MCID: END021
MIFTS: 42

Endomyocardial Fibrosis malady

Rare diseases, Cardiovascular diseases, Muscle diseases categories

Aliases & Classifications for Endomyocardial Fibrosis

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Endomyocardial Fibrosis, Aliases & Descriptions:

Name: Endomyocardial Fibrosis 9 41 11 43 60
Obscure African Cardiomyopathy 9 60
Emf 37 3
African Endomyocardial Fibrosis 9
 
Becker Muscular Dystrophy 60
Endomyocardial Sclerosis 9
Becker's Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Muscle diseases


External Ids:

Disease Ontology9 DOID:12932
MeSH33 D004719
NCIt38 C34585
ICD9CM27 425.0

Summaries for Endomyocardial Fibrosis

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Wikipedia:63 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

MalaCards based summary: Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to hypereosinophilic syndrome and eosinophilia. An important gene associated with Endomyocardial Fibrosis is DMD (dystrophin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Endocytosis. The compounds prednisolone and chloride have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skeletal muscle, and related mouse phenotypes are no phenotypic analysis and muscle.

CDC:3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

Related Diseases for Endomyocardial Fibrosis

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Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to endomyocardial fibrosis

Symptoms for Endomyocardial Fibrosis

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Drugs & Therapeutics for Endomyocardial Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Endomyocardial Fibrosis

Search NIH Clinical Center for Endomyocardial Fibrosis

Genetic Tests for Endomyocardial Fibrosis

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Anatomical Context for Endomyocardial Fibrosis

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MalaCards organs/tissues related to Endomyocardial Fibrosis:

31
Heart, Brain, Skeletal muscle, Liver, Lung

Animal Models for Endomyocardial Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7DMD, CLCN1, ADRB1, PDGFRA
2MP:00053698.6PDGFRA, ADRB1, CLCN1, DMD
3MP:00053678.6PDGFRA, DMD, MBL2
4MP:00053788.6PDGFRA, ADRB1, CLCN1, DMD
5MP:00053908.5ADRB1, CLCN1, DMD, PDGFRA
6MP:00053767.9DMD, CLCN1, ADRB1, PDGFRA, MBL2

Publications for Endomyocardial Fibrosis

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Articles related to Endomyocardial Fibrosis:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
Restrictive cardiomyopathy as a result of endomyocardial fibrosis from hypereosinophilia. (25582942)
2015
2
Predominant RV endomyocardial fibrosis masking rheumatic mitral stenosis. (25438498)
2014
3
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
4
Usefulness of cardiac MRI in the early diagnosis of endomyocardial fibrosis. (22503434)
2012
5
Systemic thromboembolism in endomyocardial fibrosis (EMF): clinical observations, aetio-pathogenesis and treatment. (21416790)
2010
6
Searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry. (19823676)
2009
7
Endomyocardial fibrosis mimicking Ebstein's anomaly: a diagnostic challenge. (19568399)
2009
8
Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis: myocardial disease. (18276824)
2008
9
Typical clinical aspect of endomyocardial fibrosis. (16257072)
2006
10
Pitfalls in diagnosis and clinical, echocardiographic, and hemodynamic findings in endomyocardial fibrosis: a 25-year experience. (16354870)
2005
11
Multiple microembolic borderzone brain infarctions and endomyocardial fibrosis in idiopathic hypereosinophilic syndrome and in Schistosoma mansoni infestation. (14742613)
2004
12
Endomyocardial fibrosis of right ventricle. (11163568)
2001
13
Endomyocardial fibrosis (Davies disease) coincidental with systemic lupus erythematosus. (10855412)
2000
14
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. (9588233)
1998
15
Endomyocardial fibrosis in Zimbabwe--how rare is it? A report of two cases. (8997819)
1996
16
Right-sided endomyocardial fibrosis with recurrent pulmonary emboli leading to irreversible pulmonary hypertension. (1389768)
1992
17
Echocardiographic findings in endomyocardial fibrosis. (1509530)
1992
18
A geochemical basis for endomyocardial fibrosis. (2598218)
1989
19
Effectiveness of operative and nonoperative therapy in endomyocardial fibrosis. (2711999)
1989
20
Surgical treatment of endomyocardial fibrosis. (3800484)
1987
21
Unusual echocardiographic appearance of intracardiac thrombi in a patient with endomyocardial fibrosis. (3730220)
1986
22
Postoperative evaluation of endomyocardial fibrosis. (3955583)
1986
23
Serum immunoglobulins in patients with endomyocardial fibrosis. (3447948)
1986
24
Immunohistological studies in endomyocardial fibrosis. (6373573)
1984
25
Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy. (6736450)
1984
26
Phonomechanocardiographic findings in endomyocardial fibrosis. (6696288)
1984
27
Endomyocardial fibrosis in Thai children. (6491562)
1984
28
Surgical palliation for endomyocardial fibrosis. (6695359)
1984
29
Endomyocardial fibrosis with successful surgical treatment in a Hungarian woman. (6617211)
1983
30
Technical aspects in surgery for endomyocardial fibrosis: experience with 37 patients. (15227123)
1983
31
Coronary angiographic features in endomyocardial fibrosis. (6193879)
1983
32
M-mode echocardiographic features of endomyocardial fibrosis. (7104113)
1982
33
Echocardiographic findings in endomyocardial fibrosis. (7083941)
1982
34
Relation of severe eosinophilia and microfilariasis to chronic African endomyocardial fibrosis. (7259917)
1981
35
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
36
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. (869976)
1977
37
Endomyocardial fibrosis and eosinophilia. (849383)
1977
38
Eosinophilia and endomyocardial fibrosis. (1258775)
1976
39
Endomyocardial fibrosis. Problems in differential diagnosis. (131566)
1976
40
E.C.G. in endomyocardial fibrosis. (4425511)
1974
41
Morphogenesis of endomyocardial fibrosis. (4544107)
1973
42
Immunoglobulins and antibody to Loa loa in Nigerians with endomyocardial fibrosis and other heart diseases. (4625267)
1972
43
The electrocardiogram in endomyocardial fibrosis. (5160381)
1971
44
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968
45
Endomyocardial fibrosis in a North American Negro. Probable familial incidence. (4175550)
1968
46
Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics. (4163977)
1967
47
Endomyocardial fibrosis in Uganda (Davies' disease). 1. An epidemiologic, clinical, and pathologic study. (4861733)
1967
48
ADULT ENDOMYOCARDIAL FIBROSIS IN BRITAIN. (14044273)
1963
49
The evolution of endomyocardial fibrosis. (14480770)
1962
50
Intracardiac calcification in endomyocardial fibrosis. (13915097)
1962

Variations for Endomyocardial Fibrosis

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Clinvar genetic disease variations for Endomyocardial Fibrosis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1DMDNM_004006.2(DMD): c.503C> A (p.Ala168Asp)single nucleotide variantPathogenicrs128626236GRCh37Chr X, 32834612: 32834612
2DMDNM_004006.2(DMD): c.691T> A (p.Tyr231Asn)single nucleotide variantPathogenicrs128626237GRCh37Chr X, 32717369: 32717369
3DMDNM_004006.2(DMD): c.10262C> T (p.Ala3421Val)single nucleotide variantPathogenicrs104894791GRCh37Chr X, 31196049: 31196049
4DMDNM_004006.2(DMD): c.3631G> T (p.Glu1211Ter)single nucleotide variantPathogenicrs267606771GRCh37Chr X, 32466728: 32466728
5DMDNM_004006.2(DMD): c.3940C> T (p.Arg1314Ter)single nucleotide variantPathogenicrs5030730GRCh37Chr X, 32456489: 32456489

Expression for genes affiliated with Endomyocardial Fibrosis

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Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for genes affiliated with Endomyocardial Fibrosis

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Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.5ADRB1, DMD
29.4ADRB1, PDGFRA
39.4PDGFRA, ADRB1
4
Show member pathways
9.4ADRB1, PDGFRA
5
Show member pathways
9.0PDGFRA, ADRB1, CLCN1

Compounds for genes affiliated with Endomyocardial Fibrosis

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Sources:
43Novoseek, 28IUPHAR, 12DrugBank, 49PharmGKB, 24HMDB
See all sources

Compounds related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1prednisolone43 28 1211.6MBL2, DMD
2chloride439.6CLCN1, DMD
3agarose439.6MBL2, DMD
4isoproterenol43 1210.5DMD, ADRB1
5imatinib43 49 1211.2PDGFRA, FIP1L1
6nitric oxide43 24 1211.1DMD, ADRB1, MBL2
7aspartate439.0MBL2, PDGFRA, ADRB1
8valine439.0MBL2, ADRB1
9atp43 2810.0PDGFRA, DMD, MBL2
10glucose438.8ADRB1, DMD, MBL2
11sodium43 249.7MBL2, ADRB1, CLCN1, DMD
12calcium43 49 24 1211.6DMD, ADRB1, PDGFRA, MBL2
13tyrosine437.8DMD, ADRB1, FIP1L1, PDGFRA, MBL2

GO Terms for genes affiliated with Endomyocardial Fibrosis

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Cellular components related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:00423839.3CLCN1, DMD
2integral component of plasma membraneGO:00058879.0PDGFRA, ADRB1, CLCN1

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:00420609.4PDGFRA, ADRB1

Products for genes affiliated with Endomyocardial Fibrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Endomyocardial Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet