MCID: END072
MIFTS: 41

Endotheliitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis 56

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA137602

Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to erythema multiforme and fuchs' endothelial dystrophy. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Ganciclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include endothelial, monocytes and brain, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 72 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 966)
id Related Disease Score Top Affiliating Genes
1 erythema multiforme 28.1 CXCL10 CXCL11
2 fuchs' endothelial dystrophy 12.4
3 corneal endothelial dystrophy, autosomal recessive 12.2
4 corneal dystrophy, fuchs endothelial, 3 12.1
5 intravascular papillary endothelial hyperplasia 12.1
6 corneal dystrophy, fuchs endothelial, 1 12.1
7 iridocorneal endothelial syndrome 12.1
8 corneal dystrophy, fuchs endothelial, 6 12.1
9 corneal dystrophy, fuchs endothelial, 4 12.1
10 corneal endothelial dystrophy type 2 12.1
11 corneal dystrophy, fuchs endothelial, 8 12.0
12 corneal dystrophy, fuchs endothelial, 2 12.0
13 corneal endothelial dystrophy and perceptive deafness 12.0
14 corneal dystrophy, fuchs endothelial, 5 11.9
15 corneal dystrophy, endothelial, x-linked 11.8
16 corneal endothelial dystrophy 2, autosomal recessive 11.8
17 corneal dystrophy, fuchs endothelial, 7 11.7
18 chandler syndrome 11.6
19 corneal dystrophy, posterior polymorphous, 1 11.6
20 edict syndrome 11.5
21 hemangioma 11.1
22 spotted fever 11.1
23 lymphangiosarcoma 11.1
24 bullous keratopathy 11.0
25 hemolytic-uremic syndrome 11.0
26 moved to 122000 10.9
27 aneurysmal bone cysts 10.9
28 macular corneal dystrophy 10.9
29 heme oxygenase-1 deficiency 10.9
30 hepatic veno-occlusive disease 10.9
31 essential iris atrophy 10.9
32 capillary malformations, congenital, 1, somatic, mosaic 10.9
33 hemangioma, capillary infantile 10.8
34 corneal dystrophy, congenital stromal 10.8
35 kanzaki disease 10.8
36 lung cancer 10.8
37 gaucher disease, type i 10.6
38 pulmonary hypertension, primary, 4 10.6
39 gapo syndrome 10.6
40 pulmonary hypertension, familial primary, 1, with or without hht 10.6
41 cerebral cavernous malformations-1 10.6
42 pulmonary hypertension, primary, 3 10.6
43 venous malformations, multiple cutaneous and mucosal 10.6
44 pulmonary hypertension, primary, 2 10.6
45 high molecular weight kininogen deficiency 10.6
46 carrion's disease 10.6
47 cogan-reese syndrome 10.6
48 malignant hemangioma 10.6
49 malignant epithelioid hemangioendothelioma 10.6
50 capillary disease 10.6

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis

Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.32 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 CXCL10 CXCL11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.32 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 CXCL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.32 CXCL11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CXCL11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.32 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 CXCL10

Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
2 Anti-Infective Agents Phase 4
3 Antiviral Agents Phase 4
4 Ganciclovir triphosphate Phase 4
5 Nucleic Acid Synthesis Inhibitors Phase 4
6 Ophthalmic Solutions Phase 4
7 Pharmaceutical Solutions Phase 4
8 Tetrahydrozoline Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
2 Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis Unknown status NCT01359995
3 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Ganciclovir

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

39
Endothelial, Monocytes, Brain, Lung, Breast, Neutrophil, Smooth Muscle

Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 26022)
id Title Authors Year
1
Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease. ( 28851747 )
2017
2
Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells. ( 28408374 )
2017
3
Thioredoxin attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NADPH oxidase activity. ( 28688762 )
2017
4
Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. ( 28118661 )
2017
5
Corneal Endothelial Dystrophy Associated With Myotonic Dystrophy: A Report of 2 Cases. ( 28820792 )
2017
6
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target ofA Rapamycin Signaling and Hypoxia-Inducible Factor-1I+/Vascular Endothelial Growth Factor-C Expression. ( 28627412 )
2017
7
MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. ( 28110404 )
2017
8
Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. ( 28469167 )
2017
9
The Effect of Velvet Antler Proteins on Cardiac Microvascular Endothelial Cells Challenged with Ischemia-Hypoxia. ( 28936174 )
2017
10
Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial. ( 28709700 )
2017
11
Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3. ( 28450107 )
2017
12
Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro. ( 28538400 )
2017
13
The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis. ( 28188309 )
2017
14
The regulation of Jmjd3 upon the expression of NF-I_B downstream inflammatory genes in LPS activated vascular endothelial cells. ( 28189690 )
2017
15
Depleted nitric oxide and prostaglandin E2 levels are correlated with endothelial dysfunction in I^-thalassemia/HbE patients. ( 28474291 )
2017
16
Moderate-dose atorvastatin improves arterial endothelial function in patients with angina pectoris and normal coronary angiogram: a pilot study. ( 28721151 )
2017
17
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. ( 28886202 )
2017
18
Carotid Artery Stiffness, Digital Endothelial Function, and Coronary Calcium in Patients with Essential Thrombocytosis, Free of Overt Atherosclerotic Disease. ( 28740456 )
2017
19
Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury. ( 28953090 )
2017
20
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. ( 28751712 )
2017
21
Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis. ( 28007913 )
2017
22
Soluble fms-Like Tyrosine Kinase 1 as a Link Between Angiogenesis and Endothelial Dysfunction in Pediatric Patients With I^-Thalassemia Intermedia. ( 28301910 )
2017
23
Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario. ( 28384867 )
2017
24
Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report. ( 28357092 )
2017
25
Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis. ( 28945793 )
2017
26
Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid. ( 28131839 )
2017
27
Human microvascular endothelial cell promotes the development of dorsal root ganglion neurons via BDNF pathway in a co-culture system. ( 28394221 )
2017
28
Metalloproteinase-9 contributes to endothelial dysfunction in atherosclerosis via protease activated receptor-1. ( 28166283 )
2017
29
Soluble endoglin modulates the pro-inflammatory mediators NF-I_B and IL-6 in cultured human endothelial cells. ( 28336397 )
2017
30
MALAT1 Modulates TGF-I^1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145. ( 28535533 )
2017
31
Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study. ( 28361419 )
2017
32
O-GlcNAc modification of Sp1 mediates hyperglycaemia-induced ICAM-1 up-regulation in endothelial cells. ( 28104396 )
2017
33
Long-Term Endothelial Cell Loss in Patients with Artisan Myopia and Artisan Toric Phakic Intraocular Lenses: 5- and 10-Year Results. ( 28935401 )
2017
34
Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis. ( 27848074 )
2017
35
PKC mediated phosphorylation of TIMAP regulates PP1c activity and endothelial barrier function. ( 27939168 )
2017
36
Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction. ( 28126510 )
2017
37
Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity. ( 27528462 )
2017
38
Effects of acute exercise on endothelial function in abdominal aortic aneurysm patients. ( 28939648 )
2017
39
Interface Scopulariopsis gracilis fungal keratitis following Descemet's stripping automated endothelial keratoplasty (DSAEK) with a contaminated graft. ( 28900769 )
2017
40
Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes. ( 28403223 )
2017
41
Correction: Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. ( 28938702 )
2017
42
Peroxisome Proliferator-Activated Receptor I^ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. ( 27612006 )
2017
43
Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease: The iPOWER Study. ( 28942444 )
2017
44
Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process. ( 28408355 )
2017
45
Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1. ( 28504698 )
2017
46
Endothelial dysfunction in patients with Buerger disease. ( 28860792 )
2017
47
Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro. ( 28150318 )
2017
48
Infectious crystalline keratopathy after DescemetAca8-a8cs stripping endothelial keratoplasty. ( 28619977 )
2017
49
Endothelial Cells Promote Formation of Medulloblastoma Stem-Like Cells via Notch Pathway Activation. ( 28856557 )
2017
50
Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model. ( 28744465 )
2017

Variations for Endotheliitis

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 CXCL10 CXCL11 CXCL9
2
Show member pathways
12.94 CXCL10 CXCL11 CXCL9
3
Show member pathways
12.79 CXCL10 CXCL11 CXCL9
4
Show member pathways
12.78 CXCL10 CXCL11 CXCL9
5
Show member pathways
12.64 CXCL10 CXCL11 CXCL9
6
Show member pathways
12.3 CXCL10 CXCL11 CXCL9
7
Show member pathways
12.21 CXCL10 CXCL11 CXCL9
8
Show member pathways
11.65 CXCL10 CXCL11
9
Show member pathways
11.22 CXCL10 CXCL11 CXCL9
10 10.89 CXCL10 CXCL9
11 10.56 CXCL10 CXCL11 CXCL9
12 10.33 CXCL10 CXCL11 CXCL9

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.13 CXCL10 CXCL11 CXCL9
2 external side of plasma membrane GO:0009897 8.62 CXCL10 CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.73 CXCL10 CXCL11 CXCL9
2 G-protein coupled receptor signaling pathway GO:0007186 9.71 CXCL10 CXCL11 CXCL9
3 immune response GO:0006955 9.7 CXCL10 CXCL11 CXCL9
4 inflammatory response GO:0006954 9.69 CXCL10 CXCL11 CXCL9
5 cell-cell signaling GO:0007267 9.67 CXCL10 CXCL11 CXCL9
6 regulation of cell proliferation GO:0042127 9.65 CXCL10 CXCL11 CXCL9
7 response to lipopolysaccharide GO:0032496 9.61 CXCL10 CXCL11 CXCL9
8 chemotaxis GO:0006935 9.58 CXCL10 CXCL11 CXCL9
9 defense response to virus GO:0051607 9.55 CXCL10 CXCL9
10 defense response GO:0006952 9.54 CXCL10 CXCL11 CXCL9
11 chemokine-mediated signaling pathway GO:0070098 9.5 CXCL10 CXCL11 CXCL9
12 positive regulation of leukocyte chemotaxis GO:0002690 9.46 CXCL11 CXCL9
13 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.43 CXCL10 CXCL11 CXCL9
14 positive regulation of cAMP metabolic process GO:0030816 9.33 CXCL10 CXCL11 CXCL9
15 T cell chemotaxis GO:0010818 9.13 CXCL10 CXCL11 CXCL9
16 positive regulation of cAMP-mediated signaling GO:0043950 8.8 CXCL10 CXCL11 CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CXCL10 CXCL11 CXCL9
2 heparin binding GO:0008201 9.26 CXCL10 CXCL11
3 chemokine activity GO:0008009 9.13 CXCL10 CXCL11 CXCL9
4 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL10 CXCL11 CXCL9

Sources for Endotheliitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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