MCID: END072
MIFTS: 42

Endotheliitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

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Aliases & Descriptions for Endotheliitis:

Name: Endotheliitis 54

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Orphanet54 ORPHA137602

Summaries for Endotheliitis

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Wikipedia:71 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards based summary: Endotheliitis is related to coarctation of aorta and fuchs' endothelial dystrophy. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways are Type II interferon signaling (IFNG) and Bacterial infections in CF airways. Affiliated tissues include endothelial, monocytes and brain, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Endotheliitis

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Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 965)
idRelated DiseaseScoreTop Affiliating Genes
1coarctation of aorta28.2CXCL10, CXCL11, CXCL9
2fuchs' endothelial dystrophy12.4
3corneal endothelial dystrophy 2, autosomal recessive12.2
4corneal endothelial dystrophy12.1
5intravascular papillary endothelial hyperplasia12.1
6corneal dystrophy, fuchs endothelial, 112.1
7corneal dystrophy, fuchs endothelial, 312.1
8iridocorneal endothelial syndrome12.1
9corneal endothelial dystrophy 1, autosomal dominant12.1
10corneal dystrophy, fuchs endothelial, 612.1
11corneal dystrophy, fuchs endothelial, 412.1
12corneal dystrophy, fuchs endothelial, 812.0
13corneal dystrophy, fuchs endothelial, 212.0
14corneal dystrophy, fuchs endothelial, 511.9
15corneal dystrophy, endothelial, x-linked11.9
16corneal endothelial dystrophy type 211.8
17corneal endothelial dystrophy and perceptive deafness11.8
18corneal dystrophy, fuchs endothelial, 711.7
19corneal dystrophy, posterior polymorphous, 111.6
20edict syndrome11.5
21hemangioma11.1
22spotted fever11.1
23lymphangiosarcoma11.1
24bullous keratopathy11.0
25hemolytic-uremic syndrome11.0
26capillary leak syndrome11.0
27alzheimer disease10.9
28aneurysmal bone cysts10.9
29macular corneal dystrophy10.9
30heme oxygenase-1 deficiency10.9
31essential iris atrophy10.9
32capillary malformations, congenital, 1, somatic, mosaic10.9
33hemangioma, capillary infantile10.8
34corneal dystrophy, congenital stromal10.8
35lung cancer10.8
36gaucher disease, type i10.6
37pulmonary hypertension, primary, 410.6
38pulmonary hypertension, familial primary, 1, with or without hht10.6
39cerebral cavernous malformations-110.6
40plasminogen activator inhibitor-1 deficiency10.6
41pulmonary hypertension, primary, 310.6
42venous malformations, multiple cutaneous and mucosal10.6
43pulmonary hypertension, primary, 210.6
44high molecular weight kininogen deficiency10.6
45carrion's disease10.6
46cogan-reese syndrome10.6
47capillary disease10.6
48hypoxia10.5
49neuroblastoma10.4
50breast cancer10.4

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Symptoms & Phenotypes for Endotheliitis

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GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.0CXCL10, CXCL11

Drugs & Therapeutics for Endotheliitis

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Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ganciclovirapproved, investigationalPhase 415382410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3
2Nucleic Acid Synthesis InhibitorsPhase 44962
3Anti-Infective AgentsPhase 422062
4Ganciclovir triphosphatePhase 4153
5Antiviral AgentsPhase 49967
6TetrahydrozolinePhase 4621
7Ophthalmic SolutionsPhase 41140
8Pharmaceutical SolutionsPhase 48192

Interventional clinical trials:

idNameStatusNCT IDPhase
1Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / EndotheliitisRecruitingNCT02943057Phase 4
2Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus EndotheliitisUnknown statusNCT01359995
3Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / EndotheliitisCompletedNCT01647529

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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MalaCards organs/tissues related to Endotheliitis:

36
Endothelial, Monocytes, Brain, Lung, Breast, Neutrophil, Smooth muscle

Publications for Endotheliitis

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Articles related to Endotheliitis:

(show top 50)    (show all 25652)
idTitleAuthorsYear
1
WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis. (28465477)
2017
2
Vascular endothelial growth factor levels in patients with obstructive sleep apnea: a meta-analysis. (27236786)
2017
3
The functional variants of endothelial nitric oxide synthase gene associated with rheumatoid arthritis in Turkish adults. (27695991)
2017
4
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia. (27901381)
2017
5
Dysregulation of Vascular Endothelial Growth Factor Receptor-2 by Multiple miRNAs in Endothelial Colony-Forming Cells of Coronary Artery Disease. (28122380)
2017
6
Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer. (28088809)
2017
7
MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. (28110404)
2017
8
Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases. (28290616)
2017
9
Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma. (28122267)
2017
10
Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma. (27577989)
2017
11
Interleukin-6 trans-signalling induces vascular endothelial growth factor synthesis partly via Janus kinases-STAT3 pathway in human mesothelial cells. (26869278)
2017
12
Sargachromenol protects against vascular inflammation by preventing TNF-I+-induced monocyte adhesion to primary endothelial cells via inhibition of NF-I_B activation. (27902962)
2017
13
Platelets modulate endothelial cell response to dynamic shear stress through PECAM-1. (28013181)
2017
14
PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186. (28351322)
2017
15
Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. (28218663)
2017
16
Association of -460C/T and +405 G/C polymorphisms of vascular endothelial growth factor gene and susceptibility to ovarian hyperstimulation syndrome. (28462400)
2017
17
Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. (28087315)
2017
18
The impact of the endothelial protein C receptor on thrombin generation and clot lysis. (28219843)
2017
19
Endothelial progenitor cell number is not decreased in 34 children with Juvenile Dermatomyositis: a pilot study. (28514969)
2017
20
Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1I+ and vascular endothelial growth factor. (28091613)
2017
21
Patients With Dry Eye Disease and Low Subbasal Nerve Density Are at High Risk for Accelerated Corneal Endothelial Cell Loss. (28060067)
2017
22
Intravascular Papillary Endothelial Hyperplasia at Foot Level: A Case Report and Literature Review. (27989349)
2017
23
SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. (28122311)
2017
24
Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function. (27995357)
2017
25
Vascular endothelial growth factor antagonist reduces the early onset and the severity of ovarian hyperstimulation syndrome. (28403961)
2017
26
Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling. (28153047)
2017
27
Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway. (27914823)
2017
28
A simple method to induce hypoxia-induced vascular endothelial growth factor-A (VEGF-A) expression in T24 human bladder cancer cells. (27752923)
2017
29
Endothelial function impairment in STEMI patients with out-of-hospital cardiac arrest under therapeutic hypothermia treatment. (28087172)
2017
30
Cables1 Inhibits Proliferation and Induces Senescence by Angiotensin II via a p21-Dependent Pathway in Human Umbilical Vein Endothelial Cells. (28118639)
2017
31
Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro. (28150318)
2017
32
Colorectal polypoid lesions and expression of vascular endothelial growth factor in a consecutive series of endoscopic and surgical patients. (28347226)
2017
33
Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway. (28116308)
2017
34
Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy. (27580405)
2017
35
The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. (28216678)
2017
36
Reported Prestroke Physical Activity Is Associated with Vascular Endothelial Growth Factor Expression and Good Outcomes after Stroke. (28029607)
2017
37
Re: Endothelial dysfunction and vascular stiffness in women with previous pregnancy complicated by early or late pre-eclampsia. R. Orabona, E. Sciatti, E. Vizzardi, I. Bonadei and A. Valcamonico. Ultrasound Obstet Gynecol 2017; 49: 116-123. (28058790)
2017
38
Soluble endoglin modulates the pro-inflammatory mediators NF-I_B and IL-6 in cultured human endothelial cells. (28336397)
2017
39
Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2. (27889230)
2017
40
C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway. (27734226)
2017
41
Depleted nitric oxide and prostaglandin E2 levels are correlated with endothelial dysfunction in I^-thalassemia/HbE patients. (28474291)
2017
42
Triazole RGD antagonist reverts TGFI^1-induced endothelial-to-mesenchymal transition in endothelial precursor cells. (27761847)
2017
43
Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk. (28195197)
2017
44
Association of a Vascular Endothelial Growth Factor genetic variant with Serum VEGF level in subjects with Metabolic Syndrome. (27984191)
2017
45
Modulation of digital flexor tendon healing by vascular endothelial growth factor gene transfection in a chicken model. (28221337)
2017
46
Endothelial function in children with a history of henoch schonlein purpura. (28088210)
2017
47
Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease. (28072843)
2017
48
Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease. (28069066)
2017
49
Circulating Endothelial Progenitor Cells in Crohn's Disease: An EPiC in the Making? (28078527)
2017
50
Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis. (27848074)
2017

Variations for Endotheliitis

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Expression for genes affiliated with Endotheliitis

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Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

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Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.3CXCL10, CXCL9
2
Show member pathways
9.0CXCL10, CXCL11
3
Show member pathways
8.5CXCL10, CXCL11, CXCL9
4
Show member pathways
8.5CXCL10, CXCL11, CXCL9
5
Show member pathways
8.5CXCL10, CXCL11, CXCL9
6
Show member pathways
8.5CXCL10, CXCL11, CXCL9
7
Show member pathways
8.5CXCL10, CXCL11, CXCL9
8
Show member pathways
8.5CXCL10, CXCL11, CXCL9
98.5CXCL10, CXCL11, CXCL9
10
Show member pathways
8.5CXCL10, CXCL11, CXCL9
118.5CXCL10, CXCL11, CXCL9
12
Show member pathways
8.5CXCL10, CXCL11, CXCL9

GO Terms for genes affiliated with Endotheliitis

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Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:000989710.1CXCL10, CXCL9
2extracellular spaceGO:00056158.5CXCL10, CXCL11, CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:005160710.1CXCL10, CXCL9
2positive regulation of leukocyte chemotaxisGO:00026909.9CXCL11, CXCL9
3cell-cell signalingGO:00072679.3CXCL10, CXCL11, CXCL9
4chemokine-mediated signaling pathwayGO:00700989.3CXCL10, CXCL11, CXCL9
5chemotaxisGO:00069359.3CXCL10, CXCL11, CXCL9
6defense responseGO:00069529.3CXCL10, CXCL11, CXCL9
7G-protein coupled receptor signaling pathwayGO:00071869.3CXCL10, CXCL11, CXCL9
8immune responseGO:00069559.3CXCL10, CXCL11, CXCL9
9inflammatory responseGO:00069549.3CXCL10, CXCL11, CXCL9
10positive regulation of cAMP metabolic processGO:00308169.3CXCL10, CXCL11, CXCL9
11positive regulation of cAMP-mediated signalingGO:00439509.3CXCL10, CXCL11, CXCL9
12positive regulation of release of sequestered calcium ion into cytosolGO:00512819.3CXCL10, CXCL11, CXCL9
13regulation of cell proliferationGO:00421279.3CXCL10, CXCL11, CXCL9
14response to lipopolysaccharideGO:00324969.3CXCL10, CXCL11, CXCL9
15signal transductionGO:00071658.7CXCL10, CXCL11, CXCL9
16T cell chemotaxisGO:00108188.5CXCL10, CXCL11, CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.1CXCL10, CXCL11, CXCL9
2CXCR3 chemokine receptor bindingGO:00482489.1CXCL10, CXCL11, CXCL9
3cytokine activityGO:00051259.1CXCL10, CXCL11, CXCL9
4heparin bindingGO:00082019.0CXCL10, CXCL11

Sources for Endotheliitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet