MCID: END047
MIFTS: 51

Endophthalmitis malady

Eye diseases, Rare diseases categories

Aliases & Classifications for Endophthalmitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 61UMLS via Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Endophthalmitis, Aliases & Descriptions:

Name: Endophthalmitis 9 11 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 47 
Rare eye diseases


External Ids:

Disease Ontology9 DOID:4692
NCIt38 C34586
MeSH33 D009877
Orphanet47 199323
UMLS via Orphanet61 C0014236
MESH via Orphanet34 D009877
ICD10 via Orphanet26 H44.0, H44.1
ICD1025 H45.1

Summaries for Endophthalmitis

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Wikipedia:63 Endophthalmitis is an inflammation of the internal coats of the eye. It is a possible complication of... more...

MalaCards based summary: Endophthalmitis is related to retinal vasculitis and endocarditis. An important gene associated with Endophthalmitis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are IL12 signaling mediated by STAT4 and Immune response IL 12 signaling pathway. The compounds cilomilast and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Disease Ontology:9 A globe disease that is characterized by inflammation of the inside of the eye.

Related Diseases for Endophthalmitis

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Diseases in the Endophthalmitis family:

Acute Endophthalmitis Chronic Endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis31.1SAG
2endocarditis30.9LACTB, PRF1
3meningitis30.9PRF1, IL8, LACTB
4prostatitis30.7LACTB
5bacterial meningitis30.6IL8, LACTB
6uveitis30.5SAG, IFNG, TNF
7central retinal artery occlusion30.5PLAT
8retinal detachment30.5PLAT, VEGFA
9aspergillosis30.5ELANE, IFNG
10candidiasis30.5IFNG
11vasculitis30.4TNF, SAG, ELANE
12neutropenia30.2CSF2, LACTB, ELANE
13bronchiectasis30.2IL8, ELANE
14disseminated intravascular coagulation30.1PLAT, ELANE, F5
15arthritis29.9TNF, IL8
16pneumonia29.8HMGB1, CSF2, IL8, ELANE, LACTB, PRF1
17leukemia29.5HMGB1, TNF, LACTB, IFNG, CSF2
18tuberculosis29.4PRF1, SAG, LACTB, IFNG, TNF
19cataract10.9
20acute endophthalmitis10.7
21chronic endophthalmitis10.6
22eales disease10.6SAG
23pustulosis palmaris et plantaris10.5ELANE
24arthus reaction10.5ELANE
25tonsillitis10.5LACTB
26felty's syndrome10.5CSF2
27pharyngitis10.5LACTB
28branch retinal artery occlusion10.5F5
29retinal vascular occlusion10.5F5
30retinitis10.5
31endotheliitis10.5
32cardiac rupture10.5PLAT
33periodontitis10.5IL8
34coronary thrombosis10.4PLAT
35keratitis10.4
36exudative vitreoretinopathy 110.4VEGFA
37sinusitis10.4LACTB
38stomatitis10.4CSF2
39cellulitis10.4
40stenotrophomonas maltophilia10.4
41aplastic anemia10.4IFNG
42capillary leak syndrome10.4ELANE, CSF2
43orbital cellulitis10.4
44neutropenia, cyclic10.4CSF2, ELANE
45sympathetic ophthalmia10.4
46hypopyon10.4
47severe congenital neutropenia10.4ELANE, CSF2
48purulent endophthalmitis10.3
49otitis media10.3DEFB1, LACTB
50corneal ulcer10.3

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to endophthalmitis

Symptoms for Endophthalmitis

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Drugs & Therapeutics for Endophthalmitis

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Drug clinical trials:

Search ClinicalTrials for Endophthalmitis

Search NIH Clinical Center for Endophthalmitis

Genetic Tests for Endophthalmitis

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Anatomical Context for Endophthalmitis

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MalaCards organs/tissues related to Endophthalmitis:

31
Eye, Endothelial, Liver, Lung, Retina, Testes, Brain, Cortex, Prostate, Pituitary

Animal Models for Endophthalmitis or affiliated genes

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MGI Mouse Phenotypes related to Endophthalmitis:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2PLAT, IFNG, CCNE1, TNF, VEGFA
2MP:00053798.2VEGFA, TNF, PRF1, CCNE1, IFNG, CSF2
3MP:00053828.1VEGFA, TNF, IFNG, PLAT, CSF2
4MP:00020068.1VEGFA, TNF, PRF1, ELANE, CCNE1, IFNG
5MP:00053708.0VEGFA, TNF, PRF1, IFNG, F5
6MP:00107718.0VEGFA, TNF, PRF1, CCNE1, IFNG, CSF2
7MP:00053908.0VEGFA, TNF, CCNE1, IFNG, PLAT, CSF2
8MP:00053807.9VEGFA, TNF, CCNE1, IFNG, CSF2, F5
9MP:00053897.9VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
10MP:00053917.9VEGFA, TNF, SAG, IFNG, PLAT, HMGB1
11MP:00053887.9VEGFA, TNF, IFNG, PLAT, CSF2, HMGB1
12MP:00053857.7VEGFA, TNF, CCNE1, IFNG, PLAT, CSF2
13MP:00036317.6VEGFA, TNF, SAG, PRF1, CCNE1, IFNG
14MP:00053847.4VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
15MP:00053977.3VEGFA, TNF, PRF1, ELANE, CCNE1, IFNG
16MP:00053867.1VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
17MP:00053787.1VEGFA, TNF, PRF1, CCNE1, IFNG, PLAT
18MP:00053767.0VEGFA, TNF, PRF1, ELANE, IFNG, PLAT
19MP:00053877.0CSF2, DEFB1, VEGFA, TNF, PRF1, ELANE
20MP:00107686.5DEFB1, VEGFA, TNF, PRF1, ELANE, CCNE1

Publications for Endophthalmitis

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Articles related to Endophthalmitis:

(show top 50)    (show all 710)
idTitleAuthorsYear
1
Group A streptococcal endophthalmitis complicating a sore throat in a 2-year-old child. (25858925)
2015
2
Concurrent Endophthalmitis and Orbital Cellulitis From Metastatic Klebsiella pneumonia Liver Abscess. (25186218)
2014
3
A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors. (24420916)
2014
4
Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis. (24613894)
2014
5
Late surgical complications to endophthalmitis after cataract surgery in the post-EVS era. (25315849)
2014
6
A case of endogenous endophthalmitis complicated by neutropenia following bacteremia with Streptococcus mitis resistant to beta-lactam antibiotics. (22830590)
2013
7
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
8
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. (23857416)
2013
9
Risk factors for acute endophthalmitis following cataract surgery: a systematic review and meta-analysis. (23990980)
2013
10
NO CASES OF ENDOPHTHALMITIS AFTER 20,293 INTRAVITREAL INJECTIONS IN AN OPERATING ROOM SETTING. (24317292)
2013
11
ENDOPHTHALMITIS CAUSED BY ACHROMOBACTER XYLOSOXIDANS AFTER CATARACT SURGERY. (24150240)
2013
12
Endophthalmitis following intravitreal anti-VEGF injections in ambulatory surgical centre facility: incidence, management and outcome. (24064940)
2013
13
Endophthalmitis: an unusual presentation of bacteremia. (23262812)
2013
14
Incidence of acute endophthalmitis after intravitreal bevacizumab injection in a single clinical center. (23400076)
2013
15
Factors determining visual outcome in endogenous Candida endophthalmitis. (22298012)
2012
16
Endophthalmitis is not a "never event". (22858024)
2012
17
Diagnostic dilemmas in retinitis and endophthalmitis. (22116459)
2012
18
Real-time polymerase chain reaction in the diagnosis of acute postoperative endophthalmitis. (23149369)
2012
19
Use of DNA microarray analysis in diagnosis of bacterial and fungal endophthalmitis. (22399844)
2012
20
Recurrent endophthalmitis after trabeculectomy for glaucoma: importance of timely filtering bleb coverage for the conjunctiva. (23185177)
2012
21
Delayed- versus acute-onset endophthalmitis after cataract surgery. (22813452)
2012
22
Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA. (22527320)
2012
23
Surveillance of late-onset bleb leak, blebitis and bleb-related endophthalmitis--a UK incidence study. (22249317)
2012
24
Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes. (22709846)
2012
25
The comparison of fluoroquinolones to nonfluoroquinolone antibacterial agents for the prevention of endophthalmitis in a rabbit model. (22925112)
2012
26
Intravitreal daptomycin in a case of bilateral endogenous endophthalmitis. (22776941)
2012
27
Prophylactic effect of topical fluoroquinolones in a rabbit model of Staphylococcus aureus endophthalmitis. (22077488)
2012
28
Infectious keratitis progressing to endophthalmitis: a 15-year study of microbiology, associated factors, and clinical outcomes. (22858123)
2012
29
Endogenous Candida albicans endophthalmitis following spontaneous abortion and IUD removal. (22165949)
2011
30
Self-induced Elizabethkingia meningoseptica endophthalmitis: a case report. (21745367)
2011
31
Severe acute endogenous endophthalmitis with Staphylococcus epidermidis in a systemically well patient. (23861621)
2011
32
Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. (21705087)
2011
33
Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis. (21358364)
2011
34
Clinical review of endogenous endophthalmitis in Korea: a 14-year review of culture positive cases of two large hospitals. (21623606)
2011
35
Late-onset Citrobacter koseri endophthalmitis with suture exposure after secondary intraocular lens implantation. (21860579)
2011
36
Preventive scleral buckling and silicone oil tamponade are important for posttraumatic endophthalmitis successfully managed with vitrectomy. (21893970)
2011
37
Obviating endophthalmitis after cataract surgery: excellent wound closure is the key. (22084227)
2011
38
A cluster of acute-onset postoperative endophthalmitis over a 1-month period: investigation of an outbreak caused by uncommon species. (20733020)
2011
39
Acute postoperative endophthalmitis in a patient with Darier's disease. (20806743)
2010
40
A case of bilateral endogenous Pantoea agglomerans endophthalmitis with interstitial lung disease. (20714391)
2010
41
Case of endogenous endophthalmitis caused by Streptococcus equisimilis. (20823933)
2010
42
Re: Infectious endophthalmitis after intravitreal injection of antiangiogenic agents. (21060278)
2010
43
Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. (20370345)
2010
44
Postoperative mycotic endophthalmitis. (20610105)
2010
45
Bilateral endophthalmitis as the initial presentation of bacterial meningitis. (20046699)
2009
46
Actinomyces neuii subspecies anitratus chronic endophthalmitis after cataract surgery. (17534833)
2007
47
Risk factors of acute endophthalmitis after cataract extraction: a case-control study in Asian eyes. (14693767)
2004
48
Pink hypopyon: a sign of Serratia marcescens endophthalmitis. (1486086)
1992
49
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (6985228)
1982
50
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (206999)
1977

Variations for Endophthalmitis

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Expression for genes affiliated with Endophthalmitis

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Search GEO for disease gene expression data for Endophthalmitis.

Pathways for genes affiliated with Endophthalmitis

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Pathways related to Endophthalmitis according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, PRF1
29.8IFNG, PRF1
39.7CSF2, IL8
4
Show member pathways
9.7PRF1, HMGB1
59.5TNF, IL8
69.5IFNG, TNF
7
Show member pathways
9.4CCNE1, PRF1, TNF
89.4IFNG, VEGFA
9
Show member pathways
9.3CSF2, IL8, IFNG
109.3IFNG, IL8, CSF2
11
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.3IFNG, PRF1, TNF
12
Show member pathways
9.3TNF, PRF1, IFNG
139.2PLAT, IL8, IFNG
14
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.2CSF2, IFNG, TNF
159.2CSF2, IFNG, TNF
16
Show member pathways
9.2CSF2, IFNG, TNF
17
Show member pathways
Signaling Pathways in Glioblastoma36
9.2VEGFA, CCNE1, IL8
18
Show member pathways
thioredoxin pathway36
9.1TNF, IFNG, PLAT
199.1TNF, IFNG, IL8
20
Show member pathways
Immune response MIF in innate immunity response58
9.1IL8, IFNG, TNF
219.1TNF, IFNG, IL8
229.1IL8, IFNG, TNF
239.1TNF, IFNG, IL8
24
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1IL8, IFNG, TNF
259.1ELANE, IL8, PLAT, CSF2
269.1CCNE1, TNF, VEGFA
27
Show member pathways
9.0TNF, IL8, HMGB1
28
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.0VEGFA, TNF, CSF2
29
Show member pathways
Immune response CD16 signaling in NK cells58
8.9CSF2, IFNG, PRF1, TNF
308.9IL8, TNF, VEGFA
31
Show member pathways
8.8IL8, IFNG, CCNE1, TNF
32
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8TNF, CCNE1, IFNG, IL8
338.8TNF, IFNG, IL8, CSF2
34
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.8CSF2, IL8, IFNG, TNF
358.8TNF, ELANE, PLAT, HMGB1
36
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.7TNF, CCNE1, IFNG, HMGB1
378.1CSF2, IL8, IFNG, TNF, VEGFA
38
Show member pathways
8.1CSF2, IL8, IFNG, TNF, VEGFA

Compounds for genes affiliated with Endophthalmitis

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Compounds related to Endophthalmitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1cilomilast439.5TNF, IL8, ELANE
2ulinastatin439.5IL8, ELANE, TNF
3protamine439.4ELANE, PLAT, F5, IL8
4mip 1alpha439.3CSF2, IL8, TNF
5anaphylatoxin439.3HMGB1, CSF2, ELANE, IL8
6vancomycin43 1210.3LACTB, ELANE, F5
7aprotinin43 1210.2IL8, F5, PLAT, ELANE
8n-formylmethionyl-leucylphenylalanine439.2TNF, CSF2, IL8, ELANE
9ivig439.2CSF2, TNF, SAG, IFNG
10polymyxin b439.2TNF, DEFB1, IL8, IFNG
11il-12439.2IL8, CSF2, IFNG, TNF
12imiquimod43 59 28 1212.2TNF, IFNG, IL8, CSF2
13ceftriaxone43 1210.2PLAT, LACTB, F5
14taurine chloramine439.2IL8, F5, TNF, IFNG
15rolipram43 59 2811.2ELANE, TNF, IL8, IFNG
16budesonide43 49 1211.2IL8, CSF2, IFNG, TNF
17poly(i-c)439.1CSF2, IL8, IFNG, TNF
18il 10439.1TNF, IL8, IFNG, CSF2
19tarc439.1TNF, IFNG, IL8, CSF2
20azithromycin43 1210.1LACTB, CSF2, IL8
21gold sodium thiomalate439.0IL8, TNF, IFNG
22ofloxacin43 2 1211.0F5, CSF2, LACTB
23gabexate mesilate439.0TNF, ELANE, IL8, PLAT, F5
24fluticasone propionate43 49 59 1211.9TNF, ELANE, IFNG, IL8, CSF2
25pentoxifylline43 129.9ELANE, CSF2, IL8, IFNG, TNF
26neopterin438.9TNF, CSF2, IL8, IFNG, ELANE
27triptolide438.9TNF, VEGFA, IFNG, IL8
28rantes438.8DEFB1, IFNG, IL8, CSF2, TNF
29prostacyclin438.7TNF, VEGFA, F5, PLAT, ELANE
30thalidomide43 49 59 1211.6CSF2, IFNG, VEGFA, TNF
3115-deoxy-delta-12,14-prostaglandin j2438.6TNF, VEGFA, IL8, IFNG, CSF2
32hydrocortisone43 2 59 1211.6F5, IL8, IFNG, ELANE, CSF2, TNF
33carboplatin43 49 1210.6HMGB1, IFNG, VEGFA, CSF2
34superoxide43 249.5TNF, HMGB1, CSF2, ELANE, PRF1, IL8
35butyrate438.4HMGB1, CSF2, IL8, TNF, IFNG
36lactate438.4HMGB1, CSF2, TNF, IL8, ELANE, F5
37gm-csf43 289.3TNF, IFNG, ELANE, VEGFA, IL8, CSF2
38simvastatin43 49 59 28 24 1213.2F5, TNF, PLAT, VEGFA, IL8, IFNG
39actinomycin d438.1IL8, CSF2, VEGFA, TNF, IFNG, PLAT
40fibrinogen438.1F5, ELANE, PLAT, HMGB1, TNF
41endotoxin438.0IL8, CSF2, F5, HMGB1, ELANE, IFNG
42sb 20358043 599.0HMGB1, VEGFA, CSF2, IL8, TNF, IFNG
43pge2438.0VEGFA, IL8, SAG, CSF2, ELANE, TNF
44cysteine438.0PLAT, IL8, IFNG, F5, ELANE, HMGB1
45cycloheximide437.9CSF2, PLAT, IFNG, PRF1, TNF, VEGFA
46heparin43 28 24 1210.8PLAT, IL8, ELANE, SAG, VEGFA, CSF2
47cyclosporin a43 28 599.8CSF2, TNF, IFNG, IL8, ELANE, HMGB1
48retinoic acid43 248.8CSF2, DEFB1, TNF, ELANE, IFNG, F5
49dexamethasone43 49 28 1210.7VEGFA, TNF, DEFB1, HMGB1, CSF2, IL8
50serine436.9F5, PLAT, LACTB, SAG, IL8, CCNE1

GO Terms for genes affiliated with Endophthalmitis

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Cellular components related to Endophthalmitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.2PLAT, ELANE, VEGFA
2cell surfaceGO:00099867.8VEGFA, TNF, ELANE, PLAT, HMGB1
3extracellular spaceGO:00056156.8VEGFA, TNF, IFNG, IL8, PLAT, CSF2
4extracellular regionGO:00055766.1HMGB1, DEFB1, VEGFA, TNF, PRF1, ELANE

Biological processes related to Endophthalmitis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:003274710.0CSF2, IFNG
2positive regulation of podosome assemblyGO:00718039.9CSF2, TNF
3positive regulation of interleukin-8 biosynthetic processGO:00454169.9ELANE, TNF
4positive regulation of vitamin D biosynthetic processGO:00605579.8IFNG, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8IFNG, TNF
6positive regulation of chemokine biosynthetic processGO:00450809.8IFNG, TNF
7embryonic digestive tract developmentGO:00485669.7IL8, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:00510449.7IFNG, TNF
9defense response to bacteriumGO:00427429.7DEFB1, ELANE, IFNG
10induction of positive chemotaxisGO:00509309.6VEGFA, IL8
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.6CSF2, TNF
12positive regulation of osteoclast differentiationGO:00456729.6TNF, IFNG
13cellular response to lipopolysaccharideGO:00712229.6IFNG, IL8, CSF2
14positive regulation of protein complex assemblyGO:00313349.6TNF, VEGFA
15protein import into nucleus, translocationGO:00000609.6IFNG, TNF
16negative regulation of growth of symbiont in hostGO:00441309.5IFNG, ELANE, TNF
17positive regulation of MAP kinase activityGO:00434069.4VEGFA, TNF, ELANE
18positive chemotaxisGO:00509189.2HMGB1, VEGFA
19positive regulation of nitric oxide biosynthetic processGO:00454299.2IFNG, TNF
20response to hypoxiaGO:00016669.1PLAT, TNF, VEGFA
21apoptotic processGO:00069158.7TNF, PRF1, IFNG, HMGB1
22negative regulation of transcription from RNA polymerase II promoterGO:00001228.4VEGFA, TNF, ELANE, IFNG, HMGB1

Molecular functions related to Endophthalmitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:00420569.3HMGB1, VEGFA
2serine-type endopeptidase activityGO:00042529.2ELANE, PLAT, F5
3cytokine activityGO:00051258.0HMGB1, CSF2, IFNG, TNF, VEGFA
4protein bindingGO:00055156.4ELANE, PRF1, TNF, VEGFA, CCNE1, IL8

Products for genes affiliated with Endophthalmitis

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Sources for Endophthalmitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet