MCID: END011
MIFTS: 33

Endometriosis of Ovary malady

Categories: Reproductive diseases

Aliases & Classifications for Endometriosis of Ovary

Aliases & Descriptions for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 14 69
Ovarian Endometriosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11432
ICD10 33 N80.1
ICD9CM 35 617.1
NCIt 47 C27628
UMLS 69 C0156344

Summaries for Endometriosis of Ovary

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and ulceroglandular tularemia. An important gene associated with Endometriosis of Ovary is HNF1B (HNF1 Homeobox B), and among its related pathways/superpathways are Nuclear Receptor transcription pathway and Steroid hormone biosynthesis. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are endocrine/exocrine gland and muscle

Wikipedia : 71 An endometrioma, endometrioid cyst, endometrial cyst, or chocolate cyst of ovary is a condition related... more...

Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 endometriosis 10.8
2 ulceroglandular tularemia 10.3 ESR1 ESR2
3 bartholin's gland benign neoplasm 10.3 ESR1 PGR
4 cardiovascular organ benign neoplasm 10.3 ESR1 PGR
5 appendix leiomyoma 10.3 ESR1 PGR
6 bronchus adenoma 10.3 ESR1 PGR
7 glioma 10.3 ESR1 PGR
8 ovarian benign neoplasm 10.3 ESR1 PGR
9 plexiform neurofibroma 10.3 ESR1 PGR
10 paranasal sinus disease 10.3 ESR1 PGR
11 cervical lymphoepithelioma-like carcinoma 10.3 ESR1 PGR
12 borderline personality disorder 10.3 CYP19A1 ESR2
13 histiocytic and dendritic cell cancer 10.3 ESR1 PGR
14 atypical lipomatous tumor 10.3 ESR1 PGR
15 pediatric intraocular retinoblastoma 10.3 ESR1 PGR
16 congenital disorder of glycosylation, type ic 10.3 ESR1 PGR
17 intestinal perforation 10.3 ESR1 PGR
18 perlman syndrome 10.3 ESR1 PGR
19 nervous system hibernoma 10.3 ESR1 PGR
20 neuroschistosomiasis 10.3 ESR1 ESR2
21 bladder adenocarcinoma 10.3 ESR1 PGR
22 anal neuroendocrine tumor 10.2 ESR1 PGR
23 poliomyelitis 10.2 ESR1 PGR
24 vulva basal cell carcinoma 10.2 ESR1 PGR
25 villoglandular endometrial endometrioid adenocarcinoma 10.2 ESR1 PGR
26 substance abuse 10.2 ESR1 ESR2
27 vaginal adenosarcoma 10.2 ESR1 PGR
28 biemond syndrome 10.2 CYP19A1 PGR
29 intraneural perineurioma 10.2 ESR1 PGR
30 middle ear adenocarcinoma 10.2 ESR1 PGR
31 paraphimosis 10.2 ESR1 PGR
32 central nervous system mature teratoma 10.2 ESR1 PGR
33 panophthalmitis 10.2 CYP19A1 PGR
34 celiac disease 12 10.2 CYP19A1 ESR1
35 rectal neoplasm 10.2 ESR1 PGR
36 postpartum depression 10.2 ESR1 PGR
37 mucoepidermoid esophageal carcinoma 10.2 ESR1 PGR
38 peritonitis 10.2
39 blepharochalasis 10.2 CYP19A1 ESR1 HNF1B
40 combined t cell and b cell immunodeficiency 10.2 ESR1 PGR
41 carbuncle 10.2 ESR1 ESR2
42 anomalous left coronary artery from the pulmonary artery 10.2 ESR1 PGR
43 peeling skin syndrome 10.2 ESR1 ESR2 PGR
44 pituitary stalk meningioma 10.2 ESR1 ESR2 PGR
45 adult neuronal ceroid lipofuscinosis 10.2 ESR1 PGR
46 adams-oliver syndrome 6 10.2 CYP19A1 ESR1
47 prostatic adenoma 10.2 ESR1 ESR2 PGR
48 necrobiosis lipoidica 10.2 ESR1 ESR2 PGR
49 bardet-biedl syndrome 10.2 ESR1 ESR2 PGR
50 esophagus sarcoma 10.2 CYP19A1 ESR1 PGR

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Fallopian Tube Endometriosis
Uterine Fibroid

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary

Symptoms & Phenotypes for Endometriosis of Ovary

MGI Mouse Phenotypes related to Endometriosis of Ovary:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 AMH ARID1A CYP19A1 ESR1 ESR2 HNF1B
2 muscle MP:0005369 9.63 ARID1A CYP19A1 ESR1 ESR2 HNF1B PGR
3 neoplasm MP:0002006 9.35 AMH ARID1A ESR1 ESR2 PGR
4 reproductive system MP:0005389 9.17 ESR2 PGR AKR1C3 AMH ARID1A CYP19A1

Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 47725 5311128
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
4
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
5
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
6
Norgestrel Approved Phase 4 6533-00-2 13109
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
8
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
9 Antineoplastic Agents, Hormonal Phase 4,Phase 2
10 Aromatase Inhibitors Phase 4
11 Estrogen Antagonists Phase 4
12 Estrogens Phase 4,Phase 1
13 Hormone Antagonists Phase 4,Phase 1
14 Hormones Phase 4,Phase 1
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1
16 Steroid Synthesis Inhibitors Phase 4
17 Contraceptive Agents Phase 4,Phase 2
18 Estradiol 17 beta-cypionate Phase 4
19 Estradiol 3-benzoate Phase 4
20 Estradiol valerate Phase 4 979-32-8
21 Polyestradiol phosphate Phase 4
22 Contraceptives, Oral Phase 4
23 Contraceptives, Oral, Combined Phase 4
24 Contraceptives, Postcoital Phase 4
25 Ethinyl estradiol, levonorgestrel drug combination Phase 4
26 Ethinyl Estradiol-Norgestrel Combination Phase 4
27 BB 1101 Phase 4
28 Dexamethasone 21-phosphate Phase 4
29 Dexamethasone acetate Phase 4 1177-87-3
30
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
31 Contraceptive Agents, Male Phase 2
32
Medroxyprogesterone Phase 2 520-85-4 10631
33
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754 657311
34
Progesterone Approved, Vet_approved Phase 1 57-83-0 5994
35 Cortisol succinate Phase 1
36 Hydrocortisone 17-butyrate 21-propionate Phase 1
37 Hydrocortisone acetate Phase 1
38 Progestins Phase 1
39
Edetic Acid Approved, Vet_approved 60-00-4, 62-33-9 6049
40
Letrozole Approved, Investigational 112809-51-5 3902
41
Enclomiphene Investigational 15690-57-0
42 insulin
43 Insulin, Globin Zinc
44 Anesthetics
45 Pentetic Acid
46 Pharmaceutical Solutions
47 Anticoagulants
48 Calcium, Dietary
49 Chelating Agents
50 Clomiphene

Interventional clinical trials:

(show all 30)
id Name Status NCT ID Phase
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4
2 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4
3 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
4 Evaluation of Adhexil Safety and Efficacy in Prevention and/or Reduction of Adhesions in Gynecological Surgery Suspended NCT00865488 Phase 3
5 Ovarian Endometrioma Ablation Using Plasma Energy Versus Cystectomy Unknown status NCT01596985 Phase 2
6 PGL5001 Proof of Concept Study in Inflammatory Endometriosis Completed NCT01630252 Phase 2
7 Surgicel Reduces Ovarian Endometriomas Recurrence Recruiting NCT02947724 Phase 2
8 Comparison of Blood Levels of Two Formulations of the Selective Hormone Receptor Modulator CDB-2914 Completed NCT00041899 Phase 1
9 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
10 Post-operative Ovarian Adhesion Study in Women With Endometriosis Unknown status NCT01989260
11 Tissue Samples and Bodily Fluid Specimens Banking Unknown status NCT02431884
12 The Impact of Surgical Treatment of Endometriomas on Ovarian Reserve Unknown status NCT01425333
13 Prevalence of HbA1C in Women With PCOS Unknown status NCT01838122
14 Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients Completed NCT02984774
15 Case Report of Endometrioma in Layers of Broad Ligament. Completed NCT02513953
16 Mathematical Model for the Human Menstrual Cycle, Endocrinological Diseases and Fertility Treatment-PAEON Completed NCT02098668
17 Pelvic Pain in Women With Endometriosis Completed NCT00073801
18 Edessy Stem Cell Score (ESS), Endometrium, Endometrioma Completed NCT02103452
19 The Influence of Polycystic Ovairan Syndrome on Embryonic Developmental Timing Completed NCT01953146
20 Laparoscopic Ovarian Cystectomy of Endometrioma vs Deroofing and Ovarian Reserve Completed NCT01808170
21 Perinatal Consequences of Endometriosis Recruiting NCT02498691
22 Artificial Reproductive Techniques (ART) and Progression of Endometriosis Symptoms Recruiting NCT02762461
23 ENDmetriosis and Reserve Ovarienne Recruiting NCT02400684
24 MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome Recruiting NCT03142633
25 Effect of Shorten Gonadotropin-releasing Hormone Agonist Therapy on the Outcome of in Vitro Fertilization-Embryo Transfer in Patients With Endometriosis Recruiting NCT03006406
26 A Comparison of Letrozole and Clomifene Citrate Recruiting NCT02647424
27 Effect of Salpingectomy During Conservative Hysterectomy Recruiting NCT01628432
28 A New Algorithm to Predict Ovarian Age Recruiting NCT02086318
29 Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells Recruiting NCT02877992
30 Three Different Laparoscopic Approaches for Ovarian Endometrioma and the Effect on Ovarian Reserve Active, not recruiting NCT02754648

Search NIH Clinical Center for Endometriosis of Ovary

Genetic Tests for Endometriosis of Ovary

Anatomical Context for Endometriosis of Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

39
Ovary

Publications for Endometriosis of Ovary

Variations for Endometriosis of Ovary

Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

Pathways for Endometriosis of Ovary

GO Terms for Endometriosis of Ovary

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.73 ARID1A ESR1 ESR2 HNF1B
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.58 ESR1 ESR2 PGR
3 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
4 uterus development GO:0060065 9.32 CYP19A1 ESR1
5 estrogen biosynthetic process GO:0006703 9.26 CYP19A1 HSD17B2
6 testosterone biosynthetic process GO:0061370 9.16 AKR1C3 CYP19A1
7 steroid hormone mediated signaling pathway GO:0043401 9.13 ESR1 ESR2 PGR
8 intracellular estrogen receptor signaling pathway GO:0030520 8.8 ARID1A ESR1 ESR2

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.73 ESR1 ESR2 HNF1B PGR
2 steroid hormone receptor activity GO:0003707 9.5 ESR1 ESR2 PGR
3 testosterone dehydrogenase (NAD+) activity GO:0047035 9.4 AKR1C3 HSD17B2
4 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
5 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.33 ESR1 ESR2 PGR
6 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
7 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
8 steroid binding GO:0005496 8.8 ESR1 ESR2 PGR

Sources for Endometriosis of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....