MCID: END021
MIFTS: 53

Endomyocardial Fibrosis malady

Categories: Rare diseases, Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Endomyocardial Fibrosis

About this section

Aliases & Descriptions for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 10 45 47 12 36 65
Obscure African Cardiomyopathy 10 65
Emf 40 2
African Endomyocardial Fibrosis 10
 
Becker Muscular Dystrophy 65
Endomyocardial Sclerosis 10
Becker's Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:12932
ICD9CM29 425.0
MeSH36 D004719
NCIt42 C34585
UMLS65 C0553980, C1959600, C0917713

Summaries for Endomyocardial Fibrosis

About this section
Wikipedia:68 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards based summary: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to malaria and rheumatoid arthritis, and has symptoms including weakness An important gene associated with Endomyocardial Fibrosis is DMD (Dystrophin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Hematopoietic cell lineage. Affiliated tissues include heart, bone and liver, and related mouse phenotypes are liver/biliary system and respiratory system.

CDC:2 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Related Diseases for Endomyocardial Fibrosis

About this section

Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1malaria29.5IL10, IL4, TNF
2rheumatoid arthritis29.2IL10, IL4, TNF
3tropical endomyocardial fibrosis12.3
4myotonia congenita, recessive11.3
5cycloplegia10.4IL10, IL4
6dysgammaglobulinemia10.4IL10, IL4
7dioctophymiasis10.4IL10, IL4
8penicillin allergy10.4IL10, IL4
9superficial urinary bladder cancer10.4IL10, IL4
10buruli ulcer10.4IL10, IL4
11cow milk allergy10.4IL10, IL4
12cardiomyopathy10.4
13enamel caries10.3IL10, IL4
14acalculous cholecystitis10.3IL10, IL4
15vernal conjunctivitis10.3IL10, IL4
16benign dermal neurilemmoma10.3IL10, IL4
17primary progressive multiple sclerosis10.3IL10, IL4
18hodgkin's lymphoma, nodular sclerosis10.3IL10, IL4
19gonococcal bursitis10.3IL4, TNF
20wissler's syndrome10.3IL10, IL4
21collagenous colitis10.3IL4, TNF
22heart disease10.3
23eosinophilia10.3
24hypereosinophilic syndrome10.3
25soft palate cancer10.3IL4, TNF
26hepatoid adenocarcinoma10.3IL4, TNF
27deafness, autosomal recessive 6210.3IL10, IL4
28submandibular gland disease10.2IL4, TNF
29punctate palmoplantar keratoderma type 210.2IL10, TNF
30pustulosis palmaris et plantaris10.2IL4, TNF
31multifocal lymphangioendotheliomatosis with thrombocytopenia10.2IL10, TNF
32alternating exotropia10.2IL10, TNF
33drug-induced mental disorder10.2IL10, TNF
34opisthorchiasis10.2IL10, TNF
35reflex sympathetic dystrophy10.2IL4, TNF
36precursor b lymphoblastic lymphoma/leukemia10.2IL10, TNF
37hypercementosis10.2IL10, TNF
38prostate transitional cell carcinoma10.2IL10, TNF
39moderately severe hemophilia a10.2IL10, TNF
40hydronephrosis10.2IL10, TNF
41streptococcal meningitis10.2IL10, TNF
42cytoplasmic body myopathy10.2IL10, TNF
43hemorrhagic proctocolitis10.2IL10, TNF
44leukoplakia of penis10.2IL4, TNF
45dancing eyes-dancing feet syndrome10.2IL10, TNF
46hemolytic anemia10.2IL10, TNF
47peripheral retinal degeneration10.2IL10, TNF
48idiopathic spinal cord herniation10.2IL10, TNF
49trench fever10.2IL10, TNF
50kernicterus due to isoimmunization10.2IL10, TNF

Comorbidity relations with Endomyocardial Fibrosis via Phenotypic Disease Network (PDN):


Acute CystitisFamilial Atrial Fibrillation
Heart DiseaseIschemic Heart Disease

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Symptoms for Endomyocardial Fibrosis

About this section

UMLS symptoms related to Endomyocardial Fibrosis:


weakness

Drugs & Therapeutics for Endomyocardial Fibrosis

About this section

Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 3, Phase 1206
2AntibodiesPhase 3, Phase 14477
3Immunologic FactorsPhase 3, Phase 118483
4Plasma SubstitutesPhase 3135
5ImmunoglobulinsPhase 3, Phase 14477
6Blood SubstitutesPhase 3148
7Immunoglobulins, IntravenousPhase 3, Phase 1211
8
SpironolactoneapprovedPhase 21591952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
9MineralocorticoidsPhase 2301
10Mineralocorticoid Receptor AntagonistsPhase 2284
11Natriuretic AgentsPhase 21403
12Hormone AntagonistsPhase 210002
13Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
14Diuretics, Potassium SparingPhase 21445
15diureticsPhase 21194
16HormonesPhase 211748
17Radiopharmaceuticals362
18
Iodine4947553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
19cadexomer iodine456
203-Iodobenzylguanidine60

Interventional clinical trials:

idNameStatusNCT IDPhase
1Intravenous Immunoglobulin (IVIg) for Parvovirus B19(PVB19) Mediated CardiomyopathyRecruitingNCT00892112Phase 3
2Spironolactone in Adult Congenital Heart DiseaseActive, not recruitingNCT01069510Phase 2
3IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral LoadRecruitingNCT00659386Phase 1
4The Genetic Basis of Acquired Heart Disease in AfricaRecruitingNCT02124109
5Left Atrial Volume Index in Asymptomatic Aortic StenosisRecruitingNCT02395107
6The Leiden Nonischemic Cardiomyopathy StudyRecruitingNCT01940081
7Assessment of Myocardial Fibrosis in Aortic STenosisActive, not recruitingNCT02316587
8Noninvasive Imaging of Heart Failure: A Pilot StudyActive, not recruitingNCT01160471

Search NIH Clinical Center for Endomyocardial Fibrosis


Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

About this section

Anatomical Context for Endomyocardial Fibrosis

About this section

MalaCards organs/tissues related to Endomyocardial Fibrosis:

33
Heart, Bone, Liver, Bone marrow, Breast, T cells, Prostate

Animal Models for Endomyocardial Fibrosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4DMD, IL10, IL4, TNF
2MP:00053888.3DMD, IL10, IL4, TNF
3MP:00107718.3CLCN1, IL10, IL4, TNF
4MP:00053818.2DMD, IL10, IL4, TNF
5MP:00053698.2CLCN1, DMD, IL10, TNF
6MP:00053897.8CLCN1, DMD, IL10, IL4, TNF
7MP:00053917.8CLCN1, DMD, IL10, IL4, TNF
8MP:00030127.7CLCN1, DMD, IL10, IL4, TNF
9MP:00036317.6CLCN1, DMD, IL10, IL4, TNF
10MP:00053907.5CLCN1, DMD, IL10, IL4, TNF
11MP:00053787.2CLCN1, DMD, IL10, IL4, TNF

Publications for Endomyocardial Fibrosis

About this section

Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
Restrictive cardiomyopathy as a result of endomyocardial fibrosis from hypereosinophilia. (25582942)
2015
2
The safety and efficacy of prednisolone in preventing reaccumulation of ascites among endomyocardial fibrosis patients in Uganda: a randomized clinical trial. (26666319)
2015
3
Predominant RV endomyocardial fibrosis masking rheumatic mitral stenosis. (25438498)
2014
4
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
5
Usefulness of cardiac MRI in the early diagnosis of endomyocardial fibrosis. (22503434)
2012
6
Systemic thromboembolism in endomyocardial fibrosis (EMF): clinical observations, aetio-pathogenesis and treatment. (21416790)
2010
7
Searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry. (19823676)
2009
8
Endomyocardial fibrosis mimicking Ebstein's anomaly: a diagnostic challenge. (19568399)
2009
9
Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis: myocardial disease. (18276824)
2008
10
Typical clinical aspect of endomyocardial fibrosis. (16257072)
2006
11
Pitfalls in diagnosis and clinical, echocardiographic, and hemodynamic findings in endomyocardial fibrosis: a 25-year experience. (16354870)
2005
12
Multiple microembolic borderzone brain infarctions and endomyocardial fibrosis in idiopathic hypereosinophilic syndrome and in Schistosoma mansoni infestation. (14742613)
2004
13
Endomyocardial fibrosis of right ventricle. (11163568)
2001
14
Endomyocardial fibrosis (Davies disease) coincidental with systemic lupus erythematosus. (10855412)
2000
15
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. (9588233)
1998
16
Endomyocardial fibrosis in Zimbabwe--how rare is it? A report of two cases. (8997819)
1996
17
Right-sided endomyocardial fibrosis with recurrent pulmonary emboli leading to irreversible pulmonary hypertension. (1389768)
1992
18
Echocardiographic findings in endomyocardial fibrosis. (1509530)
1992
19
A geochemical basis for endomyocardial fibrosis. (2598218)
1989
20
Effectiveness of operative and nonoperative therapy in endomyocardial fibrosis. (2711999)
1989
21
Surgical treatment of endomyocardial fibrosis. (3800484)
1987
22
Unusual echocardiographic appearance of intracardiac thrombi in a patient with endomyocardial fibrosis. (3730220)
1986
23
Postoperative evaluation of endomyocardial fibrosis. (3955583)
1986
24
Serum immunoglobulins in patients with endomyocardial fibrosis. (3447948)
1986
25
Immunohistological studies in endomyocardial fibrosis. (6373573)
1984
26
Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy. (6736450)
1984
27
Phonomechanocardiographic findings in endomyocardial fibrosis. (6696288)
1984
28
Endomyocardial fibrosis in Thai children. (6491562)
1984
29
Surgical palliation for endomyocardial fibrosis. (6695359)
1984
30
Endomyocardial fibrosis with successful surgical treatment in a Hungarian woman. (6617211)
1983
31
Technical aspects in surgery for endomyocardial fibrosis: experience with 37 patients. (15227123)
1983
32
Coronary angiographic features in endomyocardial fibrosis. (6193879)
1983
33
M-mode echocardiographic features of endomyocardial fibrosis. (7104113)
1982
34
Echocardiographic findings in endomyocardial fibrosis. (7083941)
1982
35
Relation of severe eosinophilia and microfilariasis to chronic African endomyocardial fibrosis. (7259917)
1981
36
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
37
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. (869976)
1977
38
Endomyocardial fibrosis and eosinophilia. (849383)
1977
39
Eosinophilia and endomyocardial fibrosis. (1258775)
1976
40
E.C.G. in endomyocardial fibrosis. (4425511)
1974
41
Morphogenesis of endomyocardial fibrosis. (4544107)
1973
42
The electrocardiogram in endomyocardial fibrosis. (5160381)
1971
43
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968
44
Endomyocardial fibrosis in a North American Negro. Probable familial incidence. (4175550)
1968
45
Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics. (4163977)
1967
46
Endomyocardial fibrosis in Uganda (Davies' disease). 1. An epidemiologic, clinical, and pathologic study. (4861733)
1967
47
ADULT ENDOMYOCARDIAL FIBROSIS IN BRITAIN. (14044273)
1963
48
The evolution of endomyocardial fibrosis. (14480770)
1962
49
Intracardiac calcification in endomyocardial fibrosis. (13915097)
1962
50

Variations for Endomyocardial Fibrosis

About this section

Clinvar genetic disease variations for Endomyocardial Fibrosis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DMDNM_004006.2(DMD): c.9G> A (p.Trp3Ter)single nucleotide variantPathogenicrs398122853GRCh37Chr X, 33229421: 33229421
2DMDNM_004006.2(DMD): c.10171C> T (p.Arg3391Ter)single nucleotide variantPathogenicrs398123832GRCh37Chr X, 31196838: 31196838
3DMDNM_004006.2(DMD): c.31+1G> Tsingle nucleotide variantPathogenicrs398123923GRCh37Chr X, 33229398: 33229398

Expression for genes affiliated with Endomyocardial Fibrosis

About this section
Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

About this section

Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3IL4, TNF
29.3IL4, TNF
39.1IL10, TNF
49.1IL10, TNF
59.1IL10, TNF
69.1IL10, TNF
79.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
99.0IL10, IL4
109.0IL10, IL4
119.0IL10, IL4
128.5IL10, IL4, TNF
138.5IL10, IL4, TNF
148.5IL10, IL4, TNF
15
Show member pathways
8.5IL10, IL4, TNF
168.5IL10, IL4, TNF
17
Show member pathways
8.5IL10, IL4, TNF
18
Show member pathways
8.5IL10, IL4, TNF
19
Show member pathways
8.1DMD, IL10, IL4, TNF

GO Terms for genes affiliated with Endomyocardial Fibrosis

About this section

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mononuclear cell migrationGO:007167710.0IL4, TNF
2positive regulation of chemokine biosynthetic processGO:00450809.9IL4, TNF
3receptor biosynthetic processGO:00328009.8IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
5negative regulation of growth of symbiont in hostGO:00441309.6IL10, TNF
6defense response to protozoanGO:00428329.6IL10, IL4
7negative regulation of interleukin-6 productionGO:00327159.6IL10, TNF
8type 2 immune responseGO:00420929.6IL10, IL4
9response to glucocorticoidGO:00513849.6IL10, TNF
10B cell differentiationGO:00301839.6IL10, IL4
11negative regulation of endothelial cell apoptotic processGO:20003529.5IL10, IL4
12positive regulation of protein phosphorylationGO:00019349.4IL4, TNF
13negative regulation of nitric oxide biosynthetic processGO:00450199.4IL10, IL4
14positive regulation of MHC class II biosynthetic processGO:00453489.4IL10, IL4
15response to organic substanceGO:00100339.1IL10, TNF
16defense response to bacteriumGO:00427429.0IL10, TNF
17positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL10, IL4, TNF
18positive regulation of transcription, DNA-templatedGO:00458938.8IL10, IL4, TNF
19immune responseGO:00069558.5IL10, IL4, TNF

Sources for Endomyocardial Fibrosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet