MCID: END048
MIFTS: 37

Endotoxin Hyporesponsiveness malady

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Summaries for Endotoxin Hyporesponsiveness

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MalaCards based summary: Endotoxin Hyporesponsiveness is related to periodontal disease and leprosy. An important gene associated with Endotoxin Hyporesponsiveness is TLR4 (toll-like receptor 4), and among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include monocytes, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Endotoxin Hyporesponsiveness

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Endotoxin Hyporesponsiveness, Aliases & Descriptions:

Name: Endotoxin Hyporesponsiveness 46 62


Related Diseases for Endotoxin Hyporesponsiveness

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Diseases related to Endotoxin Hyporesponsiveness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1periodontal disease10.4TNF
2leprosy10.3TLR2
3colorectal cancer10.3RPS27A
4degenerative disc disease10.3IL1B
5skin disease10.2IL1B
6spondylarthropathy10.2TNF, TLR4
7invasive aspergillosis10.2TLR2, TLR4
8pouchitis10.2TLR4, TLR2
9melioidosis10.2TLR4, TLR2
10alcoholic hepatitis10.2RPS27A, TNF
11filariasis10.2TLR2, TLR4
12neisseria meningitidis infection10.2TLR4, TLR2
13malaria10.2TLR2, TNF
14ankylosing spondylitis10.2TNF, TLR4
15aspergillosis10.2TLR4, TLR2
16keratitis10.1TLR4, TLR2
17malt lymphoma10.1TLR4, TLR2
18atopy10.1TLR4, TLR2
19blau syndrome10.1IL1B, TNF
20aids dementia complex10.1TNF, IL1B
21familial mediterranean fever10.1TNF, IL1B
22arthritis10.0TNF, IL1B
23interstitial lung disease10.0TNF, IL1B
24cerebral malaria10.0IL1B, TNF
25toxic shock syndrome10.0IL1B, TNF
26allergic asthma10.0TLR4, TLR2
27adult respiratory distress syndrome10.0TNF, IL1B
28bacterial meningitis10.0IL1B, TLR2
29respiratory failure10.0IL1B, TNF
30otitis media10.0TLR2, IL1B
31arthropathy10.0TNF, IL1B
32insulin resistance10.0TLR4, TNF, RPS27A
33hepatitis c10.0TLR2, TLR4, TNF
34atopic dermatitis10.0TLR2, TLR4, TNF
35meningitis9.9IL1B, TLR2
36sarcoidosis9.9IL1B, TNF
37encephalitis9.9IL1B, TLR2
38chronic obstructive pulmonary disease9.9TLR2, TNF
39monocytic leukemia9.9TLR4, TNF, IL1B
40primary hyperoxaluria9.9IL1B, TNF
41endometriosis9.9RPS27A, IL1B
42hypersensitivity reaction type ii disease9.9IL1B, TNF, TLR4
43galactosemia9.9IL1B, TNF, TLR4
44congenital heart disease9.9TLR4, TNF, IL1B
45mastitis9.8IL1B, TLR4, TLR2
46periodontitis9.8TLR2, TLR4, IL1B
47inflammatory bowel disease9.8IL1B, TLR4, TLR2
48gastritis9.8TLR2, TLR4, IL1B
49psoriatic arthritis9.8TLR2, TNF, IL1B
50peritonitis9.8IL1B, TNF, TLR2

Graphical network of the top 20 diseases related to Endotoxin Hyporesponsiveness:



Diseases related to endotoxin hyporesponsiveness

Symptoms for Endotoxin Hyporesponsiveness

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Drugs & Therapeutics for Endotoxin Hyporesponsiveness

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Drug clinical trials:

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Search NIH Clinical Center for Endotoxin Hyporesponsiveness

Genetic Tests for Endotoxin Hyporesponsiveness

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Anatomical Context for Endotoxin Hyporesponsiveness

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MalaCards organs/tissues related to Endotoxin Hyporesponsiveness:

32
Monocytes

Animal Models for Endotoxin Hyporesponsiveness or affiliated genes

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MGI Mouse Phenotypes related to Endotoxin Hyporesponsiveness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8TNF, TLR4, TLR2
2MP:00020068.2IL1B, TNF, TLR4, TLR2
3MP:00053908.1TLR2, TLR4, TNF, IL1B
4MP:00053858.1TLR2, TLR4, TNF, IL1B
5MP:00053878.1IL1B, TNF, TLR4, TLR2
6MP:00053977.8TLR2, TLR4, TNF, IL1B

Publications for Endotoxin Hyporesponsiveness

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Articles related to Endotoxin Hyporesponsiveness:

idTitleAuthorsYear
1
N-Acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness. (15733769)
2005
2
Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. (12406900)
2003
3
Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery. (11323370)
2001
4
Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium. (11396812)
2001
5
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. (10835634)
2000

Variations for Endotoxin Hyporesponsiveness

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Expression for genes affiliated with Endotoxin Hyporesponsiveness

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Expression patterns in normal tissues for genes affiliated with Endotoxin Hyporesponsiveness

Search GEO for disease gene expression data for Endotoxin Hyporesponsiveness.

Pathways for genes affiliated with Endotoxin Hyporesponsiveness

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Pathways related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5RPS27A, TLR4
2
Show member pathways
9.4RPS27A, TNF
39.4TLR4, TLR2
4
Show member pathways
9.4TLR4, TLR2
5
Show member pathways
9.3TNF, TLR2
6
Show member pathways
9.2IL1B, TLR4
7
Show member pathways
9.1RPS27A, IL1B
89.1IL1B, TNF
9
Show member pathways
Serotonin Transporter Activity37
9.1TNF, IL1B
109.1IL1B, TNF
119.1IL1B, TNF
129.1IL1B, TNF
13
Show member pathways
9.1IL1B, TNF
149.1TNF, IL1B
159.1IL1B, TNF
169.1IL1B, TNF
179.1TNF, IL1B
18
Show member pathways
thioredoxin pathway37
9.1TNF, IL1B
199.1TNF, IL1B
209.0TLR2, IL1B
218.9TNF, TLR4, TLR2
228.9TLR2, TLR4, TNF
23
Show member pathways
8.9TLR2, TLR4, TNF
248.7TLR4, TNF, IL1B
25
Show member pathways
8.7IL1B, TNF, TLR4
268.7IL1B, TNF, TLR4
278.7TLR4, TNF, IL1B
28
Show member pathways
8.7TLR4, TNF, IL1B
29
Show member pathways
Immune response MIF in innate immunity response60
8.7TLR4, TNF, IL1B
308.7IL1B, TNF, TLR4
31
Show member pathways
8.6IL1B, TLR4, TLR2
32
Show member pathways
8.6IL1B, TLR4, TLR2
33
Show member pathways
8.1IL1B, TNF, TLR4, TLR2
348.1IL1B, TNF, TLR4, TLR2
358.1TLR2, TLR4, TNF, IL1B
36
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.1TLR2, TLR4, TNF, IL1B
37
Show member pathways
IL27-mediated signaling events37
8.1TLR2, TLR4, TNF, IL1B
388.1TLR2, TLR4, TNF, IL1B
398.1TLR2, TLR4, TNF, IL1B
408.1TLR2, TLR4, TNF, IL1B
41
Show member pathways
8.1TLR2, TLR4, TNF, IL1B
42
Show member pathways
8.1IL1B, TNF, TLR4, TLR2
43
Show member pathways
8.1TLR2, TLR4, TNF, IL1B
44
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.1TLR2, TLR4, TNF, IL1B
45
Show member pathways
8.1IL1B, TNF, TLR4, TLR2
468.1IL1B, TNF, TLR4, TLR2
47
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.1TLR2, TLR4, TNF, IL1B
488.1IL1B, TNF, TLR4, TLR2

Compounds for genes affiliated with Endotoxin Hyporesponsiveness

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Compounds related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1arabinogalactan449.7TLR4, TLR2
2diaminopimelic acid449.7TLR4, TLR2
3loxoribine44 2810.6TLR4, TLR2
4poly(i:c)619.6TLR2, TLR4
5pam3csk4619.6TLR4, TLR2
6pam2csk4619.6TLR2, TLR4
7d-galactosamine449.6TNF, TLR4
8glucuronoxylomannan449.5TLR4, TLR2
9chloroquine44 2 50 28 1113.3RPS27A, TNF, TLR4
10zymosan449.3TNF, TLR4, TLR2
11imiquimod44 61 28 1112.3TLR2, TLR4, TNF
12palmitate449.1TLR4, RPS27A, TLR2
13diphenyleneiodonium449.0IL1B, TNF, TLR4
14infliximab44 50 1111.0TLR4, TNF, IL1B
15c2ceramide449.0IL1B, TLR4, TNF
16muramyl dipeptide44 2810.0TLR4, TLR2, IL1B
17tpck449.0RPS27A, TNF, IL1B
18hbd2449.0IL1B, TLR2, TLR4
19pdtc449.0IL1B, TNF, TLR4
20flagellin44 2810.0IL1B, TLR4, TLR2
21leukotriene b444 61 2410.8IL1B, TLR2, TNF
22sp 60012544 619.8IL1B, TNF, TLR2
23tacrolimus44 50 1110.8TLR4, RPS27A, TNF, TLR2
24troglitazone44 28 61 1111.7IL1B, RPS27A, TNF
25cyclosporin a44 28 6110.7TLR4, TLR2, RPS27A, TNF
26h2o2448.6TNF, RPS27A, TLR2, TLR4
27mg 13244 619.6RPS27A, IL1B, TNF
28herbimycin a44 619.6RPS27A, IL1B, TNF
29simvastatin44 50 61 28 24 1113.6TNF, TLR4, TLR2
30tgf beta1448.6TLR4, IL1B, TNF
31n acetylcysteine448.5RPS27A, TNF, IL1B, TLR4
32polymyxin b448.5TLR4, TNF, TLR2, IL1B
33lipoteichoic acid448.5IL1B, TNF, TLR4, TLR2
34polyinosinic-polycytidylic acid448.5IL1B, TLR2, TLR4, TNF
35poly(i-c)448.5TNF, IL1B, TLR4, TLR2
36il 10448.5TLR2, IL1B, TLR4, TNF
37peptidoglycan44 289.5TLR4, TNF, IL1B, TLR2
38ccl344 289.5TLR2, TLR4, TNF, IL1B
39endotoxin448.5TNF, TLR4, TLR2, IL1B
40calcitriol44 61 24 1111.5TLR2, TLR4, IL1B, TNF
41rantes448.4TLR2, TLR4, IL1B, TNF
42sb 20358044 619.4IL1B, TLR2, TNF, TLR4
43histamine44 28 2410.4TLR4, IL1B, TLR2, TNF
44superoxide44 249.4TLR2, TLR4, TNF, IL1B
45actinomycin d448.0IL1B, RPS27A, TLR4, TNF, TLR2
46pge2448.0TLR2, TLR4, TNF, IL1B, RPS27A
47cycloheximide448.0TNF, RPS27A, TLR4, TLR2, IL1B
48dexamethasone44 50 28 1110.9TLR2, RPS27A, IL1B, TNF, TLR4
49vegf447.9TLR2, TNF, IL1B, TLR4, RPS27A
50retinoic acid44 248.9TLR4, TLR2, IL1B, RPS27A, TNF

GO Terms for genes affiliated with Endotoxin Hyporesponsiveness

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Cellular components related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9TNF, TLR4, TLR2

Biological processes related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:0454169.9TLR4, TNF
2positive regulation of macrophage cytokine productionGO:0609079.8TLR4, TLR2
3negative regulation of interleukin-6 productionGO:0327159.8TNF, TLR4
4cellular response to lipoteichoic acidGO:0712239.8TLR4, TLR2
5negative regulation of interleukin-17 productionGO:0327009.7TLR2, TLR4
6positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR4, TLR2
7positive regulation of interleukin-18 productionGO:0327419.7TLR2, TNF
8positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR2, TLR4
9I-kappaB phosphorylationGO:0072529.7TLR2, TLR4
10positive regulation of interleukin-10 productionGO:0327339.7TLR4, TLR2
11positive regulation of interferon-beta productionGO:0327289.7TLR2, TLR4
12negative regulation of growth of symbiont in hostGO:0441309.6TNF, TLR2
13positive regulation of interleukin-12 productionGO:0327359.6TLR4, TLR2
14positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5TNF, IL1B
15sequestering of triglycerideGO:0307309.5TNF, IL1B
16positive regulation of cytokine secretionGO:0507159.5TNF, TLR2
17positive regulation of fever generationGO:0316229.5IL1B, TNF
18positive regulation of heterotypic cell-cell adhesionGO:0341169.5IL1B, TNF
19positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL1B
20regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.5IL1B, TNF
21positive regulation of membrane protein ectodomain proteolysisGO:0510449.4IL1B, TNF
22negative regulation of lipid catabolic processGO:0509959.4TNF, IL1B
23positive regulation of tumor necrosis factor productionGO:0327609.4TLR4, TLR2
24positive regulation of chemokine productionGO:0327229.3TNF, TLR4, TLR2
25positive regulation of mitosisGO:0458409.3TNF, IL1B
26toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.3TLR2, TLR4, RPS27A
27toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.3TLR2, TLR4, RPS27A
28toll-like receptor 2 signaling pathwayGO:0341349.3RPS27A, TLR4, TLR2
29MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3RPS27A, TLR4, TLR2
30toll-like receptor 4 signaling pathwayGO:0341429.3TLR2, TLR4, RPS27A
31toll-like receptor signaling pathwayGO:0022249.3TLR2, TLR4, RPS27A
32protein kinase B signalingGO:0434919.2IL1B, TNF
33defense response to Gram-positive bacteriumGO:0508309.2TNF, TLR2
34negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.2IL1B, TNF
35positive regulation of interferon-gamma productionGO:0327299.1TLR4, TNF, IL1B
36positive regulation of JNK cascadeGO:0463309.1IL1B, TNF, TLR4
37positive regulation of interleukin-8 productionGO:0327579.0TLR2, TLR4, IL1B
38cellular response to organic cyclic compoundGO:0714078.8IL1B, TNF
39inflammatory responseGO:0069548.7IL1B, TNF, TLR2
40immune responseGO:0069558.7IL1B, TLR4, TLR2
41activation of MAPK activityGO:0001878.6TLR4, TNF, IL1B, RPS27A
42positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.6TLR4, TNF, IL1B, RPS27A
43negative regulation of cell proliferationGO:0082858.5TLR2, TNF, IL1B
44positive regulation of NF-kappaB import into nucleusGO:0423468.5IL1B, TNF, TLR4, TLR2
45lipopolysaccharide-mediated signaling pathwayGO:0316638.5IL1B, TNF, TLR4, TLR2
46positive regulation of nitric oxide biosynthetic processGO:0454298.5TLR2, TLR4, TNF, IL1B
47positive regulation of interleukin-6 productionGO:0327558.5IL1B, TNF, TLR4, TLR2
48apoptotic processGO:0069158.4TLR2, TNF, IL1B, RPS27A
49positive regulation of NF-kappaB transcription factor activityGO:0510928.0TLR2, TLR4, TNF, IL1B, RPS27A
50positive regulation of transcription from RNA polymerase II promoterGO:0459448.0RPS27A, IL1B, TNF, TLR4, TLR2

Molecular functions related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR4, TLR2
2lipopolysaccharide receptor activityGO:0018759.1TLR4, TLR2

Products for genes affiliated with Endotoxin Hyporesponsiveness

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Sources for Endotoxin Hyporesponsiveness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet