MCID: END048
MIFTS: 31

Endotoxin Hyporesponsiveness malady

Summaries for Endotoxin Hyporesponsiveness

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32MalaCards
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MalaCards: Endotoxin Hyporesponsiveness is related to acute pancreatitis and thrombocytopenia. An important gene associated with Endotoxin Hyporesponsiveness is TLR4 (toll-like receptor 4), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Phagocytosis of Microbes. The compounds cycloheximide and cyclosporin a have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and tumorigenesis.

Aliases & Classifications for Endotoxin Hyporesponsiveness

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46OMIM, 60UMLS
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Aliases & Descriptions:

endotoxin hyporesponsiveness 46 60


Related Diseases for Endotoxin Hyporesponsiveness

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Endotoxin Hyporesponsiveness:



Diseases related to endotoxin hyporesponsiveness

Clinical Features for Endotoxin Hyporesponsiveness

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Drugs & Therapeutics for Endotoxin Hyporesponsiveness

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Endotoxin Hyporesponsiveness

Drug clinical trials:

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Search NIH Clinical Center for Endotoxin Hyporesponsiveness

Search CenterWatch for Endotoxin Hyporesponsiveness

Genetic Tests for Endotoxin Hyporesponsiveness

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Anatomical Context for Endotoxin Hyporesponsiveness

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Animal Models for Endotoxin Hyporesponsiveness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Endotoxin Hyporesponsiveness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7IL1B
2MP:00020068.8IL1B, TNF

Publications for Endotoxin Hyporesponsiveness

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Genetic Variations for Endotoxin Hyporesponsiveness

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Expression for genes affiliated with Endotoxin Hyporesponsiveness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Endotoxin Hyporesponsiveness

Search GEO for disease gene expression data for Endotoxin Hyporesponsiveness.

Pathways for genes affiliated with Endotoxin Hyporesponsiveness

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Sources:
12EMD Millipore, 51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 59Tocris Bioscience, 4Cell Signaling Technology
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Pathways related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, TLR4
29.5TLR2, TLR4
3
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9.5TLR2, TLR4
49.5TLR4, TNF
5
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9.4TLR4, RPS27A
6
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9.3TNF, RPS27A
79.1IL1B, TLR2
89.1IL1B, TNF
99.1TNF, IL1B
109.1IL1B, TNF
119.1IL1B, TNF
129.1IL1B, TNF
139.1TNF, IL1B
14
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9.0IL1B, RPS27A
159.0TNF, TLR2, TLR4
16
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9.0TLR4, TLR2, TNF
17
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8.9RPS27A, TLR4, TLR2
18
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8.7IL1B, TLR2, TLR4
19
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8.7TLR4, TNF, IL1B
208.7TLR4, TNF, IL1B
218.7IL1B, TNF, TLR4
228.7IL1B, TNF, TLR4
23
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8.7IL1B, TNF, TLR4
248.7TLR4, TNF, IL1B
25
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8.5IL1B, TNF, RPS27A
268.2TLR4, TLR2, TNF, IL1B
278.2TLR4, TLR2, TNF, IL1B
28
Immune response Bacterial infections in normal airways
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8.2TLR4, TLR2, TNF, IL1B
29
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8.2TLR4, TLR2, TNF, IL1B
308.2TLR4, TLR2, TNF, IL1B
318.2TLR4, TLR2, TNF, IL1B
32
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8.2TLR4, TLR2, TNF, IL1B
33
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8.2TLR4, TLR2, TNF, IL1B
34
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8.2TLR4, TLR2, TNF, IL1B
358.2TLR4, TLR2, TNF, IL1B
36
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8.2TLR4, TLR2, TNF, IL1B
37
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8.2TLR4, TLR2, TNF, IL1B
38
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8.2IL1B, TNF, TLR2, TLR4
39
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8.2IL1B, TNF, TLR2, TLR4
408.2IL1B, TNF, TLR2, TLR4
418.2IL1B, TNF, TLR2, TLR4
42
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8.1IL1B, TLR2, TLR4, RPS27A

Compounds for genes affiliated with Endotoxin Hyporesponsiveness

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4TLR2
2cyclosporin a44 28 5912.2RPS27A
3h2o24410.1RPS27A
4diphenyleneiodonium4410.0IL1B
5dexamethasone44 49 28 1112.9TLR2, TLR4
6arabinogalactan449.9TLR4, TLR2
7diaminopimelic acid449.8TLR4, TLR2
8pam2csk4599.8TLR4, TLR2
9loxoribine44 2810.8TLR2, TLR4
10poly(i:c)599.8TLR2, TLR4
11pam3csk4599.8TLR2, TLR4
12tacrolimus44 49 1111.8RPS27A, TLR2
13glucuronoxylomannan449.7TLR2, TLR4
14d-galactosamine449.7TNF, TLR4
15resiquimod44 5910.6TLR4, TLR2
16superoxide44 2410.5IL1B, TNF
17zymosan449.4TNF, TLR4, TLR2
18imiquimod44 28 59 1112.4TNF, TLR2, TLR4
19chloroquine44 2 49 28 1113.2TNF, TLR4, RPS27A
20n,n-dimethylsphingosine44 5910.1TNF, IL1B
21muramyl dipeptide44 2810.1IL1B, TLR4, TLR2
22hbd2449.1IL1B, TLR4, TLR2
23flagellin44 2810.1TLR4, TLR2, IL1B
24palmitate449.1TLR4, RPS27A, TLR2
25infliximab44 49 1111.0TLR4, TNF, IL1B
26c2ceramide449.0TNF, TLR4, IL1B
27pdtc449.0TLR4, IL1B, TNF
28tpck448.9RPS27A, TNF, IL1B
29leukotriene b444 59 2410.9IL1B, TNF, TLR2
30simvastatin44 49 59 28 11 2413.9TNF, TLR2, TLR4
31sp 60012544 599.9TLR2, TNF, IL1B
32tgf beta1448.7IL1B, TNF, TLR4
33troglitazone44 28 59 1111.7TNF, IL1B, RPS27A
34polymyxin b448.6IL1B, TNF, TLR2, TLR4
35lipoteichoic acid448.6TLR4, TLR2, TNF, IL1B
36polyinosinic-polycytidylic acid448.6TLR2, IL1B, TNF, TLR4
37poly(i-c)448.6IL1B, TNF, TLR2, TLR4
38il 10448.6IL1B, TNF, TLR4, TLR2
39peptidoglycan44 289.6IL1B, TNF, TLR4, TLR2
40ccl344 289.6TLR2, IL1B, TNF, TLR4
41mg 13244 599.6TNF, RPS27A, IL1B
42calcitriol44 59 11 2411.6IL1B, TLR4, TLR2, TNF
43rantes448.5TLR4, IL1B, TNF, TLR2
44sb 20358044 599.5TLR2, TLR4, IL1B, TNF
45histamine44 28 2410.5TNF, IL1B, TLR2, TLR4
46n acetylcysteine448.4TNF, IL1B, TLR4, RPS27A
47herbimycin a44 599.2TNF, IL1B, RPS27A
48actinomycin d448.0IL1B, TNF, TLR2, RPS27A, TLR4
49vegf447.9IL1B, TLR2, RPS27A, TNF, TLR4
50retinoic acid44 248.9IL1B, TNF, RPS27A, TLR4, TLR2

GO Terms for genes affiliated with Endotoxin Hyporesponsiveness

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16Gene Ontology
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Cellular components related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0TNF, TLR2, TLR4

Biological processes related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage cytokine productionGO:0609079.9TLR2, TLR4
2cellular response to lipoteichoic acidGO:0712239.9TLR2, TLR4
3positive regulation of interleukin-8 biosynthetic processGO:0454169.9TLR4, TNF
4negative regulation of interleukin-17 productionGO:0327009.9TLR4, TLR2
5positive regulation of tumor necrosis factor biosynthetic processGO:0425359.8TLR2, TLR4
6positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.8TLR4, TLR2
7I-kappaB phosphorylationGO:0072529.8TLR4, TLR2
8negative regulation of interleukin-6 productionGO:0327159.8TLR4, TNF
9positive regulation of interferon-beta productionGO:0327289.8TLR2, TLR4
10positive regulation of interleukin-12 productionGO:0327359.8TLR2, TLR4
11negative regulation of growth of symbiont in hostGO:0441309.7TNF, TLR2
12positive regulation of cytokine secretionGO:0507159.7TLR2, TNF
13positive regulation of tumor necrosis factor productionGO:0327609.6TLR2, TLR4
14sequestering of triglycerideGO:0307309.6IL1B, TNF
15positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, TNF
16positive regulation of heterotypic cell-cell adhesionGO:0341169.5TNF, IL1B
17positive regulation of fever generationGO:0316229.5IL1B, TNF
18positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL1B
19regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.5IL1B, TNF
20positive regulation of membrane protein ectodomain proteolysisGO:0510449.5IL1B, TNF
21negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
22defense response to Gram-positive bacteriumGO:0508309.4TLR2, TNF
23positive regulation of chemokine productionGO:0327229.4TNF, TLR2, TLR4
24negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, TNF
25positive regulation of mitosisGO:0458409.4IL1B, TNF
26cellular response to organic cyclic compoundGO:0714079.3IL1B, TNF
27JNK cascadeGO:0072549.3TNF, RPS27A
28I-kappaB kinase/NF-kappaB cascadeGO:0072499.3TLR4, RPS27A
29toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.3RPS27A, TLR4, TLR2
30toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.3RPS27A, TLR4, TLR2
31toll-like receptor 2 signaling pathwayGO:0341349.3TLR2, TLR4, RPS27A
32protein kinase B signaling cascadeGO:0434919.3IL1B, TNF
33MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3RPS27A, TLR4, TLR2
34toll-like receptor 4 signaling pathwayGO:0341429.3RPS27A, TLR4, TLR2
35toll-like receptor signaling pathwayGO:0022249.3RPS27A, TLR4, TLR2
36positive regulation of inflammatory responseGO:0507299.2TLR2, TLR4
37positive regulation of interleukin-8 productionGO:0327579.1TLR4, TLR2, IL1B
38positive regulation of interferon-gamma productionGO:0327299.1IL1B, TNF, TLR4
39positive regulation of JNK cascadeGO:0463309.1TLR4, TNF, IL1B
40inflammatory responseGO:0069548.8TLR2, TNF, IL1B
41immune responseGO:0069558.7IL1B, TLR2, TLR4
42positive regulation of NF-kappaB import into nucleusGO:0423468.6TLR4, TLR2, TNF, IL1B
43lipopolysaccharide-mediated signaling pathwayGO:0316638.6IL1B, TNF, TLR2, TLR4
44positive regulation of nitric oxide biosynthetic processGO:0454298.6TLR4, TLR2, TNF, IL1B
45positive regulation of interleukin-6 productionGO:0327558.6IL1B, TNF, TLR2, TLR4
46activation of MAPK activityGO:0001878.5RPS27A, TLR4, TNF, IL1B
47positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.5RPS27A, TLR4, TNF, IL1B
48apoptotic processGO:0069158.3RPS27A, TLR2, TNF, IL1B
49positive regulation of NF-kappaB transcription factor activityGO:0510928.0IL1B, TNF, TLR2, TLR4, RPS27A
50positive regulation of transcription from RNA polymerase II promoterGO:0459448.0RPS27A, TLR4, TLR2, TNF, IL1B

Molecular functions related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.5TLR2, TLR4

Products for genes affiliated with Endotoxin Hyporesponsiveness

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Sources for Endotoxin Hyporesponsiveness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet