MCID: END047
MIFTS: 60

Endophthalmitis malady

Eye diseases, Rare diseases categories
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Summaries for Endophthalmitis

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Wikipedia:65 Endophthalmitis is an inflammation of the internal coats of the eye. It is a possible complication of... more...

MalaCards based summary: Endophthalmitis is related to retinal vasculitis and meningitis. An important gene associated with Endophthalmitis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are IL12 signaling mediated by STAT4 and Immune response IL 12 signaling pathway. The compounds cilomilast and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and endothelial, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Disease Ontology:8 A globe disease that is characterized by inflammation of the inside of the eye.

Aliases & Classifications for Endophthalmitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Endophthalmitis, Aliases & Descriptions:

Name: Endophthalmitis 8 10 44 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 48 
Rare eye diseases


External Ids:

Disease Ontology8 DOID:4692
NCIt39 C34586
MeSH34 D009877
UMLS via Orphanet63 C0014236
MESH via Orphanet35 D009877
ICD10 via Orphanet26 H44.0, H44.1
ICD1025 H45.1

Related Diseases for Endophthalmitis

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Diseases in the Endophthalmitis family:

Acute Endophthalmitis Chronic Endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis31.1SAG
2meningitis31.0LACTB, PRF1, IL8
3endocarditis30.9LACTB, PRF1
4prostatitis30.7LACTB
5bacterial meningitis30.6IL8, LACTB
6central retinal artery occlusion30.5PLAT
7uveitis30.5IFNG, SAG, TNF
8aspergillosis30.5ELANE, IFNG
9retinal detachment30.5VEGFA, PLAT
10candidiasis30.5IFNG
11vasculitis30.4ELANE, SAG, TNF
12neutropenia30.2LACTB, ELANE, CSF2
13bronchiectasis30.2ELANE, IL8
14disseminated intravascular coagulation30.1ELANE, PLAT, F5
15arthritis29.9TNF, IL8
16pneumonia29.8DEFB1, TNF, LACTB, PRF1, ELANE, IL8
17age related macular degeneration29.7PLAT, VEGFA
18graft versus host disease29.7CSF2, IFNG, TNF
19leukemia29.5TNF, LACTB, IFNG, CSF2, HMGB1
20tuberculosis29.4TNF, LACTB, SAG, PRF1, IFNG
21sepsis29.0DEFB1, TNF, LACTB, ELANE, IL8, CSF2
22cataract10.9
23acute endophthalmitis10.7
24chronic endophthalmitis10.6
25eales disease10.6SAG
26klebsiella10.6
27pustulosis palmaris et plantaris10.5ELANE
28arthus reaction10.5ELANE
29tonsillitis10.5LACTB
30felty's syndrome10.5CSF2
31pharyngitis10.5LACTB
32branch retinal artery occlusion10.5F5
33retinal vascular occlusion10.5F5
34retinitis10.5
35cardiac rupture10.5PLAT
36periodontitis10.5IL8
37coronary thrombosis10.4PLAT
38endotheliitis10.4
39sinusitis10.4LACTB
40keratitis10.4
41retinopathy of prematurity10.4VEGFA
42stomatitis10.4CSF2
43aplastic anemia10.4IFNG
44cellulitis10.4
45capillary leak syndrome10.4CSF2, ELANE
46orbital cellulitis10.4
47severe congenital neutropenia autosomal recessive 310.4ELANE, CSF2
48cyclic hematopoiesis10.4ELANE, CSF2
49severe congenital neutropenia10.4ELANE, CSF2
50sympathetic ophthalmia10.4

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to endophthalmitis

Symptoms for Endophthalmitis

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Drugs & Therapeutics for Endophthalmitis

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Drug clinical trials:

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Search NIH Clinical Center for Endophthalmitis

Genetic Tests for Endophthalmitis

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Anatomical Context for Endophthalmitis

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MalaCards organs/tissues related to Endophthalmitis:

32
Eye, Liver, Endothelial, Lung, Retina, Testes, Brain, Cortex, Prostate, Pituitary

Animal Models for Endophthalmitis or affiliated genes

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MGI Mouse Phenotypes related to Endophthalmitis:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2PLAT, IFNG, CCNE1, TNF, VEGFA
2MP:00053798.2VEGFA, TNF, PRF1, CCNE1, IFNG, CSF2
3MP:00053828.1VEGFA, TNF, IFNG, PLAT, CSF2
4MP:00020068.1VEGFA, TNF, PRF1, ELANE, CCNE1, IFNG
5MP:00053708.0VEGFA, TNF, PRF1, IFNG, F5
6MP:00107718.0VEGFA, TNF, PRF1, CCNE1, IFNG, CSF2
7MP:00053908.0VEGFA, TNF, CCNE1, IFNG, PLAT, CSF2
8MP:00053807.9VEGFA, TNF, CCNE1, IFNG, CSF2, F5
9MP:00053897.9VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
10MP:00053917.9VEGFA, TNF, SAG, IFNG, PLAT, HMGB1
11MP:00053887.9VEGFA, TNF, IFNG, PLAT, CSF2, HMGB1
12MP:00053857.7VEGFA, TNF, CCNE1, IFNG, PLAT, CSF2
13MP:00036317.6VEGFA, TNF, SAG, PRF1, CCNE1, IFNG
14MP:00053847.4VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
15MP:00053977.3VEGFA, TNF, PRF1, ELANE, CCNE1, IFNG
16MP:00053867.1VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
17MP:00053787.1VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
18MP:00053767.0VEGFA, TNF, PRF1, ELANE, IFNG, PLAT
19MP:00053877.0CSF2, DEFB1, VEGFA, TNF, PRF1, ELANE
20MP:00107686.5DEFB1, VEGFA, TNF, PRF1, ELANE, CCNE1

Publications for Endophthalmitis

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Articles related to Endophthalmitis:

(show top 50)    (show all 686)
idTitleAuthorsYear
1
Concurrent Endophthalmitis and Orbital Cellulitis From Metastatic Klebsiella pneumonia Liver Abscess. (25186218)
2014
2
A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors. (24420916)
2014
3
Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis. (24613894)
2014
4
Late surgical complications to endophthalmitis after cataract surgery in the post-EVS era. (25315849)
2014
5
A case of endogenous endophthalmitis complicated by neutropenia following bacteremia with Streptococcus mitis resistant to beta-lactam antibiotics. (22830590)
2013
6
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
7
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. (23857416)
2013
8
Risk factors for acute endophthalmitis following cataract surgery: a systematic review and meta-analysis. (23990980)
2013
9
NO CASES OF ENDOPHTHALMITIS AFTER 20,293 INTRAVITREAL INJECTIONS IN AN OPERATING ROOM SETTING. (24317292)
2013
10
ENDOPHTHALMITIS CAUSED BY ACHROMOBACTER XYLOSOXIDANS AFTER CATARACT SURGERY. (24150240)
2013
11
Endophthalmitis following intravitreal anti-VEGF injections in ambulatory surgical centre facility: incidence, management and outcome. (24064940)
2013
12
Endophthalmitis: an unusual presentation of bacteremia. (23262812)
2013
13
Incidence of acute endophthalmitis after intravitreal bevacizumab injection in a single clinical center. (23400076)
2013
14
Factors determining visual outcome in endogenous Candida endophthalmitis. (22298012)
2012
15
Endophthalmitis is not a "never event". (22858024)
2012
16
Diagnostic dilemmas in retinitis and endophthalmitis. (22116459)
2012
17
Real-time polymerase chain reaction in the diagnosis of acute postoperative endophthalmitis. (23149369)
2012
18
Use of DNA microarray analysis in diagnosis of bacterial and fungal endophthalmitis. (22399844)
2012
19
Recurrent endophthalmitis after trabeculectomy for glaucoma: importance of timely filtering bleb coverage for the conjunctiva. (23185177)
2012
20
Delayed- versus acute-onset endophthalmitis after cataract surgery. (22813452)
2012
21
Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA. (22527320)
2012
22
Surveillance of late-onset bleb leak, blebitis and bleb-related endophthalmitis--a UK incidence study. (22249317)
2012
23
Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes. (22709846)
2012
24
The comparison of fluoroquinolones to nonfluoroquinolone antibacterial agents for the prevention of endophthalmitis in a rabbit model. (22925112)
2012
25
Intravitreal daptomycin in a case of bilateral endogenous endophthalmitis. (22776941)
2012
26
Prophylactic effect of topical fluoroquinolones in a rabbit model of Staphylococcus aureus endophthalmitis. (22077488)
2012
27
Infectious keratitis progressing to endophthalmitis: a 15-year study of microbiology, associated factors, and clinical outcomes. (22858123)
2012
28
Endogenous Candida albicans endophthalmitis following spontaneous abortion and IUD removal. (22165949)
2011
29
Self-induced Elizabethkingia meningoseptica endophthalmitis: a case report. (21745367)
2011
30
Severe acute endogenous endophthalmitis with Staphylococcus epidermidis in a systemically well patient. (23861621)
2011
31
Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. (21705087)
2011
32
Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis. (21358364)
2011
33
Clinical review of endogenous endophthalmitis in Korea: a 14-year review of culture positive cases of two large hospitals. (21623606)
2011
34
Late-onset Citrobacter koseri endophthalmitis with suture exposure after secondary intraocular lens implantation. (21860579)
2011
35
Preventive scleral buckling and silicone oil tamponade are important for posttraumatic endophthalmitis successfully managed with vitrectomy. (21893970)
2011
36
Obviating endophthalmitis after cataract surgery: excellent wound closure is the key. (22084227)
2011
37
A cluster of acute-onset postoperative endophthalmitis over a 1-month period: investigation of an outbreak caused by uncommon species. (20733020)
2011
38
Acute postoperative endophthalmitis in a patient with Darier's disease. (20806743)
2010
39
A case of bilateral endogenous Pantoea agglomerans endophthalmitis with interstitial lung disease. (20714391)
2010
40
Case of endogenous endophthalmitis caused by Streptococcus equisimilis. (20823933)
2010
41
Re: Infectious endophthalmitis after intravitreal injection of antiangiogenic agents. (21060278)
2010
42
Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. (20370345)
2010
43
Postoperative mycotic endophthalmitis. (20610105)
2010
44
Bilateral endophthalmitis as the initial presentation of bacterial meningitis. (20046699)
2009
45
Actinomyces neuii subspecies anitratus chronic endophthalmitis after cataract surgery. (17534833)
2007
46
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
47
Risk factors of acute endophthalmitis after cataract extraction: a case-control study in Asian eyes. (14693767)
2004
48
Pink hypopyon: a sign of Serratia marcescens endophthalmitis. (1486086)
1992
49
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (6985228)
1982
50
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (206999)
1977

Variations for Endophthalmitis

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Expression for genes affiliated with Endophthalmitis

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Expression patterns in normal tissues for genes affiliated with Endophthalmitis

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Pathways for genes affiliated with Endophthalmitis

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Pathways related to Endophthalmitis according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, PRF1
29.8IFNG, PRF1
39.7CSF2, IL8
4
Show member pathways
9.7PRF1, HMGB1
59.5TNF, IL8
69.5IFNG, TNF
7
Show member pathways
9.4CCNE1, PRF1, TNF
89.4IFNG, VEGFA
9
Show member pathways
9.3CSF2, IL8, IFNG
109.3IFNG, IL8, CSF2
11
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.3IFNG, PRF1, TNF
12
Show member pathways
9.3TNF, PRF1, IFNG
139.2PLAT, IL8, IFNG
14
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.2CSF2, IFNG, TNF
159.2CSF2, IFNG, TNF
16
Show member pathways
9.2CSF2, IFNG, TNF
17
Show member pathways
Signaling Pathways in Glioblastoma37
9.2VEGFA, CCNE1, IL8
18
Show member pathways
thioredoxin pathway37
9.1TNF, IFNG, PLAT
199.1TNF, IFNG, IL8
20
Show member pathways
Immune response MIF in innate immunity response60
9.1IL8, IFNG, TNF
219.1TNF, IFNG, IL8
229.1IL8, IFNG, TNF
239.1TNF, IFNG, IL8
24
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IL8, IFNG, TNF
259.1ELANE, IL8, PLAT, CSF2
269.1CCNE1, TNF, VEGFA
27
Show member pathways
9.0TNF, IL8, HMGB1
28
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.0VEGFA, TNF, CSF2
29
Show member pathways
Immune response CD16 signaling in NK cells60
8.9CSF2, IFNG, PRF1, TNF
308.9IL8, TNF, VEGFA
31
Show member pathways
8.8IL8, IFNG, CCNE1, TNF
32
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8TNF, CCNE1, IFNG, IL8
338.8TNF, IFNG, IL8, CSF2
34
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.8CSF2, IL8, IFNG, TNF
358.8TNF, ELANE, PLAT, HMGB1
36
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.7TNF, CCNE1, IFNG, HMGB1
378.1CSF2, IL8, IFNG, TNF, VEGFA
38
Show member pathways
8.1CSF2, IL8, IFNG, TNF, VEGFA

Compounds for genes affiliated with Endophthalmitis

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Compounds related to Endophthalmitis according to GeneCards/GeneDecks:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1cilomilast449.5TNF, IL8, ELANE
2ulinastatin449.5IL8, ELANE, TNF
3protamine449.4ELANE, PLAT, F5, IL8
4mip 1alpha449.3CSF2, IL8, TNF
5anaphylatoxin449.3HMGB1, CSF2, ELANE, IL8
6vancomycin44 1110.3LACTB, ELANE, F5
7aprotinin44 1110.2IL8, F5, PLAT, ELANE
8n-formylmethionyl-leucylphenylalanine449.2TNF, CSF2, IL8, ELANE
9ivig449.2CSF2, TNF, SAG, IFNG
10polymyxin b449.2TNF, DEFB1, IL8, IFNG
11il-12449.2IL8, CSF2, IFNG, TNF
12imiquimod44 61 28 1112.2TNF, IFNG, IL8, CSF2
13ceftriaxone44 1110.2PLAT, LACTB, F5
14taurine chloramine449.2IL8, F5, TNF, IFNG
15rolipram44 61 2811.2ELANE, TNF, IL8, IFNG
16budesonide44 50 1111.2IL8, CSF2, IFNG, TNF
17poly(i-c)449.1CSF2, IL8, IFNG, TNF
18il 10449.1TNF, IL8, IFNG, CSF2
19tarc449.1TNF, IFNG, IL8, CSF2
20azithromycin44 1110.1LACTB, CSF2, IL8
21gold sodium thiomalate449.0IL8, TNF, IFNG
22ofloxacin44 2 1111.0F5, CSF2, LACTB
23gabexate mesilate449.0TNF, ELANE, IL8, PLAT, F5
24fluticasone propionate44 50 61 1111.9TNF, ELANE, IFNG, IL8, CSF2
25pentoxifylline44 119.9ELANE, CSF2, IL8, IFNG, TNF
26neopterin448.9TNF, CSF2, IL8, IFNG, ELANE
27triptolide448.9TNF, VEGFA, IFNG, IL8
28rantes448.8DEFB1, IFNG, IL8, CSF2, TNF
29prostacyclin448.7TNF, VEGFA, F5, PLAT, ELANE
30thalidomide44 50 61 1111.6CSF2, IFNG, VEGFA, TNF
3115-deoxy-delta-12,14-prostaglandin j2448.6TNF, VEGFA, IL8, IFNG, CSF2
32hydrocortisone44 2 61 1111.6F5, IL8, IFNG, ELANE, CSF2, TNF
33carboplatin44 50 1110.6HMGB1, IFNG, VEGFA, CSF2
34superoxide44 249.5TNF, HMGB1, CSF2, ELANE, PRF1, IL8
35butyrate448.4HMGB1, CSF2, IL8, TNF, IFNG
36lactate448.4HMGB1, CSF2, TNF, IL8, ELANE, F5
37gm-csf44 289.3TNF, IFNG, ELANE, VEGFA, IL8, CSF2
38simvastatin44 50 61 28 24 1113.2F5, TNF, PLAT, VEGFA, IL8, IFNG
39actinomycin d448.1IL8, CSF2, VEGFA, TNF, IFNG, PLAT
40fibrinogen448.1F5, ELANE, PLAT, HMGB1, TNF
41endotoxin448.0IL8, CSF2, F5, HMGB1, ELANE, IFNG
42sb 20358044 619.0HMGB1, VEGFA, CSF2, IL8, TNF, IFNG
43pge2448.0VEGFA, IL8, SAG, CSF2, ELANE, TNF
44cysteine448.0PLAT, IL8, IFNG, F5, ELANE, HMGB1
45cycloheximide447.9CSF2, PLAT, IFNG, PRF1, TNF, VEGFA
46heparin44 28 24 1110.8PLAT, IL8, ELANE, SAG, VEGFA, CSF2
47cyclosporin a44 28 619.8CSF2, TNF, IFNG, IL8, ELANE, HMGB1
48retinoic acid44 248.8CSF2, DEFB1, TNF, ELANE, IFNG, F5
49dexamethasone44 50 28 1110.7VEGFA, TNF, DEFB1, HMGB1, CSF2, IL8
50serine446.9F5, PLAT, LACTB, SAG, IL8, CCNE1

GO Terms for genes affiliated with Endophthalmitis

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Cellular components related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2PLAT, ELANE, VEGFA
2cell surfaceGO:0099867.8VEGFA, TNF, ELANE, PLAT, HMGB1
3extracellular spaceGO:0056156.8VEGFA, TNF, IFNG, IL8, PLAT, CSF2
4extracellular regionGO:0055766.1HMGB1, DEFB1, VEGFA, TNF, PRF1, ELANE

Biological processes related to Endophthalmitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:03274710.0CSF2, IFNG
2positive regulation of podosome assemblyGO:0718039.9CSF2, TNF
3positive regulation of interleukin-8 biosynthetic processGO:0454169.9ELANE, TNF
4positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8IFNG, TNF
6positive regulation of chemokine biosynthetic processGO:0450809.8IFNG, TNF
7embryonic digestive tract developmentGO:0485669.7IL8, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
9defense response to bacteriumGO:0427429.7DEFB1, ELANE, IFNG
10induction of positive chemotaxisGO:0509309.6VEGFA, IL8
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6CSF2, TNF
12positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
13cellular response to lipopolysaccharideGO:0712229.6IFNG, IL8, CSF2
14positive regulation of protein complex assemblyGO:0313349.6TNF, VEGFA
15protein import into nucleus, translocationGO:0000609.6IFNG, TNF
16negative regulation of growth of symbiont in hostGO:0441309.5IFNG, ELANE, TNF
17positive regulation of MAP kinase activityGO:0434069.4VEGFA, TNF, ELANE
18positive chemotaxisGO:0509189.2HMGB1, VEGFA
19positive regulation of nitric oxide biosynthetic processGO:0454299.2IFNG, TNF
20response to hypoxiaGO:0016669.1PLAT, TNF, VEGFA
21apoptotic processGO:0069158.7TNF, PRF1, IFNG, HMGB1
22negative regulation of transcription from RNA polymerase II promoterGO:0001228.4VEGFA, TNF, ELANE, IFNG, HMGB1

Molecular functions related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.3HMGB1, VEGFA
2serine-type endopeptidase activityGO:0042529.2ELANE, PLAT, F5
3cytokine activityGO:0051258.0HMGB1, CSF2, IFNG, TNF, VEGFA
4protein bindingGO:0055156.4ELANE, PRF1, TNF, VEGFA, CCNE1, IL8

Products for genes affiliated with Endophthalmitis

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  • Antibodies
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Sources for Endophthalmitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet