MCID: END048
MIFTS: 37

Endotoxin Hyporesponsiveness malady

Summaries for Endotoxin Hyporesponsiveness

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MalaCards based summary: Endotoxin Hyporesponsiveness is related to periodontal disease and leprosy. An important gene associated with Endotoxin Hyporesponsiveness is TLR4 (toll-like receptor 4), and among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include monocytes, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Endotoxin Hyporesponsiveness

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Endotoxin Hyporesponsiveness, Aliases & Descriptions:

Name: Endotoxin Hyporesponsiveness 46 61


Related Diseases for Endotoxin Hyporesponsiveness

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Diseases related to Endotoxin Hyporesponsiveness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1periodontal disease10.4TNF
2leprosy10.3TLR2
3colorectal cancer10.3RPS27A
4degenerative disc disease10.3IL1B
5skin disease10.2IL1B
6spondylarthropathy10.2TLR4, TNF
7invasive aspergillosis10.2TLR4, TLR2
8pouchitis10.2TLR2, TLR4
9melioidosis10.2TLR2, TLR4
10alcoholic hepatitis10.2TNF, RPS27A
11filariasis10.2TLR4, TLR2
12neisseria meningitidis infection10.2TLR2, TLR4
13malaria10.2TNF, TLR2
14ankylosing spondylitis10.2TLR4, TNF
15aspergillosis10.2TLR2, TLR4
16keratitis10.1TLR2, TLR4
17malt lymphoma10.1TLR2, TLR4
18atopy10.1TLR4, TLR2
19blau syndrome10.1TNF, IL1B
20aids dementia complex10.1IL1B, TNF
21familial mediterranean fever10.1IL1B, TNF
22arthritis10.0IL1B, TNF
23interstitial lung disease10.0IL1B, TNF
24cerebral malaria10.0IL1B, TNF
25toxic shock syndrome10.0TNF, IL1B
26allergic asthma10.0TLR2, TLR4
27adult respiratory distress syndrome10.0TNF, IL1B
28bacterial meningitis10.0IL1B, TLR2
29respiratory failure10.0TNF, IL1B
30otitis media10.0IL1B, TLR2
31arthropathy10.0TNF, IL1B
32insulin resistance10.0TLR4, RPS27A, TNF
33hepatitis c10.0TLR2, TLR4, TNF
34atopic dermatitis10.0TLR4, TNF, TLR2
35meningitis9.9TLR2, IL1B
36sarcoidosis9.9TNF, IL1B
37encephalitis9.9IL1B, TLR2
38chronic obstructive pulmonary disease9.9TNF, TLR2
39monocytic leukemia9.9TLR4, IL1B, TNF
40primary hyperoxaluria9.9IL1B, TNF
41endometriosis9.9RPS27A, IL1B
42hypersensitivity reaction type ii disease9.9TLR4, IL1B, TNF
43galactosemia9.9TLR4, TNF, IL1B
44congenital heart disease9.9IL1B, TNF, TLR4
45mastitis9.9TLR2, TLR4, IL1B
46periodontitis9.8IL1B, TLR4, TLR2
47inflammatory bowel disease9.8IL1B, TLR2, TLR4
48gastritis9.8IL1B, TLR4, TLR2
49psoriatic arthritis9.8TLR2, TNF, IL1B
50peritonitis9.8TNF, TLR2, IL1B

Graphical network of the top 20 diseases related to Endotoxin Hyporesponsiveness:



Diseases related to endotoxin hyporesponsiveness

Symptoms for Endotoxin Hyporesponsiveness

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Drugs & Therapeutics for Endotoxin Hyporesponsiveness

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Drug clinical trials:

Search ClinicalTrials for Endotoxin Hyporesponsiveness

Search NIH Clinical Center for Endotoxin Hyporesponsiveness

Genetic Tests for Endotoxin Hyporesponsiveness

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Anatomical Context for Endotoxin Hyporesponsiveness

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MalaCards organs/tissues related to Endotoxin Hyporesponsiveness:

32
Monocytes

Animal Models for Endotoxin Hyporesponsiveness or affiliated genes

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MGI Mouse Phenotypes related to Endotoxin Hyporesponsiveness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8TLR2, TLR4, TNF
2MP:00020068.2TLR2, TLR4, TNF, IL1B
3MP:00053908.1IL1B, TNF, TLR4, TLR2
4MP:00053858.1TNF, TLR4, TLR2, IL1B
5MP:00053878.1TLR4, TNF, IL1B, TLR2
6MP:00053977.8IL1B, TNF, TLR4, TLR2

Publications for Endotoxin Hyporesponsiveness

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Articles related to Endotoxin Hyporesponsiveness:

idTitleAuthorsYear
1
N-Acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness. (15733769)
2005
2
Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. (12406900)
2003
3
Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery. (11323370)
2001
4
Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium. (11396812)
2001
5
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. (10835634)
2000

Variations for Endotoxin Hyporesponsiveness

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Expression for genes affiliated with Endotoxin Hyporesponsiveness

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Expression patterns in normal tissues for genes affiliated with Endotoxin Hyporesponsiveness

Search GEO for disease gene expression data for Endotoxin Hyporesponsiveness.

Pathways for genes affiliated with Endotoxin Hyporesponsiveness

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Pathways related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR4, RPS27A
2
Show member pathways
9.4RPS27A, TNF
39.4TLR2, TLR4
4
Show member pathways
9.4TLR2, TLR4
5
Show member pathways
9.3TNF, TLR2
6
Show member pathways
9.2TLR4, IL1B
7
Show member pathways
9.1RPS27A, IL1B
89.1IL1B, TNF
99.1TNF, IL1B
109.1IL1B, TNF
119.1IL1B, TNF
129.1TNF, IL1B
13
Show member pathways
9.1TNF, IL1B
149.1IL1B, TNF
159.1TNF, IL1B
169.1IL1B, TNF
17
Show member pathways
thioredoxin pathway37
9.1TNF, IL1B
189.1IL1B, TNF
19
Show member pathways
Serotonin Transporter Activity37
9.1IL1B, TNF
209.0TLR2, IL1B
21
Show member pathways
8.9TNF, TLR2, TLR4
228.9TLR4, TLR2, TNF
238.9TLR2, TNF, TLR4
248.7TLR4, TNF, IL1B
25
Show member pathways
8.7TLR4, TNF, IL1B
26
Show member pathways
Immune response MIF in innate immunity response59
8.7TLR4, IL1B, TNF
278.7IL1B, TNF, TLR4
28
Show member pathways
8.7TNF, TLR4, IL1B
298.7TLR4, TNF, IL1B
308.7TNF, IL1B, TLR4
31
Show member pathways
8.6IL1B, TLR4, TLR2
32
Show member pathways
8.6TLR2, TLR4, IL1B
33
Show member pathways
8.1IL1B, TLR4, TLR2, TNF
348.1TNF, IL1B, TLR2, TLR4
358.1TLR4, TNF, TLR2, IL1B
36
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.1TNF, TLR4, IL1B, TLR2
37
Show member pathways
IL27-mediated signaling events37
8.1TLR4, TNF, IL1B, TLR2
388.1TLR2, TNF, TLR4, IL1B
398.1TLR2, TLR4, IL1B, TNF
408.1IL1B, TNF, TLR4, TLR2
41
Show member pathways
8.1TLR2, TLR4, TNF, IL1B
42
Show member pathways
8.1TLR2, TLR4, TNF, IL1B
43
Show member pathways
8.1TLR2, TLR4, IL1B, TNF
44
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.1IL1B, TLR4, TLR2, TNF
45
Show member pathways
8.1TLR4, TLR2, TNF, IL1B
468.1TLR4, TLR2, IL1B, TNF
47
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.1TLR4, TNF, TLR2, IL1B
488.1TLR2, TNF, IL1B, TLR4

Compounds for genes affiliated with Endotoxin Hyporesponsiveness

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Compounds related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1arabinogalactan449.7TLR4, TLR2
2diaminopimelic acid449.7TLR4, TLR2
3loxoribine44 2910.6TLR4, TLR2
4poly(i:c)609.6TLR2, TLR4
5pam3csk4609.6TLR4, TLR2
6pam2csk4609.6TLR2, TLR4
7d-galactosamine449.6TNF, TLR4
8glucuronoxylomannan449.5TLR4, TLR2
9chloroquine44 3 50 29 1213.3RPS27A, TNF, TLR4
10zymosan449.3TNF, TLR4, TLR2
11imiquimod44 60 29 1212.3TLR2, TLR4, TNF
12palmitate449.1TLR4, RPS27A, TLR2
13diphenyleneiodonium449.0IL1B, TNF, TLR4
14infliximab44 50 1211.0TLR4, TNF, IL1B
15c2ceramide449.0IL1B, TLR4, TNF
16muramyl dipeptide44 2910.0TLR4, TLR2, IL1B
17tpck449.0RPS27A, TNF, IL1B
18hbd2449.0IL1B, TLR2, TLR4
19pdtc449.0IL1B, TNF, TLR4
20flagellin44 2910.0IL1B, TLR4, TLR2
21leukotriene b444 60 2510.8IL1B, TLR2, TNF
22sp 60012544 609.8IL1B, TNF, TLR2
23tacrolimus44 50 1210.8TLR4, RPS27A, TNF, TLR2
24troglitazone44 29 60 1211.7IL1B, RPS27A, TNF
25cyclosporin a44 29 6010.7TLR4, TLR2, RPS27A, TNF
26h2o2448.6TNF, RPS27A, TLR2, TLR4
27mg 13244 609.6RPS27A, IL1B, TNF
28herbimycin a44 609.6RPS27A, IL1B, TNF
29simvastatin44 50 60 29 25 1213.6TNF, TLR4, TLR2
30tgf beta1448.6TLR4, IL1B, TNF
31n acetylcysteine448.5RPS27A, TNF, IL1B, TLR4
32polymyxin b448.5TLR4, TNF, TLR2, IL1B
33lipoteichoic acid448.5IL1B, TNF, TLR4, TLR2
34polyinosinic-polycytidylic acid448.5IL1B, TLR2, TLR4, TNF
35poly(i-c)448.5TNF, IL1B, TLR4, TLR2
36il 10448.5TLR2, IL1B, TLR4, TNF
37peptidoglycan44 299.5TLR4, TNF, IL1B, TLR2
38ccl344 299.5TLR2, TLR4, TNF, IL1B
39endotoxin448.5TNF, TLR4, TLR2, IL1B
40calcitriol44 60 25 1211.5TLR2, TLR4, IL1B, TNF
41rantes448.4TLR2, TLR4, IL1B, TNF
42sb 20358044 609.4IL1B, TLR2, TNF, TLR4
43histamine44 29 2510.4TLR4, IL1B, TLR2, TNF
44superoxide44 259.4TLR2, TLR4, TNF, IL1B
45actinomycin d448.0IL1B, RPS27A, TLR4, TNF, TLR2
46pge2448.0TLR2, TLR4, TNF, IL1B, RPS27A
47cycloheximide448.0TNF, RPS27A, TLR4, TLR2, IL1B
48dexamethasone44 50 29 1210.9TLR2, RPS27A, IL1B, TNF, TLR4
49vegf447.9TLR2, TNF, IL1B, TLR4, RPS27A
50retinoic acid44 258.9TLR4, TLR2, IL1B, RPS27A, TNF

GO Terms for genes affiliated with Endotoxin Hyporesponsiveness

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Cellular components related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9TNF, TLR4, TLR2

Biological processes related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:0454169.9TNF, TLR4
2positive regulation of macrophage cytokine productionGO:0609079.8TLR4, TLR2
3negative regulation of interleukin-6 productionGO:0327159.8TNF, TLR4
4cellular response to lipoteichoic acidGO:0712239.8TLR2, TLR4
5negative regulation of interleukin-17 productionGO:0327009.7TLR2, TLR4
6positive regulation of interleukin-18 productionGO:0327419.7TNF, TLR2
7positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR4, TLR2
8I-kappaB phosphorylationGO:0072529.7TLR2, TLR4
9positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR4, TLR2
10positive regulation of interleukin-10 productionGO:0327339.7TLR2, TLR4
11positive regulation of interferon-beta productionGO:0327289.7TLR2, TLR4
12negative regulation of growth of symbiont in hostGO:0441309.6TNF, TLR2
13positive regulation of interleukin-12 productionGO:0327359.6TLR2, TLR4
14positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, TNF
15sequestering of triglycerideGO:0307309.5TNF, IL1B
16positive regulation of cytokine secretionGO:0507159.5TNF, TLR2
17positive regulation of heterotypic cell-cell adhesionGO:0341169.5TNF, IL1B
18positive regulation of fever generationGO:0316229.5IL1B, TNF
19positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL1B
20regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.5TNF, IL1B
21positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IL1B
22negative regulation of lipid catabolic processGO:0509959.4TNF, IL1B
23positive regulation of tumor necrosis factor productionGO:0327609.4TLR4, TLR2
24positive regulation of chemokine productionGO:0327229.3TNF, TLR4, TLR2
25positive regulation of mitosisGO:0458409.3TNF, IL1B
26toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.3TLR4, RPS27A, TLR2
27toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.3TLR2, TLR4, RPS27A
28toll-like receptor 2 signaling pathwayGO:0341349.3TLR4, TLR2, RPS27A
29MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3RPS27A, TLR4, TLR2
30toll-like receptor 4 signaling pathwayGO:0341429.3TLR4, RPS27A, TLR2
31toll-like receptor signaling pathwayGO:0022249.3TLR2, RPS27A, TLR4
32protein kinase B signalingGO:0434919.2TNF, IL1B
33negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.2TNF, IL1B
34positive regulation of interferon-gamma productionGO:0327299.1IL1B, TNF, TLR4
35positive regulation of JNK cascadeGO:0463309.1IL1B, TNF, TLR4
36cellular response to organic cyclic compoundGO:0714079.0TNF, IL1B
37defense response to Gram-positive bacteriumGO:0508309.0TLR2, TNF
38positive regulation of interleukin-8 productionGO:0327579.0TLR2, IL1B, TLR4
39inflammatory responseGO:0069548.7TNF, IL1B, TLR2
40immune responseGO:0069558.7IL1B, TLR2, TLR4
41activation of MAPK activityGO:0001878.6RPS27A, TLR4, TNF, IL1B
42positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.6IL1B, RPS27A, TLR4, TNF
43negative regulation of cell proliferationGO:0082858.5TLR2, TNF, IL1B
44positive regulation of NF-kappaB import into nucleusGO:0423468.5TLR2, IL1B, TNF, TLR4
45lipopolysaccharide-mediated signaling pathwayGO:0316638.5TNF, TLR4, IL1B, TLR2
46positive regulation of nitric oxide biosynthetic processGO:0454298.5TLR2, TLR4, TNF, IL1B
47positive regulation of interleukin-6 productionGO:0327558.5IL1B, TLR2, TLR4, TNF
48apoptotic processGO:0069158.4TNF, TLR2, RPS27A, IL1B
49positive regulation of NF-kappaB transcription factor activityGO:0510928.0RPS27A, IL1B, TNF, TLR4, TLR2
50positive regulation of transcription from RNA polymerase II promoterGO:0459448.0RPS27A, IL1B, TNF, TLR4, TLR2

Molecular functions related to Endotoxin Hyporesponsiveness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR4, TLR2
2lipopolysaccharide receptor activityGO:0018759.1TLR4, TLR2

Products for genes affiliated with Endotoxin Hyporesponsiveness

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Sources for Endotoxin Hyporesponsiveness

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet