Endotoxin Hyporesponsiveness malady

Summaries for Endotoxin Hyporesponsiveness

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MalaCards: Endotoxin Hyporesponsiveness is related to periodontal disease and leprosy. An important gene associated with Endotoxin Hyporesponsiveness is TLR4 (toll-like receptor 4), and among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include monocytes, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Endotoxin Hyporesponsiveness

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Aliases & Descriptions:

endotoxin hyporesponsiveness 48 63

Related Diseases for Endotoxin Hyporesponsiveness

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18GeneCards, 19GeneDecks
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Diseases related to Endotoxin Hyporesponsiveness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1periodontal disease10.1TNF
3colorectal cancer10.1RPS27A
4degenerative disc disease10.1IL1B
5skin disease10.1IL1B
6spondylarthropathy10.1TLR4, TNF
7invasive aspergillosis10.0TLR4, TLR2
8pouchitis10.0TLR2, TLR4
9melioidosis10.0TLR2, TLR4
10alcoholic hepatitis10.0TNF, RPS27A
11filariasis10.0TLR4, TLR2
12neisseria meningitidis infection10.0TLR2, TLR4
13malaria10.0TNF, TLR2
14ankylosing spondylitis10.0TLR4, TNF
15aspergillosis10.0TLR2, TLR4
16keratitis10.0TLR2, TLR4
17malt lymphoma10.0TLR2, TLR4
18atopy10.0TLR4, TLR2
19blau syndrome10.0TNF, IL1B
20aids dementia complex10.0IL1B, TNF
21familial mediterranean fever10.0IL1B, TNF
22arthritis10.0IL1B, TNF
23interstitial lung disease10.0IL1B, TNF
24cerebral malaria10.0IL1B, TNF
25toxic shock syndrome10.0TNF, IL1B
26allergic asthma10.0TLR2, TLR4
27adult respiratory distress syndrome10.0TNF, IL1B
28bacterial meningitis10.0IL1B, TLR2
29respiratory failure10.0TNF, IL1B
30otitis media10.0IL1B, TLR2
31arthropathy10.0TNF, IL1B
32insulin resistance10.0TLR4, RPS27A, TNF
33hepatitis c10.0TLR2, TLR4, TNF
34atopic dermatitis10.0TLR4, TNF, TLR2
35meningitis10.0TLR2, IL1B
36sarcoidosis10.0TNF, IL1B
37encephalitis10.0IL1B, TLR2
38pulmonary disease, chronic obstructive10.0TNF, TLR2
39monocytic leukemia10.0TLR4, IL1B, TNF
40primary hyperoxaluria10.0IL1B, TNF
41endometriosis10.0RPS27A, IL1B
42hypersensitivity reaction type ii disease10.0TLR4, IL1B, TNF
43galactosemia10.0TLR4, TNF, IL1B
44congenital heart disease10.0IL1B, TNF, TLR4
45mastitis10.0TLR2, TLR4, IL1B
46periodontitis10.0IL1B, TLR4, TLR2
47inflammatory bowel disease10.0IL1B, TLR2, TLR4
48gastritis10.0IL1B, TLR4, TLR2
49psoriatic arthritis10.0TLR2, TNF, IL1B
50peritonitis10.0TNF, TLR2, IL1B

Graphical network of the top 20 diseases related to Endotoxin Hyporesponsiveness:

Diseases related to endotoxin hyporesponsiveness

Symptoms for Endotoxin Hyporesponsiveness

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Drugs & Therapeutics for Endotoxin Hyporesponsiveness

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Endotoxin Hyporesponsiveness

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Anatomical Context for Endotoxin Hyporesponsiveness

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MalaCards organs/tissues related to Endotoxin Hyporesponsiveness:


Animal Models for Endotoxin Hyporesponsiveness or affiliated genes

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MGI Mouse Phenotypes related to Endotoxin Hyporesponsiveness:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8TNF, TLR4, TLR2
2MP:00020068.2IL1B, TNF, TLR4, TLR2
3MP:00053908.1TLR2, TLR4, TNF, IL1B
4MP:00053858.1TLR2, TLR4, TNF, IL1B
5MP:00053878.1IL1B, TNF, TLR4, TLR2
6MP:00053977.8TLR2, TLR4, TNF, IL1B

Publications for Endotoxin Hyporesponsiveness

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Articles related to Endotoxin Hyporesponsiveness:

N-Acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness. (15733769)
Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. (12406900)
Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery. (11323370)
Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium. (11396812)
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. (10835634)

Variations for Endotoxin Hyporesponsiveness

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Expression for genes affiliated with Endotoxin Hyporesponsiveness

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endotoxin Hyporesponsiveness

Search GEO for disease gene expression data for Endotoxin Hyporesponsiveness.

Pathways for genes affiliated with Endotoxin Hyporesponsiveness

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51PathCards, 56Reactome, 31KEGG, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 13EMD Millipore, 58SinoBiological, 55R&D Systems, 62Tocris Bioscience, 5Cell Signaling Technology
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Pathways related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
Show member pathways
9.5RPS27A, TLR4
Show member pathways
9.4RPS27A, TNF
39.4TLR4, TLR2
Show member pathways
9.4TLR4, TLR2
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9.3TNF, TLR2
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9.2IL1B, TLR4
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9.1RPS27A, IL1B
89.1IL1B, TNF
Show member pathways
Serotonin Transporter Activity39
9.1TNF, IL1B
109.1IL1B, TNF
119.1IL1B, TNF
129.1IL1B, TNF
Show member pathways
9.1IL1B, TNF
149.1TNF, IL1B
159.1IL1B, TNF
169.1IL1B, TNF
179.1TNF, IL1B
Show member pathways
thioredoxin pathway39
9.1TNF, IL1B
199.1TNF, IL1B
209.0TLR2, IL1B
218.9TNF, TLR4, TLR2
228.9TLR2, TLR4, TNF
Show member pathways
8.9TLR2, TLR4, TNF
248.7TLR4, TNF, IL1B
Show member pathways
8.7IL1B, TNF, TLR4
268.7IL1B, TNF, TLR4
278.7TLR4, TNF, IL1B
Show member pathways
8.7TLR4, TNF, IL1B
Show member pathways
Immune response MIF in innate immunity response61
8.7TLR4, TNF, IL1B
308.7IL1B, TNF, TLR4
Show member pathways
8.6IL1B, TLR4, TLR2
Show member pathways
8.6IL1B, TLR4, TLR2
Show member pathways
8.1IL1B, TNF, TLR4, TLR2
348.1IL1B, TNF, TLR4, TLR2
358.1TLR2, TLR4, TNF, IL1B
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.1TLR2, TLR4, TNF, IL1B
Show member pathways
IL27-mediated signaling events39
8.1TLR2, TLR4, TNF, IL1B
388.1TLR2, TLR4, TNF, IL1B
398.1TLR2, TLR4, TNF, IL1B
408.1TLR2, TLR4, TNF, IL1B
Show member pathways
8.1TLR2, TLR4, TNF, IL1B
Show member pathways
8.1IL1B, TNF, TLR4, TLR2
Show member pathways
8.1TLR2, TLR4, TNF, IL1B
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.1TLR2, TLR4, TNF, IL1B
Show member pathways
8.1IL1B, TNF, TLR4, TLR2
468.1IL1B, TNF, TLR4, TLR2
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.1TLR2, TLR4, TNF, IL1B
488.1IL1B, TNF, TLR4, TLR2

Compounds for genes affiliated with Endotoxin Hyporesponsiveness

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46Novoseek, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1arabinogalactan469.7TLR4, TLR2
2diaminopimelic acid469.7TLR4, TLR2
3loxoribine46 3010.6TLR4, TLR2
4poly(i:c)629.6TLR2, TLR4
5pam3csk4629.6TLR4, TLR2
6pam2csk4629.6TLR2, TLR4
7d-galactosamine469.6TNF, TLR4
8glucuronoxylomannan469.5TLR4, TLR2
9chloroquine46 3 52 30 1213.3RPS27A, TNF, TLR4
10zymosan469.3TNF, TLR4, TLR2
11imiquimod46 62 30 1212.3TLR2, TLR4, TNF
12palmitate469.1TLR4, RPS27A, TLR2
13diphenyleneiodonium469.0IL1B, TNF, TLR4
14infliximab46 52 1211.0TLR4, TNF, IL1B
15c2ceramide469.0IL1B, TLR4, TNF
16muramyl dipeptide46 3010.0TLR4, TLR2, IL1B
17tpck469.0RPS27A, TNF, IL1B
18hbd2469.0IL1B, TLR2, TLR4
19pdtc469.0IL1B, TNF, TLR4
20flagellin46 3010.0IL1B, TLR4, TLR2
21leukotriene b446 62 2510.8IL1B, TLR2, TNF
22sp 60012546 629.8IL1B, TNF, TLR2
23tacrolimus46 52 1210.8TLR4, RPS27A, TNF, TLR2
24troglitazone46 30 62 1211.7IL1B, RPS27A, TNF
25cyclosporin a46 30 6210.7TLR4, TLR2, RPS27A, TNF
26h2o2468.6TNF, RPS27A, TLR2, TLR4
27mg 13246 629.6RPS27A, IL1B, TNF
28herbimycin a46 629.6RPS27A, IL1B, TNF
29simvastatin46 52 62 30 25 1213.6TNF, TLR4, TLR2
30tgf beta1468.6TLR4, IL1B, TNF
31n acetylcysteine468.5RPS27A, TNF, IL1B, TLR4
32polymyxin b468.5TLR4, TNF, TLR2, IL1B
33lipoteichoic acid468.5IL1B, TNF, TLR4, TLR2
34polyinosinic-polycytidylic acid468.5IL1B, TLR2, TLR4, TNF
35poly(i-c)468.5TNF, IL1B, TLR4, TLR2
36il 10468.5TLR2, IL1B, TLR4, TNF
37peptidoglycan46 309.5TLR4, TNF, IL1B, TLR2
38ccl346 309.5TLR2, TLR4, TNF, IL1B
39endotoxin468.5TNF, TLR4, TLR2, IL1B
40calcitriol46 62 25 1211.5TLR2, TLR4, IL1B, TNF
41rantes468.4TLR2, TLR4, IL1B, TNF
42sb 20358046 629.4IL1B, TLR2, TNF, TLR4
43histamine46 30 2510.4TLR4, IL1B, TLR2, TNF
44superoxide46 259.4TLR2, TLR4, TNF, IL1B
45actinomycin d468.0IL1B, RPS27A, TLR4, TNF, TLR2
46pge2468.0TLR2, TLR4, TNF, IL1B, RPS27A
47cycloheximide468.0TNF, RPS27A, TLR4, TLR2, IL1B
48dexamethasone46 52 30 1210.9TLR2, RPS27A, IL1B, TNF, TLR4
49vegf467.9TLR2, TNF, IL1B, TLR4, RPS27A
50retinoic acid46 258.9TLR4, TLR2, IL1B, RPS27A, TNF

GO Terms for genes affiliated with Endotoxin Hyporesponsiveness

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17Gene Ontology
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Cellular components related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9TNF, TLR4, TLR2

Biological processes related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:0454169.9TLR4, TNF
2positive regulation of macrophage cytokine productionGO:0609079.8TLR4, TLR2
3negative regulation of interleukin-6 productionGO:0327159.8TNF, TLR4
4cellular response to lipoteichoic acidGO:0712239.8TLR4, TLR2
5negative regulation of interleukin-17 productionGO:0327009.7TLR2, TLR4
6positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR4, TLR2
7positive regulation of interleukin-18 productionGO:0327419.7TLR2, TNF
8positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR2, TLR4
9I-kappaB phosphorylationGO:0072529.7TLR2, TLR4
10positive regulation of interleukin-10 productionGO:0327339.7TLR4, TLR2
11positive regulation of interferon-beta productionGO:0327289.7TLR2, TLR4
12negative regulation of growth of symbiont in hostGO:0441309.6TNF, TLR2
13positive regulation of interleukin-12 productionGO:0327359.6TLR4, TLR2
14positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5TNF, IL1B
15sequestering of triglycerideGO:0307309.5TNF, IL1B
16positive regulation of cytokine secretionGO:0507159.5TNF, TLR2
17positive regulation of fever generationGO:0316229.5IL1B, TNF
18positive regulation of heterotypic cell-cell adhesionGO:0341169.5IL1B, TNF
19positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL1B
20regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.5IL1B, TNF
21positive regulation of membrane protein ectodomain proteolysisGO:0510449.4IL1B, TNF
22negative regulation of lipid catabolic processGO:0509959.4TNF, IL1B
23positive regulation of tumor necrosis factor productionGO:0327609.4TLR4, TLR2
24positive regulation of chemokine productionGO:0327229.3TNF, TLR4, TLR2
25positive regulation of mitosisGO:0458409.3TNF, IL1B
26toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.3TLR2, TLR4, RPS27A
27toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.3TLR2, TLR4, RPS27A
28toll-like receptor 2 signaling pathwayGO:0341349.3RPS27A, TLR4, TLR2
29MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3RPS27A, TLR4, TLR2
30toll-like receptor 4 signaling pathwayGO:0341429.3TLR2, TLR4, RPS27A
31toll-like receptor signaling pathwayGO:0022249.3TLR2, TLR4, RPS27A
32protein kinase B signalingGO:0434919.2IL1B, TNF
33defense response to Gram-positive bacteriumGO:0508309.2TNF, TLR2
34negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.2IL1B, TNF
35positive regulation of interferon-gamma productionGO:0327299.1TLR4, TNF, IL1B
36positive regulation of JNK cascadeGO:0463309.1IL1B, TNF, TLR4
37positive regulation of interleukin-8 productionGO:0327579.0TLR2, TLR4, IL1B
38cellular response to organic cyclic compoundGO:0714078.8IL1B, TNF
39inflammatory responseGO:0069548.7IL1B, TNF, TLR2
40immune responseGO:0069558.7IL1B, TLR4, TLR2
41activation of MAPK activityGO:0001878.6TLR4, TNF, IL1B, RPS27A
42positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.6TLR4, TNF, IL1B, RPS27A
43negative regulation of cell proliferationGO:0082858.5TLR2, TNF, IL1B
44positive regulation of NF-kappaB import into nucleusGO:0423468.5IL1B, TNF, TLR4, TLR2
45lipopolysaccharide-mediated signaling pathwayGO:0316638.5IL1B, TNF, TLR4, TLR2
46positive regulation of nitric oxide biosynthetic processGO:0454298.5TLR2, TLR4, TNF, IL1B
47positive regulation of interleukin-6 productionGO:0327558.5IL1B, TNF, TLR4, TLR2
48apoptotic processGO:0069158.4TLR2, TNF, IL1B, RPS27A
49positive regulation of NF-kappaB transcription factor activityGO:0510928.0TLR2, TLR4, TNF, IL1B, RPS27A
50positive regulation of transcription from RNA polymerase II promoterGO:0459448.0RPS27A, IL1B, TNF, TLR4, TLR2

Molecular functions related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR4, TLR2
2lipopolysaccharide receptor activityGO:0018759.1TLR4, TLR2

Products for genes affiliated with Endotoxin Hyporesponsiveness

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Sources for Endotoxin Hyporesponsiveness

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27ICD10 via Orphanet
37MESH via Orphanet
49OMIM via Orphanet
60SNOMED-CT via Orphanet
64UMLS via Orphanet