MCID: END072
MIFTS: 42

Endotheliitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

About this section

Aliases & Descriptions for Endotheliitis:

Name: Endotheliitis 54

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Orphanet54 ORPHA137602

Summaries for Endotheliitis

About this section
Wikipedia:71 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards based summary: Endotheliitis is related to erythema multiforme and membranoproliferative glomerulonephritis. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways are Type II interferon signaling (IFNG) and Bacterial infections in CF airways. Affiliated tissues include endothelial, monocytes and brain, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Endotheliitis

About this section

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 935)
idRelated DiseaseScoreTop Affiliating Genes
1erythema multiforme28.0CXCL10, CXCL11
2membranoproliferative glomerulonephritis27.5CXCL10, CXCL11
3fuchs' endothelial dystrophy12.3
4corneal endothelial dystrophy 2, autosomal recessive12.2
5corneal dystrophy, fuchs endothelial, 112.1
6corneal dystrophy, fuchs endothelial, 312.1
7intravascular papillary endothelial hyperplasia12.1
8corneal dystrophy, fuchs endothelial, 612.1
9corneal dystrophy, fuchs endothelial, 412.1
10corneal endothelial dystrophy 1, autosomal dominant12.1
11corneal dystrophy, endothelial, x-linked12.1
12iridocorneal endothelial syndrome12.1
13corneal dystrophy, fuchs endothelial, 812.0
14corneal endothelial dystrophy12.0
15corneal dystrophy, fuchs endothelial, 212.0
16corneal dystrophy, fuchs endothelial, 511.9
17corneal endothelial dystrophy type 211.8
18corneal endothelial dystrophy and perceptive deafness11.8
19corneal dystrophy, fuchs endothelial, 711.7
20corneal dystrophy, posterior polymorphous, 111.6
21edict syndrome11.5
22hemangioma11.2
23spotted fever11.1
24lymphangiosarcoma11.1
25bullous keratopathy11.0
26hemolytic-uremic syndrome11.0
27capillary leak syndrome11.0
28alzheimer disease10.9
29aneurysmal bone cysts10.9
30macular corneal dystrophy10.9
31heme oxygenase-1 deficiency10.9
32essential iris atrophy10.9
33capillary malformations, congenital, 1, somatic, mosaic10.9
34hemangioma, capillary infantile10.8
35corneal dystrophy, congenital stromal10.8
36lung cancer10.8
37gaucher disease, type i10.6
38pulmonary hypertension, primary, 410.6
39pulmonary hypertension, familial primary, 1, with or without hht10.6
40cerebral cavernous malformations-110.6
41plasminogen activator inhibitor-1 deficiency10.6
42pulmonary hypertension, primary, 310.6
43venous malformations, multiple cutaneous and mucosal10.6
44pulmonary hypertension, primary, 210.6
45high molecular weight kininogen deficiency10.6
46carrion's disease10.6
47capillary disease10.6
48hypoxia10.5
49neuroblastoma10.4
50breast cancer10.4

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Symptoms & Phenotypes for Endotheliitis

About this section

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-359.0CXCL10, CXCL11

Drugs & Therapeutics for Endotheliitis

About this section

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ganciclovirapproved, investigationalPhase 415182410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3
2Nucleic Acid Synthesis InhibitorsPhase 44855
3Anti-Infective AgentsPhase 421402
4Ganciclovir triphosphatePhase 4151
5Antiviral AgentsPhase 49732
6TetrahydrozolinePhase 4593
7Ophthalmic SolutionsPhase 41092
8Pharmaceutical SolutionsPhase 47793

Interventional clinical trials:

idNameStatusNCT IDPhase
1Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / EndotheliitisRecruitingNCT02943057Phase 4
2Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus EndotheliitisUnknown statusNCT01359995
3Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / EndotheliitisCompletedNCT01647529

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

About this section

Anatomical Context for Endotheliitis

About this section

MalaCards organs/tissues related to Endotheliitis:

36
Endothelial, Monocytes, Brain, Lung, Neutrophil, Smooth muscle, Heart

Publications for Endotheliitis

About this section

Articles related to Endotheliitis:

(show top 50)    (show all 25444)
idTitleAuthorsYear
1
Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease. (28072843)
2017
2
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia. (27901381)
2017
3
Endothelial function impairment in STEMI patients with out-of-hospital cardiac arrest under therapeutic hypothermia treatment. (28087172)
2017
4
Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer. (28088809)
2017
5
Patients With Dry Eye Disease and Low Subbasal Nerve Density Are at High Risk for Accelerated Corneal Endothelial Cell Loss. (28060067)
2017
6
Intravascular Papillary Endothelial Hyperplasia at Foot Level: A Case Report and Literature Review. (27989349)
2017
7
Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1I+ and vascular endothelial growth factor. (28091613)
2017
8
Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease. (28069066)
2017
9
Circulating Endothelial Progenitor Cells in Crohn's Disease: An EPiC in the Making? (28078527)
2017
10
Re: Endothelial dysfunction and vascular stiffness in women with previous pregnancy complicated by early or late pre-eclampsia. R. Orabona, E. Sciatti, E. Vizzardi, I. Bonadei and A. Valcamonico. Ultrasound Obstet Gynecol 2017; 49: 116-123. (28058790)
2017
11
Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. (28087315)
2017
12
Endothelial function in children with a history of henoch schonlein purpura. (28088210)
2017
13
Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells. (27036881)
2016
14
Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein. (26707483)
2016
15
Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR. (26631725)
2016
16
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells. (26493539)
2016
17
Autosomal-Dominant Corneal Endothelial Dystrophies CHED1 and PPCD1 Are Allelic Disorders Caused by Non-coding Mutations in the Promoter of OVOL2. (26749309)
2016
18
Vascular Endothelial Growth Factor A Regulates the Secretion of Different Angiogenic Factors in Lung Cancer Cells. (26542886)
2016
19
Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor. (26819373)
2016
20
Involvement of NADPH oxidase and NF-I_B activation in CXCL1 induction by vascular endothelial growth factor in human endometrial epithelial cells of patients with adenomyosis. (27665197)
2016
21
Interleukin-1I^ mediates high glucose induced phenotypic transition in human aortic endothelial cells. (26944557)
2016
22
Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. (26831939)
2016
23
Combination Therapy of Nifedipine and Sulphonylureas Exhibits a Mutual Antagonistic Effect on the Endothelial Cell Dysfunction Induced by Hyperglycemia Linked to Vascular Disease. (27198152)
2016
24
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. (27820951)
2016
25
Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. (26387747)
2016
26
Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization. (26800564)
2016
27
Endothelial nitric oxide synthase gene polymorphism is associated with Legg-CalvAc-Perthes disease. (27168827)
2016
28
Early and Long-term Responses to Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Analysis of Protocol I Data. (27644589)
2016
29
Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats. (26842484)
2016
30
Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. (27645281)
2016
31
Vascular Endothelial Growth Factor and Diabetic Retinal Disease. (26959128)
2016
32
Tetraspanin CD151 and integrin I+6I^1 mediate platelet-enhanced endothelial colony forming cell angiogenesis. (26749288)
2016
33
A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. (26744078)
2016
34
Autonomic Neuropathy and Endothelial Dysfunction in Patients With Impaired Glucose Tolerance or Type 2 Diabetes Mellitus. (27057914)
2016
35
MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1. (26694763)
2016
36
Descemet Stripping Automated Endothelial Keratoplasty for a Patient With Combined Fuchs Dystrophy and Corneal Ectasia-A Follow-up on Vira et al's "Descemet Stripping Endothelial Keratoplasty for Treatment of Combined Fuchs Corneal Endothelial Dystrophy and Keratoconus," Cornea 2014;33: 1-5. (27583801)
2016
37
The enzyme L-isoaspartyl (D-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis. (26738492)
2016
38
Vascular endothelial growth factor polymorphism (-460 T/C) is related to hypertension-associated chronic kidney disease. (27367286)
2016
39
Ginkgo biloba extract inhibits oxidized low-density lipoprotein (oxLDL)-induced matrix metalloproteinase activation by the modulation of the lectin-like oxLDL receptor 1-regulated signaling pathway in human umbilical vein endothelial cells. (25080882)
2016
40
The relationship between circulating tissue transglutaminase, soluble fms-like tyrosine kinase-1, soluble endoglin and vascular endothelial growth factor in pre-eclampsia. (27169826)
2016
41
Interleukin-27 enhances TNF-I+-mediated activation of human coronary artery endothelial cells. (26386872)
2016
42
Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment. (28028513)
2016
43
CD44-mediated monocyte transmigration across Cryptococcus neoformans-infected brain microvascular endothelial cells is enhanced by HIV-1 gp41-I90 ectodomain. (26897523)
2016
44
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca(2+)/NFAT signaling. (26766444)
2016
45
Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats. (27010894)
2016
46
Sodium nitrite attenuates MMP-9 production by endothelial cells and may explain similar effects of atorvastatin. (26614570)
2016
47
Urinary trypsin inhibitor attenuates LPS-induced endothelial barrier dysfunction by upregulation of vascular endothelial-cadherin expression. (26681130)
2016
48
Association of vascular endothelial growth factor gene polymorphisms with ectopic pregnancy among Chinese women]. (27455016)
2016
49
Rac1 mediates HMGB1a89induced hyperpermeability in pulmonary microvascular endothelial cells via MAPK signal transduction. (26549372)
2016
50
Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction. (26850942)
2016

Variations for Endotheliitis

About this section

Expression for genes affiliated with Endotheliitis

About this section
Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

About this section

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.3CXCL10, CXCL9
2
Show member pathways
9.0CXCL10, CXCL11
3
Show member pathways
8.5CXCL10, CXCL11, CXCL9
4
Show member pathways
8.5CXCL10, CXCL11, CXCL9
5
Show member pathways
8.5CXCL10, CXCL11, CXCL9
6
Show member pathways
8.5CXCL10, CXCL11, CXCL9
7
Show member pathways
8.5CXCL10, CXCL11, CXCL9
8
Show member pathways
8.5CXCL10, CXCL11, CXCL9
98.5CXCL10, CXCL11, CXCL9
10
Show member pathways
8.5CXCL10, CXCL11, CXCL9
118.5CXCL10, CXCL11, CXCL9

GO Terms for genes affiliated with Endotheliitis

About this section

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:000989710.1CXCL10, CXCL9
2extracellular regionGO:00055769.2CXCL10, CXCL11, CXCL9
3extracellular spaceGO:00056158.5CXCL10, CXCL11, CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:005160710.1CXCL10, CXCL9
2positive regulation of leukocyte chemotaxisGO:00026909.9CXCL11, CXCL9
3cell-cell signalingGO:00072679.3CXCL10, CXCL11, CXCL9
4chemokine-mediated signaling pathwayGO:00700989.3CXCL10, CXCL11, CXCL9
5chemotaxisGO:00069359.3CXCL10, CXCL11, CXCL9
6G-protein coupled receptor signaling pathwayGO:00071869.3CXCL10, CXCL11, CXCL9
7immune responseGO:00069559.3CXCL10, CXCL11, CXCL9
8inflammatory responseGO:00069549.3CXCL10, CXCL11, CXCL9
9positive regulation of cAMP metabolic processGO:00308169.3CXCL10, CXCL11, CXCL9
10positive regulation of cAMP-mediated signalingGO:00439509.3CXCL10, CXCL11, CXCL9
11positive regulation of release of sequestered calcium ion into cytosolGO:00512819.3CXCL10, CXCL11, CXCL9
12regulation of cell proliferationGO:00421279.3CXCL10, CXCL11, CXCL9
13response to lipopolysaccharideGO:00324969.3CXCL10, CXCL11, CXCL9
14T cell chemotaxisGO:00108189.0CXCL10, CXCL11
15signal transductionGO:00071658.7CXCL10, CXCL11, CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.1CXCL10, CXCL11, CXCL9
2CXCR3 chemokine receptor bindingGO:00482489.1CXCL10, CXCL11, CXCL9
3heparin bindingGO:00082019.0CXCL10, CXCL11

Sources for Endotheliitis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet