MCID: END048
MIFTS: 28

Endotoxin Hyporesponsiveness malady

Summaries for Endotoxin Hyporesponsiveness

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33MalaCards
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MalaCards: Endotoxin Hyporesponsiveness is related to acute pancreatitis and thrombocytopenia. An important gene associated with Endotoxin Hyporesponsiveness is TLR4 (toll-like receptor 4), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Phagocytosis of Microbes. The compounds cycloheximide and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include lung and monocytes, and related mouse phenotypes are skeleton and tumorigenesis.

Aliases & Classifications for Endotoxin Hyporesponsiveness

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47OMIM, 61UMLS
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Aliases & Descriptions:

endotoxin hyporesponsiveness 47 61


Related Diseases for Endotoxin Hyporesponsiveness

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endotoxin Hyporesponsiveness:



Diseases related to endotoxin hyporesponsiveness

Clinical Features for Endotoxin Hyporesponsiveness

Drugs & Therapeutics for Endotoxin Hyporesponsiveness

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Endotoxin Hyporesponsiveness

Drug clinical trials:

Search ClinicalTrials for Endotoxin Hyporesponsiveness

Search NIH Clinical Center for Endotoxin Hyporesponsiveness

Search CenterWatch for Endotoxin Hyporesponsiveness

Genetic Tests for Endotoxin Hyporesponsiveness

Anatomical Context for Endotoxin Hyporesponsiveness

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33MalaCards
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MalaCards organs/tissues related to Endotoxin Hyporesponsiveness:

33
Lung, Monocytes

Animal Models for Endotoxin Hyporesponsiveness or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Endotoxin Hyporesponsiveness:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7IL1B
2MP:00020068.8IL1B, TNF

Publications for Endotoxin Hyporesponsiveness

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51PubMed
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Articles related to Endotoxin Hyporesponsiveness:

idTitleAuthorsYear
1
N-Acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness. (15733769)
2005
2
Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. (12406900)
2003
3
Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery. (11323370)
2001
4
Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium. (11396812)
2001
5
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. (10835634)
2000
6
Inhibition of nitric oxide synthase prevents hyporesponsiveness to inhaled nitric oxide in lungs from endotoxin-challenged rats. (10422947)
1999
7
Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections. (9103466)
1997

Genetic Variations for Endotoxin Hyporesponsiveness

Expression for genes affiliated with Endotoxin Hyporesponsiveness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endotoxin Hyporesponsiveness

Search GEO for disease gene expression data for Endotoxin Hyporesponsiveness.

Pathways for genes affiliated with Endotoxin Hyporesponsiveness

Sources:
12EMD Millipore, 52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database, 56SinoBiological, 53R&D Systems, 60Tocris Bioscience, 4Cell Signaling Technology
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Pathways related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, TLR4
29.5TLR2, TLR4
3
Hide members
9.5TLR2, TLR4
49.5TLR4, TNF
5
Hide members
9.4TLR4, RPS27A
6
Hide members
9.3TNF, RPS27A
79.1IL1B, TLR2
89.1IL1B, TNF
99.1TNF, IL1B
109.1IL1B, TNF
119.1IL1B, TNF
129.1IL1B, TNF
139.1TNF, IL1B
14
Hide members
9.0IL1B, RPS27A
159.0TNF, TLR2, TLR4
16
Hide members
9.0TLR4, TLR2, TNF
17
Hide members
8.9RPS27A, TLR4, TLR2
18
Hide members
8.7IL1B, TLR2, TLR4
19
Hide members
8.7TLR4, TNF, IL1B
208.7TLR4, TNF, IL1B
218.7IL1B, TNF, TLR4
228.7IL1B, TNF, TLR4
23
Hide members
8.7IL1B, TNF, TLR4
248.7TLR4, TNF, IL1B
25
Hide members
8.5IL1B, TNF, RPS27A
268.2TLR4, TLR2, TNF, IL1B
278.2TLR4, TLR2, TNF, IL1B
28
Immune response Bacterial infections in normal airways
Hide members
8.2TLR4, TLR2, TNF, IL1B
29
Hide members
8.2TLR4, TLR2, TNF, IL1B
308.2TLR4, TLR2, TNF, IL1B
318.2TLR4, TLR2, TNF, IL1B
32
Hide members
8.2TLR4, TLR2, TNF, IL1B
33
Hide members
8.2TLR4, TLR2, TNF, IL1B
34
Hide members
8.2TLR4, TLR2, TNF, IL1B
358.2TLR4, TLR2, TNF, IL1B
36
Hide members
8.2TLR4, TLR2, TNF, IL1B
37
Hide members
8.2TLR4, TLR2, TNF, IL1B
38
Hide members
8.2IL1B, TNF, TLR2, TLR4
39
Hide members
8.2IL1B, TNF, TLR2, TLR4
408.2IL1B, TNF, TLR2, TLR4
418.2IL1B, TNF, TLR2, TLR4
42
Hide members
8.1IL1B, TLR2, TLR4, RPS27A

Compounds for genes affiliated with Endotoxin Hyporesponsiveness

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.4TLR2
2cyclosporin a45 29 6012.2RPS27A
3h2o24510.1RPS27A
4diphenyleneiodonium4510.0IL1B
5dexamethasone45 50 29 1112.9TLR2, TLR4
6arabinogalactan459.9TLR4, TLR2
7diaminopimelic acid459.8TLR4, TLR2
8pam2csk4609.8TLR4, TLR2
9loxoribine45 2910.8TLR2, TLR4
10poly(i:c)609.8TLR2, TLR4
11pam3csk4609.8TLR2, TLR4
12tacrolimus45 50 1111.8RPS27A, TLR2
13glucuronoxylomannan459.7TLR2, TLR4
14d-galactosamine459.7TNF, TLR4
15resiquimod45 6010.6TLR4, TLR2
16superoxide45 2410.5IL1B, TNF
17zymosan459.4TNF, TLR4, TLR2
18imiquimod45 29 60 1112.4TNF, TLR2, TLR4
19chloroquine45 2 50 29 1113.2TNF, TLR4, RPS27A
20n,n-dimethylsphingosine45 6010.1TNF, IL1B
21muramyl dipeptide45 2910.1IL1B, TLR4, TLR2
22hbd2459.1IL1B, TLR4, TLR2
23flagellin45 2910.1TLR4, TLR2, IL1B
24palmitate459.1TLR4, RPS27A, TLR2
25infliximab45 50 1111.0TLR4, TNF, IL1B
26c2ceramide459.0TNF, TLR4, IL1B
27pdtc459.0TLR4, IL1B, TNF
28tpck458.9RPS27A, TNF, IL1B
29leukotriene b445 60 2410.9IL1B, TNF, TLR2
30simvastatin45 50 60 29 11 2413.9TNF, TLR2, TLR4
31sp 60012545 609.9TLR2, TNF, IL1B
32tgf beta1458.7IL1B, TNF, TLR4
33troglitazone45 29 60 1111.7TNF, IL1B, RPS27A
34polymyxin b458.6IL1B, TNF, TLR2, TLR4
35lipoteichoic acid458.6TLR4, TLR2, TNF, IL1B
36polyinosinic-polycytidylic acid458.6TLR2, IL1B, TNF, TLR4
37poly(i-c)458.6IL1B, TNF, TLR2, TLR4
38il 10458.6IL1B, TNF, TLR4, TLR2
39peptidoglycan45 299.6IL1B, TNF, TLR4, TLR2
40ccl345 299.6TLR2, IL1B, TNF, TLR4
41mg 13245 609.6TNF, RPS27A, IL1B
42calcitriol45 60 11 2411.6IL1B, TLR4, TLR2, TNF
43rantes458.5TLR4, IL1B, TNF, TLR2
44sb 20358045 609.5TLR2, TLR4, IL1B, TNF
45histamine45 29 2410.5TNF, IL1B, TLR2, TLR4
46n acetylcysteine458.4TNF, IL1B, TLR4, RPS27A
47herbimycin a45 609.2TNF, IL1B, RPS27A
48actinomycin d458.0IL1B, TNF, TLR2, RPS27A, TLR4
49vegf457.9IL1B, TLR2, RPS27A, TNF, TLR4
50retinoic acid45 248.9IL1B, TNF, RPS27A, TLR4, TLR2

GO Terms for genes affiliated with Endotoxin Hyporesponsiveness

Sources:
16Gene Ontology
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Cellular components related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0TNF, TLR2, TLR4

Biological processes related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage cytokine productionGO:0609079.9TLR2, TLR4
2cellular response to lipoteichoic acidGO:0712239.9TLR2, TLR4
3positive regulation of interleukin-8 biosynthetic processGO:0454169.9TLR4, TNF
4negative regulation of interleukin-17 productionGO:0327009.9TLR4, TLR2
5positive regulation of tumor necrosis factor biosynthetic processGO:0425359.8TLR2, TLR4
6positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.8TLR4, TLR2
7I-kappaB phosphorylationGO:0072529.8TLR4, TLR2
8negative regulation of interleukin-6 productionGO:0327159.8TLR4, TNF
9positive regulation of interferon-beta productionGO:0327289.8TLR2, TLR4
10positive regulation of interleukin-12 productionGO:0327359.8TLR2, TLR4
11negative regulation of growth of symbiont in hostGO:0441309.7TNF, TLR2
12positive regulation of cytokine secretionGO:0507159.7TLR2, TNF
13positive regulation of tumor necrosis factor productionGO:0327609.6TLR2, TLR4
14sequestering of triglycerideGO:0307309.6IL1B, TNF
15positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, TNF
16positive regulation of heterotypic cell-cell adhesionGO:0341169.5TNF, IL1B
17positive regulation of fever generationGO:0316229.5IL1B, TNF
18positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL1B
19regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.5IL1B, TNF
20positive regulation of membrane protein ectodomain proteolysisGO:0510449.5IL1B, TNF
21negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
22defense response to Gram-positive bacteriumGO:0508309.4TLR2, TNF
23positive regulation of chemokine productionGO:0327229.4TNF, TLR2, TLR4
24negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, TNF
25positive regulation of mitosisGO:0458409.4IL1B, TNF
26cellular response to organic cyclic compoundGO:0714079.3IL1B, TNF
27JNK cascadeGO:0072549.3TNF, RPS27A
28I-kappaB kinase/NF-kappaB cascadeGO:0072499.3TLR4, RPS27A
29toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.3RPS27A, TLR4, TLR2
30toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.3RPS27A, TLR4, TLR2
31toll-like receptor 2 signaling pathwayGO:0341349.3TLR2, TLR4, RPS27A
32protein kinase B signaling cascadeGO:0434919.3IL1B, TNF
33MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3RPS27A, TLR4, TLR2
34toll-like receptor 4 signaling pathwayGO:0341429.3RPS27A, TLR4, TLR2
35toll-like receptor signaling pathwayGO:0022249.3RPS27A, TLR4, TLR2
36positive regulation of inflammatory responseGO:0507299.2TLR2, TLR4
37positive regulation of interleukin-8 productionGO:0327579.1TLR4, TLR2, IL1B
38positive regulation of interferon-gamma productionGO:0327299.1IL1B, TNF, TLR4
39positive regulation of JNK cascadeGO:0463309.1TLR4, TNF, IL1B
40inflammatory responseGO:0069548.8TLR2, TNF, IL1B
41immune responseGO:0069558.7IL1B, TLR2, TLR4
42positive regulation of NF-kappaB import into nucleusGO:0423468.6TLR4, TLR2, TNF, IL1B
43lipopolysaccharide-mediated signaling pathwayGO:0316638.6IL1B, TNF, TLR2, TLR4
44positive regulation of nitric oxide biosynthetic processGO:0454298.6TLR4, TLR2, TNF, IL1B
45positive regulation of interleukin-6 productionGO:0327558.6IL1B, TNF, TLR2, TLR4
46activation of MAPK activityGO:0001878.5RPS27A, TLR4, TNF, IL1B
47positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.5RPS27A, TLR4, TNF, IL1B
48apoptotic processGO:0069158.3RPS27A, TLR2, TNF, IL1B
49positive regulation of NF-kappaB transcription factor activityGO:0510928.0IL1B, TNF, TLR2, TLR4, RPS27A
50positive regulation of transcription from RNA polymerase II promoterGO:0459448.0RPS27A, TLR4, TLR2, TNF, IL1B

Molecular functions related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.5TLR2, TLR4

Products for genes affiliated with Endotoxin Hyporesponsiveness

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Sources for Endotoxin Hyporesponsiveness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet