MCID: END047
MIFTS: 56

Endophthalmitis malady

Eye diseases category

Summaries for Endophthalmitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Endophthalmitis is an inflammation of the internal coats of the eye. It is a possible complication of... more...

MalaCards: Endophthalmitis is related to pneumonia and retinitis. An important gene associated with Endophthalmitis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rheumatoid arthritis and Downstream signaling in naive CD8+ T cells. The compounds rolipram and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related mouse phenotypes are integument and tumorigenesis.

Disease Ontology:8 A globe disease that is characterized by inflammation of the inside of the eye.

Aliases & Classifications for Endophthalmitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

endophthalmitis 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:4692
NCIt39 C34586
MeSH34 D009877
MESH via Orphanet35 D009877
ICD10 via Orphanet26 H44.0, H44.1
SNOMED-CT via Orphanet57 1847009
UMLS via Orphanet61 C0014236
ICD1025 H45.1

Related Diseases for Endophthalmitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Endophthalmitis family:

Acute Endophthalmitis Chronic Endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 244)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.7CSF2, TNF, PRF1, DEFB1, IL8, HMGB1
2retinitis30.6SAG
3meningitis30.5PRF1, IL8, LACTB
4uveitis30.5TNF, SAG, IFNG
5endocarditis30.2NPL, PRF1, LACTB
6retinal vasculitis30.2SAG
7vasculitis30.2ELANE, TNF, SAG
8acute leukemia30.1LACTB, CSF2
9retinal detachment30.1PLAT, VEGFA
10leukemia30.1IFNG, CSF2, TNF, HMGB1, LACTB
11herpes simplex30.0HMGB1
12aspergillosis29.9ELANE, IFNG
13acquired immunodeficiency syndrome29.7CSF2
14pyelonephritis29.7LACTB
15retinoblastoma29.7HMGB1, SAG, CCNE1
16interstitial lung disease29.7TNF
17crohn's disease29.7TNF
18influenza29.7LACTB, IFNG
19neutropenia29.7CSF2, LACTB, ELANE
20bronchiectasis29.7IL8, ELANE
21central retinal artery occlusion29.7PLAT
22disseminated intravascular coagulation29.7F5, PLAT, ELANE
23age related macular degeneration29.7PLAT, VEGFA
24graft versus host disease29.7TNF, CSF2, IFNG
25tuberculosis29.7IFNG, SAG, TNF, PRF1, LACTB
26arthritis29.7IFNG, CSF2, TNF, IL8, HMGB1, LACTB
27cataract10.8
28acute endophthalmitis10.8
29chronic endophthalmitis10.6
30keratitis10.4
31glaucoma10.4
32cellulitis10.3
33orbital cellulitis10.3
34sympathetic ophthalmia10.3
35hypopyon10.3
36corneal ulcer10.3
37purulent endophthalmitis10.3
38acne10.2
39scleritis10.2
40phakoanaphylactic uveitis10.2
41bacterial meningitis10.1
42fusariosis10.0
43posterior uveitis10.0
44candidiasis10.0
45cholecystitis10.0
46chorioretinitis10.0
47conjunctivitis10.0
48factitious disorder10.0
49iridocyclitis10.0
50pterygium10.0

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to endophthalmitis

Clinical Features for Endophthalmitis

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Drugs & Therapeutics for Endophthalmitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Endophthalmitis

Drug clinical trials:

Search ClinicalTrials for Endophthalmitis

Search NIH Clinical Center for Endophthalmitis

Search CenterWatch for Endophthalmitis

Genetic Tests for Endophthalmitis

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Anatomical Context for Endophthalmitis

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32MalaCards
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MalaCards organs/tissues related to Endophthalmitis:

32
Eye, Endothelial, Liver, Retina, Lung, Testes, Brain, Cortex

Animal Models for Endophthalmitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Endophthalmitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.7CCNE1, PRF1, VEGFA
2MP:00020069.4CCNE1, IFNG, TNF, ELANE
3MP:00053919.1SAG, CRYGS, PLAT, HMGB1
4MP:00053768.7NPL, F5, PRF1, PLAT, ELANE, IFNG
5MP:00053977.7CCNE1, IFNG, CSF2, TNF, PRF1, VEGFA
6MP:00053877.3ELANE, CCNE1, IFNG, CSF2, TNF, NPL
7MP:00053867.1CCNE1, IFNG, CSF2, TNF, F5, PRF1
8MP:00107686.9CCNE1, IFNG, CSF2, TNF, F5, PRF1

Publications for Endophthalmitis

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Sources:
50PubMed
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Articles related to Endophthalmitis:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors. (24420916)
2014
2
ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION: Decreasing Incidence and Clinical Outcome-8-year Results from a Tertiary Ophthalmic Referral Center. (24136408)
2013
3
Streptococcus endophthalmitis outbreak after intravitreal injection of bevacizumab: one-year outcomes and investigative results. (23453511)
2013
4
Vancomycin-resistant Staphylococcus hominis endophthalmitis following cataract surgery. (23818754)
2013
5
Endogenous fungal endophthalmitis: risk factors, clinical features, and treatment outcomes in mold and yeast infections. (24053550)
2013
6
Streptococcal endophthalmitis in pediatric keratoprosthesis. (23823506)
2013
7
Non-infectious endophthalmitis after vitrectomy. (23595373)
2013
8
Re: Factors determining visual outcome in endogenous Candida endophthalmitis. (23314237)
2013
9
Intravitreal injections at the Massachusetts Eye and Ear Infirmary: analysis of treatment indications and postinjection endophthalmitis rates. (23390167)
2013
10
Correlation between baseline echographic features of endophthalmitis, microbiological isolates, and visual outcomes. (23637520)
2013
11
Aspergillus Tubingenesis Endophthalmitis after Cataract Surgery with Implantation of Preloaded Intraocular Lens. (24175647)
2013
12
Associated factors and treatment outcome of presumed noninfectious endophthalmitis occurring after intravitreal triamcinolone acetonide injection. (22820815)
2013
13
Review of endogenous endophthalmitis during pregnancy including case series. (23263732)
2013
14
Endophthalmitis is not a "never event". (22858024)
2012
15
Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA. (22527320)
2012
16
Surveillance of late-onset bleb leak, blebitis and bleb-related endophthalmitis--a UK incidence study. (22249317)
2012
17
Scedosporium apiospermum endophthalmitis: diffusion-weighted imaging in detecting subchoroidal abscess. (23204835)
2012
18
A Case of Delayed-Onset Propionibacterium acnes Endophthalmitis after Cataract Surgery with Implantation of a Preloaded Intraocular Lens. (23275791)
2012
19
Coccidioidal endophthalmitis in immunocompetent person, California, USA. (22608196)
2012
20
A case of postoperative endophthalmitis by extended-spectrum beta-lactamase-producing Escherichia coli. (22870032)
2012
21
Quinupristin/dalfopristin in vancomycin-resistant Staphylococcus aureus endophthalmitis. (23044949)
2012
22
Curvularia endophthalmitis following open globe injuries. (22652854)
2012
23
Evolving fluoroquinolone resistance among coagulase-negative Staphylococcus isolates causing endophthalmitis. (23229711)
2012
24
Delayed-Onset Post-Keratoplasty Endophthalmitis Caused by Vancomycin-Resistant Enterococcus faecium. (23185179)
2012
25
Characteristics of endophthalmitis in patients with the Boston keratoprosthesis. (22543518)
2012
26
Outcome of endophthalmitis treatment in a tertiary referral center in southern iran. (22346124)
2012
27
Endogenous Candida albicans endophthalmitis following spontaneous abortion and IUD removal. (22165949)
2011
28
Concurrent endophthalmitis and orbital cellulitis in a child with congenital glaucoma and a glaucoma drainage device. (23362400)
2011
29
Postoperative nosocomial endophthalmitis: is perioperative antibiotic prophylaxis advisable? A single centre's experience. (21450368)
2011
30
Isolated Nocardia exalbida endogenous endophthalmitis. (21770800)
2011
31
Nosocomial acute-onset postoperative endophthalmitis at a university teaching hospital (2002-2009). (20619391)
2010
32
Chronic coccidioidomycosis endophthalmitis without concomitant systemic involvement: a clinicopathological case report. (20471688)
2010
33
Multicenter survey with a systematic overview of acute-onset endophthalmitis after transconjunctival microincision vitrectomy surgery. (20719299)
2010
34
Assessment of sodium hyaluronate gel as vehicle for intracameral delivery of cefuroxime in endophthalmitis prophylaxis. (20637851)
2010
35
Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim culture. (20537193)
2010
36
Retinal vasculitis as an early sign of bacterial post-operative endophthalmitis. (20203699)
2010
37
Topical antibiotics to reduce the risk of endophthalmitis after intravitreal injection? (20837814)
2010
38
Stenotrophomonas maltophilia endogenous endophthalmitis: clinical presentation, sensitivity spectrum and management. (19429764)
2009
39
Risk factors for acute endophthalmitis after cataract surgery: a population-based study. (19091417)
2009
40
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection. (17277758)
2007
41
Endogenous endophthalmitis and disseminated intravascular coagulation complicating a Klebsiella pneumoniae perirenal abscess in a patient with type 2 diabetes. (15767824)
2005
42
The epidemiology of acute endophthalmitis after cataract surgery in an Asian population. (15051201)
2004
43
Rhizobium (Agrobacterium) radiobacter identified as a cause of chronic endophthalmitis subsequent to cataract extraction. (12904441)
2003
44
Endophthalmitis as a complication of meningococcal meningitis: report of one case. (10910599)
1999
45
Purpura fulminans, metastatic endophthalmitis, and thrombotic thrombocytopenic purpura in an HIV-infected patient. (1518589)
1992
46
Neovascular glaucoma, endophthalmitis and evisceration. (1921722)
1991
47
Endogenous Mycobacterium chelonae endophthalmitis. (2789002)
1989
48
Candida endophthalmitis presenting as bilateral posterior uveitis. (6601191)
1983
49
Endophthalmitis associated with group-B streptococcal meningitis in an infant. (380320)
1979
50
Penicillin in treatment of acute endophthalmitis; report of a case. (20276994)
1946

Genetic Variations for Endophthalmitis

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Expression for genes affiliated with Endophthalmitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endophthalmitis

Search GEO for disease gene expression data for Endophthalmitis.

Pathways for genes affiliated with Endophthalmitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Endophthalmitis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Endophthalmitis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.6ELANE
2ulinastatin4410.5ELANE
3pentoxifylline44 1111.4CSF2, ELANE
4hydrocortisone44 2 59 1113.3ELANE, IL8
5protamine4410.2F5, PLAT
6aebsf4410.2ELANE
7gm-csf44 2811.1TNF, IFNG
8endotoxin4410.1F5, HMGB1
9dexamethasone44 49 28 1113.1DEFB1, VEGFA
10pge24410.0VEGFA, SAG, CSF2
11cilomilast449.8ELANE, IL8, TNF
12mip 1alpha449.7IL8, CSF2, TNF
13vancomycin44 1110.7LACTB, F5, ELANE
14ceftriaxone44 1110.6LACTB, PLAT, F5
15azithromycin44 1110.6IL8, LACTB, CSF2
16gold sodium thiomalate449.6IL8, IFNG, TNF
17ofloxacin44 2 1111.5F5, LACTB, CSF2
18superoxide44 2410.5CSF2, TNF, PRF1, ELANE
19ivig449.5TNF, SAG, IFNG, CSF2
20rantes449.5CSF2, IFNG, TNF
21cyclosporin a44 28 5911.5HMGB1, ELANE, SAG, IFNG
22polymyxin b449.5IL8, IFNG, TNF, DEFB1
23n-formylmethionyl-leucylphenylalanine449.5CSF2, ELANE, IL8, TNF
24il-12449.5TNF, IL8, CSF2, IFNG
25imiquimod44 28 59 1112.5IFNG, TNF, CSF2, IL8
26budesonide44 49 1111.5IFNG, CSF2, TNF, IL8
27anaphylatoxin449.5CSF2, IL8, HMGB1, ELANE
28taurine chloramine449.5TNF, IL8, F5, IFNG
29poly(i-c)449.5IFNG, CSF2, TNF, IL8
30il 10449.5TNF, IL8, IFNG, CSF2
31tarc449.4TNF, CSF2, IFNG, IL8
32butyrate449.4CSF2, HMGB1
33staurosporin449.3IFNG, TNF, IL8
34triptolide449.3IFNG, TNF, IL8, VEGFA
35aprotinin44 1110.3F5, IL8, PLAT, ELANE
36gabexate mesilate449.3IL8, PLAT, F5, TNF, ELANE
37fluticasone propionate44 49 59 1112.2CSF2, IFNG, TNF, ELANE, IL8
38neopterin449.2TNF, CSF2, IFNG, ELANE, IL8
39thalidomide44 49 59 1112.1VEGFA, CSF2, IFNG, TNF
40leukotriene b444 59 2411.1CSF2, IL8, TNF, ELANE
41carboplatin44 49 1111.1CSF2, VEGFA, HMGB1, IFNG
4215-deoxy-delta-12,14-prostaglandin j2449.0IL8, VEGFA, TNF, CSF2, IFNG
43heparin44 28 11 2412.0IL8, ELANE, VEGFA, CSF2, HMGB1
44prostacyclin449.0ELANE, TNF, PLAT, F5, VEGFA
45serine448.9HMGB1, LACTB, CCNE1, TNF, IL8
46simvastatin44 49 59 28 11 2413.7PLAT, F5, IL8, VEGFA, IFNG, TNF
47actinomycin d448.7IFNG, VEGFA, IL8, PLAT, CSF2, TNF
48lactate448.6ELANE, HMGB1, CSF2, TNF, F5, IL8
49sb 20358044 599.5CSF2, HMGB1, IL8, VEGFA, TNF, IFNG
50retinoic acid44 249.1CSF2, HMGB1, PLAT, DEFB1, TNF, F5

GO Terms for genes affiliated with Endophthalmitis

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16Gene Ontology
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Cellular components related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4ELANE, PLAT, VEGFA
2cell surfaceGO:0099868.2TNF, VEGFA, PLAT, HMGB1, ELANE
3extracellular spaceGO:0056157.4IFNG, CSF2, TNF, F5, VEGFA, IL8
4extracellular regionGO:0055766.8ELANE, IFNG, CSF2, TNF, F5, PRF1

Biological processes related to Endophthalmitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:03274710.0CSF2, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.9TNF, IFNG
3positive regulation of podosome assemblyGO:0718039.9CSF2, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IFNG, TNF
5positive regulation of interleukin-8 biosynthetic processGO:0454169.8TNF, ELANE
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG
7negative regulation of growth of symbiont in hostGO:0441309.6ELANE, TNF, IFNG
8positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, TNF
9cellular response to lipopolysaccharideGO:0712229.6IL8, CSF2, IFNG
10positive regulation of MAP kinase activityGO:0434069.5ELANE, VEGFA, TNF
11positive regulation of protein complex assemblyGO:0313349.3VEGFA, TNF

Molecular functions related to Endophthalmitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.4HMGB1, VEGFA, TNF, CSF2, IFNG

Products for genes affiliated with Endophthalmitis

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  • Antibodies
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Sources for Endophthalmitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet