Endometriosis of Uterus

Categories: Reproductive diseases

Aliases & Classifications for Endometriosis of Uterus

MalaCards integrated aliases for Endometriosis of Uterus:

Name: Endometriosis of Uterus 12 14 69
Endometriosis of Myometrium 12
Endometriosis, Myometrium 12
Endometriosis Interna 12
Uterine Adenomyosis 12
Adenomyosis 42


External Ids:

Disease Ontology 12 DOID:288
ICD10 33 N80.0
ICD9CM 35 617.0
MeSH 42 D062788
NCIt 47 C6996
UMLS 69 C0341858

Summaries for Endometriosis of Uterus

MalaCards based summary : Endometriosis of Uterus, also known as endometriosis of myometrium, is related to adenomyosis and vestibular gland benign neoplasm. An important gene associated with Endometriosis of Uterus is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Signaling by ERBB4 and Signaling events mediated by PTP1B. The drugs Levonorgestrel and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include uterus, bone and testes, and related phenotype is integument.

Related Diseases for Endometriosis of Uterus

Diseases related to Endometriosis of Uterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
id Related Disease Score Top Affiliating Genes
1 adenomyosis 11.1
2 vestibular gland benign neoplasm 10.3 HPSE2 PRL
3 african histoplasmosis 10.2 GNRH1 PRL
4 adenomatoid tumor 10.2 GNRH1 PRL
5 intermittent squint 10.2 GNRH1 PRL
6 lymphoepithelioma-like carcinoma 10.2 GNRH1 PRL
7 vertebral artery occlusion 10.1 GNRH1 PRL
8 lactic acidosis 10.1 GNRH1 PRL
9 internal hemorrhoid 10.1 GNRH1 PRL
10 retinitis pigmentosa 46 10.1 GNRH1 PRL
11 sphingolipidosis 10.1 GNRH1 PRL
12 uterine corpus adenocarcinofibroma 10.1 GNRH1 PRL
13 acute myocarditis 10.1 GNRH1 PRL
14 porokeratosis 10.1 GNRH1 PRL
15 retroperitoneal sarcoma 10.1 GNRH1 PRL
16 uterine ligament clear cell adenocarcinoma 10.1 GNRH1 PRL
17 spondylolysis 10.0 GNRH1 PRL
18 adamantinous craniopharyngioma 10.0 GNRH1 PRL
19 nephrogenic adenofibroma 10.0 GNRH1 HPSE2
20 pelvic muscle wasting 10.0 GNRH1 PRL
21 haverhill fever 10.0 GNRH1 PRL
22 rare endometriosis 10.0
23 acute gonococcal salpingitis 10.0 GNRH1 PRL
24 avoidant personality disorder 9.9 GNRH1 PRL
25 allergic asthma 9.9 GNRH1 PRL
26 adrenoleukodystrophy 9.8 GNRH1 PRL
27 precursor b lymphoblastic lymphoma/leukemia 9.8 GNRH1 PRL
28 pseudopterygium 9.7 GNRH1 PRL
29 plague 9.6 PRL PRLR
30 thrombophilia 9.5 GNRH1 PRL
31 diencephalic neoplasm 9.3 GNRH1 PRL PRLR
32 alpha-methylacyl-coa racemase deficiency 9.3 GNRH1 PRL PRLR
33 aortic valve prolapse 9.3 GNRH1 PRL PRLR
34 prostate leiomyoma 7.9 DHX9 GNRH1 HPSE2 NCF1 PRL PRLR

Comorbidity relations with Endometriosis of Uterus via Phenotypic Disease Network (PDN):

Asherman's Syndrome Cervix Uteri Carcinoma in Situ
Chronic Salpingo-Oophoritis Endometriosis of Ovary
Fallopian Tube Endometriosis Female Stress Incontinence
Submucous Uterine Fibroid Subserous Uterine Fibroid
Uterine Fibroid

Graphical network of the top 20 diseases related to Endometriosis of Uterus:

Diseases related to Endometriosis of Uterus

Symptoms & Phenotypes for Endometriosis of Uterus

MGI Mouse Phenotypes related to Endometriosis of Uterus:

id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 GNRH1 NCF1 PRL PRLR

Drugs & Therapeutics for Endometriosis of Uterus

Drugs for Endometriosis of Uterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Levonorgestrel Approved, Investigational Phase 4,Phase 2,Early Phase 1 797-63-7, 17489-40-6 13109
Acetaminophen Approved Phase 4 103-90-2 1983
Ibuprofen Approved Phase 4 15687-27-1 3672
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Desogestrel Approved Phase 4 54024-22-5 40973
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-28-2 5757
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3,Early Phase 1 57-63-6 5991
Norgestrel Approved Phase 4 6533-00-2 13109
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
11 Contraceptive Agents Phase 4,Phase 2,Phase 3,Early Phase 1
12 Contraceptives, Oral Phase 4,Phase 2,Early Phase 1
13 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
14 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Progestins Phase 4,Phase 2,Phase 3,Early Phase 1
17 Contraceptives, Oral, Combined Phase 4,Phase 2,Early Phase 1
18 Analgesics Phase 4,Phase 3
19 Analgesics, Non-Narcotic Phase 4
20 Anti-Inflammatory Agents Phase 4
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4
22 Antipyretics Phase 4
23 Antirheumatic Agents Phase 4
24 Cyclooxygenase Inhibitors Phase 4
25 Estradiol 17 beta-cypionate Phase 4,Phase 2,Phase 3,Early Phase 1
26 Estradiol 3-benzoate Phase 4,Phase 2,Phase 3,Early Phase 1
27 Estradiol valerate Phase 4,Phase 2,Phase 3,Early Phase 1 979-32-8
28 Polyestradiol phosphate Phase 4,Phase 2,Phase 3,Early Phase 1
29 Contraceptives, Postcoital Phase 4
30 Ethinyl estradiol, levonorgestrel drug combination Phase 4
31 Ethinyl Estradiol-Norgestrel Combination Phase 4
32 Ramosetron Approved Phase 3 132036-88-5
Ethiodized oil Approved Phase 3 8008-53-5
Goserelin Approved Phase 2, Phase 3 65807-02-5 47725 5311128
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
Lactitol Investigational Phase 2, Phase 3 585-86-4 3871
37 Antiemetics Phase 3
38 Autonomic Agents Phase 3
39 Gastrointestinal Agents Phase 3
40 Neurotransmitter Agents Phase 3,Phase 1
Serotonin Phase 3 50-67-9 5202
42 Serotonin Agents Phase 3
43 Serotonin Antagonists Phase 3
44 Antineoplastic Agents, Hormonal Phase 2, Phase 3
45 Aromatase Inhibitors Phase 2, Phase 3
46 Estrogen Antagonists Phase 2, Phase 3
47 Estrogens Phase 2, Phase 3,Early Phase 1
48 Steroid Synthesis Inhibitors Phase 2, Phase 3
49 Micronutrients Phase 3
50 Trace Elements Phase 3

Interventional clinical trials:

(show top 50) (show all 81)

id Name Status NCT ID Phase Drugs
1 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;IV Placebo
2 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Completed NCT02480647 Phase 4 Levonorgestrel;Etonogestrel
3 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4 Combined Oral Contraceptive Pill (Microgynon 30)
4 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
5 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
6 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
7 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3 Ramosetron
8 The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study Unknown status NCT00894946 Phase 3
9 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
10 Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy Completed NCT01064128 Phase 3
11 Uterine Artery Embolization for Symptomatic Fibroids Completed NCT00354471 Phase 3
12 Efficacy of Trace Elements in the Treatment of Endometriosis: a Pilot Study Active, not recruiting NCT02437175 Phase 3
13 Evaluation of a Subcutaneous Progestogen Implants in the Medical Management of Painful Endometriosis Not yet recruiting NCT02669238 Phase 2, Phase 3 Minidril®/Leeloo®
14 LNG-IUS for Treatment of Dysmenorrhea Unknown status NCT01601366 Phase 2 Combined oral contraceptives
15 Tactile Electrosurgical Ablation in Cases of Dysfunctional Uterine Bleeding Completed NCT02248194 Phase 2
16 The Safety and Effectiveness of Surgery With or Without Raloxifene for the Treatment of Pelvic Pain Caused by Endometriosis Completed NCT00001848 Phase 2 Raloxifene
17 Letrozole in the Treatment of Severe and Recurrent Endometriosis Completed NCT00240942 Phase 2 Letrozole
18 Adenomyosis and Ulipristal Acetate Recruiting NCT02587000 Phase 2 Ulipristal acetate;Placebo
19 Superior Hypogastric Nerve Block for Pain Control Post-UFE Recruiting NCT02270255 Phase 2 0.75% Ropivacaine;1% Xylocaine
20 Placebo-controlled Proof of Concept Study of Epelsiban in Women With Adenomyosis Withdrawn NCT02794467 Phase 2 Epelsiban;Placebo
21 Vaginal Bromocriptine for Treatment of Adenomyosis Active, not recruiting NCT01821001 Phase 1 Vaginal Bromocriptine
22 Efficacy of Acupuncture on Chronic Pelvic Pain in Women With Endometriosis or Adenomyosis Unknown status NCT01259180
23 Evaluation of Endometrial Stromal Cell Apoptosis in Adenomyosis Unknown status NCT00172588
24 Proliferation of Endometrial Stromal Cells in Adenomyosis Unknown status NCT00173212
25 Health-Related QoL Among Women Receiving Hysterectomy in NTUH Unknown status NCT00155870
26 Progestin Treatment for Endometrial Stromal Cells in Adenomyosis Unknown status NCT00155051
27 To Compare to 2-channel and Multiple-channel Single Port Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01564602
28 The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH) Unknown status NCT00928044
29 Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy Unknown status NCT01289314
30 Post-operative Ovarian Adhesion Study in Women With Endometriosis Unknown status NCT01989260
31 ENDOMET - Novel Diagnostic Tools and Treatments for Endometriosis Unknown status NCT01301885
32 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
33 Histopathological Diagnosis of Adenomyosis Completed NCT02340533
34 Norwegian Adenomyosis Study I Completed NCT02201719
35 Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis Completed NCT03027648
36 Levonorgestrel Intrauterine System and Adenomyosis Completed NCT03104309
37 New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma Completed NCT02997787
38 Use of Dexamethasone in Uterine Artery Embolization Completed NCT02056717 Dexamethasone;Normal saline
39 AMH Levels Change During Treatment With GnRh Agonist Completed NCT02086279 GnRH analogue
40 Does 3D Laparoscopy Improve Vaginal Cuff Suture Time? Completed NCT02192606
41 Use of the Enseal Intrument for Laparoscopic Supracervical Hysterectomy Completed NCT01806012
42 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Completed NCT01793584
43 Electronic Catheter Stethoscope Completed NCT01463462
44 Sonohysterography , 3D Ultrasonography and Hysteroscopy in Assessment of Uterine Factor in Cases of Female Infertility Completed NCT02399501
45 Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning Completed NCT01468935
46 Observational Study Rheumatological Manifestations Associated With Endometriosis Completed NCT02826980
47 Effects of Endometriosis on Bone Mineral Density Completed NCT00291278
48 Short Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01287611
49 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure Completed NCT01289262
50 Pelvic Pain in Women With Endometriosis Completed NCT00073801

Search NIH Clinical Center for Endometriosis of Uterus

Cochrane evidence based reviews: adenomyosis

Genetic Tests for Endometriosis of Uterus

Anatomical Context for Endometriosis of Uterus

MalaCards organs/tissues related to Endometriosis of Uterus:

Uterus, Bone, Testes, Pituitary, Brain, Bone Marrow

Publications for Endometriosis of Uterus

Variations for Endometriosis of Uterus

Expression for Endometriosis of Uterus

Search GEO for disease gene expression data for Endometriosis of Uterus.

Pathways for Endometriosis of Uterus

Pathways related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
Show member pathways
11.19 PRL PRLR
2 10.65 PRL PRLR
Show member pathways
10.24 PRL PRLR

GO Terms for Endometriosis of Uterus

Cellular components related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL PRLR

Biological processes related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.16 GNRH1 PRL
2 lactation GO:0007595 8.96 PRL PRLR
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 PRL PRLR

Molecular functions related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GNRH1 PRL

Sources for Endometriosis of Uterus

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
Loading form....