MCID: END021
MIFTS: 47

Endomyocardial Fibrosis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Endomyocardial Fibrosis

MalaCards integrated aliases for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 12 50 52 42 14 69
Obscure African Cardiomyopathy 12 69
Emf 45 3
African Endomyocardial Fibrosis 12
Becker Muscular Dystrophy 69
Endomyocardial Sclerosis 12
Becker's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12932
ICD9CM 35 425.0
MeSH 42 D004719
NCIt 47 C34585
UMLS 69 C0553980

Summaries for Endomyocardial Fibrosis

CDC : 3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

MalaCards based summary : Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to churg-strauss syndrome and ulcerative colitis, and has symptoms including weakness An important gene associated with Endomyocardial Fibrosis is CLCN1 (Chloride Voltage-Gated Channel 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are integument and craniofacial

Wikipedia : 72 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

Related Diseases for Endomyocardial Fibrosis

Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
id Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 30.0 IL10 IL4 TNF
2 ulcerative colitis 30.0 IL10 TNF
3 lymphoma 29.5 IL10 IL4 TNF
4 budd-chiari syndrome 29.3 FIP1L1 PDGFRA
5 rheumatoid arthritis 28.9 IL10 IL4 TNF
6 tropical endomyocardial fibrosis 12.1
7 urethral intrinsic sphincter deficiency 10.5 IL4 TNF
8 lymphocytic colitis 10.5 IL4 TNF
9 acute vascular insufficiency of intestine 10.5 IL4 TNF
10 reardon wilson cavanagh syndrome 10.5 IL4 TNF
11 eye accommodation disease 10.5 IL10 IL4
12 diabetic angiopathy 10.5 IL10 IL4
13 thelaziasis 10.5 IL10 IL4
14 deafness, autosomal recessive 22 10.4 IL10 IL4
15 mikulicz disease 10.4 IL4 TNF
16 cherry allergy 10.4 IL10 IL4
17 cow milk allergy 10.4 IL10 IL4
18 centronuclear myopathy 5 10.4 IL10 IL4
19 pure autonomic failure 10.4 IL10 TNF
20 bardet-biedl syndrome 15 10.4 IL10 IL4
21 vascular dementia 10.4 IL10 IL4
22 multiple familial trichoepithelioma 10.4 IL10 TNF
23 type 1 papillary adenoma of the kidney 10.4 IL10 TNF
24 nut allergy 10.4 IL10 IL4
25 endosalpingiosis 10.4 IL10 TNF
26 idiopathic dilatation of the pulmonary artery 10.4 IL10 TNF
27 ethmoid sinus adenocarcinoma 10.4 IL10 TNF
28 tarsal tunnel syndrome 10.4 IL10 TNF
29 plantar wart 10.4 IL10 TNF
30 loiasis 10.4 IL10 IL4
31 legionellosis 10.4 IL4 TNF
32 chronic apical periodontitis 10.4 IL10 TNF
33 tricho onychic dysplasia 10.4 IL10 TNF
34 eyelid neoplasm 10.4 IL10 IL4
35 cyclosporiasis 10.4 IL10 TNF
36 urethra transitional cell carcinoma 10.4 IL10 TNF
37 status epilepticus 10.4 IL4 TNF
38 primary biliary cirrhosis 10.4 IL10 TNF
39 hepadnavirus infection 10.4 IL10 TNF
40 senile reticular retinal degeneration 10.4 IL10 TNF
41 ovarian endometrioid cystadenoma 10.4 IL10 IL4
42 psychologic dyspareunia 10.4 IL10 TNF
43 hemophagocytic lymphohistiocytosis 10.4 IL10 TNF
44 erythema infectiosum 10.4 IL4 TNF
45 cryptococcosis 10.4 IL10 TNF
46 megaloblastic anemia 10.4 IL10 TNF
47 dysphagia 10.4 IL10 TNF
48 conduct disorder 10.4 IL10 TNF
49 bartonellosis 10.4 IL10 TNF
50 eye carcinoma in situ 10.4 IL4 TNF

Comorbidity relations with Endomyocardial Fibrosis via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to Endomyocardial Fibrosis

Symptoms & Phenotypes for Endomyocardial Fibrosis

UMLS symptoms related to Endomyocardial Fibrosis:


weakness

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.65 CLCN1 IL10 IL4 PDGFRA TNF
2 craniofacial MP:0005382 9.62 IL10 IL4 PDGFRA TNF
3 no phenotypic analysis MP:0003012 9.55 CLCN1 IL10 IL4 PDGFRA TNF
4 reproductive system MP:0005389 9.35 CLCN1 IL10 IL4 PDGFRA TNF
5 skeleton MP:0005390 9.02 CLCN1 IL10 IL4 PDGFRA TNF

Drugs & Therapeutics for Endomyocardial Fibrosis

Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
2 diuretics Phase 2
3 Mineralocorticoid Receptor Antagonists Phase 2
4 Mineralocorticoids Phase 2
5 Natriuretic Agents Phase 2
6 Hormone Antagonists Phase 2
7 Hormones Phase 2
8 Diuretics, Potassium Sparing Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10 Rho(D) Immune Globulin Phase 1
11 gamma-Globulins Phase 1
12 Immunoglobulins Phase 1
13 Immunoglobulins, Intravenous Phase 1
14 Antibodies Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Spironolactone in Adult Congenital Heart Disease Completed NCT01069510 Phase 2 Spironolactone
2 IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load Unknown status NCT00659386 Phase 1 Intravenous immunoglobulin therapy
3 Assessment of Myocardial Fibrosis in Aortic STenosis Completed NCT02316587
4 Left Atrial Volume Index in Asymptomatic Aortic Stenosis Completed NCT02395107
5 Noninvasive Imaging of Heart Failure: A Pilot Study Completed NCT01160471
6 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109
7 Magnetic Resonance Imaging and Fibrosis Recruiting NCT02790008

Search NIH Clinical Center for Endomyocardial Fibrosis

Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

Anatomical Context for Endomyocardial Fibrosis

MalaCards organs/tissues related to Endomyocardial Fibrosis:

39
Heart, Bone, Bone Marrow, Skin, Lung, Skeletal Muscle, Brain

Publications for Endomyocardial Fibrosis

Articles related to Endomyocardial Fibrosis:

(show top 50) (show all 472)
id Title Authors Year
1
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
2
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ( 28890659 )
2017
3
LAPffler Endocarditis and Endomyocardial Fibrosis. ( 28846127 )
2017
4
The key clues to reach the diagnosis of Loeffler endomyocardial fibrosis associated with eosinophilic granulomatosis with polyangiitis. ( 28072629 )
2017
5
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2017
6
Endomyocardial fibrosis in Sudan: clinical and echocardiographic features. ( 28906536 )
2017
7
Ventricular endomyocardial fibrosis in a pregnant female with BehAset's disease. ( 28068787 )
2017
8
Diagnosis and Management of Endomyocardial Fibrosis. ( 27886792 )
2017
9
Severe Left Ventricular Endomyocardial Fibrosis Presenting as Biventricular Failure in a Young Adult: A Case Report. ( 28050425 )
2016
10
A Rare Case of Mitral Valve Prolapse in Endomyocardial Fibrosis. ( 27549547 )
2016
11
Bundle branch reentry: A rare mechanism of ventricular tachycardia in endomyocardial fibrosis, without ventricular dilation. ( 27751288 )
2016
12
A Challenging Differential Diagnosis: Distinguishing between Endomyocardial Fibrosis and Apical Hypertrophic Cardiomyopathy. ( 27144839 )
2016
13
Coexistence of apical hypertrophic cardiomyopathy and endomyocardial fibrosis with calcification: diagnosis using multimodality imaging. ( 27867529 )
2016
14
Doughnut appearance of left ventricle in isolated left ventricular endomyocardial fibrosis. ( 27751273 )
2016
15
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
16
A case of biventricular endomyocardial fibrosis complicated by right ventricular outflow tract aneurysms. ( 27245722 )
2016
17
Active schistosomiasis, severe hypereosinophilia and rapid progression of chronic endomyocardial fibrosis. ( 27805245 )
2016
18
Idiopathic Hypereosinophilic Syndrome Associated with Endomyocardial Fibrosis, Intracardiac Thrombi, Pulmonary and Skin Infiltration: A Case Report. ( 27617583 )
2016
19
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
20
Endomyocardial Fibrosis Associated With Apical Calcification and High Uptake on Myocardial Gallium-67 Scintigraphy. ( 27477847 )
2016
21
Endomyocardial fibrosis with right ventricular aneurysm mimicking ARVC - A case report from India. ( 27751343 )
2016
22
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
23
Endomyocardial fibrosis: missing tricuspid valve and Fontan-like circulation. ( 26747439 )
2016
24
Rare association of endomyocardial fibrosis and Chagas heart disease. ( 28031230 )
2016
25
Unusual endomyocardial fibrosis with apical calcification. ( 26066548 )
2015
26
Restrictive cardiomyopathy as a result of endomyocardial fibrosis from hypereosinophilia. ( 25582942 )
2015
27
Isolated Severe Right Ventricle Endomyocardial Fibrosis in a Child: Vanishing Tropical Disease Revisited. ( 26578670 )
2015
28
Cardiac MRI findings of endomyocardial fibrosis (Loeffler's endocarditis) in a patient with rheumatoid arthritis. ( 25870507 )
2015
29
The safety and efficacy of prednisolone in preventing reaccumulation of ascites among endomyocardial fibrosis patients in Uganda: a randomized clinical trial. ( 26666319 )
2015
30
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2015
31
Left ventricular calcification in a patient with endomyocardial fibrosis. ( 26626444 )
2015
32
Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia. ( 26492057 )
2015
33
Case 3/2015 - 53-Year-Old Female with Cardiogenic Shock 12 Years after Surgical Correction of Endomyocardial Fibrosis. ( 26466072 )
2015
34
Endomyocardial fibrosis and mural thrombus in a 4-year-old girl due to idiopathic hypereosinophilia syndrome described with serial cardiac magnetic resonance imaging. ( 25683059 )
2015
35
Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report. ( 26266372 )
2015
36
Endomyocardial fibrosis in Sub Saharan Africa: The geographical origin, socioeconomic status, and dietary habits of cases reported in Yaounde, Cameroon. ( 26556966 )
2015
37
Endomyocardial fibrosis (EMF) in a Ugandan child with advanced hepatosplenic schistosomiasis: coincidence or connection? ( 25002295 )
2014
38
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. ( 24158754 )
2014
39
Endomyocardial fibrosis associated with Schistosoma haematobium infection. ( 25709139 )
2014
40
Forme fruste of isolated right ventricular endomyocardial fibrosis: a case report. ( 24612874 )
2014
41
Cardiac magnetic resonance imaging for the diagnosis of endomyocardial fibrosis. ( 25417517 )
2014
42
Cardiac magnetic resonance imaging for the diagnosis of endomyocardial fibrosis. ( 25507245 )
2014
43
Plasma Cytokine Profile in Tropical Endomyocardial Fibrosis: Predominance of TNF-a, IL-4 and IL-10. ( 25303100 )
2014
44
The 'V' Sign of Endomyocardial Fibrosis. ( 25288777 )
2014
45
Predominant RV endomyocardial fibrosis masking rheumatic mitral stenosis. ( 25438498 )
2014
46
Genetic susceptibility to endomyocardial fibrosis. ( 25780800 )
2014
47
Massive left ventricular calcification: related to endomyocardial fibrosis or idiopathic? Response. ( 24795138 )
2014
48
Right ventricular endomyocardial fibrosis mimicking Ebstein anomaly in a patient with BehAset's disease: case report and review of the literature. ( 24533554 )
2014
49
Massive left ventricular calcification: related to endomyocardial fibrosis or idiopathic? ( 24795136 )
2014
50
Republished: Recent advances in the epidemiology, diagnosis and treatment of endomyocardial fibrosis in Africa. ( 24336311 )
2014

Variations for Endomyocardial Fibrosis

Expression for Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for Endomyocardial Fibrosis

Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 IL10 IL4 PDGFRA TNF
2
Show member pathways
12.98 IL10 IL4 PDGFRA TNF
3
Show member pathways
12.45 IL10 IL4 PDGFRA TNF
4
Show member pathways
12.35 IL10 IL4 TNF
5
Show member pathways
12.31 IL10 IL4 TNF
6
Show member pathways
12.29 IL10 PDGFRA TNF
7 12.24 IL10 IL4 TNF
8
Show member pathways
12.1 IL10 IL4 TNF
9
Show member pathways
11.93 IL10 IL4 TNF
10
Show member pathways
11.82 IL10 IL4 TNF
11 11.61 IL10 IL4 TNF
12 11.55 IL10 IL4 TNF
13 11.43 IL10 IL4
14 11.42 IL4 TNF
15 11.34 IL10 IL4 TNF
16 11.31 PDGFRA TNF
17 11.29 IL10 TNF
18 11.25 IL10 IL4
19 11.18 IL10 IL4 TNF
20
Show member pathways
11.16 IL10 TNF
21 11.09 IL10 TNF
22 11.08 IL10 TNF
23 11.03 IL4 TNF
24 10.91 IL10 IL4
25 10.86 IL10 IL4 TNF
26 10.82 IL10 IL4 TNF
27 10.28 IL10 IL4 TNF

GO Terms for Endomyocardial Fibrosis

Cellular components related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 IL4 PDGFRA TNF

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.61 IL10 IL4 TNF
2 response to glucocorticoid GO:0051384 9.6 IL10 TNF
3 B cell differentiation GO:0030183 9.59 IL10 IL4
4 cellular response to amino acid stimulus GO:0071230 9.58 PDGFRA TNF
5 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TNF
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.57 IL10 IL4
7 positive regulation of cytokine secretion GO:0050715 9.56 IL10 TNF
8 negative regulation of interleukin-6 production GO:0032715 9.55 IL10 TNF
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.54 IL10 TNF
10 defense response to protozoan GO:0042832 9.52 IL10 IL4
11 negative regulation of nitric oxide biosynthetic process GO:0045019 9.51 IL10 IL4
12 negative regulation of growth of symbiont in host GO:0044130 9.49 IL10 TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL10 TNF
14 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL4 TNF
15 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL10 IL4
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
18 type 2 immune response GO:0042092 9.26 IL10 IL4
19 regulation of isotype switching GO:0045191 9.16 IL10 IL4
20 positive regulation of mononuclear cell migration GO:0071677 8.96 IL4 TNF
21 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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