MCID: END072
MIFTS: 51

Endotheliitis malady

Eye category

Summaries for Endotheliitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards: Endotheliitis is related to vascular disease and atherosclerosis. An important gene associated with Endotheliitis is TNFSF15 (tumor necrosis factor (ligand) superfamily, member 15), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Rho Family GTPases. The compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related mouse phenotypes are cardiovascular system and cellular.

Aliases & Classifications for Endotheliitis

Sources:
49Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

endotheliitis 49


Related Diseases for Endotheliitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 900)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.4S1PR1, LIPG, NOS3, TEK, SELE, SELP
2atherosclerosis31.2STAB1, FLT1, LIPG, CDH5, FGF1, NOS3
3coronary artery disease,31.2CDH5, FGF1, NOS3, TEK, SELE, SELP
4colorectal cancer31.1FLT1, VEGFC, TYMP, CDH5, TEK, SELP
5arthritis31.0FLT1, FGF1, TEK, SELE
6adenocarcinoma31.0VEGFC, TYMP, CDH5, FGF1, TEK
7kaposi's sarcoma30.9SELE, TEK, FGF1, VEGFC
8proliferative diabetic retinopathy30.8SELP, FLT1
9acute myocardial infarction30.8CDH5, TEK, SELE, SELP
10sepsis30.8S1PR1, NOS3, TEK, SELE, SELP
11hypercholesterolemia30.7NOS3, SELE, SELP
12coronary heart disease30.7LIPG, NOS3, SELE, SELP
13vasculitis30.7SELP, SELE
14kawasaki disease30.6SELE
15arteriosclerosis30.6FGF1, NOS3
16peripheral vascular disease30.5SELE, SELP
17hyperhomocysteinemia30.5SELP, SELE, NOS3
18antiphospholipid syndrome30.5SELP, SELE
19hepatitis c30.4TYMP
20thyroid cancer30.4VEGFC, TEK
21bladder carcinoma30.4FGF1, TYMP
22angiosarcoma30.4FLT1, VEGFC, CDH5, TEK
23sickle cell disease30.4NOS3, SELE, SELP
24intermittent claudication30.3SELP
25transitional cell carcinoma30.3VEGFC, TYMP, FGF1
26intracranial aneurysm30.2NOS3
27brain cancer30.1TEK, NOS3, FGF1, CDH5
28primary pulmonary hypertension30.1TEK, NOS3, FLT1
29thrombophilia30.0SELP, SELE
30tongue cancer29.9FLT1, VEGFC
31stomach cancer29.7TEK, FGF1, TYMP, VEGFC, FLT1
32type 2 diabetes mellitus29.7SELP, SELE, NOS3, TYMP
33age related macular degeneration29.7FLT1
34vascular cancer11.2
35hypoxia11.0
36squamous cell carcinoma10.8
37fuchs' endothelial dystrophy10.7
38intravascular papillary endothelial hyperplasia10.7
39insulin resistance10.6
40iridocorneal endothelial syndrome10.6
41n syndrome10.6
42eclampsia10.6
43systemic lupus erythematosus10.5
44oral squamous cell carcinoma10.5
45acute leukemia10.5
46ovarian hyperstimulation syndrome10.5
47asthma10.5
48diabetic nephropathy10.5
49small cell carcinoma10.4
50bullous keratopathy10.4

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Clinical Features for Endotheliitis

Drugs & Therapeutics for Endotheliitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Endotheliitis

Drug clinical trials:

Search ClinicalTrials for Endotheliitis

Search NIH Clinical Center for Endotheliitis

Search CenterWatch for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Endotheliitis:

33
Endothelial

Animal Models for Endotheliitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Endotheliitis

Sources:
51PubMed
See all sources

Articles related to Endotheliitis:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Bilateral lineal endotheliitis: case report. (23828474)
2013
2
Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty. (23009154)
2013
3
A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR. (23252654)
2013
4
Mapping owl's eye cells of patients with cytomegalovirus corneal endotheliitis using in vivo laser confocal microscopy. (23124832)
2013
5
Concomitant herpes simplex virus and cytomegalovirus endotheliitis in immunocompetent patient. (23667217)
2013
6
Infectious endotheliitis: a rare case of presumed mycotic origin. (23901253)
2013
7
Identification of cytomegalovirus and human herpesvirus-6 DNA in a patient with corneal endotheliitis. (23247975)
2013
8
Post-phacoemulsification cytomegalovirus corneal endotheliitis diagnosis and management. (22768376)
2012
9
Treatment outcome and risk factors for visual loss in Cytomegalovirus endotheliitis. (21892696)
2012
10
Cytomegalovirus associated corneal endotheliitis after penetrating keratoplasty in a patient with Fuchs corneal endothelial dystrophy. (22049489)
2012
11
Endothelial damage after cardiac arrest--"endotheliitis". (22429972)
2012
12
Multiple parallel-line endotheliitis--a form of herpes simplex keratitis? (22179220)
2012
13
Immune ring formation associated with cytomegalovirus endotheliitis. (21676373)
2011
14
Corneal endotheliitis triggered by cataract surgery in a Chinese patient with cytomegalovirus anterior uveitis. (21631677)
2011
15
Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with BehAset uveitis. (21770807)
2011
16
Atypical presentation of cytomegalovirus endotheliitis: a case report. (21034308)
2011
17
Detection of cytomegalovirus DNA from cytomegalovirus corneal endotheliitis after penetrating keratoplasty. (20458221)
2010
18
Corneal endotheliitis with cytomegalovirus infection of corneal stroma. (19816513)
2010
19
Corneal endotheliitis with quantitative polymerase chain reaction positive for human herpesvirus 7. (20385952)
2010
20
Cytomegalovirus endotheliitis following fluocinolone acetonide (Retisert) implant. (19325574)
2010
21
Varicella endotheliitis: a case report. (19882562)
2009
22
Cytomegalovirus endotheliitis in Descemet's stripping endothelial keratoplasty. (19195708)
2009
23
Corneal endotheliitis. (19118704)
2009
24
Livedo, dementia, thrombocytopenia, and endotheliitis without antiphospholipid antibodies: seronegative antiphospholipid-like syndrome. (19646781)
2009
25
Cytomegalovirus as an etiologic factor in corneal endotheliitis. (17669498)
2008
26
Three cases of idiopathic "multiple-parallel-line" endotheliitis. (18245976)
2008
27
Corneal endotheliitis. (18584561)
2008
28
Demonstration of "owl's eye" morphology by confocal microscopy in a patient with presumed cytomegalovirus corneal endotheliitis. (17386293)
2007
29
Progressive herpetic linear endotheliitis. (17413967)
2007
30
DNA of cytomegalovirus detected by PCR in aqueous of patient with corneal endotheliitis after penetrating keratoplasty. (17413969)
2007
31
A case of hypertensive keratouveitis with endotheliitis associated with cytomegalovirus. (17972225)
2007
32
Corneal endotheliitis associated with evidence of cytomegalovirus infection. (17207531)
2007
33
Presumed herpetic endotheliitis following phacoemulsification surgery. (16925717)
2006
34
Mumps-induced corneal endotheliitis. (15097138)
2004
35
Corneal endotheliitis and idiopathic sudden sensorineural hearing loss. (11992869)
2002
36
Isolation of a vesicular virus belonging to the family rhabdoviridae from the aqueous humor of a patient with bilateral corneal endotheliitis. (11917189)
2002
37
Experimental corneal endotheliitis in rabbit. (10670465)
2000
38
Herpes simplex virus in the trabeculum of an eye with corneal endotheliitis. (10372885)
1999
39
Endotheliitis-like changes in chronic hepatitis C. (9151124)
1997
40
Idiopathic sectoral corneal endotheliitis. (8985548)
1996
41
Acyclovir treatment for linear endotheliitis on grafted corneas. (7600816)
1995
42
Atypical herpetic endotheliitis. (7490417)
1995
43
Neutrophilic endotheliitis in patients with idiopathic pulmonary fibrosis. (7634914)
1995
44
Linear endotheliitis. (8154528)
1994
45
Brown-Mclean syndrome associated with corneal endotheliitis in a pseudophakic eye. (8271178)
1993
46
Endotheliitis in hepatic allografts. (2657236)
1989
47
Sporadic diffuse corneal endotheliitis. (2817049)
1989
48
Idiopathic sectoral corneal endotheliitis. (4014400)
1985
49
Progressive herpetic corneal endotheliitis. (2992281)
1985
50
Acute idiopathic corneal endotheliitis. (6676986)
1983

Genetic Variations for Endotheliitis

Expression for genes affiliated with Endotheliitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

Sources:
52QIAGEN, 4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Endotheliitis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
12.4FLT1, PROK1, VEGFC, CDH5, FGF1, NOS3
2
Hide members
12.4COL8A2, FLT1, PROK1, VEGFC, CDH5, FGF1
312.4TEK, NOS3, FGF1, CDH5, TYMP, VEGFC
4
Hide members
12.1FLT1, PROK1, VEGFC, FGF1, NOS3, TEK
5
Hide members
12.1FLT1, PROK1, VEGFC, FGF1, NOS3, TEK
6
Hide members
12.1FLT1, PROK1, VEGFC, FGF1, NOS3, TEK
7
Hide members
11.8FLT1, VEGFC, NOS3, TEK, TNFSF15
811.8FLT1, VEGFC, FGF1, NOS3, TEK
9
Hide members
11.8FLT1, PROK1, VEGFC, FGF1, TEK
10
Hide members
11.8FLT1, PROK1, VEGFC, FGF1, TEK
11
Hide members
11.8TEK, FGF1, VEGFC, PROK1, FLT1
12
Hide members
11.8COL8A2, FLT1, PROK1, VEGFC, FGF1
13
Hide members
11.8S1PR1, FLT1, VEGFC, CDH5, NOS3
14
Hide members
11.8S1PR1, S1PR3, S1PR4, FLT1, CDH5
15
Hide members
11.6NOS3, TEK, SELE, SELP
16
Hide members
11.3NOS3, VEGFC, FLT1
1711.3TEK, NOS3, FLT1
1811.3FLT1, NOS3, TEK
1911.3SELP, SELE, TEK
2011.3S1PR4, S1PR3, S1PR1
21
Hide members
11.3S1PR4, S1PR3, S1PR1
22
Hide members
11.0FLT1, VEGFC
2310.7FGF1
24
Hide members
10.7PROK1

Compounds for genes affiliated with Endotheliitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Endotheliitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1vegf4513.9SELP, S1PR1, FLT1, PROK1, VEGFC, TYMP
2nitric oxide45 11 2415.9VEGFC, LIPG, FLT1, S1PR1, TYMP, CDH5
3lipid4513.3S1PR1, S1PR3, SCARF1, FLT1, LIPG, VEGFC
4tyrosine4513.3S1PR1, S1PR3, FLT1, VEGFC, TYMP, CDH5
5phosphatidylinositol4513.1S1PR1, S1PR3, FLT1, VEGFC, CDH5, FGF1
6oxygen45 2414.0FLT1, LIPG, VEGFC, TYMP, CDH5, FGF1
7matrigel4512.5FLT1, CDH5, FGF1, NOS3, TEK, SELE
8prostacyclin4512.5FLT1, TYMP, FGF1, NOS3, SELE, SELP
9ly2940024512.5S1PR1, VEGFC, TYMP, NOS3, SELE, SELP
10paraffin4512.5FLT1, VEGFC, TYMP, CDH5, FGF1, TEK
11genistein45 29 60 2 11 2417.5FLT1, CDH5, FGF1, NOS3, SELE, SELP
12thymidine45 2413.5S1PR1, FLT1, VEGFC, TYMP, FGF1, TEK
13ribonucleic acid4512.2FLT1, VEGFC, CDH5, FGF1, TEK
14heparin45 29 11 2415.0FLT1, LIPG, SELE, SELP
15formaldehyde45 2412.9TYMP, FGF1, SELE, SELP
16aspirin45 50 29 2414.9TYMP, NOS3, SELE, SELP
17compound 26 [pmid:16190743]2911.7S1PR1, S1PR3, S1PR4
18afd(r)2911.7S1PR1, S1PR3, S1PR4
19cholesterol45 29 11 2414.7FLT1, LIPG, FGF1, SELE, SELP
20w14660 2912.7S1PR1, S1PR3, S1PR4
21sphingosine-1-phosphate6011.7S1PR1, S1PR3, S1PR4
22cym 5442 hydrochloride6011.7S1PR1, S1PR4, S1PR3
23vpc 230196011.7S1PR4, S1PR3, S1PR1
24polysaccharide4511.7CDH5, FGF1, SELE, SELP
25fucoidan4511.7SELP, SELE, SCARF1
26sphingosine 1-phosphate29 2412.6S1PR4, S1PR3, S1PR1
27fenofibrate45 50 1113.6NOS3, SELE, SELP
28dextran sulfate4511.6SELP, SELE, FGF1
29fluvastatin45 50 29 1114.6NOS3, SELE, SELP
30pravastatin45 50 29 11 2415.5NOS3, SELE, SELP
31fc 774511.4SELE, SELP
32bx4714511.4SELP, SELE
33vpc441162911.4S1PR3, S1PR1
34jte 0136011.4S1PR1, S1PR3
354-f-glcnac4511.4SELE, SELP
36O-Sialic Acid1111.3SELE, SELP
37thiolutin6011.3SELE, SELP
38heparin sodium salt6011.3SELE, SELP
39echistatin, alpha1 isoform6011.3SELE, SELP
40rgds peptide6011.3SELE, SELP
41ac2-266011.3SELE, SELP
42slea4511.3SELP, SELE
43tyrosine sulfate4511.3SELP, SELE
44sodium chlorate4511.2SELP, FGF1
45tamoxifen45 50 29 1114.2FGF1, TYMP
46hydroxyethyl starch4511.1SELP, SELE
47quinapril45 1112.1SELP, SELE
48sele4511.0SELE, SELP
49lysophospholipid4511.0S1PR3, S1PR1
50adma4510.7SELE, NOS3

GO Terms for genes affiliated with Endotheliitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Endotheliitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588614.0SELP, S1PR1, S1PR3, S1PR4, TNFSF15, SCARF1
2extracellular spaceGO:00561512.3TNFSF15, FLT1, LIPG, VEGFC, FGF1, SELE
3integral to plasma membraneGO:00588712.1S1PR3, S1PR4, TNFSF15, STAB1, FLT1, TEK
4endocytic vesicle membraneGO:03066611.3NOS3, STAB1, SCARF1

Biological processes related to Endotheliitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:00152513.1TEK, COL8A2, S1PR1, PROK1, VEGFC, ECSCR
2positive regulation of cell proliferationGO:00828412.0S1PR3, FLT1, PROK1, VEGFC, FGF1
3blood coagulationGO:00759611.9VEGFC, NOS3, TEK, SELE, SELP
4positive regulation of angiogenesisGO:04576611.8FLT1, FGF1, NOS3, TEK
5positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.5SELP, TEK, FLT1
6positive regulation of cell divisionGO:05178111.5PROK1, VEGFC, FGF1
7inflammatory responseGO:00695411.5SELP, SELE, STAB1, S1PR3
8positive regulation of cell migrationGO:03033511.3FGF1, FLT1, S1PR1
9positive regulation of intracellular protein kinase cascadeGO:01074011.2TEK, FGF1
10positive regulation of leukocyte migrationGO:00268711.1SELP, SELE
11leukocyte tethering or rollingGO:05090111.0SELE, SELP
12leukocyte migrationGO:05090011.0TEK, SELE, SELP

Molecular functions related to Endotheliitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808311.6PROK1, VEGFC, TYMP, FGF1
2sphingosine-1-phosphate receptor activityGO:03803611.4S1PR4, S1PR3, S1PR1
3transmembrane signaling receptor activityGO:00488811.3SELE, ANTXR1, SCARF1
4oligosaccharide bindingGO:07049211.1SELP, SELE
5sialic acid bindingGO:03369110.9SELP, SELE
6low-density lipoprotein particle bindingGO:03016910.7STAB1, SCARF1

Products for genes affiliated with Endotheliitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endotheliitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet