MCID: END021
MIFTS: 46

Endomyocardial Fibrosis malady

Categories: Rare diseases, Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Endomyocardial Fibrosis

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Aliases & Descriptions for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 10 45 47 12 36 65
Obscure African Cardiomyopathy 10 65
Emf 40 2
African Endomyocardial Fibrosis 10
 
Becker Muscular Dystrophy 65
Endomyocardial Sclerosis 10
Becker's Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:12932
ICD9CM29 425.0
MeSH36 D004719
NCIt42 C34585
UMLS65 C0553980, C1959600, C0917713

Summaries for Endomyocardial Fibrosis

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Wikipedia:68 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards based summary: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to opisthorchiasis and placental abruption. An important gene associated with Endomyocardial Fibrosis is DMD (Dystrophin), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Hematopoietic cell lineage. Affiliated tissues include heart, bone and bone marrow, and related mouse phenotypes are liver/biliary system and respiratory system.

CDC:2 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Related Diseases for Endomyocardial Fibrosis

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Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 439)
idRelated DiseaseScoreTop Affiliating Genes
1opisthorchiasis30.1IL10, TNF
2placental abruption30.1IL10, TNF
3lateral sclerosis30.1IL10, TNF
4meningitis30.1IL10, TNF
5blepharitis30.0IL10, IL4
6hemifacial spasm29.9IL4, TNF
7achalasia29.7IL10, IL4, TNF
8malaria29.5IL10, IL4, TNF
9tropical endomyocardial fibrosis12.5
10myotonia congenita, recessive11.7
11fanconi renotubular syndrome 110.3
12leukemia10.3
13pancreatitis10.3
14endotheliitis10.3
15cycloplegia10.3IL10, IL4
16dysgammaglobulinemia10.3IL10, IL4
17dioctophymiasis10.3IL10, IL4
18penicillin allergy10.2IL10, IL4
19superficial urinary bladder cancer10.2IL10, IL4
20lung cancer10.2
21breast cancer10.2
22hepatitis10.2
23lymphoma10.2
24adenocarcinoma10.2
25influenza10.2
26buruli ulcer10.2IL10, IL4
27cow milk allergy10.2IL10, IL4
28enamel caries10.2IL10, IL4
29acalculous cholecystitis10.2IL10, IL4
30vernal conjunctivitis10.2IL10, IL4
31benign dermal neurilemmoma10.2IL10, IL4
32primary progressive multiple sclerosis10.2IL10, IL4
33hodgkin's lymphoma, nodular sclerosis10.2IL10, IL4
34gonococcal bursitis10.2IL4, TNF
35schizophrenia10.2
36neuroblastoma10.2
37colorectal cancer10.2
38corneal edema10.2
39prostatitis10.2
40retinitis10.2
41tuberculosis10.2
42adenoma10.2
43myeloid leukemia10.2
44wissler's syndrome10.2IL10, IL4
45collagenous colitis10.2IL4, TNF
46soft palate cancer10.2IL4, TNF
47hepatoid adenocarcinoma10.2IL4, TNF
48deafness, autosomal recessive 6210.2IL10, IL4
49submandibular gland disease10.2IL4, TNF
50punctate palmoplantar keratoderma type 210.2IL10, TNF

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Symptoms for Endomyocardial Fibrosis

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Drugs & Therapeutics for Endomyocardial Fibrosis

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Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 3, Phase 1206
2AntibodiesPhase 3, Phase 14477
3Immunologic FactorsPhase 3, Phase 118483
4Plasma SubstitutesPhase 3135
5ImmunoglobulinsPhase 3, Phase 14477
6Blood SubstitutesPhase 3148
7Immunoglobulins, IntravenousPhase 3, Phase 1211
8
SpironolactoneapprovedPhase 21591952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
9MineralocorticoidsPhase 2301
10Mineralocorticoid Receptor AntagonistsPhase 2284
11Natriuretic AgentsPhase 21403
12Hormone AntagonistsPhase 210002
13Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
14Diuretics, Potassium SparingPhase 21445
15diureticsPhase 21194
16HormonesPhase 211748
17Radiopharmaceuticals362
18
Iodine4947553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
19cadexomer iodine456
203-Iodobenzylguanidine60

Interventional clinical trials:

idNameStatusNCT IDPhase
1Intravenous Immunoglobulin (IVIg) for Parvovirus B19(PVB19) Mediated CardiomyopathyRecruitingNCT00892112Phase 3
2Spironolactone in Adult Congenital Heart DiseaseActive, not recruitingNCT01069510Phase 2
3IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral LoadRecruitingNCT00659386Phase 1
4The Genetic Basis of Acquired Heart Disease in AfricaRecruitingNCT02124109
5Left Atrial Volume Index in Asymptomatic Aortic StenosisRecruitingNCT02395107
6The Leiden Nonischemic Cardiomyopathy StudyRecruitingNCT01940081
7Assessment of Myocardial Fibrosis in Aortic STenosisActive, not recruitingNCT02316587
8Noninvasive Imaging of Heart Failure: A Pilot StudyActive, not recruitingNCT01160471

Search NIH Clinical Center for Endomyocardial Fibrosis


Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

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Anatomical Context for Endomyocardial Fibrosis

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MalaCards organs/tissues related to Endomyocardial Fibrosis:

33
Heart, Bone, Bone marrow, T cells, Breast, Lung, Endothelial

Animal Models for Endomyocardial Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4DMD, IL10, IL4, TNF
2MP:00053888.3DMD, IL10, IL4, TNF
3MP:00107718.3CLCN1, IL10, IL4, TNF
4MP:00053818.2DMD, IL10, IL4, TNF
5MP:00053698.2CLCN1, DMD, IL10, TNF
6MP:00053897.8CLCN1, DMD, IL10, IL4, TNF
7MP:00053917.8CLCN1, DMD, IL10, IL4, TNF
8MP:00030127.7CLCN1, DMD, IL10, IL4, TNF
9MP:00036317.6CLCN1, DMD, IL10, IL4, TNF
10MP:00053907.5CLCN1, DMD, IL10, IL4, TNF
11MP:00053787.2CLCN1, DMD, IL10, IL4, TNF

Publications for Endomyocardial Fibrosis

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Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 444)
idTitleAuthorsYear
1
MicroRNA-144 regulates proliferation, invasion, and apoptosis of cells in malignant solitary pulmonary nodule via zinc finger E-box-binding homeobox 1. (26191328)
2015
2
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. (25190313)
2014
3
Long-term outcomes of laparoscopic surgery for advanced transverse colon cancer. (24449001)
2014
4
Hemicrania continua--building on experience and clinical science. (24524422)
2014
5
Case images: Apical pouches with hypertrophic cardiomyopathy. (25362957)
2014
6
The long-term outcome predictors of pure microvascular decompression for primary trigeminal neuralgia. (22381868)
2013
7
THE VALUE OF RETINAL IMAGING WITH INFRARED SCANNING LASER OPHTHALMOSCOPY IN PATIENTS WITH STARGARDT DISEASE. (24317291)
2013
8
Autoimmune hepatitis in children: experiences in a tertiary center. (23795253)
2013
9
Effectiveness of Aloe Vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns. (23894900)
2013
10
Dyspepsia among patients with chronic kidney disease: a cross sectional study. (24139477)
2013
11
Adenovirus-expressed preS2 antibody inhibits hepatitis B virus infection and hepatic carcinogenesis. (22294841)
2012
12
Expression of interleukin-8 receptor CXCR2 and suppressor of cytokine signaling-3 in astrocytic tumors. (22231733)
2012
13
Outcome prediction of advanced mantle cell lymphoma by international prognostic index versus different mantle cell lymphoma indexes: one institution study. (22170090)
2012
14
EGFR and KRAS mutations detection on lung cancer liquid-based cytology: a pilot study. (21945923)
2012
15
Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. (20008300)
2010
16
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. (19010388)
2009
17
Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. (19602482)
2009
18
Atypical presentations of subacute sclerosing panencephalitis in two neurologically handicapped cases. (20135578)
2009
19
The carboxy-terminal domain of xeroderma pigmentosum complementation group C protein, involved in TFIIH and centrin binding, is highly disordered. (18177054)
2008
20
Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of rest. (18234667)
2008
21
Acute monoblastic leukemia in a FeLV-positive cat. (18296895)
2008
22
Identifying postpartum depression: are 3 questions as good as 10? (18762505)
2008
23
Liver dysfunction in Turner's syndrome: prevalence, natural history and effect of exogenous oestrogen. (18248644)
2008
24
Arabino-galactan proteins from Pistacia lentiscus var. chia: isolation, characterization and biological function. (17514491)
2008
25
Juvenile polyposis syndrome. (20011494)
2008
26
Dermoscopy of lichen planus-like keratosis: a model of inflammatory regression. (17958847)
2007
27
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. (16839844)
2006
28
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. (15998797)
2005
29
Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization. (15961404)
2005
30
Acute respiratory failure due to Mycobacterium kansasii infection: immune reconstitution disease in a patient with AIDS. (16291290)
2005
31
Predictors of outcome in patients with severe aortic stenosis and normal left ventricular function: role of B-type natriuretic peptide. (15541842)
2004
32
Comparison of L-selectin and CD11b on neutrophils of adults and neonates during the first month of life. (12508092)
2003
33
Quinolinic acid in the pathogenesis of Alzheimer's disease. (15206729)
2003
34
Estimating the stenosis probabilities in arteriosclerosis obliterans using generalized estimating equations. (12820280)
2003
35
Proteolyzed matrix as a template for the regulation of tumor progression. (12888258)
2003
36
Theoretical studies on the mechanism of inhibition of Ribonucleotide Reductase by (E)-2'-Fluoromethylene-2'-deoxycitidine-5'-diphosphate. (12785865)
2003
37
Familial mutation in the testis-determining gene SRY shared by an XY female and her normal father. (12107262)
2002
38
Advances in diabetic gastroparesis. (12122960)
2002
39
Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. (9806735)
1998
40
Plasmodium vivax malaria acquired in far north Queensland. (9033563)
1997
41
Picture of the month. Paraphimosis. (9080944)
1997
42
No evidence for genomic imprinting of the human BCR gene. (8204871)
1994
43
Coexistence of cervical and lumbar disc disease. (2281370)
1990
44
Identification of 4,6-dioxoheptanoic acid (succinylacetone), 3,5-dioxooctanedioic acid (succinylacetoacetate) and 4-Oxo-6-hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia. (7171740)
1982
45
A possibility of predicting metastatic ability of tumours by implantation into chick embryos. Epigenetic grading of metastasizing and non-metastasizing forms of a hamster lymphosarcoma. (6893184)
1980
46
Bronchopulmonary geotrichosis. (4796160)
1973
47
Studies on the pathogenesis of lipoatrophic diabetes: a case of congenital systemic absence of adipose tissue associated with insulin-resistant diabetes mellitus and hepatosplenomegaly. (4641790)
1972
48
Value of preoperative electrodiagnosis in assessment of locomotor function of lower limbs in spina bifida cystica. (4897094)
1968
49
Glossitis Migrans. (19984958)
1926
50

Variations for Endomyocardial Fibrosis

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Clinvar genetic disease variations for Endomyocardial Fibrosis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DMDNM_004006.2(DMD): c.9G> A (p.Trp3Ter)single nucleotide variantPathogenicrs398122853GRCh37Chr X, 33229421: 33229421
2DMDNM_004006.2(DMD): c.10171C> T (p.Arg3391Ter)single nucleotide variantPathogenicrs398123832GRCh37Chr X, 31196838: 31196838
3DMDNM_004006.2(DMD): c.31+1G> Tsingle nucleotide variantPathogenicrs398123923GRCh37Chr X, 33229398: 33229398

Expression for genes affiliated with Endomyocardial Fibrosis

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Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

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Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3IL4, TNF
29.3IL4, TNF
39.1IL10, TNF
49.1IL10, TNF
59.1IL10, TNF
69.1IL10, TNF
79.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
99.0IL10, IL4
109.0IL10, IL4
119.0IL10, IL4
128.5IL10, IL4, TNF
138.5IL10, IL4, TNF
148.5IL10, IL4, TNF
15
Show member pathways
8.5IL10, IL4, TNF
168.5IL10, IL4, TNF
17
Show member pathways
8.5IL10, IL4, TNF
18
Show member pathways
8.5IL10, IL4, TNF
19
Show member pathways
8.1DMD, IL10, IL4, TNF

GO Terms for genes affiliated with Endomyocardial Fibrosis

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Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mononuclear cell migrationGO:007167710.0IL4, TNF
2positive regulation of chemokine biosynthetic processGO:00450809.9IL4, TNF
3receptor biosynthetic processGO:00328009.8IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
5negative regulation of growth of symbiont in hostGO:00441309.6IL10, TNF
6defense response to protozoanGO:00428329.6IL10, IL4
7negative regulation of interleukin-6 productionGO:00327159.6IL10, TNF
8type 2 immune responseGO:00420929.6IL10, IL4
9response to glucocorticoidGO:00513849.6IL10, TNF
10B cell differentiationGO:00301839.6IL10, IL4
11negative regulation of endothelial cell apoptotic processGO:20003529.5IL10, IL4
12positive regulation of protein phosphorylationGO:00019349.4IL4, TNF
13negative regulation of nitric oxide biosynthetic processGO:00450199.4IL10, IL4
14positive regulation of MHC class II biosynthetic processGO:00453489.4IL10, IL4
15response to organic substanceGO:00100339.1IL10, TNF
16defense response to bacteriumGO:00427429.0IL10, TNF
17positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL10, IL4, TNF
18positive regulation of transcription, DNA-templatedGO:00458938.8IL10, IL4, TNF
19immune responseGO:00069558.5IL10, IL4, TNF

Sources for Endomyocardial Fibrosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet