MCID: END072
MIFTS: 41

Endotheliitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

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Aliases & Descriptions for Endotheliitis:

Name: Endotheliitis 51

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Orphanet51 137602

Summaries for Endotheliitis

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Wikipedia:68 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards based summary: Endotheliitis is related to malaria and fuchs' endothelial dystrophy. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways are Type II interferon signaling (IFNG) and Bacterial infections in CF airways. Affiliated tissues include breast, endothelial and lung.

Related Diseases for Endotheliitis

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Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 3321)
idRelated DiseaseScoreTop Affiliating Genes
1malaria29.1CXCL10, CXCL11, CXCL9
2fuchs' endothelial dystrophy12.6
3corneal endothelial dystrophy 2, autosomal recessive12.5
4corneal dystrophy, fuchs endothelial, 112.5
5corneal dystrophy, fuchs endothelial, 312.5
6corneal dystrophy, fuchs endothelial, 612.5
7corneal dystrophy, fuchs endothelial, 412.5
8iridocorneal endothelial syndrome12.5
9corneal dystrophy, fuchs endothelial, 812.4
10intravascular papillary endothelial hyperplasia12.4
11corneal dystrophy, fuchs endothelial, 212.4
12corneal dystrophy, fuchs endothelial, 512.4
13corneal endothelial dystrophy 1, autosomal dominant12.4
14corneal dystrophy, endothelial, x-linked12.3
15corneal endothelial dystrophy type 212.3
16congenital hereditary endothelial dystrophy type ii12.3
17congenital hereditary endothelial dystrophy type i12.3
18corneal endothelial dystrophy and perceptive deafness12.3
19corneal dystrophy, fuchs endothelial, 712.2
20endothelial dystrophy12.2
21chandler syndrome11.8
22edict syndrome11.6
23lung cancer11.1
24neuroblastoma11.0
25rheumatoid arthritis11.0
26colorectal cancer10.9
27hiv-110.9
28hemangioma10.8
29osteoarthritis10.8
30hepatosplenic t-cell lymphoma10.7
31spotted fever10.7
32polycystic kidney disease10.7
33lymphangiosarcoma10.7
34alzheimer disease10.7
35alcoholic hepatitis10.7
36typhus10.6
37hemolytic-uremic syndrome10.6
38h. pylori infection10.6
39angiosarcoma10.6
40breast cancer10.6
41hepatitis10.6
42lung cancer susceptibility 310.6
43leukemia10.6
44bullous keratopathy10.6
45lymphoma10.5
46prostatitis10.5
47macular corneal dystrophy10.5
48aneurysmal bone cysts10.5
49capillary leak syndrome10.5
50neuronitis10.5

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Symptoms for Endotheliitis

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Drugs & Therapeutics for Endotheliitis

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Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ganciclovirapproved, investigational14082410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene IV
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir Sodium
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3
2Nucleic Acid Synthesis Inhibitors3836
3Ganciclovir triphosphate140
4Anti-Infective Agents17220
5Antiviral Agents8071

Interventional clinical trials:

idNameStatusNCT IDPhase
1Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / EndotheliitisCompletedNCT01647529
2Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus EndotheliitisRecruitingNCT01359995

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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MalaCards organs/tissues related to Endotheliitis:

33
Breast, Endothelial, Lung, T cells, Liver, Brain, Bone

Animal Models for Endotheliitis or affiliated genes

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MGI Mouse Phenotypes related to Endotheliitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Endotheliitis

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Articles related to Endotheliitis:

(show top 50)    (show all 24499)
idTitleAuthorsYear
1
Effect of psychosocial stressors on patients with Crohn's disease: threatening life experiences and family relations. (27203602)
2016
2
Spontaneous Bilateral Cervical Internal Carotid and Vertebral Artery Dissection in a Japanese Patient without Collagen Vascular Disease with Special Reference to Single-Nucleotide Polymorphisms. (27216377)
2016
3
Re: Hormone Abnormalities are Not Related to the Erectile Dysfunction and Decreased Libido Found in Many Men with Infertility. (25890560)
2015
4
Genetic Variants in Interleukin-28B Are Associated with Diabetes and Diabetes-Related Complications in Patients with Chronic Hepatitis C Virus Infection. (25663241)
2015
5
Ultra-low dose comprehensive cardiac CT imaging in a patient with acute myocarditis. (25439792)
2014
6
p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. (23785138)
2013
7
Analysis of relative expression level of VEGF ( vascular endothelial growth factor ), HIF-1I+ ( hypoxia inducible factor 1I+ ) and CTGF ( connective tissue growth factor ) genes in chronic glomerulonephritis (CGN) patients. (24577260)
2013
8
Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. (23461656)
2013
9
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy. (23830351)
2013
10
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
11
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBa88 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. (22998838)
2012
12
Mutations in the I^-subunit of rod phosphodiesterase identified in consanguineous Pakistani families with autosomal recessive retinitis pigmentosa. (21655355)
2011
13
Pituitary apoplexy. (21415110)
2011
14
Different effects of enoxaparin, nadroparin, and dalteparin on plasma TFPI during hemodialysis: a prospective crossover randomized study. (20682597)
2011
15
JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells. (20483637)
2010
16
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). (20023287)
2010
17
Holter monitoring in 36 dogs with myxomatous mitral valve disease. (20854294)
2010
18
The association between adjustment disorder diagnosed at psychiatric treatment facilities and completed suicide. (20865099)
2010
19
Molecular basis of severe myoclonic epilepsy in infancy. (19203854)
2009
20
Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1. (19589865)
2009
21
Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus. (18240214)
2008
22
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
23
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (17916749)
2008
24
Microalbuminuria in children with vesicoureteral reflux. (18661415)
2008
25
Identification of the repeated number of C and D regions of tyrosine phosphorylation motifs in Helicobacter pylori cagA using multiplex PCR. (18822081)
2008
26
A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. (18367606)
2008
27
Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication. (18341639)
2008
28
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. (17344917)
2007
29
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
30
On call. Last month I developed severe weakness on the whole left side of my face. My doctor diagnosed Bell's palsy and referred me to a neurologist. I recovered before I got to see her, so I didn't keep the appointment. Although my face is now back to normal, I'd like to know more about the condition. What can you tell me? (17278299)
2006
31
Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. (16474401)
2006
32
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. (17154495)
2006
33
Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients. (16101187)
2005
34
Bilateral surgically induced necrotising scleritis with secondary superinfection. (15615764)
2005
35
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
36
Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men. (12759156)
2003
37
Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia. (12928232)
2003
38
Non-puerperal uterine inversion associated with an atypical leiomyoma. (11284635)
2001
39
Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis. (11358378)
2001
40
Plasma cholesteryl ester transfer protein and lipoprotein levels during treatment of growth hormone-deficient adult humans. (11485157)
2001
41
Phenotypic and molecular diversity of haemoglobin H disease: a Greek experience. (11122156)
2000
42
TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization. (10407185)
1999
43
Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Ribavirin Study Group. (10723500)
1999
44
Human ehrlichiosis--Maryland, 1994. (8926996)
1996
45
Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. (7628841)
1995
46
Serum hepatocyte growth factor levels in patients with chronic renal failure. (7477621)
1995
47
Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro. (8045498)
1994
48
The -158 (C-->T) promoter mutation is responsible for the increased transcription of the 3' gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin. (7514907)
1994
49
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1955512)
1991
50
Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase. (3143729)
1988

Variations for Endotheliitis

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Expression for genes affiliated with Endotheliitis

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Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

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Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.3CXCL10, CXCL9
2
Show member pathways
9.0CXCL10, CXCL11
3
Show member pathways
8.5CXCL10, CXCL11, CXCL9
4
Show member pathways
8.5CXCL10, CXCL11, CXCL9
5
Show member pathways
8.5CXCL10, CXCL11, CXCL9
6
Show member pathways
8.5CXCL10, CXCL11, CXCL9
7
Show member pathways
8.5CXCL10, CXCL11, CXCL9
8
Show member pathways
8.5CXCL10, CXCL11, CXCL9
9
Show member pathways
8.5CXCL10, CXCL11, CXCL9
10
Show member pathways
8.5CXCL10, CXCL11, CXCL9
118.5CXCL10, CXCL11, CXCL9

GO Terms for genes affiliated with Endotheliitis

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Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00069549.6CXCL10, CXCL9
2positive regulation of leukocyte chemotaxisGO:00026909.5CXCL11, CXCL9
3T cell chemotaxisGO:00108189.4CXCL10, CXCL11
4defense response to virusGO:00516079.2CXCL10, CXCL9
5cell-cell signalingGO:00072678.8CXCL10, CXCL11, CXCL9
6positive regulation of cAMP-mediated signalingGO:00439508.8CXCL10, CXCL11, CXCL9
7chemotaxisGO:00069358.7CXCL10, CXCL11, CXCL9
8immune responseGO:00069558.7CXCL10, CXCL11, CXCL9
9response to lipopolysaccharideGO:00324968.5CXCL10, CXCL11, CXCL9
10signal transductionGO:00071658.5CXCL10, CXCL11, CXCL9
11G-protein coupled receptor signaling pathwayGO:00071868.2CXCL10, CXCL11, CXCL9

Sources for Endotheliitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet