MCID: END072
MIFTS: 39

Endotheliitis malady

Eye diseases, Rare diseases categories

Aliases & Classifications for Endotheliitis

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Aliases & Descriptions for Endotheliitis:

Name: Endotheliitis 51


Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Orphanet51 137602

Summaries for Endotheliitis

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Wikipedia:68 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards based summary: Endotheliitis is related to acute pancreatitis and erythema multiforme. An important gene associated with Endotheliitis is CXCL10 (Chemokine (C-X-C Motif) Ligand 10), and among its related pathways are Type II interferon signaling (IFNG) and Bacterial infections in CF airways. Affiliated tissues include endothelial, monocytes and brain.

Related Diseases for Endotheliitis

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Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Symptoms for Endotheliitis

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Drugs & Therapeutics for Endotheliitis

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Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ganciclovirapproved, investigational13982410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene IV
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir Sodium
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3

Interventional clinical trials:

idNameStatusNCT IDPhase
1Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / EndotheliitisCompletedNCT01647529
2Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus EndotheliitisRecruitingNCT01359995

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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MalaCards organs/tissues related to Endotheliitis:

33
Endothelial, Monocytes, Brain, Lung, Breast, Neutrophil, Smooth muscle

Animal Models for Endotheliitis or affiliated genes

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Publications for Endotheliitis

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Articles related to Endotheliitis:

(show top 50)    (show all 24264)
idTitleAuthorsYear
1
Analysis of relative expression level of VEGF ( vascular endothelial growth factor ), HIF-1I+ ( hypoxia inducible factor 1I+ ) and CTGF ( connective tissue growth factor ) genes in chronic glomerulonephritis (CGN) patients. (24577260)
2013
2
Culture of human corneal endothelial cells isolated from corneas with Fuchs endothelial corneal dystrophy. (22134119)
2012
3
Expression of vascular endothelial growth factor can predict distant metastasis and disease-free survival for clinical stage III rectal cancer following 30-Gy/10-f preoperative radiotherapy. (22645074)
2012
4
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
5
Recruitment of I+7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. (21861625)
2011
6
Vascular-endothelial growth factor and its high affinity receptor VEGFR-2 in the normal versus destructive lesions human forebrain during development: an immuno-histochemical comparative study. (21303671)
2011
7
Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. (21896863)
2011
8
Association between homocysteine and endothelial dysfunction markers in stroke disease. (20132648)
2010
9
Functional polymorphisms in transforming growth factor-beta-1 (TGFbeta-1) and vascular endothelial growth factor (VEGF) genes modify risk of renal parenchymal scarring following childhood urinary tract infection. (19861314)
2010
10
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. (19546852)
2009
11
Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. (19608750)
2009
12
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
13
Effect of alpha-zearalanol upon the expression of HO-1 gene and the cytosolic free calcium level in tumor necrosis factor alpha-stimulated human endothelial cell]. (20193368)
2009
14
Endothelial cell loss during pterygium surgery: importance of timing of mitomycin C application. (19654528)
2009
15
Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. (18172091)
2008
16
Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease. (18612318)
2008
17
Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients. (17983459)
2008
18
R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. (17566113)
2007
19
RhoA-dependent PAI-1 gene expression induced in endothelial cells by monocyte adhesion mediates geranylgeranyl transferase I and Ca2+ signaling. (16973169)
2007
20
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. (17478731)
2007
21
Serum level changes of matrix metalloproteinases 2 and 9, vascular endothelial growth factor and epidermal growth factor receptor during platinum-based chemotherapy in advanced non-small cell lung cancer patients. (17436410)
2007
22
DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer. (17230534)
2007
23
Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. (17353160)
2006
24
ERK is an anti-inflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells. (16242916)
2006
25
Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. (16682802)
2006
26
Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function. (16959372)
2006
27
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
28
Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. (15983116)
2005
29
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. (14965340)
2004
30
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. (15117840)
2004
31
Molecular mechanisms of impaired endothelial function associated with insulin resistance. (15032648)
2004
32
Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. (15051034)
2004
33
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
34
Intravascular papillary endothelial hyperplasia arising from the upper lip. (12956089)
2003
35
11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. (12773534)
2003
36
A protective role for endothelial nitric oxide synthase in glomerulonephritis. (11849432)
2002
37
Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors. (11934836)
2002
38
Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells. (12407018)
2002
39
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. (11489932)
2001
40
Schistosoma hematobium soluble egg antigens induce proliferation of urothelial and endothelial cells. (11550787)
2001
41
Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes. (11005205)
2000
42
Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells. (10628338)
1999
43
GAS6 inhibits granulocyte adhesion to endothelial cells. (9516131)
1998
44
Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. (9615749)
1998
45
Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies. (9043923)
1997
46
Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. (9036871)
1997
47
Endothelial cell proliferation regulated by cytokines modulates thrombospondin-1 secretion into the subendothelium. (9344505)
1997
48
Endothelial P2-purinoceptors: subtypes and signal transduction. (9131415)
1996
49
Prolonged E-selectin induction by monocytes potentiates the adhesion of flowing neutrophils to cultured endothelial cells. (8562395)
1996
50
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers. (7528721)
1994

Variations for Endotheliitis

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Expression for genes affiliated with Endotheliitis

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Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

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Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCL10, CXCL9
2
Show member pathways
9.0CXCL10, CXCL11
3
Show member pathways
8.5CXCL10, CXCL11, CXCL9
4
Show member pathways
8.5CXCL10, CXCL11, CXCL9
5
Show member pathways
8.5CXCL10, CXCL11, CXCL9
6
Show member pathways
8.5CXCL10, CXCL11, CXCL9
7
Show member pathways
8.5CXCL10, CXCL11, CXCL9
8
Show member pathways
8.5CXCL10, CXCL11, CXCL9
9
Show member pathways
8.5CXCL10, CXCL11, CXCL9
10
Show member pathways
8.5CXCL10, CXCL11, CXCL9
118.5CXCL10, CXCL11, CXCL9

GO Terms for genes affiliated with Endotheliitis

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Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.8CXCL10, CXCL9
2extracellular spaceGO:00056158.5CXCL10, CXCL11, CXCL9
3extracellular regionGO:00055768.2CXCL10, CXCL11, CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:00516079.6CXCL10, CXCL9
2positive regulation of cAMP metabolic processGO:00308169.0CXCL10, CXCL11, CXCL9
3positive regulation of cAMP-mediated signalingGO:00439509.0CXCL10, CXCL11, CXCL9
4positive regulation of release of sequestered calcium ion into cytosolGO:00512819.0CXCL10, CXCL11, CXCL9
5T cell chemotaxisGO:00108189.0CXCL10, CXCL11, CXCL9
6cell-cell signalingGO:00072679.0CXCL10, CXCL11, CXCL9
7positive regulation of leukocyte chemotaxisGO:00026909.0CXCL10, CXCL11, CXCL9
8response to lipopolysaccharideGO:00324968.9CXCL10, CXCL11, CXCL9
9inflammatory responseGO:00069548.9CXCL10, CXCL11, CXCL9
10chemokine-mediated signaling pathwayGO:00700988.9CXCL10, CXCL11, CXCL9
11chemotaxisGO:00069358.8CXCL10, CXCL11, CXCL9
12immune responseGO:00069558.8CXCL10, CXCL11, CXCL9
13regulation of cell proliferationGO:00421278.6CXCL10, CXCL11, CXCL9
14G-protein coupled receptor signaling pathwayGO:00071868.5CXCL10, CXCL11, CXCL9
15signal transductionGO:00071658.2CXCL10, CXCL11, CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.1CXCL10, CXCL11
2CXCR3 chemokine receptor bindingGO:00482488.7CXCL10, CXCL11, CXCL9
3chemokine activityGO:00080098.5CXCL10, CXCL11, CXCL9

Sources for Endotheliitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet