MCID: END072
MIFTS: 42

Endotheliitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

Aliases & Descriptions for Endotheliitis:

Name: Endotheliitis 56

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA137602

Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to coarctation of aorta and fuchs' endothelial dystrophy. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Ganciclovir and Ganciclovir triphosphate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, monocytes and brain, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 71 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 965)
id Related Disease Score Top Affiliating Genes
1 coarctation of aorta 28.2 CXCL10 CXCL11 CXCL9
2 fuchs' endothelial dystrophy 12.4
3 corneal endothelial dystrophy 2, autosomal recessive 12.2
4 corneal endothelial dystrophy 12.1
5 intravascular papillary endothelial hyperplasia 12.1
6 corneal dystrophy, fuchs endothelial, 1 12.1
7 corneal dystrophy, fuchs endothelial, 3 12.1
8 iridocorneal endothelial syndrome 12.1
9 corneal endothelial dystrophy 1, autosomal dominant 12.1
10 corneal dystrophy, fuchs endothelial, 4 12.1
11 corneal dystrophy, fuchs endothelial, 6 12.1
12 corneal dystrophy, fuchs endothelial, 8 12.0
13 corneal dystrophy, fuchs endothelial, 2 12.0
14 corneal dystrophy, fuchs endothelial, 5 11.9
15 corneal dystrophy, endothelial, x-linked 11.9
16 corneal endothelial dystrophy type 2 11.8
17 corneal endothelial dystrophy and perceptive deafness 11.8
18 corneal dystrophy, fuchs endothelial, 7 11.7
19 corneal dystrophy, posterior polymorphous, 1 11.6
20 edict syndrome 11.5
21 hemangioma 11.1
22 spotted fever 11.1
23 lymphangiosarcoma 11.1
24 bullous keratopathy 11.0
25 hemolytic-uremic syndrome 11.0
26 capillary leak syndrome 11.0
27 alzheimer disease 10.9
28 aneurysmal bone cysts 10.9
29 macular corneal dystrophy 10.9
30 heme oxygenase-1 deficiency 10.9
31 essential iris atrophy 10.9
32 capillary malformations, congenital, 1, somatic, mosaic 10.9
33 corneal dystrophy, congenital stromal 10.8
34 hemangioma, capillary infantile 10.8
35 lung cancer 10.8
36 pulmonary hypertension, familial primary, 1, with or without hht 10.6
37 cerebral cavernous malformations-1 10.6
38 gaucher disease, type i 10.6
39 plasminogen activator inhibitor-1 deficiency 10.6
40 cogan-reese syndrome 10.6
41 pulmonary hypertension, primary, 3 10.6
42 venous malformations, multiple cutaneous and mucosal 10.6
43 high molecular weight kininogen deficiency 10.6
44 capillary disease 10.6
45 pulmonary hypertension, primary, 4 10.6
46 carrion's disease 10.6
47 pulmonary hypertension, primary, 2 10.6
48 hypoxia 10.5
49 neuroblastoma 10.4
50 breast cancer 10.4

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis

Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.32 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 CXCL11 CXCL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.32 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 CXCL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.32 CXCL11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CXCL11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.32 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 CXCL10

Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
2 Ganciclovir triphosphate Phase 4
3 Nucleic Acid Synthesis Inhibitors Phase 4
4 Anti-Infective Agents Phase 4
5 Antiviral Agents Phase 4
6 Tetrahydrozoline Phase 4
7 Ophthalmic Solutions Phase 4
8 Pharmaceutical Solutions Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4
2 Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis Unknown status NCT01359995
3 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

39
Endothelial, Monocytes, Brain, Lung, Breast, Neutrophil, Smooth Muscle

Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 25652)
id Title Authors Year
1
WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis. ( 28465477 )
2017
2
Vascular endothelial growth factor levels in patients with obstructive sleep apnea: a meta-analysis. ( 27236786 )
2017
3
The functional variants of endothelial nitric oxide synthase gene associated with rheumatoid arthritis in Turkish adults. ( 27695991 )
2017
4
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia. ( 27901381 )
2017
5
Dysregulation of Vascular Endothelial Growth Factor Receptor-2 by Multiple miRNAs in Endothelial Colony-Forming Cells of Coronary Artery Disease. ( 28122380 )
2017
6
Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer. ( 28088809 )
2017
7
MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. ( 28110404 )
2017
8
Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases. ( 28290616 )
2017
9
Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma. ( 28122267 )
2017
10
Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma. ( 27577989 )
2017
11
Interleukin-6 trans-signalling induces vascular endothelial growth factor synthesis partly via Janus kinases-STAT3 pathway in human mesothelial cells. ( 26869278 )
2017
12
Sargachromenol protects against vascular inflammation by preventing TNF-I+-induced monocyte adhesion to primary endothelial cells via inhibition of NF-I_B activation. ( 27902962 )
2017
13
Platelets modulate endothelial cell response to dynamic shear stress through PECAM-1. ( 28013181 )
2017
14
PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186. ( 28351322 )
2017
15
Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. ( 28218663 )
2017
16
Association of -460C/T and +405 G/C polymorphisms of vascular endothelial growth factor gene and susceptibility to ovarian hyperstimulation syndrome. ( 28462400 )
2017
17
Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. ( 28087315 )
2017
18
The impact of the endothelial protein C receptor on thrombin generation and clot lysis. ( 28219843 )
2017
19
Endothelial progenitor cell number is not decreased in 34 children with Juvenile Dermatomyositis: a pilot study. ( 28514969 )
2017
20
Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1I+ and vascular endothelial growth factor. ( 28091613 )
2017
21
Patients With Dry Eye Disease and Low Subbasal Nerve Density Are at High Risk for Accelerated Corneal Endothelial Cell Loss. ( 28060067 )
2017
22
Intravascular Papillary Endothelial Hyperplasia at Foot Level: A Case Report and Literature Review. ( 27989349 )
2017
23
SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. ( 28122311 )
2017
24
Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function. ( 27995357 )
2017
25
Vascular endothelial growth factor antagonist reduces the early onset and the severity of ovarian hyperstimulation syndrome. ( 28403961 )
2017
26
Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling. ( 28153047 )
2017
27
Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway. ( 27914823 )
2017
28
A simple method to induce hypoxia-induced vascular endothelial growth factor-A (VEGF-A) expression in T24 human bladder cancer cells. ( 27752923 )
2017
29
Endothelial function impairment in STEMI patients with out-of-hospital cardiac arrest under therapeutic hypothermia treatment. ( 28087172 )
2017
30
Cables1 Inhibits Proliferation and Induces Senescence by Angiotensin II via a p21-Dependent Pathway in Human Umbilical Vein Endothelial Cells. ( 28118639 )
2017
31
Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro. ( 28150318 )
2017
32
Colorectal polypoid lesions and expression of vascular endothelial growth factor in a consecutive series of endoscopic and surgical patients. ( 28347226 )
2017
33
Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway. ( 28116308 )
2017
34
Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy. ( 27580405 )
2017
35
The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. ( 28216678 )
2017
36
Reported Prestroke Physical Activity Is Associated with Vascular Endothelial Growth Factor Expression and Good Outcomes after Stroke. ( 28029607 )
2017
37
Re: Endothelial dysfunction and vascular stiffness in women with previous pregnancy complicated by early or late pre-eclampsia. R. Orabona, E. Sciatti, E. Vizzardi, I. Bonadei and A. Valcamonico. Ultrasound Obstet Gynecol 2017; 49: 116-123. ( 28058790 )
2017
38
Soluble endoglin modulates the pro-inflammatory mediators NF-I_B and IL-6 in cultured human endothelial cells. ( 28336397 )
2017
39
Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2. ( 27889230 )
2017
40
C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway. ( 27734226 )
2017
41
Depleted nitric oxide and prostaglandin E2 levels are correlated with endothelial dysfunction in I^-thalassemia/HbE patients. ( 28474291 )
2017
42
Triazole RGD antagonist reverts TGFI^1-induced endothelial-to-mesenchymal transition in endothelial precursor cells. ( 27761847 )
2017
43
Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk. ( 28195197 )
2017
44
Association of a Vascular Endothelial Growth Factor genetic variant with Serum VEGF level in subjects with Metabolic Syndrome. ( 27984191 )
2017
45
Modulation of digital flexor tendon healing by vascular endothelial growth factor gene transfection in a chicken model. ( 28221337 )
2017
46
Endothelial function in children with a history of henoch schonlein purpura. ( 28088210 )
2017
47
Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease. ( 28072843 )
2017
48
Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease. ( 28069066 )
2017
49
Circulating Endothelial Progenitor Cells in Crohn's Disease: An EPiC in the Making? ( 28078527 )
2017
50
Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis. ( 27848074 )
2017

Variations for Endotheliitis

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 CXCL10 CXCL11 CXCL9
2
Show member pathways
12.94 CXCL10 CXCL11 CXCL9
3
Show member pathways
12.79 CXCL10 CXCL11 CXCL9
4
Show member pathways
12.78 CXCL10 CXCL11 CXCL9
5
Show member pathways
12.64 CXCL10 CXCL11 CXCL9
6
Show member pathways
12.32 CXCL10 CXCL11 CXCL9
7
Show member pathways
12.25 CXCL10 CXCL11 CXCL9
8
Show member pathways
11.65 CXCL10 CXCL11
9
Show member pathways
11.22 CXCL10 CXCL11 CXCL9
10 10.82 CXCL10 CXCL9
11 10.56 CXCL10 CXCL11 CXCL9
12 10.33 CXCL10 CXCL11 CXCL9

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CXCL10 CXCL9
2 extracellular space GO:0005615 8.8 CXCL10 CXCL11 CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.73 CXCL10 CXCL11 CXCL9
2 G-protein coupled receptor signaling pathway GO:0007186 9.71 CXCL10 CXCL11 CXCL9
3 immune response GO:0006955 9.7 CXCL10 CXCL11 CXCL9
4 inflammatory response GO:0006954 9.69 CXCL10 CXCL11 CXCL9
5 cell-cell signaling GO:0007267 9.67 CXCL10 CXCL11 CXCL9
6 regulation of cell proliferation GO:0042127 9.65 CXCL10 CXCL11 CXCL9
7 response to lipopolysaccharide GO:0032496 9.61 CXCL10 CXCL11 CXCL9
8 chemotaxis GO:0006935 9.58 CXCL10 CXCL11 CXCL9
9 defense response to virus GO:0051607 9.55 CXCL10 CXCL9
10 defense response GO:0006952 9.54 CXCL10 CXCL11 CXCL9
11 chemokine-mediated signaling pathway GO:0070098 9.5 CXCL10 CXCL11 CXCL9
12 positive regulation of leukocyte chemotaxis GO:0002690 9.46 CXCL11 CXCL9
13 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.43 CXCL10 CXCL11 CXCL9
14 positive regulation of cAMP-mediated signaling GO:0043950 9.33 CXCL10 CXCL11 CXCL9
15 T cell chemotaxis GO:0010818 9.13 CXCL10 CXCL11 CXCL9
16 positive regulation of cAMP metabolic process GO:0030816 8.8 CXCL10 CXCL11 CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CXCL10 CXCL11 CXCL9
2 heparin binding GO:0008201 9.26 CXCL10 CXCL11
3 chemokine activity GO:0008009 9.13 CXCL10 CXCL11 CXCL9
4 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL10 CXCL11 CXCL9

Sources for Endotheliitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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