EMF
MCID: END021
MIFTS: 40

Endomyocardial Fibrosis (EMF) malady

Cardiovascular category

Summaries for Endomyocardial Fibrosis

Sources:
3CDC, 64Wikipedia, 33MalaCards
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Wikipedia:64 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to hypereosinophilic syndrome and tropical endomyocardial fibrosis. An important gene associated with Endomyocardial Fibrosis is CLCN1 (chloride channel, voltage-sensitive 1), and among its related pathways is Activation of cAMP-Dependent PKA. The compounds sodium and aspartate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are skeleton and muscle.

CDC:3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Aliases & Classifications for Endomyocardial Fibrosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 39NCBI Bookshelf, 40NCIt, 57SNOMED-CT, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

endomyocardial fibrosis 8 43 10 45 61
obscure african cardiomyopathy 8 61
african endomyocardial fibrosis 8
becker generalized myotonia 61
endomyocardial sclerosis 8
becker's disease 8
emf 39


External Ids:

Disease Ontology8 DOID:12932
NCIt40 C34585
MeSH35 D004719
ICD9CM27 425.0

Related Diseases for Endomyocardial Fibrosis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Clinical Features for Endomyocardial Fibrosis

Drugs & Therapeutics for Endomyocardial Fibrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Endomyocardial Fibrosis

Drug clinical trials:

Search ClinicalTrials for Endomyocardial Fibrosis

Search NIH Clinical Center for Endomyocardial Fibrosis

Search CenterWatch for Endomyocardial Fibrosis

Genetic Tests for Endomyocardial Fibrosis

Anatomical Context for Endomyocardial Fibrosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Endomyocardial Fibrosis:

33
Bone marrow, Brain, Heart, Skeletal muscle, Liver, Lung, B lymphoblasts

Animal Models for Endomyocardial Fibrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5ADRB1, CLCN1, SCXB, PDGFRA
2MP:00053698.2ADRB1, CLCN1, SCXB, PDGFRA

Publications for Endomyocardial Fibrosis

Sources:
51PubMed
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Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 419)
idTitleAuthorsYear
1
Massive Left Ventricular Calcification: Related to Endomyocardial Fibrosis or Idiopathic? Response. (24411979)
2014
2
Calcified apical cardiomyopathy: a rare form of endomyocardial fibrosis. (23751598)
2013
3
Recent advances in the epidemiology, diagnosis and treatment of endomyocardial fibrosis in Africa. (23680893)
2013
4
Combined endocardiectomy and bidirectional glenn shunt for right ventricular endomyocardial fibrosis. (22186457)
2012
5
The changing pattern of endomyocardial fibrosis in South-west Nigeria. (23226077)
2012
6
Spontaneous Fontan physiology in burnt-out endomyocardial fibrosis. (22294710)
2012
7
MR imaging of endomyocardial fibrosis (EMF). (19410309)
2011
8
Complementary roles of transthoracic two-dimensional color Doppler imaging and myocardial contrast echocardiography in diagnosis of endomyocardial fibrosis. (19452614)
2009
9
Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis: myocardial disease. (18276824)
2008
10
Images in cardiovascular medicine: Cardiac magnetic resonance imaging and eosinophilic endomyocardial fibrosis. (19047586)
2008
11
Deficiency of mannose-binding lectin, myopathy, calcified endomyocardial fibrosis, and left ventricular noncompaction. (18992631)
2008
12
A population study of endomyocardial fibrosis in a rural area of Mozambique. (18596273)
2008
13
An innovative technique for the relief of right ventricular trabecular cavity obliteration in endomyocardial fibrosis. (17903544)
2007
14
Typical clinical aspect of endomyocardial fibrosis. (16257072)
2006
15
Endomyocardial fibrosis in Churg-Strauss syndrome assessed by cardiac magnetic resonance imaging. (16516704)
2006
16
Endomyocardial fibrosis and intracardiac thrombus occurring in idiopathic hypereosinophilic syndrome. (15855091)
2005
17
Echocardiographic profile of endomyocardial fibrosis in Tanzania, East Africa. (16411343)
2004
18
Bidirectional cavopulmonary shunt as a rescue procedure for right ventricular endomyocardial fibrosis. (17670184)
2004
19
New approach for complete endocardiectomy in left ventricular endomyocardial fibrosis. (12538982)
2003
20
Endomyocardial fibrosis (Davies disease) coincidental with systemic lupus erythematosus. (10855412)
2000
21
Mital valve disease with rheumatic appearance in the presence of left ventricular endomyocardial fibrosis. (10513044)
1999
22
Atrial fibrillation in endomyocardial fibrosis is a marker of worse prognosis. (9880197)
1998
23
Long-term follow up of patients with endomyocardial fibrosis: effects of surgery. (9616343)
1998
24
Endomyocardial fibrosis in BehAset's disease. (9135228)
1997
25
Endomyocardial fibrosis in Egypt: an illustrated review. (9155633)
1997
26
Endomyocardial fibrosis, a case for the tropical doctor. (8595606)
1995
27
Successful reduction of endomyocardial fibrosis in a patient with idiopathic hypereosinophilic syndrome. A case report. (7726456)
1995
28
Endomyocardial fibrosis in the child. (2913724)
1989
29
Unusual presentation of endomyocardial fibrosis. (3170044)
1988
30
Echocardiographic recognition of Chagas' disease and endomyocardial fibrosis. (3078542)
1988
31
Unusual echocardiographic appearance of intracardiac thrombi in a patient with endomyocardial fibrosis. (3566991)
1987
32
Detection of endocardial calcium in endomyocardial fibrosis by computed tomography. (3618513)
1987
33
Unusual echocardiographic appearance of intracardiac thrombi in a patient with endomyocardial fibrosis. (3730220)
1986
34
Increase in extracellular matrix components & absence of eosinophil granule protein in heart tissue affected with endomyocardial fibrosis. (3759173)
1986
35
Endomyocardial fibrosis. Diagnosis and surgical treatment of two cases occurring in the United States. (3742811)
1986
36
Endomyocardial fibrosis: report on the hemodynamic data in 29 patients and review of the results of surgery. (6340450)
1983
37
Endomyocardial fibrosis: diagnosis and treatment. (6837430)
1983
38
Enzymes of collagen synthesis and type III procollagen amino-propeptide in serum from Nigerians with chronic endomyocardial fibrosis. (6314867)
1983
39
Endomyocardial fibrosis with aortic, mitral, and tricuspid valve involvement. (7125775)
1982
40
Ecology of endomyocardial fibrosis in Kerala State. (7409844)
1980
41
Pre- and postoperative findings in patients with endomyocardial fibrosis. (646908)
1978
42
Endomyocardial fibrosis and eosinophilia. (849383)
1977
43
Endomyocardial fibrosis in Chandigarh area, India. A study of nine autopsies. (147537)
1977
44
A case of diffuse endomyocardial fibrosis of the right ventricle with persistent pericardial effusion. (1011370)
1976
45
Studies on the experimental production of endomyocardial fibrosis and cardiomegaly of unknown origin by dietary means. (125535)
1975
46
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968
47
Clinical features of endomyocardial fibrosis of the right ventricle. (5656835)
1968
48
Idiopathic cardiomegaly and endomyocardial fibrosis. (4231750)
1968
49
ENDOMYOCARDIAL FIBROSIS IN BRITAIN. (14245203)
1965
50
An unusual form of heart-disease in West Africa; its relation to endomyocardial fibrosis. (13791541)
1959

Genetic Variations for Endomyocardial Fibrosis

Expression for genes affiliated with Endomyocardial Fibrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

Sources:
52QIAGEN
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Pathways related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ADRB1, CLCN1, PDGFRA

Compounds for genes affiliated with Endomyocardial Fibrosis

Sources:
45Novoseek, 24HMDB
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Compounds related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium45 2410.1ADRB1, CLCN1, MBL2
2aspartate458.7PDGFRA, MBL2, ADRB1
3tyrosine458.5ADRB1, FIP1L1, MBL2, PDGFRA

GO Terms for genes affiliated with Endomyocardial Fibrosis

Sources:
16Gene Ontology
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Biological processes related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:0420609.4ADRB1, PDGFRA

Products for genes affiliated with Endomyocardial Fibrosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endomyocardial Fibrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet