EMF
MCID: END021
MIFTS: 42

Endomyocardial Fibrosis (EMF) malady

Cardiovascular diseases category

Summaries for Endomyocardial Fibrosis

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Sources:
3CDC, 63Wikipedia, 32MalaCards
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Wikipedia:63 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to eosinophilia and pulmonary fibrosis. An important gene associated with Endomyocardial Fibrosis is CLCN1 (chloride channel, voltage-sensitive 1), and among its related pathways is Activation of cAMP-Dependent PKA. The compounds sodium and aspartate have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related mouse phenotypes are skeleton and muscle.

CDC:3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Aliases & Classifications for Endomyocardial Fibrosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 38NCBI Bookshelf, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

endomyocardial fibrosis 8 42 10 44 60
obscure african cardiomyopathy 8 60
african endomyocardial fibrosis 8
becker generalized myotonia 60
endomyocardial sclerosis 8
becker's disease 8
emf 38


External Ids:

Disease Ontology8 DOID:12932
NCIt39 C34585
MeSH34 D004719
ICD9CM27 425.0

Related Diseases for Endomyocardial Fibrosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Clinical Features for Endomyocardial Fibrosis

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Drugs & Therapeutics for Endomyocardial Fibrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endomyocardial Fibrosis

Drug clinical trials:

Search ClinicalTrials for Endomyocardial Fibrosis

Search NIH Clinical Center for Endomyocardial Fibrosis

Search CenterWatch for Endomyocardial Fibrosis

Genetic Tests for Endomyocardial Fibrosis

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Anatomical Context for Endomyocardial Fibrosis

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32MalaCards
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MalaCards organs/tissues related to Endomyocardial Fibrosis:

32
Heart, Bone, Bone marrow, Liver, Brain, Lung, Skeletal muscle

Animal Models for Endomyocardial Fibrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5ADRB1, CLCN1, SCXB, PDGFRA
2MP:00053698.2ADRB1, CLCN1, SCXB, PDGFRA

Publications for Endomyocardial Fibrosis

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50PubMed
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Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 419)
idTitleAuthorsYear
1
Atypical cardiac magnetic resonance findings in a case of suspected endomyocardial fibrosis. (22619356)
2012
2
Presence of circulating anti-myosin antibodies in endomyocardial fibrosis. (20422043)
2010
3
Right ventricular endomyocardial fibrosis presenting with ventricular tachycardia and apical thrombus--an interesting presentation. (19898660)
2009
4
Emergency surgical treatment of advanced endomyocardial fibrosis in Mozambique. (19190586)
2009
5
Endomyocardial fibrosis: an enigmatic cause for a giant left atrium. (19299304)
2009
6
Endomyocardial fibrosis. (19323018)
2009
7
Endomyocardial fibrosis in an adult mimicking left ventricular mass. (18721604)
2008
8
Ascites in tropical endomyocardial fibrosis. (18069682)
2007
9
Hydropneumopericardium in endomyocardial fibrosis. (16725073)
2006
10
Angina-like chest pain and syncope as the clinical presentation of left ventricular endomyocardial fibrosis: a case report. (15889204)
2005
11
Multiple microembolic borderzone brain infarctions and endomyocardial fibrosis in idiopathic hypereosinophilic syndrome and in Schistosoma mansoni infestation. (14742613)
2004
12
Adenocarcinoma of the cecum as the first manifestation of ulcerative colitis complicated by primary sclerosing cholangitis and endomyocardial fibrosis. (12131613)
2002
13
Bidirectional Glenn shunt for right ventricular endomyocardial fibrosis. (12538287)
2002
14
Endomyocardial fibrosis of right ventricle. (11163568)
2001
15
Elevated levels of cerium in tubers from regions endemic for endomyocardial fibrosis (EMF). (9484572)
1998
16
Accumulation of glycosaminoglycans associated with hypomagnesaemia in endomyocardial fibrosis in Kerala: possible involvement of dietary factors. (9130425)
1997
17
Endomyocardial fibrosis and eosinophilia. (7901544)
1993
18
Right-sided endomyocardial fibrosis with recurrent pulmonary emboli leading to irreversible pulmonary hypertension. (1389768)
1992
19
Histomorphologic characteristics of endomyocardial fibrosis: an endomyocardial biopsy study. (2351390)
1990
20
The role of thorium in endomyocardial fibrosis. (2187497)
1990
21
Endomyocardial fibrosis and the tuberous diet. (2262213)
1990
22
Pattern of cardiac calcification in tropical endomyocardial fibrosis. (2093711)
1990
23
Right ventricular endomyocardial fibrosis. Diagnosis and management. (2214135)
1990
24
A geochemical basis for endomyocardial fibrosis. (3791358)
1986
25
Results, indications and contra-indications of surgery in restrictive endomyocardial fibrosis: comparative study on 31 operated and 30 non-operated patients. (4017915)
1985
26
Coronary angiographic features in endomyocardial fibrosis. (6193879)
1983
27
Endomyocardial fibrosis in rats treated with N-nitrosomorpholine. (6412445)
1983
28
Surgical palliation for endomyocardial fibrosis: early results. (6192513)
1983
29
Endomyocardial fibrosis in Kerala State. (6926987)
1982
30
A comparison of the clinical, haemodynamic and angiographic features in right ventricular endomyocardial fibrosis and Ebstein's anomaly of the tricuspid valve. (7172172)
1982
31
Loasis as a possible trigger of African endomyocardial fibrosis: a case report from Nigeria. (6115557)
1981
32
Endomyocardial fibrosis in Kerala State. (7309046)
1980
33
Endomyocardial fibrosis from a surgical standpoint. (7412349)
1980
34
Endomyocardial fibrosis and rheumatic heart disease in Mozambique. (538807)
1979
35
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
36
Serial electrocardiograms in endomyocardial fibrosis. (726650)
1978
37
Endomyocardial fibrosis in a European woman and its successful surgical treatment. (916720)
1977
38
Pericardioperitoneal shunt for massive recurrent pericardial effusion in patients with endomyocardial fibrosis. (893014)
1977
39
Endomyocardial fibrosis. (1018141)
1976
40
Hemodynamics in endomyocardial fibrosis. (4852243)
1974
41
Eosinophilia and endomyocardial fibrosis. (4664250)
1972
42
Heart valve involvement in endomyocardial fibrosis. (5086975)
1972
43
Endomyocardial fibrosis in Tanzania (mainland). (5426966)
1970
44
Plantain diets, serotonin, and endomyocardial fibrosis. (6019204)
1967
45
Endomyocardial fibrosis. (5849579)
1965
46
ENDOMYOCARDIAL FIBROSIS. (A REPORT OF TWO CASES IN BROTHERS). (14253382)
1964
47
ENDOMYOCARDIAL FIBROSIS IN TWO BROTHERS. (14063017)
1963
48
The evolution of endomyocardial fibrosis. (14480770)
1962
49
CLINICAL AND HAEMODYNAMIC PATTERNS IN ENDOMYOCARDIAL FIBROSIS. (18610159)
1961
50
Endomyocardial fibrosis. (13400853)
1957

Genetic Variations for Endomyocardial Fibrosis

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Expression for genes affiliated with Endomyocardial Fibrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

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51QIAGEN
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Pathways related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ADRB1, CLCN1, PDGFRA

Compounds for genes affiliated with Endomyocardial Fibrosis

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Sources:
44Novoseek, 24HMDB
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Compounds related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium44 2410.1ADRB1, CLCN1, MBL2
2aspartate448.7PDGFRA, MBL2, ADRB1
3tyrosine448.5ADRB1, FIP1L1, MBL2, PDGFRA

GO Terms for genes affiliated with Endomyocardial Fibrosis

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16Gene Ontology
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Biological processes related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:0420609.4ADRB1, PDGFRA

Products for genes affiliated with Endomyocardial Fibrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endomyocardial Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet