EMF
MCID: END021
MIFTS: 46

Endomyocardial Fibrosis (EMF) malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Endomyocardial Fibrosis

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Sources:
4CDC, 65Wikipedia, 33MalaCards
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Wikipedia:65 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to hypereosinophilic syndrome and eosinophilia. An important gene associated with Endomyocardial Fibrosis is CLCN1 (chloride channel, voltage-sensitive 1), and among its related pathways are NFAT and Cardiac Hypertrophy and Endocytosis. The compounds valine and sodium have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain, and related mouse phenotypes are no phenotypic analysis and skeleton.

CDC:4 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Aliases & Classifications for Endomyocardial Fibrosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 39NCBI Bookshelf, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

endomyocardial fibrosis 8 43 10 45 62
obscure african cardiomyopathy 8 62
african endomyocardial fibrosis 8
becker generalized myotonia 62
endomyocardial sclerosis 8
becker's disease 8
emf 39


External Ids:

Disease Ontology8 DOID:12932
ICD9CM27 425.0
NCIt40 C34585
MeSH35 D004719

Related Diseases for Endomyocardial Fibrosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Symptoms for Endomyocardial Fibrosis

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Drugs & Therapeutics for Endomyocardial Fibrosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Endomyocardial Fibrosis

Search NIH Clinical Center for Endomyocardial Fibrosis

Genetic Tests for Endomyocardial Fibrosis

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Anatomical Context for Endomyocardial Fibrosis

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33MalaCards
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MalaCards organs/tissues related to Endomyocardial Fibrosis:

33
Heart, Liver, Brain, Lung, Skeletal muscle

Animal Models for Endomyocardial Fibrosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.0CLCN1, ADRB1, PDGFRA
2MP:00053909.0CLCN1, ADRB1, PDGFRA
3MP:00053698.7PDGFRA, ADRB1, CLCN1
4MP:00053768.3CLCN1, ADRB1, PDGFRA, MBL2

Publications for Endomyocardial Fibrosis

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52PubMed
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Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
2
Usefulness of cardiac MRI in the early diagnosis of endomyocardial fibrosis. (22503434)
2012
3
Systemic thromboembolism in endomyocardial fibrosis (EMF): clinical observations, aetio-pathogenesis and treatment. (21416790)
2010
4
Searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry. (19823676)
2009
5
Endomyocardial fibrosis mimicking Ebstein's anomaly: a diagnostic challenge. (19568399)
2009
6
Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis: myocardial disease. (18276824)
2008
7
Typical clinical aspect of endomyocardial fibrosis. (16257072)
2006
8
Pitfalls in diagnosis and clinical, echocardiographic, and hemodynamic findings in endomyocardial fibrosis: a 25-year experience. (16354870)
2005
9
Multiple microembolic borderzone brain infarctions and endomyocardial fibrosis in idiopathic hypereosinophilic syndrome and in Schistosoma mansoni infestation. (14742613)
2004
10
Endomyocardial fibrosis of right ventricle. (11163568)
2001
11
Endomyocardial fibrosis (Davies disease) coincidental with systemic lupus erythematosus. (10855412)
2000
12
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. (9588233)
1998
13
Endomyocardial fibrosis in Zimbabwe--how rare is it? A report of two cases. (8997819)
1996
14
Right-sided endomyocardial fibrosis with recurrent pulmonary emboli leading to irreversible pulmonary hypertension. (1389768)
1992
15
Echocardiographic findings in endomyocardial fibrosis. (1509530)
1992
16
A geochemical basis for endomyocardial fibrosis. (2598218)
1989
17
Effectiveness of operative and nonoperative therapy in endomyocardial fibrosis. (2711999)
1989
18
Surgical treatment of endomyocardial fibrosis. (3800484)
1987
19
Unusual echocardiographic appearance of intracardiac thrombi in a patient with endomyocardial fibrosis. (3730220)
1986
20
Postoperative evaluation of endomyocardial fibrosis. (3955583)
1986
21
Serum immunoglobulins in patients with endomyocardial fibrosis. (3447948)
1986
22
Immunohistological studies in endomyocardial fibrosis. (6373573)
1984
23
Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy. (6736450)
1984
24
Phonomechanocardiographic findings in endomyocardial fibrosis. (6696288)
1984
25
Endomyocardial fibrosis in Thai children. (6491562)
1984
26
Surgical palliation for endomyocardial fibrosis. (6695359)
1984
27
Endomyocardial fibrosis with successful surgical treatment in a Hungarian woman. (6617211)
1983
28
Technical aspects in surgery for endomyocardial fibrosis: experience with 37 patients. (15227123)
1983
29
Coronary angiographic features in endomyocardial fibrosis. (6193879)
1983
30
Endomyocardial fibrosis masquerading as rheumatic mitral incompetence. A report of six surgical cases. (6632949)
1983
31
M-mode echocardiographic features of endomyocardial fibrosis. (7104113)
1982
32
Echocardiographic findings in endomyocardial fibrosis. (7083941)
1982
33
Relation of severe eosinophilia and microfilariasis to chronic African endomyocardial fibrosis. (7259917)
1981
34
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
35
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. (869976)
1977
36
Endomyocardial fibrosis and eosinophilia. (849383)
1977
37
Eosinophilia and endomyocardial fibrosis. (1258775)
1976
38
Endomyocardial fibrosis. Problems in differential diagnosis. (131566)
1976
39
E.C.G. in endomyocardial fibrosis. (4425511)
1974
40
Morphogenesis of endomyocardial fibrosis. (4544107)
1973
41
Immunoglobulins and antibody to Loa loa in Nigerians with endomyocardial fibrosis and other heart diseases. (4625267)
1972
42
The electrocardiogram in endomyocardial fibrosis. (5160381)
1971
43
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968
44
Endomyocardial fibrosis in a North American Negro. Probable familial incidence. (4175550)
1968
45
Necropsy study of endomyocardial fibrosis and rheumatic heart disease in Uganda 1950-1965. (5651254)
1968
46
Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics. (4163977)
1967
47
Endomyocardial fibrosis in Uganda (Davies' disease). 1. An epidemiologic, clinical, and pathologic study. (4861733)
1967
48
ADULT ENDOMYOCARDIAL FIBROSIS IN BRITAIN. (14044273)
1963
49
The evolution of endomyocardial fibrosis. (14480770)
1962
50
Intracardiac calcification in endomyocardial fibrosis. (13915097)
1962

Variations for Endomyocardial Fibrosis

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Expression for genes affiliated with Endomyocardial Fibrosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

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50PathCards, 53QIAGEN, 30KEGG
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Pathways related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4PDGFRA, ADRB1
29.4PDGFRA, ADRB1
39.4ADRB1, PDGFRA
4
Show member pathways
9.4PDGFRA, ADRB1
5
Show member pathways
9.0PDGFRA, ADRB1, CLCN1

Compounds for genes affiliated with Endomyocardial Fibrosis

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank
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Compounds related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1valine459.3MBL2, ADRB1
2sodium45 249.9MBL2, ADRB1, CLCN1
3imatinib45 51 1110.8PDGFRA, FIP1L1
4aspartate458.7ADRB1, PDGFRA, MBL2
5tyrosine458.0MBL2, PDGFRA, FIP1L1, ADRB1

GO Terms for genes affiliated with Endomyocardial Fibrosis

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16Gene Ontology
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Cellular components related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.0PDGFRA, ADRB1, CLCN1

Biological processes related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:0420609.4PDGFRA, ADRB1

Products for genes affiliated with Endomyocardial Fibrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endomyocardial Fibrosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet