MCID: END072
MIFTS: 42

Endotheliitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

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Aliases & Descriptions for Endotheliitis:

Name: Endotheliitis 53

Classifications:

Orphanet: 53 
Rare eye diseases


External Ids:

Orphanet53 ORPHA137602

Summaries for Endotheliitis

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Wikipedia:70 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards based summary: Endotheliitis is related to erythema multiforme and membranoproliferative glomerulonephritis. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways are Type II interferon signaling (IFNG) and Bacterial infections in CF airways. Affiliated tissues include endothelial, monocytes and brain.

Related Diseases for Endotheliitis

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Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 935)
idRelated DiseaseScoreTop Affiliating Genes
1erythema multiforme28.0CXCL10, CXCL11
2membranoproliferative glomerulonephritis27.5CXCL10, CXCL11
3fuchs' endothelial dystrophy12.3
4corneal endothelial dystrophy 2, autosomal recessive12.2
5corneal dystrophy, fuchs endothelial, 112.1
6corneal dystrophy, fuchs endothelial, 312.1
7intravascular papillary endothelial hyperplasia12.1
8corneal dystrophy, fuchs endothelial, 612.1
9corneal dystrophy, fuchs endothelial, 412.1
10corneal endothelial dystrophy 1, autosomal dominant12.1
11corneal dystrophy, endothelial, x-linked12.1
12iridocorneal endothelial syndrome12.1
13corneal dystrophy, fuchs endothelial, 812.0
14corneal endothelial dystrophy12.0
15corneal dystrophy, fuchs endothelial, 212.0
16corneal dystrophy, fuchs endothelial, 511.9
17corneal endothelial dystrophy type 211.8
18corneal endothelial dystrophy and perceptive deafness11.8
19corneal dystrophy, fuchs endothelial, 711.7
20corneal dystrophy, posterior polymorphous, 111.6
21edict syndrome11.5
22hemangioma11.2
23spotted fever11.1
24lymphangiosarcoma11.1
25bullous keratopathy11.0
26hemolytic-uremic syndrome11.0
27capillary leak syndrome11.0
28alzheimer disease10.9
29aneurysmal bone cysts10.9
30macular corneal dystrophy10.9
31heme oxygenase-1 deficiency10.9
32essential iris atrophy10.9
33capillary malformations, congenital, 1, somatic, mosaic10.9
34hemangioma, capillary infantile10.8
35corneal dystrophy, congenital stromal10.8
36lung cancer10.8
37gaucher disease, type i10.6
38pulmonary hypertension, primary, 410.6
39pulmonary hypertension, familial primary, 1, with or without hht10.6
40cerebral cavernous malformations-110.6
41plasminogen activator inhibitor-1 deficiency10.6
42pulmonary hypertension, primary, 310.6
43venous malformations, multiple cutaneous and mucosal10.6
44pulmonary hypertension, primary, 210.6
45high molecular weight kininogen deficiency10.6
46carrion's disease10.6
47capillary disease10.6
48hypoxia10.5
49neuroblastoma10.4
50breast cancer10.4

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Symptoms for Endotheliitis

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Drugs & Therapeutics for Endotheliitis

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Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ganciclovirapproved, investigationalPhase 415182410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3
2Nucleic Acid Synthesis InhibitorsPhase 44855
3Anti-Infective AgentsPhase 421402
4Ganciclovir triphosphatePhase 4151
5Antiviral AgentsPhase 49732
6TetrahydrozolinePhase 4593
7Ophthalmic SolutionsPhase 41092
8Pharmaceutical SolutionsPhase 47793

Interventional clinical trials:

idNameStatusNCT IDPhase
1Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / EndotheliitisRecruitingNCT02943057Phase 4
2Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus EndotheliitisUnknown statusNCT01359995
3Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / EndotheliitisCompletedNCT01647529

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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MalaCards organs/tissues related to Endotheliitis:

35
Endothelial, Monocytes, Brain, Lung, Neutrophil, Smooth muscle, Heart

Animal Models for Endotheliitis or affiliated genes

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Publications for Endotheliitis

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Articles related to Endotheliitis:

(show top 50)    (show all 25444)
idTitleAuthorsYear
1
Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells. (27036881)
2016
2
Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein. (26707483)
2016
3
Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR. (26631725)
2016
4
Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. (26002762)
2015
5
Analysis of relative expression level of VEGF ( vascular endothelial growth factor ), HIF-1I+ ( hypoxia inducible factor 1I+ ) and CTGF ( connective tissue growth factor ) genes in chronic glomerulonephritis (CGN) patients. (24577260)
2013
6
Initial contact of glioblastoma cells with existing normal brain endothelial cells strengthen the barrier function via fibroblast growth factor 2 secretion: a new in vitro blood-brain barrier model. (23385422)
2013
7
Culture of human corneal endothelial cells isolated from corneas with Fuchs endothelial corneal dystrophy. (22134119)
2012
8
Expression of vascular endothelial growth factor can predict distant metastasis and disease-free survival for clinical stage III rectal cancer following 30-Gy/10-f preoperative radiotherapy. (22645074)
2012
9
MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis. (22917031)
2012
10
Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. (21896863)
2011
11
RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration. (22001926)
2011
12
Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT). (21906391)
2011
13
Functional polymorphisms in transforming growth factor-beta-1 (TGFbeta-1) and vascular endothelial growth factor (VEGF) genes modify risk of renal parenchymal scarring following childhood urinary tract infection. (19861314)
2010
14
A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells. (20529672)
2010
15
Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells. (20701913)
2010
16
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. (19546852)
2009
17
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
18
Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. (18172091)
2008
19
Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients. (17983459)
2008
20
Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. (18397880)
2008
21
Extracellular HSP70 blocks CD40L-induced apoptosis and tubular formation in endothelial cells. (19120902)
2008
22
Serum level changes of matrix metalloproteinases 2 and 9, vascular endothelial growth factor and epidermal growth factor receptor during platinum-based chemotherapy in advanced non-small cell lung cancer patients. (17436410)
2007
23
DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer. (17230534)
2007
24
Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes. (18173920)
2007
25
Expression of vascular endothelial growth factor in tumors and plasma from dogs with primary intracranial neoplasms. (17975980)
2007
26
Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. (17353160)
2006
27
Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. (16682802)
2006
28
Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function. (16959372)
2006
29
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
30
LPS inhibits endothelin-1-induced endothelial NOS activation in hepatic sinusoidal cells through a negative feedback involving caveolin-1. (16374854)
2006
31
High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells. (12637339)
2003
32
Vascular endothelial growth factor is associated with the efficacy of endocrine therapy in patients with advanced breast carcinoma. (14601081)
2003
33
A protective role for endothelial nitric oxide synthase in glomerulonephritis. (11849432)
2002
34
Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells. (12407018)
2002
35
Elevated plasma levels of vascular endothelial growth factor and plasminogen activator inhibitor-1 decrease during improvement of psoriasis. (12540021)
2002
36
The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. (12239635)
2002
37
Glycated high-density lipoprotein induces apoptosis of endothelial cells via a mitochondrial dysfunction. (11563854)
2001
38
HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis. (11479208)
2001
39
A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: receptor complex. (11325835)
2001
40
Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. (10671553)
2000
41
Adhesion of human umbilical vein endothelial cells to the immediate- early gene product Cyr61 is mediated through integrin alphavbeta3. (9446626)
1998
42
Collagenase-1, stromelysin-1 and 92 kDa gelatinase are associated with tumor necrosis factor-alpha induced morphological change of human endothelial cells in vitro. (9749945)
1998
43
Prolonged E-selectin induction by monocytes potentiates the adhesion of flowing neutrophils to cultured endothelial cells. (8562395)
1996
44
Endothelin 1 and thrombin synergistically stimulate IL-6 mRNA expression and protein production in human umbilical vein endothelial cells. (8587460)
1995
45
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers. (7528721)
1994
46
Growth-promoting effects of substance P on endothelial cells in vitro. Synergism with calcitonin gene-related peptide, insulin, and plasma factors. (7525104)
1994
47
Immunohistochemical properties of the endothelial cells in the human uterus during the menstrual cycle. (7691867)
1993
48
Circulating thrombomodulin as a novel endothelial cell marker: comparison of its behavior with von Willebrand factor and tissue-type plasminogen activator. (1323930)
1992
49
Endothelial modulation of myocardial contraction: mechanisms and potential relevance in cardiac disease. (1299211)
1992
50
Chloroquine's modulation of endothelial cell activity induced with basic fibroblast growth factor and human serum: effect on mitogenesis, protease production and cell migration. (2110509)
1990

Variations for Endotheliitis

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Expression for genes affiliated with Endotheliitis

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Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

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Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.3CXCL10, CXCL9
2
Show member pathways
9.0CXCL10, CXCL11
3
Show member pathways
8.5CXCL10, CXCL11, CXCL9
4
Show member pathways
8.5CXCL10, CXCL11, CXCL9
5
Show member pathways
8.5CXCL10, CXCL11, CXCL9
6
Show member pathways
8.5CXCL10, CXCL11, CXCL9
7
Show member pathways
8.5CXCL10, CXCL11, CXCL9
8
Show member pathways
8.5CXCL10, CXCL11, CXCL9
98.5CXCL10, CXCL11, CXCL9
10
Show member pathways
8.5CXCL10, CXCL11, CXCL9
118.5CXCL10, CXCL11, CXCL9

GO Terms for genes affiliated with Endotheliitis

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Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.4CXCL10, CXCL9
2extracellular spaceGO:00056158.5CXCL10, CXCL11, CXCL9
3extracellular regionGO:00055768.2CXCL10, CXCL11, CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:00516079.7CXCL10, CXCL9
2positive regulation of leukocyte chemotaxisGO:00026909.6CXCL11, CXCL9
3T cell chemotaxisGO:00108189.5CXCL10, CXCL11
4positive regulation of cAMP-mediated signalingGO:00439509.0CXCL10, CXCL11, CXCL9
5positive regulation of cAMP metabolic processGO:00308169.0CXCL10, CXCL11, CXCL9
6response to lipopolysaccharideGO:00324969.0CXCL10, CXCL11, CXCL9
7chemokine-mediated signaling pathwayGO:00700988.9CXCL10, CXCL11, CXCL9
8inflammatory responseGO:00069548.9CXCL10, CXCL11, CXCL9
9cell-cell signalingGO:00072678.9CXCL10, CXCL11, CXCL9
10chemotaxisGO:00069358.8CXCL10, CXCL11, CXCL9
11immune responseGO:00069558.8CXCL10, CXCL11, CXCL9
12regulation of cell proliferationGO:00421278.8CXCL10, CXCL11, CXCL9
13positive regulation of release of sequestered calcium ion into cytosolGO:00512818.6CXCL10, CXCL11, CXCL9
14signal transductionGO:00071658.5CXCL10, CXCL11, CXCL9
15G-protein coupled receptor signaling pathwayGO:00071868.2CXCL10, CXCL11, CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082018.9CXCL10, CXCL11
2CXCR3 chemokine receptor bindingGO:00482488.5CXCL10, CXCL11, CXCL9
3chemokine activityGO:00080098.2CXCL10, CXCL11, CXCL9

Sources for Endotheliitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet