MCID: END047
MIFTS: 56

Endophthalmitis malady

Eye diseases category

Summaries for Endophthalmitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Endophthalmitis is an inflammation of the internal coats of the eye. It is a possible complication of... more...

MalaCards: Endophthalmitis is related to pneumonia and retinitis. An important gene associated with Endophthalmitis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rheumatoid arthritis and Downstream signaling in naive CD8+ T cells. The compounds rolipram and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related mouse phenotypes are integument and tumorigenesis.

Disease Ontology:8 A globe disease that is characterized by inflammation of the inside of the eye.

Aliases & Classifications for Endophthalmitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

endophthalmitis 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:4692
NCIt39 C34586
MeSH34 D009877
MESH via Orphanet35 D009877
ICD10 via Orphanet26 H44.0, H44.1
SNOMED-CT via Orphanet57 1847009
UMLS via Orphanet61 C0014236
ICD1025 H45.1

Related Diseases for Endophthalmitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Endophthalmitis family:

Acute Endophthalmitis Chronic Endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 244)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.7CSF2, TNF, PRF1, DEFB1, IL8, HMGB1
2retinitis30.6SAG
3meningitis30.5PRF1, IL8, LACTB
4uveitis30.5TNF, SAG, IFNG
5endocarditis30.2NPL, PRF1, LACTB
6retinal vasculitis30.2SAG
7vasculitis30.2ELANE, TNF, SAG
8acute leukemia30.1LACTB, CSF2
9retinal detachment30.1PLAT, VEGFA
10leukemia30.1IFNG, CSF2, TNF, HMGB1, LACTB
11herpes simplex30.0HMGB1
12aspergillosis29.9ELANE, IFNG
13acquired immunodeficiency syndrome29.7CSF2
14pyelonephritis29.7LACTB
15retinoblastoma29.7HMGB1, SAG, CCNE1
16interstitial lung disease29.7TNF
17crohn's disease29.7TNF
18influenza29.7LACTB, IFNG
19neutropenia29.7CSF2, LACTB, ELANE
20bronchiectasis29.7IL8, ELANE
21central retinal artery occlusion29.7PLAT
22disseminated intravascular coagulation29.7F5, PLAT, ELANE
23age related macular degeneration29.7PLAT, VEGFA
24graft versus host disease29.7TNF, CSF2, IFNG
25tuberculosis29.7IFNG, SAG, TNF, PRF1, LACTB
26arthritis29.7IFNG, CSF2, TNF, IL8, HMGB1, LACTB
27cataract10.8
28acute endophthalmitis10.8
29chronic endophthalmitis10.6
30keratitis10.4
31glaucoma10.4
32cellulitis10.3
33orbital cellulitis10.3
34sympathetic ophthalmia10.3
35hypopyon10.3
36corneal ulcer10.3
37purulent endophthalmitis10.3
38acne10.2
39scleritis10.2
40phakoanaphylactic uveitis10.2
41bacterial meningitis10.1
42fusariosis10.0
43posterior uveitis10.0
44candidiasis10.0
45cholecystitis10.0
46chorioretinitis10.0
47conjunctivitis10.0
48factitious disorder10.0
49iridocyclitis10.0
50pterygium10.0

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to endophthalmitis

Clinical Features for Endophthalmitis

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Drugs & Therapeutics for Endophthalmitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endophthalmitis

Drug clinical trials:

Search ClinicalTrials for Endophthalmitis

Search NIH Clinical Center for Endophthalmitis

Search CenterWatch for Endophthalmitis

Genetic Tests for Endophthalmitis

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Anatomical Context for Endophthalmitis

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32MalaCards
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MalaCards organs/tissues related to Endophthalmitis:

32
Eye, Endothelial, Liver, Testes, Lung, Retina, Brain, Cortex

Animal Models for Endophthalmitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Endophthalmitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.7CCNE1, PRF1, VEGFA
2MP:00020069.4CCNE1, IFNG, TNF, ELANE
3MP:00053919.1SAG, CRYGS, PLAT, HMGB1
4MP:00053768.7NPL, F5, PRF1, PLAT, ELANE, IFNG
5MP:00053977.7CCNE1, IFNG, CSF2, TNF, PRF1, VEGFA
6MP:00053877.3ELANE, CCNE1, IFNG, CSF2, TNF, NPL
7MP:00053867.1CCNE1, IFNG, CSF2, TNF, F5, PRF1
8MP:00107686.9CCNE1, IFNG, CSF2, TNF, F5, PRF1

Publications for Endophthalmitis

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Sources:
50PubMed
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Articles related to Endophthalmitis:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
Ocular Penetration and Efficacy of Levofloxacin Using Different Drug-Delivery Techniques for the Prevention of Endophthalmitis in Rabbit Eyes with Posterior Capsule Rupture. (24410272)
2014
2
Risk factors for acute endophthalmitis following cataract surgery: a systematic review and meta-analysis. (23990980)
2013
3
NO CASES OF ENDOPHTHALMITIS AFTER 20,293 INTRAVITREAL INJECTIONS IN AN OPERATING ROOM SETTING. (24317292)
2013
4
Pseudomonas aeruginosa endophthalmitis masquerading as chronic uveitis. (23803484)
2013
5
Pars plana vitrectomy in the management of patients diagnosed with endophthalmitis following intravitreal anti-vascular endothelial growth factor injection. (23492945)
2013
6
Retraction. "Epidemiological evaluation of intraoperative antibiosis as a protective agent against endophthalmitis after cataract surgery" by F. Krummenauer, S. Kurz and H.B. Dick. (23509840)
2013
7
Post-traumatic vancomycin-resistant enterococcal endophthalmitis. (23514354)
2013
8
A rare case of endogenous Aspergillus conicus endophthalmitis in an immunocompromised patient. (23514122)
2013
9
Bilateral Candida endophthalmitis in a premature infant. (23522946)
2013
10
Delayed-onset endophthalmitis associated with corneal suture infections. (23758694)
2013
11
Late-onset bleb-related endophthalmitis caused by Streptococcus pseudopneumoniae. (23884602)
2013
12
Polymicrobial endophthalmitis: prevalence, causative organisms, and visual outcomes. (23514425)
2013
13
Rapid diagnosis of Mycobacterium abscessus endophthalmitis. (23579395)
2013
14
Intravitreal daptomycin in a case of bilateral endogenous endophthalmitis. (22776941)
2012
15
An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumab. (22264943)
2012
16
Postcataract surgery endophthalmitis in the United States: analysis of the complete 2003 to 2004 Medicare database of cataract surgeries. (22297029)
2012
17
Man with blurred vision. Endogenous candida endophthalmitis caused by urinary tract infection. (22265136)
2012
18
Relationship between baseline clinical data and microbiologic spectrum in 100 patients with acute postcataract endophthalmitis. (21968507)
2012
19
Bleb-associated endophthalmitis in a Chinese population (2003-2010): clinical characteristics and visual outcome. (22287170)
2012
20
A case of endophthalmitis associated with limbal relaxing incision. (22569388)
2012
21
Endophthalmitis following intravitreal injections. (22048244)
2012
22
Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes. (21917234)
2012
23
Risk factors for endophthalmitis and retinal detachment with retained intraocular foreign bodies. (22619702)
2012
24
Rhizobium radiobacter Endophthalmitis following Intravitreal Ranibizumab Injection. (23275789)
2012
25
The diabetic ocular environment facilitates the development of endogenous bacterial endophthalmitis. (23036996)
2012
26
Preventive scleral buckling and silicone oil tamponade are important for posttraumatic endophthalmitis successfully managed with vitrectomy. (21893970)
2011
27
Pseudomonas aeruginosa endophthalmitis after penetrating keratoplasty transmitted from the same donor to two recipients confirmed by pulsed-field gel electrophoresis. (21775545)
2011
28
Biocompatibility of pooled human immunoglobulin (Gamunex 10%a8c) with ocular infusion solutions (BSSa8c and BSS Plusa8c): an in vitro evaluation of a potential antitoxin treatment for infectious endophthalmitis. (21631364)
2011
29
Endophthalmitis in microincision vitrectomy: outcomes of gas-filled eyes. (21878799)
2011
30
Endophthalmitis after pars plana vitrectomy: results of the Pan American Collaborative Retina Study Group. (21394065)
2011
31
Declining incidence of neonatal endophthalmitis in the United States. (20970776)
2011
32
Prophylactic effect of intravenous moxifloxacin in a rabbit model of Staphylococcus epidermidis endophthalmitis. (21169530)
2011
33
Outcomes of post-cataract surgery endophthalmitis referred to a tertiary center from local hospitals in the south of China. (21710121)
2011
34
The concentration of povidone-iodine for preoperative disinfection: relation to endophthalmitis incidence. (21784195)
2011
35
Quinupristin/dalfopristin in Staphylococcus aureus endophthalmitis: a case report. (21453475)
2011
36
Preventing endophthalmitis after cataract surgeries. (21454380)
2011
37
Intravenous fluconazole for bilateral endogenous Candida endophthalmitis. (21235384)
2011
38
Klebsiella pneumoniae endophthalmitis secondary to liver abscess presenting as acute iridocyclitis. (19772282)
2009
39
Candida glabrata endophthalmitis following penetrating keratoplasty. (19251157)
2009
40
Influence of intraocular lens material on the development of acute endophthalmitis after cataract surgery? (16980932)
2008
41
Actinomyces neuii subspecies anitratus chronic endophthalmitis after cataract surgery. (17534833)
2007
42
Endogenous endophthalmitis in a rheumatoid patient on tumor necrosis factor alpha blocker. (17456948)
2007
43
Incidence of corneal ulcer in hydrogel contact lens wearers and post-cataract endophthalmitis. Do they Compare? (16303528)
2004
44
Endophthalmitis caused by Mycobacterium abscessus. (14700104)
2003
45
Internal ophthalmomyiasis presenting as endophthalmitis associated with an intraocular foreign body. (14620752)
2003
46
Xanthogranulomatous cholecystitis with a liver abscess and metastatic endophthalmitis: report of a case. (11991520)
2002
47
Endophthalmitis and cystoid macular edema after astigmatic keratotomy. (7970525)
1994
48
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (6985228)
1982
49
CHRONIC ENDOPHTHALMITIS DUE TO TOXOCARA. (18170725)
1961
50
Endophthalmitis phaco-anaphylactia with granulomatous iritis; clinico-pathologic case report. (13092203)
1953

Genetic Variations for Endophthalmitis

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Expression for genes affiliated with Endophthalmitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endophthalmitis

Search GEO for disease gene expression data for Endophthalmitis.

Pathways for genes affiliated with Endophthalmitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Endophthalmitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Endophthalmitis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.6ELANE
2ulinastatin4410.5ELANE
3pentoxifylline44 1111.4CSF2, ELANE
4hydrocortisone44 2 59 1113.3ELANE, IL8
5protamine4410.2F5, PLAT
6aebsf4410.2ELANE
7gm-csf44 2811.1TNF, IFNG
8endotoxin4410.1F5, HMGB1
9dexamethasone44 49 28 1113.1DEFB1, VEGFA
10pge24410.0VEGFA, SAG, CSF2
11cilomilast449.8ELANE, IL8, TNF
12mip 1alpha449.7IL8, CSF2, TNF
13vancomycin44 1110.7LACTB, F5, ELANE
14ceftriaxone44 1110.6LACTB, PLAT, F5
15azithromycin44 1110.6IL8, LACTB, CSF2
16gold sodium thiomalate449.6IL8, IFNG, TNF
17ofloxacin44 2 1111.5F5, LACTB, CSF2
18superoxide44 2410.5CSF2, TNF, PRF1, ELANE
19ivig449.5TNF, SAG, IFNG, CSF2
20rantes449.5CSF2, IFNG, TNF
21cyclosporin a44 28 5911.5HMGB1, ELANE, SAG, IFNG
22polymyxin b449.5IL8, IFNG, TNF, DEFB1
23n-formylmethionyl-leucylphenylalanine449.5CSF2, ELANE, IL8, TNF
24il-12449.5TNF, IL8, CSF2, IFNG
25imiquimod44 28 59 1112.5IFNG, TNF, CSF2, IL8
26budesonide44 49 1111.5IFNG, CSF2, TNF, IL8
27anaphylatoxin449.5CSF2, IL8, HMGB1, ELANE
28taurine chloramine449.5TNF, IL8, F5, IFNG
29poly(i-c)449.5IFNG, CSF2, TNF, IL8
30il 10449.5TNF, IL8, IFNG, CSF2
31tarc449.4TNF, CSF2, IFNG, IL8
32butyrate449.4CSF2, HMGB1
33staurosporin449.3IFNG, TNF, IL8
34triptolide449.3IFNG, TNF, IL8, VEGFA
35aprotinin44 1110.3F5, IL8, PLAT, ELANE
36gabexate mesilate449.3IL8, PLAT, F5, TNF, ELANE
37fluticasone propionate44 49 59 1112.2CSF2, IFNG, TNF, ELANE, IL8
38neopterin449.2TNF, CSF2, IFNG, ELANE, IL8
39thalidomide44 49 59 1112.1VEGFA, CSF2, IFNG, TNF
40leukotriene b444 59 2411.1CSF2, IL8, TNF, ELANE
41carboplatin44 49 1111.1CSF2, VEGFA, HMGB1, IFNG
4215-deoxy-delta-12,14-prostaglandin j2449.0IL8, VEGFA, TNF, CSF2, IFNG
43heparin44 28 11 2412.0IL8, ELANE, VEGFA, CSF2, HMGB1
44prostacyclin449.0ELANE, TNF, PLAT, F5, VEGFA
45serine448.9HMGB1, LACTB, CCNE1, TNF, IL8
46simvastatin44 49 59 28 11 2413.7PLAT, F5, IL8, VEGFA, IFNG, TNF
47actinomycin d448.7IFNG, VEGFA, IL8, PLAT, CSF2, TNF
48lactate448.6ELANE, HMGB1, CSF2, TNF, F5, IL8
49sb 20358044 599.5CSF2, HMGB1, IL8, VEGFA, TNF, IFNG
50retinoic acid44 249.1CSF2, HMGB1, PLAT, DEFB1, TNF, F5

GO Terms for genes affiliated with Endophthalmitis

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16Gene Ontology
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Cellular components related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4ELANE, PLAT, VEGFA
2cell surfaceGO:0099868.2TNF, VEGFA, PLAT, HMGB1, ELANE
3extracellular spaceGO:0056157.4IFNG, CSF2, TNF, F5, VEGFA, IL8
4extracellular regionGO:0055766.8ELANE, IFNG, CSF2, TNF, F5, PRF1

Biological processes related to Endophthalmitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:03274710.0IFNG, CSF2
2positive regulation of vitamin D biosynthetic processGO:0605579.9IFNG, TNF
3positive regulation of podosome assemblyGO:0718039.9TNF, CSF2
4positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9TNF, IFNG
5positive regulation of interleukin-8 biosynthetic processGO:0454169.8TNF, ELANE
6negative regulation of growth of symbiont in hostGO:0441309.6TNF, IFNG, ELANE
7positive regulation of protein complex assemblyGO:0313349.6TNF, VEGFA
8positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, TNF
9cellular response to lipopolysaccharideGO:0712229.6IL8, IFNG, CSF2
10positive regulation of MAP kinase activityGO:0434069.5VEGFA, TNF, ELANE
11positive regulation of membrane protein ectodomain proteolysisGO:0510449.4IFNG, TNF

Molecular functions related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.4HMGB1, VEGFA, TNF, CSF2, IFNG

Products for genes affiliated with Endophthalmitis

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  • Antibodies
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Sources for Endophthalmitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet