MCID: END047
MIFTS: 48

Endophthalmitis malady

Eye category

Summaries for Endophthalmitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Endophthalmitis is an inflammation of the internal coats of the eye. It is a possible complication of... more...

MalaCards: Endophthalmitis is related to uveitis and retinal vasculitis. An important gene associated with Endophthalmitis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rheumatoid arthritis and Downstream signaling in naive CD8+ T cells. The compounds rolipram and ulinastatin have been mentioned in the context of this disorder. Related mouse phenotypes are integument and tumorigenesis.

Disease Ontology:8 A globe disease that is characterized by inflammation of the inside of the eye.

Aliases & Classifications for Endophthalmitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

endophthalmitis 8 10 45 49 61


External Ids:

Disease Ontology8 DOID:4692
NCIt40 C34586
MeSH35 D009877
MESH via Orphanet36 D009877
ICD10 via Orphanet26 H44.0, H44.1
SNOMED-CT via Orphanet58 1847009
UMLS via Orphanet62 C0014236
ICD1025 H45.1

Related Diseases for Endophthalmitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Endophthalmitis family:

acute endophthalmitis chronic endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.5TNF, SAG, IFNG
2retinal vasculitis30.2SAG
3vasculitis30.2SAG, ELANE, TNF
4acute leukemia30.1CSF2, LACTB
5sepsis30.1IL8, ELANE, HMGB1, DEFB1, LACTB, F5
6aspergillosis30.0IFNG, ELANE
7leukopenia29.8CSF2
8acquired immunodeficiency syndrome29.8CSF2
9purpura fulminans29.8F5
10bronchiectasis29.8IL8, ELANE
11central retinal artery occlusion29.8PLAT
12graft versus host disease29.8TNF, IFNG, CSF2
13tuberculosis29.7SAG, PRF1, LACTB, IFNG, TNF
14arthritis29.7IFNG, CSF2, TNF, IL8, HMGB1, LACTB
15asthma29.7IFNG, DEFB1, TNF, ELANE, IL8, CSF2
16acute endophthalmitis10.8
17chronic endophthalmitis10.6
18klebsiella10.5
19cellulitis10.4
20orbital cellulitis10.3
21sympathetic ophthalmia10.3
22stenotrophomonas maltophilia10.3
23mycobacterium abscessus10.3
24mycobacterium chelonae10.3
25acne10.2
26phakoanaphylactic uveitis10.2
27meningococcal meningitis10.2
28candida glabrata10.2
29bacteremia10.2
30bacterial meningitis10.1
31fusariosis10.0
32panophthalmitis10.0
33posterior uveitis10.0
34anterior uveitis10.0
35congenital herpes simplex10.0
36eales disease10.0SAG
37hemophagocytic lymphohistiocytosis10.0PRF1
38sinusitis10.0LACTB
39retinitis10.0SAG
40skin disease10.0PRF1
41prostatitis10.0LACTB
42osteomyelitis10.0LACTB
43human immunodeficiency virus infectious disease10.0PRF1
44cholesteatoma10.0DEFB1
45tonsillitis10.0LACTB
46herpes simplex10.0HMGB1
47pelvic inflammatory disease10.0LACTB
48deficiency anemia10.0CSF2
49kawasaki disease10.0ELANE
50hyperglycemia10.0HMGB1

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to endophthalmitis

Clinical Features for Endophthalmitis

Drugs & Therapeutics for Endophthalmitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Endophthalmitis

Drug clinical trials:

Search ClinicalTrials for Endophthalmitis

Search NIH Clinical Center for Endophthalmitis

Search CenterWatch for Endophthalmitis

Genetic Tests for Endophthalmitis

Anatomical Context for Endophthalmitis

Animal Models for Endophthalmitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Endophthalmitis

Sources:
51PubMed
See all sources

Articles related to Endophthalmitis:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
A case of endogenous endophthalmitis complicated by neutropenia following bacteremia with Streptococcus mitis resistant to beta-lactam antibiotics. (22830590)
2013
2
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
3
Endophthalmitis caused by Citrobacter species: a case series. (23769785)
2013
4
Actinomyces endogenous endophthalmitis in a cat following multiple dental extractions. (23281798)
2013
5
Keratitis-induced endophthalmitis. (23823526)
2013
6
Scedosporium prolificans endogenous endophthalmitis. (24210343)
2013
7
Intracameral antibiotics and endophthalmitis incidence. (23332285)
2013
8
The first case of Candida dubliniensis endophthalmitis in North America. (23132215)
2013
9
Infectious endophthalmitis: review of 420 cases. (23403798)
2013
10
Management of a Case of Candida Endogenous Endophthalmitis in a Neonate. (23718255)
2013
11
Antifungal therapy of aspergillosis of the central nervous system and aspergillus endophthalmitis. (23278539)
2013
12
A liver abscess deprived a healthy adult of eyesight: endogenous endophthalmitis associated with a pyogenic liver abscess caused by serotype K1 Klebsiella pneumonia. (23583997)
2013
13
ENDOGENOUS ENDOPHTHALMITIS IN THE KOREAN POPULATION: A Six-Year Retrospective Study. (24056527)
2013
14
Real-time polymerase chain reaction in the diagnosis of acute postoperative endophthalmitis. (23149369)
2012
15
Use of DNA microarray analysis in diagnosis of bacterial and fungal endophthalmitis. (22399844)
2012
16
Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes. (22709846)
2012
17
The comparison of fluoroquinolones to nonfluoroquinolone antibacterial agents for the prevention of endophthalmitis in a rabbit model. (22925112)
2012
18
Intravitreal tigecycline treatment in experimental Acinetobacter baumannii endophthalmitis. (22546766)
2012
19
Role of adequate wound closure in preventing acute postoperative bacterial endophthalmitis. (22727306)
2012
20
Review of Clinical Features, Microbiological Spectrum, and Treatment Outcomes of Endogenous Endophthalmitis over an 8-Year Period. (23533699)
2012
21
Four cases of endophthalmitis after 25-gauge pars plana vitrectomy. (22969284)
2012
22
Incidence of endophthalmitis and use of antibiotic prophylaxis after intravitreal injections. (22480743)
2012
23
Isolates and antibiotic resistance of culture-proven endophthalmitis cases presented to a referral center in Tehran. (23248536)
2012
24
Resistant Fusarium keratitis progressing to endophthalmitis. (21993589)
2012
25
Management of endophthalmitis while preserving the uninvolved crystalline lens. (22536036)
2012
26
Discrepancy of in-vitro data and clinical efficacy of micafungin against Candida tropicalis endophthalmitis. (22740188)
2012
27
Endophthalmitis following vitrectomy. (22173074)
2012
28
Postcataract endophthalmitis due to Mycobacterium tuberculosis. (21770798)
2011
29
Treatment for fungal endophthalmitis resulting from keratitis. (21163378)
2011
30
Endophthalmitis after cataract surgery in China, 1995-2009. (21855767)
2011
31
Importance of accurate sampling techniques in microbiological diagnosis of endophthalmitis. (23393517)
2011
32
Endophthalmitis caused by Pseudomonas aeruginosa in Taiwan. (21283056)
2011
33
Intraocular penetration of micafungin in patient with Candida albicans endophthalmitis. (21751880)
2011
34
Colletotrichum truncatum: an unusual pathogen causing mycotic keratitis and endophthalmitis. (21653772)
2011
35
Incidence of postoperative endophthalmitis after immediate sequential bilateral cataract surgery. (22108106)
2011
36
An outbreak of Fusarium solani endophthalmitis after cataract surgery in an eye training and research hospital in Istanbul. (21627695)
2011
37
Bilateral endogenous endophthalmitis secondary to Candida albicans. (21642653)
2011
38
Prophylactic antibiotic use after intravitreal injection: effect on endophthalmitis rate. (21659941)
2011
39
Dark hypopyon in Streptococcus bovis endogenous endophthalmitis: clinicopathologic correlations. (21475652)
2011
40
Evaluation of the incidence of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor. (21811052)
2011
41
Endogenous endophthalmitis caused by bacteria with unusual morphology in direct microscopic examination of the vitreous. (21666329)
2011
42
Endophthalmitis as a complication of an exposed suture following goniotomy. (20635813)
2010
43
Immunization with pneumolysin protects against both retinal and global damage caused by Streptococcus pneumoniae endophthalmitis. (21034245)
2010
44
Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery. (19668397)
2008
45
A case of Enterococcus faecalis endophthalmitis with corneal ulcer. (15635832)
2004
46
Vitrectomy and silicone oil in the treatment of acute endophthalmitis. Preliminary results. (12879720)
2003
47
Two cases of Stenotrophomonas maltophilia endophthalmitis. (12027111)
2002
48
Neonatal candidiasis associated with meningitis and endophthalmitis. (8091973)
1994
49
Early vitrectomy in the treatment of post-operative purulent endophthalmitis. (3499048)
1987
50
Sympathetic ophthalmia following purulent endophthalmitis (postcataract extraction). (14877974)
1951

Genetic Variations for Endophthalmitis

Expression for genes affiliated with Endophthalmitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endophthalmitis

Search GEO for disease gene expression data for Endophthalmitis.

Pathways for genes affiliated with Endophthalmitis

Sources:
30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Endophthalmitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Endophthalmitis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1rolipram45 60 2912.6ELANE
2ulinastatin4510.5ELANE
3pentoxifylline45 1111.4CSF2, ELANE
4hydrocortisone45 2 60 1113.3ELANE, IL8
5protamine4510.2F5, PLAT
6aebsf4510.2ELANE
7gm-csf45 2911.1TNF, IFNG
8endotoxin4510.1F5, HMGB1
9dexamethasone45 50 29 1113.1DEFB1, VEGFA
10pge24510.0VEGFA, SAG, CSF2
11cilomilast459.8ELANE, IL8, TNF
12mip 1alpha459.7IL8, CSF2, TNF
13vancomycin45 1110.7LACTB, F5, ELANE
14ceftriaxone45 1110.6LACTB, PLAT, F5
15azithromycin45 1110.6IL8, LACTB, CSF2
16gold sodium thiomalate459.6IL8, IFNG, TNF
17ofloxacin45 2 1111.5F5, LACTB, CSF2
18superoxide45 2410.5CSF2, TNF, PRF1, ELANE
19ivig459.5TNF, SAG, IFNG, CSF2
20rantes459.5CSF2, IFNG, TNF
21cyclosporin a45 29 6011.5HMGB1, ELANE, SAG, IFNG
22polymyxin b459.5IL8, IFNG, TNF, DEFB1
23n-formylmethionyl-leucylphenylalanine459.5CSF2, ELANE, IL8, TNF
24il-12459.5TNF, IL8, CSF2, IFNG
25imiquimod45 29 60 1112.5IFNG, TNF, CSF2, IL8
26budesonide45 50 1111.5IFNG, CSF2, TNF, IL8
27anaphylatoxin459.5CSF2, IL8, HMGB1, ELANE
28taurine chloramine459.5TNF, IL8, F5, IFNG
29poly(i-c)459.5IFNG, CSF2, TNF, IL8
30il 10459.5TNF, IL8, IFNG, CSF2
31tarc459.4TNF, CSF2, IFNG, IL8
32butyrate459.4CSF2, HMGB1
33staurosporin459.3IFNG, TNF, IL8
34triptolide459.3IFNG, TNF, IL8, VEGFA
35aprotinin45 1110.3F5, IL8, PLAT, ELANE
36gabexate mesilate459.3IL8, PLAT, F5, TNF, ELANE
37fluticasone propionate45 50 60 1112.2CSF2, IFNG, TNF, ELANE, IL8
38neopterin459.2TNF, CSF2, IFNG, ELANE, IL8
39thalidomide45 50 60 1112.1VEGFA, CSF2, IFNG, TNF
40leukotriene b445 60 2411.1CSF2, IL8, TNF, ELANE
41carboplatin45 50 1111.1CSF2, VEGFA, HMGB1, IFNG
4215-deoxy-delta-12,14-prostaglandin j2459.0IL8, VEGFA, TNF, CSF2, IFNG
43heparin45 29 11 2412.0IL8, ELANE, VEGFA, CSF2, HMGB1
44prostacyclin459.0ELANE, TNF, PLAT, F5, VEGFA
45serine458.9HMGB1, LACTB, CCNE1, TNF, IL8
46simvastatin45 50 60 29 11 2413.7PLAT, F5, IL8, VEGFA, IFNG, TNF
47actinomycin d458.7IFNG, VEGFA, IL8, PLAT, CSF2, TNF
48lactate458.6ELANE, HMGB1, CSF2, TNF, F5, IL8
49sb 20358045 609.5CSF2, HMGB1, IL8, VEGFA, TNF, IFNG
50retinoic acid45 249.1CSF2, HMGB1, PLAT, DEFB1, TNF, F5

GO Terms for genes affiliated with Endophthalmitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4ELANE, PLAT, VEGFA
2cell surfaceGO:0099868.2TNF, VEGFA, PLAT, HMGB1, ELANE
3extracellular spaceGO:0056157.4IFNG, CSF2, TNF, F5, VEGFA, IL8
4extracellular regionGO:0055766.8ELANE, IFNG, CSF2, TNF, F5, PRF1

Biological processes related to Endophthalmitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:03274710.0CSF2, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.9TNF, IFNG
3positive regulation of podosome assemblyGO:0718039.9CSF2, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IFNG, TNF
5positive regulation of interleukin-8 biosynthetic processGO:0454169.8TNF, ELANE
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG
7negative regulation of growth of symbiont in hostGO:0441309.6ELANE, TNF, IFNG
8positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, TNF
9cellular response to lipopolysaccharideGO:0712229.6IL8, CSF2, IFNG
10positive regulation of MAP kinase activityGO:0434069.5ELANE, VEGFA, TNF
11positive regulation of protein complex assemblyGO:0313349.3VEGFA, TNF

Molecular functions related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.4HMGB1, VEGFA, TNF, CSF2, IFNG

Products for genes affiliated with Endophthalmitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endophthalmitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet