetic Acid

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 PGL5001 Proof of Concept Study in Inflammatory Endometriosis Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
4 Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients Completed NCT02984774
5 Perinatal Consequences of Endometriosis Recruiting NCT02498691
6 Artificial Reproductive Techniques (ART) and Progression of Endometriosis Symptoms Recruiting NCT02762461
7 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma Not yet recruiting NCT03430609

Search NIH Clinical Center for Endometriosis of Ovary

Genetic Tests for Endometriosis of Ovary

Anatomical Context for Endometriosis of Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

38
Ovary

Publications for Endometriosis of Ovary

Articles related to Endometriosis of Ovary:

(show top 50) (show all 183)
# Title Authors Year
1
Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma. ( 28930811 )
2017
2
Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization. ( 28931865 )
2017
3
Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis. ( 28974971 )
2016
4
Persistent Mullerian Duct Syndrome with Ovarian Endometriosis-A Rare Case Report. ( 27042476 )
2016
5
Increased Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Patients With Ovarian Endometriosis. ( 26342048 )
2016
6
EP27.12: EndometriomaA -A the tip of a pelvic disease: TVS findings associated with an ovarian endometriosis. ( 27647664 )
2016
7
Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis. ( 27646154 )
2016
8
The co-expression of GPER and Gankyrin in ovarian endometriosis and its correlation with the rASRM stages. ( 26193952 )
2016
9
Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53 and heme oxygenase-1. ( 25772769 )
2015
10
MiR-191 inhibits TNF-I+ induced apoptosis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1. ( 26191186 )
2015
11
Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2I+ biosynthesis and action in ovarian endometriosis tissue and in model cell lines. ( 25446850 )
2015
12
Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis. ( 24884521 )
2014
13
Tubal origin of ovarian endometriosis. ( 24390223 )
2014
14
Surgically treated ovarian endometriosis association with BRCA1 and BRCA2 mutations. ( 24472143 )
2014
15
Phospholipase A2 group IIA is elevated in endometriomas but not in peritoneal fluid and serum of ovarian endometriosis patients. ( 25366587 )
2014
16
RUNX3 is inactivated by promoter hypermethylation in malignant transformation of ovarian endometriosis. ( 25333219 )
2014
17
Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis. ( 25150394 )
2014
18
Genome-wide profiling of long noncoding ribonucleic acid expression patterns in ovarian endometriosis by microarray. ( 24502888 )
2014
19
High-resolution array-comparative genomic hybridization profiling reveals 20q13.33 alterations associated with ovarian endometriosis. ( 23656391 )
2013
20
Long term survival of ovarian endometriosis associated clear cell and endometrioid ovarian cancers. ( 23314280 )
2013
21
MicroRNAs expression profiling of eutopic proliferative endometrium in women with ovarian endometriosis. ( 23945042 )
2013
22
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS? ( 23277161 )
2013
23
Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis. ( 23461865 )
2013
24
MicroRNA23a and microRNA23b deregulation derepresses SF-1 and upregulates estrogen signaling in ovarian endometriosis. ( 23450049 )
2013
25
Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis. ( 22626277 )
2012
26
Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis. ( 22859507 )
2012
27
Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. ( 22401780 )
2012
28
The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. ( 22633261 )
2012
29
Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis. ( 23113924 )
2012
30
Epigenetic inactivation of hMLH1 in the malignant transformation of ovarian endometriosis. ( 21556900 )
2012
31
Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma. ( 22977660 )
2012
32
Fertility preservation in women with ovarian endometriosis. ( 22201982 )
2012
33
The G-protein-coupled estrogen receptor (GPER) is expressed in normal human ovaries and is upregulated in ovarian endometriosis and pelvic inflammatory disease involving the ovary. ( 22573494 )
2012
34
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. ( 22611972 )
2012
35
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis. ( 21944080 )
2012
36
Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis. ( 21130491 )
2011
37
Primary squamous cell carcinoma associated with ovarian endometriosis: a case report and literature review. ( 21301917 )
2011
38
Frequency of ovarian endometriosis in epithelial ovarian cancer patients. ( 22268283 )
2011
39
Follicular loss in endoscopic surgery for ovarian endometriosis: quantitative and qualitative observations. ( 21703608 )
2011
40
Identification of cells with colony-forming activity, self-renewal capacity, and multipotency in ovarian endometriosis. ( 21641404 )
2011
41
Involvement of estrogen receptor-related receptors in human ovarian endometriosis. ( 21561608 )
2011
42
Two-dimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis. ( 21497343 )
2011
43
Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis. ( 21397694 )
2011
44
Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis. ( 21232532 )
2011
45
Expression patterns of the steroid receptor coactivator family in human ovarian endometriosis. ( 21518137 )
2011
46
Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. ( 20300586 )
2010
47
Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis. ( 19955103 )
2010
48
Steroidogenic factor-1 expression in ovarian endometriosis. ( 19875956 )
2010
49
Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium. ( 20155281 )
2010
50
A retrospective analysis of ovarian endometriosis during pregnancy. ( 19356751 )
2010

Variations for Endometriosis of Ovary

Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

Pathways for Endometriosis of Ovary

GO Terms for Endometriosis of Ovary

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.72 ARID1A ESR1 ESR2 HNF1B TRERF1
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.63 ESR1 ESR2 PGR
3 mammary gland development GO:0030879 9.49 CYP19A1 PGR
4 regulation of Wnt signaling pathway GO:0030111 9.48 ESR1 HNF1B
5 androgen metabolic process GO:0008209 9.43 CYP19A1 ESR1
6 uterus development GO:0060065 9.4 CYP19A1 ESR1
7 estrogen biosynthetic process GO:0006703 9.37 CYP19A1 HSD17B2
8 steroid biosynthetic process GO:0006694 9.33 CYP19A1 HSD17B2 TRERF1
9 testosterone biosynthetic process GO:0061370 9.26 AKR1C3 CYP19A1
10 steroid hormone mediated signaling pathway GO:0043401 9.13 ESR1 ESR2 PGR
11 intracellular estrogen receptor signaling pathway GO:0030520 8.8 ARID1A ESR1 ESR2

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.83 ESR1 ESR2 HNF1B PGR TRERF1
2 steroid hormone receptor activity GO:0003707 9.54 ESR1 ESR2 PGR
3 testosterone dehydrogenase (NAD+) activity GO:0047035 9.4 AKR1C3 HSD17B2
4 nuclear receptor activity GO:0004879 9.33 ESR1 ESR2 PGR
5 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
6 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
7 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
8 steroid binding GO:0005496 8.8 ESR1 ESR2 PGR

Sources for Endometriosis of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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