EMF
MCID: END021
MIFTS: 42

Endomyocardial Fibrosis (EMF) malady

Cardiovascular diseases category

Summaries for Endomyocardial Fibrosis

About this section
Sources:
3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to eosinophilia and pulmonary fibrosis. An important gene associated with Endomyocardial Fibrosis is CLCN1 (chloride channel, voltage-sensitive 1), and among its related pathways is Activation of cAMP-Dependent PKA. The compounds sodium and aspartate have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and bone, and related mouse phenotypes are skeleton and muscle.

CDC:3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Aliases & Classifications for Endomyocardial Fibrosis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 38NCBI Bookshelf, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

endomyocardial fibrosis 8 42 10 44 60
obscure african cardiomyopathy 8 60
african endomyocardial fibrosis 8
becker generalized myotonia 60
endomyocardial sclerosis 8
becker's disease 8
emf 38


External Ids:

Disease Ontology8 DOID:12932
NCIt39 C34585
MeSH34 D004719
ICD9CM27 425.0

Related Diseases for Endomyocardial Fibrosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Clinical Features for Endomyocardial Fibrosis

About this section

Drugs & Therapeutics for Endomyocardial Fibrosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endomyocardial Fibrosis

Drug clinical trials:

Search ClinicalTrials for Endomyocardial Fibrosis

Search NIH Clinical Center for Endomyocardial Fibrosis

Search CenterWatch for Endomyocardial Fibrosis

Genetic Tests for Endomyocardial Fibrosis

About this section

Anatomical Context for Endomyocardial Fibrosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Endomyocardial Fibrosis:

32
Heart, Bone marrow, Bone, Brain, Skeletal muscle, Liver, Lung

Animal Models for Endomyocardial Fibrosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5ADRB1, CLCN1, SCXB, PDGFRA
2MP:00053698.2ADRB1, CLCN1, SCXB, PDGFRA

Publications for Endomyocardial Fibrosis

About this section
Sources:
50PubMed
See all sources

Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 419)
idTitleAuthorsYear
1
Republished: Recent advances in the epidemiology, diagnosis and treatment of endomyocardial fibrosis in Africa. (24336311)
2014
2
Massive Left Ventricular Calcification: Related to Endomyocardial Fibrosis or Idiopathic? (24365059)
2013
3
Endomyocardial Fibrosis With Massive Left Ventricular Calcification. (22483858)
2013
4
Endomyocardial fibrosis associated with mansoni schistosomiasis. (22031086)
2011
5
Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients. (21415124)
2011
6
Early presentation of endomyocardial fibrosis in a 22-month-old child: a case report. (20979685)
2011
7
Systemic thromboembolism in endomyocardial fibrosis (EMF): clinical observations, aetio-pathogenesis and treatment. (21416790)
2010
8
Endomyocardial fibrosis mimicking Ebstein's anomaly: a diagnostic challenge. (19568399)
2009
9
Endomyocardial fibrosis diagnosed by imaging. (19178035)
2008
10
Endomyocardial fibrosis: pathological and molecular findings of surgically resected ventricular endomyocardium. (18762973)
2008
11
Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and 'histamine dysmetabolism'. (18345505)
2008
12
Loeffler endomyocardial fibrosis. (16982636)
2006
13
Endomyocardial fibrosis in Mozambique. (16933583)
2006
14
Effects of ACE inhibition versus non-ACE inhibitor antihypertensive treatment on myocardial fibrosis in patients with arterial hypertension. Retrospective analysis of 120 patients with left ventricular endomyocardial biopsies. (14689110)
2003
15
Endomyocardial fibrosis is associated with selective deposition of type I collagen. (11759940)
2001
16
Idiopathic hypereosinophilic syndrome: magnetic resonance imaging findings in endomyocardial fibrosis. (11903192)
2001
17
Surgery for endomyocardial fibrosis revisited. (10333028)
1999
18
Cerium levels are elevated in the serum of patients with endomyocardial fibrosis (EMF). (9522045)
1997
19
Hypereosinophilic syndrome: endomyocardial fibrosis. (8983691)
1996
20
Endomyocardial fibrosis in Egypt: an illustrated review. (7727191)
1995
21
Endomyocardial fibrosis presenting as recurrent monomorphic ventricular tachycardia as the sole manifestation. (8112911)
1993
22
Endomyocardial fibrosis in a scuba diving death. (8228890)
1993
23
Surgical treatment of endomyocardial fibrosis: a new approach. (2229774)
1990
24
Endomyocardial fibrosis with massive endocardial calcific deposits. (3345607)
1988
25
Cardiac ultrastructure in tropical endomyocardial fibrosis. (3397162)
1988
26
The surgical treatment of endomyocardial fibrosis: results in 55 patients. (4028365)
1985
27
Are eosinophils the cause of endomyocardial fibrosis in the tropics? (2994430)
1985
28
Electron microscopic changes in tropical endomyocardial fibrosis. (6464108)
1984
29
M-mode echocardiographic features of endomyocardial fibrosis. (7104113)
1982
30
Clinical feminization and serum testosterone levels in male patients with chronic African endomyocardial fibrosis. (7167998)
1982
31
Mitral annuloplasty in endomyocardial fibrosis: an alternative to valve replacement. (7138112)
1982
32
Right ventricular endomyocardial fibrosis simulating Ebstein's anomaly. (7446389)
1980
33
LAPffler's endocarditis and endomyocardial fibrosis--a nosologic entity? (602773)
1977
34
Eosinophilia and endomyocardial fibrosis. (1258775)
1976
35
Editorial: Surgery for endomyocardial fibrosis. (59864)
1976
36
Letter: Endomyocardial fibrosis: a surgical approach. (1138649)
1975
37
Aortic embolism in endomyocardial fibrosis (EMF). (4270675)
1973
38
Endomyocardial fibrosis: clinical study of Nigerian cases. (4777906)
1973
39
Immunoglobulins and antibody to Loa loa in Nigerians with endomyocardial fibrosis and other heart diseases. (4625267)
1972
40
The diagnosis of endomyocardial fibrosis. (5086889)
1972
41
What is the spectrum of endomyocardial fibrosis? (4636093)
1972
42
The electrocardiogram in endomyocardial fibrosis. (5160381)
1971
43
Necropsy study of endomyocardial fibrosis and rheumatic heart disease in Uganda 1950-1965. (5651254)
1968
44
Evolution of endomyocardial fibrosis. (4159864)
1966
45
A CASE OF ENDOMYOCARDIAL FIBROSIS. (14335894)
1965
46
ENDOMYOCARDIAL FIBROSIS; REPORT OF 2 CASES. (14264205)
1965
47
ANGIOCARDIOGRAPHY OF ENDOMYOCARDIAL FIBROSIS. (14264023)
1965
48
DIFFUSE ENDOMYOCARDIAL FIBROSIS. (14072381)
1963
49
The electrocardiogram in endomyocardial fibrosis. (13844819)
1960
50
The pathology of endomyocardial fibrosis in Uganda. (13239929)
1955

Genetic Variations for Endomyocardial Fibrosis

About this section

Expression for genes affiliated with Endomyocardial Fibrosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

About this section
Sources:
51QIAGEN
See all sources

Pathways related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ADRB1, CLCN1, PDGFRA

Compounds for genes affiliated with Endomyocardial Fibrosis

About this section
Sources:
44Novoseek, 24HMDB
See all sources

Compounds related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium44 2410.1ADRB1, CLCN1, MBL2
2aspartate448.7PDGFRA, MBL2, ADRB1
3tyrosine448.5ADRB1, FIP1L1, MBL2, PDGFRA

GO Terms for genes affiliated with Endomyocardial Fibrosis

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:0420609.4ADRB1, PDGFRA

Products for genes affiliated with Endomyocardial Fibrosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endomyocardial Fibrosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet