MCID: END072
MIFTS: 50

Endotheliitis malady

Eye diseases, Rare diseases categories
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Summaries for Endotheliitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards: Endotheliitis is related to breast cancer and atherosclerosis. An important gene associated with Endotheliitis is CXCL11 (chemokine (C-X-C motif) ligand 11), and among its related pathways are Type II interferon signaling (IFNG) and Immune response Bacterial infections in normal airways. The compounds lysophosphatidylcholine and groalpha have been mentioned in the context of this disorder. Affiliated tissues include endothelial, monocytes and brain.

Aliases & Classifications for Endotheliitis

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49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 49 
Rare eye diseases


Aliases & Descriptions:

endotheliitis 49


Related Diseases for Endotheliitis

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17GeneCards, 18GeneDecks
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Diseases related to Endotheliitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 973)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.3CXCL9, CXCL10
2atherosclerosis31.1CXCL10, CXCL9, CXCL11
3arthritis31.0CXCL10, CXCL9
4rheumatoid arthritis30.9CXCL11, CXCL9, CXCL10
5malaria30.7CXCL9
6asthma30.6CXCL9, CXCL10
7psoriasis30.6CXCL9, CXCL10
8astrocytoma30.6CXCL10, CXCL11
9multiple sclerosis30.5CXCL10, CXCL9, CXCL11
10hepatitis c30.4CXCL11, CXCL10
11sarcoidosis30.2CXCL10, CXCL9
12dermatitis30.2CXCL11, CXCL9, CXCL10
13uveitis30.1CXCL10, CXCL11, CXCL9
14idiopathic pulmonary fibrosis30.0CXCL10, CXCL9
15atopic dermatitis30.0CXCL9, CXCL10
16lichen planus30.0CXCL11, CXCL9
17encephalitis29.9CXCL9, CXCL10
18influenza29.9CXCL10, CXCL9
19galactosemia29.8CXCL10, CXCL11
20skin disease29.7CXCL9, CXCL11, CXCL10
21allergic contact dermatitis29.4CXCL11, CXCL9, CXCL10
22mycosis fungoides29.4CXCL11, CXCL9, CXCL10
23hypoxia11.0
24hypertension11.0
25retinitis10.9
26artery disease10.8
27prostatitis10.8
28lung cancer10.8
29cerebritis10.8
30coronary artery disease10.8
31ischemia10.8
32diabetes mellitus10.8
33diabetic retinopathy10.8
34colorectal cancer10.7
35hepatocellular carcinoma10.7
36melanoma10.7
37intravascular papillary endothelial hyperplasia10.7
38pancreatitis10.7
39prostate cancer10.7
40sarcoma10.7
41leukemia10.7
42renal cell carcinoma10.7
43myocardial infarction10.7
44adenocarcinoma10.7
45insulin resistance10.7
46iridocorneal endothelial syndrome10.7
47kaposi's sarcoma10.6
48fuchs' endothelial dystrophy10.6
49hepatitis10.6
50essential hypertension10.6

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Symptoms for Endotheliitis

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Drugs & Therapeutics for Endotheliitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Endotheliitis

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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33MalaCards
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MalaCards organs/tissues related to Endotheliitis:

33
Endothelial, Monocytes, Brain, Lung, Breast, Smooth muscle, Heart, Bone, Prostate, Liver, T cells, Colon, Lymph node, Kidney, Bone marrow, Placenta, Eye, Thyroid, Skin, Myeloid, Ovary, B cells, Pituitary, Skeletal muscle, Retina, Testes, Nk cells, Pancreas, Adipocyte, Tongue, Cervix, Salivary gland, Pancreatic islet, Spleen, Spinal cord, Tonsil, Testis, Whole blood, Fetal liver, Cardiac myocytes, Cortex, Uterus, Fetal brain, Adrenal gland, Cerebellum, Adrenal cortex, Hypothalamus, Fetal lung, Thymus, Small intestine, Dorsal root ganglion

Animal Models for Endotheliitis or affiliated genes

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Publications for Endotheliitis

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52PubMed
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Articles related to Endotheliitis:

(show top 50)    (show all 22611)
idTitleAuthorsYear
1
Culture of human corneal endothelial cells isolated from corneas with Fuchs endothelial corneal dystrophy. (22134119)
2012
2
Expression of vascular endothelial growth factor can predict distant metastasis and disease-free survival for clinical stage III rectal cancer following 30-Gy/10-f preoperative radiotherapy. (22645074)
2012
3
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
4
Recruitment of I+7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. (21861625)
2011
5
Vascular-endothelial growth factor and its high affinity receptor VEGFR-2 in the normal versus destructive lesions human forebrain during development: an immuno-histochemical comparative study. (21303671)
2011
6
Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. (21896863)
2011
7
Association between homocysteine and endothelial dysfunction markers in stroke disease. (20132648)
2010
8
Functional polymorphisms in transforming growth factor-beta-1 (TGFbeta-1) and vascular endothelial growth factor (VEGF) genes modify risk of renal parenchymal scarring following childhood urinary tract infection. (19861314)
2010
9
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. (19546852)
2009
10
Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. (19608750)
2009
11
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
12
Effect of alpha-zearalanol upon the expression of HO-1 gene and the cytosolic free calcium level in tumor necrosis factor alpha-stimulated human endothelial cell]. (20193368)
2009
13
Endothelial cell loss during pterygium surgery: importance of timing of mitomycin C application. (19654528)
2009
14
Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. (18172091)
2008
15
Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease. (18612318)
2008
16
Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients. (17983459)
2008
17
R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. (17566113)
2007
18
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. (17478731)
2007
19
Serum level changes of matrix metalloproteinases 2 and 9, vascular endothelial growth factor and epidermal growth factor receptor during platinum-based chemotherapy in advanced non-small cell lung cancer patients. (17436410)
2007
20
DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer. (17230534)
2007
21
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. (17155946)
2007
22
Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes. (18173920)
2007
23
Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. (17353160)
2006
24
ERK is an anti-inflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells. (16242916)
2006
25
Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. (16682802)
2006
26
Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function. (16959372)
2006
27
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
28
Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. (15983116)
2005
29
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. (14965340)
2004
30
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. (15117840)
2004
31
Molecular mechanisms of impaired endothelial function associated with insulin resistance. (15032648)
2004
32
Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. (15051034)
2004
33
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
34
Intravascular papillary endothelial hyperplasia arising from the upper lip. (12956089)
2003
35
11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. (12773534)
2003
36
A protective role for endothelial nitric oxide synthase in glomerulonephritis. (11849432)
2002
37
Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors. (11934836)
2002
38
Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells. (12407018)
2002
39
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. (11489932)
2001
40
Schistosoma hematobium soluble egg antigens induce proliferation of urothelial and endothelial cells. (11550787)
2001
41
Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes. (11005205)
2000
42
Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells. (10628338)
1999
43
GAS6 inhibits granulocyte adhesion to endothelial cells. (9516131)
1998
44
Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. (9615749)
1998
45
Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies. (9043923)
1997
46
Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. (9036871)
1997
47
Endothelial cell proliferation regulated by cytokines modulates thrombospondin-1 secretion into the subendothelium. (9344505)
1997
48
Prolonged E-selectin induction by monocytes potentiates the adhesion of flowing neutrophils to cultured endothelial cells. (8562395)
1996
49
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers. (7528721)
1994
50
Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa. (8063724)
1994

Variations for Endotheliitis

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Expression for genes affiliated with Endotheliitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 30KEGG, 55Reactome, 54R&D Systems
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Pathways related to Endotheliitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CXCL9, CXCL10
2
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0CXCL10, CXCL11
3
Show member pathways
8.5CXCL9, CXCL11, CXCL10
4
Show member pathways
8.5CXCL10, CXCL9, CXCL11
5
Show member pathways
8.5CXCL10, CXCL9, CXCL11
6
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5CXCL11, CXCL10, CXCL9
7
Show member pathways
8.5CXCL11, CXCL9, CXCL10
8
Show member pathways
8.5CXCL11, CXCL9, CXCL10
9
Show member pathways
8.5CXCL11, CXCL9, CXCL10
10
Show member pathways
8.5CXCL11, CXCL9, CXCL10
11
Show member pathways
8.5CXCL11, CXCL9, CXCL10
128.5CXCL11, CXCL9, CXCL10
13
Show member pathways
8.5CXCL11, CXCL9, CXCL10

Compounds for genes affiliated with Endotheliitis

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29IUPHAR, 45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank
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Compounds related to Endotheliitis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1lysophosphatidylcholine29 4510.5CXCL11, CXCL9
2groalpha459.3CXCL9, CXCL10
3il 10459.2CXCL9, CXCL10
4ifn-alpha459.2CXCL9, CXCL10
5endotoxin459.1CXCL9, CXCL10
6creatinine459.1CXCL9, CXCL10
7histamine45 29 2411.0CXCL10, CXCL9
8tarc458.8CXCL11, CXCL9, CXCL10
9ccl345 299.8CXCL11, CXCL9, CXCL10
10ccl445 299.7CXCL10, CXCL9, CXCL11
11rantes458.7CXCL11, CXCL9, CXCL10
12dexamethasone45 51 29 1111.7CXCL10, CXCL9, CXCL11
13calcium45 51 24 1111.2CXCL11, CXCL9, CXCL10

GO Terms for genes affiliated with Endotheliitis

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16Gene Ontology
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Cellular components related to Endotheliitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1CXCL9, CXCL10
2extracellular spaceGO:0056158.4CXCL11, CXCL9, CXCL10
3extracellular regionGO:0055768.2CXCL11, CXCL9, CXCL10

Biological processes related to Endotheliitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1T cell chemotaxisGO:0108189.2CXCL11, CXCL10
2G-protein coupled receptor signaling pathwayGO:0071869.1CXCL9, CXCL10
3chemokine-mediated signaling pathwayGO:0700989.0CXCL10, CXCL11
4defense response to virusGO:0516078.8CXCL9, CXCL10
5positive regulation of cAMP metabolic processGO:0308168.8CXCL11, CXCL9, CXCL10
6positive regulation of cAMP-mediated signalingGO:0439508.8CXCL10, CXCL9, CXCL11
7positive regulation of release of sequestered calcium ion into cytosolGO:0512818.7CXCL11, CXCL9, CXCL10
8regulation of cell proliferationGO:0421278.7CXCL10, CXCL9, CXCL11
9chemotaxisGO:0069358.7CXCL11, CXCL9, CXCL10
10cell-cell signalingGO:0072678.7CXCL10, CXCL9, CXCL11
11inflammatory responseGO:0069548.6CXCL11, CXCL9, CXCL10
12immune responseGO:0069558.6CXCL11, CXCL9, CXCL10
13signal transductionGO:0071658.4CXCL11, CXCL9, CXCL10

Molecular functions related to Endotheliitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.0CXCL11, CXCL10
2CXCR3 chemokine receptor bindingGO:0482488.4CXCL11, CXCL9, CXCL10
3chemokine activityGO:0080098.2CXCL11, CXCL9, CXCL10

Products for genes affiliated with Endotheliitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endotheliitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet