MCID: END072
MIFTS: 47

Endotheliitis malady

Eye diseases category

Summaries for Endotheliitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

MalaCards: Endotheliitis is related to hypertension and vascular disease. An important gene associated with Endotheliitis is TNFSF15 (tumor necrosis factor (ligand) superfamily, member 15), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Rho Family GTPases. The compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial and eye, and related mouse phenotypes are cardiovascular system and cellular.

Aliases & Classifications for Endotheliitis

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48Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

endotheliitis 48


Related Diseases for Endotheliitis

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17GeneCards, 18GeneDecks
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Diseases related to Endotheliitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 876)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.4SELE, NOS3
2vascular disease31.3S1PR1, LIPG, NOS3, TEK, SELE, SELP
3breast cancer31.3FLT1, VEGFC, TYMP, FGF1, TEK
4atherosclerosis31.2STAB1, FLT1, LIPG, CDH5, FGF1, NOS3
5coronary artery disease31.1CDH5, FGF1, NOS3, TEK, SELE, SELP
6lung cancer31.1VEGFC
7ischemia31.1FLT1, VEGFC, FGF1, NOS3, TEK, SELE
8diabetic retinopathy31.1FLT1, CDH5, NOS3, TEK
9colorectal cancer31.1FLT1, VEGFC, TYMP, CDH5, TEK, SELP
10diabetes mellitus31.1NOS3, TEK, SELE, SELP
11melanoma31.1FLT1, VEGFC, CDH5, FGF1, TEK
12hepatocellular carcinoma31.1VEGFC, TYMP, FGF1, TEK
13prostate cancer31.1FLT1, VEGFC, FGF1, NOS3, TEK
14pancreatitis31.0SELP
15sarcoma31.0TEK, FLT1
16leukemia31.0TEK, FGF1, FLT1
17arthritis31.0FLT1, FGF1, TEK, SELE
18myocardial infarction31.0CDH5, FGF1, NOS3, SELP
19adenocarcinoma30.9VEGFC, TYMP, CDH5, FGF1, TEK
20rheumatoid arthritis30.9FLT1, TYMP, TEK, SELE, SELP
21kaposi's sarcoma30.9SELE, TEK, FGF1, VEGFC
22ovarian cancer30.9S1PR1, VEGFC, TYMP, CDH5, FGF1, TEK
23colon cancer30.9SELP, SELE, TEK, TYMP, FLT1
24hepatitis30.8TYMP
25obesity30.8SELE, NOS3, LIPG, FLT1
26endometriosis30.8FLT1, TYMP, TEK
27pancreatic cancer30.8FGF1, TYMP, VEGFC
28pre-eclampsia30.8FLT1
29hemangioma30.8TEK
30type 2 diabetes mellitus30.8SELP, SELE, NOS3, TYMP
31age related macular degeneration30.8FLT1
32proliferative diabetic retinopathy30.8SELP, FLT1
33acute myocardial infarction30.8CDH5, TEK, SELE, SELP
34peritonitis30.7SELP
35vasculitis30.7SELP, SELE
36kawasaki disease30.6SELE
37psoriasis30.6FLT1, NOS3, TEK, SELE, SELP
38non-small cell lung carcinoma30.5FLT1, VEGFC, TYMP, CDH5, TEK
39retinopathy of prematurity30.5FLT1
40arteriosclerosis30.5FGF1, NOS3
41peripheral vascular disease30.5SELE, SELP
42multiple sclerosis30.5S1PR1, CDH5
43malignant glioma30.5S1PR1, FLT1, TYMP, CDH5, FGF1, TEK
44hyperhomocysteinemia30.5SELP, SELE, NOS3
45antiphospholipid syndrome30.4SELP, SELE
46inflammatory bowel disease30.4TNFSF15, TEK, SELE, SELP
47endometrial carcinoma30.4VEGFC, TYMP, TEK
48proteinuria30.4TEK, NOS3, FLT1
49thyroid cancer30.4VEGFC, TEK
50bladder carcinoma30.4FGF1, TYMP

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to endotheliitis

Clinical Features for Endotheliitis

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Drugs & Therapeutics for Endotheliitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Endotheliitis

Drug clinical trials:

Search ClinicalTrials for Endotheliitis

Search NIH Clinical Center for Endotheliitis

Search CenterWatch for Endotheliitis

Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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32MalaCards
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MalaCards organs/tissues related to Endotheliitis:

32
Endothelial, Eye

Animal Models for Endotheliitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Endotheliitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538514.2SELP, S1PR1, S1PR3, STAB1, FLT1, LIPG
2MP:000538414.1FLT1, TNFSF15, S1PR3, S1PR1, COL8A2, ANTXR1
3MP:000538713.8FLT1, SCARF1, TNFSF15, S1PR3, S1PR1, VEGFC
4MP:000537613.8LIPG, FLT1, STAB1, S1PR3, S1PR1, VEGFC
5MP:001076813.7FLT1, STAB1, S1PR4, S1PR3, S1PR1, VEGFC
6MP:000539713.2S1PR1, S1PR4, TNFSF15, FLT1, CDH5, FGF1
7MP:000363112.9S1PR3, S1PR4, FLT1, TYMP, FGF1, NOS3
8MP:000287312.5S1PR1, SCARF1, STAB1, FLT1, CDH5, FGF1
9MP:000539112.1COL8A2, S1PR1, FLT1, CDH5, NOS3, SELE

Publications for Endotheliitis

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Genetic Variations for Endotheliitis

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Expression for genes affiliated with Endotheliitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for genes affiliated with Endotheliitis

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Sources:
51QIAGEN, 4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Endotheliitis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
12.4FLT1, PROK1, VEGFC, CDH5, FGF1, NOS3
2
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12.4COL8A2, FLT1, PROK1, VEGFC, CDH5, FGF1
312.4TEK, NOS3, FGF1, CDH5, TYMP, VEGFC
4
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12.1FLT1, PROK1, VEGFC, FGF1, NOS3, TEK
5
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12.1FLT1, PROK1, VEGFC, FGF1, NOS3, TEK
6
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12.1FLT1, PROK1, VEGFC, FGF1, NOS3, TEK
7
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11.8FLT1, VEGFC, NOS3, TEK, TNFSF15
811.8FLT1, VEGFC, FGF1, NOS3, TEK
9
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11.8FLT1, PROK1, VEGFC, FGF1, TEK
10
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11.8FLT1, PROK1, VEGFC, FGF1, TEK
11
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11.8TEK, FGF1, VEGFC, PROK1, FLT1
12
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11.8COL8A2, FLT1, PROK1, VEGFC, FGF1
13
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11.8S1PR1, FLT1, VEGFC, CDH5, NOS3
14
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11.8S1PR1, S1PR3, S1PR4, FLT1, CDH5
15
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11.6NOS3, TEK, SELE, SELP
16
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11.3NOS3, VEGFC, FLT1
1711.3TEK, NOS3, FLT1
1811.3FLT1, NOS3, TEK
1911.3SELP, SELE, TEK
2011.3S1PR4, S1PR3, S1PR1
21
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11.3S1PR4, S1PR3, S1PR1
22
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11.0FLT1, VEGFC
2310.7FGF1
24
Hide members
10.7PROK1

Compounds for genes affiliated with Endotheliitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Endotheliitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1vegf4413.9SELP, S1PR1, FLT1, PROK1, VEGFC, TYMP
2nitric oxide44 11 2415.9VEGFC, LIPG, FLT1, S1PR1, TYMP, CDH5
3lipid4413.3S1PR1, S1PR3, SCARF1, FLT1, LIPG, VEGFC
4tyrosine4413.3S1PR1, S1PR3, FLT1, VEGFC, TYMP, CDH5
5phosphatidylinositol4413.1S1PR1, S1PR3, FLT1, VEGFC, CDH5, FGF1
6oxygen44 2414.0FLT1, LIPG, VEGFC, TYMP, CDH5, FGF1
7matrigel4412.5FLT1, CDH5, FGF1, NOS3, TEK, SELE
8prostacyclin4412.5FLT1, TYMP, FGF1, NOS3, SELE, SELP
9ly2940024412.5S1PR1, VEGFC, TYMP, NOS3, SELE, SELP
10paraffin4412.5FLT1, VEGFC, TYMP, CDH5, FGF1, TEK
11genistein44 28 59 2 11 2417.5FLT1, CDH5, FGF1, NOS3, SELE, SELP
12thymidine44 2413.5S1PR1, FLT1, VEGFC, TYMP, FGF1, TEK
13ribonucleic acid4412.2FLT1, VEGFC, CDH5, FGF1, TEK
14heparin44 28 11 2415.0FLT1, LIPG, SELE, SELP
15formaldehyde44 2412.9TYMP, FGF1, SELE, SELP
16aspirin44 49 28 2414.9TYMP, NOS3, SELE, SELP
17compound 26 [pmid:16190743]2811.7S1PR1, S1PR3, S1PR4
18afd(r)2811.7S1PR1, S1PR3, S1PR4
19cholesterol44 28 11 2414.7FLT1, LIPG, FGF1, SELE, SELP
20w14659 2812.7S1PR1, S1PR3, S1PR4
21sphingosine-1-phosphate5911.7S1PR1, S1PR3, S1PR4
22cym 5442 hydrochloride5911.7S1PR1, S1PR4, S1PR3
23vpc 230195911.7S1PR4, S1PR3, S1PR1
24polysaccharide4411.7CDH5, FGF1, SELE, SELP
25fucoidan4411.7SELP, SELE, SCARF1
26sphingosine 1-phosphate28 2412.6S1PR4, S1PR3, S1PR1
27fenofibrate44 49 1113.6NOS3, SELE, SELP
28dextran sulfate4411.6SELP, SELE, FGF1
29fluvastatin44 49 28 1114.6NOS3, SELE, SELP
30pravastatin44 49 28 11 2415.5NOS3, SELE, SELP
31fc 774411.4SELE, SELP
32bx4714411.4SELP, SELE
33vpc441162811.4S1PR3, S1PR1
34jte 0135911.4S1PR1, S1PR3
354-f-glcnac4411.4SELE, SELP
36O-Sialic Acid1111.3SELE, SELP
37thiolutin5911.3SELE, SELP
38heparin sodium salt5911.3SELE, SELP
39echistatin, alpha1 isoform5911.3SELE, SELP
40rgds peptide5911.3SELE, SELP
41ac2-265911.3SELE, SELP
42slea4411.3SELP, SELE
43tyrosine sulfate4411.3SELP, SELE
44sodium chlorate4411.2SELP, FGF1
45tamoxifen44 49 28 1114.2FGF1, TYMP
46hydroxyethyl starch4411.1SELP, SELE
47quinapril44 1112.1SELP, SELE
48sele4411.0SELE, SELP
49lysophospholipid4411.0S1PR3, S1PR1
50adma4410.7SELE, NOS3

GO Terms for genes affiliated with Endotheliitis

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Sources:
16Gene Ontology
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Cellular components related to Endotheliitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588614.0SELP, S1PR1, S1PR3, S1PR4, TNFSF15, SCARF1
2extracellular spaceGO:00561512.3TNFSF15, FLT1, LIPG, VEGFC, FGF1, SELE
3integral to plasma membraneGO:00588712.1S1PR3, S1PR4, TNFSF15, STAB1, FLT1, TEK
4endocytic vesicle membraneGO:03066611.3NOS3, STAB1, SCARF1

Biological processes related to Endotheliitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:00152513.1TEK, COL8A2, S1PR1, PROK1, VEGFC, ECSCR
2positive regulation of cell proliferationGO:00828412.0S1PR3, FLT1, PROK1, VEGFC, FGF1
3blood coagulationGO:00759611.9VEGFC, NOS3, TEK, SELE, SELP
4positive regulation of angiogenesisGO:04576611.8FLT1, FGF1, NOS3, TEK
5positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.5SELP, TEK, FLT1
6positive regulation of cell divisionGO:05178111.5PROK1, VEGFC, FGF1
7inflammatory responseGO:00695411.5SELP, SELE, STAB1, S1PR3
8positive regulation of cell migrationGO:03033511.3FGF1, FLT1, S1PR1
9positive regulation of intracellular protein kinase cascadeGO:01074011.2TEK, FGF1
10positive regulation of leukocyte migrationGO:00268711.1SELP, SELE
11leukocyte tethering or rollingGO:05090111.0SELE, SELP
12leukocyte migrationGO:05090011.0TEK, SELE, SELP

Molecular functions related to Endotheliitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808311.6PROK1, VEGFC, TYMP, FGF1
2sphingosine-1-phosphate receptor activityGO:03803611.4S1PR4, S1PR3, S1PR1
3transmembrane signaling receptor activityGO:00488811.3SELE, ANTXR1, SCARF1
4oligosaccharide bindingGO:07049211.1SELP, SELE
5sialic acid bindingGO:03369110.9SELP, SELE
6low-density lipoprotein particle bindingGO:03016910.7STAB1, SCARF1

Products for genes affiliated with Endotheliitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Endotheliitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet