MCID: END072
MIFTS: 46

Endotheliitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis 55

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 55  
Rare eye diseases


External Ids:

Orphanet 55 ORPHA137602

Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to carrion's disease and psoriasis. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Ganciclovir and Ganciclovir triphosphate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, monocytes and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Endotheliitis is an immune response withinendothelium in blood vessels, in which they become inflamed.... more...

Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1210)
# Related Disease Score Top Affiliating Genes
1 carrion's disease 30.9 CXCL10 CXCL9
2 psoriasis 29.2 CXCL10 CXCL9
3 encephalitis 29.1 CXCL10 CXCL9
4 alopecia areata 28.9 CXCL10 CXCL9
5 pulmonary fibrosis, idiopathic 28.9 CXCL10 CXCL9
6 multiple sclerosis 28.8 CXCL10 CXCL11 CXCL9
7 cryoglobulinemia 28.7 CXCL10 CXCL11
8 mycobacterium tuberculosis 1 28.4 CXCL10 CXCL9
9 mycosis fungoides 28.2 CXCL10 CXCL11 CXCL9
10 fuchs' endothelial dystrophy 12.5
11 corneal endothelial dystrophy 12.5
12 corneal dystrophy, fuchs endothelial, 1 12.4
13 corneal endothelial dystrophy type 2 12.3
14 intravascular papillary endothelial hyperplasia 12.3
15 corneal dystrophy, fuchs endothelial, 3 12.2
16 corneal dystrophy, fuchs endothelial, 4 12.2
17 corneal dystrophy, fuchs endothelial, 6 12.2
18 iridocorneal endothelial syndrome 12.2
19 corneal dystrophy, fuchs endothelial, 2 12.2
20 corneal dystrophy, fuchs endothelial, 8 12.1
21 corneal dystrophy, fuchs endothelial, 5 12.1
22 corneal dystrophy, endothelial, x-linked 12.1
23 congenital hereditary endothelial dystrophy type i 12.0
24 corneal dystrophy, posterior polymorphous, 1 11.9
25 corneal dystrophy, fuchs endothelial, 7 11.9
26 endothelial dystrophy, congenital hereditary, with nail hypoplasia 11.8
27 edict syndrome 11.7
28 corneal dystrophy and perceptive deafness 11.5
29 spotted fever 11.2
30 lymphangiosarcoma 11.2
31 hemangioma 11.1
32 bullous keratopathy 11.1
33 pulmonary hypertension, primary, 1 11.1
34 cerebral cavernous malformations 11.1
35 hemolytic-uremic syndrome 11.1
36 hepatic veno-occlusive disease 11.0
37 macular dystrophy, corneal 11.0
38 heme oxygenase 1 deficiency 11.0
39 aneurysmal bone cysts 11.0
40 capillary malformations, congenital 11.0
41 hemangioma, capillary infantile 11.0
42 kanzaki disease 10.9
43 corneal dystrophy, congenital stromal 10.9
44 lung cancer 10.8
45 vitreoretinochoroidopathy dominant 10.7
46 pulmonary hypertension, primary, 2 10.7
47 epidemic typhus 10.7
48 high molecular weight kininogen deficiency 10.7
49 pulmonary hypertension, primary, 3 10.7
50 malignant hemangioma 10.7

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis

Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.32 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 CXCL10 CXCL11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.32 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 CXCL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.32 CXCL11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CXCL11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.32 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 CXCL10

Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
2 Ganciclovir triphosphate Phase 4
3 Nucleic Acid Synthesis Inhibitors Phase 4
4 Anti-Infective Agents Phase 4
5 Antiviral Agents Phase 4
6 Tetrahydrozoline Phase 4
7 Ophthalmic Solutions Phase 4
8 Pharmaceutical Solutions Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
2 Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis Unknown status NCT01359995
3 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Ganciclovir

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

38
Endothelial, Monocytes, Brain, Lung, Neutrophil, Smooth Muscle, Heart

Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 26373)
# Title Authors Year
1
Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. ( 29338061 )
2018
2
Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors. ( 29316425 )
2018
3
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
4
Adipokine expression and endothelial function in subclinical hypothyroidism rats. ( 29440225 )
2018
5
Arterial stenosis in antiphospholipid syndrome: Update on the unrevealed mechanisms of an endothelial disease. ( 29339317 )
2018
6
An intravascular papillary endothelial hyperplasia of the hand radiologically mimicking a hemangiopericytoma: A case report and literature review. ( 29348916 )
2018
7
Use of Defibrotide to help prevent post-transplant endothelial injury in a genetically predisposed infant with metachromatic leukodystrophy undergoing hematopoietic stem cell gene therapy. ( 29379168 )
2018
8
Visual Outcomes Based on Early Response to Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema. ( 29316563 )
2018
9
Phosphatidylserine-exposing blood and endothelial cells contribute to the hypercoagulable state in essential thrombocythemia patients. ( 29332224 )
2018
10
Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan: Role of Angiotensin II Receptor Type 1-Independent Activation of Endothelial Function. ( 29433732 )
2018
11
Corrigendum to "Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery" [Med. Hypotheses 104 (2017) 20-24]. ( 29406994 )
2018
12
MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway. ( 29203244 )
2018
13
Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. ( 29449333 )
2018
14
Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. ( 29252902 )
2018
15
Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy. ( 29408827 )
2018
16
Intravascular Papillary Endothelial Hyperplasia as an unusual diagnosis for peri-orbital tumour - A case report. ( 29283152 )
2018
17
Multiple target autoantigens on endothelial cells identified in juvenile dermatomyositis using proteomics. ( 29361142 )
2018
18
The association between oxidative stress and endothelial dysfunction in early childhood patients with Kawasaki disease. ( 29426283 )
2018
19
Corneal endothelial alterations in alcohol dependence syndrome. ( 29305345 )
2018
20
miRa89186, a serum microRNA, induces endothelial cell apoptosis by targeting SMAD6 in Kawasaki disease. ( 29344637 )
2018
21
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. ( 29294389 )
2018
22
Endothelial JAK2<sup>V617F</sup>does not enhance liver lesions in mice with Budd-Chiari syndrome. ( 29360553 )
2018
23
Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo hemorrhagic fever patients. ( 29159591 )
2018
24
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility. ( 29017932 )
2018
25
CD40L and TNF both activate the classical NF-I_B pathway, which is not required for the CD40L induced alternative pathway in endothelial cells. ( 29183724 )
2018
26
Vascular Endothelial Growth Factor-A165b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury. ( 29393270 )
2018
27
Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia. ( 29438260 )
2018
28
Placental Growth Factor in Bladder Cancer Compared to the Diagnostic Accuracy and Prognostic Performance of Vascular Endothelial Growth Factor A. ( 29277778 )
2018
29
Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence? ( 29350686 )
2018
30
Upregulation of Vascular Endothelial Growth Factor in Amniotic Fluid Stem Cells Enhances Their Potential to Attenuate Lung Injury in a Preterm Rabbit Model of Bronchopulmonary Dysplasia. ( 29393249 )
2018
31
Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells. ( 29317200 )
2018
32
Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. ( 28639275 )
2018
33
High speed flow cytometry allows the detection of circulating endothelial cells in hemangioblastoma patients. ( 29133210 )
2018
34
Evolving therapies for Fuchs' endothelial dystrophy. ( 29360003 )
2018
35
The Iridocorneal Endothelial Syndrome. ( 29331589 )
2018
36
Phenotypic Characterization of Corneal Endothelial Dystrophy in German Shorthaired and Wirehaired Pointers Using In Vivo Advanced Corneal Imaging and Histopathology. ( 29077583 )
2018
37
Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Does Flavor Matter? ( 29392302 )
2018
38
Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )
2018
39
Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. ( 29384808 )
2018
40
Effect of psychostimulants on blood pressure profile and endothelial function in narcolepsy. ( 29321233 )
2018
41
Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation. ( 29137978 )
2018
42
Somatic second hit mutation of RASA1 in vascular endothelial cells in capillary malformation-arteriovenous malformation. ( 29024832 )
2018
43
Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1I+. ( 29443732 )
2018
44
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. ( 29393109 )
2018
45
Hyperglycemia induced testicular damage in type 2 diabetes mellitus rats exhibiting microcirculation impairments associated with vascular endothelial growth factor decreased via PI3K/Akt pathway. ( 29435181 )
2018
46
Survivin regulated by autophagy mediates hyperglycemia-induced vascular endothelial cell dysfunction. ( 29391151 )
2018
47
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma. ( 29416107 )
2018
48
Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan. ( 29102546 )
2018
49
MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease. ( 29343815 )
2018
50
Occludin as a functional marker of vascular endothelial cells on tube-forming activity. ( 28681912 )
2018

Variations for Endotheliitis

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CXCL10 CXCL11 CXCL9
2
Show member pathways
12.95 CXCL10 CXCL11 CXCL9
3
Show member pathways
12.82 CXCL10 CXCL11 CXCL9
4
Show member pathways
12.7 CXCL10 CXCL11 CXCL9
5
Show member pathways
12.36 CXCL10 CXCL11 CXCL9
6
Show member pathways
11.92 CXCL10 CXCL11 CXCL9
7
Show member pathways
11.69 CXCL10 CXCL11
8
Show member pathways
11.65 CXCL10 CXCL11 CXCL9
9
Show member pathways
11.2 CXCL10 CXCL11 CXCL9
10 10.89 CXCL10 CXCL9
11 10.56 CXCL10 CXCL11 CXCL9
12 10.48 CXCL10 CXCL11 CXCL9
13 10.33 CXCL10 CXCL11 CXCL9

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.13 CXCL10 CXCL11 CXCL9
2 external side of plasma membrane GO:0009897 8.62 CXCL10 CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.74 CXCL10 CXCL11 CXCL9
2 G-protein coupled receptor signaling pathway GO:0007186 9.72 CXCL10 CXCL11 CXCL9
3 immune response GO:0006955 9.71 CXCL10 CXCL11 CXCL9
4 regulation of receptor activity GO:0010469 9.7 CXCL10 CXCL11 CXCL9
5 inflammatory response GO:0006954 9.69 CXCL10 CXCL11 CXCL9
6 cell-cell signaling GO:0007267 9.67 CXCL10 CXCL11 CXCL9
7 regulation of cell proliferation GO:0042127 9.65 CXCL10 CXCL11 CXCL9
8 response to lipopolysaccharide GO:0032496 9.61 CXCL10 CXCL11 CXCL9
9 chemotaxis GO:0006935 9.58 CXCL10 CXCL11 CXCL9
10 defense response to virus GO:0051607 9.56 CXCL10 CXCL9
11 defense response GO:0006952 9.54 CXCL10 CXCL11 CXCL9
12 chemokine-mediated signaling pathway GO:0070098 9.5 CXCL10 CXCL11 CXCL9
13 positive regulation of leukocyte chemotaxis GO:0002690 9.46 CXCL11 CXCL9
14 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.43 CXCL10 CXCL11 CXCL9
15 positive regulation of cAMP-mediated signaling GO:0043950 9.33 CXCL10 CXCL11 CXCL9
16 positive regulation of cAMP metabolic process GO:0030816 9.13 CXCL10 CXCL11 CXCL9
17 T cell chemotaxis GO:0010818 8.8 CXCL10 CXCL11 CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CXCL10 CXCL11 CXCL9
2 heparin binding GO:0008201 9.26 CXCL10 CXCL11
3 chemokine activity GO:0008009 9.13 CXCL10 CXCL11 CXCL9
4 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL10 CXCL11 CXCL9

Sources for Endotheliitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....