EMF
MCID: END021
MIFTS: 47

Endomyocardial Fibrosis (EMF) malady

Rare diseases, Cardiovascular diseases, Muscle diseases categories
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Summaries for Endomyocardial Fibrosis

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Wikipedia:65 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards based summary: Endomyocardial Fibrosis, also known as african endomyocardial fibrosis, is related to hypereosinophilic syndrome and eosinophilia. An important gene associated with Endomyocardial Fibrosis is CLCN1 (chloride channel, voltage-sensitive 1), and among its related pathways are NFAT and Cardiac Hypertrophy and Endocytosis. The compounds valine and sodium have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skeletal muscle, and related mouse phenotypes are no phenotypic analysis and skeleton.

CDC:3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Aliases & Classifications for Endomyocardial Fibrosis

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Endomyocardial Fibrosis, Aliases & Descriptions:

Name: Endomyocardial Fibrosis 8 42 10 44 62
African Endomyocardial Fibrosis 8 62
Obscure African Cardiomyopathy 8 62
Endomyocardial Sclerosis 8 62
 
Becker Generalized Myotonia 62
Becker's Disease 8
Emf 38


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Muscle diseases


External Ids:

Disease Ontology8 DOID:12932
ICD9CM27 425.0
NCIt39 C34585
MeSH34 D004719

Related Diseases for Endomyocardial Fibrosis

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Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Symptoms for Endomyocardial Fibrosis

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Drugs & Therapeutics for Endomyocardial Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Endomyocardial Fibrosis

Search NIH Clinical Center for Endomyocardial Fibrosis

Genetic Tests for Endomyocardial Fibrosis

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Anatomical Context for Endomyocardial Fibrosis

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MalaCards organs/tissues related to Endomyocardial Fibrosis:

32
Heart, Brain, Skeletal muscle, Liver, Lung

Animal Models for Endomyocardial Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.0CLCN1, ADRB1, PDGFRA
2MP:00053909.0CLCN1, ADRB1, PDGFRA
3MP:00053698.7PDGFRA, ADRB1, CLCN1
4MP:00053768.3CLCN1, ADRB1, PDGFRA, MBL2

Publications for Endomyocardial Fibrosis

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Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 421)
idTitleAuthorsYear
1
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
2
Usefulness of cardiac MRI in the early diagnosis of endomyocardial fibrosis. (22503434)
2012
3
Systemic thromboembolism in endomyocardial fibrosis (EMF): clinical observations, aetio-pathogenesis and treatment. (21416790)
2010
4
Searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry. (19823676)
2009
5
Endomyocardial fibrosis mimicking Ebstein's anomaly: a diagnostic challenge. (19568399)
2009
6
Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis: myocardial disease. (18276824)
2008
7
Typical clinical aspect of endomyocardial fibrosis. (16257072)
2006
8
Pitfalls in diagnosis and clinical, echocardiographic, and hemodynamic findings in endomyocardial fibrosis: a 25-year experience. (16354870)
2005
9
Multiple microembolic borderzone brain infarctions and endomyocardial fibrosis in idiopathic hypereosinophilic syndrome and in Schistosoma mansoni infestation. (14742613)
2004
10
Endomyocardial fibrosis (Davies disease) coincidental with systemic lupus erythematosus. (10855412)
2000
11
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. (9588233)
1998
12
Endomyocardial fibrosis in Zimbabwe--how rare is it? A report of two cases. (8997819)
1996
13
Right-sided endomyocardial fibrosis with recurrent pulmonary emboli leading to irreversible pulmonary hypertension. (1389768)
1992
14
Echocardiographic findings in endomyocardial fibrosis. (1509530)
1992
15
A geochemical basis for endomyocardial fibrosis. (2598218)
1989
16
Effectiveness of operative and nonoperative therapy in endomyocardial fibrosis. (2711999)
1989
17
Surgical treatment of endomyocardial fibrosis. (3800484)
1987
18
Unusual echocardiographic appearance of intracardiac thrombi in a patient with endomyocardial fibrosis. (3730220)
1986
19
Postoperative evaluation of endomyocardial fibrosis. (3955583)
1986
20
Serum immunoglobulins in patients with endomyocardial fibrosis. (3447948)
1986
21
Increase in extracellular matrix components & absence of eosinophil granule protein in heart tissue affected with endomyocardial fibrosis. (3759173)
1986
22
Immunohistological studies in endomyocardial fibrosis. (6373573)
1984
23
Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy. (6736450)
1984
24
Phonomechanocardiographic findings in endomyocardial fibrosis. (6696288)
1984
25
Endomyocardial fibrosis in Thai children. (6491562)
1984
26
Surgical palliation for endomyocardial fibrosis. (6695359)
1984
27
Endomyocardial fibrosis with successful surgical treatment in a Hungarian woman. (6617211)
1983
28
Technical aspects in surgery for endomyocardial fibrosis: experience with 37 patients. (15227123)
1983
29
Coronary angiographic features in endomyocardial fibrosis. (6193879)
1983
30
Endomyocardial fibrosis masquerading as rheumatic mitral incompetence. A report of six surgical cases. (6632949)
1983
31
M-mode echocardiographic features of endomyocardial fibrosis. (7104113)
1982
32
Echocardiographic findings in endomyocardial fibrosis. (7083941)
1982
33
Relation of severe eosinophilia and microfilariasis to chronic African endomyocardial fibrosis. (7259917)
1981
34
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
35
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. (869976)
1977
36
Endomyocardial fibrosis and eosinophilia. (849383)
1977
37
Eosinophilia and endomyocardial fibrosis. (1258775)
1976
38
Endomyocardial fibrosis. Problems in differential diagnosis. (131566)
1976
39
E.C.G. in endomyocardial fibrosis. (4425511)
1974
40
Morphogenesis of endomyocardial fibrosis. (4544107)
1973
41
Immunoglobulins and antibody to Loa loa in Nigerians with endomyocardial fibrosis and other heart diseases. (4625267)
1972
42
The electrocardiogram in endomyocardial fibrosis. (5160381)
1971
43
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968
44
Endomyocardial fibrosis in a North American Negro. Probable familial incidence. (4175550)
1968
45
Necropsy study of endomyocardial fibrosis and rheumatic heart disease in Uganda 1950-1965. (5651254)
1968
46
Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics. (4163977)
1967
47
Endomyocardial fibrosis in Uganda (Davies' disease). 1. An epidemiologic, clinical, and pathologic study. (4861733)
1967
48
ADULT ENDOMYOCARDIAL FIBROSIS IN BRITAIN. (14044273)
1963
49
The evolution of endomyocardial fibrosis. (14480770)
1962
50
Intracardiac calcification in endomyocardial fibrosis. (13915097)
1962

Variations for Endomyocardial Fibrosis

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Expression for genes affiliated with Endomyocardial Fibrosis

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Expression patterns in normal tissues for genes affiliated with Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

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Pathways related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4ADRB1, PDGFRA
29.4ADRB1, PDGFRA
39.4PDGFRA, ADRB1
4
Show member pathways
9.4ADRB1, PDGFRA
5
Show member pathways
9.0PDGFRA, ADRB1, CLCN1

Compounds for genes affiliated with Endomyocardial Fibrosis

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Sources:
44Novoseek, 24HMDB, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1valine449.3MBL2, ADRB1
2sodium44 249.9ADRB1, CLCN1, MBL2
3imatinib44 50 1110.8PDGFRA, FIP1L1
4aspartate448.7MBL2, ADRB1, PDGFRA
5tyrosine448.0MBL2, ADRB1, FIP1L1, PDGFRA

GO Terms for genes affiliated with Endomyocardial Fibrosis

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Cellular components related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.0PDGFRA, ADRB1, CLCN1

Biological processes related to Endomyocardial Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:0420609.4PDGFRA, ADRB1

Products for genes affiliated with Endomyocardial Fibrosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Endomyocardial Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet